Journal of Materials Chemistry B最新文献

{"title":"Overcoming cancer immunotherapy barriers via nanomaterial-mediated pyroptosis","authors":"Jianlei Xie, Baoxin Peng, Yu Xiao, Xiasang Chen, Xinyin Zhang, Diqi Chen, Lijuan Song, Meiqian Xu, Wenjing Liao and Xiaowen Zhang","doi":"10.1039/D5TB01024A","DOIUrl":"10.1039/D5TB01024A","url":null,"abstract":"<p >While cancer immunotherapy has achieved groundbreaking clinical success, its efficacy is frequently compromised by insufficient T-cell activation, the immunosuppressive tumor microenvironment (TME), and off-target toxicity. Pyroptosis, a highly immunogenic form of programmed cell death characterized by gasdermin-mediated pore formation, massive cytokine release (<em>e.g.</em>, IL-1β and IL-18), and robust dendritic cell activation, offers a compelling strategy to overcome these limitations. This review critically examines how nanotechnology-enabled pyroptosis induction can potentiate immunotherapy by (1) classifying pyroptosis-inducing nanomaterials into five combinatorial therapeutic platforms – immune checkpoint inhibitors, vaccine adjuvants, oncolytic virus-coupled systems, innate immune sensitizers, and multi-modal hybrids; (2) elucidating their mechanisms in reshaping the TME <em>via</em> pyroptosis-induced immunogenicity and bystander immune cell activation; and (3) highlighting unresolved challenges, including tumor-intrinsic pyroptosis resistance, nanoparticle biodistribution barriers, and cytokine storm risks. By integrating fundamental insights with translational perspectives, this work provides a strategic framework for developing pyroptosis-nanotechnology synergies to achieve precision immune modulation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11485-11507"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave sintered multifunctional Fe–30Mn–xCu biomedical alloys: microstructure, mechanical properties, MRI compatibility, biodegradation, antibacterial activity, cytocompatibility, and osteogenic differentiation","authors":"Xin Huang, Xin Li, Yingchao Zhao, Dengfeng Yin and Ming-Chun Zhao","doi":"10.1039/D5TB00640F","DOIUrl":"10.1039/D5TB00640F","url":null,"abstract":"<p >Fe–Mn–Cu alloys show promise for temporary bone implants due to Fe's biodegradability, Mn's enhanced antiferromagnetism, and Cu's antibacterial properties. Microwave sintering is a prevalent metal processing technique, offering unique volumetric heating that can enhance physicomechanical properties. However, its application to Fe–Mn–Cu alloys remains underexplored. This work systematically investigates physicomechanical and biological properties of microwave sintered Fe–30Mn–<em>x</em>Cu alloys (<em>x</em> = 0, 1, 4, 8). Cu content played a crucial role in performance. Incorporation of Cu stabilizes the γ-austenite phase, homogenizes the microstructure with increasing Cu content, and induces precipitation of excess Cu. Yield strength and Vickers hardness initially decrease and then increase with Cu content, reaching minima at 3 wt% Cu. Notably, the alloys exhibit excellent ductility, with elastic moduli approaching that of human bone. Biodegradation rates exceed those of compositionally equivalent alloys prepared <em>via</em> conventional sintering or casting, peaking at 4 wt% Cu. The hysteresis loop area decreases with Cu content; ≥4 wt% Cu exhibit narrow loops and low magnetic susceptibility, satisfying Class I MRI compatibility requirements. ≥4 wt% Cu achieve &gt;99% antibacterial efficacy against <em>E. coli</em> and <em>S. aureus</em>. The alloys also demonstrate good cytocompatibility and osteogenic differentiation of MC3T3-E1 cells. This study advances the design of structure–performance–function–integrated multifunctional Fe–Mn–Cu alloys for biomedical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11353-11370"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: SSP–CG scaffolds: a synergistic approach to enhance wound healing and tissue repair","authors":"Tasaduq Manzoor, Lateef Ahmad Dar, Yaawar Bashir Mir, Showkat Ahmad Shah, Sheikh F. Ahmad, Meena Godha and Syed Mudasir Ahmad","doi":"10.1039/D5TB90144H","DOIUrl":"10.1039/D5TB90144H","url":null,"abstract":"<p >Correction for ‘SSP–CG scaffolds: a synergistic approach to enhance wound healing and tissue repair’ by Tasaduq Manzoor <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2025, <strong>13</strong>, 9486–9497, https://doi.org/10.1039/D5TB00598A.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 11087-11087"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90144h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A copper sulfide/glucose oxidase/elesclomol nanoplatform for photothermal enhanced copper-induced toxicity/chemodynamic tumor combination therapy","authors":"Yuxuan Qin, Qihang Zheng, Si Shi, Chen Wang, Peng Zhang, Zhuoyin Liu, Baizhu Chen and Jie Liu","doi":"10.1039/D5TB01397F","DOIUrl":"10.1039/D5TB01397F","url":null,"abstract":"<p >Despite being more effective than single treatments for cancer, combination therapy poses a challenge in integrating multiple modalities. In this study, we propose a nanoplatform (CuS@GOx@ES) that integrates chemodynamic therapy (CDT), starvation therapy (ST), photothermal therapy (PTT), and copper-induced toxicity for enhanced cancer treatment. CuS nanoparticles, with their large surface area, are ideal for CDT, while glucose oxidase (GOx) depletes tumor glucose for ST and catalyzes H<small>₂</small>O<small>₂</small> production for a Fenton-like reaction. The glucose depletion generates gluconic acid, which accelerates CuS degradation and Cu<small>²⁺</small> release, enhancing both CDT and copper-induced toxicity. CuS also exhibits excellent photothermal properties and enhances PTT under 808 nm NIR irradiation. The increased temperature further amplifies the effects of CDT and copper-induced toxicity. Additionally, CuS serves as an exogenous source of copper, releasing Cu<small>²⁺</small> into the tumor microenvironment (TME), where it binds to the copper ion carrier ES for targeted delivery to tumor cells, inducing copper-induced toxicity and tumor cell death. The CuS@GOx@ES nanoplatform effectively combines CDT, PTT, ST, and copper-induced toxicity, creating a synergistic effect where the treatments enhance each other to achieve superior therapeutic outcomes.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11242-11254"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovations in additive manufacturing approaches for the fabrication of advanced drug delivery platforms, biomimetics, and predictive 3D microphysiological interfaces","authors":"Anushikha Ghosh, Arka Sanyal, Mamta Kumari, Souvik Mukerjee, Santanu Kaity and Subhadeep Roy","doi":"10.1039/D5TB01170A","DOIUrl":"10.1039/D5TB01170A","url":null,"abstract":"<p >Additive manufacturing (AM) has emerged as a transformative technology in personalized healthcare, particularly through its applications in targeted drug delivery and the development of microphysiological systems, potentiating a paradigm shift in healthcare towards a personalized intervention. This article explores how AM techniques, such as 3D printing, enable the creation of highly customized drug delivery systems and complex microphysiological models that can be translated into personalized healthcare solutions. By leveraging the precision and versatility of A, researchers and clinicians can design drug delivery vehicles attuned to patient needs, enhancing therapeutic efficacy and minimizing side effects. Additionally, AM facilitates the development of sophisticated microphysiological systems that simulate human tissues and organs, offering invaluable tools for drug testing, surgical planning, disease modelling, and personalized organ transplantation. This review discusses the latest advancements in such AM technologies, highlights key challenges and opportunities in integrating AM with personalized healthcare, and envisions future directions for research and clinical applications. Through a detailed examination of current methodologies and case studies, the article underscores the potential of AM to revolutionize personalized medicine by providing more effective, individualized treatment solutions and improving our understanding of futuristic healthcare.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 11928-11970"},"PeriodicalIF":6.1,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A dual-network supramolecular hydrogel dressing encapsulating Cu/EGCG nanoenzyme and glucose oxidase for closed cascade catalytic therapy of diabetic wounds","authors":"Wenli Yu, Zengzhe Liu, Shihua Mao, Lijun Hu, Yue Xi, Gaopeng Wang, Guoli Yang and Jintao Yang","doi":"10.1039/D5TB01508A","DOIUrl":"10.1039/D5TB01508A","url":null,"abstract":"<p >Poor diabetic wound healing represents a significant threat to public health. Key obstacles include heightened oxidative stress resulting from the hyperglycemic microenvironment and increased susceptibility to bacterial infections. These factors synergistically exacerbate one another, creating a self-perpetuating cycle that hampers healing. Despite advancements in wound care, developing effective strategies to simultaneously mitigate these interconnected issues and disrupt the detrimental loop remains a critical challenge. Herein, we developed a multifunctional hydrogel dressing (PACN@CG) with glucose-depleting, reactive oxygen species (ROS)-scavenging and antibacterial properties, consisting of a double-network hydrogel, copper-based nanoenzyme and glucose oxidase (GOx), forming a combination therapy system for diabetic wound treatment. The integration of covalent and non-covalent bonds within the hydrogel endows it with a range of exceptional properties, including injectability, mechanical robustness, self-healing capability, strong biological adhesion, and biodegradability. The synergistic cascade enzyme system formed by the nanoenzyme and GOx enables self-regulated glucose depletion and ROS scavenging, thereby modulating the diabetic microenvironment while enhancing antibacterial efficacy. The efficacy of the PACN@CG hydrogel in enhancing diabetic wound healing was demonstrated using full-thickness skin wound models in diabetic mice. Consequently, this hydrogel dressing successfully reestablishes tissue redox homeostasis and promotes wound healing, presenting a highly promising approach for the treatment of diabetic wounds.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 11075-11086"},"PeriodicalIF":6.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colorimetric pH-responsive nanofibrous hydrogels for in vitro monitoring of wound infection","authors":"Nadia Banitorfi Hoveizavi, Farzaneh Alihosseini, Sandro Lehner, Philipp Meier and Sabyasachi Gaan","doi":"10.1039/D5TB01305D","DOIUrl":"10.1039/D5TB01305D","url":null,"abstract":"<p >Effective wound management is crucial for improving patient outcomes, particularly through timely detection of infections and monitoring of wound conditions. Addressing this critical need, this research develops nanofibrous hydrogels integrated with an indicator dye for real-time monitoring of wounds <em>via</em> a colorimetric method. A new double network nanofibrous hydrogels based on polyvinyl alcohol (PVA) and a phosphine oxide-based pH-sensitive hydrogel (namely PVA/Gel-A) with improved properties were produced through electrospinning. Their properties were examined through SEM, ICP-OES, FTIR, surface zeta potential, and mechanical analysis. Scanning electron microscopy and Brunauer–Emmett–Teller analysis confirmed the presence of smooth, bead free nanofibers with a mesoporous structure. The swelling ratio and surface zeta potential analysis further demonstrated the presence of anionic-cationic interpenetrating polymer networks (IPNs) in PVA/Gel-A compared to pristine PVA and Gel-A alone. Increasing the Gel-A content enhances moisture absorption in a dual system of PVA/Gel-A nanofibrous hydrogels. Compared to pristine PVA nanofibers, the PVA/Gel-A (1 : 1) nanofibers displayed enhancements in elastic modulus, tensile strength, and elongation of 216%, 154.5%, and 58%, respectively. It shows considerable strength while maintaining ductility, which is essential for flexible and durable applications. Then, the dye-doped PVA/Gel-A nanofibrous hydrogels, using bromothymol blue (BTB) as a pH-sensitive dye, were fabricated with and without a complexing agent. Their colorimetric and release behaviors were evaluated at different pH levels. The cationic complexing agent effectively prevented dye leaching, releasing less than 10% and ensuring chemical stability and accurate pH sensing. These IPNs can visibly indicate wound infections, resulting in the development of colorimetric nanofibrous hydrogels that monitor pH variations for smart wound dressing applications. <em>In vitro</em> cytotoxicity assessment applying keratinocytes demonstrates no toxic effects, underscoring their potential for safe clinical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11621-11639"},"PeriodicalIF":6.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01305d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From fundamentals to applications: magnetic nanoparticles for MRI imaging and NIR-induced thermal activation in tissue-mimicking environments","authors":"Radu Lapusan, Andreea Balmus, Radu Fechete, Bogdan Viorel Neamtu, Jessica Ponti, Raluca Borlan and Monica Focsan","doi":"10.1039/D5TB01160D","DOIUrl":"10.1039/D5TB01160D","url":null,"abstract":"<p >Magnetic nanoparticles are widely explored in biomedical applications, particularly as MRI contrast agents and for magnetic hyperthermia. However, their photothermal capabilities under near-infrared (NIR) irradiation remain underexplored in realistic, tissue-like environments. This study provides a comprehensive assessment of ultrasmall Fe<small>₃</small>O<small>₄</small> nanoparticles (9.23 ± 2.97 nm) in 3D agarose-based tissue-mimicking phantoms, integrating their imaging and photothermal properties under clinically relevant conditions. Photothermal performance was tested under 850, 970, and 1100 nm NIR light, with 970 nm showing optimal efficiency (71.59%) and a penetration depth of 2.1 cm. With a high saturation magnetization of approximately 52.4 emu g<small>⁻¹</small>, the nanoparticles were evaluated as MRI contrast nanoagents, showing notable T1–T2 contrast enhancement across various concentrations. Their performance was systematically compared with the commercial agent Gadovist through magnetic resonance relaxometry, high-field preclinical MRI at 11.7 T, and clinical MRI at 1.5 T, providing a comprehensive assessment across multiple imaging platforms and concentration ranges. While this study does not include biological <em>in vitro</em> or <em>in vivo</em> models, the use of phantoms replicating tissue optical and thermal properties, combined with clinical imaging systems and safety-compliant irradiation, creates a high-fidelity platform for translational evaluation. These results support the development of dual-mode theranostic platforms and lay the groundwork for future <em>in vivo</em> studies of MRI-guided photothermal cancer therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12056-12072"},"PeriodicalIF":6.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01160d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145025039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A near-infrared light absorbable hydrogel with antibacterial effect for mild photothermal regeneration of infected wounds","authors":"Kiyan Musaie, Mostafa Qahremani, Shima Ebadi, Hooman Haghighi, Vahideh Nosrati Siahmazgi, Samin Abbaszadeh, Mohammad Reza Eskandari, Marja Slomp, Jelly Atema-Smit, Hélder A. Santos and Mohammad-Ali Shahbazi","doi":"10.1039/D5TB01346A","DOIUrl":"10.1039/D5TB01346A","url":null,"abstract":"<p >Bacterial wounds are currently a growing concern in clinical practice, with the rising challenge posed by antibiotic resistance and inflammation. Traditional photothermal therapy (PTT) presents great efficiency in treating infected wounds; however, it has the limitation of thermal damage to healthy tissues. To overcome this challenge, the strategy of mild-PTT is proposed using hyaluronic acid-coated bismuth sulfide (Bi<small>₂</small>S<small>₃</small>) nanoparticles (BiH NPs) alongside allantoin within gelatin/sodium alginate-based hydrogel formulation to eliminate bacterial infections and facilitate the wound healing procedure. BiH NP as a photothermal agent is synthesized <em>via</em> a facile and environmentally friendly method with excellent biocompatibility and high photothermal efficiency. Our formulation demonstrated good mechanical resistance with high recoverable compressibility and favorable bactericidal effects on <em>Escherichia coli</em> and <em>Staphylococcus aureus</em> bacteria. Moreover, as a multifunctional system, it accelerates wound healing in non-infected and infected full-thickness wound models with desirable <em>in vitro</em> and <em>in vivo</em> biocompatibility. With the simple preparation procedure, potent antibacterial effect, and high photothermal efficiency, this hydrogel emerges as a promising candidate for the treatment of infected wounds.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11750-11766"},"PeriodicalIF":6.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01346a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functionalized nanoporous architectures derived from sol–gel processes for advanced biomedical applications","authors":"Piumika Yapa and Imalka Munaweera","doi":"10.1039/D5TB00958H","DOIUrl":"10.1039/D5TB00958H","url":null,"abstract":"<p >The sol–gel method is a highly versatile and precise technique, making it a powerful tool for the synthesis and functionalization of nanoporous materials that play a critical role in advancing biomedical applications. Nanoporous structures, due to their unique pore architectures and high surface areas, offer significant advantages in drug delivery systems, tissue engineering, biosensing, and diagnostic technologies. These materials can efficiently encapsulate and release bioactive compounds, such as proteins, nucleic acids, and chemotherapeutic agents, making them ideal candidates for targeted therapies. The sol–gel process enables the tailored design of nanoporous materials with adjustable pore sizes, surface chemistry, and electrostatic properties, enhancing their compatibility with biological systems. Functionalization techniques, including PEGylation and surface modification with targeting ligands or bioactive molecules, further enhance their therapeutic and diagnostic potential by allowing precise targeting, reducing immune responses, and prolonging circulation times. Nanoporous materials also hold great promise in tissue engineering, where they can serve as scaffolds that mimic the extracellular matrix, supporting cell adhesion, differentiation, and tissue regeneration. Additionally, their large surface areas facilitate biomolecule immobilization, enabling the development of sensitive biosensors and offering advancements in disease detection. This paper provides a comprehensive review of the sol–gel method for synthesizing and functionalizing nanoporous structures, underscoring their significant biomedical applications. It also delves into their promising future potential in revolutionizing drug delivery, advancing tissue engineering, and enhancing diagnostic systems.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 10715-10742"},"PeriodicalIF":6.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}