Journal of Materials Chemistry B最新文献_第3页

Design and characterization of β-tricalcium phosphate-based self-passivating coatings on magnesium alloys† 基于β-磷酸三钙的镁合金自钝化涂层的设计与表征

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-24 DOI: 10.1039/D4TB01214C

Erdem Şahin, Roberta Ruggiero, Marco Tatullo, Francesco Paduano, Meltem Alp and Ahmed Şeref

{"title":"Design and characterization of β-tricalcium phosphate-based self-passivating coatings on magnesium alloys†","authors":"Erdem Şahin, Roberta Ruggiero, Marco Tatullo, Francesco Paduano, Meltem Alp and Ahmed Şeref","doi":"10.1039/D4TB01214C","DOIUrl":"10.1039/D4TB01214C","url":null,"abstract":" Background: Magnesium alloys degrade rapidly in salt solutions, which limits their use without passivating treatments. AZ31 alloy is particularly promising for implant applications owing to its biodegradability and mechanical properties, necessitating effective corrosion-resistant coatings. Aim: In this study, a self-passivating reactive coating was designed and evaluated for AZ31 magnesium alloy plates using β-tricalcium phosphate (TCP) to enhance corrosion resistance and biocompatibility. Methods: Solutions of TCP, trisodium citrate, magnesium nitrate, hydroxyethyl cellulose (HEC), and sodium chloride were used to dip-coat AZ31 plates. The coated samples were immersed in 3.5 wt% NaCl solution. Phase evolution was analysed using gravimetry, X-ray diffraction (XRD), energy-dispersive X-ray (EDX) spectroscopy, and scanning electron microscopy (SEM). The biological response of the coated samples was evaluated through MTT and resazurin assays. Results: The coating formed a stable TCP/HEC layer that gradually dissolved over two weeks, converting the surface to magnesium hydroxide, magnesium oxychloride, and magnesium phosphate phases. The formation of brucite, responsible for passivation in the long term, was observed. The coating effectively prevented excessive magnesium oxychloride formation and stabilised magnesium hydroxide after one week. Biological characterization indicated that the coating on AZ31 is safe on the Saos-2 and L929 cell lines. Conclusion: The TCP-based coating enhances the corrosion resistance of AZ31 alloy in salt solutions, promoting passivating phases and limiting corrosive products, thereby ameliorating biocompatibility issues. This coating demonstrates substantial potential for extending the longevity and functionality of magnesium alloy implants.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 44","pages":" 11477-11490"},"PeriodicalIF":6.1,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142484341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation 抗菌功能化碳点及其在细菌感染和炎症中的应用。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-11 DOI: 10.1039/D3TB01543B

Meng Fang, Liping Lin, Muyue Zheng, Wei Liu and Rongguang Lin

{"title":"Antibacterial functionalized carbon dots and their application in bacterial infections and inflammation","authors":"Meng Fang, Liping Lin, Muyue Zheng, Wei Liu and Rongguang Lin","doi":"10.1039/D3TB01543B","DOIUrl":"10.1039/D3TB01543B","url":null,"abstract":"Bacterial infections and inflammation pose a severe threat to human health and the social economy. The existence of super-bacteria and the increasingly severe phenomenon of antibiotic resistance highlight the development of new antibacterial agents. Due to low cytotoxicity, high biocompatibility, and different antibacterial mechanisms from those for antibiotics, functionalized carbon dots (FCDs) promise a new platform for the treatment of bacterial infectious diseases. However, few articles have systematically sorted out the available antibacterial mechanisms for FCDs and their application in the treatment of bacterial inflammation. This review focuses on the available antibacterial mechanisms for FCDs, including covalent and non-covalent interactions, reactive oxygen species, photothermal therapy, and size effect. Meanwhile, the design of antibacterial FCDs is introduced, including surface modification, doping, and combination with other nanomaterials. Furthermore, this review specifically concentrates on the research advances of antibacterial FCDs in the treatment of bacterial inflammation. Finally, the advantages and challenges of applying FCDs in practical antimicrobial applications are discussed.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9386-9403"},"PeriodicalIF":7.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10280438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expression of concern: Poly(lactide-co-glycolide) grafted hyaluronic acid-based electrospun fibrous hemostatic fragments as a sustainable anti-infection and immunoregulation material 关注表达:聚乳酸-羟基乙酸酯(lladide -co-glycolide)移植透明质酸基静电纺纤维止血碎片作为可持续的抗感染和免疫调节材料

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-07 DOI: 10.1039/D3TB90162A

Wen Liu, Guanghui Xi, Xiao Yang, Xiao Hao, Mingshan Wang, Yakai Feng, Hao Chen and Changcan Shi

引用次数: 0

Correction: A novel PEC and ECL bifunctional aptasensor based on V2CTx MXene-derived MOF embedded with silver nanoparticles for selectively aptasensing miRNA-126 修正:一种新型的PEC和ECL双功能适配体传感器，基于V2CTx mxene衍生的MOF，嵌入银纳米粒子，用于选择性地适配miRNA-126

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-07 DOI: 10.1039/D3TB90165C

Yu Li, Shuai Zhang, Mengfei Wang, Chuanpan Guo, Nan Zhou and Zhihong Zhang

引用次数: 0

Expression of concern: Bacterial infection microenvironment-responsive enzymatically degradable multilayer films for multifunctional antibacterial properties 关注表达:细菌感染微环境反应性酶降解多层膜的多功能抗菌性能

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-07 DOI: 10.1039/D3TB90161K

Qingqing Yao, Zi Ye, Lin Sun, Yingying Jin, Qingwen Xu, Mei Yang, Yi Wang, Yunlong Zhou, Jian Ji, Hao Chen and Bailiang Wang

引用次数: 0

Correction: Folic acid as a versatile motif to construct molecular hydrogelators through conjugations with hydrophobic therapeutic agents 更正:叶酸作为一个通用基序，通过与疏水治疗剂偶联来构建分子凝胶

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-06 DOI: 10.1039/D3TB90164E

Xingyi Li, Chengbiao Yang, Zhaoliang Zhang, Zhidan Wu, Yun Deng, Gaolin Liang, Zhimou Yang and Hao Chen

引用次数: 0

Expression of concern: In vitro and in vivo evaluation of xanthan gum–succinic anhydride hydrogels for the ionic strength-sensitive release of antibacterial agents 关注表达:黄原胶-丁二酸酐水凝胶对抗菌药物离子强度敏感释放的体外和体内评价

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-06 DOI: 10.1039/D3TB90163G

Bailiang Wang, Yuemei Han, Quankui Lin, Huihua Liu, Chenghui Shen, Kaihui Nan and Hao Chen

引用次数: 0

Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy 当前新兴的阿尔茨海默病新疗法和磁机械力疗法的未来前景。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-05 DOI: 10.1039/D3TB01629C

Yajing Shen, Meng Wang, Shutang Li and Jinfei Yang

{"title":"Current emerging novel therapies for Alzheimer's disease and the future prospects of magneto-mechanical force therapy","authors":"Yajing Shen, Meng Wang, Shutang Li and Jinfei Yang","doi":"10.1039/D3TB01629C","DOIUrl":"10.1039/D3TB01629C","url":null,"abstract":"Alzheimer's disease (AD) is the most common neurodegenerative disease among the elderly, and the morbidity increases with the aging population aggravation. The clinical symptoms of AD mainly include cognitive impairment and memory loss, which undoubtedly bring a huge burden to families and society. Currently, the drugs in clinical use only improve the symptoms of AD but do not cure or prevent the progression of the disease. Therefore, it is urgent for us to develop novel therapeutic strategies for effective AD treatment. To provide a better theoretical basis for exploring novel therapeutic strategies in future AD treatment, this review introduces the recent AD treatment technologies from three aspects, including nanoparticle (NP) based drug therapy, biological therapy and physical therapy. The nanoparticle-mediated therapeutic approaches at the nanomaterial–neural interface and biological system are described in detail, and in particular the magneto-regulated strategies by magnetic field actuating magnetic nanoparticles are highlighted. Promising application of magneto-mechanical force regulated strategy in future AD treatment is also addressed, which offer possibilities for the remote manipulation in a precise manner. In the future, it may be possible for physicians to realize a remote, precise and effective therapy for AD using magneto-mechanical force regulated technology based on the combination of magnetic nanoparticles and an external magnetic field.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9404-9418"},"PeriodicalIF":7.0,"publicationDate":"2023-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10287088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment 聚甲基丙烯酸甲酯骨水泥治疗骨肿瘤的综合评价和先进改性。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-04 DOI: 10.1039/D3TB01494K

Bo Chao, Jianhang Jiao, Lili Yang, Yang Wang, Tong Yu, He Liu, Han Zhang, Mufeng Li, Wenjie Wang, Xiangran Cui, Shangyu Du, Zhonghan Wang and Minfei Wu

{"title":"Comprehensive evaluation and advanced modification of polymethylmethacrylate cement in bone tumor treatment","authors":"Bo Chao, Jianhang Jiao, Lili Yang, Yang Wang, Tong Yu, He Liu, Han Zhang, Mufeng Li, Wenjie Wang, Xiangran Cui, Shangyu Du, Zhonghan Wang and Minfei Wu","doi":"10.1039/D3TB01494K","DOIUrl":"10.1039/D3TB01494K","url":null,"abstract":"Bone tumors are invasive diseases with a tendency toward recurrence, disability, and high mortality rates due to their grievous complications. As a commercial polymeric biomaterial, polymethylmethacrylate (PMMA) cement possesses remarkable mechanical properties, injectability, and plasticity and is, therefore, frequently applied in bone tissue engineering. Numerous positive effects in bone tumor treatment have been demonstrated, including biomechanical stabilization, analgesic effects, and tumor recurrence prevention. However, to our knowledge, a comprehensive evaluation of the application of the PMMA cement in bone tumor treatment has not yet been reported. This review comprehensively evaluates the efficiency and complications of the PMMA cement in bone tumor treatment, for the first time, and introduces advanced modification strategies, providing an objective and reliable reference for the application of the PMMA cement in treating bone tumors. We have also summarized the current research on modifications to enhance the anti-tumor efficacy of the PMMA cement, such as drug carriers and magnetic hyperthermia.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9369-9385"},"PeriodicalIF":7.0,"publicationDate":"2023-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/tb/d3tb01494k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10246156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Remodeling arteries: studying the mechanical properties of 3D-bioprinted hybrid photoresponsive materials† 重塑动脉：研究3D生物打印混合光响应材料的力学性能。

IF 7 3区医学

Journal of Materials Chemistry B Pub Date : 2023-09-01 DOI: 10.1039/D3TB01480K

Uxue Aizarna-Lopetegui, Clara García-Astrain, Carlos Renero-Lecuna, Patricia González-Callejo, Irune Villaluenga, Miguel A. del Pozo, Miguel Sánchez-Álvarez, Malou Henriksen-Lacey and Dorleta Jimenez de Aberasturi

{"title":"Remodeling arteries: studying the mechanical properties of 3D-bioprinted hybrid photoresponsive materials†","authors":"Uxue Aizarna-Lopetegui, Clara García-Astrain, Carlos Renero-Lecuna, Patricia González-Callejo, Irune Villaluenga, Miguel A. del Pozo, Miguel Sánchez-Álvarez, Malou Henriksen-Lacey and Dorleta Jimenez de Aberasturi","doi":"10.1039/D3TB01480K","DOIUrl":"10.1039/D3TB01480K","url":null,"abstract":"3D-printed cell models are currently in the spotlight of medical research. Whilst significant advances have been made, there are still aspects that require attention to achieve more realistic models which faithfully represent the in vivo environment. In this work we describe the production of an artery model with cyclic expansive properties, capable of mimicking the different physical forces and stress factors that cells experience in physiological conditions. The artery wall components are reproduced using 3D printing of thermoresponsive polymers with inorganic nanoparticles (NPs) representing the outer tunica adventitia, smooth muscle cells embedded in extracellular matrix representing the tunica media, and finally a monolayer of endothelial cells as the tunica intima. Cyclic expansion can be induced thanks to the inclusion of photo-responsive plasmonic NPs embedded within the thermoresponsive ink composition, resulting in changes in the thermoresponsive polymer hydration state and hence volume, in a stimulated on–off manner. By changing the thermoresponsive polymer composition, the transition temperature and pulsatility can be efficiently tuned. We show the direct effect of cyclic expansion and contraction on the overlying cell layers by analyzing transcriptional changes in mechanoresponsive mesenchymal genes associated with such microenvironmental physical cues. The technique described herein involving stimuli-responsive 3D printed tissue constructs, also described as four- dimensional (4D) printing, offers a novel approach for the production of dynamic biomodels.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 39","pages":" 9431-9442"},"PeriodicalIF":7.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2023/tb/d3tb01480k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10127072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0