Journal of Materials Chemistry B最新文献_第3页

Self-assembled thin films as alternative surface textures in assistive aids with users who are blind 自组装薄膜作为盲人辅助工具的替代表面纹理

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-05 DOI: 10.1039/d4tb01646g

Zachary Swain, Maryanne Derkaloustian, Kayla A. Hepler, Abigail Nolin, Vidhika S. Damani, Pushpita Bhattacharyya, Tulaja Shrestha, Jared Medina, Laure V. Kayser, Charles B. Dhong

{"title":"Self-assembled thin films as alternative surface textures in assistive aids with users who are blind","authors":"Zachary Swain, Maryanne Derkaloustian, Kayla A. Hepler, Abigail Nolin, Vidhika S. Damani, Pushpita Bhattacharyya, Tulaja Shrestha, Jared Medina, Laure V. Kayser, Charles B. Dhong","doi":"10.1039/d4tb01646g","DOIUrl":"https://doi.org/10.1039/d4tb01646g","url":null,"abstract":"Current tactile graphics primarily render tactile information for blind users through physical features, such as raised bumps or lines. However, the variety of distinctive physical features that can be created is effectively saturated, and alternatives to these physical features are not currently available for static tactile aids. Here, we explored the use of chemical modification through self-assembled thin films to generate distinctive textures in tactile aids. We used two silane precursors, n-butylaminopropyltrimethoxysilane and n-pentyltrichlorosilane, to coat playing card surfaces and investigated their efficacy as a tactile coating. We verified the surface coating process and examined their durability to repeated use by traditional materials characterization and custom mesoscale friction testing. Finally, we asked participants who were both congenitally blind and braille-literate to sort the cards based on touch. We found that participants were able to identify the correct coated card with 82% accuracy, which was significantly above chance, and two participants achieved 100% accuracy. This success with study participants demonstrates that surface coatings and surface modifications might augment or complement physical textures in next-generation tactile aids.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible and antibacterial conductive hydrogels based on silk fibroin/polyaniline/AgNPs for motion sensing and wound healing promotion under electrical stimulation 基于丝纤维素/聚苯胺/AgNPs 的柔性抗菌导电水凝胶，可在电刺激下用于运动传感和促进伤口愈合

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-05 DOI: 10.1039/d4tb01505c

Ruiqi Liu, Siwei Bi, Linna Zhang, Xiaoyi Li, Kang Dai, Haibo Wang, Zhenyu Zhang, Jun Gu

{"title":"Flexible and antibacterial conductive hydrogels based on silk fibroin/polyaniline/AgNPs for motion sensing and wound healing promotion under electrical stimulation","authors":"Ruiqi Liu, Siwei Bi, Linna Zhang, Xiaoyi Li, Kang Dai, Haibo Wang, Zhenyu Zhang, Jun Gu","doi":"10.1039/d4tb01505c","DOIUrl":"https://doi.org/10.1039/d4tb01505c","url":null,"abstract":"Flexible conductive hydrogel-based electronic skin (E-skin) for simultaneous biotherapeutics and sensing applications is one of the current research directions. In this study, conductive and homogeneous silk fibroin/polyaniline/AgNP complexes (SPAg complexes) were prepared with the assistance of silk fibroin, which greatly optimized the compatibility of PANI with the hydrogel matrix. Then, SPAg was introduced into the covalently crosslinked polymer network to prepare poly(acrylamide-co-sulfobetaine methacrylate) – SPAg hydrogels (labeled as PSPAg hydrogels). The PSPAg hydrogels exhibit good biocompatibility, excellent mechanical properties, superb adhesive performance, and fantastic sensing capabilities. Being connected to a smartphone via a Bluetooth system, the SPAg hydrogel-based E-skin was employed to accurately monitor human movements including vigorous joint movements and subtle facial micro-expressions. Finally, benefiting from the synergistic effect of antimicrobial and exogenous electrical stimulation, through promoting angiogenesis and accelerating collagen production in diabetic wounds, PSPAg E-skin successfully facilitates rapid diabetic wound healing. Therefore, the multifunctional PSPAg hydrogel-based E-skin shows great promise for applications in wearable devices and bioelectronics.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fast-response fiber organic electrochemical transistor with vertical channel design for electrophysiological monitoring† 采用垂直沟道设计的快速响应光纤有机电化学晶体管，用于电生理监测。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/D4TB01426J

Jiawei Chen, Yuan Fang, Jianyou Feng, Xiang Shi, Jinyan Li, Shuzhuang Wang, Songlin Zhang, Huisheng Peng and Xuemei Sun

{"title":"Fast-response fiber organic electrochemical transistor with vertical channel design for electrophysiological monitoring†","authors":"Jiawei Chen, Yuan Fang, Jianyou Feng, Xiang Shi, Jinyan Li, Shuzhuang Wang, Songlin Zhang, Huisheng Peng and Xuemei Sun","doi":"10.1039/D4TB01426J","DOIUrl":"10.1039/D4TB01426J","url":null,"abstract":"Fiber organic electrochemical transistors (OECTs) hold significant promise for in vivo bio-signal amplification due to their minimally invasive and seamless integration with biological tissues. However, their use in monitoring rapid physiological changes, such as electrophysiological signals, has been constrained by slow response time, arising from their extensive channel dimensions. Here, we introduce a novel fiber OECT designed with a micro-scale vertical channel (F-vOECT) that substantially reduces the response time by an order of magnitude to 12 ms and achieves a maximum transconductance of 16 mS at zero gate bias, marking a substantial improvement over previous fiber OECTs. This compact and flexible fiber device demonstrates robust performance under cyclic switching, dynamic deformation and exhibits excellent biocompatibility. When subcutaneously implanted in rats, the F-vOECT enables stable, continuous electrocardiogram monitoring for 7 days, successfully identifying episodes of atrioventricular block. These capabilities illustrate its potential for clinical electrophysiological diagnostics. The design strategy of F-vOECT opens new avenues for developing fast-responsive fiber bioelectronic devices.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.1,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142157058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New insights into the photophysical properties and interaction mechanisms of Janus green blue dye with polyanions and its applications in colorimetric visualization of loop-mediated isothermal amplification and polymerase chain reaction 对 Janus 绿蓝色染料的光物理特性和与聚阴离子相互作用机制的新认识及其在环介导等温扩增和聚合酶链反应比色可视化中的应用

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01623h

Arumugam Selva Sharma, Sung Min Ryou, Ji Hyeok Lee, Nae Yoon Lee

{"title":"New insights into the photophysical properties and interaction mechanisms of Janus green blue dye with polyanions and its applications in colorimetric visualization of loop-mediated isothermal amplification and polymerase chain reaction","authors":"Arumugam Selva Sharma, Sung Min Ryou, Ji Hyeok Lee, Nae Yoon Lee","doi":"10.1039/d4tb01623h","DOIUrl":"https://doi.org/10.1039/d4tb01623h","url":null,"abstract":"In this investigation, the photophysical properties and interaction mechanisms of Janus green blue (JGB) dye with polyanions were systematically studied using spectroscopic techniques. The absorption spectral analysis revealed that JGB binds cooperatively to sodium alginate, leading to dye stacking along the polymer chain. The interaction of JGB dye with DNA was characterized by the emergence of a metachromatic peak at 564 nm, indicating the formation of dye aggregates. The analysis of absorption data reveals that JGB dye interacts with DNA at multiple binding sites, including at least one high-affinity site. The AutoDock Vina based blind docking approach was used to analyze the most probable binding location of JGB dye in DNA. By making use of the DNA-induced metachromasia, a colorimetric approach was developed for the visualization of loop-mediated isothermal amplification (LAMP) and polymerase chain reaction (PCR). The LAMP-colorimetric assay, targeting the Streptococcus pneumoniae gene, demonstrated a noticeable colour change with a detection limit of 1 pg μL−1. The practical applicability was validated by detecting S. pneumoniae in artificial urine. In addition to LAMP, we tested the JGB dye based colorimetric assay for applicability in PCR reactions. The colorimetric PCR assay using the metal-responsive transcription factor (MTF-1) gene achieved a detection limit as low as 0.1 pg μL−1. The study highlights the potential of DNA binding metachromic dye to significantly enhance colorimetric assays, offering a robust and sensitive tool for molecular diagnostics.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in fluorescent probes for fatty liver imaging by detecting lipid droplets 通过检测脂滴进行脂肪肝成像的荧光探针的最新进展

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01741b

Long He, Hang Li, Yao Tang, Tian-Bing Ren, Lin Yuan

引用次数: 0

Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging 用于体内高场磁共振成像和 CT 成像的双模造影剂--钨酸钠镧系纳米粒子

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01157k

Elisabet Gómez-González, Carlos Caro, Nuria O. Núñez, Daniel González-Mancebo, Jesús D. Urbano-Gámez, Maria L. García-Martín, Manuel Ocaña

{"title":"Sodium lanthanide tungstate-based nanoparticles as bimodal contrast agents for in vivo high-field MRI and CT imaging","authors":"Elisabet Gómez-González, Carlos Caro, Nuria O. Núñez, Daniel González-Mancebo, Jesús D. Urbano-Gámez, Maria L. García-Martín, Manuel Ocaña","doi":"10.1039/d4tb01157k","DOIUrl":"https://doi.org/10.1039/d4tb01157k","url":null,"abstract":"Research on high-field magnetic resonance imaging (HF-MRI) has been increased in recent years, aiming to improve diagnosis accuracy by increasing the signal-to-noise ratio and hence image quality. Conventional contrast agents (CAs) have important limitations for HF-MRI, with the consequent need for the development of new CAs. Among them, the most promising alternatives are those based on Dy3+ or Ho3+ compounds. Notably, the high atomic number of lanthanide cations would bestow a high capability for X-ray attenuation to such Dy or Ho-based compounds, which would also allow them to be employed as CAs for X-ray computed tomography (CT). In this work, we have prepared uniform NaDy(WO4)2 and NaHo(WO4)2 nanoparticles (NPs), which were dispersible under conditions that mimic the physiological media and were nontoxic for cells, meeting the main requirements for their use in vivo. Both NPs exhibited satisfactory magnetic relaxivities at 9.4 T, thus making them a promising alternative to clinical CAs for HF-MRI. Furthermore, after their intravenous administration in tumor-bearing mice, both NPs exhibited significant accumulation inside the tumor at 24 h, attributable to passive targeting by the enhanced permeability and retention (EPR) effect. Therefore, our NPs are suitable for the detection of tumors through HF-MRI. Finally, NaDy(WO4)2 NPs showed a superior X-ray attenuation capability than iohexol (commercial CT CA), which, along with their high r2 value, makes them suitable as the dual-probe for both HF-MRI and CT imaging, as demonstrated by in vivo experiments conducted using healthy mice.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine–metal assembly RNA 结合肽和内体逃逸辅助肽 (L2) 通过六脒金属组装改善了 siRNA 的递送

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01433b

Yan Zhang, Li-Miao Qin, Meng-Fan Feng, Xianghui Yu, Yuqing Wu

{"title":"RNA-binding peptide and endosomal escape-assisting peptide (L2) improved siRNA delivery by the hexahistidine–metal assembly","authors":"Yan Zhang, Li-Miao Qin, Meng-Fan Feng, Xianghui Yu, Yuqing Wu","doi":"10.1039/d4tb01433b","DOIUrl":"https://doi.org/10.1039/d4tb01433b","url":null,"abstract":"Small interfering RNAs (siRNAs), comprising 21–23 nucleotides, function by complementary binding to specific mRNA sequences, thereby suppressing target protein expression. Despite their vast potential in disease therapy, siRNAs face challenges due to their susceptibility to degradation and high electronegativity, rendering them unstable in the bloodstream and impeding their passage across endothelial barriers. Moreover, successful intracellular delivery necessitates overcoming endosomal entrapment, posing a significant hurdle for carrier material development. In this study, leveraging the strong affinity of histidine oligomers (His6) for metal ions, we engineered nanoparticles (HmA) by gentle assembly with divalent zinc ions under pH = 8 conditions. We designed the RNA-binding functional peptide L2-NTD to enhance siRNA stability and delivery efficiency when complexed with HmA. The resulting siRNA+L2-NTD@HmA nanoparticles were formed via in situ encapsulation, ensuring efficient siRNA delivery into cells with minimal cytotoxicity and degradation. This approach presents a novel strategy for the design and artificial fabrication of carriers for effective RNA delivery.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel pH-responsive monomer inhibits Candida albicans via a dual antifungal mode of action 新型 pH 值响应单体通过双重抗真菌作用模式抑制白色念珠菌

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb00851k

Hao Li, Yangyang Shi, Hui Chen, Jingou Liang, Shiyong Zhang, Bolei Li, Jing Chen, Mingyun Li, Xian Peng, Xuedong Zhou, Biao Ren, Lei Cheng

{"title":"A novel pH-responsive monomer inhibits Candida albicans via a dual antifungal mode of action","authors":"Hao Li, Yangyang Shi, Hui Chen, Jingou Liang, Shiyong Zhang, Bolei Li, Jing Chen, Mingyun Li, Xian Peng, Xuedong Zhou, Biao Ren, Lei Cheng","doi":"10.1039/d4tb00851k","DOIUrl":"https://doi.org/10.1039/d4tb00851k","url":null,"abstract":"The scarcity of the antifungal drug arsenal highlights an urgent need to develop alternative treatments for candidiasis caused by Candida albicans (C. albicans). As pH is closely associated with C. albicans infection, it could be an essential target in a novel approach for designing antifungal therapy. In this study, a novel intelligent antifungal monomer, dodecylmethylaminoethyl methacrylate (DMAEM), with a pH-responsive tertiary amine group and a methacrylate-derived C<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\"/>C double bond group is developed. It is uncovered that the two functional groups of DMAEM contribute to a dual mode of action. Under acidic pH, the tertiary amine of DMAEM protonates into a cationic fungicide, sharing similar structural and functional characteristics with quaternary ammonium salts, which exerts fungicidal activity by targeting the CHK1 two-component system in C. albicans. At neutral pH, the methacrylate-derived C<img alt=\"[double bond, length as m-dash]\" border=\"0\" src=\"https://www.rsc.org/images/entities/char_e001.gif\"/>C double bond group contributes to anti-virulence activity by blocking hyphal formation. In addition, it is also identified that DMAEM suppresses filamentation by altering the extracellular vesicles of C. albicans. These findings support that the novel intelligent pH-responsive monomer could be a therapeutic candidate for treating candidiasis.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring enzyme-immobilized MOFs and their application potential: biosensing, biocatalysis, targeted drug delivery and cancer therapy 探索酶固定化 MOFs 及其应用潜力：生物传感、生物催化、靶向给药和癌症治疗

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01556h

Om Prakash, Deepika Verma, Poonam C. Singh

{"title":"Exploring enzyme-immobilized MOFs and their application potential: biosensing, biocatalysis, targeted drug delivery and cancer therapy","authors":"Om Prakash, Deepika Verma, Poonam C. Singh","doi":"10.1039/d4tb01556h","DOIUrl":"https://doi.org/10.1039/d4tb01556h","url":null,"abstract":"Enzymes are indispensable in several applications including biosensing and degradation of pollutants and in the drug industry. However, adverse conditions restrict enzymes' utility in biocatalysis due to their inherent limitations. Metal–organic frameworks (MOFs), with their robust structure, offer an innovative avenue for enzyme immobilization, enhancing their resilience against harsh solvents and temperatures. This advancement is pivotal for application in bio-sensing, bio-catalysis, and specifically, targeted drug delivery in cancer therapy, where enzyme–MOF composites enable precise therapeutic localization, minimizing the side effects of traditional treatment. The adaptable nature of MOFs enhances drug biocompatibility and availability, significantly improving therapeutic outcomes. Moreover, the integration of enzyme-immobilized MOFs into bio-sensing represents a leap forward in the rapid and accurate identification of biomarkers, facilitating early diagnosis and disease monitoring. In bio-catalysis, this synergy promotes efficient and environmentally safe chemical synthesis, enhancing reaction rates and yields and broadening the scope of enzyme application in pharmaceutical and bio-fuel production. This review article explores the immobilization techniques and their biomedical applications, specifically focusing on drug delivery in cancer therapy and bio-sensing. Additionally, it addresses the challenges faced in this expanding field.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation-induced emission silence-mediated pathogen detection using a rapidly degradable nanographene-embedded polymersome 利用可快速降解的纳米石墨烯嵌入聚合体进行聚合诱导发射沉默介导的病原体检测

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-04 DOI: 10.1039/d4tb01379d

Chia-Yi Cheng, Eldhose V. Varghese, Wen-Jyun Wang, Chia-Yu Yao, Chia-Hsiang Chen, Wei-Peng Li

{"title":"Aggregation-induced emission silence-mediated pathogen detection using a rapidly degradable nanographene-embedded polymersome","authors":"Chia-Yi Cheng, Eldhose V. Varghese, Wen-Jyun Wang, Chia-Yu Yao, Chia-Hsiang Chen, Wei-Peng Li","doi":"10.1039/d4tb01379d","DOIUrl":"https://doi.org/10.1039/d4tb01379d","url":null,"abstract":"Typical pathogen detection processes are time-consuming and require expensive equipment and professional operators, limiting their practical applicability. Developing a rapid and easy-to-read method of accurately sensing pathogenic bacteria is critical for reducing the spread and risk of infection in high-risk areas. Herein, the synthesis of nanographene (nanoG) that exhibits aggregation-induced emission (AIE) is described. The nanoG was embedded into a hydrophobic shell of poly(lactic-co-glycolic acid) (PLGA) polymersome in a double-emulsion process, significantly enhancing the nanoG luminescence under irradiation at 330 nm due to the enrichment of nanoG between the inner and outer PLGA shells. Both Gram-positive and Gram-negative bacteria can rapidly degrade the PLGA vesicular structure, leading to dispersal of the nanoG inside the shell and silencing the AIE effect. A linear relationship between the bacterial concentration and emissivity was established, and the detection limit was identified. Moreover, the polymersome has excellent selectivity for methicillin-resistant Staphylococcus aureus (MRSA) detection after a screening pretreatment of a bacterial mixture with suitable antibiotics. The AIE silencing could be observed with the naked eye in an MRSA-infected wound treated with the polymersome after 1 h of incubation, demonstrating a high potential for clinical rapid screening applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0