Journal of Materials Chemistry B最新文献_第2页

Simultaneous detection of breast cancer biomarkers HER2 and miRNA-212 based on duplex-specific nuclease signal amplification 基于双链特异性核酸酶信号放大技术同时检测乳腺癌生物标记物 HER2 和 miRNA-212

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-12 DOI: 10.1039/d4tb01845a

Miao He, Zhiqiang Hou, Feifan Yin, Wenting Cheng, Yang Xiang, Zhongyun Wang

{"title":"Simultaneous detection of breast cancer biomarkers HER2 and miRNA-212 based on duplex-specific nuclease signal amplification","authors":"Miao He, Zhiqiang Hou, Feifan Yin, Wenting Cheng, Yang Xiang, Zhongyun Wang","doi":"10.1039/d4tb01845a","DOIUrl":"https://doi.org/10.1039/d4tb01845a","url":null,"abstract":"The detection of a single biomarker is prone to false negative or false positive results. Simultaneous analysis of two biomarkers can greatly improve the accuracy of diagnosis. In this work, we designed a new method for coinstantaneous detection of two breast cancer biomarkers miRNA-21 and HER2 using the properties of duplex-specific nuclease (DSN). Cy5-labeled DNA1 and FAM-labeled DNA2 are used as signal probes to distinguish the two signals. When the sample contains the targets HER2 and miRNA-21, HER2 binds to the HER2 aptamer on the double-stranded DNA2, while miRNA-21 binds to the complementary DNA1. Then, DSN enzyme is added to cut the DNA probes adsorbed on the HER2 aptamer and miRNA-21, releasing the fluorescent groups, which can be readsorbed to the empty sites, thus repeating the cutting of the probes and producing an exponential signal amplification with two distinct fluorescent signals. The detection limits of miRNA-21 and HER2 are 1.12 pM and 0.36 ng mL−1, respectively, with linear ranges of 5 pM to 50 pM and 1 ng mL−1 to 15 ng mL−1. The method was validated in real biological samples, providing a new approach for synchronous analysis of important markers in breast cancer.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein nanopore-based sensors for public health analyte detection 基于蛋白质纳米孔的公共卫生分析物检测传感器

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-11 DOI: 10.1039/d4tb01149j

Yanhua Zhang, Chan Hu, Ronghui Liu, Shujun He, Jie Yang, Wen Yao, Yi Li, Xinrong Guo

引用次数: 0

The recent progress of bone regeneration materials containing EGCG 含有 EGCG 的骨再生材料的最新进展

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-11 DOI: 10.1039/d4tb00604f

Yaoye Zhao, Guoding Cao, Zixin Wang, Desheng Liu, Liling Ren, Dongyang Ma

{"title":"The recent progress of bone regeneration materials containing EGCG","authors":"Yaoye Zhao, Guoding Cao, Zixin Wang, Desheng Liu, Liling Ren, Dongyang Ma","doi":"10.1039/d4tb00604f","DOIUrl":"https://doi.org/10.1039/d4tb00604f","url":null,"abstract":"Epigallocatechin-3-gallate (EGCG) is the most effective active ingredient in tea polyphenols and belongs to the category of catechins. EGCG has excellent antioxidant activity, anti-inflammatory, osteogenesis-promoting, and antibacterial properties, and has been widely studied in orthopedic diseases such as osteoporosis. To reach the lesion site, achieve sustained release, promote osteogenesis, regulate macrophage polarization, and improve the physical properties of materials, EGCG needs to be cross-linked or incorporated in bone regeneration materials. This article reviews the application of bone regeneration materials combined with EGCG, including natural polymer bone regeneration materials, synthetic polymer bone regeneration materials, bioceramic bone regeneration materials, metal bone regeneration materials, hydrogel bone regeneration materials and metal–EGCG networks. In addition, the fabrication methods for the regenerated scaffolds are also elaborated in the text. To sum up, it reveals the excellent development potential of materials containing EGCG and the shortcomings of current research, which will provide important reference for the future exploration of bone regeneration materials containing EGCG.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142227030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The heterogeneity of physiological activity for chiral carbon dots derived from L/D/DL-arginine L/D/DL-精氨酸手性碳点生理活性的异质性

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-10 DOI: 10.1039/d4tb01294a

Fengyuan Liu, Jiashan Xia, Chun Tao, Changmei Chen, Xiangshu Cheng, Rongchun Yi, Lulu Wang, Yue Wang, Tao Deng

{"title":"The heterogeneity of physiological activity for chiral carbon dots derived from L/D/DL-arginine","authors":"Fengyuan Liu, Jiashan Xia, Chun Tao, Changmei Chen, Xiangshu Cheng, Rongchun Yi, Lulu Wang, Yue Wang, Tao Deng","doi":"10.1039/d4tb01294a","DOIUrl":"https://doi.org/10.1039/d4tb01294a","url":null,"abstract":"Chirality is a ubiquitous phenomenon in nature. The advent of nanomaterials has led to a gradual evolution of chiral studies from the molecular scale to the nanoscale. The emergence of carbon dots (CDs) has inaugurated a novel domain in the scientific and technological realms of carbon nanomaterials. In recent years, CDs have attracted increasing attention due to their luminescent properties, excellent biocompatibility and remarkable bioactivity. However, little attention has been paid to the chirality of the CDs and, in particular, the differences between CDs synthesized from racemic compounds and other chiral CDs, as well as the differences in the biological effects of chiral CDs, remain to be explored. Here, chiral CDs were synthesized from L-/D-/DL-arginine, and the differences in various aspects of chiral CDs were evaluated. We found that L-CDs without extreme differences in structure had brighter fluorescence and a more significant ability of NO generation and lipid droplet inhibition than the other two chiral CDs. Combined with its better drug loading and release ability, we validated its superior efficacy in tumor treatment. Therefore, this study provides a basis for further research on chiral carbon dots and their differences.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a urea-bond cleavage reaction induced by nitric oxide for fluorescence imaging 开发用于荧光成像的一氧化氮诱导的脲键裂解反应

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-10 DOI: 10.1039/d4tb01462f

Yuqing Zhang, Shushu Wang, Lina Zhang, Tao Peng

{"title":"Development of a urea-bond cleavage reaction induced by nitric oxide for fluorescence imaging","authors":"Yuqing Zhang, Shushu Wang, Lina Zhang, Tao Peng","doi":"10.1039/d4tb01462f","DOIUrl":"https://doi.org/10.1039/d4tb01462f","url":null,"abstract":"Nitric oxide (NO) is a multifunctional signalling molecule with indispensable roles in physiological processes, but its abnormal production is implicated in various disease conditions. Detecting NO is crucial for interrogating its biological roles. Although many o-phenylenediamine-based fluorescent probes have been developed, only a small fraction has been employed in vivo. Moreover, these probes largely require direct modifications of the fluorophore backbones to render NO responsiveness, which restricts the general applicability of o-phenylenediamine-based probe designs to other types of fluorophores. Here, we report the rational development, optimization, and application of a NO-induced urea-bond cleavage reaction for selective fluorescence detection and imaging of NO in living systems. Through rational design and extensive screening, we identified a 2-aminophenylurea-derived functionality that can react with NO through N-nitrosation, acyltriazole formation, and hydrolysis to induce the cleavage of the urea bond and release of the amino-containing coumarin fluorophore. By caging different amino-containing fluorophore scaffolds with the 2-aminophenylurea-derived functionality, we modularly developed a series of NO fluorescent probes with different excitation and emission profiles for the detection of NO in aqueous solutions and live cells. Among these probes, the near-infrared probe has been demonstrated to enable in vivo fluorescence visualization of elevated endogenous levels of NO in a murine inflammation model. Overall, this study provides a NO-induced urea-bond cleavage reaction and establishes the utility of this reaction for the general and modular development of NO fluorescent probes, thus opening new opportunities for studying and manipulating NO in biological systems.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dendrimer nanoclusters loaded with gold nanoparticles for enhanced tumor CT imaging and chemotherapy via an amplified EPR effect 负载金纳米粒子的树枝状聚合物纳米团簇通过放大的 EPR 效应增强肿瘤 CT 成像和化疗效果

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-09 DOI: 10.1039/d4tb01747a

Shewaye Lakew Mekuria, Gaoming Li, Zhiqiang Wang, Wubshet Mekonnen Girma, Aiyu Li, Meijuan He, Han Wang, Meera Moydeen Abdul Hameed, Mohamed EL-Newehy, Xiangyang Shi, Mingwu Shen

{"title":"Dendrimer nanoclusters loaded with gold nanoparticles for enhanced tumor CT imaging and chemotherapy via an amplified EPR effect","authors":"Shewaye Lakew Mekuria, Gaoming Li, Zhiqiang Wang, Wubshet Mekonnen Girma, Aiyu Li, Meijuan He, Han Wang, Meera Moydeen Abdul Hameed, Mohamed EL-Newehy, Xiangyang Shi, Mingwu Shen","doi":"10.1039/d4tb01747a","DOIUrl":"https://doi.org/10.1039/d4tb01747a","url":null,"abstract":"The design of efficient multifunctional nanomedicines to overcome adverse side effects within biological systems and to achieve desirable computed tomography (CT) imaging and therapeutics of tumors remains challenging. Herein, we report the design of multifunctional nanoclusters (NCs) based on generation 3 (G3) poly(amidoamine) (PAMAM) dendrimers. In brief, G3 dendrimers were crosslinked with 4,4′-dithiodibutryic acid (DA) to generate disulfide-bond-containing dendrimer nanoclusters (DNCs), functionalized with 1,3-propane sultone (1,3-PS) to be zwitterionic, in situ loaded with gold nanoparticles (Au NPs), and finally encapsulated with the drug doxorubicin (DOX). The designed DOX/Au@DNCs-PS possess a favorable colloidal stability with a hydrodynamic size of 249.4 nm, a redox-responsive drug release profile, and enhanced cellular uptake in vitro. We show that DOX/Au@DNCs-PS have a greater DOX penetration and growth inhibition of three-dimensional (3D) tumor spheroids than the single dendrimer counterpart in vitro. Furthermore, the developed Au@DNCs-PS enable a better Au-mediated X-ray attenuation property than the single dendrimer counterpart material. Likely due to the amplified enhanced permeability and retention (EPR) effect, the created Au@DNCs-PS and DOX/Au@DNCs-PS enable better CT imaging and chemotherapeutic effect of a mouse breast tumor model, respectively, than the single dendrimer counterparts. With its proven biocompatibility, the constructed formulation may hold promising potential for development for different cancer nanomedicine applications.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in DNA computing: exploring DNA logic systems and their biomedical applications DNA 计算的进展：探索 DNA 逻辑系统及其生物医学应用

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-06 DOI: 10.1039/d4tb00936c

Yuewei Zhao, Xvelian Li, Yan Zhou, Xiaoting Tian, Yayou Miao, Jiayi Wang, Lin Huang, Fanyu Meng

{"title":"Advancements in DNA computing: exploring DNA logic systems and their biomedical applications","authors":"Yuewei Zhao, Xvelian Li, Yan Zhou, Xiaoting Tian, Yayou Miao, Jiayi Wang, Lin Huang, Fanyu Meng","doi":"10.1039/d4tb00936c","DOIUrl":"https://doi.org/10.1039/d4tb00936c","url":null,"abstract":"DNA computing is regarded as one of the most promising candidates for the next generation of molecular computers, utilizing DNA to execute Boolean logic operations. In recent decades, DNA computing has garnered widespread attention due to its powerful programmable and parallel computing capabilities, demonstrating significant potential in intelligent biological analysis. This review summarizes the latest advancements in DNA logic systems and their biomedical applications. Firstly, it introduces recent DNA logic systems based on various materials such as functional DNA sequences, nanomaterials, and three-dimensional DNA nanostructures. The material innovations driving DNA computing have been summarized, highlighting novel molecular reactions and analytical performance metrics like efficiency, sensitivity, and selectivity. Subsequently, it outlines the biomedical applications of DNA computing-based multi-biomarker analysis in cellular imaging, clinical diagnosis, and disease treatment. Additionally, it discusses the existing challenges and future research directions for the development of DNA computing.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy 基于 BODIPY 的强效光敏剂，用于选择性线粒体功能障碍和有效光动力疗法

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-05 DOI: 10.1039/d4tb01609b

Edward R. H. Walter, Peter Kam-Keung Leung, Lawrence Cho-Cheung Lee, Kenneth Kam-Wing Lo, Nicholas J. Long

{"title":"Potent BODIPY-based photosensitisers for selective mitochondrial dysfunction and effective photodynamic therapy","authors":"Edward R. H. Walter, Peter Kam-Keung Leung, Lawrence Cho-Cheung Lee, Kenneth Kam-Wing Lo, Nicholas J. Long","doi":"10.1039/d4tb01609b","DOIUrl":"https://doi.org/10.1039/d4tb01609b","url":null,"abstract":"The development of new and improved mitochondria-targeting photosensitisers (PSs) for photodynamic therapy (PDT) remains highly desirable, due to the critical role the mitochondria play in maintaining healthy cellular function. Here, we report the design, synthesis, photophysical properties and biological characterisation of a series of di-iodinated BODIPY-based PSs, BODIPY-Mito-I-n, for mitochondria-targeted PDT applications. Six BODIPY-Mito-I-n analogues were synthesised in good yields, with fast reaction times of between 30 and 60 min under mild conditions. The di-iodination of the BODIPY scaffold enabled highly efficient population of the triplet state, leading to high singlet oxygen (1O2) photosensitisation efficiencies (ΦΔ = 0.55–0.65). All BODIPY-Mito-I-n compounds exhibited very high photocytotoxic activity towards HeLa cells, with IC50,light values of between 1.30 and 6.93 nM, due to photoinduced 1O2 generation. Notably, the poly(ethylene glycol) (PEG)-modified BODIPY-Mito-I-6 showed remarkably lower dark cytotoxicity (IC50,dark = 6.68–7.25 μM) than the non-PEGylated analogues BODIPY-Mito-I-1 to BODIPY-Mito-I-5 (IC50,dark = 0.58–1.09 μM), resulting in photocytotoxicity indices up to 2120. Mechanistic studies revealed that BODIPY-Mito-I-6 induced reactive oxygen species overproduction and mitochondrial dysfunction in cells upon irradiation, leading to significant cell death through a combination of apoptosis and necrosis. It is anticipated that our design will contribute to the development of more effective mitochondria-targeting PSs for cancer therapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired triple-layered membranes for periodontal guided bone regeneration applications 应用于牙周引导骨再生的生物启发三层膜

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-05 DOI: 10.1039/d4tb01658k

Yang Yang, Deng-Cheng Yang, Xian-Yan Long, Xiang Liu, Jing-Wen Lu, Zhou-Jing Zhang, Qian-Qian Shi, Yong Zhou, Duo-Hong Zou

{"title":"Bioinspired triple-layered membranes for periodontal guided bone regeneration applications","authors":"Yang Yang, Deng-Cheng Yang, Xian-Yan Long, Xiang Liu, Jing-Wen Lu, Zhou-Jing Zhang, Qian-Qian Shi, Yong Zhou, Duo-Hong Zou","doi":"10.1039/d4tb01658k","DOIUrl":"https://doi.org/10.1039/d4tb01658k","url":null,"abstract":"Barrier membranes have been used for the treatment of alveolar bone loss caused by periodontal diseases or trauma. However, an optimal barrier membrane must satisfy multiple requirements simultaneously, which are challenging to combine into a single material. We herein report the design of a bioinspired membrane consisting of three functional layers. The primary layer is composed of clay nanosheets and chitin, which form a nacre-inspired laminated structure. A calcium phosphate mineral layer is deposited on the inner surface of the nacre-inspired layer, while a poly(lactic acid) layer is coated on the outer surface. The composite membrane integrates good mechanical strength and deformability because of the nacre-inspired structure, facilitating operations during the implant surgery. The mineral layer induces the osteogenic differentiation of bone marrow mesenchymal stem cells and increases the stiffness of the membrane, which is an important factor for the regeneration process. The poly(lactic acid) layer can prevent unwanted mineralization on the outer surface of the membrane in oral environments. Cell experiments reveal that the membrane exhibits good biocompatibility and anti-infiltration capability toward connective tissue/epithelium cells. Furthermore, in vitro analyses show that the membrane does not degrade too fast, allowing enough time for bone regeneration. In vivo experiments prove that the membrane can effectively induce better bone regeneration and higher trabecular bone density in alveolar bone defects. This study demonstrates the potential of this bioinspired triple-layered membrane with hierarchical structures as a promising barrier material for periodontal guided tissue regeneration.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142215166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of lipid vesicle properties on the function of conjugation dependent membrane active peptides 脂质囊泡特性对共轭依赖性膜活性肽功能的影响

IF 6.331 3区医学

Journal of Materials Chemistry B Pub Date : 2024-09-05 DOI: 10.1039/d4tb01107d

Alexandra Iversen, Johanna Utterström, Lalit Pramod Khare, Daniel Aili

{"title":"Influence of lipid vesicle properties on the function of conjugation dependent membrane active peptides","authors":"Alexandra Iversen, Johanna Utterström, Lalit Pramod Khare, Daniel Aili","doi":"10.1039/d4tb01107d","DOIUrl":"https://doi.org/10.1039/d4tb01107d","url":null,"abstract":"Membrane active peptides (MAPs) can provide novel means to trigger the release of liposome encapsulated drugs to improve the efficacy of liposomal drug delivery systems. Design of MAP-based release strategies requires possibilities to carefully tailor the interactions between the peptides and the lipid bilayer. Here we explore the influence of lipid vesicle properties on the function of conjugation-dependent MAPs, specifically focusing on two de novo designed peptides, JR2KC and CKV4. Utilizing liposomes with differences in size, lipid composition, and surface charge, we investigated the mechanisms and abilities of the peptides to induce controlled release of encapsulated cargo. Our findings indicate that liposome size modestly affects the structural changes and function of the peptides, with larger vesicles facilitating a minor increase in drug release efficiency due to higher peptide-to-liposome ratios. Notably, the introduction of negatively charged lipids significantly enhanced the release efficiency, predominantly through electrostatic interactions that favor peptide accumulation at the lipid bilayer interface and subsequent membrane disruption. The incorporation of cholesterol and a mix of saturated and unsaturated lipids was shown to alter the vesicle's phase behavior, thus modulating the membrane activity of the peptides. This was particularly evident in the cholesterol-enriched liposomes, where JR2KC induced lipid phase separation, markedly enhancing cargo release. Our results underscore the critical role of lipid vesicle composition in the design of MAP-based drug delivery systems, suggesting that precise tuning of lipid characteristics can significantly influence their performance.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":null,"pages":null},"PeriodicalIF":6.331,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0