Journal of Materials Chemistry B最新文献

{"title":"Evaluation of peripheral analgesia in a rat incisional pain model using degradable hydrophilic microspheres for sustained delivery of buprenorphine","authors":"Laurent Bédouet, Anne Beilvert, Emeline Servais, Florentina Pascale, Saïda Homayra Ghegediban, Michel Wassef, Julien Namur and Laurence Moine","doi":"10.1039/D5TB01312G","DOIUrl":"10.1039/D5TB01312G","url":null,"abstract":"<p >To target peripheral opioid receptors for postoperative pain relief while minimizing systemic opioid side effects, low doses of buprenorphine hydrochloride (0.8 up to 4.8 mg mL<small>⁻¹</small>) were loaded into prefabricated, hydrophilic, degradable polyethylene glycol-based micropheres (PEG-MS, 50–100 μm) used as a drug delivery platform. By varying the composition of the degradable crosslinker, the degradation rate of PEG-MS, and consequently the drug release duration, could be tuned from 2 days to 2 months. In a pharmacokinetic study in rabbits, the time to the last quantifiable serum concentration (<em>T</em><small>_last</small>) of buprenorphine increased with the degradation time of PEG-MS, reaching 1, 2, 4, and 7 days for microspheres degrading over 2, 6, 12, and 50 days, respectively. PEG-MS demonstrated good biocompatibility, as evidenced by only mild and transient local inflammatory responses during their degradation when implanted in various rabbit tissues, including the dermis, muscle, and subconjunctival space. In a rat incisional pain model, the intraplantar injection of buprenorphine-loaded PEG-MS (degrading over 12 days) at doses of 240 μg and 40 μg increased the paw withdrawal threshold at 24 h by 34% (<em>p</em> &lt; 0.0001) and 20% (<em>p</em> = 0.0466), respectively, compared to drug-free microspheres. Serum concentrations of buprenorphine exceeded the therapeutic threshold, indicating that intraplantar administration resulted in systemic, rather than local, effects. In the context of the opioid crisis, the local administration of a degradable drug delivery system that releases a small amount of buprenorphine in an operative wound for a few days after surgery seems relevant. Nevertheless, while the PEG-MS as buprenorphine delivery system was effective, this preliminary study showed that their local administration resulted in the opioid spreading throughout the body. The future of peripheral analgesia lies in developing opioids with physicochemical properties that prevent them from reaching the brain or being active there.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11855-11869"},"PeriodicalIF":6.1,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb01312g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application and prospects of polysaccharide-based hydrogels in the treatment of intervertebral disc degeneration","authors":"Jun-kuan Shan, Jia-qi Fang, Shu-Hao Liu, Xue-han Jin, Zhi-jie Weng, Li-ping Nan, Jun-jian Liu and Yun Qian","doi":"10.1039/D5TB01191D","DOIUrl":"10.1039/D5TB01191D","url":null,"abstract":"<p >Intervertebral disc degeneration (IVDD) is a primary contributor to chronic low back pain (LBP) and neurological dysfunction. It significantly impairs patients' quality of life. With an aging population and changing lifestyles, the incidence of IVDD has been rising steadily. However, traditional treatments, such as medications, physical therapy, and surgery, primarily alleviate symptoms without fundamentally repairing degenerated discs. Recent advances in tissue engineering and regenerative medicine have led to the development of new therapeutic strategies for IVDD. Among them, hydrogels, which are materials with excellent biocompatibility and tunable properties, show remarkable potential. In particular, polysaccharide-based hydrogels offer unique advantages in IVDD repair thanks to their structural and functional resemblance to native tissues. Their inherent biomimetic properties allow precise replication of the extracellular matrix (ECM) microenvironment in intervertebral discs, providing critical biochemical and biomechanical cues for cell adhesion, proliferation, and differentiation. Additionally, polysaccharide-based hydrogels, with their diverse material bases and modification methods, can flexibly meet the specific demands of various polysaccharide types, providing highly customizable solutions for different stages of the repair process. This paper presents a comprehensive review of recent developments in the application of polysaccharide hydrogels for IVDD therapy.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11525-11539"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iron-doped carbon dots with multi-enzyme activities for rapid determination of phenolic compounds","authors":"Zhanghong Guo, Lin Zhou, Chan Wang and Qijun Song","doi":"10.1039/D5TB01545F","DOIUrl":"10.1039/D5TB01545F","url":null,"abstract":"<p >Multi-enzymic nanozymes have attracted growing attention due to their distinct advantages over single enzyme-like nanozymes, particularly their synergistic effects and cascaded reactions. Herein, iron-doped carbon dots (FeCDs) were prepared by a one-step calcination method using hemin chloride, histidine, and potassium citrate as precursors. The resultant FeCDs exhibit a monodispersed spherical structure with an average particle size of 1.1 nm, where iron acts as a key catalytic active center. Enzyme activity experiments demonstrate that FeCDs exhibit peroxidase-like, catalase-like, and photo-enhanced laccase-like activities. Through the cascade effect of catalase-like and laccase-like activities of FeCDs, the coupling rate of 2,4-dichlorophenol (2,4-DP) and 4-amino-antipyrine (4-AP) was significantly increased. Meanwhile, the peroxidase-like activity can catalyze H<small>₂</small>O<small>₂</small> to form ˙OH, further increasing the oxidation rate of 2,4-DP. Kinetic experiments indicated that the <em>K</em><small>_cat</small>/<em>K</em><small>_m</small> value of the combined action of the three enzyme-like activities was 3.35 times that of the peroxidase-like activity and 4.76 times that of the laccase-like activity, respectively. Based on the multi-enzyme activities of FeCDs, a series of phenolic compounds can be catalytically transformed into chromogenic products within 10 min at room temperature for the rapid determination of these compounds. The results obtained in this work not only provide a reliable strategy for the preparation of carbon-based nanomaterials with multi-enzyme activities, but also expand the application of carbon-based nanomaterials in the field of analysis.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11846-11854"},"PeriodicalIF":6.1,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucose oxidase immobilized on ZIF-7-III: composite formation, optimization and integration in an electrochemical biosensor for selective glucose detection","authors":"Sahar Aghayani, Shahram Tangestaninejad, Norbert Stock, Bastian Achenbach, Mehrnaz Bahadori, Majid Moghadam, S. Fatemeh Nami-Ana, Maryam Sharifi, Valiollah Mirkhani and Iraj Mohammadpoor-Baltork","doi":"10.1039/D5TB01119A","DOIUrl":"10.1039/D5TB01119A","url":null,"abstract":"<p >Coordination polymers (CPs) can be used as supporting materials for enzyme immobilization to overcome limitations arising from mass transfer barriers, active site blocking, and low enzyme loading, as previously demonstrated, employing metal–organic frameworks (MOFs). We report on a new composite containing glucose oxidase (GOD) and ZIF-7-III (Zn(bIm)<small>₂</small>), focusing on three aspects: formation, optimization of catalytic properties, and application. The immobilization of GOD on ZIF-7-III at room temperature was systematically studied by varying the amount of GOD and the reaction time. ZIF-7-III/GOD composites were obtained, as confirmed by Fourier transform infrared (FTIR) spectroscopy and thermogravimetric analysis (TGA). GOD incorporation significantly slows the crystallization of ZIF-7-III. The optimized composite exhibits relative catalytic activity of 98% at maximum enzyme loading, enhanced stability across a broad pH range (3 &lt; pH &lt; 9), and stability at elevated temperatures (up to 80 °C). Storage stability retains 66% activity after 60 days, which is important for possible applications. The use of the composite in an electrochemical biosensor for glucose detection was also demonstrated. Cyclic voltammetry and amperometric measurements were performed, demonstrating high repeatability (RSD &lt;6%) and selectivity against common interferents. A linear response to glucose concentrations in the millimolar range was observed, with a detection limit of 0.01 mmol L<small>⁻¹</small>. Notably, the sensor effectively detected glucose in human plasma samples, indicating its potential for real-world glucose monitoring.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 37","pages":" 11739-11749"},"PeriodicalIF":6.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances and biomedical applications of conductive hydrogels for wound repair","authors":"Yawen Wang, Tong Wu, Xiumei Mo and Yuanfei Wang","doi":"10.1039/D5TB01130B","DOIUrl":"10.1039/D5TB01130B","url":null,"abstract":"<p >The skin, serving as the body's primary line of defense against external elements, is easily damaged, forming acute or chronic wounds. Consequently, wound care has generated significant market demand and attracted considerable interest. Conductive hydrogels, cutting-edge materials that effectively merge the extracellular matrix mimicking properties of hydrogels with the electrochemical properties of conductive materials, have garnered substantial attention in tissue engineering. In addition to the unique mechanical adjustability and bioactive substance transport capabilities of hydrogels, conductive hydrogels provide endogenous electric fields and injury currents to the wound area through electrical stimulation, enhancing cell migration and the development of epithelial layers. Therefore, they possess significant potential for practical application in skin wound repair. This article reviews the applications and recent advancements of conductive hydrogels in wound healing over the past five years, including the types and characteristics of conductive hydrogels and their use in various kinds of wounds, and evaluates the limitations and prospects of conductive hydrogels, offering references and new insights for their future clinical applications.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11148-11165"},"PeriodicalIF":6.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent progress of dermal implants for aged skin rejuvenation: a review","authors":"Qi Wang, Huiyu Yan and Jianxi Xiao","doi":"10.1039/D5TB01263E","DOIUrl":"10.1039/D5TB01263E","url":null,"abstract":"<p >Skin aging is a multifactorial biological process marked by a progressive decline in regenerative capacity, chronic low-grade inflammation, and increased susceptibility to cutaneous disorders, including malignancies. It is driven by both intrinsic factors—such as genetic predisposition and hormonal changes—and extrinsic influences like ultraviolet radiation, environmental pollutants, and unhealthy lifestyle habits. Conventional topical treatments, including moisturizers and sunscreens, offer only transient effects due to limited dermal penetration. In recent years, dermal implants have emerged as promising alternatives for skin rejuvenation, providing enhanced bioavailability, prolonged therapeutic effects, and minimal invasiveness. Among various biomaterials, collagen stands out for its excellent biocompatibility, low immunogenicity, and intrinsic bioactivity. This review systematically summarizes recent progress in implantable strategies for aged skin repair, categorizing materials into five major types: inorganic fillers, synthetic polymers, hyaluronic acid-based, collagen-based, and composite implants. Their structural properties, regenerative mechanisms, and clinical performances are critically compared. Special attention is given to collagen-based implants—hydrogels, fibers, and microspheres—for their roles in modulating inflammation, promoting endogenous collagen synthesis, and facilitating dermal remodeling. The review concludes with an overview of commercialized products and discusses future directions toward precision anti-aging therapies.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11126-11147"},"PeriodicalIF":6.1,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate)","authors":"Joana S. Ferreira, João P. Vareda, A. S. Oliveira, Jéssica S. Barbosa, Francisca Bastos, Patrícia V. Mendonça and A. C. Fonseca","doi":"10.1039/D5TB90123E","DOIUrl":"10.1039/D5TB90123E","url":null,"abstract":"<p >Correction for ‘Polymeric nanocarriers for cancer treatment: the promise of sensitive poly(2-(diisopropylamino)ethyl methacrylate)’ by Joana S. Ferreira <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2025, <strong>13</strong>, 7000–7013, https://doi.org/10.1039/D5TB00268K.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 35","pages":" 11088-11088"},"PeriodicalIF":6.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90123e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144983425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printable PCL-b-P(MMA-co-TMSPMA)/silica hybrids using a PCL RAFT agent","authors":"Athanasios Skandalis, Haffsah Iqbal, Gloria Young, David R. Sory, Jingwen Liu, Peter D. Lee, Sara M. Rankin, Theoni K. Georgiou and Julian R. Jones","doi":"10.1039/D5TB00220F","DOIUrl":"10.1039/D5TB00220F","url":null,"abstract":"<p >Inorganic/organic hybrid biomaterials have the potential to combine the benefits of bioactive glasses, such as bone bonding and osteogenesis, with the ability to withstand cyclic loading. Here, we report on silica/poly(ε-caprolactone-methacrylate) hybrids, using hydroxy monofunctional-PCL as a reversible addition–fragmentation chain transfer (RAFT) agent, for controlled polymerization of PCL-<em>b</em>-P(methyl methacrylate-<em>co</em>-3-(trimethoxysilyl)propyl methacrylate), PCL-<em>b</em>-P(MMA-<em>co</em>-TMSPMA), block copolymers by a combination of ring opening polymerization (ROP) and RAFT polymerization techniques. The new polymer was used for the preparation of hybrids <em>via</em> the sol–gel method, with TMSPMA providing covalent bonds between the silica and PCL-<em>b</em>-P(MMA-<em>co</em>-TMSPMA). The effect of the ratio of CL/silane containing units on the mechanical properties of the hybrids was investigated. The compositions that yielded optimal mechanical properties in bulk form (yield stress 39.3 MPa to 52.9 MPa at a strain of 4–6%) were developed into “inks” for 3D printing porous biodegradable scaffolds for biomedical applications by direct writing. Degradation tests of scaffolds in phosphate buffered saline (PBS) over the course of 180 days showed ∼30% degradation of PCL. The mechanical properties of scaffolds with pore channels of 234–380 μm reduced yield strength to 5.2–7.4 MPa, but yield strain remained at ∼4%. <em>In vitro</em> studies indicated biocompatibility, in terms of exposure of human bone marrow stem cells (hBMCs) to the dissolution products of the scaffolds.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11439-11453"},"PeriodicalIF":6.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00220f?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper–manganese hybrid nanogel for MRI-guided combined photothermal and chemodynamic tumor theranostics","authors":"Yijie Luo, Xiaotong Liang, Kai Wang, Tuohuan Li, Jia Hua, Dalin Wu and Zhong Cao","doi":"10.1039/D5TB01758K","DOIUrl":"10.1039/D5TB01758K","url":null,"abstract":"<p >Bridging tumor diagnosis and therapy remains a major challenge, largely due to the clinical separation of imaging and treatment, compounded by the low relaxivity of conventional MRI contrast agents. To address these limitations, we developed a copper–manganese hybrid nanogel (CMNG) <em>via</em> the <em>in situ</em> incorporation of Mn<small>²⁺</small> ions and CuS nanoparticles within a cross-linked polymeric network. This multifunctional design enables <em>T</em><small>₁</small>-weighted MRI-guided photothermal–chemodynamic therapy. The nanogel matrix significantly enhances the relaxivity of paramagnetic Mn<small>²⁺</small> ions (<em>r</em><small>₁</small> = 10.81 mM<small>⁻¹</small> s<small>⁻¹</small>), surpassing that of clinically approved Gd-based agents. Under 808 nm laser irradiation, CMNG exhibits efficient photothermal conversion (<em>η</em> = 23.29%), which synergistically enhances Cu<small>⁺</small>/Mn<small>²⁺</small>-mediated Fenton-like reactions, resulting in elevated hydroxyl radical (˙OH) production for effective tumor ablation and inhibition of tumor progression. This work presents a rational materials design strategy for integrated theranostic platforms. By combining MRI-guided tracking with potent therapeutic efficacy, the CMNG system offers a promising paradigm for precision cancer theranostics.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 38","pages":" 12101-12110"},"PeriodicalIF":6.1,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial carbon dots integrating multiple mechanisms for selective Gram-positive bacteria elimination and infected wound healing acceleration","authors":"Meng Fang, Liping Lin, Lvjuan Lin, Yaojia Lin, Muyue Zheng, Jinye Zhang, Wei Liu and Qitong Huang","doi":"10.1039/D5TB00754B","DOIUrl":"10.1039/D5TB00754B","url":null,"abstract":"<p >The escalating prevalence of multidrug-resistant Gram-positive bacterial infections demands the development of antimicrobial agents with precise targeting and rapid bactericidal activity. In this study, ultra-small positively-charged carbon dots (PR-CDs) were synthesized through a one-step hydrothermal synthesis of polyethyleneimine and Rhodamine B. The resulting PR-CDs exhibited multiple antibacterial mechanisms: (1) electrostatic attraction to Gram-positive bacterial membranes, (2) cellular internalization enabled by their ultra-small size (2.3 nm), and (3) visible light-activated reactive oxygen species (ROS) generation. PR-CDs have shown selective bactericidal activity against methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) and other Gram-positive pathogens with minimum bactericidal concentrations as low as 19.53 μg mL<small>⁻¹</small> under light irradiation. Mechanistic studies revealed that the positive charges on the surface of PR-CDs facilitated selective binding to teichoic acid-rich Gram-positive cell walls, while their nanoscale dimensions permitted deep penetration into bacterial cells, enhancing oxidative damage through rapid generation of singlet oxygen (<small>¹</small>O<small>₂</small>). Encapsulation of PR-CDs in gellan gum (PR-CDs@GG) hydrogels enabled sustained ROS release and accelerated MRSA-infected wound healing in MRSA-infected mice, achieving 82.51% wound closure within 8 days without systemic toxicity. This work establishes a paradigm for precision antimicrobial design <em>via</em> integrating targeted binding, cellular penetration, and photodynamic activation.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 36","pages":" 11407-11422"},"PeriodicalIF":6.1,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144984148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}