Journal of Materials Chemistry B最新文献_第2页

Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects† 半胱氨酸敏感双峰探针原位监测早期肺纤维化进展及治疗效果的研究。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D5TB00183H

Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai and Weiying Lin

{"title":"Development of cysteine-sensitive bimodal probes for in situ monitoring of early-stage pulmonary fibrosis progression and therapeutic effects†","authors":"Yang Wan, Wenxiu Li, Huayong Zhu, Sixin Ai and Weiying Lin","doi":"10.1039/D5TB00183H","DOIUrl":"10.1039/D5TB00183H","url":null,"abstract":"Pulmonary fibrosis (PF) is a chronic interstitial lung disease characterized by excessive extracellular matrix deposition and lung scarring, leading to impaired lung function, severe respiratory distress, and potentially fatal outcomes. Early diagnosis of PF is crucial for optimizing treatment strategies to improve patient prognosis. However, an activated near-infrared fluorescent (NIRF) and photoacoustic (PA) bimodal probe for non-invasive in situ imaging of PF is still lacking. In this study, we developed a novel cysteine-sensitive NIRF/PA dual-modal probe, MR-Cys, for in situ monitoring of early progression and the therapeutic response in a mouse model of PF. The probe MR-Cys selectively detects cysteine (Cys) levels in vivo, thereby activating both NIRF and PA signals. Using NIRF/PA dual-modal imaging technology, MR-Cys successfully tracked fluctuations in Cys levels within the PF mouse model. After treatment with nintedanib (OFEV), a notable decrease in both PA and NIRF signal intensities was observed in the treated mice, indicating that MR-Cys can be used to assess the therapeutic efficacy for PF. Therefore, MR-Cys not only holds great promise for early detection of pulmonary fibrosis progression, but also offers a precise monitoring tool for the optimization of personalized treatment plans.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5051-5057"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles† 通过表面固定化负载抗生素的多肽多室胶束†增强抗菌保护

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D5TB00246J

Shabnam Tarvirdipour, S. Narjes Abdollahi, Joachim Köser, Maryame Bina, Cora-Ann Schoenenberger and Cornelia G. Palivan

{"title":"Enhanced antimicrobial protection through surface immobilization of antibiotic-loaded peptide multicompartment micelles†","authors":"Shabnam Tarvirdipour, S. Narjes Abdollahi, Joachim Köser, Maryame Bina, Cora-Ann Schoenenberger and Cornelia G. Palivan","doi":"10.1039/D5TB00246J","DOIUrl":"https://doi.org/10.1039/D5TB00246J","url":null,"abstract":"The escalating global threat of antibiotic-resistant bacterial infections, driven by biofilm formation on medical device surfaces, prompts the need for innovative therapeutic strategies. To address this growing challenge, we develop rifampicin-loaded multicompartment micelles (RIF-MCMs) immobilized on surfaces, offering a dual-functional approach to enhance antimicrobial efficacy for localized therapeutic applications. We first optimize the physicochemical properties of RIF-MCMs, and subsequently coat the optimal formulation onto a glass substrate, as confirmed by quartz crystal microbalance and atomic force microscopy. Surface-immobilized RIF-MCMs facilitate sustained antibiotic release in response to biologically relevant temperatures (37 °C and 42 °C). In addition, their heterogeneous distribution enhances the surface's roughness, contributing to the antibacterial activity through passive mechanisms such as hindering bacterial adhesion and biofilm formation. In vitro antimicrobial testing demonstrates that RIF-MCM-modified surfaces achieve a 98% reduction in Staphylococcus aureus viability and a three-order-of-magnitude decrease in colony formation compared to unmodified surfaces. In contrast, RIF-MCMs exhibit minimal cytotoxicity to mammalian cells, making them suitable candidates for medical device coatings. Our dual-function antimicrobial strategy, combining sustained antibiotic release and enhanced surface roughness, presents a promising approach to locally prevent implant-associated infections and biofilm formation.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5365-5379"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb00246j?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair† 高强度骨聚氨酯粘合剂，可快速固化，用于骨组织损伤修复。

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D4TB02390K

Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao and Xuetao Shi

{"title":"High-strength bone polyurethane adhesive with rapid curing for bone tissue injury repair†","authors":"Xuehua Zhao, Jinju Ding, Chengkai Xuan, Jianing Liao and Xuetao Shi","doi":"10.1039/D4TB02390K","DOIUrl":"10.1039/D4TB02390K","url":null,"abstract":"Bone tissue adhesives have advantages such as preventing stress shielding and secondary surgical infections, fixing small bone fragments, easing operations, and enhancing wound adaptability. These methods can be applied for the traumatic repair of comminuted fractures. Currently, commercial tissue adhesives fail to meet the biological safety and mechanical strength requirements of bone tissue adhesives. To address this situation, we developed and screened a rapidly cured high-strength polyurethane bone adhesive. Research has shown that polyurethane bone adhesives have shorter curing times (236 s to 273 s), higher tensile moduli (425.88 MPa to 666.38 MPa), compressive moduli (214.67 MPa to 450.66 MPa), and adhesive strengths (0.92 MPa to 5.86 MPa). It can withstand cyclic stresses ranging from 0.01 MPa to 1 MPa for 1000 cycles. Polyurethane bone adhesive surpasses the inadequate adhesive performance and in vivo repair functionality of existing commercial bone cements, achieving effective repair of bone tissue injuries. Furthermore, we developed an unsaturated ester-modified secondary amine curing agent based on the Michael addition reaction, enabling rapid and safe curing of bone polyurethane adhesives and thereby providing a novel and effective repair solution for bone tissue injuries.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5150-5162"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143813219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative evaluation of accelerated transdermal drug delivery by electroosmosis via frustoconical porous microneedles† 经锥孔微针电渗透加速经皮给药的定量评价

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D4TB02583K

Soichiro Tottori, Sae Ichinose, Fumika Sakai, Reiji Segawa, Taiki Yokoyama, Gaobo Wang and Matsuhiko Nishizawa

{"title":"Quantitative evaluation of accelerated transdermal drug delivery by electroosmosis via frustoconical porous microneedles†","authors":"Soichiro Tottori, Sae Ichinose, Fumika Sakai, Reiji Segawa, Taiki Yokoyama, Gaobo Wang and Matsuhiko Nishizawa","doi":"10.1039/D4TB02583K","DOIUrl":"https://doi.org/10.1039/D4TB02583K","url":null,"abstract":"Electroosmosis-based transdermal drug delivery via frustoconical porous microneedles (F-PMNs) is studied by quantitative fluorescence analysis of the drug models penetrated into excised pig skin. An array of 300 μm height F-PMN made of poly-glycidyl methacrylate is modified by a grafted thin film of anionic poly (2-acrylamido-2-methylpropanesulfonic acid) (PAMPS) or a cationic poly-(3-acrylamidopropyl trimethylammonium) (PAPTAC) to generate electroosmotic flow (EOF) upon application of current through the needles. Owing to the synergy of the EOF-promoted transport and the expansion of the stratum corneum with the frustoconical protrusions, the penetration rates of rhodamine B (479 Da) and FITC-dextran (4 kDa and 10 kDa) are found to be accelerated by more than 10 times. In addition, the F-PMNs modified with PAMPS and PAPTAC show similar delivery rates in opposite directions, enabling the possible dual-mode delivery from both anode and cathode in an integrated iontophoresis device.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5023-5026"},"PeriodicalIF":6.1,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02583k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hapten design, monoclonal antibody preparation, and immunoassay development for rapid detection of naproxen† 半抗原设计、单克隆抗体制备和快速检测萘普生†的免疫分析发展

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-09 DOI: 10.1039/D5TB00330J

Qingqing Liu, Xinxin Xu, Aihong Wu, Chuanlai Xu and Hua Kuang

引用次数: 0

Light-activated spatiotemporal control over nanoreactor permeability† 纳米反应器渗透率的光激活时空控制

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-07 DOI: 10.1039/D4TB02304H

Wouter P. van den Akker, Levena Gascoigne, Alexander B. Cook, Rolf A. T. M. van Benthem, Ilja K. Voets and Jan C. M. van Hest

{"title":"Light-activated spatiotemporal control over nanoreactor permeability†","authors":"Wouter P. van den Akker, Levena Gascoigne, Alexander B. Cook, Rolf A. T. M. van Benthem, Ilja K. Voets and Jan C. M. van Hest","doi":"10.1039/D4TB02304H","DOIUrl":"https://doi.org/10.1039/D4TB02304H","url":null,"abstract":"Interactive materials can be responsive to a variety of stimuli, such as pH, redox, or light. Actuation with light offers excellent spatiotemporal control. Furthermore, it has the advantage that no waste is produced during the light activation process. Herein, we present a strategy to regulate the permeability of pH-responsive nanoreactors using a spiropyran photoacid. Upon light illumination, the photoacid drastically reduced the pH of the environment, which caused the nanoreactor to become permeable. Encapsulation of an enzyme within these nanoreactors therefore allowed for light-induced enzymatic conversion of substrate, and longer irradiation times resulted in an increase in product. Additionally, apart from temporal control, we showed that immobilization of the nanoreactors into a hydrogel matrix also allowed for excellent spatial control. By using a photomask approach, we demonstrated that only in illuminated regions of the hydrogel substrate was converted, due to the local activation of the nanoreactors. Furthermore, this approach could also be applied with higher resolution using confocal microscopy. Irradiating targeted areas with a 480 nm laser line allowed for photoisomerization of the spiropyran, simultaneously inducing permeability. This approach yields high-resolution spatial control over nanoreactor permeability and could potentially be utilized in controlled local synthesis of products or drug release.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 17","pages":" 5171-5180"},"PeriodicalIF":6.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02304h?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Yttrium-90-doped metal–organic frameworks (MOFs) for low-dose rate internal radiation therapy of tumors† 用于肿瘤低剂量率内放射治疗的掺钇金属有机骨架(mof

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-07 DOI: 10.1039/D4TB02809K

Xiaoli Qi, Anzhelika Fedotova, Zhihao Yu, Anna Polyanskaya, Ningfei Shen, Bayirta Egorova, Dmitry Bagrov, Tatiana Slastnikova, Andrey Rosenkranz, Gilles Patriarche, Yurii Nevolin, Anastasia Permyakova, Stanislav Fedotov, Mathilde Lepoitevin, Stepan Kalmykov, Christian Serre and Mikhail Durymanov

{"title":"Yttrium-90-doped metal–organic frameworks (MOFs) for low-dose rate internal radiation therapy of tumors†","authors":"Xiaoli Qi, Anzhelika Fedotova, Zhihao Yu, Anna Polyanskaya, Ningfei Shen, Bayirta Egorova, Dmitry Bagrov, Tatiana Slastnikova, Andrey Rosenkranz, Gilles Patriarche, Yurii Nevolin, Anastasia Permyakova, Stanislav Fedotov, Mathilde Lepoitevin, Stepan Kalmykov, Christian Serre and Mikhail Durymanov","doi":"10.1039/D4TB02809K","DOIUrl":"https://doi.org/10.1039/D4TB02809K","url":null,"abstract":"Brachytherapy, or internal radiation therapy, is a highly effective treatment option for localized tumors. Herein, injectable and biodegradable metal–organic frameworks (MOFs) were engineered to deliver the therapeutic radioisotope yttrium-90 (90Y). Particles of bimetallic MIL-100(Fe,Y) and Y-BTC, doped with 90Y and 88Y, were synthesized in a single step and retained radioyttrium in various buffer solutions. Tumor injectability and radioisotope retention were evaluated using tumor-bearing mice. In vivo analysis and calculations showed that radiolabeled MIL-100(Fe,Y) emitted more than 38% of its radioactivity, while Y-BTC emitted greater than 75% of its radioactivity, for 7 days at the tumor site upon intratumoral injection, without significant yttrium accumulation in off-target tissues. The anticancer effects of MIL-100(Fe,Y,90Y) and 90Y,Y-BTC particles were assessed using 3D multicellular tumor spheroids and a tumor-bearing mouse model, respectively. 90Y-doped MIL-100(Fe,Y) particles penetrated A549 tumor spheroids and caused superior cytotoxic effects compared to non-radioactive particles or 90YCl3, added at the same dose. Brachytherapy with 90Y-doped Y-BTC MOFs induced inhibition of B16F1 melanoma tumor growth and resulted in an increased median survival of 8.5 days compared to 4.5 days in untreated mice. This study shows the feasibility of preparing radioactive 90Y-containing biodegradable non-toxic MOF particles that are advantageous for low-dose rate internal radiotherapy.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5466-5481"},"PeriodicalIF":6.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A biomimetic therapeutic nanovaccine based on dendrimer–drug conjugates coated with metal–phenolic networks for combination therapy of nasopharyngeal carcinoma: an in vitro investigation† 一种基于树状聚合物-药物偶联物包被金属酚网络的仿生治疗性纳米疫苗用于鼻咽癌的联合治疗：体外研究†

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-05 DOI: 10.1039/D5TB00226E

Zhiyun Liu, Xiaochun Deng, Zhiqiang Wang, Yunqi Guo, Meera Moydeen Abdul Hameed, Mohamed EL-Newehy, Jianjun Zhang, Xiangyang Shi and Mingwu Shen

{"title":"A biomimetic therapeutic nanovaccine based on dendrimer–drug conjugates coated with metal–phenolic networks for combination therapy of nasopharyngeal carcinoma: an in vitro investigation†","authors":"Zhiyun Liu, Xiaochun Deng, Zhiqiang Wang, Yunqi Guo, Meera Moydeen Abdul Hameed, Mohamed EL-Newehy, Jianjun Zhang, Xiangyang Shi and Mingwu Shen","doi":"10.1039/D5TB00226E","DOIUrl":"https://doi.org/10.1039/D5TB00226E","url":null,"abstract":"Developing a minimally invasive and potent therapy for nasopharyngeal carcinoma is still challenging. In this study, we report a photothermal nanovaccine based on phenylboronic acid (PBA)-modified poly(amidoamine) dendrimers of generation 5 (G5) attached with indocyanine green (ICG) as a photothermal agent, toyocamycin (Toy) as an endoplasmic reticulum stress (ERS) drug, and Mn2+-coordinated metal–phenolic networks. The developed nanocomplexes are camouflaged with homologous apoptotic cancer cell membranes, leveraging membrane proteins as an antigenic reservoir and incorporating the immune adjuvant cytosine–guanine (CpG) oligonucleotide to obtain the final nanovaccine formulation. The prepared nanovaccine with a size of 72.4 nm displays satisfactory colloidal stability and photothermal conversion efficiency (36.7%), and is capable of targeting cancer cells and inducing apoptosis under laser irradiation through combined ICG-mediated photothermal therapy, Toy-enabled chemotherapy and Mn2+-mediated chemodynamic therapy. Meanwhile, the combined therapeutic effects can elicit immune responses to mature dendritic cells through the immunogenic cell death of cancer cells and the inserted CpG adjuvant/apoptotic cancer cell membranes, and polarize tumor-associated macrophage cells to the antitumor M1 phenotype. The antitumor efficacy of the nanomedicine platform was proven by the test of the penetration and therapeutic inhibition of 3-dimensional tumor spheroids in vitro. The developed functional nanomedicine integrated with different therapeutic modes may be developed as a biomimetic therapeutic nanovaccine for nasopharyngeal carcinoma treatment.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5440-5452"},"PeriodicalIF":6.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Poly(l-lactic acid)/gelatin microfiber membrane loaded with mitomycin C promoting bladder defect repair by anti-fibrosis and antibacterial action 负载丝裂霉素C的聚乳酸/明胶微纤维膜通过抗纤维化和抗菌作用促进膀胱缺损修复

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-05 DOI: 10.1039/D4TB02521K

Lunjie Zhao, Jianyou Xia, Congcong Yang, Jianping Tao, Shanfu Zhang, Wentao Hu, Chen Zhang, Jiuwu Zhang, Qiang Li and Yujie Xu

{"title":"Poly(l-lactic acid)/gelatin microfiber membrane loaded with mitomycin C promoting bladder defect repair by anti-fibrosis and antibacterial action","authors":"Lunjie Zhao, Jianyou Xia, Congcong Yang, Jianping Tao, Shanfu Zhang, Wentao Hu, Chen Zhang, Jiuwu Zhang, Qiang Li and Yujie Xu","doi":"10.1039/D4TB02521K","DOIUrl":"https://doi.org/10.1039/D4TB02521K","url":null,"abstract":"When the bladder is affected by factors such as tumors, tuberculosis, or trauma, its normal structure and function can be severely damaged. At this point, bladder replacement or enlargement surgery may become necessary to restore its structure and improve the patient's quality of life. Traditional bladder reconstruction surgery, specifically ileum augmentation cystoplasty, involves a complex surgical process, along with relatively large operative wounds and possible intestinal obstruction complications. There is also an urgent need for suitable bladder replacement materials. Over the past decade, synthetic bladder scaffolds have emerged as alternatives; however, most fail to simultaneously address the issues of postoperative fibrosis and bacterial infection. To overcome these challenges, we developed an electrospun poly(L-lactic acid)/gelatin (PLLA/GEL) microfiber membrane loaded with mitomycin C (MMC). By optimizing the PLLA/GEL ratio (7 : 3), the membrane exhibited both good rigidity and excellent elasticity. The MMC-loaded fibers demonstrated sustained drug release, effectively inhibiting E. coli and S. aureus in vitro. In rat partial cystectomy models, the PLLA/GEL/MMC group showed a reduction in collagen III deposition through inhibition of the TGF-β/Smad2 pathway, as well as enhanced urothelium regeneration and promotion of angiogenesis. Notably, the membrane maintained cell viability for both urothelial cells and smooth muscle cells over 7 days, confirming its biocompatibility. These findings highlight the promising potential of the PLLA/GEL/MMC microfiber membrane not only as a material for bladder tissue engineering but also as a tool for therapeutic intervention that addresses multiple facets of bladder healing and regeneration.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5427-5439"},"PeriodicalIF":6.1,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacteria-visualizing nano-bactericide with anti-inflammation and wound healing properties for in situ NIR phototherapeutic strategies† 具有抗炎症和伤口愈合特性的细菌可视化纳米杀菌剂用于原位近红外光疗策略

IF 6.1 3区医学

Journal of Materials Chemistry B Pub Date : 2025-04-04 DOI: 10.1039/D4TB02795G

Sen Zhang, Ailin Wu, Ancheng Ouyang, Guixue Lian, Gaoqiang Ma, Lin Wang, Hao Guo, Dongjiao Zhang, Jianzhuang Jiang and Wei Liu

{"title":"Bacteria-visualizing nano-bactericide with anti-inflammation and wound healing properties for in situ NIR phototherapeutic strategies†","authors":"Sen Zhang, Ailin Wu, Ancheng Ouyang, Guixue Lian, Gaoqiang Ma, Lin Wang, Hao Guo, Dongjiao Zhang, Jianzhuang Jiang and Wei Liu","doi":"10.1039/D4TB02795G","DOIUrl":"https://doi.org/10.1039/D4TB02795G","url":null,"abstract":"Anti-infection and wound healing are critical to the survival of patients with skin burns or postoperative infections, and there is an urgent clinical demand for drugs that combine anti-inflammatory and tissue recovery functions, especially new drugs that can overcome the inherent drug resistance of bacteria to conventional antibiotics. In this work, a phototherapeutic bactericide SiPc-CMCS was constructed by covalently grafting silicon phthalocyanine onto natural carboxymethyl chitosan. SiPc-CMCS ingeniously exhibited combined effects of photodynamic and photothermal therapies with wound healing effects for synergistic anti-inflammation and wound recovery, without the constraints of dosage and drug resistance. Two ROS, namely, O2˙− and 1O2, which belong to type I and type II photodynamic pathways, respectively, were observed, and SiPc-CMCS exhibited a photothermal conversion efficiency of η = 26.80%. In vitro and in vivo studies showed effective NIR photodynamic–photothermal antibacterial effect of SiPc-CMCS against both Gram-positive and Gram-negative bacteria. Furthermore, it realized in situ wound healing and fluorescence bacteria visualizing capability. These data prove that SiPc-CMCS is a potential bacteria-readout-guided NIR phototherapeutic bactericide, which is effective against both aerobic and anaerobic bacterial infections, and it possesses excellent wound–healing capability for treating skin burns and postoperative infections.","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 18","pages":" 5403-5416"},"PeriodicalIF":6.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0