Journal of Materials Chemistry B最新文献

{"title":"Dual-functional guanosine-based hydrogel: high-efficiency protection in radiation-induced oral mucositis†","authors":"Zihan Ding, Xiaopei Hu, Wenhui Liang, Shuhao Zheng, Xiaobo Luo and Hang Zhao","doi":"10.1039/D4TB02380C","DOIUrl":"10.1039/D4TB02380C","url":null,"abstract":"<p >Radiation-induced oral mucositis (RIOM) is the most common adverse effect experienced by cancer patients following radiotherapy; however, effective clinical treatments remain insufficiently recognized. In this study, a guanosine-polyvinyl alcohol (G-PVA) supramolecular hydrogel was developed using a one-pot synthesis method. The G-PVA hydrogel demonstrated remarkable wet adhesion properties measuring 74.16 kPa (±3.53 kPa), biocompatibility and shape adaptability, making it suitable for the dynamic conditions of the oral cavity. Under radiation exposure, the G-PVA hydrogel not only mitigated oxidative stress but also provided effective protection to cells against direct damage, as shown by the decrease in the number of γ-H2AX foci from 79.81% (±1.33%) to 5.70% (±0.88%) and 17.12% (±3.44%), respectively. <em>In vivo</em> investigations further validated that the G-PVA hydrogel significantly reduced RIOM, with a decrease in the relative ulcerative area by 52.23% in comparison to the IR group. This dual-functional supramolecular hydrogel may represent a promising new clinical strategy for the prevention of RIOM in the future.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3039-3048"},"PeriodicalIF":6.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy","authors":"Kexin Fan, Ludan Zhang, Qinqiu Zhong, Yanhe Xiang, Bowei Xu and Yuguang Wang","doi":"10.1039/D5TB90022K","DOIUrl":"10.1039/D5TB90022K","url":null,"abstract":"<p >Correction for ‘Acceptor–donor–acceptor-type molecules with large electrostatic potential difference for effective NIR photothermal therapy’ by Kexin Fan <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2024, <strong>12</strong>, 5140–5149, https://doi.org/10.1039/D4TB00187G.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2560-2560"},"PeriodicalIF":6.1,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90022k?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bipyramidal gold nanoparticles-assisted plasmonic photothermal therapy for ocular applications†","authors":"David Alba-Molina, Manuel Cano, Mario Blanco-Blanco, Laura Ortega-Llamas, Yolanda Jiménez-Gómez, Ana Gonzalez-Lopez, Mayelin Perez-Perdomo, Luis Camacho, Juan J. Giner-Casares and Miguel Gonzalez-Andrades","doi":"10.1039/D4TB02688H","DOIUrl":"10.1039/D4TB02688H","url":null,"abstract":"<p >Gold nanoparticles (AuNPs) play a key role in the field of nanomedicine due to their fascinating plasmonic properties as well as their great biocompatibility. An intriguing application is the use of plasmonic photothermal therapy (PPTT) mediated by anisotropic AuNPs irradiated with a near-infrared (NIR) laser for treating ocular diseases in ophthalmology. For this purpose, bipyramidal-shaped AuNPs (BipyAu), which were surface-functionalized with three different organic ligands (citrate, polystyrene sulphonate (PSS), and cetyltrimethylammonium bromide (CTAB)), were synthesized. The long-term storage stability was assured, in terms of minimal variation in aspect ratio and localized surface plasmon resonance. Better performance was achieved with BipyAu@citrate and BipyAu@PSS NPs. PPTT experiments mediated with the synthesized BipyAu NPs demonstrated that BipyAu@citrate provided the highest value of temperature increase (40 °C at 2.0 W cm<small>⁻²</small>) after 15 min of 808 nm NIR laser irradiation. The potential future clinical application in ophthalmology was assessed by <em>in vitro</em> cytotoxicity analysis, confirming that BipyAu@citrate NPs were biocompatible for the three major corneal cell types. Furthermore, <em>ex vivo</em> analysis was performed by treating pig corneas with BipyAu@citrate NPs (0.18 μg Au) and subsequent NIR laser irradiation at 808 nm for 15 min, showing distortions in the collagen type I fibrils at the ultrastructural level and promoting the flattening of the corneal surface after treatment, without inducing cell cytotoxicity. This work suggests that a precise control of the fibril distortions can be provoked by PPTT mediated with BipyAu@citrate in the NIR region, paving the way for nanomedicine to correct common deficiencies in corneal diseases.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3000-3010"},"PeriodicalIF":6.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging","authors":"Kazuki Inoue, Ryosuke Kawakami, Masamoto Murakami, Taku Nakayama, Shinkuro Yamamoto, Keiji Inoue, Teruko Tsuda, Koji Sayama, Takeshi Imamura, Daisuke Kaneno, Shingo Hadano, Shigeru Watanabe and Yosuke Niko","doi":"10.1039/D5TB90024G","DOIUrl":"10.1039/D5TB90024G","url":null,"abstract":"<p >Correction for ‘Synthesis and photophysical properties of a new push–pull pyrene dye with green-to-far-red emission and its application to human cellular and skin tissue imaging’ by Kazuki Inoue <em>et al.</em>, <em>J. Mater. Chem. B</em>, 2022, <strong>10</strong>, 1641–1649, https://doi.org/10.1039/D1TB02728J.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 7","pages":" 2559-2559"},"PeriodicalIF":6.1,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d5tb90024g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifunctional metal–phenolic nanoparticles with antibacterial and anti-inflammatory effects for osteomyelitis management","authors":"Qinsheng Hu, Chengcheng Wu, Ling Wang, Dan Cao, Junchao Wang, Yangrui Du, Miao Liu and Kaijun Li","doi":"10.1039/D4TB02649G","DOIUrl":"10.1039/D4TB02649G","url":null,"abstract":"<p >Osteomyelitis is a serious inflammatory disease mostly caused by bacterial infections. It is necessary to simultaneously eradicate bacterial cells and inhibit inflammation in treating osteomyelitis. Herein, we design an innovative zinc ion (Zn<small>²⁺</small>)-based nano delivery system for the management of osteomyelitis. Taking advantage of the coordination self-assembly of Zn<small>²⁺</small>, quercetin (QU), and ε-poly-<small>L</small>-lysine (EPL), Zn<small>²⁺</small>-containing nanoparticles (denoted as ZQE NPs) are prepared. ZQE NPs are spherical nanoparticles with amorphous structures. They are stable in the physiological neutral environment but can be dissociated in an acidic microenvironment of infection sites. Since Zn<small>²⁺</small> is encapsulated into ZQE NPs by coordination interaction, the deactivation of Zn<small>²⁺</small> by proteins can be effectively avoided. Therefore, ZQE NPs can maintain excellent bactericidal activity in a protein-rich environment, while dissociative Zn<small>²⁺</small> doesn’t exhibit obvious bactericidal ability. Meanwhile, ZQE NPs are highly effective at scavenging intracellular reactive oxygen species (ROS) and inhibiting pro-inflammatory cytokines, due to the strong anti-inflammatory effects of QU and Zn<small>²⁺</small>. The <em>in vivo</em> therapeutic efficacy of ZQE NPs is assessed using a rat model of methicillin-resistant <em>Staphylococcus aureus</em> (MRSA)-induced osteomyelitis. Results demonstrate that ZQE NPs effectively eradicate bacterial cells and reduce inflammation <em>in vivo</em>, thereby promoting osteogenesis and recovery of osteomyelitis.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3067-3079"},"PeriodicalIF":6.1,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ice templating water-stable macroporous polysaccharide hydrogels to mimic plant stems†","authors":"Katsuya Komiyama, Maya Allard, Corentin Eschenbrenner, Clémence Sicard, Ahmed Hamraoui and Francisco M. Fernandes","doi":"10.1039/D4TB02204A","DOIUrl":"10.1039/D4TB02204A","url":null,"abstract":"<p >Water-stable macroporous hydrogels, inspired by the structural and chemical characteristics of plant stems, are expected to open a wide range of possibilities in soft materials for passive liquid transport. However, obtaining efficient materials for these applications still poses a major challenge due to the complexity of shaping hydrogels at the relevant scale-length. Here, water-stable macroporous hydrogels were fabricated using alginate and TEMPO-oxidized cellulose <em>via</em> a new approach involving ice templating and topotactic ion-crosslinking with Ca<small>²⁺</small>. This approach fully avoids the energy-intensive lyophilization process and results in composite hydrogels with pore sizes akin to those found in celery xylem, a model we chose for plant stems. Importantly, the pore size could be tailored by adjusting both the ice-growth velocities and the ratios of alginate to oxidized cellulose. The resulting hydrogels displayed remarkable water stability along with viscoelastic properties and wettability that depend on the alginate and oxidized cellulose ratios. Mechanical properties, such as compression stress and toughness, consistently increased with higher alginate contents. In addition, liquid transport measurements on crosslinked hydrogels with varying compositions and ice growth velocities revealed rising speeds comparable to those observed in celery, confirming the ability of polysaccharide-based hydrogels obtained by ice templating and topotactic crosslinking as relevant materials to mimic the function of plant stems. Due to their intrinsic biocompatibility, the materials presented here offer significant potential for developing soft liquid transport systems suited for biological settings, with promising applications in both environmental and bioengineering fields.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3173-3185"},"PeriodicalIF":6.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of poly(ester amide)-based materials for 3D printing of tissue engineering scaffolds†","authors":"Patrícia dos Santos, Beatriz Alves, Sara Inocêncio, Pedro Nunes, Stephen M. Richardson, Antonio Gloria, Arménio Serra, Ana Clotilde Fonseca and Marco Domingos","doi":"10.1039/D4TB02220C","DOIUrl":"10.1039/D4TB02220C","url":null,"abstract":"<p >The fabrication of three-dimensional (3D) scaffolds with imprinted physical, chemical and topographical cues is instrumental in tissue engineering strategies to instruct cell function and guide the regeneration of tissues. α-Amino acids based poly(ester amide)s (AAA-PEAs), combining the biocompatibility and biodegradability of polyesters with the superior mechanical properties of polyamides, have emerged as promising scaffolding materials. However, their processing <em>via</em> extrusion-based 3D printing remains challenging due to the lack of polymeric structures with suitable molecular weight and thermal stability. Here, we develop a new library of high molecular weight AAA-PEAs based on <small>L</small>-alanine (PEA-ala), <small>L</small>-alanine/glycine (PEA-ala–gly (75 : 25)) and <small>L</small>-alanine/glycine/jeffamine (PEA-ala–gly–jeff (50 : 25 : 25)) and investigate their performance as polymeric materials for 3D printing against commercially available poly(ε-caprolactone) (PCL). Thermogravimetric analysis reveals the stability of AAA-PEAs at high temperatures, enabling their processing <em>via</em> melt-extrusion printing. Despite differences in complex viscosity between PCL and AAA-PEAs, highlighted by oscillatory rheology measurements, the printability of AAA-PEAs does not seem to be compromised, resulting in 3D scaffolds with good shape-fidelity. Additional physicochemical characterisation of synthesised materials also confirm the possibility of fabricating two-dimensional (2D) films and 3D scaffolds with different mechanical properties, wettability and degradation profiles, depending on the AAA-PEA used. Biological tests carried out <em>in vitro</em> confirm the ability of synthesised materials to support the adhesion and function of metabolically active human bone marrow derived mesenchymal stem cells (hBM-MSCs). The newly synthesised AAA-PEAs expand the range of processable materials <em>via</em> melt-extrusion and contribute to the fabrication of scaffolds with tuneable physicochemical properties for improved tissue regeneration.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 3049-3066"},"PeriodicalIF":6.1,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb02220c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature and light dual-responsive hydrogels for anti-inflammation and wound repair monitoring†","authors":"Ji Jiang, Yuan Tian, Xiaoyang Wu, Mingze Zeng, Chengheng Wu, Dan Wei, Hongrong Luo, Jing Sun, Jie Ding and Hongsong Fan","doi":"10.1039/D4TB02555E","DOIUrl":"10.1039/D4TB02555E","url":null,"abstract":"<p >Wound healing is a complex and dynamic biological process that requires meticulous management to ensure optimal outcomes. Traditional wound dressings, such as gauze and bandages, although commonly used, often fall short in their frequent need for replacement, lack of real-time monitoring and absence of anti-inflammatory and antibacterial properties, which can lead to increased risk of infection and delayed healing. Here, we address these limitations by introducing an innovative hydrogel dressing, named PHDNN6, to combine wireless Bluetooth temperature monitoring and light-triggered nitric oxide (NO) release to enhance wound healing and management. The PHDNN6 hydrogel is based on a poly(<em>N</em>-isopropylacrylamide) (PNIPAM) matrix, integrated with methacrylated and dopamine-grafted hyaluronic acid (HA–MA–DA), which allows the dressing to be highly responsive to changes in wound temperature, enabling continuous and real-time monitoring of the wound microenvironment wirelessly. Besides, PHDNN6 is embedded with photothermal polydopamine nanoparticles (PDA NPs) that are loaded with a NO donor, <em>N</em>,<em>N</em>′-di-<em>sec</em>-butyl-<em>N</em>,<em>N</em>′-dinitroso-1,4-phenylenediamine (BNN6). When exposed to near-infrared (NIR) laser irradiation, these PDA@BNN6 nanoparticles release NO to provide potent antibacterial and anti-inflammatory effects. The integration of continuous wireless temperature monitoring with NO release within a single hydrogel dressing represents a significant advancement in clinical wound care. This dual-functional platform not only provides real-time diagnostic capabilities but also offers therapeutic interventions to manage wound infections and promote tissue regeneration. Our research highlights the potential of PHDNN6 to revolutionize wound management by offering a comprehensive solution that addresses both the diagnostic and therapeutic needs in wound healing.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2855-2870"},"PeriodicalIF":6.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterials and clinical SERS technology: broad applications in disease diagnosis","authors":"Ifeanyichukwu Michael Onyemaobi, Yujiao Xie, Jiahao Zhang, Lei Xu, Lingchao Xiang, Jie Lin and Aiguo Wu","doi":"10.1039/D4TB02525C","DOIUrl":"10.1039/D4TB02525C","url":null,"abstract":"<p >The critical need for rapid cancer diagnosis and related illnesses is growing alongside the current healthcare challenges, unfavorable prognosis, and constraints in diagnostic timing. As a result, emphasis on surface-enhanced Raman spectroscopy (SERS) diagnostic methods, including both label-free and labelled approaches, holds significant promise in fields such as analytical chemistry, biomedical science, and physics, due to the user-friendly nature of SERS. Over time, the SERS detection sensitivity and specificity with nanostructured materials for SERS applications (NMs-SERS) in different media have been remarkable. An investigation into electronic dynamics and interactions has revealed a seemingly fair result regarding the complementary effects of electromagnetic (EM) and chemical enhancements (CM), underscoring the operational principles of SERS. Nevertheless, the focus on translational SERS applications, especially beyond preliminary proof-of-concept research, remains limited. This review focuses on the advancements made in clinical SERS diagnostics and the essential role of NMs-SERS, ranging from plasmonic to non-plasmonic materials and other related advancements. Furthermore, it outlines the significant achievements of biomedical SERS in tumor diagnosis, particularly in identifying circulating tumor cells (CTCs), alongside a clear focus on NMs-SERS characteristics such as surface charge, shape, size, detection sensitivity, specificity, signal reproducibility, and recyclability. Finally, it underscores the use of microfluidic chips within the labelled SERS strategy for isolating CTCs, the concept of Ramanomics, and the integration of artificial intelligence (AI) to strengthen SERS data analysis. We hope that this review will help guide and expedite the potential for precise SERS diagnosis of key chronic diseases.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 9","pages":" 2890-2911"},"PeriodicalIF":6.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, development and performance of a Fe–Mn–Si–Cu alloy for bioabsorbable medical implants","authors":"J. N. Lemke, J. Fiocchi, C. A. Biffi, A. Tuissi, F. Copes, C. Paternoster, D. Mantovani and A. Coda","doi":"10.1039/D4TB01635A","DOIUrl":"10.1039/D4TB01635A","url":null,"abstract":"<p >Bioabsorbable metallic alloys constitute a very challenging and innovative field, mainly aimed to develop the next generation of temporary medical implants. Degradation data, biological <em>in vitro</em> and <em>in vivo</em> tests are of major importance in particular for complex alloys, in which the individual element additions could enhance material performance and add functionalities. In this study, a novel Fe–Mn–Si–Cu alloy was carefully designed for vascular and blood-contact applications, and its microstructure, mechanical behavior, degradation behavior and biological performances were investigated accordingly. In previous studies, Mn and Si were found to be suitable elements to effectively enhance mechanical properties and accelerate corrosion rate in simulated body fluid. Cu was added for further grain refinement by the formation of small Cu-rich particles, potentially impacting mechanical properties and degradation behavior. In addition, the feasibility of inducing antibacterial effects in a Fe–Mn–Si–Cu alloy with low Cu content was investigated. The alloy was prepared firstly on a small scale by vacuum arc remelting, then on a larger scale by vacuum induction melting and converted into sheets by conventional thermomechanical processing techniques. Heat treatments were explored to find optimal microstructure conditions. The results confirm promising mechanical, degradation and biological performance in testing the material in <em>in vitro</em> conditions, showing that the degradation products are neither systematically cytotoxic nor have any hemotoxic effects. On the other hand, the expected antibacterial effects could not be confirmed.</p>","PeriodicalId":83,"journal":{"name":"Journal of Materials Chemistry B","volume":" 8","pages":" 2737-2752"},"PeriodicalIF":6.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/tb/d4tb01635a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}