Biomacromolecules最新文献_第2页

Self-Cross-Linked Collagen Sponge from the Alosa sapidissima Scale for Hemostasis and Wound Healing Applications.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-16 DOI: 10.1021/acs.biomac.4c01211

Xiaoyun Li, Yue Xu, Zijun Zhou, Mingliang Tang, Jinjia Cui, Wenjing Han, Jingyi Li, Jing Dai, Xiaoyi Ren, Huihui Jiang, Yanzhen Yu, Qinghua Liu, Hongmei Tang, Miao Xiao

{"title":"Self-Cross-Linked Collagen Sponge from the Alosa sapidissima Scale for Hemostasis and Wound Healing Applications.","authors":"Xiaoyun Li, Yue Xu, Zijun Zhou, Mingliang Tang, Jinjia Cui, Wenjing Han, Jingyi Li, Jing Dai, Xiaoyi Ren, Huihui Jiang, Yanzhen Yu, Qinghua Liu, Hongmei Tang, Miao Xiao","doi":"10.1021/acs.biomac.4c01211","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01211","url":null,"abstract":"Type I collagen, a crucial component maintaining the structural integrity and physiological function of various tissues, is widely regarded as one of the most suitable biomaterials for healthcare applications. In this study, shad scales, used for treating ulcers, scalds, and burns in traditional Chinese medicine, were exploited for type I collagen extraction. After self-assembly into hydrogels, the extracted collagen was subsequently freeze-dried to form collagen sponges. The collagen sponge promoted rapid hemostasis, neovascularization, and immune regulation. Additionally, it accelerated the formation of granulation tissue, re-epithelialization, and collagen remodeling at the wound site in full-thickness skin wound rat models. Consequently, the shad scale collagen sponge holds great promise for the treatment of chronic wounds and skin regeneration. Notably, the shad was sourced from sustainably recirculating aquaculture systems (RAS) farms that adhere to the Traceable Management of Animal Products Safety, ensuring that the derived collagen possesses potential in the medical apparatus market.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Performance Triple-Network Hydrogels Derived from Chrome Leather Scraps: Ultrahigh Compressive Strength, Adhesion, and Self-Recovery.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-16 DOI: 10.1021/acs.biomac.4c01538

Jingjing Ren, Bin Lyu, Dangge Gao, Yatong Fu, Jianzhong Ma

{"title":"High-Performance Triple-Network Hydrogels Derived from Chrome Leather Scraps: Ultrahigh Compressive Strength, Adhesion, and Self-Recovery.","authors":"Jingjing Ren, Bin Lyu, Dangge Gao, Yatong Fu, Jianzhong Ma","doi":"10.1021/acs.biomac.4c01538","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01538","url":null,"abstract":"The development of engineered hydrogels with high strength, self-recovery, and adhesion is essential for applications requiring resistance to large deformations and cyclic loading. Herein, a triple-network (TN) hydrogel with ultrahigh compressive strength, strong adhesion, and good self-recovery was constructed by using tannic acid-modified chrome leather scrap hydrolysate as the first network, polyacrylamide as the second network, and poly-2-propenamide-2-methylpropanesulfonic acid as the third network. The ultrahigh (70 MPa compressive strength and 95% compression deformation) TN hydrogels were effectively created, which is attributed to the synergy of the three networks. The TN hydrogels display adhesion (adhesion strength > 20 kPa) ascribed to the introduction of phenolic hydroxyl groups in tannic acid. Intriguingly, the TN hydrogels exhibit excellent self-recovery performance (93.6% dissipated energy recovery at 70 °C) and shape memory performance (restored to the original shape in 20 s). These properties are essential for the development of high-performance hydrogels and promote the resource utilization of leather waste.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142833211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials. 作为可持续细胞相容性纳米生物材料的丝胶/壳聚糖超分子多层薄膜

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-16 DOI: 10.1021/acs.biomac.4c01146

Miguel Rosas, Cristiana F V Sousa, Ana Pereira, Adérito J R Amaral, Tamagno Pesqueira, Sónia G Patrício, Sara Fateixa, Helena I S Nogueira, João F Mano, Ana L Oliveira, João Borges

{"title":"Silk Sericin/Chitosan Supramolecular Multilayered Thin Films as Sustainable Cytocompatible Nanobiomaterials.","authors":"Miguel Rosas, Cristiana F V Sousa, Ana Pereira, Adérito J R Amaral, Tamagno Pesqueira, Sónia G Patrício, Sara Fateixa, Helena I S Nogueira, João F Mano, Ana L Oliveira, João Borges","doi":"10.1021/acs.biomac.4c01146","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01146","url":null,"abstract":"Silk sericin (SS) has been widely discarded as a waste by the silk textile industry during the degumming process to obtain fibroin. However, in the past decade, an in-depth understanding of its properties and functions turned it into a high added-value biomaterial for biomedical applications. Herein, we report the molecular design and development of sustainable supramolecular multilayered nanobiomaterials encompassing SS and oppositely charged chitosan (CHT) through a combination of self-assembly and electrostatically driven layer-by-layer (LbL) assembly technology. The successful buildup of SS/CHT multilayered nanobiomaterials was demonstrated by the quartz crystal microbalance with dissipation monitoring and attenuated total reflectance-Fourier transform infrared spectroscopy, and the nanofilms' wettable properties and nanofibrillar-like topography were shown by water contact angle, atomic force microscopy, and scanning electron microscopy. In vitro assays demonstrated the cytocompatibility of the LbL nanofilms toward human primary dermal fibroblasts, holding great promise as biofunctional nanocoatings for drug/therapeutics/cell delivery, tissue engineering, and regenerative medicine.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mimicking the Bone Extracellular Matrix through a Calcium Phosphate-Containing Thiol-Ene Cross-Linked Gelatin Composite. 通过含磷酸钙的硫醇-炔交联明胶复合材料模拟骨细胞外基质

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-16 DOI: 10.1021/acs.biomac.4c01182

Laurens Parmentier, Sophie D'Haese, Louis Van der Meeren, Anna Szabó, Andre G Skirtach, Ruslan I Dmitriev, Janis Locs, Sandra Van Vlierberghe

{"title":"Mimicking the Bone Extracellular Matrix through a Calcium Phosphate-Containing Thiol-Ene Cross-Linked Gelatin Composite.","authors":"Laurens Parmentier, Sophie D'Haese, Louis Van der Meeren, Anna Szabó, Andre G Skirtach, Ruslan I Dmitriev, Janis Locs, Sandra Van Vlierberghe","doi":"10.1021/acs.biomac.4c01182","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01182","url":null,"abstract":"Hydroxyapatite (HAP) and amorphous calcium phosphate (ACP) nanoparticles were incorporated into a thiol-ene clickable gelatin network to elucidate to what extent osteogenic differentiation of human dental pulp- and adipose-derived stem cells (HDPSCs/HASCs) could be further boosted. ACP nanoparticles increased the specific surface area by 23% and reduced the density by 13% while maintaining a comparable particle size (ACP: 25 ± 3 nm; HAP: 27 ± 3 nm). Overall, the incorporation of ceramic nanoparticles did not significantly alter the mechanical properties of the ceramic-containing composites compared to the unsubstituted thiol-ene network. ACP nanoparticles at high concentrations promoted a 21-day osteogenic response in HASCs (72.09 ± 20.20 ng Ca2+/ng DNA) comparable to HDPSCs, with the latter showing high calcium production irrespective of the ceramic content (78.45 ± 10.87 ng Ca2+/ng DNA), suggesting that the provided cues must be optimized according to the investigated cell type toward a cell-interactive coating application stimulating osteogenesis.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of an Injectable Thermosensitive Hydrogel Drug Delivery System for Degenerated Intervertebral Disc Regeneration.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-13 DOI: 10.1021/acs.biomac.4c00965

Yuheng Liu, Chuan Guo, Yu Wang, Qing-Quan Kong

引用次数: 0

Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-13 DOI: 10.1021/acs.biomac.4c01463

Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen

{"title":"Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics.","authors":"Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen","doi":"10.1021/acs.biomac.4c01463","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01463","url":null,"abstract":"Cellulose-nanomaterial-derived films are promising platforms for engineering advanced substrates for printed electronics. However, they are highly susceptible to water and humidity, which limit their wide application. To overcome these drawbacks, cellulose nanoworms (distinct hydrophobized cellulose nanomaterials) were introduced in this study as sustainable coatings to enhance the water resistance of cellulose nanofiber (CNF) films. Alcogels of nanoworms, produced via ethanol-induced swelling and ultrasonication of a cellulose pulp esterified in a deep eutectic solvent, form a dense and transparent coating on the CNF films, significantly inhibiting their water absorption and improving their surface smoothness. Furthermore, the resulting coated CNF films exhibited enhanced hydrophobicity with improved wet mechanical properties and lower water vapor permeability. In addition, the results of the ink-printing tests revealed that the coated films partially or completely inhibited ink removal. Thus, this study demonstrated that cellulose nanoworm coatings provide a promising approach to overcome the moisture sensitivity of CNF films.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lysosomal Trafficking and Degradation of Extracellular Proteins via Multivalent Small Molecule Ligand Display on Dextran Scaffolds. 通过在葡聚糖支架上显示多价小分子配体，实现溶酶体对细胞外蛋白质的转运和降解。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-13 DOI: 10.1021/acs.biomac.4c01603

Benoit Louage, Demi Defreyne, Heleen Lauwers, Jamie De Baere, Annemiek Uvyn, Haixia Peng, Yong Chen, Bruno G De Geest

{"title":"Lysosomal Trafficking and Degradation of Extracellular Proteins via Multivalent Small Molecule Ligand Display on Dextran Scaffolds.","authors":"Benoit Louage, Demi Defreyne, Heleen Lauwers, Jamie De Baere, Annemiek Uvyn, Haixia Peng, Yong Chen, Bruno G De Geest","doi":"10.1021/acs.biomac.4c01603","DOIUrl":"10.1021/acs.biomac.4c01603","url":null,"abstract":"Targeted protein degradation (TPD) marks a shift in drug development from conventional inhibition to the complete removal of pathological proteins. Traditional TPD technologies target intracellular proteins of interest (POIs) for degradation but are ineffective against extracellular cell surface and soluble proteins, a significant portion of the human proteome. Recent advances involve the formation of ternary complexes between a POI and a cell surface lysosomal trafficking receptor, directing POIs to lysosomes for degradation. We report on DEXtran TRAfficking Chimeras (DEXTRACs) comprising multiple copies of synthetic small molecule ligands for a model POI and the cation-independent mannose-6-phosphate receptor (CI-M6PR) lysosomal trafficking receptor. These ligands are arranged along the dextran backbones. We demonstrate that DEXTRACs leverage multivalency with their efficacy dependent on the dextran chain length and ligand density to form high-avidity ternary complexes. Our in vitro studies confirmed that DEXTRACs traffic the target POI to lysosomes and facilitate its degradation.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioresponsive Polymeric Nanoparticles: From Design, Targeted Therapy to Cancer Immunotherapy.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-12 DOI: 10.1021/acs.biomac.4c01257

Huanli Sun, Zhiyuan Zhong

{"title":"Bioresponsive Polymeric Nanoparticles: From Design, Targeted Therapy to Cancer Immunotherapy.","authors":"Huanli Sun, Zhiyuan Zhong","doi":"10.1021/acs.biomac.4c01257","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01257","url":null,"abstract":"Bioresponsive polymeric nanoparticles (NPs) that are capable of delivering and releasing therapeutics and biotherapeutics to target sites have attracted vivid interest in cancer therapy and immunotherapy. In contrast to enthusiastic evolution in the academic world, the clinical translation of these smart systems is scarce, partly due to concerns about safety, stability, complexity, and scalability. The moderate targetability, responsivity, and benefits are other concerns. In the past 17 years, we have devoted ourselves to exploring elegant strategies to address the above basic and translational problems by introducing diverse functional groups and/or targeting ligands to safe biomedical materials, such as biodegradable polymers and water-soluble polymers. This minimal modification is critical for further clinical translation. We have tailor-made various bioresponsive NPs including shell-sheddable and/or acid-sensitive biodegradable NPs, disulfide-cross-linked biodegradable micelles and polymersomes, and blood-brain barrier (BBB)-permeable NPs, to target different tumors. This perspective provides an overview of our work path toward targeted nanomedicines and personalized vaccines, which might inspire clinical translation and future research on cancer therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating the Properties of Hybrid Nanocellulose Films.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-12 DOI: 10.1021/acs.biomac.4c01034

Naghmeh Nasiri, Hans Estrella Cainglet, Jay R Black, Gil Garnier, Warren Batchelor

引用次数: 0

Diving into RNAi Therapy: An Inhalable Formulation Based on Lipid-Polymer Hybrid Systems for Pulmonary Delivery of siRNA.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-12 DOI: 10.1021/acs.biomac.4c00387

Marta Cabibbo, Cinzia Scialabba, Emanuela F Craparo, Simone P Carneiro, Olivia M Merkel, Gennara Cavallaro

{"title":"Diving into RNAi Therapy: An Inhalable Formulation Based on Lipid-Polymer Hybrid Systems for Pulmonary Delivery of siRNA.","authors":"Marta Cabibbo, Cinzia Scialabba, Emanuela F Craparo, Simone P Carneiro, Olivia M Merkel, Gennara Cavallaro","doi":"10.1021/acs.biomac.4c00387","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00387","url":null,"abstract":"Here, a pulmonary formulation based on lipid-polymer hybrid nanoparticles carrying small interfering RNA (siRNA) was developed to realize a RNA interference-based therapy to treat respiratory diseases. Toward this aim, a new copolymer was synthesized, by functionalization of the α,β-poly(N-2-hydroxyethyl)-d,l-aspartamide with 35 mol % of 1,2-bis(3-aminopropylamino)ethane, 0.4 mol % of fluorescent dye, and 4.5 mol % of poly(lactic-co-glycolic acid). This was used to encapsulate siRNA targeting the green fluorescent protein (siGFP), within a lipid shell made from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and 1,2-distearoyl-sn-glycero-phosphoethanolamine-N-(polyethylene glycol)2000. siGFP-loaded lipid-polymer hybrid nanoparticles (LPHFNPs@siGFP) exhibited colloidal size (∼164 nm), positive ζ potential, high siRNA encapsulation efficiency (∼99%), and a core-shell morphology. They showed high cellular uptake and a gene silencing efficiency of ∼50% in human lung cancer cells expressing GFP. To address aerodynamic challenges, LPHFNPs@siGFP were spray-dried with trehalose, yielding spherical particles (∼3 μm) with 80% siRNA encapsulation efficiency, excellent aerosolization properties, and a gene silencing efficiency comparable to the fresh LPHFNPs@siGFP sample.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0