Biomacromolecules最新文献_第2页

Multifunctional and UV Light-Triggered Degradable Highly Branched Vinyl Polymer for Efficient mRNA Delivery. 多功能和紫外光触发的可降解高支化乙烯基聚合物用于mRNA的高效传递。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-14 DOI: 10.1021/acs.biomac.5c00555

Wei Sun, Xiaojia Wang, Chenfei Wang, Zhili Li, Rui Guo, Zhedong Ma, Li Luo, Ming Zeng, Dezhong Zhou

{"title":"Multifunctional and UV Light-Triggered Degradable Highly Branched Vinyl Polymer for Efficient mRNA Delivery.","authors":"Wei Sun, Xiaojia Wang, Chenfei Wang, Zhili Li, Rui Guo, Zhedong Ma, Li Luo, Ming Zeng, Dezhong Zhou","doi":"10.1021/acs.biomac.5c00555","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00555","url":null,"abstract":"Vinyl polymers synthesized via radical polymerization of (meth)acrylates are widely used in various biomedical fields. We developed a multifunctional, highly branched vinyl polymer, HPNDN, with ultraviolet (UV) light-triggered degradability for highly efficient mRNA delivery. (2-Nitro-1,3-phenylene) bis(methylene) diacrylate (NPBMDA) was copolymerized with 2-(dimethylamino)ethyl methacrylate (DMAEMA) and 3,3,4,4,5,5,6,6-nonafluorohexyl acrylate (NFHA) by reversible addition-fragmentation chain transfer (RAFT) polymerization followed by end-capping with ethylenediamine (EDA), resulting in HPNDN with a highly branched topological structure, multiple fluorine moieties, and multiple amines. Upon exposure to UV light irradiation, HPNDN degrades within 5 min through the cleavage of the ester groups in the NPBMDA units. Importantly, HPNDN can effectively condense mRNA to form nanosized polyplexes, achieving high transfection efficiency of up to 87.99%, 62.75% and 52.37% in African green monkey kidney (COS-7) cells, human embryonic kidney (293T) cells, and rat schwann (RSC96) cells, respectively, without inducing obvious cytotoxicity.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Physical Characteristics of Disordered Proteins Using Molecular Simulation and Physics-Informed Multiple Machine Learning Strategies. 利用分子模拟和物理信息多机器学习策略预测无序蛋白质的物理特性。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-14 DOI: 10.1021/acs.biomac.5c01118

Diego Linares Gonzalez, Shahana Ibrahim, Swarnadeep Seth, George Atia, Aniket Bhattacharya

{"title":"Prediction of Physical Characteristics of Disordered Proteins Using Molecular Simulation and Physics-Informed Multiple Machine Learning Strategies.","authors":"Diego Linares Gonzalez, Shahana Ibrahim, Swarnadeep Seth, George Atia, Aniket Bhattacharya","doi":"10.1021/acs.biomac.5c01118","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01118","url":null,"abstract":"We introduce a novel hybrid machine learning (ML) framework to predict the radius of gyration and other conformational properties of intrinsically disordered proteins (IDPs). Our model integrates sequence information with physical features derived from a coarse-grained model validated by experimental data. Specifically, we combine hidden states from sequence-based models with 23 physical features projected into a shared latent space, and apply an attention mechanism that assigns weights to each residue to highlight the most informative regions of the sequence. This attention-guided fusion significantly improves predictive accuracy across multiple metrics, including mean absolute percentage error and mean squared error, while also enhancing confidence in the predictions. We trained and evaluated our models on Brownian dynamics (BD) simulation results for approximately 7000 IDPs from the MobiDB database (each with >99% disorder score). We find that sequence-based models consistently outperform feature-only models, with the GRU achieving the best performance among sequence-only approaches. Moreover, combining sequence and feature information further improves accuracy across all architectures, with the hybrid biGRU model delivering the best overall predictive performance. SHAP analysis reveals the relative importance of physical features, offering model explainability, and guiding feature selection. Notably, using a small number of top features often reduces model complexity and improves generalization. Furthermore, an integrated gradient analysis reveals that in addition to the length of the IDPs, the three parameters (sequence charge and hydropathy decoration parameters (SCD and SHD), and charge asymmetry parameter f*) play a key role in the predictions of ML. Our framework provides a fast, interpretable, and scalable tool for predicting IDP behavior, enabling efficient initial screening prior to costly molecular simulations.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Redox Dextran-Based Self-Adapting Adhesive Hydrogels for Subconjunctival Injury to Alleviate Inflammation and Accelerate Healing. 基于氧化还原右旋糖酐的自适应黏附水凝胶用于结膜下损伤减轻炎症和加速愈合。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-14 DOI: 10.1021/acs.biomac.5c01399

Boyuan An, Yuting Deng, Haohao Cui, Mengke Wang, Jiake Li, Qin Zeng, Zhanrong Li, Jingguo Li

{"title":"Redox Dextran-Based Self-Adapting Adhesive Hydrogels for Subconjunctival Injury to Alleviate Inflammation and Accelerate Healing.","authors":"Boyuan An, Yuting Deng, Haohao Cui, Mengke Wang, Jiake Li, Qin Zeng, Zhanrong Li, Jingguo Li","doi":"10.1021/acs.biomac.5c01399","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01399","url":null,"abstract":"Traumatic or chemical injuries to the conjunctival and subconjunctival tissue can lead to defects and associated inflammatory responses, significantly impairing the tissue repair process. Current repair methods lack effective integration of anti-inflammatory action with wound sealing. We combined redox dextran (POD) with poly(vinyl alcohol) (PVA) through physical hydrogen bonds and boronic ester bonds and achieved structural reinforcement through freeze-thawing cycles, developing a novel, self-adapting, anti-inflammatory, dual-network hydrogel adhesive (POAD). The POD surface combines both high degree of freedom primary hydroxyl groups and reactive aldehyde groups, which significantly improves the cohesive and interfacial interactions. In addition, the hydrogel adapts to complex wound shapes and degrades slowly in the presence of reactive oxygen species (ROS), relieving inflammation while making room for tissue regeneration and accelerating the tissue repair process. These properties suggest that POAD hydrogels will be an alternative strategy for future functional ocular surface reconstruction.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleophilic Initiation of Episulfide Anionic Ring-Opening Polymerization by Amino Acids and Oligopeptides. 氨基酸和寡肽引发表硫化物阴离子开环聚合的亲核性研究。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-14 DOI: 10.1021/acs.biomac.5c01251

Emma Mongkhoun, Ons Amamou, Christophe Piesse, Philippe Guégan, Nicolas Illy

{"title":"Nucleophilic Initiation of Episulfide Anionic Ring-Opening Polymerization by Amino Acids and Oligopeptides.","authors":"Emma Mongkhoun, Ons Amamou, Christophe Piesse, Philippe Guégan, Nicolas Illy","doi":"10.1021/acs.biomac.5c01251","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01251","url":null,"abstract":"Peptide-polymer conjugates are promising molecules because they combine the biological functionality of peptides with the versatile properties of polymers, enabling applications in drug delivery, biomaterials, and nanomedicine with enhanced stability, biocompatibility, and tailored functionalities. Until now, the grafting-to approach has been the predominant strategy for synthesizing these biohybrids. By comparison, grafting-from techniques are relatively less diverse. Mainly, radical grafting-from techniques have also been developed, but they present a number of limitations, including a limited variety of polymerizable monomers and the introduction of nonbiodegradable polymer chains. The AROP-based grafting-from strategy offers a promising, yet still underexplored, route for synthesizing peptide-polymer conjugates bearing heteroatom-containing polymer side chains. We report an original AROP grafting-from strategy using primary amines as attachment sites, N-acetyl homocysteine thiolactone as a linker, and propylene sulfide as a monomer. The grafting-from technique was optimized using various protected and unprotected amino acids as model scaffolds. In addition, the regioselective functionalization of primary amine lateral substituents of lysine residues over chain-end amines was demonstrated. The method was then extended to dipeptides and tripeptides. Surprisingly, the grafting-from polymerization was demonstrated to also occur in a controlled manner using oligopeptide initiators bearing unprotected terminal carboxylic acid end-groups. Furthermore, this technique was applied to the introduction of polythioether grafts on the KLVFF peptide sequence (Lys-Leu-Val-Phe-Phe), which is a key recognition motif found in the amyloid-β (Aβ) protein, a protein strongly associated with Alzheimer's disease.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Biomimetic Lotus Root-Inspired Dual-Network Hydrogel Wearable Strain Sensor for Human Motion and Intelligent Traffic Monitoring. 仿生莲藕双网络水凝胶可穿戴应变传感器用于人体运动和智能交通监测。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-14 DOI: 10.1021/acs.biomac.5c01664

Peng Liu, Yuanhang Li, Dong An, Shanshan Guan, Daishuang Zhang, Ning Tang, Hui Li, Yaxin Gu, Xiangyu Li, Yunwu Yu, Yaqi Wang

{"title":"A Biomimetic Lotus Root-Inspired Dual-Network Hydrogel Wearable Strain Sensor for Human Motion and Intelligent Traffic Monitoring.","authors":"Peng Liu, Yuanhang Li, Dong An, Shanshan Guan, Daishuang Zhang, Ning Tang, Hui Li, Yaxin Gu, Xiangyu Li, Yunwu Yu, Yaqi Wang","doi":"10.1021/acs.biomac.5c01664","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01664","url":null,"abstract":"In this study, we developed a novel strain-sensing polyacrylamide (PAM) and sodium alginate (SA)/Cellulose/Pectin-Ca2+ (PSCP-Ca2+) composite hydrogel by integrating cellulose-pectin reinforcing networks into a dual-network matrix composed of PAM and SA, with Ca2+ ions serving as both structural cross-linkers and charge carriers. The PSCP-Ca2+ hydrogel demonstrated excellent mechanical properties (630 kPa stress, 1700% strain, and 5.8 MJ/m3 toughness), good self-healing properties, and high electrical conductivity (0.89 S/m). When employed as a flexible strain sensor, it exhibited a high gauge factor in both tension (GF = 3.74) and compression (GF = 6.48), a broad response range (0-1000% strain), and excellent fatigue resistance (2000+ tensile cycles and 500+ compressive cycles). This work provides valuable insights for designing high-performance hydrogel sensors and advances the practical implementation of flexible electronics in smart wearable devices and intelligent transportation systems.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation of Magnetic Resonance Imaging Loaded Hemostatic Peptide Pentaerythritol Triacrylate Microspheres and Its Embolic Properties In Vivo. 磁共振成像负载止血肽季戊四醇三丙烯酸酯微球的制备及其体内栓塞性能。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c00931

Qinghua Cao, Huinan Wang, Pengchao Xu, Hailin Cong, Bing Yu

{"title":"Preparation of Magnetic Resonance Imaging Loaded Hemostatic Peptide Pentaerythritol Triacrylate Microspheres and Its Embolic Properties In Vivo.","authors":"Qinghua Cao, Huinan Wang, Pengchao Xu, Hailin Cong, Bing Yu","doi":"10.1021/acs.biomac.5c00931","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00931","url":null,"abstract":"Transcatheter arterial chemoembolization (TACE) represents an interventional radiology technique that combines targeted chemotherapy with vascular occlusion. This procedure involves administering chemotherapy-impregnated embolic agents via microcatheters directly into tumor-feeding arteries, achieving dual therapeutic effects through sustained drug release and mechanical obstruction of the vascular supply to malignant lesions. In this study, pentaerythritol triacrylate (PETA) was used as the raw material, and PETA drug-loaded embolization microspheres with hemostatic, magnetic responsiveness, and magnetic resonance imaging abilities were prepared by microfluidic technology. Loaded peptide can accelerate blood coagulation at the embolization site and block blood flow in a short time. Successful arterial embolization was observed in rabbit models, with microsphere deployment achieving the desired hemodynamic obstruction. The multifunctional I3QGK@SPIONs/DOX@PETAMS composite demonstrates synergistic properties including enhanced magnetophoretic response, controlled drug release kinetics, rapid hemostatic action, contrast-enhanced visualization, and precise vascular occlusion, suggesting broad applicability in transarterial chemoembolization and related embolotherapy procedures.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stoichiometric Antibody-Polymer-Drug Conjugate for Effective Low-Dose Treatment of Breast Cancer. 低剂量有效治疗乳腺癌的化学计量抗体-聚合物-药物偶联物。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c00598

Victor Lehot, Ondřej Lidický, Julien Most, Marc Nothisen, Stéphane Erb, Igor Dovgan, Artem Osypenko, Oleksandr Koniev, Sergii Kolodych, Lenka Kotrchová, Guilhem Chaubet, Sarah Cianférani, Tomáš Etrych, Alain Wagner

{"title":"Stoichiometric Antibody-Polymer-Drug Conjugate for Effective Low-Dose Treatment of Breast Cancer.","authors":"Victor Lehot, Ondřej Lidický, Julien Most, Marc Nothisen, Stéphane Erb, Igor Dovgan, Artem Osypenko, Oleksandr Koniev, Sergii Kolodych, Lenka Kotrchová, Guilhem Chaubet, Sarah Cianférani, Tomáš Etrych, Alain Wagner","doi":"10.1021/acs.biomac.5c00598","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00598","url":null,"abstract":"In the past two decades, antibody-drug conjugates (ADCs) have emerged as highly effective targeted therapeutics against cancers. One current path to improve ADCs is to increase the amount of cytotoxic payload delivered to cancer cells by conjugating antibodies with a soluble polymer bearing several drug molecules. However, this approach is challenging due to the high molecular weight of the polymer and the need to strictly control the degree of conjugation to maintain favorable pharmacokinetic and binding profiles. Here, we build from the recent development brought to our automated stoichiometric conjugation device to tackle this challenge. We produced a new format of ADC-like targeted therapy: monoconjugated Antibody-Polymer-Drug Conjugates (APDCs) with enzyme-cleavable linkers, designed to achieve selective delivery of the cytotoxic MMAE to HER2+ cancer cells. We showed the selectivity of our conjugates for HER2+ over HER2- cells in vitro and demonstrated their efficiency in vivo in a SKBR-3-xenografted mouse (NOD-SCID) model.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reactivity Ratios of Biobased Dibutyl Itaconate with Conventional and Renewable (Meth)Acrylates: Influence of Depropagation. 生物基衣康酸二丁酯与常规和可再生（甲基）丙烯酸酯的反应性比率：退化的影响。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c01505

Jyoti Gupta, Radmila Tomovska, Shaghayegh Hamzehlou, Miren Aguirre

{"title":"Reactivity Ratios of Biobased Dibutyl Itaconate with Conventional and Renewable (Meth)Acrylates: Influence of Depropagation.","authors":"Jyoti Gupta, Radmila Tomovska, Shaghayegh Hamzehlou, Miren Aguirre","doi":"10.1021/acs.biomac.5c01505","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01505","url":null,"abstract":"The global push for sustainability has driven interest in renewable monomers such as dibutyl itaconate (DBI). Despite its potential for biobased high-performance polymers, DBI's copolymerization with (meth)acrylates is challenging due to low propagation rates, depropagation at moderate temperatures, and unfavorable reactivity ratios. This study investigates the solution copolymerization of DBI with both conventional, butyl acrylate (BA) and methyl methacrylate (MMA), and biobased (2-octyl acrylate (2-OA) and isobornyl acrylate (IBOA)) monomers. Using in situ 1H NMR and nonlinear least-squares fitting, reactivity ratios were determined: BA/DBI (rBA = 0.68, rDBI = 0.68), MMA/DBI (rMMA = 3.53, rDBI = 0.38), 2-OA/DBI (r2-OA = 1.64, rDBI = 1.44), and IBOA/DBI (rIBOA = 1.87, rDBI = 2.0). The study also clarifies discrepancies in literature values for BA/DBI due to uncertainties in DBI's depropagation rates. DBI copolymers with BA, 2-OA, and IBOA showed a lower composition drift than MMA/DBI, which showed a greater disparity in reactivity ratios.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-Strength Silk from Silkworms Fed Nitrogen-Doped Carbon Quantum Dots. 喂饱掺氮碳量子点的蚕的高强度蚕丝。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c01265

Mengyao Pan, Yuwei Jin, Zheyao Lu, Kejin Zhuo, Ying Mao, Wenbin Jiang, Wenxing Chen, Wangyang Lu

引用次数: 0

RAFT-Polymerized Thermoresponsive Glycopolymer-Grafted-Nanoparticles: Modulation of Lectin Binding. raft -聚合热响应型糖共聚物接枝纳米颗粒：凝集素结合的调节。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c01104

Somdatta Rudra, Saradamoni Mondal, Mithun Chakraborty, Musti J Swamy, Tushar Jana

{"title":"RAFT-Polymerized Thermoresponsive Glycopolymer-Grafted-Nanoparticles: Modulation of Lectin Binding.","authors":"Somdatta Rudra, Saradamoni Mondal, Mithun Chakraborty, Musti J Swamy, Tushar Jana","doi":"10.1021/acs.biomac.5c01104","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01104","url":null,"abstract":"The ability of thermoresponsive glycopolymers to undergo solubility transitions at physiological temperatures can enable the modulation of carbohydrate-lectin interactions. This study examines the binding of thermoresponsive glycopolymer-grafted-silica nanoparticles to lectin concanavalin A at different temperatures. α-d-mannose-hydroxyethyl methacrylate (α-MEMA) and N-isopropylacrylamide (NIPAM) are graft-copolymerized onto silica nanoparticles (SiNPs) via RAFT polymerization to form p(MEMA-co-NIPAM)-grafted-SiNPs. Results show that the sequence and structural arrangement of glycopolymer chains strongly influence lectin binding, especially under temperature modulation. Chains extending outward from the SiNP core yielded strong binding, with an association constant of ∼8 × 106 M-1, which is ∼1200 times higher than that of monomeric methyl-α-d-mannopyranoside, due to greater carbohydrate accessibility to the lectin. In contrast, glycopolymer chains that are randomly arranged/closer to the core showed weak/no binding. The binding is further strengthened below the lower critical solution temperature due to increased polymer solubility, with additional enhancement at longer chain lengths. These observations represent an advancement in the design of functional materials for targeted therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145278455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0