Biomacromolecules最新文献_第3页

Interactions of Protein with Grafted Poly(ethylene oxide) Layer in Two Setups: A Molecular Dynamics Simulation Study. 蛋白质与接枝聚环氧乙烷层在两种情况下的相互作用：分子动力学模拟研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-18 DOI: 10.1021/acs.biomac.5c00574

Tomáš Hrivnák, Dušan Račko, M Natália D S Cordeiro, Zuzana Benková

引用次数: 0

Tert-Butanol as a Structuring Agent for Cellulose Nanocrystal Fluids and Foams. 叔丁醇作为纤维素纳米晶流体和泡沫的结构剂。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-18 DOI: 10.1021/acs.biomac.5c00184

Saül Llácer Navarro, Elliot Orzan, Ratchawit Janewithayapun, Paavo Penttilä, John Andersson, Anna Ström, Roland Kádár, Tiina Nypelö

引用次数: 0

Lignin Changes during Prehydrolysis of Lignocellulosic Biomass for Cellulose Bioconversion: A Review. 木质纤维素生物质纤维素生物转化预水解过程中木质素的变化

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-17 DOI: 10.1021/acs.biomac.5c00612

Nianjie Feng, Xu Yang, Shuang Liang, Xiaotian Zhu, Qian Wu, Ran Bi, Orlando J Rojas

引用次数: 0

Thermally Cured Gelatin-Methacryloyl Hydrogels Form Mechanically Modulating Platforms for Cell Studies. 热固化明胶-甲基丙烯酰水凝胶形成细胞研究的机械调节平台。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-17 DOI: 10.1021/acs.biomac.5c00518

Sara Lipari, Andrea Marfoglia, Giovanni Sorrentino, Sophie Cazalbou, Ludovic Pilloux, Pasquale Sacco, Ivan Donati

{"title":"Thermally Cured Gelatin-Methacryloyl Hydrogels Form Mechanically Modulating Platforms for Cell Studies.","authors":"Sara Lipari, Andrea Marfoglia, Giovanni Sorrentino, Sophie Cazalbou, Ludovic Pilloux, Pasquale Sacco, Ivan Donati","doi":"10.1021/acs.biomac.5c00518","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00518","url":null,"abstract":"Gelatin methacryloyl (GelMA) is a polypeptide derived from the methacryloylation of gelatin and retains the thermoresponsive behavior of gelatin. When cooled, GelMA undergoes a sol-gel transition. By photo-cross-linking GelMA in a heated (\"Hot\") or cooled (\"Cold\") state, it results in a set of hydrogels with distinct properties. To date, the mechanical properties of these resulting hydrogels have not been fully elucidated. Here, we show that \"Cold\" hydrogels are viscoelastic, while \"Hot\" hydrogels are almost completely elastic. These features have remarkable implications for cell-substrate interactions in vitro: here, we show that fibroblasts, when cultured on these different substrates, adhere preferentially to Cold hydrogels. These results suggest that efficient cell adhesion requires specific mechanical properties of the substrate. This novel platform enables the precise control of different mechanical properties of GelMA by simply adjusting the cross-linking temperature, providing a flexible approach for the design of biologically inspired microenvironments in vitro.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TCEP-Enabled Click Modification of Glycidyl-Bearing Polymers with Biorelevant Sulfhydryl Molecules: Toward Chemoselective Bioconjugation Strategies. 生物相关巯基分子在tcep下的点击修饰：化学选择性生物偶联策略。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-17 DOI: 10.1021/acs.biomac.5c00766

Ilaria Porello, Federico Stucchi, Rosachiara Guarini, Giulia Sbaruffati, Francesco Cellesi

{"title":"TCEP-Enabled Click Modification of Glycidyl-Bearing Polymers with Biorelevant Sulfhydryl Molecules: Toward Chemoselective Bioconjugation Strategies.","authors":"Ilaria Porello, Federico Stucchi, Rosachiara Guarini, Giulia Sbaruffati, Francesco Cellesi","doi":"10.1021/acs.biomac.5c00766","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00766","url":null,"abstract":"Thiol-epoxy ring opening is a highly efficient and versatile click reaction for postpolymerization modification, ideal for the conjugation of sulfhydryl-containing biomolecules. This study investigated the reactivity of thiols, disulfides, and amines toward glycidyl-bearing polymers, aiming to optimize thiol conjugation using tris(2-carboxyethyl)phosphine (TCEP) as a disulfide-reducing agent. Epoxide groups were introduced via glycidyl methacrylate (GMA) polymerized by ATRP to yield PGMA homopolymers and poly(ε-caprolactone) (PCL)-based block copolymers. 1H NMR confirmed quantitative thiol functionalization, while amines showed poor reactivity. l-cysteine conjugation further demonstrated the reaction's chemoselectivity. Thioglycerol conjugation yielded poly(2-hydroxy-3-(thioglycerol)propyl methacrylate) (PTGMA), a highly hydroxylated PEG alternative. Functionalization was extended to PCL-b-PGMA and PEGMA-based copolymers, forming amphiphilic nanoparticles via nanoprecipitation. Sequential modification with thioglycerol and the cRGD peptide yielded bioactive, size-controlled nanocarriers. Overall, a robust strategy has emerged for synthesizing multifunctional polymeric nanomaterials. Its compatibility with equimolar reactants under ambient conditions makes it particularly suited for the efficient incorporation of sensitive, high-value biomolecules into targeted drug delivery systems.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioactive Supramolecular Polymers for Skin Regeneration Following Burn Injury. 用于烧伤后皮肤再生的生物活性超分子聚合物。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-16 DOI: 10.1021/acs.biomac.5c01107

Penelope E Jankoski, Abdul-Razak Masoud, Jenna Dennis, Sophia Trinh, Loria R DiMartino, Jessica Shrestha, Luis Marrero, Jeffery Hobden, Jeffrey Carter, Jonathan Schoen, Herbert Phelan, Alison A Smith, Tristan D Clemons

{"title":"Bioactive Supramolecular Polymers for Skin Regeneration Following Burn Injury.","authors":"Penelope E Jankoski, Abdul-Razak Masoud, Jenna Dennis, Sophia Trinh, Loria R DiMartino, Jessica Shrestha, Luis Marrero, Jeffery Hobden, Jeffrey Carter, Jonathan Schoen, Herbert Phelan, Alison A Smith, Tristan D Clemons","doi":"10.1021/acs.biomac.5c01107","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01107","url":null,"abstract":"Severe deep dermal burns present a significant challenge for the clinician, often resulting in complications including infection, scarring, and potentially multisystem organ failure. The current standard of care, which involves debridement and skin coverage, has improved survival rates but remains insufficient for optimal tissue regeneration and functional recovery. Additionally, there can be limited donor skin availability with severe burns, leading to the use of skin substitutes to be applied with varying degrees of success reported. Biomaterial scaffolds, designed to reduce the reliance on skin grafting, could promote improved healing and patient outcomes. Recent research has focused on promoting the proliferative phase of wound healing through the use of extracellular matrix (ECM) mimetic scaffolds; however, these constructs continue to exhibit critical limitations, including mechanical fragility, heightened infection susceptibility, limited morphological conformity to host tissue architecture, and the necessity for secondary surgical intervention for scaffold retrieval. This study presents a bioactive supramolecular polymer capable of rapid self-assembly into nanofibers, which act as a scaffold to promote tissue regeneration following burn injury. The scaffold is biocompatible, biodegradable, and capable of presenting a bioactive peptide designed to reduce acute inflammation and promote keratinocyte migration in the scaffold. The supramolecular polymers significantly accelerated early wound healing in a clinically relevant deep dermal murine burn injury model. This work provides a promising approach to the development of biomaterials that combine both therapeutic strategies, with scaffolding to promote skin regeneration following severe burn injury.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural and Adhesive Properties of Cellulosic Mucilage: A Molecular-Level Investigation. 纤维素黏液的结构和粘附特性：分子水平的研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-16 DOI: 10.1021/acs.biomac.5c00767

Kamonthira Wichai, Xinxin Deng, Helen Gorges, Stanislav N Gorb, Florian Müller-Plathe

引用次数: 0

Oxygen-Supplying Containers to Fabricate Immunomodulatory Hydrogels for Expediting Wound Healing via Acute Oxidative Stress. 氧供应容器制造免疫调节水凝胶加速伤口愈合通过急性氧化应激。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-16 DOI: 10.1021/acs.biomac.5c00374

Jeon Il Kang, Kyung Min Park

{"title":"Oxygen-Supplying Containers to Fabricate Immunomodulatory Hydrogels for Expediting Wound Healing via Acute Oxidative Stress.","authors":"Jeon Il Kang, Kyung Min Park","doi":"10.1021/acs.biomac.5c00374","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00374","url":null,"abstract":"Chronic wounds impose severe health and economic burdens due to persistent inflammation and complications. Immunomodulatory hydrogels have emerged as promising therapies that modulate inflammatory responses for wound healing. Oxygen plays a crucial role in immune modulation and tissue regeneration; however, current oxygen-delivering biomaterials are limited by the mandatory incorporation of oxygen-generating agents and cytotoxic byproducts. Herein, we develop an oxygen-supplying container (Oxygener) via dopamine-mediated catalase immobilization to create oxygen-delivering and immunomodulatory hydrogels. Oxygener supplies oxygen in various solutions by hydrogen peroxide decomposition, producing cytocompatible, oxygen-enriched media for fabricating implantable oxygen-delivering hydrogels. These oxygenated systems facilitate the transition from pro-inflammatory to anti-inflammatory states by reducing macrophage recruitment while improving cellular proliferation and tissue remodeling at the gene and tissue levels in vivo. Our findings establish the minimum oxygen tension and supply duration required for effective wound healing. In summary, Oxygener holds great potential for developing various oxygen-delivering formulations for advanced wound care.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144647973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structurally Colored Thermochromic Gels Derived from Plasmonic Gold Nanoparticles and Cholesteric Hydroxypropyl Cellulose. 由等离子体金纳米粒子和胆甾羟丙基纤维素制备的结构着色热致变色凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-15 DOI: 10.1021/acs.biomac.5c00693

Shunfeng Yu, Ziyi He, Han Tao, Wenwen Fang, Jiaqi Guo, Guang Chu

{"title":"Structurally Colored Thermochromic Gels Derived from Plasmonic Gold Nanoparticles and Cholesteric Hydroxypropyl Cellulose.","authors":"Shunfeng Yu, Ziyi He, Han Tao, Wenwen Fang, Jiaqi Guo, Guang Chu","doi":"10.1021/acs.biomac.5c00693","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00693","url":null,"abstract":"The integration of functional components into thermochromic photonic crystals has attracted considerable interest due to their potential for developing stimuli-responsive materials with distinctive optical characteristics. In this study, we demonstrate a series of optically tunable thermochromic gels, formed through the coassembly of gold nanoparticles with hydroxypropyl cellulose (HPC) at high concentrations (60-68 wt %), producing vibrant structural colors with enhanced light absorption. These composites not only preserve the chiral self-assembly of HPC in the presence of nanoparticles but also introduce tunable photonic-plasmonic coupling that responds to both temperature and concentration variations. Moreover, by exploiting the chiral light-matter interactions between the gold nanoparticles and the HPC, we observed a pronounced temperature-sensitive plasmonic optical activity, characterized by a strong negative peak on CD spectra, resulting from the chiral photonic modulation of the HPC. This approach for fabricating optically tunable thermochromic materials with engineered photonic-plasmonic coupling opens new avenues for advanced optical applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inversion of Enzymatic Enantiocatalysis Mediated by Biomolecular Condensates. 生物分子凝聚物介导的酶对映催化逆转。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-15 DOI: 10.1021/acs.biomac.5c00520

Shikha Shikha, Priyanka Priyanka, Subhabrata Maiti

引用次数: 0