Biomacromolecules最新文献_第3页

NMR Insights into Nanoscale Molecular Interactions between Nucleic Acids and Pristine Graphene in Aqueous Solution. 核磁共振洞察纳米级分子相互作用之间的核酸和原始石墨烯在水溶液中。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-13 DOI: 10.1021/acs.biomac.5c01357

Budoor S Al Umairi, David J Clarke, Elena V Bichenkova

{"title":"NMR Insights into Nanoscale Molecular Interactions between Nucleic Acids and Pristine Graphene in Aqueous Solution.","authors":"Budoor S Al Umairi, David J Clarke, Elena V Bichenkova","doi":"10.1021/acs.biomac.5c01357","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01357","url":null,"abstract":"Delivery of oligonucleotide therapeutics to the sites of biological action is challenged by their large size and charge. Graphene can serve as a nanocarrier for their transport, but the nature of their molecular interactions with pristine graphene in water is still poorly understood. Here, we investigated the binding of short synthetic DNAs and their building blocks with graphene in water using NMR by following their signals upon exposure to graphene. Individual nucleobases displayed strong affinity toward graphene: adenine > guanine > cytosine > thymine. Single-stranded DNAs showed ≈2-3 times weaker binding affinities, with strong influence from nucleobase composition, length, and structural complexity. DNA duplexes were similarly able to interact with graphene, and without any structural disruption. Incorporation of polyaromatic pyrene \"anchors\" into nucleic acid sequences considerably reinforced their affinity to graphene and allowed graphene to not only distinguish purine-rich from pyrimidine-rich sequences more distinctly but also better discriminate single-stranded from double-stranded DNA.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile Exfoliation of Silk Nanofibrils Enabled by Hydrogen Bond Network Reconfiguration in Deep Eutectic Solvent/Water Systems. 深层共晶溶剂/水体系中氢键网络重构使丝纳米原纤维易于脱落。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-11 DOI: 10.1021/acs.biomac.5c01371

Wen-Qian Lian, Zi-Yang Fan, Sheng He, Shu-Ling Yang, Gui-Chuan Wei, Rui-Ying Bao, Wei Yang

{"title":"Facile Exfoliation of Silk Nanofibrils Enabled by Hydrogen Bond Network Reconfiguration in Deep Eutectic Solvent/Water Systems.","authors":"Wen-Qian Lian, Zi-Yang Fan, Sheng He, Shu-Ling Yang, Gui-Chuan Wei, Rui-Ying Bao, Wei Yang","doi":"10.1021/acs.biomac.5c01371","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01371","url":null,"abstract":"Silk nanofibers (SNFs) with distinctive physicochemical properties are promising nanoscale building blocks of porous materials, yet high-yield exfoliation using green solvents remains challenging. Herein, hydrogen-bonding small molecules (water, methanol, and ethanol) were introduced into deep eutectic solvents (DESs) to reconfigure hydrogen-bond networks and promote exfoliation. Among them, DES/water mixtures proved most effective: adding 30 wt % water reduced average SNF diameter from 239 ± 184 nm to 109 ± 27 nm and delivered a yield of 98.3% within 24 h. The improvement is attributed to hydrogen-bond reorganization, decreased viscosity, and enhanced proton transfer. The resulting SNFs preserved silk's hierarchical structures and were assembled into flexible membranes with a tensile strength of 34 MPa. These porous membranes effectively removed microplastics, with rejection rates above 91% through combined size exclusion and adsorption. This work demonstrates DES/water mixtures as sustainable solvent systems for scalable SNF production and the fabrication of high-performance membranes for water purification.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quaternized Nylon-6 Polymers via Ring-Opening Polymerization of Cyclic Lysine Derivatives: A Versatile Antibacterial Platform. 环赖氨酸衍生物开环聚合的季铵盐化尼龙-6聚合物：一个多功能抗菌平台。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-11 DOI: 10.1021/acs.biomac.5c01523

Yan Yan, Jinlong Chen, Qun-Liang Zhang, Youhua Tao

{"title":"Quaternized Nylon-6 Polymers via Ring-Opening Polymerization of Cyclic Lysine Derivatives: A Versatile Antibacterial Platform.","authors":"Yan Yan, Jinlong Chen, Qun-Liang Zhang, Youhua Tao","doi":"10.1021/acs.biomac.5c01523","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01523","url":null,"abstract":"Nylon-6, while commercially essential, has proven challenging to endow with persistent antibacterial properties due to the lack of efficient and facile synthetic approaches. Poly(ε-lysine) derivatives have attracted considerable research attention due to their structural backbone similarity to that of nylon-6. Capitalizing on this structural similarity, herein, we achieved hydrophobicity-tunable quaternized nylon-6 polymers through rational design of side-chain structures in lysine-derived cyclic monomers and controlled quaternization reactions. By precisely controlling the quaternization process, amphiphilic quaternized nylon-6 polymers with adjustable hydrophobicity and cationic charge density were successfully prepared, enabling systematic evaluation of their broad-spectrum antimicrobial properties. Notably, enhanced hydrophobicity was found to significantly improve antibacterial efficacy against both Escherichia coli and its biofilms, with the amphiphilic polymers demonstrating superior antimicrobial performance. Furthermore, these amphiphilic quaternized nylon-6 polymers exhibited a thermoresponsive behavior. This work proposes a new design strategy for antimicrobial nylon-6 polymers, enabling the simultaneous enhancement of antibacterial functionality and the incorporation of temperature-responsive properties.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Injectable Hydrogel with Phase-Programmed Release of Centella asiatica Nanocomposites for Infection Control and Scarless Wound Healing. 积雪草纳米复合材料的注射相程序释放水凝胶用于感染控制和无疤痕伤口愈合。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-11 DOI: 10.1021/acs.biomac.5c01620

Guangxu Wang, Qirui Gong, Yujie Zhao, Banchao Ruan, Lihong Fan, Tengda Ma, Xiaolong Cao, Dan Shu, Shuna Zhang, Yiju Xie, Yue Zhang, Yingying Chu

{"title":"Injectable Hydrogel with Phase-Programmed Release of Centella asiatica Nanocomposites for Infection Control and Scarless Wound Healing.","authors":"Guangxu Wang, Qirui Gong, Yujie Zhao, Banchao Ruan, Lihong Fan, Tengda Ma, Xiaolong Cao, Dan Shu, Shuna Zhang, Yiju Xie, Yue Zhang, Yingying Chu","doi":"10.1021/acs.biomac.5c01620","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01620","url":null,"abstract":"Infected wounds provoke persistent inflammation that hinders healing. Here, we developed a phase-adaptable, injectable hydrogel (PAC@TAP) that delivers sequential antibacterial, antioxidant, anti-inflammatory, and regenerative effects. Bioactive nanoparticles (AC@TAP) were prepared by loading Centella asiatica onto polydopamine, in situ polymerizing silver, and coating with tannic acid, then embedded in a dynamic QCS/OHA/PVA matrix. Reversible Schiff-base, ionic, and borate-ester cross-links (PVA/Ca2+/CPBA) endow injectability, self-healing, and strong tissue adhesion with PAC@TAP hydrogel. The composite hydrogel exhibits potent antibacterial activity, efficient ROS scavenging, and immunomodulation effects, thereby accelerating scar-minimizing healing of infected wounds. In vitro, PAC@TAP is cytocompatible and enhances cell migration. In vivo, near-infrared stimulation accelerates closure, dampens inflammation, and promotes angiogenesis. This integrated design uniquely couples antimicrobial defense with immune regulation and tissue regeneration, offering a promising strategy for advanced infected wound therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics. Unimer交换作为通过胶束动力学编程酶降解的工具。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-10 DOI: 10.1021/acs.biomac.5c00955

Shahar Tevet, Michal Brodsky, Roey J Amir

{"title":"Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics.","authors":"Shahar Tevet, Michal Brodsky, Roey J Amir","doi":"10.1021/acs.biomac.5c00955","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00955","url":null,"abstract":"A key challenge in designing enzyme-responsive micellar nanocarriers lies in balancing their stability and enzymatic degradation. While it has been widely assumed that the micelle-unimer exchange governs enzyme accessibility to the hydrophobic blocks, this relationship had not been directly demonstrated. Here, to uncover this long-assumed mechanistic link, we synthesized a set of triblock amphiphiles that convert by an in situ transition to diblock amphiphiles via reductive cleavage of a central disulfide bond. In parallel, hydrophobicity was independently tuned by modifying the aliphatic end-groups. Enzymatic degradation studies and Förster resonance energy transfer (FRET)-based exchange assays showed two consistent trends across all systems: increasing hydrophobicity led to slower micelle-unimer exchange and reduced enzymatic degradation rates, while transition to diblock consistently enhanced both. These results provide direct evidence that exchange kinetics govern enzymatic degradation and lay the mechanistic foundation for overcoming the stability-degradability barrier for enzyme-responsive micelles by applying architectural transitions as a molecular programming tool.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cationic Antimicrobial Copolymers Reveal Immunomodulatory Properties in Lipopolysaccharide Stimulated Macrophages in Vitro. 阳离子抗菌共聚物在体外脂多糖刺激巨噬细胞中显示免疫调节特性

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-10 DOI: 10.1021/acs.biomac.5c01280

Sophie Laroque, James Harris, Santhosh Kalash Rajendrakumar, Vadim Vasilyev, Jaspreet Grewal, Robert Dallmann, Katherine E S Locock, Sébastien Perrier

{"title":"Cationic Antimicrobial Copolymers Reveal Immunomodulatory Properties in Lipopolysaccharide Stimulated Macrophages in Vitro.","authors":"Sophie Laroque, James Harris, Santhosh Kalash Rajendrakumar, Vadim Vasilyev, Jaspreet Grewal, Robert Dallmann, Katherine E S Locock, Sébastien Perrier","doi":"10.1021/acs.biomac.5c01280","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01280","url":null,"abstract":"Antimicrobial polymers, which have emerged as a promising alternative to antibiotics in the fight against antimicrobial resistance, are based on the design of cationic host defense peptides (CHDPs). Being part of the mammalian innate immune system, CHDPs possess both antimicrobial and immunoregulatory effects to manage bacterial infections. However, the immunomodulatory effects of antimicrobial polymers remain largely unexplored. Within this work, a library of 15 copolymers was synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and their abilities to modulate pro-inflammatory pathways in lipopolysaccharide (LPS)-activated murine and human macrophages were investigated. We found that two diblock copolymers with cationic units copolymerized with either apolar or hydrophilic comonomers appeared to have anti-inflammatory activity through suppression of the activation of the nuclear factor kappa-light-chain enhancer of the activated B cell (NF-κB) signaling pathway, scavenging of reactive oxygen species, and reduced production of the pro-inflammatory cytokine interleukin-6 (IL-6). Furthermore, the cationic-apolar copolymer exhibits significant antimicrobial activity against P. aeruginosa. Thus, this promising copolymer holds potential as a dual-action therapeutic, effectively combating bacterial infections while curbing prolonged inflammation and thereby preventing sepsis at the site of infection.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recyclable Polysaccharide-Based Supramolecular Ionogel Electrolytes for Flexible Supercapacitors. 柔性超级电容器用可回收多糖基超分子离子凝胶电解质。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-10 DOI: 10.1021/acs.biomac.5c01378

Binhu Zou, Huizhi Qin, Lijun Ye, Yuanyuan Liang, Yongjin Li

{"title":"Recyclable Polysaccharide-Based Supramolecular Ionogel Electrolytes for Flexible Supercapacitors.","authors":"Binhu Zou, Huizhi Qin, Lijun Ye, Yuanyuan Liang, Yongjin Li","doi":"10.1021/acs.biomac.5c01378","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01378","url":null,"abstract":"Growing concerns over the environmental impact of fossil fuels have spurred the development of green and renewable materials for advanced electrochemical energy storage (EES) devices. Herein, a supramolecular ionogel polymer electrolyte based on glycol chitosan (GC) and imidazolium-based ionic liquids (IL) was developed. The as-fabricated optimized GC0.1-DMSO1/IL1 supramolecular ionogel electrolytes exhibited an impressive conductivity of 4.4 mS cm-1 at 25 °C, enabling a supercapacitor with a stable voltage window of 2.5 V. The supercapacitor exhibited a specific capacitance of 40.0 F g-1 at a current density of 1 A g-1 and achieved a maximum energy density of 22.2 Wh kg-1 at a power density of 770 W kg-1. After over 700 charge-discharge cycles at 1 Ag-1, a capacitance retention of 94.7% was obtained. Moreover, the noncovalent bonded GC0.1-DMSO1/IL1 could be easily recycled in water without generating any environmental hazards. This strategy offers new insights into the potential of polysaccharide-based supramolecular ionogel electrolytes for flexible and sustainable EES applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145273191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Sucrose and Sucralose on the Gelation of Gelatin. 蔗糖和三氯蔗糖对明胶凝胶化的影响。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-09 DOI: 10.1021/acs.biomac.5c01715

Yasuyuki Maki, Koichi Matsuo, Masahiko Annaka

引用次数: 0

Antiangiogenic Antheraea pernyi Silk Fibroin Nanocarrier As an Advanced Dual-Gene Delivery Platform for Lung Tumor Suppression. 抗血管生成柞蚕丝素纳米载体作为肺肿瘤抑制的先进双基因传递平台。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-09 DOI: 10.1021/acs.biomac.5c01484

Jing Qu, Xueping Liu, Jiru Jia, Wei Ma, Qi Xiao, Mingzhong Li

{"title":"Antiangiogenic Antheraea pernyi Silk Fibroin Nanocarrier As an Advanced Dual-Gene Delivery Platform for Lung Tumor Suppression.","authors":"Jing Qu, Xueping Liu, Jiru Jia, Wei Ma, Qi Xiao, Mingzhong Li","doi":"10.1021/acs.biomac.5c01484","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01484","url":null,"abstract":"The cationic Antheraea pernyi silk fibroin (CASF)-bridged endostatin peptide 2 (ES2) electrostatically coated the inhibitor of growth 4 (ING4)/interleukin-24 (IL-24) dual-gene coexpression plasmid DNA (pDNA) to construct a CASF-ES2/pDNA nanocarrier, which significantly enhanced gene expression and induced apoptosis by strengthening cell adhesion and endocytosis. The continuously released ES2 contributed to its specific action on HUVECs, including inducing apoptosis and hindering migration, invasion, and tube formation, as well as inhibiting angiogenesis in the chorioallantoic membrane. In the treatment of mice with A549 xenograft tumors, CASF-ES2/pDNA arrested the growth cycle of tumor cells and activated the Bcl-2/Bax/C Caspase-3 apoptotic pathway, promoting cell apoptosis and tissue collapse. Additionally, the released ES2 prevented the formation of tumor neovasculature, cut off the nutrient channels for tumor growth, and synergistically inhibited the development and metastasis of xenograft tumors. This safe and antiangiogenic gene vector shows great promise for application in long-term antitumor and antimetastatic therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Photoresin Synthesis via Reactive Diluents for Vat Photopolymerization. 用活性稀释剂原位合成还原光聚合光树脂。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-09 DOI: 10.1021/acs.biomac.5c01471

Tao Zhang, Vincent S D Voet, Rudy Folkersma, Katja Loos

{"title":"In Situ Photoresin Synthesis via Reactive Diluents for Vat Photopolymerization.","authors":"Tao Zhang, Vincent S D Voet, Rudy Folkersma, Katja Loos","doi":"10.1021/acs.biomac.5c01471","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01471","url":null,"abstract":"As climate change intensifies, there is a pressing demand for sustainable alternatives to fossil-derived photoresins in additive manufacturing. While biobased systems have been explored, many rely on hazardous solvents, limiting their environmental benefits. Here, we report a one-pot, purification-free strategy for synthesizing renewable, high-performance photoresins using furan-based monomers derived from lignocellulosic biomass. Furfuryl methacrylate and 4,4'-bismaleimidodiphenylmethane (BSM) were integrated into methacrylate networks via Diels-Alder (DA) chemistry, with 2-hydroxyethyl methacrylate (HEMA) enabling high conversion (93%) under optimized conditions. Mechanical testing revealed that UV postcuring enhanced tensile strength, whereas excessive UV or solvent exposure caused oligomer leaching. Thermal postcuring activated retro-DA reactions, improving mechanical robustness and shape memory performance. Comparative studies showed aromatic DA derivatives offered superior programmability, while aliphatic analogs provided higher renewable carbon content with stable printability. This scalable, solvent-free strategy establishes a green chemistry framework for sustainable, high-performance photoresins, advancing additive manufacturing toward circular economy objectives.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0