Biomacromolecules最新文献_第3页

Synthesis and Characterization of Free Radical Scavenging Dendrimer Nanogels via Cross-Linking Reaction-Enabled Flash Nanoprecipitation. 通过交联反应激活的纳米闪蒸法合成和表征清除自由基的树状聚合物纳米凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-07 DOI: 10.1021/acs.biomac.5c00050

Lin Qi, Da Huang, Huari Kou, Anna Chernatynskaya, Nuran Ercal, Hu Yang

{"title":"Synthesis and Characterization of Free Radical Scavenging Dendrimer Nanogels via Cross-Linking Reaction-Enabled Flash Nanoprecipitation.","authors":"Lin Qi, Da Huang, Huari Kou, Anna Chernatynskaya, Nuran Ercal, Hu Yang","doi":"10.1021/acs.biomac.5c00050","DOIUrl":"10.1021/acs.biomac.5c00050","url":null,"abstract":"This work reports the development and evaluation of dendrimer-based nanogels based on polyamidoamine (PAMAM) dendrimer generation 5, engineered to act as a carrier with reactive oxygen species (ROS)-scavenging capabilities. We developed a cross-linking reaction-enabled flash nanoprecipitation method in which the cross-linking reaction occurs during the flash nanoprecipitation process to form a cross-linked nanostructure. Using this approach, an N-hydroxysuccinimide (NHS)-functionalized ROS-responsive thioketal cross-linker (TK-NHS) was synthesized and utilized to cross-link DAB-core PAMAM dendrimer G5, resulting in the formation of G5-TK nanogels. The resulting nanogels were characterized using dynamic light scattering and transmission electron microscopy, and their cytocompatibility, irritancy, cellular uptake, and ROS scavenging activity were assessed. We confirmed the ROS scavenging capability of these nanogels and observed favorable safety profiles. The G5-TK nanogels can be further developed as carriers for therapeutic delivery applications to treat oxidative stress-related pathological conditions.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"2986-2995"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water-Soluble Unconventional Hyperbranched Polyborosiloxane Derivatives for Temperature Sensing in Living Cells. 水溶性非常规超支化聚硼硅氧烷衍生物在活细胞中的温度传感。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-08 DOI: 10.1021/acs.biomac.5c00105

Yanyun He, Rui Wu, Zheng Li, Yekun Zhang, Wenyan Liu, Weixu Feng, Hongxia Yan

{"title":"Water-Soluble Unconventional Hyperbranched Polyborosiloxane Derivatives for Temperature Sensing in Living Cells.","authors":"Yanyun He, Rui Wu, Zheng Li, Yekun Zhang, Wenyan Liu, Weixu Feng, Hongxia Yan","doi":"10.1021/acs.biomac.5c00105","DOIUrl":"10.1021/acs.biomac.5c00105","url":null,"abstract":"Fluorescent polymeric thermometers, despite their noninvasive detection and rapid response for intracellular temperature monitoring, face challenges in achieving excellent biocompatibility and high sensitivity. Herein, we synthesized a water-soluble unconventional temperature-sensitive fluorescent polymer (P2) through terminally grafting poly(N-vinylcaprolactam) (PNVCL) onto hyperbranched polyborosiloxane (P1). The P2 exhibited efficient red-light emission and good photostability. Particularly, when the temperature rises, the PNVCL units transform from hydrophilic to hydrophobic, resulting in the dislocation of local segments of P2, suppressing radiative transitions and simultaneously weakening its through-space conjugation, further reducing its fluorescence intensity, and endowing the P2 with a high temperature-sensing sensitivity of 10.06% °C-1. Finally, the real-time monitoring of intracellular temperature variation was further conducted. This work not only develops promising thermochromic materials for intracellular temperature sensing but also provides further insight into the temperature-sensing mechanism of unconventional fluorescent polymers.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"3011-3020"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reverse Block Sequence in Self-Immolative Poly(benzyl ether)-Based Amphiphiles for Tailoring End Groups and Self-Assembly Behavior. 自焚聚苯醚基两亲体中端基裁剪和自组装行为的反向嵌段序列。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-30 DOI: 10.1021/acs.biomac.4c01845

Ji Woo Kim, Tae-Il Kang, Eunpyo Choi, Hyungwoo Kim

引用次数: 0

Redox-Responsive PEO-b-PCL-Based Block Copolymers for Synergistic Drug Delivery and Bioimaging in Cancer Cells. 基于peo -b- pcl的氧化还原响应嵌段共聚物在癌细胞中的协同药物传递和生物成像。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-23 DOI: 10.1021/acs.biomac.5c00102

Bhagyashree Kulkarni, Shahad AlOtaiby, Niveen M Khashab, Nikos Hadjichristidis

{"title":"Redox-Responsive PEO-b-PCL-Based Block Copolymers for Synergistic Drug Delivery and Bioimaging in Cancer Cells.","authors":"Bhagyashree Kulkarni, Shahad AlOtaiby, Niveen M Khashab, Nikos Hadjichristidis","doi":"10.1021/acs.biomac.5c00102","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00102","url":null,"abstract":"Stimuli-responsive polymer-based nanocarriers enhance the drug delivery efficiency by enabling targeted release at tumor sites. However, integrating therapeutic and diagnostic functions into a single nanoplatform while maintaining control over both remains a significant challenge. This study presents a stimuli-responsive, multifunctional poly(ethylene oxide)-b-poly(ε-caprolactone) (PEO-b-PCL) nanocarrier for combination cancer therapy and bioimaging. The system codelivers chlorambucil (CHL) and methotrexate (MTX) to enhance therapeutic efficacy and overcome multidrug resistance. A redox-responsive disulfide linker enables CHL release in the tumor's glutathione-rich environment, ensuring selective drug activation. Additionally, an aggregation-induced emission (AIE) fluorophore, tetraphenylethylene (TPE), facilitates the monitoring of cellular uptake and drug release. The resulting TPE-(PEO-b-PCL)-S-S-CHL (P3) micelles encapsulated with MTX (P3-MTX) exhibited favorable size, morphology, and enhanced cytotoxicity, demonstrating a synergistic effect in combination therapy. Confocal laser scanning microscopy (CLSM) confirmed intracellular uptake by using TPE-based fluorescence. Thus, these nanocarriers offer a promising theranostic platform for simultaneous cancer treatment and monitoring.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"3032-3043"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two-Step Carboxymethylation of Cellulose from Halocynthia roretzi Using Ionic Liquid. 离子液体对盐藻纤维素两步羧甲基化的研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-18 DOI: 10.1021/acs.biomac.4c01770

Nuri Han, Seung Hyeon Weon, Jiwoo Han, Jeong Eun Cha, Sang Hyun Lee

{"title":"Two-Step Carboxymethylation of Cellulose from Halocynthia roretzi Using Ionic Liquid.","authors":"Nuri Han, Seung Hyeon Weon, Jiwoo Han, Jeong Eun Cha, Sang Hyun Lee","doi":"10.1021/acs.biomac.4c01770","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01770","url":null,"abstract":"Water-soluble carboxymethylated tunicate cellulose (CMTC) was produced using cellulose from Halocynthia roretzi, known for its uniquely high molecular weight and crystallinity. Among various known methods for cellulose carboxymethylation tested in this study, only the homogeneous method using LiClO4 yielded water-soluble CMTC. However, industrial application of this method is hindered by LiClO4's toxicity, explosiveness, and high cost. Therefore, we developed a two-step carboxymethylation process utilizing [Emim][Ac], effectively converting crystalline cellulose into an amorphous form and reducing both the degree of polymerization (DP) and polydispersity index (PDI). CMTC prepared by this two-step method exhibited a high degree of substitution (DS = 1.94), excellent water solubility (>100 mg/g), and superior thermal stability. Compared to the LiClO4-based CMTC, our product contained only 5% unmodified glucose and demonstrated significantly enhanced thickening properties, with 8-fold greater viscosity in 5% aqueous solutions. Structural properties were confirmed via HPLC, 1H NMR, XRD, FT-IR, and TGA analyses.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"2909-2921"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structurally Engineered SO₂-Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity. 结构工程化的so2释放聚合物纳米组件具有广谱抗菌活性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-24 DOI: 10.1021/acs.biomac.5c00281

Anushree Mondal, Tanushree Mondal, Subhamoy Jana, Arindam Banerjee, Priyadarsi De

{"title":"Structurally Engineered SO2-Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity.","authors":"Anushree Mondal, Tanushree Mondal, Subhamoy Jana, Arindam Banerjee, Priyadarsi De","doi":"10.1021/acs.biomac.5c00281","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00281","url":null,"abstract":"Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative for treating diseases, including bacterial infections. However, current systems often target only specific bacterial strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, DAPx copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic cationic residues outward and encapsulating hydrophobic SO2-releasing moieties within the core to enable controlled and sustained release of SO2 in the presence of glutathione (GSH). In vitro studies reveal excellent biocompatibility of DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm bacterial eradication via membrane disruption and reactive oxygen species generation. This study underscores the remarkable efficacy of SO2-releasing cationic polymers in resisting bacterial infections.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"3200-3212"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Dynamics Simulation of Self-Assembly and Tensile Deformation of Silk-Mimetic Polymers. 仿丝聚合物自组装和拉伸变形的分子动力学模拟。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-21 DOI: 10.1021/acs.biomac.4c01623

Jeongae Kim, Yanming Zhang, Shweta Burgula, R Helen Zha, Yunfeng Shi

引用次数: 0

PLA Block Polymers: Versatile Materials for a Sustainable Future. 聚乳酸嵌段聚合物：可持续未来的多用途材料。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-07 DOI: 10.1021/acs.biomac.5c00161

Daniel M Krajovic, Margaret S Kumler, Marc A Hillmyer

{"title":"PLA Block Polymers: Versatile Materials for a Sustainable Future.","authors":"Daniel M Krajovic, Margaret S Kumler, Marc A Hillmyer","doi":"10.1021/acs.biomac.5c00161","DOIUrl":"10.1021/acs.biomac.5c00161","url":null,"abstract":"Block polymers present an almost endless realm of possibilities to develop functional materials for myriad applications. The established self-assembly of block polymers allows researchers to access properties that are inaccessible in homopolymers. However, there is a need to develop more sustainable options than the current commodity block polymers. Derived from renewable resources and industrially compostable, poly(lactide) (PLA) is at the forefront of technological advancements in sustainable block polymers. Its material properties including high stiffness, relatively high glass transition temperature, and semicrystallinity in isotactic versions lend themselves to many applications, and its ease of synthesis provides a well-established platform for developing high-performance materials. This Perspective highlights recent advancements associated with PLA-containing block polymers, including their syntheses, mesostructural considerations, and mechanical properties, from resilient elastomers to tough plastics. We also give our perspective on the subfield of PLA block polymers, our outlook on the future, and our assessment of exciting developments yet to come.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"2761-2783"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric Properties of Telomeric G-Quadruplex Multimers: Effects of Chemically Inert Crowders. 端粒g -四聚体多聚物的聚合性质：化学惰性聚合剂的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-08 DOI: 10.1021/acs.biomac.5c00176

Deniz Mostarac, Mattia Trapella, Luca Bertini, Lucia Comez, Alessandro Paciaroni, Cristiano De Michele

引用次数: 0

Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages. 用于DNA合成的坚固的光可切割连接物：使可见光触发的反义寡核苷酸在3D DNA纳米笼中释放。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-24 DOI: 10.1021/acs.biomac.5c00162

Hoi Man Leung, Hau Yi Chan, Maxime Klimezak, Ling Sum Liu, Pierre Karam, Alexandre Specht, Frédéric Bolze, Pik Kwan Lo

{"title":"Robust Photocleavable Linkers for DNA Synthesis: Enabling Visible Light-Triggered Antisense Oligonucleotide Release in 3D DNA Nanocages.","authors":"Hoi Man Leung, Hau Yi Chan, Maxime Klimezak, Ling Sum Liu, Pierre Karam, Alexandre Specht, Frédéric Bolze, Pik Kwan Lo","doi":"10.1021/acs.biomac.5c00162","DOIUrl":"10.1021/acs.biomac.5c00162","url":null,"abstract":"We synthesized new para-dialkylaminonitrobiphenyl (ANBP) derivatives, s-ANBP and t-ANBP, functionalized with dimethyltrityl and phosphoramidite groups for incorporation into DNA backbones as photocleavable linkers via solid-phase synthesis. Both derivatives exhibited excellent chemical stability under diverse conditions, including acidic, alkaline, and high-salt environments and elevated temperatures. Their incorporation into DNA influenced duplex stability and antisense oligonucleotide (ASO) dissociation efficiency, depending on the number of ANBP units and adjacent nucleotide deletions. The s-/t-ANBP-conjugated DNA showed efficient one-photon photolysis at 415 nm and enhanced two-photon absorption for extended π-system in t-ANBP, with δuΦu values of 1.6 GM (740 nm) and 2.7 GM (800 nm). ANBP-conjugated DNA was used to construct a 3D DNA nanocage capable of light-triggered ASO 4625 release, validated by an in vitro RNA digestion assay, confirming antisense functionality. This platform demonstrates precise, light-mediated therapeutic delivery and offers potential for broader applications in drug delivery and clinical use.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"3113-3127"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0