Biomacromolecules最新文献_第3页

Effects of Silk Fibroin Hydrogel Degradation on the Proliferation and Chondrogenesis of Encapsulated Stem Cells.

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-22 DOI: 10.1021/acs.biomac.4c01676

Tianhao Zhu, Guolong Cai, Weikun Zhao, Xiang Yao, Yaopeng Zhang

引用次数: 0

Biodegradable Polymeric Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing. 具有增强止血和抗菌性能的可生物降解聚合物微球，用于伤口愈合。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-21 DOI: 10.1021/acs.biomac.4c01545

Xuelian Hu, Sai Li, Yuji Pu, Bin He

{"title":"Biodegradable Polymeric Microspheres with Enhanced Hemostatic and Antibacterial Properties for Wound Healing.","authors":"Xuelian Hu, Sai Li, Yuji Pu, Bin He","doi":"10.1021/acs.biomac.4c01545","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01545","url":null,"abstract":"Hemostasis is the initial step in wound healing, yet significant challenges, such as massive bleeding and infection, often arise. In this study, we developed amphiphilic biodegradable polyester-based segmented polyurethane (SPU) microspheres modified with epigallocatechin gallate (EGCG)-Ag nanoparticles and calcium-alginate cross-linking shell, combining blood absorption with the pro-coagulation properties of Ca2+ and the negative charge of EGCG for synergistic hemostatic effects across various stages of the coagulation cascade. The in vitro blood clotting time of the SPU@EAg@CaAlg microsphere (328.7 s) was reduced by half compared to the SPU microsphere (685.0 s). SPU@EAg@CaAlg exhibited a reduced hemostatic time and blood loss in three rat hemostatic models. Additionally, EGCG-Ag nanoparticles imparted strong antibacterial and anti-inflammatory properties both in vitro and in vivo. In vivo infected wound model demonstrated that SPU@EAg@CaAlg effectively eliminated bacteria and reduced the levels of pro-inflammatory factors, thereby promoting wound healing. Thus, the modified SPU microspheres present a promising candidate for effective hemostatic applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strong Hydrophobic Interaction of High Molecular Weight Chitosan in Aqueous Solution. 高分子量壳聚糖在水溶液中的强疏水相互作用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-21 DOI: 10.1021/acs.biomac.4c01333

Haeun Kwon, Jieun Choi, Chanoong Lim, Junseong Kim, Asila Osman, Yongseok Jho, Dong Soo Hwang, Dong Woog Lee

引用次数: 0

Swelling Degree of Polyelectrolyte Layers Determined by an Electrochemical Quartz Crystal Microbalance. 电化学石英晶体微天平测定聚电解质层的溶胀程度。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-21 DOI: 10.1021/acs.biomac.4c01205

Christian Leppin, Agata Pomorska, Maria Morga, Pawel Pomastowski, Piotr Fijałkowski, Aneta Michna, Diethelm Johannsmann

{"title":"Swelling Degree of Polyelectrolyte Layers Determined by an Electrochemical Quartz Crystal Microbalance.","authors":"Christian Leppin, Agata Pomorska, Maria Morga, Pawel Pomastowski, Piotr Fijałkowski, Aneta Michna, Diethelm Johannsmann","doi":"10.1021/acs.biomac.4c01205","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01205","url":null,"abstract":"Various polycations and polyanions were sequentially adsorbed onto the gold electrode of a quartz crystal microbalance with dissipation monitoring. The study focused on determining the adsorption kinetics, viscoelastic properties, and electroresponsivity of polyelectrolyte layers. For the first time, it was demonstrated that the structure (compact or expanded) of the layers can be determined by electroresponsivity. Viscoelastic modeling alone did not provide a conclusive answer as to whether the layers were compact or expanded. The study was further enriched by streaming potential and contact angle measurements, where polyelectrolyte multilayers were formed on mica. It was found that successive adsorption of layers led to periodic inversion of the zeta potential. Systematic differences were observed between the different top layers, which were explained by intermixing between layers. The presence or absence of interpenetration, as determined by the measurements of streaming potential and contact angles, correlated well with electroresponsivity.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering of Silkworm Tyrosyl-tRNA Synthetase Variants to Create Halogenated Silk Fiber with Improved Thermal Stability. 蚕酪氨酸- trna合成酶变异体工程制备热稳定性更好的卤化蚕丝纤维。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-21 DOI: 10.1021/acs.biomac.4c01377

Hidetoshi Teramoto, Yoshimi Amano, Katsura Kojima, Masatoshi Iga, Kensaku Sakamoto

引用次数: 0

Multifunctions of Sustainable Chondroitin Sulfates with Predominant Subtypes and Low Molecular Weights on Neurite Outgrowth. 具有优势亚型和低分子量的可持续硫酸软骨素对神经突生长的多功能作用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-21 DOI: 10.1021/acs.biomac.4c01713

Shuqin Xu, Meiling Qiu, Liyuan Liang, Yue Chen, Yajia Wang, Jing Wu, Jinghua Chen

{"title":"Multifunctions of Sustainable Chondroitin Sulfates with Predominant Subtypes and Low Molecular Weights on Neurite Outgrowth.","authors":"Shuqin Xu, Meiling Qiu, Liyuan Liang, Yue Chen, Yajia Wang, Jing Wu, Jinghua Chen","doi":"10.1021/acs.biomac.4c01713","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01713","url":null,"abstract":"Three chondroitin sulfate (CS) analogues with predominant subtypes (A, C, and E) were prepared from engineered Escherichia coli K4 combined with regioselective sulfation. CS with the designed sulfates as the main components was characterized by nuclear magnetic resonance spectroscopy, elementary analysis, and disaccharide analysis. CS prepared from the native or degraded capsular polysaccharide had molecular weights of 1.55 × 104-1.90 × 104 and 5.6 × 103-7.4 × 103, respectively. We found that CS with dual sulfates promoted the outgrowth and survival of hippocampal neurons, whereas CS with monosulfate had an inhibitory effect. CS interacted with the nerve growth factor (NGF) and tyrosine kinase (TrkA), which activated the extracellular signal-regulated kinase (ERK) signaling pathway to modulate the outgrowth of hippocampal neurons. This work clarified the multiple effects of CS on neurite outgrowth based on nonanimal-sourced glycosaminoglycans, which would benefit efforts in discovering their novel functions and therapeutic applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair. 通过坚固的润滑核壳纳米纤维抑制摩擦诱导的外源性粘连用于高质量肌腱修复。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-19 DOI: 10.1021/acs.biomac.4c01729

Xin Cao, Jinghua Li, Weijie Zhai, Bowen Zhou, Hao Lin, Yi Wang

{"title":"Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair.","authors":"Xin Cao, Jinghua Li, Weijie Zhai, Bowen Zhou, Hao Lin, Yi Wang","doi":"10.1021/acs.biomac.4c01729","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01729","url":null,"abstract":"Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM). The L/R-NM shell featured a robust coating of the zwitterionic PMPC polymer for strong hydration lubrication to resist exogenous healing. The core could achieve sustained platelet-rich plasma release to promote endogenous healing. Friction tests and cell experiments confirmed L/R-NM's prominent lubricating properties and antiadhesive performance in vitro. Rat tendon injury model evaluation indicated that L/R-NM effectively promotes high-quality tendon repair by inhibiting friction-induced exogenous adhesion and promoting endogenous healing. Therefore, we believe that L/R-NM will open a unique novel horizon for tendon repair.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Enzyme-Responsive Biodegradable Poly(propylene fumarate) and Polycaprolactone Polyphosphoester Dendrimer Cross-Linked via Click Chemistry for Bone Tissue Engineering. 骨酶反应-可生物降解聚（富马酸丙烯）和聚己内酯聚磷酸酯树状大分子通过点击化学交联用于骨组织工程。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-16 DOI: 10.1021/acs.biomac.4c00999

Xifeng Liu, Areonna C Schreiber, Maria D Astudillo Potes, Babak Dashtdar, Abdelrahman M Hamouda, Asghar Rezaei, Benjamin D Elder, Lichun Lu

{"title":"Bone Enzyme-Responsive Biodegradable Poly(propylene fumarate) and Polycaprolactone Polyphosphoester Dendrimer Cross-Linked via Click Chemistry for Bone Tissue Engineering.","authors":"Xifeng Liu, Areonna C Schreiber, Maria D Astudillo Potes, Babak Dashtdar, Abdelrahman M Hamouda, Asghar Rezaei, Benjamin D Elder, Lichun Lu","doi":"10.1021/acs.biomac.4c00999","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00999","url":null,"abstract":"Traditional polymer systems often rely on toxic initiators or catalysts for cross-linking, posing significant safety risks. For bone tissue engineering, another issue is that the scaffolds often take a longer time to degrade, inconsistent with bone formation pace. Here, we developed an enzyme-responsive biodegradable poly(propylene fumarate) (PPF) and polycaprolactone (PCL) polyphosphoester (PPE) dendrimer cross-linked utilizing click chemistry (EnzDeg-click-PFCLPE scaffold) for enhanced biocompatibility and degradation. The strain-promoted alkyne-azide cycloaddition (SPAAC) offers high efficiency and biocompatibility without harmful agents. The polyphosphoesters render polymer cleavage responsive to alkaline phosphatase (ALP) enzyme in bone formation, ensuring facilitated scaffold biodegradation. The in vitro testing confirmed biocompatibility, enzyme-responsive degradation, and capability to support stem cell differentiation. Further in vivo implantation in rat demonstrated bone regeneration and scaffold integration. In summary, this polymer system combining click chemistry with ALP-responsive biodegradation ensures initial bone support and facilitates scaffold degradation synchronized with the natural bone healing process.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycarbonate-Based Polymersome Photosensitizers with Cell-Penetrating Properties for Improved Killing of Cancer Cells. 具有细胞穿透性能的聚碳酸酯基聚合体光敏剂用于提高癌细胞杀伤能力。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-15 DOI: 10.1021/acs.biomac.4c01571

Suzhen Wang, Zhezhe Li, Lili Zhao, Yuerong Lin, Hailong Che

{"title":"Polycarbonate-Based Polymersome Photosensitizers with Cell-Penetrating Properties for Improved Killing of Cancer Cells.","authors":"Suzhen Wang, Zhezhe Li, Lili Zhao, Yuerong Lin, Hailong Che","doi":"10.1021/acs.biomac.4c01571","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01571","url":null,"abstract":"Polymer-based photosensitizers have found various applications in photodynamic therapy (PDT). However, the absence of targeting ability commonly results in a substantial reduction in photosensitizer accumulation at the tumor site, significantly limiting the therapeutic efficacy of the system. In addition, the development of biodegradable polymeric photosensitizers is of critical importance for biological applications. In this work, we present the development of guanidine-functionalized biodegradable photosensitizers based on poly(trimethylene carbonate) (PTMC) block copolymers, which can self-assemble into polymersomes. The presence of guanidine groups on the surface of polymersomes can significantly enhance the cellular uptake efficiency of photosensitizers, thereby improving the intracellular production of reactive oxygen species (ROS). The in vitro study demonstrates that the guanidinylated polymersome photosensitizers can promote the killing of cancer cells compared to unfunctionalized polymersomes in the presence of light irradiation. The guanidine-functionalized PTMC-based polymersome photosensitizers, with the integration of cell-targeting ability and biodegradability, are anticipated to provide a novel strategy for developing advanced biomedical polymer systems for PDT.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Treatment of Polyamide 6 through Enzymatic Hydrolysis and Covalent Incorporation of Chitosan Nanoparticles. 酶解与壳聚糖纳米颗粒共价结合对聚酰胺6的表面处理。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-15 DOI: 10.1021/acs.biomac.4c01281

Larissa Paza, Wendhy C Vicente, Marília Miotto, Marcel Afonso Provenzi, Daniane Aparecida Netzel, Larissa N Carli, Patrícia B Brondani

{"title":"Surface Treatment of Polyamide 6 through Enzymatic Hydrolysis and Covalent Incorporation of Chitosan Nanoparticles.","authors":"Larissa Paza, Wendhy C Vicente, Marília Miotto, Marcel Afonso Provenzi, Daniane Aparecida Netzel, Larissa N Carli, Patrícia B Brondani","doi":"10.1021/acs.biomac.4c01281","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01281","url":null,"abstract":"Polyamide (PA) has notable physical and chemical properties and is one of the most versatile synthetic materials in the industrial sector. However, its hydrophobicity creates significant challenges in its beneficiation and modification. Modifications of PA with chitosan nanoparticles (CNPs) can improve its undesired properties but are rarely found in the literature due to the weak interaction between the chemical groups of both structures. Surface hydrolysis mediated by enzymes can mildly improve the PA properties and create reactive sites. These sites can react with CNPs to confer enhanced properties to the fabrics, such as antimicrobial activity and flame retardancy. This study investigated the action of 14 hydrolases in the surface hydrolysis of 100% polyamide 6 (PA 6) fabric. Such an extensive study applying several enzymes for this process is uncommon. Under the optimum conditions, the hydrolyzed fabric was covalently bonded to the CNPs, generating material with reduced bacterial proliferation and flame retardancy properties. The uncommon covalent bond attachment achieved high material durability, even after five washing cycles.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142996230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0