Biomacromolecules最新文献_第3页

Sustainable Hybrid Latexes Derived from Starch Bioparticles and Biobased Monomers. 由淀粉生物颗粒和生物基单体衍生的可持续杂交乳胶。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-29 DOI: 10.1021/acs.biomac.5c01315

Sofía F Cabrera, Aitor Barquero, Ludmila I Ronco, Sara Beldarrain, Luis M Gugliotta, Roque J Minari, Jose R Leiza

{"title":"Sustainable Hybrid Latexes Derived from Starch Bioparticles and Biobased Monomers.","authors":"Sofía F Cabrera, Aitor Barquero, Ludmila I Ronco, Sara Beldarrain, Luis M Gugliotta, Roque J Minari, Jose R Leiza","doi":"10.1021/acs.biomac.5c01315","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01315","url":null,"abstract":"Starch is a widely available biopolymer with the potential to replace petroleum-based acrylic monomers in coating binders, but its hydrophilicity and water sensitivity limit its incorporation. This study enhances biobased content in hybrid latexes by simultaneously incorporating starch/zein bioparticles (BPs), produced via nanoprecipitation, and commercial biobased monomers including 2-octyl acrylate, 2-octyl methacrylate, and isobornyl methacrylate. Waterborne hybrid dispersions were synthesized through semibatch emulsion polymerization, using BPs as seeds with variable biobased formulations. The influence of solids content, increased from 20% to 32%, was also examined. The resulting hybrid latexes achieved biobased contents exceeding 70% and demonstrated excellent film-forming properties. When applied in paint formulations, they yielded stable coatings with high surface hydrophobicity (contact angle of 98°) and good coverage. These findings demonstrate the potential of combining starch-based bioparticles with bioderived monomers to create sustainable waterborne coatings with high biobased content and competitive performance.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased Expression of Bacterial Cellulose Synthase Genes in Komagataeibacter Xylinus Exposed to a Rotating Magnetic Field. 旋转磁场作用下木林komagataeibacterium Xylinus细菌纤维素合酶基因表达的增加

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-29 DOI: 10.1021/acs.biomac.5c00653

Anna Zywicka, Aleksandra Dunisławska, Karol Fijalkowski

引用次数: 0

Retraction of “Light-Triggered Cross-Linking of Linear Poly(ethylene glycol) Hydrogels for Enhanced Antibacterial Delivery” “光触发交联线性聚乙二醇水凝胶增强抗菌递送”的撤回。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-28 DOI: 10.1021/acs.biomac.5c01318

Siyuan Liu, Yuan Tian, Kaijie Zhao, Peiyu Zhang*, Jia Li* and Jiwei Cui*,

引用次数: 0

Molecular Crosstalk between Artificial Sweetener Aspartame and Diabetes-Linked Insulin Hormone Unveils Possible Amyloidosis Risks. 人工甜味剂阿斯巴甜和糖尿病相关胰岛素激素之间的分子串扰揭示了可能的淀粉样变风险。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-28 DOI: 10.1021/acs.biomac.5c00286

Masihuzzaman Ansari, Kailash Prasad Prajapati, Shikha Mittal, Vaishali Bhati, Vartika Gupta, Shraddha Mishra, Swati Patidar, Om Prakash Mahato, Aurgha Kamal Bhandari, Bibin Gnanadhason Anand, Karunakar Kar

{"title":"Molecular Crosstalk between Artificial Sweetener Aspartame and Diabetes-Linked Insulin Hormone Unveils Possible Amyloidosis Risks.","authors":"Masihuzzaman Ansari, Kailash Prasad Prajapati, Shikha Mittal, Vaishali Bhati, Vartika Gupta, Shraddha Mishra, Swati Patidar, Om Prakash Mahato, Aurgha Kamal Bhandari, Bibin Gnanadhason Anand, Karunakar Kar","doi":"10.1021/acs.biomac.5c00286","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00286","url":null,"abstract":"An important adaptation for diabetes patients is the consumption of artificial sweetener aspartame, which is present in more than thousands of food products and medicines. Several studies have shown diverse side effects of aspartame, and it is also known to form amyloid-like cytotoxic and cross-seeding-competent nanostructures. Here, we reveal a direct crosstalk between aspartame and insulin that induces their cross-seeding and coaggregation events. Insulin's cross-β structure possesses high affinity for aspartame and triggers its self-assembly into cytotoxic nanostructures. Likewise, aspartame nanostructures were found to trigger the amyloid aggregation of insulin. The coaggregates of aspartame and insulin display amyloid-like structural and biophysical characteristics, and possess potential to initiate cross-seeding reactions. Importantly, unlike insulin fibrils, the aspartame-insulin coassembled fibrils were found to be peptidase-resistant and cytotoxic. The results indicate the interplay between insulin fibrillation and aspartame aggregation, which signifies a possible link between the progression of diabetes-associated complications and the consumption of aspartame.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Chitin/Protein Nanofibrils Isolated from Crab Shell As a Green Platform Constructing a Hydrogel/Aerogel for Environmental Remediation 从蟹壳中分离天然几丁质/蛋白纳米原纤维构建环境修复水凝胶/气凝胶绿色平台

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-27 DOI: 10.1021/acs.biomac.5c00416

Liang Liu*, Yi Qin, Rui Zhou and Yimin Fan*,

{"title":"Natural Chitin/Protein Nanofibrils Isolated from Crab Shell As a Green Platform Constructing a Hydrogel/Aerogel for Environmental Remediation","authors":"Liang Liu*, Yi Qin, Rui Zhou and Yimin Fan*, ","doi":"10.1021/acs.biomac.5c00416","DOIUrl":"10.1021/acs.biomac.5c00416","url":null,"abstract":"Chitin/protein nanofibrils are extracted from decalcified crab shells using 100 mM hydrochloric acid and ultrasonication or high-pressure homogenization, achieving a 94% recovery rate. Further increases in the temperature or duration enhance hydrolysis, leading to a significant reduction in the nanofibril size. The increase in the number of acidic amino acids within the nanofibrils enhances electrostatic repulsion, promoting their dispersion under acidic conditions. This unique dispersibility enables the use of acidic/alkaline gas phase coagulation and ice-templated cross-linking for hydrogel construction. The protein content is believed to support efficient cross-linking between formaldehyde and the nanofibrils, resulting in aerogels that exhibit excellent adsorption properties, with capacities of 840.0 ± 84.2 g/g for water, 168.8 ± 8.9 g/g for pump oil, and 183.1 ± 2.6 g/g for cinnamon oil. The methodology utilized in this study demonstrates enhanced economic viability and simplicity compared with previously reported aerogels, showing significant potential for more practical and widespread applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"5670–5679"},"PeriodicalIF":5.4,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral Supplementation of Medium-Molecular-Weight Hyaluronic Acid (200–600 kDa) As a Functional Food Ingredient Alleviates D-Galactose-Induced Skin Aging 口服中分子量透明质酸（200-600 kDa）可减轻d -半乳糖引起的皮肤老化。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-26 DOI: 10.1021/acs.biomac.5c00935

Shuyu Guo, Botao Wang, Bingyong Mao, Tianmeng Zhang, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen and Shumao Cui*,

{"title":"Oral Supplementation of Medium-Molecular-Weight Hyaluronic Acid (200–600 kDa) As a Functional Food Ingredient Alleviates D-Galactose-Induced Skin Aging","authors":"Shuyu Guo, Botao Wang, Bingyong Mao, Tianmeng Zhang, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Wei Chen and Shumao Cui*, ","doi":"10.1021/acs.biomac.5c00935","DOIUrl":"10.1021/acs.biomac.5c00935","url":null,"abstract":"Hyaluronic acid (HA), a functional food ingredient with multitarget biological activities, shows potential in combating age-related disorders. HA levels in skin cells may serve as potential biomarkers for aging and decrease with age. This study first investigated the antiaging efficacy of oral supplementation with HA with different molecular weights (MWs) (2, 30–50, 80–100, 200–600, and 1000 kDa) in a D-galactose-induced aging mouse model. Comparative analysis revealed that 200–600 kDa HA exhibited superior performance in maintaining skin moisture, elasticity, and antifatigue properties. Concomitantly, it significantly increased the amount of HA in the tissues (serum, eyes, skin, and joints) of aging mice. And, it can significantly regulate the diversity and composition of microbial communities. Further analysis of different HA concentrations (low, medium, and high concentrations) of 200–600 kDa revealed that the medium concentration was most effective in alleviating skin aging. This study presents a novel approach to safety utilizing HA for the alleviation of skin aging.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"6015–6027"},"PeriodicalIF":5.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan/Trametes versicolor Laccase Nanostructures with Modulated Catalytic Activity 具有调节催化活性的壳聚糖/彩壳聚糖漆酶纳米结构。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-26 DOI: 10.1021/acs.biomac.5c01217

Larisa-Maria Petrila, Timeea-Anastasia Ciobanu, Tudor Vasiliu, Stergios Pispas* and Marcela Mihai*,

{"title":"Chitosan/Trametes versicolor Laccase Nanostructures with Modulated Catalytic Activity","authors":"Larisa-Maria Petrila, Timeea-Anastasia Ciobanu, Tudor Vasiliu, Stergios Pispas* and Marcela Mihai*, ","doi":"10.1021/acs.biomac.5c01217","DOIUrl":"10.1021/acs.biomac.5c01217","url":null,"abstract":"Polymer/enzyme nanoassemblies are a class of nanomaterials of increasing interest for the medical, industrial, or environmental fields. This study comprises a thorough scrutiny of the formation of nanoassemblies between Trametes versicolor laccase and a polysaccharide, chitosan, employing various experimental and theoretical methods. The binding mechanism was investigated through fluorescence quenching and molecular dynamics simulations, which identified key amino acids involved in the interaction. Modifications in the local environment of key fluorophores in the enzyme structure were detected using fluorescence spectroscopy, and the binding constant, number of binding sites, and quenching mechanism were assessed. At the same time, the nanoassemblies formation was confirmed by dynamic and electrophoretic light scattering, providing information on their size, polydispersity, surface charge, and stability. The catalytic activity of the formed nanoassemblies was assessed under various conditions by ABTS oxidation and by Indigo Carmine degradation tests. The obtained nanoassemblies exhibited enhanced stability in various experimental conditions (pH, temperature, storage) related to their catalytic activity.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"6244–6257"},"PeriodicalIF":5.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dielectric Characterization of Protonated Chitosan-Lignin Biocomposite Membranes: Influence of Chitosan and Lignin Types 质子化壳聚糖-木质素生物复合膜的介电特性：壳聚糖和木质素类型的影响。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-26 DOI: 10.1021/acs.biomac.5c01090

Mark H. Wolf, Nagore Izaguirre, Jalel Labidi and Amparo Ribes-Greus*,

{"title":"Dielectric Characterization of Protonated Chitosan-Lignin Biocomposite Membranes: Influence of Chitosan and Lignin Types","authors":"Mark H. Wolf, Nagore Izaguirre, Jalel Labidi and Amparo Ribes-Greus*, ","doi":"10.1021/acs.biomac.5c01090","DOIUrl":"10.1021/acs.biomac.5c01090","url":null,"abstract":"Biobased chitosan-lignin composite membranes with tailored dielectric and conductive properties were developed using chitosan of high (CSH) and low (CSL) molecular weight and degree of deacetylation, combined with kraft (KL) and organosolv lignin (OL) as fillers. The membranes were protonated by immersion in 1.0 M sulfuric acid. CSH composites exhibit stronger ionic interactions with sulfate groups compared to CSL composites, resulting in a dense structure that hinders water absorption and increases fragility. Chitosan interactions with sulfuric acid and lignin restrict the mobility of dielectric relaxations, with KL having a more pronounced effect than OL due to its smaller size and higher phenolic OH content. The membranes act as electrical insulators, exhibiting electron conductivities ranging from 10–15 to 10–8 S/cm between −10 and 170 °C, and proton conductivities between 2.9 × 10–3 and 4.4 × 10–3 S/cm at 60 °C. These properties make them promising candidates for use as biobased electrolytes in fuel cell applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"6140–6151"},"PeriodicalIF":5.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c01090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Programmable Injectable Dual-Responsive Hydrogels with NIR Ratiometric Self-Monitoring of pH/Ca2+ for Sensing and Actuation 可编程注射双响应水凝胶与近红外比例自监测pH/Ca2+的传感和驱动。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-26 DOI: 10.1021/acs.biomac.5c01084

Mingning Zhu*, and , Dongdong Lu*,

{"title":"Programmable Injectable Dual-Responsive Hydrogels with NIR Ratiometric Self-Monitoring of pH/Ca2+ for Sensing and Actuation","authors":"Mingning Zhu*,  and , Dongdong Lu*, ","doi":"10.1021/acs.biomac.5c01084","DOIUrl":"10.1021/acs.biomac.5c01084","url":null,"abstract":"Self-monitoring, functional, injectable hydrogels represent an advancement in smart biomaterials. In this study, we developed injectable dual-responsive hydrogel composites with near-infrared (NIR) emission, fabricated from a nonradiative energy transfer (NRET) nanoprobes and doubly cross-linked microgel (DX MG) building blocks. These hydrogels were easily prepared and exhibit reversible responsiveness to both pH (4.5–7.4) and Ca2+ (0.005–0.08 M) through phototriggered covalent cross-linking of low-concentration (∼7 wt %) shear-thinning microgels. The resulting gels demonstrate tunable modulus and swelling ratios in response to environmental pH and Ca2+ levels, which could be reversibly monitored via NIR ratiometric photoluminescence (RMPL). They withstood 90% compression with low hysteresis, enabling NIR-monitored cyclic compression and tissue imaging. A bilayer actuator, combining DX MG with green-emitting polyacrylamide gels, achieved simultaneous pH/Ca2+ response and tortuosity monitoring via NIR RMPL. To the best of our knowledge, this is the first report of a self-monitoring hydrogel actuator utilizing NIR ratiometric photoluminescence, offering significant promise for PL bionic-driven soft matter and biomedical applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"6129–6139"},"PeriodicalIF":5.4,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabricating a Curcumin-Loaded Chitin/Lignin Micelle Thermoresponsive Hydrogel with Dynamic Contractility and Tissue-Adhesive Properties for Enhanced Wound Regeneration 姜黄素负载的几丁质/木质素胶束热响应水凝胶的制备，具有动态收缩性和组织粘附性，用于增强伤口再生。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-08-25 DOI: 10.1021/acs.biomac.5c00603

Yue Zhang, Siyuan Wen, Ke Zheng, Xin Zhou*, Caoxing Huang, Yong Xu, Jing Luo* and Geng Lu*,

{"title":"Fabricating a Curcumin-Loaded Chitin/Lignin Micelle Thermoresponsive Hydrogel with Dynamic Contractility and Tissue-Adhesive Properties for Enhanced Wound Regeneration","authors":"Yue Zhang, Siyuan Wen, Ke Zheng, Xin Zhou*, Caoxing Huang, Yong Xu, Jing Luo* and Geng Lu*, ","doi":"10.1021/acs.biomac.5c00603","DOIUrl":"10.1021/acs.biomac.5c00603","url":null,"abstract":"Skin exhibits limited self-regenerative capacity following an injury; therefore, it is imperative to develop appropriate wound dressings capable of expediting postinjury closure to prevent microbial invasion and enhance the wound healing process. In this study, poly-N-isopropylacrylamide (PNI), sodium dodecyl sulfate/octadecyl methacrylate micellar (SA), and micellar (chitin/lignin)-loaded curcumin (Cur) were used for constructing a thermosensitive and tissue-adhesive hydrogel (PNI-SA@Cur), aiming to develop a wound dressing that enhanced wound healing. The results demonstrated that PNI-SA@Cur hydrogel exhibited superior thermal shrinkability, along with excellent adhesion and self-healing capabilities, and it also showed good hemocompatibility and cytocompatibility. Additionally, PNI-SA@Cur as a sealant significantly achieved suture-free postwound closure in the early stages of wound healing, and it demonstrated a substantial capacity to promote wound healing by reducing inflammatory cell infiltration, facilitating favorable collagen deposition, and stimulating abundant angiogenesis. The thermoresponsive and tissue-adhesive hydrogel dressing represents a promising material for promoting wound healing.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 9","pages":"5778–5790"},"PeriodicalIF":5.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144935787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0