BiomacromoleculesPub Date : 2025-07-15DOI: 10.1021/acs.biomac.5c00849
Ahmad Mirkani, Mohammad Reza Nabid, Sarvenaz Pakian
{"title":"Microfluidics-Facilitated Synthesis of Methacrylated Chitosan-Coated Liposomes: An Innovative Platform for Prolonged Ocular Retention and Controlled Drug Release.","authors":"Ahmad Mirkani, Mohammad Reza Nabid, Sarvenaz Pakian","doi":"10.1021/acs.biomac.5c00849","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00849","url":null,"abstract":"<p><p>This study presents methacrylated chitosan-coated liposomes (CSMA-liposomes) as an innovative ocular drug delivery technology to tackle the issue of rapid drug removal from the eye. Liposomes synthesized via microfluidic techniques were coated with CSMA to enhance mucoadhesion and prolong residence time through electrostatic and covalent interactions with mucin. Liposomal optimization produced uncoated liposomes measuring 154 nm with a PDI of 0.12, which rose to 208 nm following CSMA coating. The zeta potential shifted from -8.3 to +36 mV, indicating effective functionalization. In vitro, CSMA-liposomes exhibited significant mucoadhesion, resulting in a particle size increase to 369 nm and a zeta potential of +2.4 mV after 4 h of incubation with mucin. Ex vivo retention on bovine conjunctival tissues exhibited enhanced fluorescence retention of CSMA-liposomes relative to untreated and chitosan-coated liposomes. The release of dexamethasone sodium phosphate from CSMA-liposomes demonstrated a sustained, biphasic profile, indicating potential for improved ocular bioavailability and therapeutic effectiveness.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144641234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-15DOI: 10.1021/acs.biomac.5c00765
Brenden P Wheeler, Kyle Medd, Kaitlyn E Woodworth, Locke Davenport Huyer
{"title":"Molecular and Macroscopic Considerations for Degradable Aliphatic Polyester Biomaterial Design.","authors":"Brenden P Wheeler, Kyle Medd, Kaitlyn E Woodworth, Locke Davenport Huyer","doi":"10.1021/acs.biomac.5c00765","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00765","url":null,"abstract":"<p><p>Degradable aliphatic polyesters (DAPs) are integral materials for the design of resorbable medical devices including resorbable sutures, drug delivery depots, and temporary tissue growth supports. The clinical application of DAPs is due to their ability to resorb over a therapeutic window. Control over resorption rates is defined by material properties, which inform the selection of a formulation for specific applications. This review examines the synthesis and degradation behavior of DAPs for biomedical applications. We focus on copolymer DAPs, which offer promising opportunities to tailor resorption by strategically incorporating diverse α,ω-dicarboxylic acid and α,ω-diol monomers. We analyze the molecular and macroscopic factors influencing hydrolytic degradation, correlating these to the copolymer composition. We highlight emerging approaches for assessing degradation behavior through efficient techniques and real-time monitoring capabilities. Material property-informed DAP innovation offers a strategy for improved resorbable device performance tailored for specific biomedical applications.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144635724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-14DOI: 10.1021/acs.biomac.5c00340
Sol Ji Park, Seo Hyung Moon, Bum Jun Jang, Sang Hyun Lee, Hwa Sung Shin, Yun Jung Yang
{"title":"Sustainable Encapsulation of <i>Bacillus velezensis</i> FZB42 Using Tunicate-Derived Carboxymethylcellulose Hydrogels for Enhanced Biocontrol Efficiency.","authors":"Sol Ji Park, Seo Hyung Moon, Bum Jun Jang, Sang Hyun Lee, Hwa Sung Shin, Yun Jung Yang","doi":"10.1021/acs.biomac.5c00340","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00340","url":null,"abstract":"<p><p>The excessive use of chemical fertilizers and pesticides has led to increasing environmental pollution and biodiversity loss, accelerating the emergence of resistant phytopathogens. As an alternative, biological control agents offer a sustainable approach; however, their efficacy is often limited due to poor stability under varying environmental conditions, underscoring the need for improved formulation strategies. In this study, a pH-responsive hydrogel system was designed by combining tunicate-derived carboxymethylcellulose (TCMC) with alginate to encapsulate spores of the biocontrol bacterium <i>Bacillus velezensis</i> FZB42. The resulting TCMC hydrogel demonstrated controlled spore release under alkaline conditions and enhanced mechanical strength and thermal stability. These properties effectively suppressed alkaline-favoring fungal pathogens, such as <i>Fusarium graminearum</i>, in vitro assays. Beyond its functional performance, the system provides an environmentally conscious solution by repurposing discarded tunicate shells, a major marine waste byproduct. Overall, this platform supports the long-term stabilization and delivery of microbial agents while promoting sustainable agricultural practices and marine biowaste valorization.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144624983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-14Epub Date: 2025-06-23DOI: 10.1021/acs.biomac.5c00275
Qing Huang, Xiaonuo Hu, Xinyu Fan, Yuchen Li, Ming Wei, Xinning Li, Kecen Liu, Zihan Lin, Yi Li, Zhaoming Dong, Ping Zhao, Qingyou Xia, Xin Wang
{"title":"Longer Duct, Better Silk: Unveiling How Anterior Silk Gland Length Boosts Fiber Performance.","authors":"Qing Huang, Xiaonuo Hu, Xinyu Fan, Yuchen Li, Ming Wei, Xinning Li, Kecen Liu, Zihan Lin, Yi Li, Zhaoming Dong, Ping Zhao, Qingyou Xia, Xin Wang","doi":"10.1021/acs.biomac.5c00275","DOIUrl":"10.1021/acs.biomac.5c00275","url":null,"abstract":"<p><p>The mechanical performance of silk is closely tied to the fibrillization process within the anterior segment of silk gland (ASG). While a long and narrow ASG is conserved across silk-spinning species, its biological role remains unclear. Here, we performed a comprehensive structure-function analysis of the silkworm ASG and revealed that its long and narrow morphology plays an essential role in silk fibrillization and fiber performance. A steep reduction in duct diameter at the ASG's onset initiates silk protein transformation, while the extended duct length promotes molecular alignment, crystallization, and orientation. Genetic manipulation to extend ASG length significantly increased the Young's modulus and toughness of silkworm silk fibers. These findings demonstrate the potential of ASG length modulation as an effective strategy to improve silk fiber performance and provide valuable insights into the biological and functional importance of silk gland morphology.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"4262-4273"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sucheta Chatterjee*, Mrityunjay Tyagi, Ayan Ghosh, Pallavi Chandwadkar, Suryakant Nagar, Jaideep Mor, Amey P. Wadawale, Celin Acharya, Birija S. Patro and Dibakar Goswami*,
{"title":"","authors":"Sucheta Chatterjee*, Mrityunjay Tyagi, Ayan Ghosh, Pallavi Chandwadkar, Suryakant Nagar, Jaideep Mor, Amey P. Wadawale, Celin Acharya, Birija S. Patro and Dibakar Goswami*, ","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00316","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BiomacromoleculesPub Date : 2025-07-14DOI: 10.1021/acs.biomac.5c00145
Andrew Singh, Nate Dowdall, Todd Hoare
{"title":"Poly(Oligo(Ethylene Glycol) Methacrylate)-Based Polymers in Biomedical Applications: Preparation and Applications","authors":"Andrew Singh, Nate Dowdall, Todd Hoare","doi":"10.1021/acs.biomac.5c00145","DOIUrl":"10.1021/acs.biomac.5c00145","url":null,"abstract":"<div><div>While poly(ethylene glycol) (PEG) has been widely applied in a host of biomedical applications due to its antifouling properties, its limited potential for functionalization and emerging concerns over potential immunogenicity have inspired the development of PEG alternatives. Herein, we review the use of poly(oligo(ethylene glycol) methacrylate) (POEGMA) as a PEG alternative that can provide significantly more synthetic versatility, minimize immunogenicity, and open up additional applications (e.g., thermoresponsive devices) based on precise control over the (co)polymer composition, the backbone molecular weight, and the side chain molecular weight. The synthetic pathways and applications of POEGMA as a surface or biomolecular grafting agent, a hydrogel, a microgel/nanogel, and a nanoparticle stabilizer are comprehensively summarized, with applications in drug delivery, tissue engineering/wound healing, and biosensing particularly highlighted to show how the unique properties of POEGMA can impart improved or unique application performance. Future directions to better leverage the properties of POEGMA in diverse applications are also proposed.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (59KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 3929-3973"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}