Biomacromolecules最新文献_第4页

A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing. 介孔氧化锌和重组人胶原蛋白时空给药的多功能复合水凝胶，用于糖尿病感染伤口愈合。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-21 DOI: 10.1021/acs.biomac.4c01155

Ye Wu, Cheng Hu, Yaxing Li, Yu Wang, Heng Gong, Cheng Zheng, Qing-Quan Kong, Li Yang, Yunbing Wang

{"title":"A Versatile Composite Hydrogel with Spatiotemporal Drug Delivery of Mesoporous ZnO and Recombinant Human Collagen for Diabetic Infected Wound Healing.","authors":"Ye Wu, Cheng Hu, Yaxing Li, Yu Wang, Heng Gong, Cheng Zheng, Qing-Quan Kong, Li Yang, Yunbing Wang","doi":"10.1021/acs.biomac.4c01155","DOIUrl":"10.1021/acs.biomac.4c01155","url":null,"abstract":"Diabetic wounds are increasingly common and challenging to treat due to high infection risks in a high-glucose environment. Effective treatment requires wound dressings that combat infections, while promoting angiogenesis and skin regeneration. This study presents a hydrogel-based drug delivery system made from cellulose designed to accelerate diabetic wound healing by eliminating bacterial infections. The hydrogel, formed by linking phenylboronic acid-grafted oxidized methylcellulose (POMC) with poly(vinyl alcohol) (PVA), exhibits self-healing and injectable properties. It is further enhanced by adding type I recombinant human collagen (rhCOL1) to stimulate cell growth and angiogenesis and mesoporous zinc oxide (mZnO) for antibacterial and anti-inflammatory effects. Upon application, the hydrogel degrades under pH/ROS stimuli, releasing mZnO and rhCOL1 in a controlled manner that matches the wound healing stages. In vivo tests show that the hydrogel effectively eliminates bacteria, reduces inflammation, and promotes rapid skin regeneration, making it a promising solution for treating diabetic wounds.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7878-7893"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and Enhanced Flexibility of Starch-Based Cross-Linked Films. 淀粉基交联薄膜的制作与柔韧性增强

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-06 DOI: 10.1021/acs.biomac.4c01172

Ji-Hyun Cho, Kwang-Hyun Ryu, Hyun-Joong Kim, Jong-Ho Back

{"title":"Fabrication and Enhanced Flexibility of Starch-Based Cross-Linked Films.","authors":"Ji-Hyun Cho, Kwang-Hyun Ryu, Hyun-Joong Kim, Jong-Ho Back","doi":"10.1021/acs.biomac.4c01172","DOIUrl":"10.1021/acs.biomac.4c01172","url":null,"abstract":"The development of sustainable materials has driven significant interest in starch as a renewable and biodegradable polymer. However, the inherent brittleness, hydrophilicity, and lack of thermoplasticity of native starch limit its application in material science. This study addresses the limitations of native starch by converting it to dialdehyde starch (DAS) and cross-linking with polyether diamines via imine bonds. The effects of Jeffamine molecular weights (D-2000, D-400, and D-230) and mole ratios on the mechanical, thermal, and structural properties of starch-based films were examined. The cross-linked DAS/Js films exhibited significant enhancements in flexibility and toughness. Specifically, DAS/J2000 at a 0.03 mol ratio achieved a tensile strength of 62.9 MPa. In comparison, DAS/J400 at a 0.5 mol ratio demonstrated 126.2% elongation at break, indicating the balance between cross-linking density and chain mobility. X-ray diffraction (XRD) analysis revealed reduced crystallinity and tighter molecular packing with increased cross-linking. Dynamic mechanical analysis (DMA) indicated a decrease in Tg with an increasing mole ratio, reflecting enhanced molecular mobility. The results underscore the potential of optimized cross-linking conditions to produce starch-based films with properties that contribute to developing sustainable biopolymer materials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7894-7903"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gelation during Ring-Opening Reactions of Cellulosics with Cyclic Anhydrides: Phenomena and Mechanisms. 纤维素与环状酸酐开环反应过程中的凝胶化：现象与机理。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-21 DOI: 10.1021/acs.biomac.4c01081

Stella P Petrova, Zhaoxi Zheng, Daniel Alves Heinze, Valerie Vaissier Welborn, Michael J Bortner, Klaus Schmidt-Rohr, Kevin J Edgar

{"title":"Gelation during Ring-Opening Reactions of Cellulosics with Cyclic Anhydrides: Phenomena and Mechanisms.","authors":"Stella P Petrova, Zhaoxi Zheng, Daniel Alves Heinze, Valerie Vaissier Welborn, Michael J Bortner, Klaus Schmidt-Rohr, Kevin J Edgar","doi":"10.1021/acs.biomac.4c01081","DOIUrl":"10.1021/acs.biomac.4c01081","url":null,"abstract":"Cellulose esters are used in Food and Drug Administration-approved oral formulations, including in amorphous solid dispersions (ASDs). Some bear substituents with terminal carboxyl moieties (e.g., hydroxypropyl methyl cellulose acetate succinate (HPMCAS)); these ω-carboxy ester substituents enhance interactions with drug molecules in solid and solution phases and enable pH-responsive drug release. However, the synthesis of carboxyl-pendent cellulose esters is challenging, partly due to competing reactions between introduced carboxyl groups and residual hydroxyls on different chains, forming either physically or covalently cross-linked systems. As we explored ring-opening reactions of cyclic anhydrides with cellulose and its esters to prepare polymers designed for high ASD performance, we became concerned upon encountering gelation. Herein, we probe the complexity of such ring-opening reactions in detail, for the first time, utilizing rheometry and solid-state 13C NMR spectroscopy. Gelation in these ring-opening reactions was caused predominantly by physical interactions, progressing in some cases to covalent cross-links over time.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7777-7787"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142685404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Borax Cross-Linked Acrylamide-Grafted Starch Self-Healing Hydrogels. 硼砂交联丙烯酰胺接枝淀粉自愈合水凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-25 DOI: 10.1021/acs.biomac.4c01287

Kai Lu, Xiaohong Lan, Rudy Folkersma, Vincent S D Voet, Katja Loos

{"title":"Borax Cross-Linked Acrylamide-Grafted Starch Self-Healing Hydrogels.","authors":"Kai Lu, Xiaohong Lan, Rudy Folkersma, Vincent S D Voet, Katja Loos","doi":"10.1021/acs.biomac.4c01287","DOIUrl":"10.1021/acs.biomac.4c01287","url":null,"abstract":"The biocompatibility and renewability of starch-based hydrogels have made them popular for applications across various sectors. Their tendency to incur damage after repeated use limits their effectiveness in practical applications. Improving the mechanical properties and self-healing of hydrogels simultaneously remains a challenge. This study introduces a new self-healing hydrogel, synthesized by grafting acrylamide onto starch using ceric ammonium nitrate (CAN) as an initiator, followed by borax cross-linking. We systematically examined how the starch-to-monomer ratio, borax concentration, and CAN concentration impact the grafting reactions and overall performance of the hydrogels. The addition of borax significantly reinforced the strength of the hydrogel; the maximum storage modulus increased by 1.8 times. Thanks to dynamic borate ester and hydrogen bonding, the hydrogel demonstrated remarkable recovery properties and responsiveness to temperature. We expect that the present research could broaden the application of starch-based hydrogels in agriculture, sensors, and wastewater treatment.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"8026-8037"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Powdered Medical Adhesive with Long Lasting Adhesion in Water Environment. 在水环境中具有持久粘性的粉末状医用粘合剂。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-02 DOI: 10.1021/acs.biomac.4c01149

Yi Ju, Junjie Wang, Yang Lei, Yunbing Wang

{"title":"Powdered Medical Adhesive with Long Lasting Adhesion in Water Environment.","authors":"Yi Ju, Junjie Wang, Yang Lei, Yunbing Wang","doi":"10.1021/acs.biomac.4c01149","DOIUrl":"10.1021/acs.biomac.4c01149","url":null,"abstract":"Medical adhesives have been used under surgical conditions. However, it is always a big challenge to maintain long-term adhesion in a water environment. Besides, it usually takes a long time to complete the adhesion, and the operation might be complicated. In this study, tannic acid and gelatin solution under acidic conditions were mixed, flocculated, lyophilized, and crushed; thus, a powdered medical adhesive (POWDER) was prepared with long-lasting adhesion in a water environment, convenience, and low price. Tannic acid bound gelatin and maintained adhesive force primarily through hydrogen bonding and reacted with amino sulfhydryl and other amino acid residues after oxidation into aldehyde, exhibiting excellent underwater adhesion. Oxidized dextran (ODex) powder rich in an aldehyde group was introduced to provide covalent binding in the adhesive. In vitro and in vivo studies showed that POWDER could quickly adhere to various tissues in the water environment. In vitro skin adhesion experiments demonstrated that it could achieve effective adhesion in a water environment for up to 60 days. Its blood compatibility, low cytotoxicity, and biodegradability were also verified. The POWDER developed in this study is of great significance for patients who need rapid wound treatments.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7869-7877"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142563523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adhesive, Stretchable, and Photothermal Antibacterial Hydrogel Dressings for Wound Healing of Infected Skin Burn at Joints. 用于关节感染性皮肤烧伤伤口愈合的粘性、可伸缩和光热抗菌水凝胶敷料。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-14 DOI: 10.1021/acs.biomac.4c01023

Chen Zhang, Hua Zhao, Shanshan Geng, Chenghao Li, Jingmei Liu, Yuxin Chen, Ming Yi, Yuntong Liu, Fangxia Guan, Minghao Yao

引用次数: 0

Understanding the Role of Surface Chemistry in Nanocellulose Kink Formation: A Case Study of TEMPO-Mediated Oxidation. 了解表面化学在纳米纤维素扭结形成中的作用：TEMPO 介导的氧化案例研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-11 DOI: 10.1021/acs.biomac.4c01082

Yixiang Zhen, Chengcheng Peng, Huimin Gao, Liang Bai, Yan Song, Pingping Gao, Yadong Zhao

{"title":"Understanding the Role of Surface Chemistry in Nanocellulose Kink Formation: A Case Study of TEMPO-Mediated Oxidation.","authors":"Yixiang Zhen, Chengcheng Peng, Huimin Gao, Liang Bai, Yan Song, Pingping Gao, Yadong Zhao","doi":"10.1021/acs.biomac.4c01082","DOIUrl":"10.1021/acs.biomac.4c01082","url":null,"abstract":"This study found that the sources of cellulose have a significant effect on the parameters related to the kinks present in nanocellulose. During nanocellulose preparation, 2,2,6,6-tetramethylpiperidinyl-1-oxyl (TEMPO)-mediated oxidation induced partial depolymerization on whole cellulose and made the amorphous regions more susceptible to consequent mechanical treatment irrespective of cellulose sources. However, plant cellulose microfibrils were prone to break into shorter nanocellulose with fewer kinks, while bacterial and tunicate cellulose were more likely to bend rather than break, thus leading to the generation of more kinks. The kinks did not show significant effects on the size, crystallinity index, and thermal properties of nanocellulose for each cellulose source, though the kink numbers were positively related to the mechanical performance of nanocellulose. Collectively, this study elucidated the kink formation mechanisms and clarified the effects of kinks on nanocellulose performance, thus providing new insights into understanding the source and behaviors of microdefects present in nanocellulose.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7767-7776"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Customizable Glycopolymers as Adjuvants for Cancer Immunotherapy: From Branching Degree Optimization to Cell Surface Engineering. 可定制的糖聚合物作为癌症免疫疗法的佐剂：从分支度优化到细胞表面工程。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-13 DOI: 10.1021/acs.biomac.4c01230

Zhichen Zhu, Xingyu Heng, Fangjian Shan, He Yang, Yichen Wang, Hengyuan Zhang, Gaojian Chen, Hong Chen

引用次数: 0

Dendrimer/Copper(II) Complex-Mediated siRNA Delivery Disrupts Lactate Metabolism to Reprogram the Local Immune Microenvironment against Tumor Growth and Metastasis. 树枝状聚合物/铜(II)复合物介导的 siRNA 递送可破坏乳酸代谢，从而重新规划局部免疫微环境，防止肿瘤生长和转移。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-21 DOI: 10.1021/acs.biomac.4c01249

Yue Gao, Aiyu Li, Yanying Li, Honghua Guo, Liangyu He, Kangan Li, Dzmitry Shcharbin, Xiangyang Shi, Mingwu Shen

{"title":"Dendrimer/Copper(II) Complex-Mediated siRNA Delivery Disrupts Lactate Metabolism to Reprogram the Local Immune Microenvironment against Tumor Growth and Metastasis.","authors":"Yue Gao, Aiyu Li, Yanying Li, Honghua Guo, Liangyu He, Kangan Li, Dzmitry Shcharbin, Xiangyang Shi, Mingwu Shen","doi":"10.1021/acs.biomac.4c01249","DOIUrl":"10.1021/acs.biomac.4c01249","url":null,"abstract":"Solid tumors reprogram metabolic pathways to meet their biosynthesis demands, resulting in elevated levels of metabolites in the tumor microenvironment (TME), including lactate. Excessive accumulation and active transportation of lactate within the TME drives tumor progression, metastasis, and immunosuppression. Interruption of TME lactate metabolism is expected to restore antitumor responses and sensitize tumor immunotherapy. Herein, we developed phenylboronic acid- and pyridine-modified poly(amidoamine) dendrimer/copper(II) (Cu(II)) complexes, namely, D-Cu complexes, to deliver monocarboxylate transporter 4 siRNA (siMCT4) and disrupt the tumor lactate shuttle. The D-Cu complexes are shown to have a Cu(II)-mediated chemodynamic effect and T1-weighted magnetic resonance imaging potential (r1 relaxivity = 1.19 mM-1 s-1), enabling effective siMCT4 delivery to inhibit lactate efflux within cancer cells. In combination with a CD11b immune agonist, the treatment of D-Cu/siMCT4 polyplexes in a mouse breast tumor model alleviates local TME immunosuppression, leading to excellent inhibition of both primary tumor growth and lung metastasis.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7995-8005"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biobased Sulfur- and Phosphate-Containing High-Refractive-Index Polymers: Substituent Effects on Optical Properties of Polymers. 含硫和磷的生物基高折射率聚合物：取代基对聚合物光学特性的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-06 DOI: 10.1021/acs.biomac.4c01291

Zongao Dou, Hemin Zhang, Jiajun Li, Jing Sun, Qiang Fang

引用次数: 0