Biomacromolecules最新文献_第4页

Fungal Chitin Nanofibrils Improve Mechanical Performance and UV-Light Resistance in Carboxymethylcellulose and Polyvinylpyrrolidone Films. 真菌甲壳素纳米纤维改善了羧甲基纤维素和聚乙烯吡咯烷酮薄膜的机械性能和抗紫外线性能。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 DOI: 10.1021/acs.biomac.4c00846

Madalen Azpitarte Aretxabaleta, Gotzone Barandika, Rikardo Minguez, Erlantz Lizundia

{"title":"Fungal Chitin Nanofibrils Improve Mechanical Performance and UV-Light Resistance in Carboxymethylcellulose and Polyvinylpyrrolidone Films.","authors":"Madalen Azpitarte Aretxabaleta, Gotzone Barandika, Rikardo Minguez, Erlantz Lizundia","doi":"10.1021/acs.biomac.4c00846","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00846","url":null,"abstract":"Materials from renewable carbon feedstock can limit our dependence on fossil carbon and facilitate the transition from linear carbon-intensive economies to sustainable, circular economies. Chitin nanofibrils (ChNFs) isolated from white mushrooms offer remarkable environmental benefits over conventional crustacean-derived nanochitin. Herein, ChNFs are utilized to reinforce polymers of natural and fossil origin, carboxymethyl cellulose (CMC) and polyvinylpyrrolidone (PVP), respectively. Incorporation of 5 wt % ChNFs increases the Young's modulus from 1217 ± 11 to 1509 ± 22 MPa for PVP and from 1979 ± 48 to 2216 ± 102 MPa for CMC. ChNFs increase surface hydrophobicity and retard the scission of the C-H bond as a result of UV-light irradiation in both polymers under investigation. The yellowing from chain scission is reduced, while long-lasting retention of ductility is ensured. Given these results, we propose the utilization of ChNFs in sustainable polymeric materials from renewable carbon with competitive performance against fossil-based benchmark plastics.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Responsive Nanoparticles for Smart Drug Delivery: A NIR Light-Sensitive and Redox-Reactive PEG-PCL-Based System. 用于智能给药的双响应纳米颗粒：基于近红外光敏和氧化还原反应的 PEG-PCL 系统。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 DOI: 10.1021/acs.biomac.4c00889

Nancy Ferrentino, Taha Behroozi Kohlan, Shokoufeh Mehrtashfar, Anna Finne-Wistrand, Daniela Pappalardo

{"title":"Dual-Responsive Nanoparticles for Smart Drug Delivery: A NIR Light-Sensitive and Redox-Reactive PEG-PCL-Based System.","authors":"Nancy Ferrentino, Taha Behroozi Kohlan, Shokoufeh Mehrtashfar, Anna Finne-Wistrand, Daniela Pappalardo","doi":"10.1021/acs.biomac.4c00889","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c00889","url":null,"abstract":"Stimuli-responsive polymeric nanoparticles (NPs) can serve as smart drug delivery systems (DDSs) by triggering drug release upon external or internal stimuli. A dual-responsive DDS made of a triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-SS-PEG-SS-PCL) copolymer, bearing disulfide bonds between PCL and PEG, was synthesized. The copolymer was functionalized with coumarin and sensitive to near-infrared (NIR) light irradiation, while the S-S bonds could be cleaved by GSH (10 mM). Characterization was achieved by nuclear magnetic resonance, size exclusion chromatography, and Fourier transform infrared analyses. Nile Red (NR)-loaded NPs were prepared through self-assembly of the copolymer in water and analyzed by dynamic light scattering and field-emission scanning electron microscopy. The NR release upon ultraviolet (UV)/NIR light irradiation as well as by GSH concentrations was monitored by using fluorescence spectroscopy, while simultaneous exposure to UV/NIR light and intracellular GSH concentration led to faster NR release. AlamarBlue assay showed satisfactory cell viability of the NR-loaded NPs, while their cellular uptake in human dermal fibroblast cells was investigated by fluorescence microscopy and fluorescence emission measurements.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring LCST- and UCST-like Behavior of Branched Molecules Bearing Repeat Units of Elastin-like Peptides as Side Components. 探索以弹性蛋白样肽重复单元为侧成分的支链分子的 LCST 和 UCST 类行为。

IF 8.3 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-09 DOI: 10.1021/acs.biomac.4c00751

Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, Takeru Nose

{"title":"Exploring LCST- and UCST-like Behavior of Branched Molecules Bearing Repeat Units of Elastin-like Peptides as Side Components.","authors":"Naoki Tanaka, Keitaro Suyama, Keisuke Tomohara, Takeru Nose","doi":"10.1021/acs.biomac.4c00751","DOIUrl":"10.1021/acs.biomac.4c00751","url":null,"abstract":"Elastin-like peptides (ELPs) exhibit lower critical solution temperature (LCST)-type behavior, being soluble at low temperatures and insoluble at high temperatures. While the properties of linear, long-chain ELPs are well-studied, short-chain ELPs, especially those with branched architectures, have been less explored. Herein, to obtain further insights into multimeric short ELPs, we investigated the temperature-responsive properties of branched molecules composed of a repeating pentapeptide unit of short ELPs, Phe-Pro-Gly-Val-Gly, as side components and oligo(Glu) as a backbone structure. In turbidimetry experiments, the branched ELPs showed LCST-like behavior similar to conventional ELPs and upper critical solution temperature (UCST)-like behavior, which are rarely observed in ELPs. In addition, the morphological aspects and mechanisms underlying the temperature-responsiveness were investigated. We observed that spherical aggregates formed, and the branched ELPs underwent structural changes through the self-assembly process. This study demonstrates the unique temperature-responsiveness of branched short ELPs, providing new insights into the future development and use of ELPs with tailored properties.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7156-7166"},"PeriodicalIF":8.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142386382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Silybin-Conjugated Chitosan Polymeric Micelles for Improving the Oral Absorption of Doxorubicin Based on the Inhibition of P-gp and CYP3A4. 基于抑制 P-gp 和 CYP3A4 的改善多柔比星口服吸收的新型水飞蓟宾共轭壳聚糖聚合物胶束

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-17 DOI: 10.1021/acs.biomac.4c00628

Yuhan Yang, Yangyi Chen, Yue Wei, Wei Wu, Qing Wang, Tianyun Xue, Xiaoyan Zhang, Wei Chen, Wei Zhang

引用次数: 0

Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessment. 可再生光交联聚酯基生物材料：合成、表征和细胞相容性评估。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-17 DOI: 10.1021/acs.biomac.4c00599

Teresa Cernadas, João Pereira, Bruna L Melo, Duarte de Melo-Diogo, Ilídio J Correia, Patrícia Alves, Paula Ferreira

{"title":"Renewable Photo-Cross-Linkable Polyester-Based Biomaterials: Synthesis, Characterization, and Cytocompatibility Assessment.","authors":"Teresa Cernadas, João Pereira, Bruna L Melo, Duarte de Melo-Diogo, Ilídio J Correia, Patrícia Alves, Paula Ferreira","doi":"10.1021/acs.biomac.4c00599","DOIUrl":"10.1021/acs.biomac.4c00599","url":null,"abstract":"The present work consist of the synthesis of photo-cross-linkable materials, based on unsaturated polyesters (UPs), synthesized from biobased monomers from renewable sources such as itaconic acid and 1,4-butanediol. The UPs were characterized to assess the influence of polycondensation reaction temperature and cross-linking time on their final properties. For this purpose, different UV irradiation exposure periods were tested. Homogeneous, uniform, and transparent films were obtained after 1, 3, and 5 min of UV exposure. These cross-linked films were then characterized. All materials presented high gel content, which was dependent on the reaction's temperature. The thermal behaviors of the UPs were shown to be similar. In vitro hydrolytic degradation tests showed that the materials can undergo degradation in phosphate-buffered saline (PBS) at pH 7.4 and 37 °C, ensuring their biodegradability over time. Finally, to assess the applicability of the polyesters as biomaterials, their cytocompatibility was determined by using human dermal fibroblasts.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7134-7145"},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142453424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Process Control of Multistep Surface Functionalization on Hydroxyethyl Starch Nanocapsules Determines the Reproducibility of the Biological Efficacy. 羟乙基淀粉纳米胶囊表面多步官能化的过程控制决定生物药效的可重复性

IF 8.3 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-22 DOI: 10.1021/acs.biomac.4c00490

Marie-Luise Frey, Svenja Morsbach, Matthias Domogalla, Volker Mailänder, Kerstin Steinbrink, Katharina Landfester

{"title":"Process Control of Multistep Surface Functionalization on Hydroxyethyl Starch Nanocapsules Determines the Reproducibility of the Biological Efficacy.","authors":"Marie-Luise Frey, Svenja Morsbach, Matthias Domogalla, Volker Mailänder, Kerstin Steinbrink, Katharina Landfester","doi":"10.1021/acs.biomac.4c00490","DOIUrl":"10.1021/acs.biomac.4c00490","url":null,"abstract":"Nanocarrier synthesis is highly process-dependent, leading to potential batch-to-batch variability if it is not controlled at each step. This variability affects the reproducibility of subsequent biomodification, resulting in unpredictable biological effects, particularly for bioactive molecules such as interleukin-2 (IL-2). Inconsistent conjugation can lead to variable treatment outcomes and severe side effects. Therefore, precise control of each synthesis step is critical for ensuring a consistent quality and biological performance. Our study demonstrates that dividing nanocarrier synthesis into smaller, controlled steps improves reproducibility. Using this method, we achieved highly reproducible, concentration-dependent growth of CTLL-2 cells with hydroxyethyl starch (HES) nanocapsules functionalized with defined amounts of IL-2. We believe that such detailed, stepwise control in nanocarrier synthesis enhances batch consistency, improving the clinical applicability of the drug delivery systems.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7108-7122"},"PeriodicalIF":8.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Healable Hydrogels from Vegetable Oil: Preparation, Mechanism, and Applications. 植物油自愈合水凝胶：制备、机理和应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-22 DOI: 10.1021/acs.biomac.4c01009

Chandrapaul Mukherjee, Avik Ghosh, Tamilarasi M, Kartik Ravishankar, Abhijit K Das, Mariappan Selvaraj, Saikat Chaudhuri, Jit Sarkar

{"title":"Self-Healable Hydrogels from Vegetable Oil: Preparation, Mechanism, and Applications.","authors":"Chandrapaul Mukherjee, Avik Ghosh, Tamilarasi M, Kartik Ravishankar, Abhijit K Das, Mariappan Selvaraj, Saikat Chaudhuri, Jit Sarkar","doi":"10.1021/acs.biomac.4c01009","DOIUrl":"10.1021/acs.biomac.4c01009","url":null,"abstract":"Hydrogels are indispensable for a variety of applications. Conventional biomaterial-based hydrogels, typically made from proteins or polysaccharides, often suffer from high costs, poor mechanical properties, and limited chemical functionality for modification. In this work, we present a novel hydrogel developed from modified castor oil, which is a renewable and cost-effective resource. Castor oil-based oligomer (CG) was synthesized using glycidyl methacrylate and triethylamine via ring-opening polymerization. The oligomer formed a gel only with Cu2+ ions among the various systematically studied metal ions. Comprehensive density functional theory calculations, atoms in molecules analysis, and steady and dynamic shear rheology were conducted to investigate the metal-binding sites and metal-oligomer interactions as well as the self-healing and viscoelastic properties of the oil-based hydrogels. The hydrogel exhibited 94% self-healing efficiency and performed as a recyclable rhodamine B dye adsorbent (73-90%). This innovative approach offers a novel, cost-effective, and sustainable alternative to traditional hydrogels, paving the way for advanced applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7323-7333"},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142491097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scalable Production and Biophysical Characterization of High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin as Potential Red Blood Cell Substitutes. 作为潜在红细胞替代品的高分子量松弛和紧张四价态聚合人血红蛋白的规模化生产和生物物理特征。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-30 DOI: 10.1021/acs.biomac.4c01024

Mohd Asim Khan, Tanmay Salvi, Griffin J Beyer, Amna Abdalbaqi, Megan Allyn, Alejandro Bresolin, Andre F Palmer

{"title":"Scalable Production and Biophysical Characterization of High-Molecular-Weight Relaxed and Tense Quaternary State Polymerized Human Hemoglobin as Potential Red Blood Cell Substitutes.","authors":"Mohd Asim Khan, Tanmay Salvi, Griffin J Beyer, Amna Abdalbaqi, Megan Allyn, Alejandro Bresolin, Andre F Palmer","doi":"10.1021/acs.biomac.4c01024","DOIUrl":"10.1021/acs.biomac.4c01024","url":null,"abstract":"High-molecular-weight (HMW) (>500 kDa) glutaraldehyde-polymerized human hemoglobin (PolyhHb) is a promising hemoglobin-based oxygen carrier (HBOC) due to its decreased risk of vasoconstriction and oxidative tissue injury. Previously, HMW tense (T) quaternary state PolyhHb was synthesized at the pilot scale with tangential flow filtration (TFF) for the removal of low-molecular-weight species. However, T-state PolyhHb is limited to specific biomedical applications due to its low oxygen affinity, thus motivating the need to produce high oxygen affinity relaxed (R) quaternary state PolyhHb at the pilot scale. This study explored the pilot-scale synthesis and extensive biophysical characterization of both HMW T- and R-state PolyhHb. The resultant characterization demonstrated the successful synthesis of low and high oxygen affinity PolyhHb with increased molecular weight (∼1000-1500 kDa). Overall, T- and R-state PolyhHb provides a platform for manufacturing oxygen therapeutics with a diverse range of oxygen affinities and potential biomedical applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7334-7348"},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strong Hydrogen Bonds Sustain Even-Odd Effects in Poly(ester amide)s with Long Alkyl Chain Length in the Backbone. 强氢键可维持骨架烷基链长的聚酯酰胺的偶数效应

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 Epub Date: 2024-10-29 DOI: 10.1021/acs.biomac.4c01191

Leire Sangroniz, Jorge L Olmedo-Martínez, Wenxian Hu, Yoon-Jung Jang, Guoming Liu, Marc A Hillmyer, Alejandro J Müller

{"title":"Strong Hydrogen Bonds Sustain Even-Odd Effects in Poly(ester amide)s with Long Alkyl Chain Length in the Backbone.","authors":"Leire Sangroniz, Jorge L Olmedo-Martínez, Wenxian Hu, Yoon-Jung Jang, Guoming Liu, Marc A Hillmyer, Alejandro J Müller","doi":"10.1021/acs.biomac.4c01191","DOIUrl":"10.1021/acs.biomac.4c01191","url":null,"abstract":"The number of methylene groups between strongly interacting functional groups within polymer repeating units induces even-odd effects on thermal and mechanical properties. However, detailed studies correlating the even-odd effect with structural changes are still lacking. In this work, we establish correlations between the structure and thermal properties of poly(ester amide)s containing long alkyl chain lengths. The even-odd effect impacts the thermal properties, including the melting temperature and crystallinity degree. It influences the spherulitic morphology of poly(ester amide)s, controlling the appearance of banding. We demonstrate that even-odd effects in poly(ester amides)s persist even with 27 CH2 groups within the repeating unit, an effect due to strong hydrogen bonds caused by the amide groups. Our X-ray studies reveal that the even-odd effect originates from changes in the crystalline structure of the materials. This work helps elucidate the role of strong intermolecular interactions (i.e., hydrogen bonding) on the even-odd effect in long-chain poly(ester amides).","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7500-7510"},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142542856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure. 具有可调结构的两性碳硅烷-膦树枝状化合物的自适应合成、超分子行为和生物特性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-11-11 DOI: 10.1021/acs.biomac.4c01092

Antonín Edr, Dominika Wrobel, Alena Krupková, Lucie Červenková Št Astná, Evgeny Apartsin, Michaela Hympánová, Jan Marek, Jan Malý, Marek Malý, Tomáš Strašák

{"title":"Adaptive Synthesis, Supramolecular Behavior, and Biological Properties of Amphiphilic Carbosilane-Phosphonium Dendrons with Tunable Structure.","authors":"Antonín Edr, Dominika Wrobel, Alena Krupková, Lucie Červenková Št Astná, Evgeny Apartsin, Michaela Hympánová, Jan Marek, Jan Malý, Marek Malý, Tomáš Strašák","doi":"10.1021/acs.biomac.4c01092","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01092","url":null,"abstract":"Here, we present a modular synthesis as well as physicochemical and biological evaluation of a new series of amphiphilic dendrons carrying triphenylphosphonium groups at their periphery. Within the series, the size and mutual balance of lipophilic and hydrophilic domains are systematically varied, changing the dendron shape from cylindrical to conical. In physiological solution, the dendrons exhibit very low critical micelle concentrations (2.6-4.9 μM) and form stable and uniform micelles 6-12 nm in diameter, depending on dendron shape; the results correlate well with molecular dynamics simulations. The compounds show relatively high cytotoxicity (IC50 1.2-21.0 μM) associated with micelle formation and inversely related to the size of assembled particles. Depending on their shape, the dendrons show promising results in terms of dendriplex formation and antibacterial activity. In addition to simple amphiphilic dendrons, a fluorescently labeled analogue was also prepared and utilized as an additive visualizing the dendron's cellular uptake.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0