Biomacromolecules最新文献_第4页

Thermal Unlocking of Cellulose Mercerization: High-Temperature Low-Concentration Phase Transition and the Twist−Stabilize−Lock Mechanism 纤维素丝光的热解锁：高温低浓度相变和扭转-稳定-锁机制

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-24 DOI: 10.1021/acs.biomac.6c01044

Masaumi Miyabayashi, Paavo Penttilä, Yoshiki Horikawa

{"title":"Thermal Unlocking of Cellulose Mercerization: High-Temperature Low-Concentration Phase Transition and the Twist−Stabilize−Lock Mechanism","authors":"Masaumi Miyabayashi, Paavo Penttilä, Yoshiki Horikawa","doi":"10.1021/acs.biomac.6c01044","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01044","url":null,"abstract":"Solid-state polymorphic transition from cellulose I to II (mercerization) generally requires high alkali concentrations (>12−15 wt %) to overcome hydrogen-bonding networks and topological barriers. In this study, we elucidated the phase behavior of cellulose in a high-temperature, low-concentration regime using in situ Fourier-transform infrared spectroscopy in D2O and non-negative matrix factorization (NMF). Phase mapping demonstrated that the alkali threshold for mercerization decreased to approximately 5 wt % above 60 °C. NMF analysis established kinetic markers that distinguished alkali-induced structural evolution from overlapping spectral responses. The results suggest that elevated temperature promotes transient local loosening of cohesive contacts, accompanied by reorganization of structured water and increased conformational freedom. Spectroscopic tracking of backbone geometry revealed a Twist−Stabilize−Lock mechanism initiated by reduction of the glycosidic bond angle. This thermally assisted unlocking process facilitates alkali-assisted structural rearrangement under dilute conditions, extending mercerization into a low-alkali regime distinct from dissolution−regeneration pathways. These findings provide a mechanistic basis for reducing alkali consumption and designing thermally assisted cellulose processing and surface-modification strategies.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6568–6579"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passively Targeted Polymeric Nanocarrier Delivering STAT1 siRNA to the Liver Ameliorates Steatohepatitis and Fibrosis in the Thioacetamide Mouse Model 被动靶向聚合纳米载体向肝脏递送STAT1 siRNA可改善硫乙酰胺小鼠模型中的脂肪性肝炎和纤维化

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-29 DOI: 10.1021/acs.biomac.6c00375

Klea Mehmetaj, Antea Jorgo, WanLing Foo, Zoltán Cseresnyés, Julian Plitzko, Tanveer Ahmed Shaik, Quratul Ain, Anuradha Ramoji, Sophie Huschke, Ling Xiong, Alexander Zipprich, Jürgen Popp, Marc Thilo Figge, Volker Deckert, Stephanie Schubert, Nikolaus Gassler, Felix H. Schacher, Michael Bauer, Adrian T. Press

{"title":"Passively Targeted Polymeric Nanocarrier Delivering STAT1 siRNA to the Liver Ameliorates Steatohepatitis and Fibrosis in the Thioacetamide Mouse Model","authors":"Klea Mehmetaj, Antea Jorgo, WanLing Foo, Zoltán Cseresnyés, Julian Plitzko, Tanveer Ahmed Shaik, Quratul Ain, Anuradha Ramoji, Sophie Huschke, Ling Xiong, Alexander Zipprich, Jürgen Popp, Marc Thilo Figge, Volker Deckert, Stephanie Schubert, Nikolaus Gassler, Felix H. Schacher, Michael Bauer, Adrian T. Press","doi":"10.1021/acs.biomac.6c00375","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c00375","url":null,"abstract":"Liver fibrosis is a major complication of chronic liver injury, driven in part by Signal Transducer and Activator of Transcription 1 (Stat1). This study evaluated passively liver-targeted polymeric nanocarriers delivering Stat1 siRNA (siSTAT1) to treat steatohepatitis and fibrosis in a thioacetamide (TAA) mouse model. Two polyplex nanocarriers with different core−corona ratios, EN15 and EN76, were tested in TAA-treated mice and activated human and murine hepatocytes. In vitro, both formulations enabled efficient cellular uptake and Stat1 silencing, reducing TAA-induced lipid accumulation. Through an In vivo approach, mice received TAA for 16 weeks followed by four weeks of siSTAT1 treatment. Both formulations reduced collagen deposition, hepatic inflammation, and fibrosis scores. Notably, EN76, which preferentially targets non-parenchymal cells, showed superior antifibrotic efficacy compared with EN15. These findings highlight Stat1 as a key driver of steatohepatitis and fibrosis and support passive siRNA delivery, particularly via EN76, as a promising therapeutic strategy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6351–6367"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149174050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Confinement-Activated Fluorescence Enhancement of Dyes via Polymer-Mediated Interfacial Regulation in Cellulose Nanocrystal Films 纤维素纳米晶膜中聚合物介导的界面调控对染料的监禁激活荧光增强

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-22 DOI: 10.1021/acs.biomac.6c01265

Decai Xiong, Peijun Zhang, Hongchen He, Yao Lu, Yixiao Dong, Jiaolong Liu, Deting Xu, Yanyang Qin, Junkai Ren, Bing Wei, Dan Qu

{"title":"Confinement-Activated Fluorescence Enhancement of Dyes via Polymer-Mediated Interfacial Regulation in Cellulose Nanocrystal Films","authors":"Decai Xiong, Peijun Zhang, Hongchen He, Yao Lu, Yixiao Dong, Jiaolong Liu, Deting Xu, Yanyang Qin, Junkai Ren, Bing Wei, Dan Qu","doi":"10.1021/acs.biomac.6c01265","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01265","url":null,"abstract":"Controlling dye emission under confinement remains challenging because of aggregation-caused quenching. Here, we report a confinement-activated mechanism for polymer-mediated regulation of interfacial and dye emission in cellulose nanocrystal (CNC)-based systems. PEG induces negligible photophysical changes in suspension but dramatically enhances fluorescence in films, increasing the quantum yield of rhodamine 6G (Rh6G) from 0.03% to 57.42% with a prolonged fluorescence lifetime. Spectroscopic and molecular dynamics analyses show that PEG regulates dye−dye and CNC-dye organization through steric and interfacial effects. Solvent-mediated interactions largely screen these perturbations in suspension, whereas solvent removal enables cooperative regulation by the rigid CNC framework and flexible PEG chains, redistributing local dimer geometries and excitonic coupling. The fluorescence enhancement extends to multiple cationic dyes but depends strongly on the molecular structure. These findings establish a molecular framework linking polymer-mediated interfacial regulation, confinement, and dye structure, providing a strategy for tuning the emission in polysaccharide-based materials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6654–6666"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aromatic Dipeptide−Polymer-Derived Carboxylated Nanospheres for Hg2+ Binding 芳香族二肽-聚合物衍生羧化纳米微球用于Hg2+结合

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-18 DOI: 10.1021/acs.biomac.6c00458

Anil K. Yadav, Partha P. Deka, Nandita Madhavan

{"title":"Aromatic Dipeptide−Polymer-Derived Carboxylated Nanospheres for Hg2+ Binding","authors":"Anil K. Yadav, Partha P. Deka, Nandita Madhavan","doi":"10.1021/acs.biomac.6c00458","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c00458","url":null,"abstract":"Functionalized peptide−polymer conjugates have been used for applications such as drug delivery, catalysis, metal-ion binding, and gas separation due to their low toxicity. Reported herein is an acyclic aromatic dipeptide−polynorbornene conjugate decorated with carboxylate groups for cation binding. The peptide−polymer conjugate is prepared using an aromatic dipeptide scaffold functionalized with norbornene that readily self-assembles to form spherical aggregates. The self-assembly is covalently captured using ring-opening metathesis polymerization in the presence of a crosslinker to give robust nanospheres. Hydrolysis of the peptide C-terminus affords the carboxylated spheres with excellent thermal stability. These nanospheres can selectively remove 27.94 mg g−1 of Hg(II) ions, which translates to an 86.5% removal efficiency. The nanospheres being insoluble can be readily isolated, regenerated, and reused for mercury removal without compromising the removal efficiency. Owing to their stability, selectivity, and reusability, the carboxylated spheres offer exciting prospects for environmental remediation applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6384–6392"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arabinoxylan Hydrogels as a Novel Encapsulation System with Triggered Release by Gut Bacterial Enzymes 阿拉伯木聚糖水凝胶作为肠道细菌酶触发释放的新型包封体系

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-11 DOI: 10.1021/acs.biomac.6c00285

Carl Rämgård, Lauren S. McKee, Francisco Vilaplana

{"title":"Arabinoxylan Hydrogels as a Novel Encapsulation System with Triggered Release by Gut Bacterial Enzymes","authors":"Carl Rämgård, Lauren S. McKee, Francisco Vilaplana","doi":"10.1021/acs.biomac.6c00285","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c00285","url":null,"abstract":"Arabinoxylans are ubiquitous plant biopolymers present in large amounts in cereal bran, a major underutilized side stream of the agrifood industry. Their unique structural properties make them promising matrices for the design of hydrogels for nutritional and pharmacological applications. We report the controlled production of laccase-crosslinked arabinoxylan hydrogels derived from wheat (WAX) and rye (RAX) bran with tuned porous properties via the modulation of freeze-drying temperature, with implications for biostimulatory encapsulation and release. Freezing in liquid nitrogen generated smaller pore sizes in both systems, while RAX hydrogels consistently displayed higher porosity and elastic moduli than WAX hydrogels, reflecting differences in chemical cross-linking density, solid content, and physical network organization. Rheological analyses revealed a correlation between solid content and porosity with enhanced elastic properties, highlighting the poroelastic contributions to hydrogel mechanics. The hydrogels exhibited varying encapsulation and retention ability of the target biomolecules (glucose, tryptophan, and green fluorescent protein), reflecting differences in molecular size and chemistry. Retention of small molecules was dictated primarily by matrix affinity, whereas larger proteins were retained predominantly based on pore size and porosity. Enzymatic degradation by a gut bacteria β-xylanase-triggered cargo release, demonstrating the potential of arabinoxylan hydrogels, as targeted gastrointestinal delivery platforms.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6328–6338"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Sterilization Techniques on the Physicochemical and Biological Properties, and 3D Printability of Thermoresponsive Hydrogels 灭菌技术对热敏水凝胶的物理化学和生物特性以及3D打印能力的影响

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-25 DOI: 10.1021/acs.biomac.6c01032

Saba Nemati Mahand, Saumya Palliyawaththage, J. Maurice Pütz, Parsa Amin, Ekaterina Takmakova, Robert Luxenhofer

{"title":"Impact of Sterilization Techniques on the Physicochemical and Biological Properties, and 3D Printability of Thermoresponsive Hydrogels","authors":"Saba Nemati Mahand, Saumya Palliyawaththage, J. Maurice Pütz, Parsa Amin, Ekaterina Takmakova, Robert Luxenhofer","doi":"10.1021/acs.biomac.6c01032","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01032","url":null,"abstract":"Three-dimensional bioprinting offers transformative potential for functional disease modeling and tissue engineering. These applications demand effective biomaterial sterilization to ensure reproducibility and clinical translation. This study evaluated pharmacopeia-standard disinfection and sterilization methods, including autoclaving, dry heat treatment (aerobic and anaerobic), ethanol washing (70%), UV irradiation, and filtration on three thermoresponsive hydrogels. The investigated hydrogels consist of Pluronic F127 (poloxamer 407) or two poly(2-oxazolines)/poly(2-oxazine) based block copolymers, namely poly(2-methyl-2-oxazoline)-b-poly(2-n-propyl-2-oxazine) (pMeOx-b-pnPrOzi), or poly(2-methyl-2-oxazoline)-b-poly(2-phenyl-2-oxazine)-b-poly(2-methyl-2-oxazoline) (pMeOx-b-pPheOzi-b-pMeOx). Results showed that ethanol washing and UV irradiation sterilized inefficiently, while dry heat treatment caused partial thermal degradation (all polymers), compromised 3D-printability, and increased cytotoxicity (Pluronic F127), likely due to the formation of oxidative degradation products. Filtration effectively sterilized both pMeOx-based block copolymers, while Pluronic F127 required a combined approach of autoclaving and triple filtration to achieve complete sterility. Overall, filtration and autoclaving emerged as the most suitable sterilization method, balancing chemical stability, mechanical integrity, printability, and cytocompatibility.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6527–6542"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supramolecular Hemoglobin−PEG Polymerization Equilibria as the Structural Basis for Providing Size-Controlled Polymer Particles 超分子血红蛋白-聚乙二醇聚合平衡作为提供尺寸控制聚合物颗粒的结构基础

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-30 DOI: 10.1021/acs.biomac.6c01459

Takashi Matsuhira, Masahiro Nagao, Yuki Nakano, Hiromi Sakai

{"title":"Supramolecular Hemoglobin−PEG Polymerization Equilibria as the Structural Basis for Providing Size-Controlled Polymer Particles","authors":"Takashi Matsuhira, Masahiro Nagao, Yuki Nakano, Hiromi Sakai","doi":"10.1021/acs.biomac.6c01459","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01459","url":null,"abstract":"Hemoglobin (Hb) can act as a dynamic supramolecular building block through the reversible dissociation of the α2β2 tetramer into αβ dimers. For this study, we designed structurally defined bicyclic monomers in which the β subunits in two Hb molecules are bridged through four-armed PEG of different molecular weights (10 and 40 kDa). These bicyclic monomers undergo concentration-dependent supramolecular ring-opening polymerization, enabling predictable control of polymer structure from discrete monomers to polymer particles and finally to a percolated polymer gel network. Extensive physicochemical analyses revealed quantitative shifts in polymerization equilibria that govern these supramolecular assemblies. Furthermore, intramolecular ββ-cross-linking of Hb moiety with bis-(3,5-dibromosalicyl) fumarate (DBBF) allowed selective covalent fixation of each supramolecular polymer species, affording fixed bicyclic monomers, fixed polymer particles, and fixed polymer gels with controlled sizes. These fixed Hb−PEG architectures retained characteristic O2-binding properties. Overall, this work establishes a supramolecular-to-covalent polymer conversion platform that enables precise structural control in Hb-based polymer architectures, thereby expanding the design space for protein−polymer biomaterials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6840–6852"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A FRET-Based Fluorometric Assay for Tracking the Enzymatic Degradation of Poly-l-Lactic Acid 基于fret的荧光法测定聚乳酸的酶降解

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-27 DOI: 10.1021/acs.biomac.6c01709

Mahbub Ullah, Jordan A. Cannon, Todd B. Reynolds, Michael D. Best

{"title":"A FRET-Based Fluorometric Assay for Tracking the Enzymatic Degradation of Poly-l-Lactic Acid","authors":"Mahbub Ullah, Jordan A. Cannon, Todd B. Reynolds, Michael D. Best","doi":"10.1021/acs.biomac.6c01709","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01709","url":null,"abstract":"Protein engineering has recently emerged as a promising strategy for enhancing the enzymatic recycling of bio-based polymers with the aim of replacing non-degradable petroleum-based plastics with biodegradable ones like poly-l-lactic acid (PLLA). However, a significant challenge exists in the evaluation of the biodegradation efficiency of newly developed enzymes. The precise tracking and continuous rate monitoring of the enzyme-catalyzed hydrolysis remain difficult to achieve with a conventional l-lactate assay kit, which provides only endpoint measurements and is therefore decoupled from the real-time degradation process. To address this issue, we introduce a novel Förster Resonance Energy Transfer (FRET)-based PLLA substrate capable of monitoring real-time PLLA degradation. This was achieved by connecting a highly fluorescent amino carbamoyl coumarin (ACC) dye with a quencher (2,4-dinitrophenyl-l-lysine) via a tetrameric oligo-l-lactate chain. Several fluorescence studies demonstrate that this substrate can effectively detect PLLA-degrading enzyme activity by monitoring increased fluorescence due to enzyme-catalyzed hydrolysis of the oligolactate chain and disruption of the intramolecular FRET system. This substrate can be a potent replacement for the conventional l-lactate assay kit as it allows fast and accurate tracking of the enzyme activity toward PLLA.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6998–7006"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Aldehyde-Functionalized Polysaccharide Biosponge for Rapid Absorbable Hemostasis and Skin Tissue Regeneration 用于快速可吸收止血和皮肤组织再生的醛功能化多糖生物海绵

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-26 DOI: 10.1021/acs.biomac.6c01504

Thiyaneshwar Ramamoorthy, Anisha Kabir, Banamali Sahu, Vimalraj Selvaraj, Arockiarajan Arunachalakasi, Swathi Sudhakar

{"title":"An Aldehyde-Functionalized Polysaccharide Biosponge for Rapid Absorbable Hemostasis and Skin Tissue Regeneration","authors":"Thiyaneshwar Ramamoorthy, Anisha Kabir, Banamali Sahu, Vimalraj Selvaraj, Arockiarajan Arunachalakasi, Swathi Sudhakar","doi":"10.1021/acs.biomac.6c01504","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01504","url":null,"abstract":"Massive hemorrhage and impaired wound healing continue to pose critical clinical challenges, particularly due to the limitations of currently available commercial hemostatic dressings, which often exhibit delayed clot formation, poor regenerative potential, and incomplete biodegradation, leading to secondary inflammation. Here, we developed a hemostatic biosponge from aldehyde-functionalized Colocasia esculenta mucilage (OCO) to address these limitations. The introduction of reactive aldehyde groups forms Schiff's base interactions with amine groups present in blood components, facilitating efficient red blood cell entrapment and accelerated coagulation. In vitro studies demonstrated that the sponge effectively absorbs blood, exhibits blood-clotting ability, and is biocompatible. In vivo studies using a rat liver laceration model showed that the OCO sponge achieved hemostasis within 30 ± 2.4 s, significantly faster than the 102 ± 1.3 s required by a commercial gelatin sponge, highlighting its superior hemostatic performance. Furthermore, in vivo full-thickness skin wound studies confirmed enhanced wound healing, with the OCO-treated group exhibiting 1.10-fold greater wound closure by day 18 compared to the gelatin sponge group and showing gradual resorption without adverse tissue reaction, thereby minimizing the risk of chronic inflammation. Therefore, this engineered OCO biosponge represents a promising biomaterial for bleeding control and skin tissue repair in traumatic conditions.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6865–6878"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lignin-Enabled Cell Wall Engineering of Wood for Integrated Photothermal Conversion and Phase Change Energy Storage 用于光热转换和相变储能的木质素激活木材细胞壁工程

IF 5.9 2区化学

Biomacromolecules Pub Date : 2026-10-12 Epub Date: 2026-09-07 DOI: 10.1021/acs.biomac.6c01239

Xuetong Shi, Yi Lu, Yi Hu, Ran Bi, Peipei Wang, Orlando J. Rojas

{"title":"Lignin-Enabled Cell Wall Engineering of Wood for Integrated Photothermal Conversion and Phase Change Energy Storage","authors":"Xuetong Shi, Yi Lu, Yi Hu, Ran Bi, Peipei Wang, Orlando J. Rojas","doi":"10.1021/acs.biomac.6c01239","DOIUrl":"https://doi.org/10.1021/acs.biomac.6c01239","url":null,"abstract":"Wood-based phase-change composites are promising for solar-thermal energy storage and thermal regulation. However, native wood limits phase-change material (PCM) uptake, whereas extensive delignification removes lignin’s intrinsic light-harvesting capacity. We developed a cell−wall nano-engineering approach using aqueous p-toluenesulfonic acid to partially remove hemicellulose and redistribute retained lignin. This treatment increased cell-wall accessibility while preserving the wood's photothermal function. After impregnation with poly(ethylene glycol) impregnation, the resulting composite achieved a melting enthalpy of 154.9 J g−1 and an encapsulation efficiency of 78.5%. It showed no visible leakage at 80 °C and maintained stable thermal-storage performance over 100 heating−cooling cycles (differential scanning calorimetry). Lignin redistribution and reassembly within the cell wall also improved water repellency and moisture resistance. Compared with native- and delignified-wood controls, the composite showed stronger broadband absorption and an apparent photothermal conversion efficiency of 83.2% under two-sun irradiation. This lignin-retaining strategy integrates physical PCM confinement, thermal storage, and intrinsic photothermal conversion without requiring additional light absorbers.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"27 10","pages":"6636–6645"},"PeriodicalIF":5.9,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149173648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0