Biomacromolecules最新文献_第5页

Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation. 由甲基丙烯酰明胶、羧甲基葡聚糖和透明质酸组成的博舒替尼负载纳米凝胶在结直肠癌控制给药中的 pH 反应性和聚合稳定性比较研究：广泛的体外研究

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-06 DOI: 10.1021/acs.biomac.4c01209

Sankha Bhattacharya, Shashikant Bagade, Preeti Chidambar Sangave, Devendra Kumar, Imran Shaik, Dhrubojyoti Mukherjee

{"title":"Comparative Study of pH-Responsive and Aggregation Stability of Bosutinib-Loaded Nanogels Comprising Gelatin Methacryloyl, Carboxymethyl Dextran, and Hyaluronic Acid for Controlled Drug Delivery in Colorectal Cancer: An Extensive In Vitro Investigation.","authors":"Sankha Bhattacharya, Shashikant Bagade, Preeti Chidambar Sangave, Devendra Kumar, Imran Shaik, Dhrubojyoti Mukherjee","doi":"10.1021/acs.biomac.4c01209","DOIUrl":"10.1021/acs.biomac.4c01209","url":null,"abstract":"This study investigates the use of pH-responsive nanogels for delivering Bosutinib (BOSU) in colon cancer treatment. Nanogels were formulated using three polymers: hyaluronic acid (HA), carboxymethyl dextran (CMD), and gelatin methacryloyl (GelMA). These nanogels achieved high drug entrapment efficiencies (80-90%) through polymer mixing with BOSU, followed by EDC/NHS cross-linking and sonication. The nanogels were stable, with negative zeta potentials (-20 to -30 mV) and particle sizes between 100 and 200 nm. Fourier-transform infrared analysis confirmed successful methacrylation in GelMA nanogels. Sustained BOSU release at pH 5.0 was observed, resembling tumor environments, compared to slower release at normal pH (7.4). Cytotoxicity tests showed 70-80% cell survival reduction in HCT116 colon cancer cells at higher doses, and GelMA-BOSU nanogels notably reduced cell migration. Antiangiogenic effects were confirmed in a chick chorioallantoic membrane model, highlighting the potential of these nanogels for targeted BOSU delivery in colon cancer therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7926-7950"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkylated RALA-Derived Peptides for Efficient Gene Delivery. 用于高效基因传递的烷基化 RALA 衍生肽。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-13 DOI: 10.1021/acs.biomac.4c01355

Xuelin Zhang, Yexi Zhang, Xi Rong, Chuanmei Tang, Huiye Liu, Lei Yue, Rongxin Su, Yuefei Wang, Wei Qi

引用次数: 0

Chitosan-Promoted TiO₂-Loaded Double-Network Hydrogels for Dye Removal and Wearable Sensors. 壳聚糖促进的 TiO2 负载双网水凝胶用于染料去除和可穿戴传感器。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-14 DOI: 10.1021/acs.biomac.4c01286

Wei Gao, Huichun Kang, Ming Zhong, Lijuan Han, Xue Guo, Bitao Su, Ziqiang Lei

{"title":"Chitosan-Promoted TiO2-Loaded Double-Network Hydrogels for Dye Removal and Wearable Sensors.","authors":"Wei Gao, Huichun Kang, Ming Zhong, Lijuan Han, Xue Guo, Bitao Su, Ziqiang Lei","doi":"10.1021/acs.biomac.4c01286","DOIUrl":"10.1021/acs.biomac.4c01286","url":null,"abstract":"The loading of photocatalysts on hydrogels can significantly reduce the loss of catalysts and effectively prevent secondary contamination, thus demonstrating great application potential and advantages in the field of wastewater treatment, especially in the removal of dyes. Herein, the semiconductor TiO2 was successfully loaded into a polyacrylic acid/chitosan (PAA/CS) double-network (DN) hydrogel, which exhibited superior removal of dyes in wastewater such as MG, MB, MV, and RhB. The dye degradation process followed first-order kinetics, and the first-order rate constants for dye degradation were further calculated under UV light irradiation. Furthermore, the photocatalytic mechanism of the hydrogel was explored and analyzed. More interestingly, the PAA/CS-TiO2 DN hydrogel has excellent tensile properties and superior electrical conductivity, which can be assembled into flexible sensors for real-time monitoring of mechanical deformations and human joint motions. It is envisioned that these excellent properties make hydrogel photocatalysts promising for a wide range of applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"8016-8025"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Improved Redispersibility of Cellulose Nanocrystals Using Hydroxypropyl Cellulose and Structure Color from Redispersed Cellulose Nanocrystals. 利用羟丙基纤维素改善纤维素纳米晶体的再分散性以及再分散纤维素纳米晶体的结构色。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-15 DOI: 10.1021/acs.biomac.4c01277

Huan Wang, Lukuan Guo, Mingfeng Wu, Guang Chu, Wenyuan Zhu, Junlong Song, Jiaqi Guo

{"title":"The Improved Redispersibility of Cellulose Nanocrystals Using Hydroxypropyl Cellulose and Structure Color from Redispersed Cellulose Nanocrystals.","authors":"Huan Wang, Lukuan Guo, Mingfeng Wu, Guang Chu, Wenyuan Zhu, Junlong Song, Jiaqi Guo","doi":"10.1021/acs.biomac.4c01277","DOIUrl":"10.1021/acs.biomac.4c01277","url":null,"abstract":"Cellulose nanocrystals (CNC) have been significantly developed as a building block material for the design of novel functional materials in many fields such as biomedicine, nanotechnology, and materials science due to their excellent optical properties, biocompatibility, and sustainability. Improving the redispersibility of CNC in the sustainable processing of nanocellulose has been a challenge because intense hydrogen bond interaction leads to irreversible aggregation, making CNC difficult to redisperse and increasing the cost of storage and transportation of CNC. Hydroxypropyl cellulose (HPC) is an important hydroxy propylated cellulose ether. As a water-soluble cellulose derivative, HPC has a polyhydroxy structure similar to that of CNC, which leads to good compatibility and high affinity between HPC and CNC. In this work, HPC of different molecular weights was comixed with CNC of different contents, which was then dried using different methods, and the dried samples were redispersed in water. The addition of HPC improved the redispersibility of the CNC. Finally, the redispersed suspension was also redried to form a film, which was found to retain its structure color. These results provide an important avenue for the redispersion of dried CNC and for the development of functional materials from redispersed CNC.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"8006-8015"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-Step Synthesis of Highly Sensitive ¹⁹F MRI Tracers by Gradient Copolymerization-Induced Self-Assembly. 通过梯度共聚诱导自组装一步合成高灵敏度 19F MRI 示踪剂。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-18 DOI: 10.1021/acs.biomac.4c00915

Vyshakh M Panakkal, Dominik Havlicek, Ewa Pavlova, Klara Jirakova, Daniel Jirak, Ondrej Sedlacek

{"title":"Single-Step Synthesis of Highly Sensitive 19F MRI Tracers by Gradient Copolymerization-Induced Self-Assembly.","authors":"Vyshakh M Panakkal, Dominik Havlicek, Ewa Pavlova, Klara Jirakova, Daniel Jirak, Ondrej Sedlacek","doi":"10.1021/acs.biomac.4c00915","DOIUrl":"10.1021/acs.biomac.4c00915","url":null,"abstract":"Amphiphilic gradient copolymers are promising alternatives to block copolymers for self-assembled nanomaterials due to their straightforward synthesis via statistical copolymerization of monomers with different reactivities and hydrophilicity. By carefully selecting monomers, nanoparticles can be synthesized in a single step through gradient copolymerization-induced self-assembly (gPISA). We synthesized highly sensitive 19F MRI nanotracers via aqueous dispersion gPISA of hydrophilic poly(ethylene glycol) methyl ether methacrylate (PEGMA) with core-forming N,N-(2,2,2-trifluoroethyl)acrylamide (TFEAM). The PPEGMA-grad-PTFEAM nanoparticles were optimized to achieve spherical morphology and exceptional 19F MRI performance. Noncytotoxicity was confirmed in Panc-1 cells. In vitro 19F MR relaxometry and imaging demonstrated their diagnostic imaging potential. Notably, these gradient copolymer nanotracers outperformed block copolymer analogs in 19F MRI performance due to their gradient architecture, enhancing 19F relaxivity. The synthetic versatility and superior 19F MRI performance of gradient copolymers highlight their potential in advanced diagnostic imaging applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7685-7694"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic Evaluation of Macromolecular Carbohydrate-Lectin Recognition Using Precision Glycopolymers. 利用精密聚糖对大分子碳水化合物-肌球蛋白识别进行系统评估。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-06 DOI: 10.1021/acs.biomac.4c01245

Cole A Williams, Daniel J Stone, Soumil Y Joshi, Gokhan Yilmaz, Parisa Farzeen, Sungjin Jeon, Zamira Harris-Ryden, C Remzi Becer, Sanket A Deshmukh, Cassandra E Callmann

{"title":"Systematic Evaluation of Macromolecular Carbohydrate-Lectin Recognition Using Precision Glycopolymers.","authors":"Cole A Williams, Daniel J Stone, Soumil Y Joshi, Gokhan Yilmaz, Parisa Farzeen, Sungjin Jeon, Zamira Harris-Ryden, C Remzi Becer, Sanket A Deshmukh, Cassandra E Callmann","doi":"10.1021/acs.biomac.4c01245","DOIUrl":"10.1021/acs.biomac.4c01245","url":null,"abstract":"The precise modulation of protein-carbohydrate interactions is critical in glycobiology, where multivalent binding governs key cellular processes. As such, synthetic glycopolymers are useful for probing these interactions. Herein, we developed precision glycopolymers (PGPs) with unambiguous local chemical composition and well-defined global structure and systematically evaluated the effect of polymer length, hydrophobicity, and backbone hybridization as well as glycan density and identity on the binding to both mammalian and plant lectins. Our studies identified glycan density as a critical factor, with PGPs below 50% grafting density showing significantly weaker lectin interactions. Coarse-grained molecular dynamics simulations suggest that the observed phenomena may be due to a decrease in carbohydrate-carbohydrate interactions in fully grafted PGPs, leading to improved solvent accessibility. In functional assays, these PGPs reduced the cell viability and migration in 4T1 breast cancer cells. Our findings establish a structure-activity relationship in glycopolymers, providing new strategies for designing synthetic glycomacromolecules for a myriad of applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7985-7994"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineering Thermoresponsive Enzyme-Polymer Conjugates via Glycan-Selective In Situ Polymerization for Recyclable Homogeneous Biocatalysis. 通过聚糖选择性原位聚合作用设计热致伸缩性酶-聚合物共轭物，用于可回收的均相生物催化。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-22 DOI: 10.1021/acs.biomac.4c01220

Huiru Wang, Shanyun Ma, Muyan Diao, Li Wenhui, Min Huan, Xiaofang Sun, Yuanzi Wu

引用次数: 0

Fungal Chitin Nanofibrils Improve Mechanical Performance and UV-Light Resistance in Carboxymethylcellulose and Polyvinylpyrrolidone Films. 真菌甲壳素纳米纤维改善了羧甲基纤维素和聚乙烯吡咯烷酮薄膜的机械性能和抗紫外线性能。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-11 DOI: 10.1021/acs.biomac.4c00846

Madalen Azpitarte Aretxabaleta, Gotzone Barandika, Rikardo Minguez, Erlantz Lizundia

{"title":"Fungal Chitin Nanofibrils Improve Mechanical Performance and UV-Light Resistance in Carboxymethylcellulose and Polyvinylpyrrolidone Films.","authors":"Madalen Azpitarte Aretxabaleta, Gotzone Barandika, Rikardo Minguez, Erlantz Lizundia","doi":"10.1021/acs.biomac.4c00846","DOIUrl":"10.1021/acs.biomac.4c00846","url":null,"abstract":"Materials from renewable carbon feedstock can limit our dependence on fossil carbon and facilitate the transition from linear carbon-intensive economies to sustainable, circular economies. Chitin nanofibrils (ChNFs) isolated from white mushrooms offer remarkable environmental benefits over conventional crustacean-derived nanochitin. Herein, ChNFs are utilized to reinforce polymers of natural and fossil origin, carboxymethyl cellulose (CMC) and polyvinylpyrrolidone (PVP), respectively. Incorporation of 5 wt % ChNFs increases the Young's modulus from 1217 ± 11 to 1509 ± 22 MPa for PVP and from 1979 ± 48 to 2216 ± 102 MPa for CMC. ChNFs increase surface hydrophobicity and retard the scission of the C-H bond as a result of UV-light irradiation in both polymers under investigation. The yellowing from chain scission is reduced, while long-lasting retention of ductility is ensured. Given these results, we propose the utilization of ChNFs in sustainable polymeric materials from renewable carbon with competitive performance against fossil-based benchmark plastics.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7630-7641"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Healing, Electrically Conductive, Antibacterial, and Adhesive Eutectogel Containing Polymerizable Deep Eutectic Solvent for Human Motion Sensing and Wound Healing. 自愈性、导电性、抗菌性和粘性共晶凝胶，含有可聚合的深共晶溶剂，用于人体运动传感和伤口愈合。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-14 DOI: 10.1021/acs.biomac.4c00960

Shaghayegh Vakili, Zahra Mohamadnia, Ebrahim Ahmadi

{"title":"Self-Healing, Electrically Conductive, Antibacterial, and Adhesive Eutectogel Containing Polymerizable Deep Eutectic Solvent for Human Motion Sensing and Wound Healing.","authors":"Shaghayegh Vakili, Zahra Mohamadnia, Ebrahim Ahmadi","doi":"10.1021/acs.biomac.4c00960","DOIUrl":"10.1021/acs.biomac.4c00960","url":null,"abstract":"Flexible electronic devices such as wearable sensors are essential to advance human-machine interactions. Conductive eutectogels are promising for wearable sensors, despite their challenges in self-healing and adhesion properties. This study introduces a multifunctional eutectogel based on a novel polymerizable deep eutectic solvent (PDES) prepared by the incorporation of diallyldimethylammonium chloride (DADMAC) and glycerol in the presence of polycyclodextrin (PCD)/dopamine-grafted gelatin (Gel-DOP)/oxidized sodium alginate (OSA). The synthesized eutectogel has reversible Schiff-base bonds, hydrogen bonds, and host-guest interactions, which enable rapid self-healing upon network disruption. GPDO-15 eutectogel has significant tissue adhesion, high stretchability (419%), good ionic conductivity (0.79 mS·cm-1), and favorable antibacterial and self-healing properties. These eutectogels achieve 90% antibacterial effect, show excellent biocompatibility, and can be used as sensors to monitor human activities with strong stability and durability. The in vivo studies indicate that the eutectogels can improve the wound healing process which makes them an effective option for biological dressings.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7704-7722"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-Responsive Nanoparticles for Smart Drug Delivery: A NIR Light-Sensitive and Redox-Reactive PEG-PCL-Based System. 用于智能给药的双响应纳米颗粒：基于近红外光敏和氧化还原反应的 PEG-PCL 系统。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2024-12-09 Epub Date: 2024-11-11 DOI: 10.1021/acs.biomac.4c00889

Nancy Ferrentino, Taha Behroozi Kohlan, Shokoufeh Mehrtashfar, Anna Finne-Wistrand, Daniela Pappalardo

{"title":"Dual-Responsive Nanoparticles for Smart Drug Delivery: A NIR Light-Sensitive and Redox-Reactive PEG-PCL-Based System.","authors":"Nancy Ferrentino, Taha Behroozi Kohlan, Shokoufeh Mehrtashfar, Anna Finne-Wistrand, Daniela Pappalardo","doi":"10.1021/acs.biomac.4c00889","DOIUrl":"10.1021/acs.biomac.4c00889","url":null,"abstract":"Stimuli-responsive polymeric nanoparticles (NPs) can serve as smart drug delivery systems (DDSs) by triggering drug release upon external or internal stimuli. A dual-responsive DDS made of a triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-SS-PEG-SS-PCL) copolymer, bearing disulfide bonds between PCL and PEG, was synthesized. The copolymer was functionalized with coumarin and sensitive to near-infrared (NIR) light irradiation, while the S-S bonds could be cleaved by GSH (10 mM). Characterization was achieved by nuclear magnetic resonance, size exclusion chromatography, and Fourier transform infrared analyses. Nile Red (NR)-loaded NPs were prepared through self-assembly of the copolymer in water and analyzed by dynamic light scattering and field-emission scanning electron microscopy. The NR release upon ultraviolet (UV)/NIR light irradiation as well as by GSH concentrations was monitored by using fluorescence spectroscopy, while simultaneous exposure to UV/NIR light and intracellular GSH concentration led to faster NR release. AlamarBlue assay showed satisfactory cell viability of the NR-loaded NPs, while their cellular uptake in human dermal fibroblast cells was investigated by fluorescence microscopy and fluorescence emission measurements.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"7660-7673"},"PeriodicalIF":5.5,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0