Biomacromolecules最新文献_第5页

Interface modifiable bacterial cellulose hydrogel based nerve guidance conduit effectively rehabilitate sciatic nerve injured rat. 界面改性细菌纤维素水凝胶神经引导导管可有效修复大鼠坐骨神经损伤。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-09 DOI: 10.1021/acs.biomac.5c00984

Disi Qiao, Nacun Yang, Lin Shi, Longyi Chen, Jun Gu, Xinhua Peng, Chuntao Chen, Dongping Sun

{"title":"Interface modifiable bacterial cellulose hydrogel based nerve guidance conduit effectively rehabilitate sciatic nerve injured rat.","authors":"Disi Qiao, Nacun Yang, Lin Shi, Longyi Chen, Jun Gu, Xinhua Peng, Chuntao Chen, Dongping Sun","doi":"10.1021/acs.biomac.5c00984","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00984","url":null,"abstract":"Peripheral nerve injury accounts for 2-5% of all trauma admissions worldwide and is a significant clinical challenge. In this research, a novel nerve guidance conduit biomaterial based on a tungsten oxide nanomaterial-decorated oxidized bacterial cellulose hydrogel was developed for repairing sciatic nerve injury. The bacterial cellulose was oxidized by sodium periodate, and aldehyde functional groups were introduced to enhance its reactivity and biocompatibility. At the same time, the incorporation of the tungsten oxide nanomaterial not only significantly improved its antibacterial properties but also rendered the material antioxidant. The functional recovery of the sciatic nerve in the rat transection model was assessed by the sciatic functional index, gastrocnemius histological analysis, and nerve histological analysis. This bacterial cellulose/tungsten oxide nanoparticle hybrid hydrogel biocomposite can effectively promote sciatic axon regeneration, Schwann cell activity, and nerve function recovery. This novel biocomposite provides a new therapeutic strategy for the repair of a sciatic nerve injury.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoupling Bioactivity and Processability: RGD Click-Functionalized Coatings for a 3D-Printed PCL Scaffold. 解耦生物活性和可加工性：3d打印PCL支架的RGD点击功能化涂层。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-09 DOI: 10.1021/acs.biomac.5c01691

Giulia Salsano, Carla Sardo, Angiola Guidone, Pierpaolo Coppola, Marina Sala, Maria Carmina Scala, Alessandra Soriente, Maria Grazia Raucci, Rita Patrizia Aquino, Giulia Auriemma

{"title":"Decoupling Bioactivity and Processability: RGD Click-Functionalized Coatings for a 3D-Printed PCL Scaffold.","authors":"Giulia Salsano, Carla Sardo, Angiola Guidone, Pierpaolo Coppola, Marina Sala, Maria Carmina Scala, Alessandra Soriente, Maria Grazia Raucci, Rita Patrizia Aquino, Giulia Auriemma","doi":"10.1021/acs.biomac.5c01691","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01691","url":null,"abstract":"The development of functionalized scaffolds with enhanced bioactivity remains a key challenge in bone tissue engineering (BTE). Here, we present a modular strategy to functionalize the surface of 3D-printed poly(ε-caprolactone) (PCL) scaffolds using an RGD-functionalized PCL derivative. A three-step synthesis introduced maleimide groups along the PCL backbone, enabling covalent conjugation of a thiol-containing peptide. The resulting polymer (PCL-AE-L) was applied via dip-coating, preserving the scaffold architecture and mechanical integrity while ensuring homogeneous surface coverage. Subsequent bioconjugation with the thiol-modified RGD peptide to obtain PCL@RGD scaffolds imparts enhanced cell-adhesive properties. Each functionalization step was confirmed by NMR, FTIR, DSC, GPC, and SEM-EDX analyses. Coating stability was demonstrated under simulated culture conditions. In vitro assays using SAOS-2 cells showed improved cell adhesion and mineralization of PCL@RGD compared to controls. This approach decouples bioactivity enhancement from the printing process and enables customizable surface functionalization, offering a versatile platform for developing next-generation scaffolds for regenerative medicine.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145256977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Chirality and Salt Addition on Phase Separation and Complexation Morphology in Mixtures of Polypeptides and Polypeptoids. 手性和加盐对多肽和多肽类混合物相分离和络合形态的影响。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01165

Kimiasadat Mirlohi, Anuja Thapa, Donghui Zhang, Whitney C Blocher McTigue

{"title":"The Effects of Chirality and Salt Addition on Phase Separation and Complexation Morphology in Mixtures of Polypeptides and Polypeptoids.","authors":"Kimiasadat Mirlohi, Anuja Thapa, Donghui Zhang, Whitney C Blocher McTigue","doi":"10.1021/acs.biomac.5c01165","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01165","url":null,"abstract":"Liquid-liquid phase separation (LLPS), particularly through coacervation, offers a groundbreaking approach to drug delivery by encapsulating therapeutic agents within phase-separated droplets, enhancing their stability, solubility, and controlled release. Polypeptides and polypeptoids, with their structural diversity and tunability, emerge as promising candidates for exploring these systems, with polypeptoids offering unique advantages, such as resistance to enzymatic degradation and increased control over interactions. This study examines the impact of chirality, mixing charge fraction, and salt concentration on the phase behavior and morphology of homochiral, mixed-chiral, and achiral polymers. By exploring the role of chirality and ionic strength in determining the presence and morphology of complexation, this research provides critical insights for designing tunable coacervate systems. Our results show that polypeptides and polypeptoids demonstrate chirality-dependent complexation. Additionally, we show that the presence and morphology of phase separation within these systems are influenced by the concentration of charged species in each sample, enabling the control and tunability of complex formation. These findings have the potential to advance the development of biomaterials for applications ranging from gene therapy to vaccine stabilization, offering innovative solutions to pressing biomedical challenges.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Asymmetric Janus Electrospun Nanofiber Wound Dressing Infused with Antibacterial and Anti-inflammatory Properties. 非对称Janus静电纺纳米纤维伤口敷料注入抗菌和抗炎性能。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01166

Jing Zhao, Na Liu, Yating Zeng, Yiwen Zhang, Liyun Chen, Jianda Zhou, Bo Liu, Wancong Zhang, Shijie Tang

{"title":"Asymmetric Janus Electrospun Nanofiber Wound Dressing Infused with Antibacterial and Anti-inflammatory Properties.","authors":"Jing Zhao, Na Liu, Yating Zeng, Yiwen Zhang, Liyun Chen, Jianda Zhou, Bo Liu, Wancong Zhang, Shijie Tang","doi":"10.1021/acs.biomac.5c01166","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01166","url":null,"abstract":"Infection, sustained inflammation, and angiogenesis disorders delay skin wound healing. Consequently, there is a substantial demand for bioactive wound dressings that exhibit antibacterial properties, modulate inflammation, and facilitate wound healing. In this study, we developed a double-layer bioactive Janus electrospun nanofiber (ESF) dressing endowed with antibacterial and anti-inflammatory capabilities. The beaded hydrophobic outer layer acts as a physical barrier, preventing external fluids from contaminating the dressing and discouraging microbial attachment and growth. In contrast, the coaxial hydrophilic inner layer supports cell adhesion and migration. The results of the CCK-8 test and in vitro scratch wound healing assay of fibroblasts and endothelial cells demonstrated that the polycaprolactone/phycocyanin/chitosan/poly(ethylene oxide)/ε-poly-l-lysine Janus ESF dressing increased cell viability and migration. The RAW264.7 macrophage phenotypic switching assay results indicated the anti-inflammatory effects of the dressing. The dressing also exhibited a satisfactory antibacterial effect. Herein, the bioactive Janus ESF dressing hold considerable promise for wound healing.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A ROS-Scavenging and Conductive Hydrogel-Based Cardiac Patch with Controlled Release of Edaravone for Myocardial Infarction Treatment Assisted by Electrical Stimulation. 一种具有依达拉奉控释的ros清除导电水凝胶心脏贴片用于电刺激辅助心肌梗死治疗。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01395

Shiyu Wang, Xueshan Zhao, Yujia Zhan, Jiaqiao Liang, Jianyang Shi, Jun Gu, Haibo Wang

引用次数: 0

Preparation of Silk Fibroin Nanofibers/Nanocrystals through TEMPO/Laccase/O₂ Oxidation. TEMPO/漆酶/O2氧化法制备丝素纳米纤维/纳米晶体。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01221

Huangjingyi Chen, Yue Ma, Tian Huang, Liang Liu, Juan Yu, Ruoxian Jia, Meijuan Chen, Lin Lin, Xin Li, Zhiguo Wang, Yimin Fan

{"title":"Preparation of Silk Fibroin Nanofibers/Nanocrystals through TEMPO/Laccase/O2 Oxidation.","authors":"Huangjingyi Chen, Yue Ma, Tian Huang, Liang Liu, Juan Yu, Ruoxian Jia, Meijuan Chen, Lin Lin, Xin Li, Zhiguo Wang, Yimin Fan","doi":"10.1021/acs.biomac.5c01221","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01221","url":null,"abstract":"Nanomaterial-based hydrogels derived from natural silk have garnered significant attention in advanced applications. However, preparation of silk fibroin nanofibers by directly disintegrating natural silk fibers remains challenging. We initiated the process by employing various pretreatment methods to loosen the intricate structure of the natural silk fibers. Subsequently, carboxyl groups were introduced to the silk fibroin surface using a sequential TEMPO/Laccase/O2 (TLO) oxidation approach, whereby the fabrication of silk nanofibers (TLO-SNFs) or nanocrystals (TLO-SNCs) was achieved with a high carboxyl content (ranging from 0.795 to 0.935 mmol/g) and nanofiber lengths of up to 1843 ± 659 nm. Furthermore, TLO-SNFs were further incorporated with poly(N-isopropylacrylamide) (PNIPAm) through acetic acid coagulation, whereby a reinforced TLO-SNF@PNIPAm hydrogel was constructed with an interpenetrating network. It exhibited excellent mechanical performance and demonstrated shape-retaining shrinkage-expansion capabilities, significantly extending the release time of curcumin to 2 weeks. This makes TLO-SNF@PNIPAm an ideal carrier for the long-term in vitro release of curcumin, offering potential applications in responsive transdermal patches.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rational Design of DNA Nanostructures as TLR9 Agonists. TLR9激动剂DNA纳米结构的合理设计。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c00919

Chunfa Chen, Cheng Tian, Zhuoer Jin, Yuandong Wen, Xiaoyu Xia, Qiao Ren, Cheng Zhi Huang, Hua Zuo

引用次数: 0

Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management. 集成光热转换、自我修复、生物粘附和抗菌活性的智能分层水凝胶结构用于下一代伤口管理。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01030

Wei Jiang, Zhen Weng, Yue Yin, Changling Liu, Siqi Zhan, Li Sheng, Yan Fu, Hong Yu Yang

{"title":"Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management.","authors":"Wei Jiang, Zhen Weng, Yue Yin, Changling Liu, Siqi Zhan, Li Sheng, Yan Fu, Hong Yu Yang","doi":"10.1021/acs.biomac.5c01030","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01030","url":null,"abstract":"Effective wound management remains a significant challenge in healthcare, necessitating advanced materials that can address multiple limitations of wound healing simultaneously. Herein, we developed a novel mfp5-inspired and multicross-linked hydrogel (DAPEG/GAEPL@TA/Fe) incorporating dibenzaldehyde-terminated polyethylene glycol, ε-poly-l-lysine, gallic acid, tannic acid, and Fe3+ ions. Physicochemical properties of the hydrogel, antibacterial efficacy, hemostatic capabilities, and wound healing performance were extensively assessed by means of in vitro and in vivo investigations. The DAPEG/GAEPL@TA/Fe hydrogel demonstrated strong wet adhesion, excellent mechanical properties, and self-healing capabilities. Its antibacterial efficacy was enhanced by photothermal conversion under NIR irradiation, effectively inhibiting both Gram-positive and Gram-negative bacteria. The hydrogel showed remarkable hemostatic performance in mouse models and significantly accelerated wound healing in vivo, with enhanced collagen deposition and reduced inflammation. The multifunctional DAPEG/GAEPL@TA/Fe hydrogel embodies a breakthrough in wound dressing materials, offering a comprehensive solution for complex wound management challenges. Its unique combination of properties and demonstrated efficacy suggest promising potential for clinical utilization in wound management and tissue regeneration.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Zwitterionic Conductive Hydrogel Interface for Enhanced Electrocorticography Signal Fidelity via High Conductivity, Antifouling, and Brain-Matched Mechanics. 两性离子导电水凝胶界面通过高电导率、防污和脑匹配力学增强皮质电成像信号保真度。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-07 DOI: 10.1021/acs.biomac.5c01412

Ying Xiang, Xuan He, Tingting Cheng, Weihao Zhu, Ji Pang, Yijia Cao, Meng Wu, Renjun Pei, Yi Cao

{"title":"A Zwitterionic Conductive Hydrogel Interface for Enhanced Electrocorticography Signal Fidelity via High Conductivity, Antifouling, and Brain-Matched Mechanics.","authors":"Ying Xiang, Xuan He, Tingting Cheng, Weihao Zhu, Ji Pang, Yijia Cao, Meng Wu, Renjun Pei, Yi Cao","doi":"10.1021/acs.biomac.5c01412","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01412","url":null,"abstract":"Electrocorticography (ECoG) holds considerable promise for neural signal monitoring with high spatiotemporal resolution. However, conventional rigid ECoG electrodes are often hampered by poor mechanical compliance and insufficient resistance to biofouling, leading to high interfacial impedance and compromised signal quality. While integrating conductive hydrogels into ECoG interface offers a potential solution, concurrently achieving high conductivity, mechanical compatibility with brain tissue, biosafety, and robust antifouling remains a significant challenge. This study introduces SPP@NaCl, a novel zwitterionic conductive hydrogel synthesized by doping a poly(sulfobetaine methacrylate) (pSB) hydrogel matrix with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and employing NaCl as a Lewis acid to induce phase separation, thereby promoting an interconnected PEDOT network. The resultant SPP@NaCl hydrogel exhibits a compelling combination of properties: high electrical conductivity (∼9 S·m-1), a low Young's modulus (1.74 kPa) that closely matches brain tissue, excellent conformability, and markedly reduced protein adsorption attributable to its zwitterionic structure. When integrated with commercial ECoG electrodes, the optimized SPP@NaCl-8 hydrogel dramatically lowers interfacial impedance. The resulting Au-SPP@NaCl electrodes enabled high-fidelity, real-time monitoring of cortical epileptiform discharges in a rat seizure model and demonstrated stable, long-term neural signal acquisition in anesthetized healthy rats. This work presents a new strategy for constructing ECoG interfaces that simultaneously deliver high conductivity, mechanical compliance, biosafety, and antifouling capabilities, highlighting the significant potential of these hydrogel-integrated ECoG electrodes for advanced brain-computer interface applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Density of Mono- and Trivalent High-Mannan-Derived Targeting Structures with Different Affinities Impacts Cellular Uptake of Human Serum Albumin-Derived Nanocarriers. 具有不同亲和力的单价和三价高甘露聚糖衍生靶向结构的表面密度影响人血清白蛋白衍生纳米载体的细胞摄取。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-07 DOI: 10.1021/acs.biomac.5c01510

Robert Forster, Bellinda Lantzberg, Annabelle Weldert, Laura Rosenberger, Yanira Zeyn, Danuta Kowalczyk, Seah Ling Kuan, Christian Kersten, Matthias Bros, Tanja Weil, Tanja Schirmeister, Till Opatz

{"title":"Surface Density of Mono- and Trivalent High-Mannan-Derived Targeting Structures with Different Affinities Impacts Cellular Uptake of Human Serum Albumin-Derived Nanocarriers.","authors":"Robert Forster, Bellinda Lantzberg, Annabelle Weldert, Laura Rosenberger, Yanira Zeyn, Danuta Kowalczyk, Seah Ling Kuan, Christian Kersten, Matthias Bros, Tanja Weil, Tanja Schirmeister, Till Opatz","doi":"10.1021/acs.biomac.5c01510","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01510","url":null,"abstract":"Actively targeted delivery of nanocarriers (NC) modified with targeting structures (TS) binding to cell surface receptors, specific to target cells, enables enhanced selectivity and efficacy of cellular uptake. This is influenced by the ligand density on the NC surface. Herein, the impact of type, valency, and surface density of high-mannan derived TS on the C-type lectin receptor (CLR)-mediated uptake of human serum albumin (HSA)-based NCs in immune cell populations was investigated. Monovalent and trivalent TSs were prepared via efficient synthesis protocols and investigated regarding their affinity versus isolated carbohydrate recognition domains (CRD) of CD206 and CD209 within a NanoDSF study. Conjugation to HSA resulted in low valency and saturated NCs with a well-defined mannose epitope count. An in vitro study with bone-marrow-derived dendritic cells and splenic immune cells revealed the impact of the NC surface modification on cellular uptake and cell selectivity, allowing insights into the design of TSs and NCs.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0