Biomacromolecules最新文献

筛选
英文 中文
A Hydrogel Implantable Supercapacitor with Tissue-Adhesive Using PEDOT:PSS as Active Material 以PEDOT:PSS为活性材料的组织胶粘剂水凝胶植入式超级电容器。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00300
Suting Zhou, Meimei Yu, Yumeng Wang, Yuxia Zhang, Xiangya Wang, Fen Ran
{"title":"A Hydrogel Implantable Supercapacitor with Tissue-Adhesive Using PEDOT:PSS as Active Material","authors":"Suting Zhou,&nbsp;Meimei Yu,&nbsp;Yumeng Wang,&nbsp;Yuxia Zhang,&nbsp;Xiangya Wang,&nbsp;Fen Ran","doi":"10.1021/acs.biomac.5c00300","DOIUrl":"10.1021/acs.biomac.5c00300","url":null,"abstract":"<div><div>Implantable biomedical supercapacitors represent a critical advancement in modern biomedical engineering, offering an optimal power solution for implantable medical devices due to their exceptional characteristics. However, achieving supercapacitors that concurrently exhibit tissue adhesiveness and biocompatibility remains a significant research challenge. In this study, the DMSO post-treatment method is employed to enhance the condensed state structure of the conductive polymer PEDOT:PSS, which results in a significant improvement in the electrochemical performance of the supercapacitor embedded within the poly­(acrylic acid) hydrogel matrix. This supercapacitor demonstrates a capacity retention rate of 97.81% after 10 000 charging–discharging cycles. Additionally, it exhibits favorable mechanical properties (tensile strain of 233%) and strong tissue adhesiveness (viscous frictional stress of 6.42 kPa). Following implantation in mice, this device also exhibits excellent biocompatibility. These findings suggest that this technology can significantly advance the energy supply for microintelligent medical devices.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (129KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4297-4307"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Self-Assembled Keratin Nanoparticles Prepared by Partial Hydrolysis and Their Restructuring Response to pH Shifting for Biomolecule Encapsulation 部分水解制备自组装角蛋白纳米颗粒及其对pH变化的重组响应。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.4c01773
Xiaojie Qin , Yi Zhang , Changyan Zhang , Yujie Guo , Johannes H. Bitter , Chunhui Zhang , Elinor L. Scott
{"title":"Self-Assembled Keratin Nanoparticles Prepared by Partial Hydrolysis and Their Restructuring Response to pH Shifting for Biomolecule Encapsulation","authors":"Xiaojie Qin ,&nbsp;Yi Zhang ,&nbsp;Changyan Zhang ,&nbsp;Yujie Guo ,&nbsp;Johannes H. Bitter ,&nbsp;Chunhui Zhang ,&nbsp;Elinor L. Scott","doi":"10.1021/acs.biomac.4c01773","DOIUrl":"10.1021/acs.biomac.4c01773","url":null,"abstract":"<div><div>Keratin, an abundant biopolymer in animal byproducts, holds promise as a biomolecule delivery carrier due to its biocompatibility, biodegradability, and low toxicity. However, its intrinsic stability from disulfide bonds limits broader application. Here, we present a strategy to convert waste feather keratin into keratin nanoparticles (KNPs) via partial hydrolysis and pH shifting. At 5% degree of hydrolysis (DH), keratin self-assembled into spherical KNPs with reduced size (∼123 nm) and enhanced solubility (94.5%). These KNPs displayed pH-triggered structural transitions (open state at pH 2.0 → closed at pH 7.0) and high loading efficiency (&gt;93%) for insulin and resveratrol, offering partial protection against gastrointestinal enzymatic degradation and low cytotoxicity. In contrast, higher DH (≥10%) increased β-sheet content and hydrophobic exposure, promoting KNP aggregation and lowering their pH responsiveness and biomolecule encapsulation. Our findings demonstrate the potential of 5% DH KNPs as nanocarriers, providing a sustainable approach for nutrient and pharmaceutical applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (177KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4027-4039"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G‑Quadruplexes 分子拥挤对形成多个g -四联体的端粒悬垂可及性的影响。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00360
Golam Mustafa, Sajad Shiekh, Janan Alfehaid, Sineth G. Kodikara, Hamza Balci
{"title":"Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G‑Quadruplexes","authors":"Golam Mustafa,&nbsp;Sajad Shiekh,&nbsp;Janan Alfehaid,&nbsp;Sineth G. Kodikara,&nbsp;Hamza Balci","doi":"10.1021/acs.biomac.5c00360","DOIUrl":"10.1021/acs.biomac.5c00360","url":null,"abstract":"<div><div>Molecular crowdinga defining feature of the cellular environmentaffects folding kinetics, conformation, and stability of G-quadruplex (GQ) structures. However, its influence on the overall architecture and accessibility of telomeric overhangs containing multiple GQs remains largely unexplored. In this study, we employed single-molecule FRET and FRET-PAINT to address this question. We examined the accessibility of telomeric overhangs, capable of forming 1–6 GQs, to a short complementary peptide nucleic acid (PNA) imager probe in the presence of 200 and 6000 Da polyethylene glycol (PEG) molecules (PEG-200 and PEG-6000). We observed a progressive compaction and architectural condensation of the overhang as PEG concentration increased. At 30% concentration, this compaction was accompanied by approximately 3-fold and 8-fold reduction in probe accessibility in PEG-200 and PEG-6000, respectively. These findings offer new insights into how the crowded cellular environment may compact telomeric overhangs and modulate their structural and functional properties.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (79KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4380-4386"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Bioadhesive Functional Peptide-Derived Supramolecular Hydrogel for the Promotion of Corneal Re-Epithelization 促进角膜再上皮形成的生物粘附功能肽衍生的超分子水凝胶。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00221
Lei Lei , Jia Liu , Yueting Shi, Yiping Wu, Wei Wu, Yuhan Hu, Haoxuan Wang, Jiaqing Wang, Xingyi Li
{"title":"A Bioadhesive Functional Peptide-Derived Supramolecular Hydrogel for the Promotion of Corneal Re-Epithelization","authors":"Lei Lei ,&nbsp;Jia Liu ,&nbsp;Yueting Shi,&nbsp;Yiping Wu,&nbsp;Wei Wu,&nbsp;Yuhan Hu,&nbsp;Haoxuan Wang,&nbsp;Jiaqing Wang,&nbsp;Xingyi Li","doi":"10.1021/acs.biomac.5c00221","DOIUrl":"10.1021/acs.biomac.5c00221","url":null,"abstract":"<div><div>The rapid corneal re-epithelization after injury is crucial for maintaining corneal homeostasis and barrier function. This study reports a bioadhesive functional peptide-derived supramolecular hydrogel (FBA-FFGGRGD) for promoting corneal re-epithelization. The aldehyde-modified bioactive peptide (RGD) endows the hydrogel with bioadhesive properties, enabling covalent anchoring to corneal basement membrane proteins via Schiff base reaction. Compared with its analogue (TA-FFGGRGD), FBA-FFGGRGD significantly enhances adhesion, migration, and proliferation of human corneal epithelial cells (HCECs), doubling cell numbers within 48 h and upregulating zonula occludens-1 (ZO-1) expression. <em>In vivo</em> studies show that the hydrogel exhibits excellent ocular biocompatibility, prolongs precorneal retention (∼40 min), and promotes stratified epithelium formation in a rabbit model of corneal injury. By remodeling the epithelial barrier, this bioadhesive hydrogel provides a promising strategy for corneal homeostasis preservation and ocular disorder prevention.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (193KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4219-4229"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spider Silk-Inspired Flexible Biomacromolecular Composite with Electrical and Thermal Functionality from Mesoporous Bamboo 由介孔竹子制成的具有电和热功能的蜘蛛丝启发的柔性生物大分子复合材料。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00537
Tianfang Zhang , Luxi He , Xiangyu Zhao , Wenrui Xie , Zhengbin He , Zhenyu Wang , Songlin Yi
{"title":"Spider Silk-Inspired Flexible Biomacromolecular Composite with Electrical and Thermal Functionality from Mesoporous Bamboo","authors":"Tianfang Zhang ,&nbsp;Luxi He ,&nbsp;Xiangyu Zhao ,&nbsp;Wenrui Xie ,&nbsp;Zhengbin He ,&nbsp;Zhenyu Wang ,&nbsp;Songlin Yi","doi":"10.1021/acs.biomac.5c00537","DOIUrl":"10.1021/acs.biomac.5c00537","url":null,"abstract":"<div><div>Inspired by the hierarchical architecture of spider silk, this study introduces a biobased macromolecular composite that combines mechanical flexibility, thermal regulation, and electrical performance. The composite is constructed using a delignified bamboo scaffold, which acts as a naturally aligned, mesoporous framework of cellulose-based macromolecules, integrated with carboxylated multiwalled carbon nanotubes and poly (vinyl alcohol). This design yields a mechanically resilient macromolecular network with stable electrical conductivity under cyclic deformation. The composite achieves enhanced thermal conductivity and demonstrates a 7.29% increase in ice-melting efficiency. Importantly, under prolonged thermal exposure, the composite undergoes thermal degradation, forming a protective carbonaceous char layer that suppresses combustion and reduces CO<sub>2</sub> and particulate emissions by 37.2 and 84.6%, respectively. The intrinsic mesoporous structure of bamboo provides an ultralight yet robust template, maintaining mechanical integrity even under cyclic stress. Additionally, the conductive nanomaterials improve interfacial properties, making this composite a promising candidate for durable, biobased flexible electronics and thermally stable structural applications. These multifunctional characteristics highlight the potential of natural macromolecular architectures in developing sustainable, biodegradable, and high-performance polymeric systems for flexible electronics and thermally stable applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (179KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4544-4557"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14
Ayan Dutta,  and , William M. Gramlich*, 
{"title":"","authors":"Ayan Dutta,&nbsp; and ,&nbsp;William M. Gramlich*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00142","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14
Kiseok Han, Anbazhagan Sathiyaseelan and Myeong-Hyeon Wang*, 
{"title":"","authors":"Kiseok Han,&nbsp;Anbazhagan Sathiyaseelan and Myeong-Hyeon Wang*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00045","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14
Maolin Li, Hui Yan, Tong Li, Yin Liu, Haiping Zhang*, Dandan Han*, Songgu Wu* and Junbo Gong, 
{"title":"","authors":"Maolin Li,&nbsp;Hui Yan,&nbsp;Tong Li,&nbsp;Yin Liu,&nbsp;Haiping Zhang*,&nbsp;Dandan Han*,&nbsp;Songgu Wu* and Junbo Gong,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14
Shaghayegh Vakili, Hamed Azadfar, Ebrahim Ahmadi*, Zahra Mohamadnia*, Atiyeh Mahdavi and Faezeh Hanifeh, 
{"title":"","authors":"Shaghayegh Vakili,&nbsp;Hamed Azadfar,&nbsp;Ebrahim Ahmadi*,&nbsp;Zahra Mohamadnia*,&nbsp;Atiyeh Mahdavi and Faezeh Hanifeh,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00346","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-07-14
{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/bmv026i007_1958027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144613550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信