Biomacromolecules最新文献_第5页

Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy. 可切换纳米光敏剂作为焦亡诱导剂靶向增强抗肿瘤光免疫治疗。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-08 DOI: 10.1021/acs.biomac.5c00140

Xiaoxi Zhao, Qinjie Zhong, Naibijiang Abudouaini, Yan Zhao, Jibin Zhang, Guozhu Tan, Guifeng Miao, Xiaowu Wang, Jianqiang Liu, Ying Pan, Xiaorui Wang

{"title":"Switchable Nanophotosensitizers as Pyroptosis Inducers for Targeted Boosting of Antitumor Photoimmunotherapy.","authors":"Xiaoxi Zhao, Qinjie Zhong, Naibijiang Abudouaini, Yan Zhao, Jibin Zhang, Guozhu Tan, Guifeng Miao, Xiaowu Wang, Jianqiang Liu, Ying Pan, Xiaorui Wang","doi":"10.1021/acs.biomac.5c00140","DOIUrl":"10.1021/acs.biomac.5c00140","url":null,"abstract":"Photodynamic therapy (PDT) has emerged as a promising modality for cancer treatment, but its clinical application is constrained by unexpected phototoxicity arising from nonspecific photosensitizer activation and their \"always-on\" nature. Herein, we developed a switchable nanophotosensitizer, poly(cation-π) nanoparticles (NP), which achieves supramolecular assembly through cation-π interactions. By coupling choline cationic moieties with aromatic photosensitizers (ZnPc), the polymer facilitates self-assembly driven by cation-π interactions for NP engineering. Surprisingly, the photoactivity of ZnPc was completely quenched upon complexation via cation-π interactions, thereby significantly avoiding skin phototoxicity. Upon targeting tumor cells, NP undergoes a GSH-responsive degradation process that weakens cation-π interactions, leading to spontaneous restoration of photoactivity and amplifying tumor immunogenic pyroptosis. In vivo studies demonstrated that NP achieved a high tumor inhibition rate of 84% while effectively avoiding skin phototoxicity. This work provides a novel perspective for enhancing the safety and efficacy of PDT-based tumor treatment.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"3065-3083"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D-Printed Auxetic Ionic Hydrogels with Moisture Retention and High Sensitivity for Sustainable Wearable Sensing. 3d打印的辅助离子水凝胶，具有保湿性和高灵敏度，用于可持续的可穿戴传感。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-11 DOI: 10.1021/acs.biomac.5c00238

Lanlan Dong, Yi Ru, Xinxin Gao, Ru Jia, Jing Wang, Wurikaixi Aiyiti, Cijun Shuai

{"title":"3D-Printed Auxetic Ionic Hydrogels with Moisture Retention and High Sensitivity for Sustainable Wearable Sensing.","authors":"Lanlan Dong, Yi Ru, Xinxin Gao, Ru Jia, Jing Wang, Wurikaixi Aiyiti, Cijun Shuai","doi":"10.1021/acs.biomac.5c00238","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00238","url":null,"abstract":"Conductive hydrogels face challenges in maintaining environmental and mechanical stability for practical sensor applications. In this study, a long-term, stable, and highly sensitive ionically conductive hydrogel was developed via a synergistic dual-humectant strategy: glycerol suppressed ice nucleation through hydrogen-bond competition, while LiCl provided dynamic water sorption. This synergy enables unprecedented stability─remaining unfrozen at -60 °C and retaining 70% moisture over 35 days at 25 °C. The hydrogel exhibits exceptional stretchability (1270% strain) and adhesion (60 kPa) through combined physical/covalent interactions. A three-dimensional (3D)-printed porous architecture enhances sensitivity, achieving a gauge factor of 32 (3 × higher than nonporous hydrogel). In particular, the auxetic-structured conductive hydrogel─when used as a wearable device─demonstrated an accurate recognition ability in detecting limb and subtle movements (including speech). These properties position the hydrogels as promising candidates for fabricating flexible wearable sensors with enhanced sensitivity and environmental sustainability.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"3155-3166"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomass-Based Functional Composite Resins with Recyclable and Shape Memory Properties. 具有可回收和形状记忆性能的生物质基功能复合树脂。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-21 DOI: 10.1021/acs.biomac.4c01814

Shenglong Liao, Shuying Zhong, Can Sun, Zhiyong Liu, Daxiang Gui, Puyou Jia, Ying Lin

{"title":"Biomass-Based Functional Composite Resins with Recyclable and Shape Memory Properties.","authors":"Shenglong Liao, Shuying Zhong, Can Sun, Zhiyong Liu, Daxiang Gui, Puyou Jia, Ying Lin","doi":"10.1021/acs.biomac.4c01814","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01814","url":null,"abstract":"A key challenge in developing advanced functional thermosets lies in designing molecular architectures capable of integrating different specific performances into one material to meet diverse application demands. Here, a chitosan-derived trifunctional compound containing maleimide groups was used to directly cross-link tung oil-based polymer for fabricating multifunctional composite bioresins with reversible Diels-Alder bonds. The reversible cross-linking networks within resins were featured with stress relaxation, thermal reprocessability, and recyclability. The retro D-A reaction at relatively high temperatures provided the dynamic characteristics of the resins while ensuring their dimensional stability. Moreover, chitosan enhanced the mechanical properties of the resins while forming supramolecular hydrogen bonds via its abundant amino/hydroxyl groups, realizing shape memory of the resins. Furthermore, the synergistic interaction between chitosan functional groups and hydrogen bonding also imparted proton conductivity to the resins. This work provided a molecular design paradigm that harmonizes multifunctional integration in fully biomass resins, aiming for high-value applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"2922-2933"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery. 使用巯基烯水凝胶进行双重药物递送的局部癌症治疗。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-08 DOI: 10.1021/acs.biomac.5c00387

Lakshmi Sathi Devi, Maria Rosa Gigliobianco, Serena Gabrielli, Dimitrios Agas, Maria Giovanna Sabbieti, Maria Beatrice Morelli, Consuelo Amantini, Cristina Casadidio, Piera Di Martino, Roberta Censi

{"title":"Localized Cancer Treatment Using Thiol-Ene Hydrogels for Dual Drug Delivery.","authors":"Lakshmi Sathi Devi, Maria Rosa Gigliobianco, Serena Gabrielli, Dimitrios Agas, Maria Giovanna Sabbieti, Maria Beatrice Morelli, Consuelo Amantini, Cristina Casadidio, Piera Di Martino, Roberta Censi","doi":"10.1021/acs.biomac.5c00387","DOIUrl":"10.1021/acs.biomac.5c00387","url":null,"abstract":"Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized by varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% or 33%). Rheological analysis confirmed enhanced viscoelasticity with increasing molecular weight and modification (99Gel-33 > 99Gel-16 > 23Gel-33 > 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) and carvacrol (CRV), exhibiting tumor-responsive degradation and tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% in PBS), while CRV showed an initial burst followed by sustained release. The hydrogel promoted mesenchymal stem cell proliferation and effectively inhibited triple-negative breast cancer cells. This injectable, tumor-responsive hydrogel system offers a promising platform for minimally invasive, personalized cancer therapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"3234-3254"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Autonomous Abiotic Thermal Protectant for Immunoglobulin G: Reducing the Need for Cold Chain Storage. 免疫球蛋白G的自主非生物热保护剂：减少冷链储存的需要。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-07 DOI: 10.1021/acs.biomac.4c01492

Beverly Chou, Rishad J Dalal, Kenneth J Shea

引用次数: 0

Analysis of the Growth Mechanism of Eumelanin Particles by Time-Resolved Static and Dynamic Light Scattering. 真黑素颗粒生长机制的时间分辨静态和动态光散射分析。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-11 DOI: 10.1021/acs.biomac.5c00158

Fabian Kollmann, Anne Büngeler, Miriam Splett, Oliver I Strube, Klaus Huber

引用次数: 0

A Facile and Versatile Platform for Cytosolic Delivery of Proteins in Nanoshells of DNA or RNA: Packaging Options in Multiplexed Delivery. 在DNA或RNA的纳米壳中递送蛋白质的一个简单和通用的细胞质递送平台：多路递送的包装选择。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-05-01 DOI: 10.1021/acs.biomac.5c00149

Pilar O'Neal, Kareem Washington, Bram Estes, Preethi L Chandran

引用次数: 0

A Dual-Interaction Supramolecular Hydrogel System for siRNA Delivery to Enhance Endometrial Receptivity in Stem Cell Therapy. 用于siRNA递送的双相互作用超分子水凝胶系统在干细胞治疗中增强子宫内膜容受性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-25 DOI: 10.1021/acs.biomac.5c00132

Xiaowei Zhang, Yongping Lu, Liqun Yang, Yu Sui, Chong Zhang, Wei Zhang, Jing Guo, Keke Wang, Xiaoliang Liu, Meina Lin

{"title":"A Dual-Interaction Supramolecular Hydrogel System for siRNA Delivery to Enhance Endometrial Receptivity in Stem Cell Therapy.","authors":"Xiaowei Zhang, Yongping Lu, Liqun Yang, Yu Sui, Chong Zhang, Wei Zhang, Jing Guo, Keke Wang, Xiaoliang Liu, Meina Lin","doi":"10.1021/acs.biomac.5c00132","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00132","url":null,"abstract":"Endometrial receptivity is crucial for embryo implantation success. Stem cell therapy shows promise for improving endometrial health. We developed a supramolecular hydrogel scaffold based on stereocomplexed triblock copolymers (MPEG-(sc-PLA)-PEI) and α-cyclodextrin for codelivering menstrual blood-derived endometrial stem cells (MenSCs) and siRNA targeting DNA methyl transferase 1 (DNMT1), enabling RNAi-mediated gene silencing to improve endometrial receptivity. The resulting α-CD/MPEG-(sc-PLA)-PEI hydrogels exhibited high mechanical stability, excellent self-healing capabilities, and sustained siRNA release via a dual-interaction mechanism involving host-guest interaction and stereocomplexation. In vitro studies indicated superior cellular uptake of DNMT1 siRNA encapsulated within MPEG-(sc-PLA)-PEI complexes, resulting in significant upregulation of endometrial receptivity markers, including HOXA10, ITGB3, and E-cadherin. In vivo experiments showed that DNMT1 siRNA-loaded hydrogels facilitated endometrial remodeling through therapeutic transgene expression in MenSCs. These findings suggest that this multifunctional hydrogel system may serve as an effective tool for stem cell-based therapies aimed at enhancing endometrial receptivity.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"3044-3058"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semaglutide Aggregates into Oligomeric Micelles and Short Fibrils in Aqueous Solution. 半聚脲在水溶液中聚集成低聚胶束和短纤维。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 DOI: 10.1021/acs.biomac.5c00342

Ian W Hamley, Lucas R de Mello, Valeria Castelletto, Thomas Zinn, Nathan Cowieson, Jani Seitsonen, Thomas Bizien

引用次数: 0

pH-Responsive Hyperbranched Polymer Scaffolds for Polymer and Peptide Conjugation through Molecular Recognition: Synthesis and Self-Assembly. 通过分子识别进行聚合物和肽偶联的ph响应型超支化聚合物支架：合成和自组装。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-05-12 Epub Date: 2025-04-15 DOI: 10.1021/acs.biomac.5c00041

Yue Zhang, Liyuan Tian, Jimin Zhang, Meihui Zhong

{"title":"pH-Responsive Hyperbranched Polymer Scaffolds for Polymer and Peptide Conjugation through Molecular Recognition: Synthesis and Self-Assembly.","authors":"Yue Zhang, Liyuan Tian, Jimin Zhang, Meihui Zhong","doi":"10.1021/acs.biomac.5c00041","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00041","url":null,"abstract":"Hyperbranched polymers can be suitable polymeric scaffolds for the modification of functional groups and fabrication of applicable nanoparticles considering their good solubility, numerous modification sites, and unique self-assembly behaviors. To facilitate the modification process and obtain various functional hyperbranched polymers, a new inimer 2-((adamantan-1-yl)amino)-1-(4-((2-bromo-2-methylpropanoyl)oxy)phenyl)-2-oxoethyl methacrylate (ABMA) with an adamantyl group was prepared in this research through the Passerini reaction. ABMA was copolymerized with 2-(diisopropylamino)ethyl methacrylate (DPA), affording the pH-responsive hyperbranched polymer hPDPA. Model molecules poly(ethylene glycol) (PEG) and the peptide RRRRRRRRC (PArg) with a cell-penetrating octaarginine fragment were conjugated with β-cyclodextrin (β-CD) to modify the hPDPA through molecular recognition. The inclusion complex hPDPA/PEG self-assembled into micelles in phosphate buffer at pH 7.4, while hPDPA/PEG/PArg self-assembled into vesicles because of the repulsion of the positively charged PArg. It was demonstrated that the DOX-loaded hPDPA/PEG/PArg could be internalized by Hela cells with high efficiency and could induce apoptosis of Hela cells.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 5","pages":"2960-2970"},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0