Biomacromolecules最新文献

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Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G-Quadruplexes. 分子拥挤对形成多个g -四联体的端粒悬垂可及性的影响。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-13 DOI: 10.1021/acs.biomac.5c00360
Golam Mustafa, Sajad Shiekh, Janan Alfehaid, Sineth G Kodikara, Hamza Balci
{"title":"Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G-Quadruplexes.","authors":"Golam Mustafa, Sajad Shiekh, Janan Alfehaid, Sineth G Kodikara, Hamza Balci","doi":"10.1021/acs.biomac.5c00360","DOIUrl":"10.1021/acs.biomac.5c00360","url":null,"abstract":"<p><p>Molecular crowding─a defining feature of the cellular environment─affects folding kinetics, conformation, and stability of G-quadruplex (GQ) structures. However, its influence on the overall architecture and accessibility of telomeric overhangs containing multiple GQs remains largely unexplored. In this study, we employed single-molecule FRET and FRET-PAINT to address this question. We examined the accessibility of telomeric overhangs, capable of forming 1-6 GQs, to a short complementary peptide nucleic acid (PNA) imager probe in the presence of 200 and 6000 Da polyethylene glycol (PEG) molecules (PEG-200 and PEG-6000). We observed a progressive compaction and architectural condensation of the overhang as PEG concentration increased. At 30% concentration, this compaction was accompanied by approximately 3-fold and 8-fold reduction in probe accessibility in PEG-200 and PEG-6000, respectively. These findings offer new insights into how the crowded cellular environment may compact telomeric overhangs and modulate their structural and functional properties.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Distribution of Substitution on Marine Biodegradability for Paramylon Acetate and Cellulose Acetate. 取代分布对醋酸Paramylon和醋酸纤维素海洋生物降解性的影响。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-13 DOI: 10.1021/acs.biomac.5c00252
Ruiqi Li, Jin Ho Seok, Tadahisa Iwata
{"title":"Effect of Distribution of Substitution on Marine Biodegradability for Paramylon Acetate and Cellulose Acetate.","authors":"Ruiqi Li, Jin Ho Seok, Tadahisa Iwata","doi":"10.1021/acs.biomac.5c00252","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00252","url":null,"abstract":"<p><p>Paramylon acetate and cellulose acetate with different degrees and distributions of substituents were synthesized by two different methods, de-esterification from triesters with NaOH treatment and direct esterification. Paramylon and cellulose acetate obtained by de-esterification exhibited a lower degree of substitution (DS) at C6 and a higher DS at C2 position. All of the acetate samples with different DSs were thermoformable, producing transparent films. However, melt-pressed films obtained through de-esterification exhibited greater flexibility than those prepared via direct esterification. Simultaneously, biochemical oxygen demand (BOD) tests demonstrated that paramylon and cellulose acetate obtained by de-esterification show higher biodegradability than esterification ones with the same DS. This increased biodegradability may be attributed to the lower DS of the acetyl group on C6 for paramylon and cellulose acetate obtained by de-esterification. De-esterification with NaOH treatment was validated as an effective approach for producing polysaccharide esters with excellent mechanical properties and biodegradability for both paramylon and cellulose.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Degradable Biotinylated Polyesters for Cancer Cell-Selective Targeting and Anticancer Drug Delivery. 肿瘤细胞选择性靶向和抗癌药物递送的可降解生物素化聚酯。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-13 DOI: 10.1021/acs.biomac.5c00725
Subhendu Biswas, Priya Rajdev, Ankita Banerjee, Anindita Das
{"title":"Degradable Biotinylated Polyesters for Cancer Cell-Selective Targeting and Anticancer Drug Delivery.","authors":"Subhendu Biswas, Priya Rajdev, Ankita Banerjee, Anindita Das","doi":"10.1021/acs.biomac.5c00725","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00725","url":null,"abstract":"<p><p>The growing demand for biodegradable polymers capable of stimuli-responsive drug release is challenged by limitations in facile synthetic methods. In this study, two biotin-functionalized amphiphilic polyesters (<b>P1</b> and <b>P2</b>) were synthesized through step-growth polymerization, aiming to achieve biotin receptor-mediated cancer cell selective uptake. In addition to polar biotin, <b>P2</b> incorporates a hydrophobic fluorescent dye, which enabled intracellular fluorescence tracking. <b>P2</b> self-assembled into highly biocompatible spherical nanoaggregates (∼120 nm) in water, which showed effective encapsulation of the hydrophobic anticancer drug doxorubicin (DOX). It displayed ∼85-90% internalization in biotin-overexpressed cancer cells (HeLa and MCF7) contrary to only ∼5-10% uptake in noncancerous cells (NIH 3T3), as determined by flow cytometry and fluorescence microscopy. Cell-selective DOX release was likely induced by the polyester degradation in the acidic cancer microenvironment and via endogenous esterases, evident from size exclusion chromatography (SEC) and dynamic light scattering (DLS) experiments. These findings highlight the potential of stimuli-responsive degradable polyester nanocarriers for targeted cancer treatment.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lignin-Grafted Poly(n-Butyl Acrylate) Copolymers as Soft Materials for Adhesive Applications: A Comparison of Hardwood, Softwood, and Straw Lignin. 木质素接枝的聚丙烯酸正丁酯共聚物作为胶粘剂的软质材料:硬木、软木和秸秆木质素的比较。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-12 DOI: 10.1021/acs.biomac.5c00061
Rupali Bhadane, Oskar Backman, Peter Uppstu, Jan-Henrik Smått, Chunlin Xu, Patrik C Eklund
{"title":"Lignin-Grafted Poly(<i>n</i>-Butyl Acrylate) Copolymers as Soft Materials for Adhesive Applications: A Comparison of Hardwood, Softwood, and Straw Lignin.","authors":"Rupali Bhadane, Oskar Backman, Peter Uppstu, Jan-Henrik Smått, Chunlin Xu, Patrik C Eklund","doi":"10.1021/acs.biomac.5c00061","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00061","url":null,"abstract":"<p><p>Lignin from birch (BLN), spruce (SLN), and wheat straw (WSLN) was first converted into bromoisobutyrate-based macroinitiators (LNBr) and subsequently grafted with <i>n</i>-butyl acrylate (LNBA) copolymers via atom transfer radical polymerization (ATRP). The influence of hardwood, softwood, and straw lignin on the properties of the copolymers was investigated in terms of thermal behavior, rheology, and tack test. Structural analysis by FTIR, NMR, and SEC/GPC confirmed successful grafting and an increased and broad molecular weight distribution. Thermal analysis (DSC and TGA) showed increased glass transition temperatures (<i>T</i><sub>g</sub>) and different thermal degradation compared to the homopolymer poly(<i>n</i>-butyl acrylate). Additionally, BLN-based copolymers with varying degrees of polymerization (2, 4, and 10) were synthesized to optimize the material properties. The copolymers showed adhesive properties for all BLNBA and SLNBA variants, with BLNBA2 and BLNBA4 meeting the Dahlquist criteria for pressure-sensitive adhesives.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sulfonium-Based Polymers: Underestimated Moieties for Structural Modification in Versatile Bioapplications. 磺胺基聚合物:在多种生物应用中结构修饰被低估的部分。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-11 DOI: 10.1021/acs.biomac.5c00635
Ruili Wang, Zhiyuan Ma, Meifang Zhu
{"title":"Sulfonium-Based Polymers: Underestimated Moieties for Structural Modification in Versatile Bioapplications.","authors":"Ruili Wang, Zhiyuan Ma, Meifang Zhu","doi":"10.1021/acs.biomac.5c00635","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00635","url":null,"abstract":"<p><p>Polysulfoniums, sulfur-rich cationic polymers with trivalent sulfonium motifs, are promising biomaterials due to their high charge density, structural flexibility, and biocompatibility. This review highlights recent synthetic strategies: main-chain polymers via thiol-ene/epoxy click chemistry and pendant functionalization using ROMP, ROP, or RAFT polymerization, alongside postpolymerization alkylation. Their sulfonium groups selectively disrupt anionic microbial membranes, enabling broad-spectrum antibacterial action against pathogens like MRSA without inducing resistance. Stimuli-triggered dissociation enhances intracellular delivery, bolstering efficacy while reducing toxicity. These polymers also stabilize protein via sulfonium-π interactions and enable targeted therapies though zwitterionic or covalent architectures. The tunable UCST/LCST behavior and anion/pH responsiveness support smart hydrogels for wound healing and biofilm removal. Compared to ammonium and phosphonium analogs, polysulfoniums offer superior biocompatibility and membrane disruption, making them ideal for antimicrobial coatings, gene therapy, and cancer treatment. This interdisciplinary synergy between polymer science and biotechnology underscores their potential to address critical challenges in healthcare and materials science.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Codelivery of Anti-PD-L1 and Indocyanine Green by a β-Cyclodextrin-Based Nanogel Carrier System for Cancer-Targeted Photothermal and Immunotherapy. 基于β-环糊精纳米凝胶载体系统的抗pd - l1和吲哚菁绿共递送用于癌症靶向光热和免疫治疗。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-11 DOI: 10.1021/acs.biomac.5c00489
Xichuan Tang, Yuting Wen, Zhongxing Zhang, Xia Song, Jingling Zhu, Minjie Zheng, Jun Li
{"title":"Codelivery of Anti-PD-L1 and Indocyanine Green by a β-Cyclodextrin-Based Nanogel Carrier System for Cancer-Targeted Photothermal and Immunotherapy.","authors":"Xichuan Tang, Yuting Wen, Zhongxing Zhang, Xia Song, Jingling Zhu, Minjie Zheng, Jun Li","doi":"10.1021/acs.biomac.5c00489","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00489","url":null,"abstract":"<p><p>Programmed death-ligand 1 (PD-L1), an immune checkpoint protein, serves as a \"don't eat me\" signal that allows cancer cells to evade detection and clearance by the immune system. Blocking PD-L1 with the PD-L1 antibody (aPD-L1) can restore the immunity. Photothermal therapy (PTT), meanwhile, induces local tumor cell death and releases damage-associated molecular patterns (DAMPs) to further stimulate immune responses. Here, we developed a multifunctional nanogel system, composed of β-cyclodextrin (β-CD), polyethylenimine (PEI), and polyethylene glycol (PEG), referred to as CPP nanogels, designed for the codelivery of aPD-L1 and indocyanine green (ICG), a PTT photosensitizer. The β-CD moieties facilitated ICG loading through host-guest interactions, while PEI enabled aPD-L1 conjugation. Upon targeting tumor cells, the nanogels blocked PD-L1 and, under 808 nm laser irradiation, triggered PTT-induced DAMPs release. By promoting both heat-induced cell death and immune responses, the multifunctional CPP nanogels represent a promising system potentially for treating localized and metastatic cancers.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broad-Spectrum Antiviral Styrene Maleic-Acid Copolymer Lipid Particle Nanodiscs for pH-Responsive Irreversible Virus Inactivation. 广谱抗病毒苯乙烯马来酸共聚物脂质颗粒纳米片用于ph响应不可逆病毒灭活。
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-10 DOI: 10.1021/acs.biomac.5c00037
Jaehyeon Hwang, Misoo Kim, Younghun Jung, Soomin Kim, Beom Kyu Kim, Soyun Choi, Wonbeom Park, Hyunseok Oh, Jeonghui Moon, Jeong Hyeon Yoon, Suhyun Kim, Hwanju Kim, Hyunjoo Choo, EunKhang Park, Min Kyeom Kim, Seokoh Moon, Seokhyeon Yu, Sangwon Jung, Min-Suk Song, Woo-Jae Chung, Dae-Hyuk Kweon
{"title":"Broad-Spectrum Antiviral Styrene Maleic-Acid Copolymer Lipid Particle Nanodiscs for pH-Responsive Irreversible Virus Inactivation.","authors":"Jaehyeon Hwang, Misoo Kim, Younghun Jung, Soomin Kim, Beom Kyu Kim, Soyun Choi, Wonbeom Park, Hyunseok Oh, Jeonghui Moon, Jeong Hyeon Yoon, Suhyun Kim, Hwanju Kim, Hyunjoo Choo, EunKhang Park, Min Kyeom Kim, Seokoh Moon, Seokhyeon Yu, Sangwon Jung, Min-Suk Song, Woo-Jae Chung, Dae-Hyuk Kweon","doi":"10.1021/acs.biomac.5c00037","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c00037","url":null,"abstract":"<p><p>Respiratory viruses, such as influenza A virus and SARS-CoV-2, continue to pose significant global health challenges. Current antivirals, which are often specific to a single virus, face limitations due to rapid mutations and the emergence of new strains. In this study, we introduce styrene maleic acid copolymer lipid particle nanodiscs (SMALP-NDs) as a broad-spectrum antiviral platform that employs a dual mode of action. First, SMALP-NDs bind to positively charged viral proteins via their negatively charged surfaces, thereby blocking viral entry. Second, they induce the collapse of viral envelopes under acidic conditions similar to those in the endosome, leading to virus inactivation via a cell-mediated mechanism. SMALP-NDs demonstrated broad-spectrum antiviral activity against influenza A/B and multiple SARS-CoV-2 variants, including Omicron JN.1, as well as herpes simplex virus types 1 and 2 and vaccinia virus, underscoring their versatility. Intranasal administration of SMALP-NDs has successfully protected mice from lethal H1N1 and H5N2 influenza A viruses as well as SARS-CoV-2. These findings underscore that SMALP-NDs effectively counteract the increasing positive charge of emerging viral proteins through their negatively charged surfaces while leveraging pH-responsive virus inactivation mechanisms to achieve high antiviral efficacy with low toxicity, offering a significant advantage over traditional antiviral nanomaterials.</p>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144264758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-09
Mahdi Hezwani, Derecash Anokye, Douglas E. Soutar, Melissa Ligorio, Neil Prabhakar, Jack C. Oram, Alexander J. Cantor, Garrett D. Jackson, Roberto Terracciano, Marc Walker and Alexander N. Baker*, 
{"title":"","authors":"Mahdi Hezwani,&nbsp;Derecash Anokye,&nbsp;Douglas E. Soutar,&nbsp;Melissa Ligorio,&nbsp;Neil Prabhakar,&nbsp;Jack C. Oram,&nbsp;Alexander J. Cantor,&nbsp;Garrett D. Jackson,&nbsp;Roberto Terracciano,&nbsp;Marc Walker and Alexander N. Baker*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00125","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144432351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-09
Gianna Tutoni, Annette Lu, Matthew E. Bonacci, Tony Jun Huang and Matthew L. Becker*, 
{"title":"","authors":"Gianna Tutoni,&nbsp;Annette Lu,&nbsp;Matthew E. Bonacci,&nbsp;Tony Jun Huang and Matthew L. Becker*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.5c00443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144432370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IF 5.5 2区 化学
Biomacromolecules Pub Date : 2025-06-09
Jun Feng*, Polina Ponomareva, Kunpeng Liu, Chuanxiong Nie, Rui Chen and Rainer Haag*, 
{"title":"","authors":"Jun Feng*,&nbsp;Polina Ponomareva,&nbsp;Kunpeng Liu,&nbsp;Chuanxiong Nie,&nbsp;Rui Chen and Rainer Haag*,&nbsp;","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"XXX-XXX XXX-XXX"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/pdf/10.1021/acs.biomac.4c01744","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144432385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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