Biomacromolecules最新文献_第5页

A Hydrogel Implantable Supercapacitor with Tissue-Adhesive Using PEDOT:PSS as Active Material 以PEDOT:PSS为活性材料的组织胶粘剂水凝胶植入式超级电容器。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00300

Suting Zhou, Meimei Yu, Yumeng Wang, Yuxia Zhang, Xiangya Wang, Fen Ran

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引用次数: 0

Self-Assembled Keratin Nanoparticles Prepared by Partial Hydrolysis and Their Restructuring Response to pH Shifting for Biomolecule Encapsulation 部分水解制备自组装角蛋白纳米颗粒及其对pH变化的重组响应。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.4c01773

Xiaojie Qin , Yi Zhang , Changyan Zhang , Yujie Guo , Johannes H. Bitter , Chunhui Zhang , Elinor L. Scott

{"title":"Self-Assembled Keratin Nanoparticles Prepared by Partial Hydrolysis and Their Restructuring Response to pH Shifting for Biomolecule Encapsulation","authors":"Xiaojie Qin , Yi Zhang , Changyan Zhang , Yujie Guo , Johannes H. Bitter , Chunhui Zhang , Elinor L. Scott","doi":"10.1021/acs.biomac.4c01773","DOIUrl":"10.1021/acs.biomac.4c01773","url":null,"abstract":"<div><div>Keratin, an abundant biopolymer in animal byproducts, holds promise as a biomolecule delivery carrier due to its biocompatibility, biodegradability, and low toxicity. However, its intrinsic stability from disulfide bonds limits broader application. Here, we present a strategy to convert waste feather keratin into keratin nanoparticles (KNPs) via partial hydrolysis and pH shifting. At 5% degree of hydrolysis (DH), keratin self-assembled into spherical KNPs with reduced size (∼123 nm) and enhanced solubility (94.5%). These KNPs displayed pH-triggered structural transitions (open state at pH 2.0 → closed at pH 7.0) and high loading efficiency (>93%) for insulin and resveratrol, offering partial protection against gastrointestinal enzymatic degradation and low cytotoxicity. In contrast, higher DH (≥10%) increased β-sheet content and hydrophobic exposure, promoting KNP aggregation and lowering their pH responsiveness and biomolecule encapsulation. Our findings demonstrate the potential of 5% DH KNPs as nanocarriers, providing a sustainable approach for nutrient and pharmaceutical applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (177KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4027-4039"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G‑Quadruplexes 分子拥挤对形成多个g -四联体的端粒悬垂可及性的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00360

Golam Mustafa, Sajad Shiekh, Janan Alfehaid, Sineth G. Kodikara, Hamza Balci

{"title":"Impact of Molecular Crowding on Accessibility of Telomeric Overhangs Forming Multiple G‑Quadruplexes","authors":"Golam Mustafa, Sajad Shiekh, Janan Alfehaid, Sineth G. Kodikara, Hamza Balci","doi":"10.1021/acs.biomac.5c00360","DOIUrl":"10.1021/acs.biomac.5c00360","url":null,"abstract":"<div><div>Molecular crowdinga defining feature of the cellular environmentaffects folding kinetics, conformation, and stability of G-quadruplex (GQ) structures. However, its influence on the overall architecture and accessibility of telomeric overhangs containing multiple GQs remains largely unexplored. In this study, we employed single-molecule FRET and FRET-PAINT to address this question. We examined the accessibility of telomeric overhangs, capable of forming 1–6 GQs, to a short complementary peptide nucleic acid (PNA) imager probe in the presence of 200 and 6000 Da polyethylene glycol (PEG) molecules (PEG-200 and PEG-6000). We observed a progressive compaction and architectural condensation of the overhang as PEG concentration increased. At 30% concentration, this compaction was accompanied by approximately 3-fold and 8-fold reduction in probe accessibility in PEG-200 and PEG-6000, respectively. These findings offer new insights into how the crowded cellular environment may compact telomeric overhangs and modulate their structural and functional properties.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (79KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4380-4386"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Bioadhesive Functional Peptide-Derived Supramolecular Hydrogel for the Promotion of Corneal Re-Epithelization 促进角膜再上皮形成的生物粘附功能肽衍生的超分子水凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00221

Lei Lei , Jia Liu , Yueting Shi, Yiping Wu, Wei Wu, Yuhan Hu, Haoxuan Wang, Jiaqing Wang, Xingyi Li

{"title":"A Bioadhesive Functional Peptide-Derived Supramolecular Hydrogel for the Promotion of Corneal Re-Epithelization","authors":"Lei Lei , Jia Liu , Yueting Shi, Yiping Wu, Wei Wu, Yuhan Hu, Haoxuan Wang, Jiaqing Wang, Xingyi Li","doi":"10.1021/acs.biomac.5c00221","DOIUrl":"10.1021/acs.biomac.5c00221","url":null,"abstract":"<div><div>The rapid corneal re-epithelization after injury is crucial for maintaining corneal homeostasis and barrier function. This study reports a bioadhesive functional peptide-derived supramolecular hydrogel (FBA-FFGGRGD) for promoting corneal re-epithelization. The aldehyde-modified bioactive peptide (RGD) endows the hydrogel with bioadhesive properties, enabling covalent anchoring to corneal basement membrane proteins via Schiff base reaction. Compared with its analogue (TA-FFGGRGD), FBA-FFGGRGD significantly enhances adhesion, migration, and proliferation of human corneal epithelial cells (HCECs), doubling cell numbers within 48 h and upregulating zonula occludens-1 (ZO-1) expression. <em>In vivo</em> studies show that the hydrogel exhibits excellent ocular biocompatibility, prolongs precorneal retention (∼40 min), and promotes stratified epithelium formation in a rabbit model of corneal injury. By remodeling the epithelial barrier, this bioadhesive hydrogel provides a promising strategy for corneal homeostasis preservation and ocular disorder prevention.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (193KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4219-4229"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spider Silk-Inspired Flexible Biomacromolecular Composite with Electrical and Thermal Functionality from Mesoporous Bamboo 由介孔竹子制成的具有电和热功能的蜘蛛丝启发的柔性生物大分子复合材料。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00537

Tianfang Zhang , Luxi He , Xiangyu Zhao , Wenrui Xie , Zhengbin He , Zhenyu Wang , Songlin Yi

{"title":"Spider Silk-Inspired Flexible Biomacromolecular Composite with Electrical and Thermal Functionality from Mesoporous Bamboo","authors":"Tianfang Zhang , Luxi He , Xiangyu Zhao , Wenrui Xie , Zhengbin He , Zhenyu Wang , Songlin Yi","doi":"10.1021/acs.biomac.5c00537","DOIUrl":"10.1021/acs.biomac.5c00537","url":null,"abstract":"<div><div>Inspired by the hierarchical architecture of spider silk, this study introduces a biobased macromolecular composite that combines mechanical flexibility, thermal regulation, and electrical performance. The composite is constructed using a delignified bamboo scaffold, which acts as a naturally aligned, mesoporous framework of cellulose-based macromolecules, integrated with carboxylated multiwalled carbon nanotubes and poly (vinyl alcohol). This design yields a mechanically resilient macromolecular network with stable electrical conductivity under cyclic deformation. The composite achieves enhanced thermal conductivity and demonstrates a 7.29% increase in ice-melting efficiency. Importantly, under prolonged thermal exposure, the composite undergoes thermal degradation, forming a protective carbonaceous char layer that suppresses combustion and reduces CO<sub>2</sub> and particulate emissions by 37.2 and 84.6%, respectively. The intrinsic mesoporous structure of bamboo provides an ultralight yet robust template, maintaining mechanical integrity even under cyclic stress. Additionally, the conductive nanomaterials improve interfacial properties, making this composite a promising candidate for durable, biobased flexible electronics and thermally stable structural applications. These multifunctional characteristics highlight the potential of natural macromolecular architectures in developing sustainable, biodegradable, and high-performance polymeric systems for flexible electronics and thermally stable applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (179KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4544-4557"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14

Ayan Dutta, and , William M. Gramlich*,