Biomacromolecules最新文献_第5页

Retraction of "Solubilization of Docetaxel in Poly(ethylene oxide)-block-poly(butylene/styrene oxide) Micelles". “多西紫杉醇在聚（环氧乙烷）-块聚（丁烯/环氧苯乙烯）胶束中的增溶作用”的撤回。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-09 DOI: 10.1021/acs.biomac.4c01583

Mahmoud Elsabahy, Marie-Ève Perron, Nicolas Bertrand, Ga-Er Yu, Jean-Christophe Leroux

引用次数: 0

Discrimination between Purine and Pyrimidine-Rich RNA in Liquid-Liquid Phase-Separated Condensates with Cationic Peptides and the Effect of Artificial Crowding Agents. 阳离子多肽液-液相分离凝聚物中富含嘌呤和嘧啶的RNA的鉴别及人工拥挤剂的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-11 DOI: 10.1021/acs.biomac.4c01282

Anika L Moller, Isis A Middleton, Grace E Maynard, Lachlan B Cox, Anna Wang, Hsiu L Li, Pall Thordarson

{"title":"Discrimination between Purine and Pyrimidine-Rich RNA in Liquid-Liquid Phase-Separated Condensates with Cationic Peptides and the Effect of Artificial Crowding Agents.","authors":"Anika L Moller, Isis A Middleton, Grace E Maynard, Lachlan B Cox, Anna Wang, Hsiu L Li, Pall Thordarson","doi":"10.1021/acs.biomac.4c01282","DOIUrl":"10.1021/acs.biomac.4c01282","url":null,"abstract":"Membraneless organelles, often referred to as condensates or coacervates, are liquid-liquid phase-separated systems formed between noncoding RNAs and intrinsically disordered proteins. While the importance of different amino acid residues in short peptide-based condensates has been investigated, the role of the individual nucleobases or the type of heterocyclic structures, the purine vs pyrimidine nucleobases, is less researched. The cell's crowded environment has been mimicked in vitro to demonstrate its ability to induce the formation of condensates, but more research in this area is required, especially with respect to RNA-facilitated phase separation and the properties of the crowding agent, poly(ethylene glycol) (PEG). Herein, we have shown that the nucleotide base sequence of RNA can greatly influence its propensity to undergo phase separation with cationic peptides, with the purine-only RNA decamer (AG)5 readily doing so while the pyrimidine-only (CU)5 does not. Furthermore, we show that the presence and size of a PEG macromolecular crowder affects both the ability to phase separate and the stability of coacervates formed, possibly due to co-condensation of PEG with the RNA and peptides. This work sheds light on the presence of low-complexity long purine- or pyrimidine-rich noncomplementary repeat (AG or CU) sequences in various noncoding RNAs found in biology.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"470-479"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics. 用于提高印刷电子中纳米纤维素薄膜基板耐水性的纤维素纳米虫涂层。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-13 DOI: 10.1021/acs.biomac.4c01463

Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen

{"title":"Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics.","authors":"Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen","doi":"10.1021/acs.biomac.4c01463","DOIUrl":"10.1021/acs.biomac.4c01463","url":null,"abstract":"Cellulose-nanomaterial-derived films are promising platforms for engineering advanced substrates for printed electronics. However, they are highly susceptible to water and humidity, which limit their wide application. To overcome these drawbacks, cellulose nanoworms (distinct hydrophobized cellulose nanomaterials) were introduced in this study as sustainable coatings to enhance the water resistance of cellulose nanofiber (CNF) films. Alcogels of nanoworms, produced via ethanol-induced swelling and ultrasonication of a cellulose pulp esterified in a deep eutectic solvent, form a dense and transparent coating on the CNF films, significantly inhibiting their water absorption and improving their surface smoothness. Furthermore, the resulting coated CNF films exhibited enhanced hydrophobicity with improved wet mechanical properties and lower water vapor permeability. In addition, the results of the ink-printing tests revealed that the coated films partially or completely inhibited ink removal. Thus, this study demonstrated that cellulose nanoworm coatings provide a promising approach to overcome the moisture sensitivity of CNF films.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"644-653"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Polymers via Cancer Cell Metabolism-Mediated Controlled Radical Polymerization and Application in Engineering of Cell Surface. 肿瘤细胞代谢介导的可控自由基聚合合成聚合物及其在细胞表面工程中的应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-17 DOI: 10.1021/acs.biomac.4c01020

Xianfeng Chu, Xiaowen Dou, Jiaying Yu, Junpeng Zhou, Di Ma, Miao Miao, Shaojun Hu, Kai Sun, Shihong Zhu, Qi Liu, Xiuming Zhang, Yong Jiang, Zhi-Fei Wang

引用次数: 0

Molecular Dynamics Study of the Structure and Mechanical Properties of Spider Silk Proteins. 蜘蛛丝蛋白结构与力学性能的分子动力学研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c01398

Zhaoting Yuan, Bohuan Fang, Qixin He, Hao Wei, Haiming Jian, Lujia Zhang

引用次数: 0

Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification. 细胞内递送：脂肪族聚碳酸酯与悬垂的巯基反应性硫代磺酸盐用于可逆聚合后改性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-04 DOI: 10.1021/acs.biomac.4c01207

Patric Komforth, Jan Imschweiler, Milena Hesse, Alina G Heck, Alexander Fuchs, Adrian V Hauck, Lutz Nuhn

{"title":"Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification.","authors":"Patric Komforth, Jan Imschweiler, Milena Hesse, Alina G Heck, Alexander Fuchs, Adrian V Hauck, Lutz Nuhn","doi":"10.1021/acs.biomac.4c01207","DOIUrl":"10.1021/acs.biomac.4c01207","url":null,"abstract":"Postpolymerization modifications are valuable techniques for creating functional polymers that are challenging to synthesize directly. This study presents aliphatic polycarbonates with pendant thiol-reactive groups for disulfide formation with mercaptans. The reductive responsive nature of this reaction allows for reversible postpolymerization modifications on biodegradable scaffolds. Six-membered cyclic carbonate monomers with pendant thiosulfonate groups were synthesized and polymerized using controlled organocatalytic ring-opening polymerization, yielding polymers with narrow molecular weight dispersities (Đ = 1.2) and intact reactive thiosulfonate side chains. Reversible modification with benzyl mercaptans achieved high degrees of disulfide modification. Additionally, thiol-reactive carbonate monomers were block-copolymerized onto polyethylene glycol (mPEG113) and then converted into benzyl disulfides, while the block copolymers' hydroxyl end groups remained available for fluorescent dye labeling. The amphiphilic block copolymers self-assembled in water into micelles (∼33 nm diameter), capable of encapsulating hydrophobic molecules. These micelles successfully delivered hydrophobic dyes into macrophages, indicating the potential for intracellular drug delivery.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"387-404"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Condensate Growth: Examining the Impact of Solute Crowder on Size Expansion. 生物凝析物生长：检查溶质聚集剂对尺寸膨胀的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-10 DOI: 10.1021/acs.biomac.4c01152

Shangqiang Xie, Congran Yue, Sheng Ye, Zhenlu Li

引用次数: 0

Recombinant Fusion Proteins with Embedded Sensing Functions as Versatile Tools for Protocell Development. 具有嵌入式传感功能的重组融合蛋白作为原始细胞发育的通用工具。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-02 DOI: 10.1021/acs.biomac.4c01095

Bornita Deb, Adriana LaVopa, Emma McDougal, Jackson Powers, Carl Denard, Yeongseon Jang

引用次数: 0

Lemon Juice-Infused PVA Nanofibers for the Development of Sustainable Antioxidant and Antibacterial Electrospun Hydrogel Biomaterials. 柠檬汁注入聚乙烯醇纳米纤维用于可持续抗氧化和抗菌电纺水凝胶生物材料的开发。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-01 DOI: 10.1021/acs.biomac.4c01466

Anna Zakrzewska, Alicja Kosik-Kozioł, Seyed Shahrooz Zargarian, Michele Zanoni, Chiara Gualandi, Massimiliano Lanzi, Filippo Pierini

{"title":"Lemon Juice-Infused PVA Nanofibers for the Development of Sustainable Antioxidant and Antibacterial Electrospun Hydrogel Biomaterials.","authors":"Anna Zakrzewska, Alicja Kosik-Kozioł, Seyed Shahrooz Zargarian, Michele Zanoni, Chiara Gualandi, Massimiliano Lanzi, Filippo Pierini","doi":"10.1021/acs.biomac.4c01466","DOIUrl":"10.1021/acs.biomac.4c01466","url":null,"abstract":"Cross-linking bonds adjacent polymer chains into a three-dimensional network. Cross-linked poly(vinyl alcohol) (PVA) turns into a hydrogel, insoluble structure exhibiting outstanding sorption properties. As an electrospinnable polymer, PVA enables the creation of nanofibrous hydrogels resembling biological tissues, thus ideal for nature-inspired platforms. PVA properties are easily adjustable through additives and an appropriate cross-linking method. Drawing inspiration from environmentally safe approaches, this work developed a new \"green\" method of low-temperature PVA cross-linking. Nanofibers were electrospun from a precursor solution of PVA dissolved in fresh lemon juice, stabilized by heating at 60 °C for 7 days, and thoroughly characterized. The obtained nanoplatform demonstrated long-term stability and enhanced mechanical properties. Its biocompatibility was confirmed, and its antibacterial and health-promoting effects were attributed to lemon juice-rich in vitamin C, a potent antioxidant with anti-inflammatory properties. The developed system has future potential for use in the biomedical engineering field as a dressing accelerating wound healing.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"654-669"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient Recycling of Glucose from Cellulose in Textiles Waste by Solid Catalysts. 固体催化剂高效回收纺织废液中纤维素中的葡萄糖。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-03 DOI: 10.1021/acs.biomac.4c01382

Qiangqiang Cui, Jing Yu, Jing Li, Cheng Zeng, Fan Bu, Xiaohong Liao, Hongzhi Hu, Zihui Liang, Chao Chen, Changhai Yi

{"title":"Efficient Recycling of Glucose from Cellulose in Textiles Waste by Solid Catalysts.","authors":"Qiangqiang Cui, Jing Yu, Jing Li, Cheng Zeng, Fan Bu, Xiaohong Liao, Hongzhi Hu, Zihui Liang, Chao Chen, Changhai Yi","doi":"10.1021/acs.biomac.4c01382","DOIUrl":"10.1021/acs.biomac.4c01382","url":null,"abstract":"The efficient conversion of cellulose into glucose is critical for advancing sustainable biofuels and bioproducts. Traditional methods face significant challenges, including inefficiencies and environmental concerns, highlighting the need for innovative catalytic systems. In this study, we successfully synthesized three hydroxyl-rich carbon-based solid acid catalysts─S-catalyzer, P-catalyzer, and C-catalyze. Utilizing an aqueous hydrothermal system, the S-catalyzer, characterized by high hydroxyl content and -SO3H groups, effectively mimicked cellulase activity, breaking glycosidic bonds and achieving a glucose yield of 68% with a cellulose conversion rate of 97.2% within 120 min. The catalysts also demonstrated remarkable recyclability, maintaining over 90% conversion efficiency across multiple cycles. This stability is attributed to the robustness of hydroxyl and -SO3H groups and the recycling of glucose as a carbonation substrate in a closed-loop system. Our findings provide a novel, environmentally sustainable method for cellulose hydrolysis, offering significant potential for scalable biofuel production and broader biotechnological applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"591-600"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0