A ROS-Scavenging and Conductive Hydrogel-Based Cardiac Patch with Controlled Release of Edaravone for Myocardial Infarction Treatment Assisted by Electrical Stimulation.

The severity and complexity of cardiovascular disease, especially myocardial infarction (MI), the leading global cause of death, cannot be overlooked. MI disrupts electrical conduction, causes cardiomyocyte damage, and generates an excessive number of reactive oxygen species (ROS). Therefore, repairing myocardial electrical integrity and scavenging ROS are two key issues in MI treatment. In this work, we designed and synthesized an MPSHU@EDR hydrogel that exhibits excellent mechanical properties, electrical conductivity, ROS-scavenging activity, antioxidant activity, and biocompatibility. In vivo studies show that the MPSHU@EDR hydrogel treats MI by improving the ROS microenvironment and enhancing electrical signal transmission. In conclusion, the MPSHU@EDR hydrogel may serve as an optimal candidate to treat MI.