Biomacromolecules最新文献_第6页

Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management. 集成光热转换、自我修复、生物粘附和抗菌活性的智能分层水凝胶结构用于下一代伤口管理。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-08 DOI: 10.1021/acs.biomac.5c01030

Wei Jiang, Zhen Weng, Yue Yin, Changling Liu, Siqi Zhan, Li Sheng, Yan Fu, Hong Yu Yang

{"title":"Intelligent Hierarchical Hydrogel Architectures Integrating Photothermal Conversion, Self-Healing, Bioadhesion and Antibacterial Activity for Next-Generation Wound Management.","authors":"Wei Jiang, Zhen Weng, Yue Yin, Changling Liu, Siqi Zhan, Li Sheng, Yan Fu, Hong Yu Yang","doi":"10.1021/acs.biomac.5c01030","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01030","url":null,"abstract":"Effective wound management remains a significant challenge in healthcare, necessitating advanced materials that can address multiple limitations of wound healing simultaneously. Herein, we developed a novel mfp5-inspired and multicross-linked hydrogel (DAPEG/GAEPL@TA/Fe) incorporating dibenzaldehyde-terminated polyethylene glycol, ε-poly-l-lysine, gallic acid, tannic acid, and Fe3+ ions. Physicochemical properties of the hydrogel, antibacterial efficacy, hemostatic capabilities, and wound healing performance were extensively assessed by means of in vitro and in vivo investigations. The DAPEG/GAEPL@TA/Fe hydrogel demonstrated strong wet adhesion, excellent mechanical properties, and self-healing capabilities. Its antibacterial efficacy was enhanced by photothermal conversion under NIR irradiation, effectively inhibiting both Gram-positive and Gram-negative bacteria. The hydrogel showed remarkable hemostatic performance in mouse models and significantly accelerated wound healing in vivo, with enhanced collagen deposition and reduced inflammation. The multifunctional DAPEG/GAEPL@TA/Fe hydrogel embodies a breakthrough in wound dressing materials, offering a comprehensive solution for complex wound management challenges. Its unique combination of properties and demonstrated efficacy suggest promising potential for clinical utilization in wound management and tissue regeneration.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Zwitterionic Conductive Hydrogel Interface for Enhanced Electrocorticography Signal Fidelity via High Conductivity, Antifouling, and Brain-Matched Mechanics. 两性离子导电水凝胶界面通过高电导率、防污和脑匹配力学增强皮质电成像信号保真度。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-07 DOI: 10.1021/acs.biomac.5c01412

Ying Xiang, Xuan He, Tingting Cheng, Weihao Zhu, Ji Pang, Yijia Cao, Meng Wu, Renjun Pei, Yi Cao

{"title":"A Zwitterionic Conductive Hydrogel Interface for Enhanced Electrocorticography Signal Fidelity via High Conductivity, Antifouling, and Brain-Matched Mechanics.","authors":"Ying Xiang, Xuan He, Tingting Cheng, Weihao Zhu, Ji Pang, Yijia Cao, Meng Wu, Renjun Pei, Yi Cao","doi":"10.1021/acs.biomac.5c01412","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01412","url":null,"abstract":"Electrocorticography (ECoG) holds considerable promise for neural signal monitoring with high spatiotemporal resolution. However, conventional rigid ECoG electrodes are often hampered by poor mechanical compliance and insufficient resistance to biofouling, leading to high interfacial impedance and compromised signal quality. While integrating conductive hydrogels into ECoG interface offers a potential solution, concurrently achieving high conductivity, mechanical compatibility with brain tissue, biosafety, and robust antifouling remains a significant challenge. This study introduces SPP@NaCl, a novel zwitterionic conductive hydrogel synthesized by doping a poly(sulfobetaine methacrylate) (pSB) hydrogel matrix with poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and employing NaCl as a Lewis acid to induce phase separation, thereby promoting an interconnected PEDOT network. The resultant SPP@NaCl hydrogel exhibits a compelling combination of properties: high electrical conductivity (∼9 S·m-1), a low Young's modulus (1.74 kPa) that closely matches brain tissue, excellent conformability, and markedly reduced protein adsorption attributable to its zwitterionic structure. When integrated with commercial ECoG electrodes, the optimized SPP@NaCl-8 hydrogel dramatically lowers interfacial impedance. The resulting Au-SPP@NaCl electrodes enabled high-fidelity, real-time monitoring of cortical epileptiform discharges in a rat seizure model and demonstrated stable, long-term neural signal acquisition in anesthetized healthy rats. This work presents a new strategy for constructing ECoG interfaces that simultaneously deliver high conductivity, mechanical compliance, biosafety, and antifouling capabilities, highlighting the significant potential of these hydrogel-integrated ECoG electrodes for advanced brain-computer interface applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Density of Mono- and Trivalent High-Mannan-Derived Targeting Structures with Different Affinities Impacts Cellular Uptake of Human Serum Albumin-Derived Nanocarriers. 具有不同亲和力的单价和三价高甘露聚糖衍生靶向结构的表面密度影响人血清白蛋白衍生纳米载体的细胞摄取。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-07 DOI: 10.1021/acs.biomac.5c01510

Robert Forster, Bellinda Lantzberg, Annabelle Weldert, Laura Rosenberger, Yanira Zeyn, Danuta Kowalczyk, Seah Ling Kuan, Christian Kersten, Matthias Bros, Tanja Weil, Tanja Schirmeister, Till Opatz

{"title":"Surface Density of Mono- and Trivalent High-Mannan-Derived Targeting Structures with Different Affinities Impacts Cellular Uptake of Human Serum Albumin-Derived Nanocarriers.","authors":"Robert Forster, Bellinda Lantzberg, Annabelle Weldert, Laura Rosenberger, Yanira Zeyn, Danuta Kowalczyk, Seah Ling Kuan, Christian Kersten, Matthias Bros, Tanja Weil, Tanja Schirmeister, Till Opatz","doi":"10.1021/acs.biomac.5c01510","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01510","url":null,"abstract":"Actively targeted delivery of nanocarriers (NC) modified with targeting structures (TS) binding to cell surface receptors, specific to target cells, enables enhanced selectivity and efficacy of cellular uptake. This is influenced by the ligand density on the NC surface. Herein, the impact of type, valency, and surface density of high-mannan derived TS on the C-type lectin receptor (CLR)-mediated uptake of human serum albumin (HSA)-based NCs in immune cell populations was investigated. Monovalent and trivalent TSs were prepared via efficient synthesis protocols and investigated regarding their affinity versus isolated carbohydrate recognition domains (CRD) of CD206 and CD209 within a NanoDSF study. Conjugation to HSA resulted in low valency and saturated NCs with a well-defined mannose epitope count. An in vitro study with bone-marrow-derived dendritic cells and splenic immune cells revealed the impact of the NC surface modification on cellular uptake and cell selectivity, allowing insights into the design of TSs and NCs.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aminolyzed Polycaprolactone Nanofiber Scaffolds with Visible Light-Activated Sterilization for Tissue Engineering Applications. 氨基化聚己内酯纳米纤维支架在组织工程中的应用。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-07 DOI: 10.1021/acs.biomac.5c01352

Robert Willimetz, Pavel Kubát, Jan Svoboda, Jana Musílková, Jiří Mosinger

{"title":"Aminolyzed Polycaprolactone Nanofiber Scaffolds with Visible Light-Activated Sterilization for Tissue Engineering Applications.","authors":"Robert Willimetz, Pavel Kubát, Jan Svoboda, Jana Musílková, Jiří Mosinger","doi":"10.1021/acs.biomac.5c01352","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01352","url":null,"abstract":"New photoactive nanofiber materials based on an aminolyzed polycaprolactone membrane with demonstrated cytocompatibility were developed. Two photoactive compounds, the photosensitizer Rose Bengal and the nitric oxide photodonor 4-nitro-3-(trifluoromethyl)aniline, were covalently bonded to the nanofiber surface, with or without a glutaraldehyde linker. The surface functionalization was confirmed via X-ray photoelectron spectroscopy, UV-vis absorption, and steady-state and time-resolved luminescence spectroscopy. Upon excitation with green or blue light, these materials efficiently generate antibacterial species, including singlet oxygen, with a slight contribution of hydrogen peroxide and nitric oxide. A potent light-induced antibacterial effect was demonstrated against Escherichia coli. Furthermore, the functionalized photoactive membranes, especially those with a glutaraldehyde linker and photosterilized by light, not only excluded the material toxicity but also demonstrated improved cell adhesion and proliferation when tested with adipose tissue-derived stem cells. These materials, which offer a unique combination of light-controlled surface sterilization and high cellular compatibility, are promising for advanced tissue engineering applications.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GSH-Triggered Nitric Oxide-Releasing Polycarbonate Nanoplatform for Synergistic Gas-Sonodynamic Antitumor Therapy. gsh触发的一氧化氮释放聚碳酸酯纳米平台协同气体-声动力抗肿瘤治疗。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-06 DOI: 10.1021/acs.biomac.5c01149

Hao Liao, Yuyue Xiong, Jinghang Li, Dongdong Wang, Jinglong Yang, Dong Xie, Lesan Yan

{"title":"GSH-Triggered Nitric Oxide-Releasing Polycarbonate Nanoplatform for Synergistic Gas-Sonodynamic Antitumor Therapy.","authors":"Hao Liao, Yuyue Xiong, Jinghang Li, Dongdong Wang, Jinglong Yang, Dong Xie, Lesan Yan","doi":"10.1021/acs.biomac.5c01149","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01149","url":null,"abstract":"Sonodynamic therapy (SDT) emerges as a promising noninvasive modality for deep tumors but is hindered by the hypoxic tumor microenvironment and glutathione (GSH)-mediated reactive oxygen species (ROS) scavenging. Herein, we report a GSH-responsive nanoplatform fabricated from an mPEG-b-PMNC copolymer, enabling spatiotemporal codelivery of nitric oxide (NO) donors and the sonosensitizer chlorin e6 (Ce6) via self-assembled micelles. Upon exposure to elevated intracellular GSH, the micelles disintegrate to release NO and Ce6 selectively. The released NO attenuates hypoxia through downregulation of hypoxia-inducible factor-1α (HIF-1α) and synergizes with ultrasound-triggered Ce6-generated ROS to yield highly cytotoxic peroxynitrite (ONOO-). This integrated synergy substantially potentiates SDT outcomes, as evidenced by an IC50 of 1.935 μg/mL for mPEG-b-PMNC@Ce6 micelles under ultrasound, outperforming free Ce6 (4.808 μg/mL) and control mPEG-b-PCL@Ce6 (2.736 μg/mL). This polycarbonate-based strategy provides a novel approach for synergistic gas-sonosensitizer delivery, overcoming key limitations of conventional SDT for treating hypoxic tumors.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Pluronic-PEI Nanocarriers for RNAi Delivery in Oral Cancer: From Polymer Synthesis to Functional Screening. 优化用于口腔癌RNAi递送的Pluronic-PEI纳米载体：从聚合物合成到功能筛选。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-06 DOI: 10.1021/acs.biomac.5c01011

Cátia Domingues, Ivana Jarak, Jorge Coelho, Rui A Carvalho, Francisco Veiga, Carla Vitorino, Marília Dourado, Ana Figueiras

{"title":"Optimizing Pluronic-PEI Nanocarriers for RNAi Delivery in Oral Cancer: From Polymer Synthesis to Functional Screening.","authors":"Cátia Domingues, Ivana Jarak, Jorge Coelho, Rui A Carvalho, Francisco Veiga, Carla Vitorino, Marília Dourado, Ana Figueiras","doi":"10.1021/acs.biomac.5c01011","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01011","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) treatment is hindered by the poor delivery of RNA interference (RNAi) therapeutics such as microRNAs (miRNAs). Here, we systematically explored the synthesis and functional optimization of Pluronic-polyethylenimine (PEI) nanocarriers for efficient miRNA delivery in OSCC. Among several Pluronic variants tested, only Pluronic L121 formed stable, fully cross-linked micellar nanogels via covalent bonding with low-molecular-weight PEI (1.8 kDa), enabling robust miRNA-100 complexation at an N/P ratio of 5:1. These cross-linked nanogels (PP03) outperform counterparts derived from other Pluronics or PEI alone, demonstrating enhanced cellular uptake and potent miRNA-mediated silencing in both 2D and 3D OSCC models. PP03 exploits a pH-sensitive ester linkage that facilitates endosomal escape through PEI's proton sponge effect combined with Pluronic-mediated osmotic modulation. The nanogels' rough 3D morphology confers superior colloidal stability and mucoadhesion, supporting oromucosal delivery. Furthermore, PP03 displayed hemocompatibility with no hemolytic or hemorrhagic events observed, highlighting its versatility for intravenous administration. This work emphasized the significance of polymer chemistry and cross-linking efficiency in designing functional RNAi nanocarriers, thereby advancing miRNA-based therapeutics for oral cancer.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intracellular Delivery of Mitochondria-Targeting Cationic Polypeptides by pH-Responsive Nanoparticles to Induce Immunogenic Cell Death. 通过ph反应纳米颗粒在细胞内递送线粒体靶向阳离子多肽诱导免疫原性细胞死亡。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-06 DOI: 10.1021/acs.biomac.5c01088

Renyong Yin, Zhihui Guo, Xueli Lv, Xidong He, Ziwen Gao, Wei Shen, Xuan Yi, Peng Zhang, Chunsheng Xiao, Xuesi Chen

{"title":"Intracellular Delivery of Mitochondria-Targeting Cationic Polypeptides by pH-Responsive Nanoparticles to Induce Immunogenic Cell Death.","authors":"Renyong Yin, Zhihui Guo, Xueli Lv, Xidong He, Ziwen Gao, Wei Shen, Xuan Yi, Peng Zhang, Chunsheng Xiao, Xuesi Chen","doi":"10.1021/acs.biomac.5c01088","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01088","url":null,"abstract":"Targeted induction of mitochondrial dysfunction by cationic polypeptides represents a promising strategy for inducing immunogenic cell death (ICD). Nevertheless, cationic polypeptides face challenges in systemic application due to poor tumor selectivity and inherent toxicity caused by their positive charges. Herein, a pH-responsive nanoparticle (CA-NP) is prepared through electrostatic self-assembly of a mitochondria-targeting cationic polypeptide (MTP) and an acid-sensitive anionic polypeptide. CA-NPs effectively shield the positive charges and improve the intratumoral accumulation of MTP. Upon cellular uptake, the pH-responsive CA-NPs can dissociate within acidic endolysosomes to release MTP. Following endolysosomal escape, the liberated MTP selectively localizes to mitochondria, causing mitochondrial damage and stimulating intracellular reactive oxygen species generation, which ultimately induces ICD. Consequently, CA-NPs substantially enhance the biosafety profile of MTP while effectively suppressing tumor growth through mitochondrial disruption and systemic antitumor immune activation. Together, these findings position pH-responsive CA-NPs as a promising therapeutic platform that could improve both the precision and the safety of cationic polypeptide-based cancer immunotherapy.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145230943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combinatorial Discovery of RAFT Cationic Polymers for mRNA Delivery: Structure-Function Insights from High-Throughput Screening and Machine Learning. 用于mRNA传递的RAFT阳离子聚合物的组合发现：来自高通量筛选和机器学习的结构-功能见解。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-06 DOI: 10.1021/acs.biomac.5c01236

Wenting Yang, Shangqian Li, Siqi Yu, Alex G C de Sá, Tanmayee Sai Sivani Ita, Tian Liang, Helen Forgham, Ruirui Qiao, Jiulong Li, Patrick S Stayton, David B Ascher, Huan Meng, Andrew K Whittaker, Changkui Fu

{"title":"Combinatorial Discovery of RAFT Cationic Polymers for mRNA Delivery: Structure-Function Insights from High-Throughput Screening and Machine Learning.","authors":"Wenting Yang, Shangqian Li, Siqi Yu, Alex G C de Sá, Tanmayee Sai Sivani Ita, Tian Liang, Helen Forgham, Ruirui Qiao, Jiulong Li, Patrick S Stayton, David B Ascher, Huan Meng, Andrew K Whittaker, Changkui Fu","doi":"10.1021/acs.biomac.5c01236","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01236","url":null,"abstract":"Cationic polymers are considered promising delivery systems for mRNA, offering potential advantages over lipid nanoparticles. Here a library of tertiary amine-containing, methacrylate-based cationic polymers with diverse molecular characteristics and properties were prepared by combinatorial RAFT polymerization for mRNA delivery. The ability of the synthesized cationic polymers to complex with mRNA was thoroughly investigated. The biological responses, including cellular uptake, cytotoxicity, and mRNA transfection efficiency, of the formed mRNA-polymer polyplexes were systemically investigated. Through high-throughput screening assays, we identified several lead polymers that showed superior effectiveness in delivering mRNA, with performance significantly outperforming other synthesized cationic polymers as well as polyethylenimine (PEI) and Lipofectamine, two benchmark gene delivery materials. To unravel the complex structure-function relationships between the chemical and physical properties of cationic polymers/mRNA polyplexes and their biological responses, machine learning analyses were conducted. These in silico studies identified several key attributes that are predictive of cellular uptake, cytotoxicity, and mRNA transfection efficiency, providing valuable insights for the future design of more potent cationic polymers for mRNA delivery.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145237495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

All-Bio-Based Flexible Chiral Nematic Cellulose Nanocrystal Films. 全生物基柔性手性向列型纤维素纳米晶体薄膜。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-05 DOI: 10.1021/acs.biomac.5c01121

Yongyue Peng, Yi Liang, Shunfeng Yu, Xinyue Wei, Shuyuan Chen, Xiaoting Niu, Wei Li, Guang Chu

引用次数: 0

Poly(glycerol sebacate): A Comparative Study of Various Synthesis Methods. 聚癸二酸甘油：各种合成方法的比较研究。

IF 5.4 2区化学

Biomacromolecules Pub Date : 2025-10-04 DOI: 10.1021/acs.biomac.5c01548

Silke Andrä-Żmuda, Paweł Chaber, Magdalena Martinka Maksymiak, Marta Musioł, Grażyna Adamus

{"title":"Poly(glycerol sebacate): A Comparative Study of Various Synthesis Methods.","authors":"Silke Andrä-Żmuda, Paweł Chaber, Magdalena Martinka Maksymiak, Marta Musioł, Grażyna Adamus","doi":"10.1021/acs.biomac.5c01548","DOIUrl":"https://doi.org/10.1021/acs.biomac.5c01548","url":null,"abstract":"This paper compares five synthesis methods for poly(glycerol sebacate) (PGS) prepolymers: high-temperature polycondensation, classical polycondensation under reduced pressure, enzymatic synthesis using Candida antarctica lipase B (CALB), enzymatic synthesis in the presence of acetone as a solvent, and Amberlyst-15-catalyzed polycondensation. All reactions were performed in the same laboratory to eliminate variability resulting from differences in instrumentation and experimental conditions. The obtained PGS samples were analyzed using FTIR, NMR, ESI-MS, GPC, DSC, and TGA. The enzymatic synthesis with CALB provided the best control of the reaction process, prevented gelation, and produced prepolymers with higher molecular weights and narrow dispersity. Structural analyses by NMR and ESI-MS revealed the presence of both linear and branched PGS structures. The obtained results clearly confirm that the synthesis strategy significantly influences the molecular architecture and physicochemical properties of the resulting PGS prepolymer. These findings provide a basis for further design of PGS-based materials for biomedical application.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0