Biomacromolecules最新文献_第6页

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09

Godwin K. Babanyinah, Abhi Bhadran, Himanshu Polara, Tejas Shah, Michael C. Biewer* and Mihaela C. Stefan*,

引用次数: 0

Mechanically Activated Starch Reticular Nanostructure Traps Ferulic Acid as a Structural and Functional Cargo 机械活化淀粉网状纳米结构作为结构和功能货物捕获阿魏酸。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.5c00335

Siyu Yao , Haohao Hu , Yushi Li , Qingqing Zhu , Huan Cheng , Mingming Guo , Donghong Liu , Enbo Xu

{"title":"Mechanically Activated Starch Reticular Nanostructure Traps Ferulic Acid as a Structural and Functional Cargo","authors":"Siyu Yao , Haohao Hu , Yushi Li , Qingqing Zhu , Huan Cheng , Mingming Guo , Donghong Liu , Enbo Xu","doi":"10.1021/acs.biomac.5c00335","DOIUrl":"10.1021/acs.biomac.5c00335","url":null,"abstract":"<div><div>Upon the scalable utilization of polyphenols, the design of their composites with polymers has received a great deal of attention. However, the starch polymer has a weak loading of hydrophobic polyphenols typically through noncovalent interactions without biochemical catalysts. Here, we tailor a reticular starch nanostructure from a starch nanosphere precursor (preSNS) that traps ferulic acid (FA) via esterification. The preSNS-FA network is activated by a green physical method via dynamic high-pressure microfluidization, exhibiting an exceptionally higher content of FA (∼38.0%) compared with the conventional starch group (only ∼1.5%). SEM, FTIR, XRD, 13C NMR, 1H NMR, and XPS results as well as molecular dynamics simulation comprehensively confirm the changes in architecture and hydrogen bonding modes with the formation of −COOR–. The preSNS-FA network also has an enzymatic hydrolysis resistance (up to 83.8%). Collectively, this work establishes a high-performance and catalyst-free synthetic route toward an esterified polyphenol complex network with potential applications in nutrient delivery, food packaging, and agriculture fields.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (184KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3759-3770"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying Computational Protein Design to Engineer Affibodies for Affinity-controlled Delivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor 应用计算蛋白设计来工程修饰血管内皮生长因子和血小板衍生生长因子的亲和控制递送。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.5c00097

Justin E. Svendsen , Madeleine R. Ford , Chandler L. Asnes , Simon C. Oh , Jonathan Dorogin , Karly M. Fear , Johnathan R. O’Hara-Smith , Lauren O. Chisholm , Sophia R. Phillips , Michael J. Harms , Parisa Hosseinzadeh , Marian H. Hettiaratchi

{"title":"Applying Computational Protein Design to Engineer Affibodies for Affinity-controlled Delivery of Vascular Endothelial Growth Factor and Platelet-Derived Growth Factor","authors":"Justin E. Svendsen , Madeleine R. Ford , Chandler L. Asnes , Simon C. Oh , Jonathan Dorogin , Karly M. Fear , Johnathan R. O’Hara-Smith , Lauren O. Chisholm , Sophia R. Phillips , Michael J. Harms , Parisa Hosseinzadeh , Marian H. Hettiaratchi","doi":"10.1021/acs.biomac.5c00097","DOIUrl":"10.1021/acs.biomac.5c00097","url":null,"abstract":"<div><div>Vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) play coordinated roles in angiogenesis. However, current biomaterial delivery vehicles for these proteins have a limited ability to precisely control the kinetics of protein release, preventing systematic exploration of their temporal effects. Here, we combined yeast surface display and computational protein design to engineer eight VEGF-specific and PDGF-specific protein binders called affibodies with a broad range of affinities for controlled protein release. Soluble affibodies modulated protein bioactivity as evidenced by changes in VEGF-induced endothelial cell proliferation and luminescent output of a PDGF-responsive cell line. Affibody-conjugated hydrogels enabled tunable protein release over 7 days. VEGF and PDGF released from affibody-conjugated hydrogels exhibited higher bioactivity than proteins released from hydrogels without affibodies, suggesting that these engineered affinity interactions could prolong protein bioactivity. This work underscores the power of computational protein design to enhance biomaterial functionality, creating a platform for tunable protein delivery.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (125KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3463-3480"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of Folate-Modified Carboxymethyl Chitosan-Sinomenine-Curcumin Nanopolymer for Targeted Treatment of Rheumatoid Arthritis 叶酸修饰羧甲基壳聚糖-青藤素-姜黄素纳米聚合物靶向治疗类风湿性关节炎的研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.4c01701

Jiamei Tang , Sihui Li , Yulu Wang , Minghao Yuan , Yan Wan , Xue Liang , Li Guo , Yiping Guo

{"title":"Study of Folate-Modified Carboxymethyl Chitosan-Sinomenine-Curcumin Nanopolymer for Targeted Treatment of Rheumatoid Arthritis","authors":"Jiamei Tang , Sihui Li , Yulu Wang , Minghao Yuan , Yan Wan , Xue Liang , Li Guo , Yiping Guo","doi":"10.1021/acs.biomac.4c01701","DOIUrl":"10.1021/acs.biomac.4c01701","url":null,"abstract":"<div><div>Sinomenine hydrochloride (SH) has been clinically utilized for many years to treat rheumatoid arthritis (RA) in both oral and injectable forms. However, its low bioavailability, poor targeting, high dosage requirements, and side effects, present significant challenges. This study developed folic acid-carboxymethyl chitosan-modified sinomenine-curcumin nanopolymers (named SCNP) for the targeted treatment of RA, to reduce dosage and side effects. The design of SCNP employs folic acid (FA) as a targeting moiety, facilitating specific binding to the folate receptor (FR) on the surface of macrophages and enabling internalization into activated macrophages via endocytosis, thereby achieving targeted delivery to sites of inflammation. In a rat and cell model of RA, SCNP was found to decrease reactive oxygen species (ROS) and pro-inflammatory factors while increasing the anti-inflammatory factor IL-10 through the NF-κB/NLRP3 pathway. These findings indicate that SCNP has the potential to lower drug dosage, enhance therapeutic efficacy, and minimize side effects such as diarrhea and rash, thereby highlighting its promise as an inflammation-targeting nanopolymer.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (169KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3291-3308"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143954181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Cyclic Poly(α-amino acid) Quaternary Ammonium Salt with Potent Antibacterial Activity and Low Toxicity 抗菌活性强、毒性低的环聚α-氨基酸季铵盐。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.5c00407

Guowenlie Gao , Wenlong Zhang , Yongchang Tian , Ting Hua , Pengqi Wan , Chunsheng Xiao , Xuesi Chen

{"title":"Cyclic Poly(α-amino acid) Quaternary Ammonium Salt with Potent Antibacterial Activity and Low Toxicity","authors":"Guowenlie Gao , Wenlong Zhang , Yongchang Tian , Ting Hua , Pengqi Wan , Chunsheng Xiao , Xuesi Chen","doi":"10.1021/acs.biomac.5c00407","DOIUrl":"10.1021/acs.biomac.5c00407","url":null,"abstract":"<div><div>Cationic antibacterial polymers have been extensively investigated as alternatives to antibiotics to address the challenges of antibiotic-resistant bacteria. However, their inevitable cytotoxicity significantly restricts their practical application. Cyclization strategies provide a reference for solving this dilemma. In this study, we designed and synthesized a series of cyclic cationic poly(α-amino acid) quaternary ammonium salts with potent antibacterial activity and low toxicity. Notably, the optimal polymer, <em>c</em>PCHLG<sub>10</sub>-C<sub>8</sub>, demonstrated remarkable antibacterial activity coupled with low cytotoxicity, exhibiting a selectivity index (SI = 128) against S. aureus that was 8-fold higher than the corresponding linear structure <em>l</em>PCHLG<sub>10</sub>-C<sub>8</sub> (SI = 16). Circular dichroism spectroscopy results indicated that the cyclic structure contributed to reduced cytotoxicity by diminishing the degree of α-helix conformation. Additionally, <em>c</em>PCHLG<sub>10</sub>-C<sub>8</sub> displayed rapid bactericidal properties, negligible propensity to induce bacterial resistance, and effectively inhibited or cleared bacterial biofilms. Furthermore, in a mouse epidermal wound infection model, <em>c</em>PCHLG<sub>10</sub>-C<sub>8</sub> showed outstanding in vivo antibacterial effects. Hence, this study offers a promising approach for designing cationic polymers that balance antimicrobial activity and biocompatibility.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (166KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3805-3818"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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3D Bioprinted ImmunomodulationThe Advancing Landscape of Next-Generation Immuno-oncology 生物3D打印免疫调节──新一代免疫肿瘤学的发展前景。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.4c01816

Souvik Debnath , Sachin Latiyan , Nipun Jain , Sudipto Datta , Dileep Pathote , Tithi Bhowmick , Avinaba Mukherjee

{"title":"3D Bioprinted ImmunomodulationThe Advancing Landscape of Next-Generation Immuno-oncology","authors":"Souvik Debnath , Sachin Latiyan , Nipun Jain , Sudipto Datta , Dileep Pathote , Tithi Bhowmick , Avinaba Mukherjee","doi":"10.1021/acs.biomac.4c01816","DOIUrl":"10.1021/acs.biomac.4c01816","url":null,"abstract":"<div><div>Tumor microenvironment (TME) alteration can lead to tumorigenesis, where tumors evade the immune system and spread. Thus, immunomodulation inside the TME may be a useful therapeutic approach. In this regard, bioprinting has become a potential technique for developing therapeutic solutions that offer improved control over immune modulation. Through the use of novel immune cell therapies and realistic tumor models, it provides a platform for advancing cancer immunotherapy. By examining the complex mechanisms of immunomodulation in tumorigenesis, this review article clarifies how interactions between the immune system and the tumor microenvironment affect the initiation and spread of cancer. Additionally, the effectiveness of 3D bioprinting in modulating and activating immune cells, such as T cells, dendritic cells, and macrophages, has also been analyzed. A summary of current research shows the pivotal role of 3D bioprinting in establishing a solid foundation for advancing anticancer studies and revolutionizing cancer treatment through immunotherapeutic strategies.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (56KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3255-3280"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09

Stéphane Gineste, Alexandre Wodrinski, Tiffany Campion, Pascale Laborie, Jia-Hui Lim, Stéphanie Balor, Barbara Lonetti, Christophe Mingotaud, Jean-Luc Putaux* and Anne-Françoise Mingotaud*,

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IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09

Yidan Wen, Andrea Petkovic, Juliana Vicente, John Allingham and Kevin De France*,

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IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09

Nahuel N. Foressi, Leandro Cruz Rodríguez, Natalia Wilke and M. Soledad Celej*,

引用次数: 0

Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer 聚（2-（二乙胺）甲基丙烯酸乙酯）功能化碳纳米点作为三阴性乳腺癌siRNA递送和Survivin沉默的治疗平台

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-06-09 DOI: 10.1021/acs.biomac.5c00267

Paola Varvarà , Gennara Cavallaro , Nicolò Mauro

{"title":"Poly(2-(diethylamino)ethyl methacrylate)-Functionalized Carbon Nanodots as Theranostic Platforms for siRNA Delivery and Survivin Silencing in Triple-Negative Breast Cancer","authors":"Paola Varvarà , Gennara Cavallaro , Nicolò Mauro","doi":"10.1021/acs.biomac.5c00267","DOIUrl":"10.1021/acs.biomac.5c00267","url":null,"abstract":"<div><div>This study describes the development of carbon nanodot (CDs)-based theranostic nanocarriers that integrate gene silencing with fluorescence imaging. Nitrogen- and sulfur-doped CDs were functionalized through controlled radical surface polymerization of 2-(diethylamino)ethyl methacrylate (DEAEMA), yielding self-tracking, cationic siRNA carriers CDs-pDEAEMA. The functionalization of CDs enhanced their fluorescence, broadening the emission spectrum toward the biologically transparent window. Fluorescent CDs-pDEAEMA effectively bound siRNA, remaining stable under physiological conditions, while in vitro studies proved their hemocompatibility and cytocompatibility on human dermal fibroblasts. Moreover, the ability to deliver BIRC5 siRNA was demonstrated in MDA-MB-231, successfully transfecting triple-negative breast cancer cells and resulting in an 80% reduction in the anti-apoptotic protein survivin. Furthermore, uptake studies demonstrated that the theranostic CDs are efficiently internalized in tumor cells and are clearly detectable by fluorescence imaging in the red region. These findings highlight the potential of CDs-pDEAEMA as an advanced theranostic tool for real-time tracking of siRNA therapy of breast cancer.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (156KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 6","pages":"Pages 3666-3679"},"PeriodicalIF":5.5,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143951539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0