Biomacromolecules最新文献_第6页

Application of an Injectable Thermosensitive Hydrogel Drug Delivery System for Degenerated Intervertebral Disc Regeneration. 可注射热敏水凝胶给药系统在退变椎间盘再生中的应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-13 DOI: 10.1021/acs.biomac.4c00965

Yuheng Liu, Chuan Guo, Yu Wang, Qing-Quan Kong

引用次数: 0

Impact of Acetylation, Succinylation, and pH on DNA Packaging in PEI-Based Polyplexes. 乙酰化、琥珀酰化和pH对pei基多聚物中DNA包装的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-17 DOI: 10.1021/acs.biomac.4c00648

Md Nasir Uddin, Md Abu Monsur Dinar, Leah E Schrass, Daniel W Pack, Jason E DeRouchey

引用次数: 0

Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity. 具有增强生物活性的柔韧而坚固的壳聚糖压电薄膜

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 DOI: 10.1021/acs.biomac.4c01464

Srishti Chakraborty, Souvik Debnath, Kailas Mahipal Malappuram, Sampath Parasuram, Huan-Tsung Chang, Kaushik Chatterjee, Amit Nain

引用次数: 0

Revealing the Solution Conformation and Hydration Structure of Type I Tropocollagen Using X-ray Scattering and Molecular Dynamics Simulation. 利用x射线散射和分子动力学模拟揭示I型胶原的溶液构象和水合结构。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c01261

Ying-Jen Shiu, Bradley W Mansel, Kuei-Fen Liao, Ting-Wei Hsu, Je-Wei Chang, Orion Shih, Yi-Qi Yeh, Johannes Allwang, U-Ser Jeng

{"title":"Revealing the Solution Conformation and Hydration Structure of Type I Tropocollagen Using X-ray Scattering and Molecular Dynamics Simulation.","authors":"Ying-Jen Shiu, Bradley W Mansel, Kuei-Fen Liao, Ting-Wei Hsu, Je-Wei Chang, Orion Shih, Yi-Qi Yeh, Johannes Allwang, U-Ser Jeng","doi":"10.1021/acs.biomac.4c01261","DOIUrl":"10.1021/acs.biomac.4c01261","url":null,"abstract":"Hydration plays a crucial role in regulating the dispersion behavior of biomolecules in water, particularly in how pH-sensitive hydration water network forms around proteins. This study explores the conformation and hydration structure of Type-I tropocollagen using small- and wide-angle X-ray scattering (SWAXS) and molecular dynamics (MD) simulations. The results reveal that tropocollagen exhibits a significant softening conformation in solution, transitioning from its rod-like structure in tissues to a worm-like conformation, characterized by a reduced radius of gyration of 50 nm and a persistent length of 34 nm. The SWAXS-supported MD calculations further establish a hydration water network characterized by a 2.8 Å free-water exclusion zone where water molecules are largely hydrogen-bonded to the densely distributed polar groups on the tropocollagen surfaces. These first-layer water molecules are bridged by outer water molecules extending up to 4 Å from the protein surfaces, forming a major hydration shell that encapsulates the protein.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"449-458"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11734691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular Dynamics Study of the Structure and Mechanical Properties of Spider Silk Proteins. 蜘蛛丝蛋白结构与力学性能的分子动力学研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c01398

Zhaoting Yuan, Bohuan Fang, Qixin He, Hao Wei, Haiming Jian, Lujia Zhang

引用次数: 0

Retraction of "Solubilization of Docetaxel in Poly(ethylene oxide)-block-poly(butylene/styrene oxide) Micelles". “多西紫杉醇在聚（环氧乙烷）-块聚（丁烯/环氧苯乙烯）胶束中的增溶作用”的撤回。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-09 DOI: 10.1021/acs.biomac.4c01583

Mahmoud Elsabahy, Marie-Ève Perron, Nicolas Bertrand, Ga-Er Yu, Jean-Christophe Leroux

引用次数: 0

Discrimination between Purine and Pyrimidine-Rich RNA in Liquid-Liquid Phase-Separated Condensates with Cationic Peptides and the Effect of Artificial Crowding Agents. 阳离子多肽液-液相分离凝聚物中富含嘌呤和嘧啶的RNA的鉴别及人工拥挤剂的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-11 DOI: 10.1021/acs.biomac.4c01282

Anika L Moller, Isis A Middleton, Grace E Maynard, Lachlan B Cox, Anna Wang, Hsiu L Li, Pall Thordarson

{"title":"Discrimination between Purine and Pyrimidine-Rich RNA in Liquid-Liquid Phase-Separated Condensates with Cationic Peptides and the Effect of Artificial Crowding Agents.","authors":"Anika L Moller, Isis A Middleton, Grace E Maynard, Lachlan B Cox, Anna Wang, Hsiu L Li, Pall Thordarson","doi":"10.1021/acs.biomac.4c01282","DOIUrl":"10.1021/acs.biomac.4c01282","url":null,"abstract":"Membraneless organelles, often referred to as condensates or coacervates, are liquid-liquid phase-separated systems formed between noncoding RNAs and intrinsically disordered proteins. While the importance of different amino acid residues in short peptide-based condensates has been investigated, the role of the individual nucleobases or the type of heterocyclic structures, the purine vs pyrimidine nucleobases, is less researched. The cell's crowded environment has been mimicked in vitro to demonstrate its ability to induce the formation of condensates, but more research in this area is required, especially with respect to RNA-facilitated phase separation and the properties of the crowding agent, poly(ethylene glycol) (PEG). Herein, we have shown that the nucleotide base sequence of RNA can greatly influence its propensity to undergo phase separation with cationic peptides, with the purine-only RNA decamer (AG)5 readily doing so while the pyrimidine-only (CU)5 does not. Furthermore, we show that the presence and size of a PEG macromolecular crowder affects both the ability to phase separate and the stability of coacervates formed, possibly due to co-condensation of PEG with the RNA and peptides. This work sheds light on the presence of low-complexity long purine- or pyrimidine-rich noncomplementary repeat (AG or CU) sequences in various noncoding RNAs found in biology.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"470-479"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142811429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics. 用于提高印刷电子中纳米纤维素薄膜基板耐水性的纤维素纳米虫涂层。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-13 DOI: 10.1021/acs.biomac.4c01463

Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen

{"title":"Cellulose Nanoworm Coatings for Enhancing the Water Resistance of Nanocellulose Film Substrates in Printed Electronics.","authors":"Matias Lakovaara, Juho Antti Sirviö, Rafal Sliz, Shubo Wang, Henrikki Liimatainen","doi":"10.1021/acs.biomac.4c01463","DOIUrl":"10.1021/acs.biomac.4c01463","url":null,"abstract":"Cellulose-nanomaterial-derived films are promising platforms for engineering advanced substrates for printed electronics. However, they are highly susceptible to water and humidity, which limit their wide application. To overcome these drawbacks, cellulose nanoworms (distinct hydrophobized cellulose nanomaterials) were introduced in this study as sustainable coatings to enhance the water resistance of cellulose nanofiber (CNF) films. Alcogels of nanoworms, produced via ethanol-induced swelling and ultrasonication of a cellulose pulp esterified in a deep eutectic solvent, form a dense and transparent coating on the CNF films, significantly inhibiting their water absorption and improving their surface smoothness. Furthermore, the resulting coated CNF films exhibited enhanced hydrophobicity with improved wet mechanical properties and lower water vapor permeability. In addition, the results of the ink-printing tests revealed that the coated films partially or completely inhibited ink removal. Thus, this study demonstrated that cellulose nanoworm coatings provide a promising approach to overcome the moisture sensitivity of CNF films.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"644-653"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Polymers via Cancer Cell Metabolism-Mediated Controlled Radical Polymerization and Application in Engineering of Cell Surface. 肿瘤细胞代谢介导的可控自由基聚合合成聚合物及其在细胞表面工程中的应用。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-17 DOI: 10.1021/acs.biomac.4c01020

Xianfeng Chu, Xiaowen Dou, Jiaying Yu, Junpeng Zhou, Di Ma, Miao Miao, Shaojun Hu, Kai Sun, Shihong Zhu, Qi Liu, Xiuming Zhang, Yong Jiang, Zhi-Fei Wang

引用次数: 0

Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification. 细胞内递送：脂肪族聚碳酸酯与悬垂的巯基反应性硫代磺酸盐用于可逆聚合后改性。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-04 DOI: 10.1021/acs.biomac.4c01207

Patric Komforth, Jan Imschweiler, Milena Hesse, Alina G Heck, Alexander Fuchs, Adrian V Hauck, Lutz Nuhn

{"title":"Toward Intracellular Delivery: Aliphatic Polycarbonates with Pendant Thiol-Reactive Thiosulfonates for Reversible Postpolymerization Modification.","authors":"Patric Komforth, Jan Imschweiler, Milena Hesse, Alina G Heck, Alexander Fuchs, Adrian V Hauck, Lutz Nuhn","doi":"10.1021/acs.biomac.4c01207","DOIUrl":"10.1021/acs.biomac.4c01207","url":null,"abstract":"Postpolymerization modifications are valuable techniques for creating functional polymers that are challenging to synthesize directly. This study presents aliphatic polycarbonates with pendant thiol-reactive groups for disulfide formation with mercaptans. The reductive responsive nature of this reaction allows for reversible postpolymerization modifications on biodegradable scaffolds. Six-membered cyclic carbonate monomers with pendant thiosulfonate groups were synthesized and polymerized using controlled organocatalytic ring-opening polymerization, yielding polymers with narrow molecular weight dispersities (Đ = 1.2) and intact reactive thiosulfonate side chains. Reversible modification with benzyl mercaptans achieved high degrees of disulfide modification. Additionally, thiol-reactive carbonate monomers were block-copolymerized onto polyethylene glycol (mPEG113) and then converted into benzyl disulfides, while the block copolymers' hydroxyl end groups remained available for fluorescent dye labeling. The amphiphilic block copolymers self-assembled in water into micelles (∼33 nm diameter), capable of encapsulating hydrophobic molecules. These micelles successfully delivered hydrophobic dyes into macrophages, indicating the potential for intracellular drug delivery.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"387-404"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0