Biomacromolecules最新文献_第6页

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14

Dongxuan Liu, Shanming Zhang, Fen Zheng, Yitong Chen and Long Xu*,

引用次数: 0

Biodegradation and Metabolism of Vinyl-Backbone Polymers. 乙烯基骨架聚合物的生物降解和代谢。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00584

So Jung Choi, Hokyung Lee, Ho Min Park, Sunyoung Kang, Hyoyong Kim, Byeong-Woo Kang, Beom Soo Son, So Hyun Kim, Do Yup Lee, Yan Lee

引用次数: 0

Development of Diselenide-Containing Poly(β-amino ester)s for Potent mRNA Delivery to the Spleen 含有二硒烯的聚（β-氨基酯）s的研制可有效地将mRNA传递到脾脏。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00534

Pingge Jiang , Yaxuan Wang , Qiong Wu , Ziyue Wang , Chengfan Wu , Qi Shuai , Yunfeng Yan

{"title":"Development of Diselenide-Containing Poly(β-amino ester)s for Potent mRNA Delivery to the Spleen","authors":"Pingge Jiang , Yaxuan Wang , Qiong Wu , Ziyue Wang , Chengfan Wu , Qi Shuai , Yunfeng Yan","doi":"10.1021/acs.biomac.5c00534","DOIUrl":"10.1021/acs.biomac.5c00534","url":null,"abstract":"<div><div>Polymer-based nanocarriers hold promise for nucleic acid delivery, yet the clinical translation of mRNA polymeric carriers remains hindered by insufficient delivery efficiency and cytotoxicity. Here, we synthesized 180 diselenide-containing poly(β-amino ester)s (PBAEs) via Michael addition. In vitro screening identified PBAEs with superior mRNA delivery efficiency, showing that hydrophobic amine backbones with ionizable cationic amine end-capping are critical. The effective mRNA-PBAE polyplex nanoparticles (PNPs) exhibited moderate positive charge, suitable size, potent cellular uptake, and endosomal escape. Compared with analogs lacking diselenide bonds, diselenide-containing PBAEs demonstrated robust redox responsiveness and formed PNPs with similar mRNA binding and size, but reduced internal hydrophobicity and improved cellular uptake, mediating potent mRNA delivery. Tail vein injection of diselenide-containing PNPs achieved robust splenic-targeted delivery in mice without helper lipids, unlike the lung-targeted delivery of conventional PBAEs. These findings highlight a novel diselenide-containing PBAE platform for effective mRNA delivery, which has great potential in mRNA-based immunotherapeutic applications.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (72KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4515-4528"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144214330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flexible Hydrogel Sensors for Real-Time and Synchronized Monitoring of Underwater Multiple Parameters Based on Piezoelectric Elastomer/Sodium Alginate/Carbon Quantum Dots Composites 基于压电弹性体/海藻酸钠/碳量子点复合材料的水下多参数实时同步监测柔性水凝胶传感器。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00241

Bingqing Lin , Pengfei Yang , Wei Liu , Zhiqiang Li , Zhao Wang , Yong Xiang , Qian Zhang , Xiaoran Hu

{"title":"Flexible Hydrogel Sensors for Real-Time and Synchronized Monitoring of Underwater Multiple Parameters Based on Piezoelectric Elastomer/Sodium Alginate/Carbon Quantum Dots Composites","authors":"Bingqing Lin , Pengfei Yang , Wei Liu , Zhiqiang Li , Zhao Wang , Yong Xiang , Qian Zhang , Xiaoran Hu","doi":"10.1021/acs.biomac.5c00241","DOIUrl":"10.1021/acs.biomac.5c00241","url":null,"abstract":"<div><div>Water quality monitoring refers to multiple parameters, including flow rate, pH, and temperature. However, current individual underwater sensors have certain limitations in multiparameter measurements, and integrated sensors face dilemmas, such as large size and high power consumption. In the present work, a hydrogel sensor was prepared for water quality monitoring (HSWQM) based on a piezoelectric elastomer (PE). The PE is synthesized with a long flexible backbone and cross-linking sites, providing it with a low elastic modulus and high piezoelectricity to realize stress monitoring. PE was blended with sodium alginate (SA) to make a flexible piezoelectric hydrogel (FPH), and its high swelling capacity was utilized to absorb carbon quantum dots (CQDs), thus responding to changes in pH. Further integration with a thermally sensitive alloy membrane and a Near Field Communication (NFC) module enabled real-time and synchronous monitoring of flow rate, temperature, and pH.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (87KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4230-4237"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Distribution of Substitution on Marine Biodegradability for Paramylon Acetate and Cellulose Acetate 取代分布对醋酸Paramylon和醋酸纤维素海洋生物降解性的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00252

Ruiqi Li, Jin Ho Seok, Tadahisa Iwata

{"title":"Effect of Distribution of Substitution on Marine Biodegradability for Paramylon Acetate and Cellulose Acetate","authors":"Ruiqi Li, Jin Ho Seok, Tadahisa Iwata","doi":"10.1021/acs.biomac.5c00252","DOIUrl":"10.1021/acs.biomac.5c00252","url":null,"abstract":"<div><div>Paramylon acetate and cellulose acetate with different degrees and distributions of substituents were synthesized by two different methods, de-esterification from triesters with NaOH treatment and direct esterification. Paramylon and cellulose acetate obtained by de-esterification exhibited a lower degree of substitution (DS) at C6 and a higher DS at C2 position. All of the acetate samples with different DSs were thermoformable, producing transparent films. However, melt-pressed films obtained through de-esterification exhibited greater flexibility than those prepared via direct esterification. Simultaneously, biochemical oxygen demand (BOD) tests demonstrated that paramylon and cellulose acetate obtained by de-esterification show higher biodegradability than esterification ones with the same DS. This increased biodegradability may be attributed to the lower DS of the acetyl group on C6 for paramylon and cellulose acetate obtained by de-esterification. De-esterification with NaOH treatment was validated as an effective approach for producing polysaccharide esters with excellent mechanical properties and biodegradability for both paramylon and cellulose.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (118KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4238-4247"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Macrofibers via Wet Spinning: Integrating Antibacterial, Flame-Retardant, and UV Shielding Properties Using Multinetwork Cellulose-Based Aqueous Colloids 湿纺多功能大纤维：利用多网络纤维素基水性胶体整合抗菌、阻燃和紫外线屏蔽性能。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00551

Guilu Xu , Ying Wu , Xichao Liang , Yakun Zong , Lei Pang , Lu Gan , Lin Tan

{"title":"Multifunctional Macrofibers via Wet Spinning: Integrating Antibacterial, Flame-Retardant, and UV Shielding Properties Using Multinetwork Cellulose-Based Aqueous Colloids","authors":"Guilu Xu , Ying Wu , Xichao Liang , Yakun Zong , Lei Pang , Lu Gan , Lin Tan","doi":"10.1021/acs.biomac.5c00551","DOIUrl":"10.1021/acs.biomac.5c00551","url":null,"abstract":"<div><div>Wet spinning of nanocellulose in purely aqueous systems for functionalized filament formation represents a significant yet challenging research frontier. This study develops a sustainable wet-spinning approach to produce high-performance macrofibers using TEMPO-oxidized bacterial cellulose nanofibers (TOBCN), sodium alginate (Alg), and metal-phenolic networks (MPNs). The system utilizes Fe<sup>3+</sup>-mediated cross-linking in MPNs combined with Ca<sup>2+</sup>-induced ionic bonding with TOBCN to achieve enhanced mechanical properties. The optimized Alg/TAFe<sub>1</sub>-TOBC<sub>2</sub> fiber demonstrates remarkable multifunctional characteristics, including photothermal antibacterial efficacy exceeding 99% against both Escherichia coli and Staphylococcus aureus, superior flame retardancy with 61.05% lower heat release compared to cotton, and excellent UV protection with UV protection factor values surpassing 100, which exceed standard textile requirements. The purely aqueous processing and biomass-based composition ensure environmental compatibility and biocompatibility. These macrofibers hold promise for protective textiles, combining sustainability with high performance.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (149KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4573-4583"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144339692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrogel “Affinity Trap” for microRNAs with a Self-Assembling Fluorescent “Split-Probe” to Monitor Their Expression and Degradation 用自组装荧光“分裂探针”监测microrna表达和降解的水凝胶“亲和陷阱”。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00594

Sameen Yousaf , Bahareh Amirloo , Harmesh S. Aojula , David J. Clarke , Alberto Saiani , Andrew Irwin , Elena V. Bichenkova

{"title":"Hydrogel “Affinity Trap” for microRNAs with a Self-Assembling Fluorescent “Split-Probe” to Monitor Their Expression and Degradation","authors":"Sameen Yousaf , Bahareh Amirloo , Harmesh S. Aojula , David J. Clarke , Alberto Saiani , Andrew Irwin , Elena V. Bichenkova","doi":"10.1021/acs.biomac.5c00594","DOIUrl":"10.1021/acs.biomac.5c00594","url":null,"abstract":"<div><div>The hydrogel “affinity trap” engineered here from peptides and nucleic acids into dynamic supramolecular structures offered the opportunity to measure physiological concentrations of tissue-specific microRNA expression and degradation, which are symptomatic for diseased cells and tissues. Hydrogel size-discriminating properties allowed to segregate microRNAs from complex biological media into a hydrogel matrix and entrap the target sequence via hybridization with a hydrogel-immobilized “capture” probe, where it could be detected through fluorescence quenching. We demonstrated the size-selective permeability of the hydrogel that provided a protective microenvironment for microRNAs and detection probes from cellular biological interference and afforded selective self-assembly and detection of oncogenic microRNA-21 (miR-21) in the presence of cell extracts, which is otherwise detrimental for detection in a gel-free solution. We were also able to monitor the degradation of unlabeled miR-21 by natural (RNase A and H) and synthetic (miR-21-RNase) ribonucleases and their synergistic actions, which could be potentially useful in the therapeutic knockdown of pathogenic RNAs.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (139KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4595-4611"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating Thermal Stability and Flexibility in Chitosan Films with Neutral Polyol-Boric Acid Complexes 中性多元醇-硼酸配合物对壳聚糖膜热稳定性和柔韧性的调节。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00177

Olivia E. Coer, Brandy L. Davidson, Brycelyn M. Boardman, Gretchen M. Peters

{"title":"Modulating Thermal Stability and Flexibility in Chitosan Films with Neutral Polyol-Boric Acid Complexes","authors":"Olivia E. Coer, Brandy L. Davidson, Brycelyn M. Boardman, Gretchen M. Peters","doi":"10.1021/acs.biomac.5c00177","DOIUrl":"10.1021/acs.biomac.5c00177","url":null,"abstract":"<div><div>The incorporation of boron into bioplastics offers the potential for diverse applications, with the structure–property relationship between polymer chains and boron species being the key for design. Here, we report the ability to modulate the flexibility and thermal stability of chitosan materials by varying the concentrations of erythritol and the molar equivalents of boric acid. Erythritol and boric acid form neutral complexes that alter the hydrogen-bonding face of erythritol while maintaining free diol units. 1D and 2D NMR experiments indicate preferential formation of the 1,3-isomer (85%) with minor amounts of 1,2- and 2,3-isomers. Structural, thermal, mechanical, and morphological characterization was performed using ATR-FTIR, TGA and DSC, DMA, and SEM, respectively. Molecular-level interactions of the complexes and <span>d</span>-glucosamine, the repeat unit of chitosan, showed increased aggregation and hydrogen-bonding interactions of the free diol units with the NH of <span>d</span>-glucosamine, supporting the trends in flexibility observed in the polymer system.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (147KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4174-4183"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Nitric Oxide Therapy and Phototherapy Using a Novel Bacteria Scavenger for Treatment of Acute Rhinosinusitis 一种新型细菌清除剂协同一氧化氮治疗和光疗治疗急性鼻窦炎。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14 DOI: 10.1021/acs.biomac.5c00938

Maolin Li , Hui Yan , Tong Li , Yin Liu , Haiping Zhang , Dandan Han , Songgu Wu , Junbo Gong

{"title":"Synergistic Nitric Oxide Therapy and Phototherapy Using a Novel Bacteria Scavenger for Treatment of Acute Rhinosinusitis","authors":"Maolin Li , Hui Yan , Tong Li , Yin Liu , Haiping Zhang , Dandan Han , Songgu Wu , Junbo Gong","doi":"10.1021/acs.biomac.5c00938","DOIUrl":"10.1021/acs.biomac.5c00938","url":null,"abstract":"<div><div>Acute rhinosinusitis is one of the most prevalent diseases seriously affecting the well-being and quality of life. To address this condition, a novel intelligent liposome nanoparticle (BHL@IR780@LNP) was constructed by coloading the photosensitizer IR780 and a nitric oxide donor (<span>l</span>-arginine-loaded biguanide chitosan–hyaluronic acid composite nanoparticles, BHL) onto liposome nanoparticles composed of cholesterol and soybean phospholipids. Under irradiation with an 808 nm near-infrared laser, BHL@IR780@LNP was able to generate heat and reactive oxygen species, resulting in the precise release of nitric oxide, which effectively killed 97.5% of Escherichia coli and 99.2% of Staphylococcus aureus, respectively. Furthermore, <em>in vivo</em> findings demonstrated that BHL@IR780@LNP+L could effectively eliminate 99.5% of S. aureus at the nasal mucous membrane and significantly reduce inflammatory markers. Overall, this study demonstrates a highly effective antibacterial nanoformulation (BHL@IR780@LNP+L) that innovatively integrates the synergistic effects of heat, reactive oxygen species, and nitric oxide to combat acute rhinosinusitis.</div></div><div><div><span><figure><span><img><ol><li><span><span>Download: <span>Download high-res image (145KB)</span></span></span></li><li><span><span>Download: <span>Download full-size image</span></span></span></li></ol></span></figure></span></div></div>","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":"26 7","pages":"Pages 4702-4717"},"PeriodicalIF":5.5,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144473412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-07-14

Hongli Li, Xueqin Wang, Xiaoyu Song, Hanyuan Fu, Lige Yang, Dachao Deng, Kedong Xu, Lili Li and Fei Li*,

引用次数: 0