Biomacromolecules最新文献_第7页

Robot-Assisted Synthesis of Structure-Controlled Star-Cluster Hydrogels with Targeted Mechanophysical Properties for Biomedical Applications. 机器人辅助合成具有生物医学应用目标机械物理性能的结构控制星团水凝胶。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-23 DOI: 10.1021/acs.biomac.4c01148

Vianna F Jafari, Shirin Nour, Ross A L Wylie, Daniel E Heath, Greg G Qiao

{"title":"Robot-Assisted Synthesis of Structure-Controlled Star-Cluster Hydrogels with Targeted Mechanophysical Properties for Biomedical Applications.","authors":"Vianna F Jafari, Shirin Nour, Ross A L Wylie, Daniel E Heath, Greg G Qiao","doi":"10.1021/acs.biomac.4c01148","DOIUrl":"10.1021/acs.biomac.4c01148","url":null,"abstract":"Advancements in polymer chemistry have enabled the design of macromolecular structures with tailored properties for diverse applications. Reversible addition-fragmentation chain-transfer (RAFT) polymerization is a controlled technique for precise polymer design. Automation tools further enhance polymer synthesis by enabling the rapid, reproducible preparation of polymer libraries. This study utilizes an automated platform and a biologically friendly bio-Fenton RAFT synthesis method to create hydrogels with embedded star polymers derived from complex block copolymers with controlled block lengths and sequences. Automation improves the efficiency compared to manual methods, while the choice of prepolymer and polymerization techniques ensures biocompatibility. Hydrogels formed by cross-linking linear block copolymers exhibit tunable physical, chemical, and mechanical properties. By systematically altering the prepolymer block sequences, promising hydrogel candidates for enhanced cell biocompatibility and proliferation are identified. These synthetic hydrogels mimic cellular microenvironments and offer a robust platform for biomedical applications, paving the way for an efficient hydrogel design and synthesis.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"311-322"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142880642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radical Ring-Opening Polymerization: Unlocking the Potential of Vinyl Polymers for Drug Delivery, Tissue Engineering, and More. 自由基开环聚合：释放乙烯基聚合物在药物输送、组织工程等方面的潜力。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-29 DOI: 10.1021/acs.biomac.4c01116

Mina Ghorbani, Elisabeth Prince

引用次数: 0

UV Resistance Properties of Lignin Influenced by Its Oxygen-Containing Groups Linked to Aromatic Rings. 芳香环上含氧基团对木质素抗紫外线性能的影响。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-17 DOI: 10.1021/acs.biomac.4c01246

Han Zhang, Shen Zhang, Minting Xie, Fachuang Lu, Fengxia Yue

引用次数: 0

Trends in Photopolymerization 3D Printing for Advanced Drug Delivery Applications. 用于先进药物输送应用的光聚合3D打印趋势。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-03 DOI: 10.1021/acs.biomac.4c01004

Yu Hu, Zhi Luo, Yinyin Bao

引用次数: 0

Tunable Terpolymer Series for the Systematic Investigation of Membrane Proteins. 用于膜蛋白系统研究的可调三元共聚物系列。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-26 DOI: 10.1021/acs.biomac.4c01219

Gestél C Kuyler, Elaine Barnard, Pooja Sridhar, Rebecca J Murray, Naomi L Pollock, Mark Wheatley, Timothy R Dafforn, Bert Klumperman

{"title":"Tunable Terpolymer Series for the Systematic Investigation of Membrane Proteins.","authors":"Gestél C Kuyler, Elaine Barnard, Pooja Sridhar, Rebecca J Murray, Naomi L Pollock, Mark Wheatley, Timothy R Dafforn, Bert Klumperman","doi":"10.1021/acs.biomac.4c01219","DOIUrl":"10.1021/acs.biomac.4c01219","url":null,"abstract":"Membrane proteins (MPs) are critical to cellular processes and serve as essential therapeutic targets. However, their isolation and characterization are often impeded by traditional detergent-based methods, which can compromise their native states, and retention of their native lipid environment. Amphiphilic polymers have emerged as effective alternatives, enabling the formation of nanoscale discs that preserve MPs' structural and functional integrity. We introduce a novel series of poly(styrene-co-maleic acid-co-(N-benzyl)maleimide) (BzAM) terpolymers with tunable amphiphilicity, synthesized through controlled polymerization. Designed to mimic and improve upon industry-standard poly(styrene-co-maleic acid), these well-defined terpolymers offer enhanced control over molecular weight and distribution, allowing for systematic evaluation of polymer properties and their effect on membrane solubilization. The BzAM series effectively solubilized membranes and demonstrated a direct correlation between polymer hydrophobicity and solubilization efficiency of bacterial ABC transporter, Sav1866. This research highlights the importance of rational polymer design in MP research and provides a foundation for future developments.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"415-427"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Assembled Piezoelectric Films from Aligned Lysozyme Protein Fibrils. 排列溶菌酶蛋白原纤维自组装压电薄膜。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2025-01-02 DOI: 10.1021/acs.biomac.4c01305

Donn Adam D Gito, Alireza Akbarinejad, Alexander Dixon, Thomas Loho, Michel Nieuwoudt, Qun Chen, Laura J Domigan, Jenny Malmström

{"title":"Self-Assembled Piezoelectric Films from Aligned Lysozyme Protein Fibrils.","authors":"Donn Adam D Gito, Alireza Akbarinejad, Alexander Dixon, Thomas Loho, Michel Nieuwoudt, Qun Chen, Laura J Domigan, Jenny Malmström","doi":"10.1021/acs.biomac.4c01305","DOIUrl":"10.1021/acs.biomac.4c01305","url":null,"abstract":"Piezoelectric organic polymers are promising alternatives to their inorganic counterparts due to their mechanical flexibility, making them suitable for flexible and wearable piezoelectric devices. Biological polymers such as proteins have been reported to possess piezoelectricity, while offering additional benefits, such as biocompatibility and biodegradability. However, questions remain regarding protein piezoelectricity, such as the impact of the protein secondary structure. This study examines the piezoelectric properties of lysozyme amyloid fibril films, plasticized by polyethylene glycol (PEG). The films demonstrated a measurable d33 coefficient of 1.4 ± 0.1 pCN-1, for the optimized PEG concentration, confirming piezoelectricity. The PEG was found to hydrogen-bond with the fibrils, likely impacting the piezoelectric response of the film. Polarization imaging revealed long-range alignment of the amyloid fibrils in a circumferential arrangement. These results demonstrate the potential of using amyloid fibrils, which can be formed from various proteins, to create bulk self-assembled piezoelectric materials.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"514-527"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733944/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating Cell Wall Diffusion in Wood Modified with Phenol Urea Formaldehyde Resin in Different Length Scales. 苯酚脲醛树脂改性木材在不同长度尺度上细胞壁扩散的研究。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 DOI: 10.1021/acs.biomac.4c01168

Carlo Kupfernagel, Mohammed Rahman, Rosalie Cresswell, Morwenna J Spear, Andrew Pitman, Steven P Brown, Graham A Ormondroyd

{"title":"Investigating Cell Wall Diffusion in Wood Modified with Phenol Urea Formaldehyde Resin in Different Length Scales.","authors":"Carlo Kupfernagel, Mohammed Rahman, Rosalie Cresswell, Morwenna J Spear, Andrew Pitman, Steven P Brown, Graham A Ormondroyd","doi":"10.1021/acs.biomac.4c01168","DOIUrl":"https://doi.org/10.1021/acs.biomac.4c01168","url":null,"abstract":"Wood modification using low molecular weight thermosetting resins improves the biological durability and dimensional stability of wood while avoiding increasingly regulated biocides. During the modification process, resin monomers diffuse from the cell lumen to the cell wall, occupying micropore spaces before in situ curing at 150 °C. This study investigated the mechanism of cell wall diffusion at multiple scales, comparing two test groups where diffusion was either facilitated or restricted. Antiswelling efficiency tests demonstrated improved dimensional stability when diffusion was facilitated. Differential scanning calorimetry showed that bound water was excluded more effectively from the cell wall if cell wall diffusion was enabled. Solid-state NMR spectroscopy (1H MAS and 13C MAS) with relaxation time analysis indicated that resin migrated to distinct locations within the cell wall, influenced by diffusion and drying conditions. These findings highlight how optimizing cell wall diffusion can significantly improve the performance of wood modification processes using thermosetting resins.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Wound Repair of Injectable and Self-Healing Benzaldehyde-Modified Konjac Glucomannan Oligosaccharide/Polyglutamic Acid/ε-Polylysine Hydrogel. 可注射自愈性苯甲醛修饰魔芋葡甘露聚糖/聚谷氨酸/ε-聚赖氨酸水凝胶的制备及伤口修复

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-12 DOI: 10.1021/acs.biomac.4c01407

Feng Huang, Jiajie Chen, Xuan Tang, Yujian Li, Haixin Bao, Xuan Mao, Shunqing Tang

{"title":"Preparation and Wound Repair of Injectable and Self-Healing Benzaldehyde-Modified Konjac Glucomannan Oligosaccharide/Polyglutamic Acid/ε-Polylysine Hydrogel.","authors":"Feng Huang, Jiajie Chen, Xuan Tang, Yujian Li, Haixin Bao, Xuan Mao, Shunqing Tang","doi":"10.1021/acs.biomac.4c01407","DOIUrl":"10.1021/acs.biomac.4c01407","url":null,"abstract":"Oligosaccharides always have better water solubility, higher possibilities for modification, and unique biofunctions compared with polysaccharides, but they are rarely used as the matrix of a hydrogel. Here, we prepared a composite BKOS/HPGA/PL hydrogel (BKPP hydrogel) constructed by hydrazone/imine bonds between the aldehyde groups of benzaldehyde-modified konjac glucomannan oligosaccharide (BKOS) and the primary amino groups of both hydrazide-modified polyglutamic acid (HPGA) and ε-polylysine (ε-PL). The hydrogels had both injectable and self-healing properties. The gelation time reached 23 s when 2% of BKOS (DS = 21.7%), 10% HPGA (DS = 11.5%), and 10% ε-PL solutions were mixed in a volume ratio of 5:4.5:0.5. Besides high water-retention capability and good cytocompatibility, the hydrogel also maintained both the immunoactivities of BKOS and the antibacterial performances of ε-PL and HPGA, and thus exhibited good wound healing performance in the whole cortex wound repair process of rats, which might have potential for its biomedical application.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"609-622"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142816698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors. 结合强度，而不是价，决定了亲和力靶向大分子在实体肿瘤中的积累和渗透。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-12-27 DOI: 10.1021/acs.biomac.4c01303

Anastasia K Varanko, Sonal Deshpande, Xinghai Li, Ashutosh Chilkoti

{"title":"Binding Strength, Not Valency, Dictates Accumulation and Penetration of Affinity Targeted Macromolecules into Solid Tumors.","authors":"Anastasia K Varanko, Sonal Deshpande, Xinghai Li, Ashutosh Chilkoti","doi":"10.1021/acs.biomac.4c01303","DOIUrl":"10.1021/acs.biomac.4c01303","url":null,"abstract":"The efficacy of tumor-targeted therapeutics, engineered to engage specific cellular receptors to promote accumulation and penetration, is strongly influenced by the carrier's affinity for its target and the valency of binding molecules incorporated into the carrier. Previous research has primarily focused on improving targeting by augmenting the number of binding proteins on the carrier, inadvertently raising avidity without isolating the individual effects of binding strength and valency. Herein, we precisely evaluate the impact of multivalency on tumor targeting with a recombinant approach to independently control valency, avidity, and size. Our findings reveal that constructs with equivalent binding strength exhibit comparable receptor engagement and tumor extravasation, regardless of valency. Moreover, excessive avidity adversely affected tumor accumulation and penetration, with the highest-avidity construct showing diminished exposure. These results indicate that overall binding strength, not valency, is the primary determinant of tumor targeting, providing valuable insights for designing effective macromolecular drug carriers.","PeriodicalId":30,"journal":{"name":"Biomacromolecules","volume":" ","pages":"503-513"},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142890639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to "Polysaccharide-Based pH-Responsive Nanocapsules Prepared with Bio-orthogonal Chemistry and Their Use as Responsive Delivery Systems". 对 "用生物正交化学制备的基于多糖的 pH 响应性纳米胶囊及其作为响应性递送系统的应用 "的更正。

IF 5.5 2区化学

Biomacromolecules Pub Date : 2025-01-13 Epub Date: 2024-11-27 DOI: 10.1021/acs.biomac.4c01556

Mohammad Shafee Alkanawati, Richard da Costa Marques, Volker Mailänder, Katharina Landfester, Héloïse Thérien-Aubin

引用次数: 0