Targeted Nanoactuator-Integrated Multicomponent Supramolecular Assemblies for Augmented Chemo/Chemodynamic Combination Therapies

IF 5.4 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-10-01 DOI:10.1021/acs.biomac.5c01597

Shuai Chen, , , Ning Han, , , Yuheng Ren, , , Hongxia Wang, , , Jianmei Yang, , , Junnan He, , , Mingming Chen, , , Fei Zhu, , , Jinxin Yang, , , Yan Zhao*, , and , Jin Zhang*,

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Abstract

Lung cancer remains the leading cause of cancer mortality, highlighting the need for innovative therapies. Aloe-emodin (AE), a natural anthraquinone from Aloe vera, faces clinical challenges due to tumor heterogeneity and immunosuppressive microenvironments. To address this, we combine chemodynamic therapy (CDT) with a novel supramolecular assembly (MIL-101(Fe)-Fc@AE@FACD), designed by functionalizing iron-based metal–organic frameworks (MIL-101(Fe)) with folic acid-conjugated cyclodextrin (FACD) for tumor targeting. This assembly enables dual therapeutic mechanisms: CDT-induced reactive oxygen species (ROS) generation and pH-triggered AE release. In vitro, it shows enhanced cytotoxicity against A549 cells, reducing cell viability to <15%. In vivo, it significantly inhibits tumor growth with minimal hepatorenal toxicity. This hybrid supramolecular platform enhances the antitumor efficacy of AE against lung cancer.

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靶向纳米致动器-集成多组分超分子组件用于增强化学/化学动力学联合治疗。

肺癌仍然是癌症死亡的主要原因，这突出了对创新疗法的需求。芦荟大黄素（AE）是一种天然的从芦荟中提取的蒽醌类药物，由于肿瘤的异质性和免疫抑制的微环境，在临床上面临着挑战。为了解决这个问题，我们将化学动力学治疗（CDT）与一种新的超分子组装体（MIL-101(Fe)-Fc@AE@FACD）结合起来，该超分子组装体是通过将铁基金属有机框架（MIL-101(Fe)）与叶酸共轭环糊精（FACD）功能化来设计的，用于肿瘤靶向。该组件支持双重治疗机制：cdt诱导的活性氧（ROS）产生和ph触发的AE释放。在体外，它对A549细胞显示增强的细胞毒性，降低细胞活力

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.