A ROS-Scavenging and Conductive Hydrogel-Based Cardiac Patch with Controlled Release of Edaravone for Myocardial Infarction Treatment Assisted by Electrical Stimulation.
Shiyu Wang, Xueshan Zhao, Yujia Zhan, Jiaqiao Liang, Jianyang Shi, Jun Gu, Haibo Wang
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引用次数: 0
Abstract
The severity and complexity of cardiovascular disease, especially myocardial infarction (MI), the leading global cause of death, cannot be overlooked. MI disrupts electrical conduction, causes cardiomyocyte damage, and generates an excessive number of reactive oxygen species (ROS). Therefore, repairing myocardial electrical integrity and scavenging ROS are two key issues in MI treatment. In this work, we designed and synthesized an MPSHU@EDR hydrogel that exhibits excellent mechanical properties, electrical conductivity, ROS-scavenging activity, antioxidant activity, and biocompatibility. In vivo studies show that the MPSHU@EDR hydrogel treats MI by improving the ROS microenvironment and enhancing electrical signal transmission. In conclusion, the MPSHU@EDR hydrogel may serve as an optimal candidate to treat MI.
期刊介绍：
Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine.
Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.
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