综合性期刊最新文献

{"title":"Increased and synergistic RNAi delivery using MOF polydopamine nanoparticles for biopesticide applications","authors":"Zhou Gao, Christopher Rensing, Jie Wang, Chenhui Shen, Mohammed Esmail Abdalla Elzaki, Xiaoyun Li, Jinfang Tan, Xiaoqian Jiang","doi":"10.1038/s41467-025-61604-5","DOIUrl":"https://doi.org/10.1038/s41467-025-61604-5","url":null,"abstract":"<p>RNA interference is an eco-friendly alternative to chemical pesticides, yet its efficacy in lepidopterans like <i>Spodoptera frugiperda</i> (<i>S. frugiperda</i>) is limited by poor uptake. Here, we report on ZIF-8 polydopamine nanoparticles that protect dsRNA against enzymatic degradation and active the endocytic/phagosome pathways for increased uptake. Furthermore, the uptake of nano-enabled dsRNA induces the overgrowth of <i>Serratia marcescens</i>, this reduces the <i>S. frugiperda</i> reactive oxygen species (ROS) immune response, increasing the effects of plant’s natural defenses, further inhibiting <i>Enteroccous mundtii</i> growth. This work shows the synergistic potential of nanoparticles for influencing the gut bacteria to prevent resistance mechanisms and for RNAi delivery for pest management.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"12 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Forensic skeletal and molecular anthropology face to face: Combining expertise for identification of human remains","authors":"Elena Pilli, Andrea Palamenghi, Cristina Cattaneo","doi":"10.1111/nyas.15398","DOIUrl":"https://doi.org/10.1111/nyas.15398","url":null,"abstract":"Forensic anthropology (FA) has grown significantly as a well‐established and independent discipline dedicated to the examination and identification of human remains in medicolegal and humanitarian contexts. When soft tissues are highly decomposed, skeletal analysis often provides more reliable data for reconstructing biological profiles and determining identity. The increasing number of unidentified decedents in both domestic and humanitarian scenarios highlights the need for forensic anthropologists. In this context, molecular anthropology (MA) could support FA by offering additional tools for forensic identification, although collaboration between these two fields remains uncommon. Drawing from the authors’ experience, this review emphasizes the value of collaboration to enhance case resolution. This review shows that when FA encounters limitations, MA may provide critical insight to address unanswered questions. Although the full integration of FA and MA has yet to be realized, combining the strengths of both fields allows for the creation of more comprehensive biological profiles, thus significantly improving the chances of identifying unknown remains. This interdisciplinary approach broadens FA's scope and drives the development of innovative techniques and methodologies, advancing the pursuit of truth and justice.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"697 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Genome-wide CRISPR screen in human T cells reveals regulators of FOXP3","authors":"Kelvin Y. Chen, Tatsuya Kibayashi, Ambre Giguelay, Mayu Hata, Shunsuke Nakajima, Norihisa Mikami, Yusuke Takeshima, Kenji Ichiyama, Ryusuke Omiya, Leif S. Ludwig, Kunihiro Hattori, Shimon Sakaguchi","doi":"10.1038/s41586-025-09356-6","DOIUrl":"https://doi.org/10.1038/s41586-025-09356-6","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-025-08795-5 Published online 26 March 2025</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"4 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orientation fields predict human perception of 3D shape from shading.","authors":"Celine Aubuchon,Romain Vergne,Steven A Cholewiak,Benjamin Kunsberg,Daniel Holtmann-Rice,Steven W Zucker,Roland W Fleming","doi":"10.1073/pnas.2503088122","DOIUrl":"https://doi.org/10.1073/pnas.2503088122","url":null,"abstract":"How the brain recovers the three-dimensional structure of surfaces and objects from 2D retinal images remains mysterious. Shading patterns provide one of the most powerful-yet least understood-visual depth cues. Most theories assume the brain infers surface normals from luminance values. However, this seems unlikely as visual neurons are broadly insensitive to luminance. To identify alternative cues, we measured responses of model orientation-selective cell populations to images of shaded objects. We found a surprising statistical relationship between image orientations and surface curvature properties, suggesting a way to estimate shape from shading. We find that the orientation-based cues not only predict striking illusions of shape perception when lighting varies, but also the impressive robustness of shape perception when large image modifications are introduced to directly pit luminance and image orientation cues against one another. The findings resolve the longstanding question of which image measurements drive shape from shading perception.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"11 1","pages":"e2503088122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blueprints for sustainable plant production through the utilization of crop wild relatives and their microbiomes","authors":"Muhammad Waqas, Susan R. McCouch, Davide Francioli, Susannah G. Tringe, Daniele Manzella, Colin K. Khoury, Loren H. Rieseberg, Hannes Dempewolf, Peter Langridge, Christoph-Martin Geilfus","doi":"10.1038/s41467-025-61779-x","DOIUrl":"https://doi.org/10.1038/s41467-025-61779-x","url":null,"abstract":"<p>Conserving crop wild relatives (CWR) in their natural environments, together with the complex communities of microorganisms that live with them, could lay the foundation to unlock novel mechanisms for crop resilience and new strategies for achieving food security.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"71 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structural insights into pre-pore intermediates of alpha-hemolysin in the lipidic environment","authors":"Arnab Chatterjee, Anupam Roy, Thejas Satheesh, Partho Pratim Das, Bapan Mondal, Prithiv Kishore, Mahipal Ganji, Somnath Dutta","doi":"10.1038/s41467-025-61741-x","DOIUrl":"https://doi.org/10.1038/s41467-025-61741-x","url":null,"abstract":"<p>The infectious microbe <i>Staphylococcus aureus</i> releases an array of cytotoxic pore-forming toxins (PFTs) that severely damage the cell membrane during bacterial infection. However, the interaction interfaces between the host cell membrane and toxin were hardly explored. So far, there are no pore, and intermediate structures of these toxins available in the presence of bio-membrane, which could elucidate the pore-forming mechanism. Here, we investigate the structure of different conformational states of this alpha-hemolysin (α-HL/Hla), a β-PFT in lipidic environment using single-particle cryo-EM. Additionally, we explore lipid destabilization by the toxin, using single-molecule imaging, confocal imaging, and validation of lipid-protein interactions using mutational studies. We elucidate eight cryo-EM structures of wildtype α-HL with various liposomes, which are composed of either 10:0 PC or Egg-PC/Cholesterol or Egg-PC/Sphingomyelin or 10:0 PC/Sphingomyelin. Our structural and biophysical studies confirm that different chain lengths and various membrane compositions facilitate the formation of intermediate pre-pores and complete pore species. We also demonstrate that the percentage of pre-pore population increases due to sphingomyelin-induced membrane rigidity. Altogether, this study unveils the structure-function analysis of the pre-pore to pore transition of wildtype α-HL during its crosstalk with the lipid membrane.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"93 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spin-filter tunneling detection of antiferromagnetic resonance with electrically tunable damping","authors":"Thow Min Jerald Cham, Daniel G. Chica, Xiaoxi Huang, Kenji Watanabe, Takashi Taniguchi, Xavier Roy, Yunqiu Kelly Luo, Daniel C. Ralph","doi":"10.1126/science.adq8590","DOIUrl":"https://doi.org/10.1126/science.adq8590","url":null,"abstract":"Antiferromagnetic spintronics offers the potential for higher-frequency operations and improved insensitivity to magnetic fields compared to ferromagnetic spintronics. However, previous electrical techniques to detect antiferromagnetic dynamics have utilized large, millimeter-scale bulk crystals. Here we demonstrate direct electrical detection of antiferromagnetic resonance in structures on the few-micrometer scale using spin-filter tunneling in PtTe <jats:sub>2</jats:sub> /bilayer CrSBr/graphite junctions in which the tunnel barrier is the van der Waals antiferromagnet CrSBr. This sample geometry allows not only efficient detection, but also electrical control of the antiferromagnetic resonance through spin-orbit torque from the PtTe <jats:sub>2</jats:sub> electrode. The ability to efficiently detect and control antiferromagnetic resonance enables detailed studies of the physics governing these high-frequency dynamics.","PeriodicalId":21678,"journal":{"name":"Science","volume":"9 1","pages":""},"PeriodicalIF":56.9,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single theory for the evolution of sex chromosomes and the two rules of speciation","authors":"Thomas Lenormand,&nbsp;Denis Roze","doi":"10.1126/science.ado9032","DOIUrl":"10.1126/science.ado9032","url":null,"abstract":"<div >Sex chromosomes are involved in three major empirical patterns: (i) Y (or W) chromosomes are often nonrecombining and degenerate; (ii) heterogametic offspring (XY or ZW) from interspecific crosses are more often sterile or inviable compared with homogametic offspring (Haldane’s rule); and (iii) the X (or Z) has a disproportionately large effect on reproductive isolation between species compared with autosomes (the large X effect). Each observation has received its own tailored explanation involving multiple genetic and evolutionary causes. In this work, we show that these empirical patterns all emerge from a single theory for sex chromosome evolution incorporating the coevolution of cis- and trans-acting regulators of gene expression and leading to systematic misexpression of dosage-compensated genes in heterogametic F1 hybrids, for both young and old sex chromosomes.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6756","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing carbene polarity: Unified catalytic access to donor, neutral, and acceptor carbenes","authors":"Khue N. M. Nguyen,&nbsp;Xueling Mo,&nbsp;Bethany M. DeMuynck,&nbsp;Mohamed Elsayed,&nbsp;Jacob J. A. Garwood,&nbsp;Duong T. Ngo,&nbsp;Ilias Khan Rana,&nbsp;David A. Nagib","doi":"10.1126/science.adw4177","DOIUrl":"10.1126/science.adw4177","url":null,"abstract":"<div >Metal carbenes are highly useful intermediates in organic synthesis. However, not all classes of carbene polarity are catalytically accessible, nor are there common precursors known to synthesize all of these electronically diverse carbene types. Here, we report a unified strategy to access a full range of carbenes, including those with donor substituents (EDG: OMe, NR₂, alkyl), acceptor substituents (EWG: CN, CO₂R), and electronically neutral or nonpolar substituents (H, BR₂, SiR₃, halide, aryl, heteroaryl). This Fe-catalyzed method harnesses α-Cl radicals and couples an exceptionally wide array of carbenes in (2+1) cyclopropanations and σ-bond insertions. This mild, robust, and electronically tunable synthetic method facilitated the development of a better classification system for catalytic metal carbenes (validated by both kinetic and thermodynamic quantification), as well as a carbene “click-like” reaction and aqueous adaptation for chemical biology applications.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"389 6756","pages":""},"PeriodicalIF":44.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centuries-old DNA reveals origins of Greenland’s unique dogs","authors":"","doi":"10.1038/d41586-025-02184-8","DOIUrl":"https://doi.org/10.1038/d41586-025-02184-8","url":null,"abstract":"Genomic data shed light on how populations of sled dogs — and their human handlers — have shifted over past 800 years.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"9 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144603521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}