综合性期刊最新文献

{"title":"Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis","authors":"Hongyu Chen, Ruifeng Xu, Jianhao Wang, Feng Gao, Yida Lv, Xiang Li, Fang Li, Junqin Zhao, Xi Zhang, Jiabei Wang, Ruicheng Du, Yuke Shi, Hang Yu, Shuai Ding, Wenxin Li, Jing Xiong, Jie Zheng, Liang Zhao, Xin-Ya Gao, Zhi-Hao Wang","doi":"10.1038/s41467-025-57810-w","DOIUrl":"https://doi.org/10.1038/s41467-025-57810-w","url":null,"abstract":"<p>Early life experience modulates resilience to stress in later life. Previous research implicated maternal care as a key mediator of behavioral responses to the adversity in adolescence, but details of molecular mechanisms remain elusive. Here, we show social stress activates transcription factor C/EBPβ in mPFC neurons of adolescent mice, which transcriptionally upregulates <i>Dnm1l</i> and promotes mitochondrial dysfunction, thereby conferring stress susceptibility in adolescent mice. Moreover, different maternal separation differentially regulates adolescent stress susceptibility. Mechanistically, this differential effect depends on maternal behavior-stimulated IGF-1, which inhibits neuronal C/EBPβ through mTORC1-induced C/EBPβ-LIP translation. Furthermore, we identify maternal behavior-stimulated IGF-1 is mainly released from mPFC microglia. Notably, increased maternal care under an environmental enrichment condition or maternal behavior impairment induced by repeated MPOA^Esr1+ cells inhibition in dams prevents or promotes stress susceptibility via microglial-to-neuronal IGF-1-C/EBPβ-DRP1 signaling. In this work, these findings have unveiled molecular mechanisms by which maternal behavior promotes stress resilience in adolescents.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating socio-economic and subjective well-being impacts of coal power phaseout in China","authors":"Shuaizhi Gao, Peng Zhou, Hongyan Zhang, Shuo Yang","doi":"10.1038/s41467-025-57561-8","DOIUrl":"https://doi.org/10.1038/s41467-025-57561-8","url":null,"abstract":"<p>Over the past decade, China has undergone an ambitious coal power phaseout that has induced a set of socio-economic rearrangements. To provide new insights into the socio-economic effects of this phaseout in addressing global climate change, we conducted an empirical analysis at both the macro and micro levels in China from 2014 to 2020. We found that the negative impacts of this phaseout led to 3.1% and 1.9% decreases in annual income for rural and urban populations, respectively. Despite facing macro-economic challenges, individuals report overall increased levels of happiness and life satisfaction. Collectively, these findings reveal a phenomenon in which macro socio-economic performance and subjective well-being (SWB) are driven in different directions during the phaseout. Our study uncovers potential socio-economic injustices as well as opportunities in the context of the coal power phaseout, highlighting the importance of flexibility in designing decarbonization strategies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"18 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma","authors":"Genpeng Li, Ruicen Li, Jinjing Zhong, Wenjie Chen, Jinhao Shuai, Meizhu Chen, Feng Deng, Tao Wei, Huairong Tang, Zhihui Li, Jianyong Lei","doi":"10.1038/s41467-025-57627-7","DOIUrl":"https://doi.org/10.1038/s41467-025-57627-7","url":null,"abstract":"<p>The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance (AS) express heightened regret based on validated decision regret scale (DRS) scores in the first online survey (<i>P</i> &lt; <i>0.001</i>). Multivariable analysis and the second online survey for patients with heightened regret confirm that postoperative lower thyroid cancer-specific quality of life (QoL) (scar and psychology) (75.5%) is the most common factor for heightened regret of thyroidectomy, followed by preoperative understanding of disease [not at all] (15.0%), presentation of complications (3.8%) and other factors (5.7%). These results highlight that more caution should be exercised when low-risk PTMC patients are scheduled for thyroidectomy. Information about the various treatments for clinically low-risk PTMC, the risk of thyroidectomy and postoperative QoL should be fully communicated during initial counseling.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"44 2 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary extracellular vesicle N-glycomics identifies diagnostic glycosignatures for bladder cancer","authors":"Yang Li, Bin Fu, Maoyu Wang, Weiyu Chen, Jiawei Fan, Yueyue Li, Xuejiao Liu, Jun Wang, Zhensheng Zhang, Haojie Lu, Ying Zhang","doi":"10.1038/s41467-025-57633-9","DOIUrl":"https://doi.org/10.1038/s41467-025-57633-9","url":null,"abstract":"<p>Bladder cancer (BC) is the most common urologic malignancy, facing enormous diagnostic challenges. Urinary extracellular vesicles (EVs) are promising source for developing diagnostic markers for bladder cancer because of the direct contact between urine and bladder. This study pioneers urinary EV N-glycomics for bladder cancer diagnosis. We have generated a comprehensive N-glycome landscape of urinary EVs through high-throughput N-glycome analysis, identifying a total of 252 N-glycans from 333 individuals. In bladder cancer patients, urinary EVs exhibit decreased fucosylation and increased sialylation level. An Eight N-glycan diagnostic model demonstrates strong performance in both validation cohorts, achieving ROC AUC values of 0.88 and 0.86, respectively. Furthermore, this model successfully differentiates both non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC) from healthy individuals, underscoring the model’s superiority. Moreover, urinary EVs N-glycoproteomic analysis reveals that the glycoproteins carrying cancer-associated N-glycan signatures are closely associated with immune activities. The N-glycome comparative analysis of EVs and their source cells indicate that the glycosylation profiles of EVs do not completely match the glycosylation backgrounds of their source cells. In summary, our study establishes urinary EV N-glycomics as a non-invasive BC screening tool and provide a framework for EV glycan biomarker discovery across cancers.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"17 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A transparency statement improves trust in community-police interactions","authors":"Kyle S. H. Dobson, Andrea G. Dittmann, David S. Yeager","doi":"10.1038/s41467-024-55709-6","DOIUrl":"https://doi.org/10.1038/s41467-024-55709-6","url":null,"abstract":"<p>Over the past three decades, billions have been invested in community policing to foster positive interactions between officers and community members. Yet, public trust in police continues to decline. Our qualitative analysis of over 500 hours of naturalistic observations suggests a potential reason: the questioning styles of officers in community policing may make community members feel threatened. Observations also point to a solution: transparent communication of benevolent intent. Building on this, a pre-registered field experiment (<i>N</i> = 232) finds that community members feel less threatened and report greater trust when officers use a brief transparency statement (e.g., “I’m walking around trying to get to know the community”). These findings are supported by exploratory natural language processing and sympathetic nervous system measures. Six online experiments (total <i>N</i> = 3210) further show that transparency statements are effective across diverse groups and isolate the conditions where they work best. This multi-method investigation underscores the importance of transparency in fostering positive community-police relations.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"8 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"‘I was told to toughen up’: is academia getting resilience all wrong?","authors":"","doi":"10.1038/d41586-025-00383-x","DOIUrl":"https://doi.org/10.1038/d41586-025-00383-x","url":null,"abstract":"Being repeatedly told to bounce back and develop a thicker skin can mask a toxic lab culture.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"37 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143569818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the atomistic mechanism of oxide scale spalling in heat-resistant alloys","authors":"Congcong Li, Wenjin Zheng, Haonan Zhong, Xiongjun Liu, Huihui Zhu, Hui Wang, Yuan Wu, Xiaobin Zhang, Zhiyang Yu, Suihe Jiang, Zhaoping Lu","doi":"10.1038/s41467-025-57635-7","DOIUrl":"https://doi.org/10.1038/s41467-025-57635-7","url":null,"abstract":"<p>An intact oxide scale adhering well to the matrix is crucial for the safe service of metallic materials at high temperatures. However, premature failure is usually caused by spallation of scales from the matrix. Although few mechanisms have been proposed to understand this phenomenon, consensus has not yet been reached. In this study, we reveal that trace sulfur impurities contaminated in high-purity raw materials prominently segregate to the interface and form a thin intermediate amorphous-like layer between the oxide scale and alloy matrix during the oxidation process. Subsequently, cracking and spallation occur preferentially between the sulfur-rich layer and alumina scale due to the weak bonding between sulfur and alumina atoms. We validate the revealed atomistic spalling mechanism by successfully eliminating the detrimental effect of sulfur via microalloying. Our findings are useful for improving adhesion of oxide scales and enhancing heat-resistant properties of other high-temperature alloys.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"31 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic-mediated microbial community restructuring is dictated by variability in antibiotic-induced lysis rates and population interactions","authors":"Kyeri Kim, Andrea Weiss, Helena R. Ma, Hye-In Son, Zhengqing Zhou, Lingchong You","doi":"10.1038/s41467-025-57508-z","DOIUrl":"https://doi.org/10.1038/s41467-025-57508-z","url":null,"abstract":"<p>It is widely known that faster-growing bacterial cells are more susceptible to many antibiotics. Given this notion, it appears intuitive that antibiotic treatment would enrich slower-growing cells in a clonal population or slower-growing populations in a microbial community, which has been commonly observed. However, experimental observations also show the enrichment of faster-growing subpopulations under certain conditions. Does this apparent discrepancy suggest the uniqueness about different growth environments or the role of additional confounding factors? If so, what could be the major determinant in antibiotic-mediated community restructuring? Combining modeling and quantitative measurements using a barcoded heterogeneous <i>E. coli</i> library, we show that the outcome of antibiotic-mediated community restructuring can be driven by two major factors. One is the variability among the clonal responses of different subpopulations to the antibiotic; the other is their interactions. Our results suggest the importance of quantitative measurements of antibiotic responses in individual clones in predicting community responses to antibiotics and addressing subpopulation interactions.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"67 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the measurement of high-quality development efficiency and influencing factors in the Yellow River Basin, China.","authors":"Jianhui Qin, Fen Zhang, Jiahao Zhu, Yuping Wu","doi":"10.1038/s41598-025-91944-7","DOIUrl":"https://doi.org/10.1038/s41598-025-91944-7","url":null,"abstract":"<p><p>Environmental pollution and resource scarcity characterize the Yellow River Basin. Studying the factors of high-quality development efficiency (HQDE) and its spatial correlation in the Yellow River Basin is conducive to promoting the maximization of resource allocation in the Yellow River Basin. In this study, Super-EBM and Malmquist index were used to measure HQDE in the Yellow River Basin and explore its influencing factors. The results show that: (1) HQDE is higher in cities in the upper reaches of the Yellow River Basin than in the middle and lower reaches. Compared with the degree of technology utilization, the growth of HQDE mainly depends on technological progress. (2) The spatial correlation of urban HQDE decreases has been weakened annually. The high-efficiency cities in the upper reaches of the basin are obviously concentrated, while the middle and lower reaches of the confluence have both high- and low-efficiency cities located near each other. (3) HQDE has a negative geographical spillover effect. Regression analysis shows that energy consumption, economic development level, factor endowment, public awareness of environmental protection, and enterprise green level can promote the HQDE, while foreign investment utilization, environmental pollution, and education support have negative impacts on urban HQDE.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"7928"},"PeriodicalIF":3.8,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic remodeling of complex alkenes to oxonitriles through C=C double bond deconstruction.","authors":"Zengrui Cheng, Kaimeng Huang, Chen Wang, Lili Chen, Xinyao Li, Zhibin Hu, Xinyuan Shan, Peng-Fei Cao, Haofeng Sun, Wei Chen, Chenhao Li, Ziyao Zhang, Hui Tan, Xue Jiang, Guikai Zhang, Zhongying Zhang, Min Lin, Liang Wang, Anmin Zheng, Changjiu Xia, Teng Wang, Song Song, Xingtian Shu, Ning Jiao","doi":"10.1126/science.adq8918","DOIUrl":"https://doi.org/10.1126/science.adq8918","url":null,"abstract":"<p><p>Deconstructive transformation of carbon-carbon double bonds (C=C) is a pivotal strategy in synthetic chemistry and drug discovery. Despite the substantial advances in olefin metathesis and ozonolysis for natural product synthesis through C=C double-bond cleavage, the catalytic remodeling of complex molecules through C=C double-bond deconstruction has been underdeveloped. We report a heterogeneous copper-catalyzed C=C double-bond cleavage, which enables the remodeling of complex molecules by converting the carbons on either side of the C=C double bond to carbonyl and cyano groups, respectively. In particular, this method provides an efficient protocol to conveniently transform terpenoids, glycals, steroids, and bioactive molecules to privileged scaffolds with underexplored chemical space.</p>","PeriodicalId":21678,"journal":{"name":"Science","volume":"387 6738","pages":"1083-1090"},"PeriodicalIF":44.7,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}