综合性期刊最新文献

{"title":"Sowing solutions: my quest to save Kenya’s maize from a devastating invader","authors":"","doi":"10.1038/d41586-025-01242-5","DOIUrl":"https://doi.org/10.1038/d41586-025-01242-5","url":null,"abstract":"Henry Sila Nzioki has developed a weed-killing fungus to improve food security.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"38 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143841674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microplastic pollution found in insect casing from 1971","authors":"","doi":"10.1038/d41586-025-01265-y","DOIUrl":"https://doi.org/10.1038/d41586-025-01265-y","url":null,"abstract":"Freshwater insects used ‘microplastic’ as a building material long before scientists coined the term.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"45 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Ultrastrong eutectogels engineered via integrated mechanical training in molecular and structural engineering","authors":"Chenggong Xu, Ao Xie, Haiyuan Hu, Zhengde Wang, Yange Feng, Daoai Wang, Weimin Liu","doi":"10.1038/s41467-025-59056-y","DOIUrl":"https://doi.org/10.1038/s41467-025-59056-y","url":null,"abstract":"<p>Correction to: <i>Nature Communications</i> https://doi.org/10.1038/s41467-025-57800-y, published online 16 March 2025</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"109 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-4 nanometer porous membrane enables highly efficient electrodialytic fractionation of dyes and inorganic salts","authors":"Jiuyang Lin, Zijian Yu, Tianci Chen, Junming Huang, Lianxin Chen, Jiangjing Li, Xuewei Li, Xiaolei Huang, Jianquan Luo, Elisa Yun Mei Ang, William Toh, Peng Cheng Wang, Teng Yong Ng, Dong Han Seo, Shuaifei Zhao, Kuo Zhong, Ming Xie, Wenyuan Ye, Bart Van der Bruggen, Yinhua Wan","doi":"10.1038/s41467-025-58873-5","DOIUrl":"https://doi.org/10.1038/s41467-025-58873-5","url":null,"abstract":"<p>During the synthesis of dyes, desalination of high-salinity dye-containing waste liquor is a critical premise for high-quality, clean dye production. Conventional membrane processes, such as electrodialysis, nanofiltration and ultrafiltration, are inevitably subjected to serious membrane fouling, deteriorating the dye/salt fractionation efficacy. Integrating the technical merits of electrodialysis and pressure-driven membrane separation, we devise an electro-driven filtration process using a tight ultrafiltration membrane as alternative to conventional anion exchange membrane for rapid anion transfer, in view of dye desalination and purification. By employing a sub-4 nanometer tight ultrafiltration membrane as anion conducting membrane, the electro-driven filtration process achieves 98.15% desalination efficiency and 99.66% dye recovery for one-step fractionation of reactive dye and NaCl salt, markedly outperforming the system using commercial anion exchange membranes. Notably, the electro-driven filtration system displays a consistently high and stable fractionation performance for dyes and salts with unprecedentedly low membrane fouling through an eight-cycle continuous operation. Our results demonstrate that the electro-driven filtration process using nanoporous membranes as high-performance anion conducting membranes shows a critical potential in fractionation of organic dyes and inorganic salts, unlocking the proof of concept of nanoporous membranes in electro-driven application.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"29 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual variation in the chimpanzee arcuate fasciculus predicts vocal and gestural communication","authors":"Erin E. Hecht, Suhas Vijayakumar, Yannick Becker, William D. Hopkins","doi":"10.1038/s41467-025-58784-5","DOIUrl":"https://doi.org/10.1038/s41467-025-58784-5","url":null,"abstract":"<p>Whether language has its evolutionary origins in vocal or gestural communication has long been a matter of debate. In humans, the arcuate fasciculus, a major fronto-temporal white matter tract, is left-lateralized, is larger than in nonhuman apes, and is linked to language. However, the extent to which the arcuate fasciculus of nonhuman apes is linked to vocal and/or manual communication is currently unknown. Here, using probabilistic tractography in 67 chimpanzees (45 female, 22 male), we report that the chimpanzee arcuate fasciculus is not left-lateralized at the population level, in marked contrast with humans. However, individual variation in the anatomy and leftward asymmetry of the chimpanzee arcuate fasciculus is associated with individual variation in the use of both communicative gestures and communicative sounds under volitional orofacial motor control. This indicates that the arcuate fasciculus likely supported both vocal and gestural communication in the chimpanzee/human last common ancestor, 6–7 million years ago.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"9 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Focusing a viral risk ranking tool on prediction","authors":"Katherine Budeski, Marc Lipsitch","doi":"10.1073/pnas.2419337122","DOIUrl":"https://doi.org/10.1073/pnas.2419337122","url":null,"abstract":"Preparing to rapidly respond to emerging infectious diseases is critical. <jats:italic>SpillOver: Viral Risk Ranking</jats:italic> is an open-source tool developed to assess the risk of novel wildlife-origin viruses spilling over from animals to humans and spreading in human populations. Several risk factors used by the tool depend on evidence of previous zoonotic spillover itself or sustained transmission in humans. Therefore, we reanalyzed the <jats:italic>Ranking Comparison</jats:italic> after removing eight of the 31 risk factors that require postspillover knowledge and compared the adjusted risk rankings to the originals. The area under the receiver operating characteristic curve deteriorated from 0.94 for the original risk scores to 0.73 for the adjusted ones for predicting the classification as a human virus. We also compared the mean and SD of the risk scores for the human and non-human viruses at the risk factor level. Most excluded spillover-dependent risk factors had dissimilar means between the human and non-human virus classifications, but nonspillover-dependent risk factors frequently showed similar means between the two classifications. The original formulation of the tool depended on the inclusion of spillover-dependent risk factors to quantitatively assess the risk of zoonotic spillover for a novel virus. Future iterations of the tool should omit such risk factors and consider other nonspillover-dependent risk factors to ensure that the tool is fit for risk prediction of novel viruses.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"108 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virion-associated influenza hemagglutinin clusters upon sialic acid binding visualized by cryoelectron tomography","authors":"Qiuyu J. Huang, Ryan Kim, Kangkang Song, Nikolaus Grigorieff, James B. Munro, Celia A. Schiffer, Mohan Somasundaran","doi":"10.1073/pnas.2426427122","DOIUrl":"https://doi.org/10.1073/pnas.2426427122","url":null,"abstract":"Influenza viruses are enveloped, negative-sense single-stranded RNA viruses covered in a dense layer of glycoproteins. Hemagglutinin (HA) accounts for 80 to 90% of influenza glycoprotein and plays a role in host cell binding and membrane fusion. While previous studies have characterized structures of purified receptor-free and receptor-bound HA, the effect of receptor binding on HA organization and structure on virions remains unknown. Here, we used cryoelectron tomography to visualize influenza virions bound to a sialic acid receptor mimic. Overall, receptor binding did not result in significant changes in viral morphology; however, we observed rearrangements of HA trimer organization and orientation. Compared to the even interglycoprotein spacing of unliganded HA trimers, receptor binding promotes HA trimer clustering and the formation of a triplet of trimers. Subtomogram averaging and refinement yielded 8 to 10 Å reconstructions that allowed us to visualize specific contacts between HAs from neighboring trimers and identify molecular features that mediate clustering. Taken together, we present structural evidence that receptor binding triggers clustering of HA trimers, revealing an additional layer of HA dynamics and plasticity.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"134 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulse timing dominates binaural hearing with cochlear implants.","authors":"Jan W H Schnupp,Sarah Buchholz,Alexa N Buck,Henrike Budig,Lakshay Khurana,Nicole Rosskothen-Kuhl","doi":"10.1073/pnas.2416697122","DOIUrl":"https://doi.org/10.1073/pnas.2416697122","url":null,"abstract":"Although cochlear implants (CIs) provide valuable auditory information to more than one million profoundly deaf patients, these devices remain inadequate in conveying fine timing cues. Early deaf patients in particular struggle to use interaural time differences (ITDs) for spatial hearing and auditory scene analysis. Why CI patients experience these limitations remains controversial. One possible explanation, which we investigate here, is that the stimulation by clinical CIs is inappropriate, as it encodes temporal features of sounds only in the envelope of electrical pulse trains, not the pulse timing. We have recently demonstrated that early deaf, adult implanted rats fitted with bilateral CIs that deliver carefully timed pulses routinely develop sensitivity to very small ITDs. Here we show that, while the early deafened mammalian auditory pathway can innately easily resolve pulse timing ITDs as small as 80 µs, it is many times less sensitive to the ITDs of pulse train envelopes. Our results indicate that the stimulation strategies in current clinical use do not present ITD cues in a manner that the inexperienced auditory pathway is highly sensitive to. This may deprive early deaf CI patients of the opportunity to hone their submillisecond temporal processing skills as they learn to hear through their prosthetic devices.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"30 1","pages":"e2416697122"},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to increase bedaquiline activity.","authors":"Adam J Fountain,Natalie J E Waller,Chen-Yi Cheung,William Jowsey,Michael T Chrisp,Mark Troll,Paul H Edelstein,Gregory M Cook,Matthew B McNeil,Lalita Ramakrishnan","doi":"10.1073/pnas.2426827122","DOIUrl":"https://doi.org/10.1073/pnas.2426827122","url":null,"abstract":"Bedaquiline is the cornerstone of a new regimen for the treatment of drug-resistant tuberculosis. However, its clinical use is threatened by the emergence of bedaquiline-resistant strains of Mycobacterium tuberculosis. Bedaquiline targets mycobacterial ATP synthase but the predominant route to clinical bedaquiline resistance is via upregulation of the MmpS5L5 efflux pump due to mutations that inactivate the transcriptional repressor Rv0678. Here, we show that the MmpS5L5 efflux pump reduces susceptibility to bedaquiline as well as its new, more potent derivative TBAJ-876 and other antimicrobial substrates, including clofazimine and the DprE1 inhibitors PBTZ-169 and OPC-167832. Furthermore, the increased resistance of Rv0678 mutants stems entirely from increased MmpS5L5 expression. These results highlight the potential of a pharmacological MmpS5L5 inhibitor to increase drug efficacy. Verapamil, primarily used as a calcium channel inhibitor, is known to inhibit diverse efflux pumps and to potentiate bedaquiline and clofazimine activity in M. tuberculosis. Here, we show that verapamil potentiates the activity of multiple diverse MmpS5L5 substrates. Using biochemical approaches, we demonstrate that verapamil does not exert this effect by acting as a disruptor of the protonmotive force used to power MmpS5L5, as previously proposed, suggesting that verapamil inhibits the function of the MmpS5L5 pump. Finally, norverapamil, the major verapamil metabolite, which has greatly reduced calcium channel activity, has equal potency in reducing resistance to MmpS5L5 substrates. Our findings highlight verapamil's potential for enhancing bedaquiline TB treatment, for preventing acquired resistance to bedaquiline and other MmpS5L5 substrates, while also providing the impetus to identify additional MmpS5L5 inhibitors.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"7 1","pages":"e2426827122"},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of John Hopfield and Geoffrey Hinton: 2024 Nobel laureates in physics.","authors":"James L McClelland","doi":"10.1073/pnas.2423094122","DOIUrl":"https://doi.org/10.1073/pnas.2423094122","url":null,"abstract":"The 2024 Nobel Prize in Physics recognizes breakthroughs contributing to the emergence of a new understanding of the computations that underlie human intelligence, with profound implications for artificially intelligent systems. John Hopfield and Geoffrey Hinton played seminal roles in these breakthroughs. I begin by characterizing the scientific context in which the new understanding of intelligence began to arise. I then consider Hopfield's and Hinton's ideas and their centrality in the sciences of natural and artificial intelligence, while mentioning others who made major contributions. I conclude with a brief consideration of the current state of the fields these ideas have influenced and of the importance of governmental and scientific organizations in the past and future of these sciences.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"30 1","pages":"e2423094122"},"PeriodicalIF":11.1,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143846319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}