综合性期刊最新文献

{"title":"Capillary constrictions prime cancer cell tumorigenicity through PIEZO1","authors":"Giulia Silvani, Chantal Kopecky, Sara Romanazzo, Vanina Rodríguez, Ayan Das, Elvis Pandzic, John G. Lock, Christine L. Chaffer, Kate Poole, Kristopher A. Kilian","doi":"10.1038/s41467-025-63374-6","DOIUrl":"https://doi.org/10.1038/s41467-025-63374-6","url":null,"abstract":"<p>Metastasis is responsible for most cancer-related deaths. However, only a fraction of circulating cancer cells succeed in forming secondary tumours, indicating that adaptive mechanisms during circulation play a part in dissemination. Here, we report that constriction during microcapillary transit triggers reprogramming of melanoma cells to a tumorigenic cancer stem cell-like state. Using a microfluidic device mimicking physiological flow rates and gradual capillary narrowing, we show that compression through narrow channels causes cell and nuclear deformation, rapid chromatin remodelling and increased calcium signalling via mechanosensor PIEZO1. Within minutes, cells upregulate transcripts associated with metabolic reprogramming and metastatic processes. Over time, this results in the stable adoption of a cancer stem cell-like state. Squeezed cells express elevated melanoma stem cell markers, exhibit increased trans-endothelium invasion and display enhanced tumorigenicity in vitro and in vivo. Pharmacological inhibition of PIEZO1 blocks this transition, while activation with Yoda1 induces the stem cell-like state irrespective of constriction. Deletion of PIEZO1 completely abolishes the constriction-induced phenotype. Together, these findings demonstrate that compressive forces during circulation reprogram circulating cancer cells into tumorigenic, stem cell-like states, primed for extravasation and metastatic colonization.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"27 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated lithium niobate photonic computing circuit based on efficient and high-speed electro-optic conversion","authors":"Yaowen Hu, Yunxiang Song, Xinrui Zhu, Xiangwen Guo, Shengyuan Lu, Qihang Zhang, Lingyan He, Cornelis A. A. Franken, Keith Powell, Hana Warner, Daniel Assumpcao, Dylan Renaud, Ying Wang, Letícia Magalhães, Victoria Rosborough, Amirhassan Shams-Ansari, Xudong Li, Rebecca Cheng, Kevin Luke, Kiyoul Yang, George Barbastathis, Mian Zhang, Di Zhu, Leif Johansson, Andreas Beling, Neil Sinclair, Marko Lončar","doi":"10.1038/s41467-025-62635-8","DOIUrl":"https://doi.org/10.1038/s41467-025-62635-8","url":null,"abstract":"<p>The surge in artificial intelligence applications calls for scalable, high-speed, and low-energy computation methods. Computing with photons is promising due to the intrinsic parallelism, high bandwidth, and low latency of photons. However, current photonic computing architectures are limited by the speed and energy consumption associated with electronic-to-optical data transfer, i.e., electro-optic conversion. Here, we demonstrate a thin-film lithium niobate (TFLN) computing circuit that addresses this challenge, leveraging both highly efficient electro-optic modulation and the spatial scalability of TFLN photonics. Our circuit is capable of computing at 43.8 GOPS/channel while consuming 0.0576 pJ/OP, and we demonstrate various inference tasks with high accuracy, including the classification of binary data and complex images. Heightening the integration level, we show another TFLN computing circuit that is combined with a hybrid-integrated distributed-feedback laser and heterogeneous-integrated modified uni-traveling carrier photodiode. Our results show that the TFLN photonic platform holds promise to complement silicon photonics and diffractive optics for photonic computing, with extensions to ultrafast signal processing and ranging.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"302 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer’s disease mouse model","authors":"Jack I. Wood, Maciej Dulewicz, Alicja Szadziewska, Sophia Weiner, Junyue Ge, Katie Stringer, Sneha Desai, Lydia Fenson, Diana Piotrowska, Gunnar Brinkmalm, Srinivas Koutarapu, Haady B. Hajar, Kaj Blennow, Henrik Zetterberg, Damian M. Cummings, Jeffrey N. Savas, Frances A. Edwards, Jörg Hanrieder","doi":"10.1038/s41467-025-63328-y","DOIUrl":"https://doi.org/10.1038/s41467-025-63328-y","url":null,"abstract":"<p>Understanding how amyloid beta (Aβ) plaques develop and lead to neurotoxicity in Alzheimer’s disease remains a major challenge, particularly given the temporal delay and weak correlation between plaque deposition and cognitive decline. This study investigates how the evolving pathology of plaques affects the surrounding tissue, using a knock-in Aβ mouse model (<i>App</i>^{<i>NL-F/NL-F</i>}). We combined mass spectrometry imaging with stable isotope labeling to timestamp Aβ plaques from the moment of their initial deposition, enabling us to track their aging spatially. By integrating spatial transcriptomics, we linked changes in gene expression to the age of the plaques, independent of the mice’s chronological age or disease stage. Here we show that older plaques were associated with reduced expression of synaptic genes. Additionally, when correlated with structure-specific dyes, we show that plaque age positively correlated with structural maturation. These more compact and older plaques were linked to greater synapse loss and increased toxicity.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"14 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Catalytic aromatic C−H borylation via strained Si and Ge metallacycles","authors":"Qianwei Chen, Minyan Wang, Yue Zhao, Zhuangzhi Shi","doi":"10.1038/s41467-025-63335-z","DOIUrl":"https://doi.org/10.1038/s41467-025-63335-z","url":null,"abstract":"<p>Arenes bearing silyl and boryl, or germyl and boryl groups, represent a significant class of bifunctional molecules that have garnered considerable attention in organic synthesis due to their unique reactivity and versatility in undergoing diverse chemical transformations. Despite their importance, the synthesis of these mixed-metalloid compounds, particularly those with <i>ortho</i>-substituted aromatic frameworks, often involves complex, multi-step procedures. Herein, we present a highly efficient, single-step method for synthesizing <i>ortho</i>-boronated arylhydrosilanes and arylgermanes via catalytic C−H borylation reaction. The use of Si- and Ge-containing directing groups has been demonstrated to effectively suppress undesirable metathesis reactions, a side effect typically associated with their metallic nature. Our approach employs an iridium catalyst in combination with a ligand and an acetate base, which facilitates the formation of benzo-fused four-membered metallacycles within the catalytic cycle. The method’s broad applicability and practicality are further underscored by its ability to generate a wide array of valuable intermediates that can be easily transformed into various functionalized molecules. Both experimental and computational studies provide profound insights into the reaction dynamics and the factors influencing the formation of these strained metallacycles.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"13 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome data integration via shared dictionary learning","authors":"Bo Yuan, Shulei Wang","doi":"10.1038/s41467-025-63425-y","DOIUrl":"https://doi.org/10.1038/s41467-025-63425-y","url":null,"abstract":"<p>Data integration is a powerful tool for facilitating a comprehensive and generalizable understanding of microbial communities and their association with outcomes of interest. However, integrating data sets from different studies remains a challenging problem because of severe batch effects, unobserved confounding variables, and high heterogeneity across data sets. We propose a new data integration method called MetaDICT, which initially estimates the batch effects by weighting methods in causal inference literature and then refines the estimation via novel shared dictionary learning. Compared with existing methods, MetaDICT can better avoid the overcorrection of batch effects and preserve biological variation when there exist unobserved confounding variables, data sets are highly heterogeneous across studies, or the batch is completely confounded with some covariates. Furthermore, MetaDICT can generate comparable embedding at both taxa and sample levels that can be used to unravel the hidden structure of the integrated data and improve the integrative analysis. Applications to synthetic and real microbiome data sets demonstrate the robustness and effectiveness of MetaDICT in integrative analysis. Using MetaDICT, we characterize microbial interaction, identify generalizable microbial signatures, and enhance the accuracy of outcome prediction in two real integrative studies, including an integrative analysis of colorectal cancer metagenomics studies and a meta-analysis of immunotherapy microbiome studies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"23 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrahigh pressure compaction-resistant thin film crosslinked composite reverse osmosis membranes","authors":"Jishan Wu, Javier A. Quezada-Renteria, Jinlong He, Minhao Xiao, Yuanmiaoliang Chen, Hanqing Fan, Xinyi Wang, Fiona Chen, Kevin Pataroque, Yara Suleiman, Sina Shahbazmohamadi, N. A. Sreejith, Hariswaran Sitaraman, Marc Day, Ying Li, David Jassby, Jeffrey R. McCutcheon, Menachem Elimelech, Eric M. V. Hoek","doi":"10.1038/s41467-025-63639-0","DOIUrl":"https://doi.org/10.1038/s41467-025-63639-0","url":null,"abstract":"<p>In this study, we present a class of thin-film crosslinked (TFX) composite reverse osmosis (RO) membranes that resist physical compaction at ultrahigh pressures (up to 200 bar). Since RO membranes experience compaction at virtually all pressure ranges, the ability to resist compaction has widespread implications for RO membrane technology. The process described herein involves crosslinking a phase inverted porous polyimide (PI) support membrane followed by interfacial polymerization of a polyamide layer, thereby forming a fully thermoset composite membrane structure. We explore a range of phase inversion membrane formation parameters such as PI concentration, solvent-cosolvent ratios, coagulation bath composition, and crosslinking methods in addition to interfacial polymerization reaction chemistry and conditions. Overall, TFX membranes exhibit significantly less compaction compared to hand-cast and commercial high-pressure RO membranes, experiencing less than 10% decline in water permeance and maintaining salt rejection over 99% for NaCl solutions up to 180,000 mg/L with 200 bar applied pressure.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"84 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation factor XII haploinsufficiency is protective against venous thromboembolism in a population-scale multidimensional analysis","authors":"Amelia K. Haj, David S. Paul, Sean J. Jurgens, Harish Eswaran, Lu-Chen Weng, Justine Ryu, Alfonso Rodriguez Espada, Sharjeel Chaudhry, Louis M. Feingold, Kristen Burke, Satoshi Koyama, Xin Wang, Joyce Francis, Seung Hoan Choi, Nigel Mackman, Wolfgang Bergmeier, Alex Burgin, Joel T. Rämö, Patrick T. Ellinor, Steven P. Grover, Pavan K. Bendapudi","doi":"10.1038/s41467-025-62789-5","DOIUrl":"https://doi.org/10.1038/s41467-025-62789-5","url":null,"abstract":"<p>Coagulation factor XII has been identified as a potential drug target that could prevent thrombosis without increasing the risk of bleeding. However, human data to support the development of factor XII-directed therapeutics are lacking. To assess the role of factor XII in venous thromboembolism, we examine genetic variation in the coding region of the <i>F12</i> locus across 703,745 participants in the UK Biobank and NIH All of Us biorepositories. We find that heterozygous carriers of nonsense, frameshift, and essential splice site variants in <i>F12</i> are protected against venous thromboembolism without an increased risk of bleeding or infection. We also show that <i>F12</i> variant carriers generally experience a quantitative (type I) defect in circulating factor XII levels, though a subset of participants was also identified with possible qualitative (type II) deficiency. In vitro plasma-based thrombin generation is reduced at factor XII concentrations reflective of those seen in <i>F12</i> variant carriers. We also show that <i>F12</i> heterozygous mice are protected against venous thromboembolism and display an intermediate phenotype between wild-type and <i>F12</i>-null animals. We conclude that heterozygous loss of <i>F12</i> represents a haploinsufficient state characterized by protection against venous thromboembolism and that therapeutically inhibiting factor XII is likely to be safe and effective.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"42 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-sensitivity and fast-response solar-blind photodetectors via band offset engineering for motion tracking","authors":"Hongbin Wang, Cheng Zhou, Peng Li, Lin Yang, Jiangang Ma, Ryota Akaike, Hideto Miyake, Haiyang Xu, Yichun Liu","doi":"10.1038/s41467-025-63683-w","DOIUrl":"https://doi.org/10.1038/s41467-025-63683-w","url":null,"abstract":"<p>Single-pixel imaging is emerging as a promising alternative to traditional focal plane array technologies, offering advantages in compactness and cost-effectiveness. However, the lack of solar-blind photodetectors combining fast-response and high-sensitivity has constrained their application in the deep ultraviolet spectrum. This work introduces a self-powered solar-blind photodetector based on a heterostructure comprising a Ga₂O₃ photosensitive layer, an AlN barrier layer, and an N-polar AlGaN:Si contact layer. The polarization field within the AlN layer induces band bending, creating potential wells that confine photogenerated holes and thereby generate photocurrent gain. Consequently, the Ga₂O₃/AlN/AlGaN:Si solar-blind photodetector achieves a high responsivity of 0.73 A W^‒1 and a rapid decay time of 56 µs. This performance enables 256 × 256 resolution solar-blind single-pixel imaging of both static fingerprints and moving objects. The proposed band offset engineering strategy opens a pathway for developing solar-blind photodetectors and solar-blind imaging technologies.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"8 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near-global spawning strategies of large pelagic fish","authors":"Kristine Camille V. Buenafe, Sandra Neubert, Kylie L. Scales, Daniel C. Dunn, Jason D. Everett, Jason Flower, Iain M. Suthers, Pablo Granados-Dieseldorff, Alvise Dabalà, Kris Jypson T. Esturas, James Mercer, Anthony J. Richardson","doi":"10.1038/s41467-025-63106-w","DOIUrl":"https://doi.org/10.1038/s41467-025-63106-w","url":null,"abstract":"<p>Understanding the spawning strategies of large pelagic fish could provide insights into their underlying evolutionary drivers, but large-scale information on spawning remains limited. Here we leverage a near-global larval dataset of 15 large pelagic fish taxa to develop habitat suitability models and use these as a proxy for spawning grounds. Our analysis reveals considerable consistency in spawning in time and space, with 10 taxa spawning in spring/summer and 9 taxa spawning off Northwest Australia. Considering the vast ocean expanse available for spawning, these results suggest that the evolutionary benefits of co-locating spawning in terms of advantageous larval conditions outweigh the benefits of segregated spawning in terms of reduced competition and lower larval predation. Further, tropical species spawn over broad areas throughout the year, whereas more subtropical and temperate species spawn in more restricted areas and seasons. These insights into the spawning strategies of large pelagic fish could inform marine management, including through fisheries measures to protect spawners and through the placement of marine protected areas.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"83 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144928493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marble and granite as natural radiation sources: Risk assessment and their impact on health and the environment","authors":"Mossad A. Salama ,&nbsp;Korany A. Korany ,&nbsp;Mohammed Ezzeldien","doi":"10.1016/j.jrras.2025.101901","DOIUrl":"10.1016/j.jrras.2025.101901","url":null,"abstract":"<div><div>Driven by growing public health concerns and limited regional data, this study investigates natural radioactivity and associated radiological hazards in marble and granite widely used in Al-Jouf, Saudi Arabia. Twenty-eight marble and thirty granite samples were systematically collected and analyzed via gamma-ray spectrometry using a high-purity germanium (HPGe) detector. The mean activity concentrations (±SD) for marble were 14.82 ± 10.63 Bq/kg (²²⁶Ra), 16.54 ± 8.53 Bq/kg (²³²Th), and 78.61 ± 41.64 Bq/kg (⁴⁰K). For granite, the values were 28.58 ± 19.89 Bq/kg, 37.04 ± 27.35 Bq/kg, and 960.48 ± 494.08 Bq/kg, respectively. Key hazard indices showed mean values for marble of radium equivalent activity (Ra_eq) 38 ± 19.36 Bq/kg, external hazard index (H_ex) 0.10 ± 0.05, internal hazard index (H_in) 0.15 ± 0.07, and representative gamma index (I_γ) 0.27 ± 0.13. For granite, the mean values were Ra_eq 151.14 ± 92.75 Bq/kg, H_ex 0.41 ± 0.25, H_in 0.48 ± 0.3, and I_γ 1.16 ± 0.7. The mean annual indoor effective dose equivalent (AEDE) was 0.087 ± 0.042 mSv/y for marble and 0.363 ± 0.219 mSv/y for granite—both below the public exposure limit of 1 mSv/y—although some granite samples exceeded the recommended gamma index threshold due to elevated potassium content. Most marble samples were deemed radiologically safe for construction, while certain granite varieties may require additional processing or regulatory oversight.</div><div>This work provides the first comprehensive radiological baseline for building stones in Al-Jouf, supporting material safety regulations and public health protection.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 4","pages":"Article 101901"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}