综合性期刊最新文献

{"title":"Mapping the distribution of phlebotomine sand fly species with emphasis on Leishmania vectors in Nepal and exploring the potential of DNA barcoding for their identification.","authors":"Lalita Roy, Surendra Uranw, Keshav Rai, Kristien Cloots, Murari Lal Das, Nathalie Smitz, Wim Van Bortel","doi":"10.1038/s41598-025-20276-3","DOIUrl":"https://doi.org/10.1038/s41598-025-20276-3","url":null,"abstract":"<p><p>Nepal is committed to eliminating visceral leishmaniasis as a public health problem by 2030. The scattered distribution of VL cases across wide geo-ecological regions, including areas previously considered unsuitable for the survival of vectors and the transmission of the pathogen, poses a major threat to Nepal's national VL elimination programme. Regular monitoring and accurate identification of sand fly species are essential for implementing tailored vector control interventions. Hence, this study aimed to update the distribution of sand fly species with a focus on Leishmania vectors and evaluate DNA barcoding as a complementary tool for their identification. Sand flies were collected from 43 districts with active VL cases across the country between 2017 and 2022. The mitochondrial COI gene was amplified for DNA barcoding analysis. The primary vector, Phlebotomus argentipes, was present in all except three districts. Potential vectors, Ph. (Adlerius) spp. and Ph. major, were found common in high-altitude regions. The species identification success rate of generated COI barcode sequences based on the \"Best Close Match\" was 97%, indicating high accuracy in delineating sand flies to the species level. The information on the distribution of phlebotomine sand flies and the potential use of DNA barcoding for their identification could be milestones for sand fly research and help to guide the vector control interventions in support of VL elimination in Nepal.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"36356"},"PeriodicalIF":3.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perpendicular magnetic anisotropy in a single Dy adatom ferrimagnet.","authors":"Alexander B Shick, Frantisek Maca, Itzhak Halevy, Dominik Legut","doi":"10.1038/s41598-025-20466-z","DOIUrl":"https://doi.org/10.1038/s41598-025-20466-z","url":null,"abstract":"<p><p>The electronic structure and magnetism of individual Dy atoms adsorbed on ferromagnetic (Gr)/Ni(111) substrate are investigated using a combination of the density functional theory with the Hubbard-I approximation to the Anderson impurity model (DFT+U(HIA)). The divalent Dy[Formula: see text] adatom in [Formula: see text] configuration with [[Formula: see text]] is found. The values of spin [Formula: see text]=3.4 [Formula: see text], orbital [Formula: see text]=5.2 [Formula: see text], and total [Formula: see text]=8.6 [Formula: see text] magnetic moments calculated for the Dy f-shell are noticeably different from the atomic second Hund's rule. There is almost zero moment on (Gr)-atoms. The ferromagnetic Ni substrate moments are anti-aligned to the Dy 4f-shell moment. The X-ray absorption (XAS) and magnetic circular dichroism (XMCD) spectra are calculated and can be compared to the experimental data. The magnetic anisotropy energy (MAE) is calculated from the ground state energy difference for different directions of the magnetization, E[100] - E[001] = 3.5 meV and E[010] - E[001] = 2.2 meV. This large and positive MAE can be important for ultra-high density magnetic recording. The magnetization of Dy@(Gr)/Ni(111) is tilted with respect to the (Gr)/Ni(111) substrate normal by [Formula: see text] due to a competition between negative first and third order magnetic anisotropies and strong and positive second order magnetic anisotropies. Our studies assist in resolving ambiguities of conventional DFT+U applied to Dy on graphene. They can provide a viable route for further investigation and prediction of the rare-earth based magnetic nanostructures.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"36387"},"PeriodicalIF":3.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric properties of the perception of telework practices (PTP) scale: measuring advantages and drawbacks in the Lebanese context.","authors":"Hala Sacre, Chadia Haddad, Maha Zakhour, Joanne Karam, Marwan Akel, Sami El Khatib, Pascale Salameh","doi":"10.1038/s41598-025-20334-w","DOIUrl":"https://doi.org/10.1038/s41598-025-20334-w","url":null,"abstract":"<p><p>Telework, also known as remote work or telecommuting, has become increasingly prevalent in modern work environments, especially in response to global events such as the COVID-19 pandemic, reshaping traditional work practices and prompting questions about its impact on various aspects of work life, including the perceived advantages and drawbacks. This study aimed to develop and validate a scale that assesses the benefits and disadvantages of remote working. A web-based cross-sectional study was conducted between October 2022 and March 2023 using a self-report questionnaire. Snowball sampling enabled the enrollment of 230 participants aged 20 to 80, divided into three categories based on their employment type: face-to-face, telework, and hybrid. The exploratory factor analysis of the perception of telework practices total scale produced two subscales (subscale 1: Perceived Drawbacks and subscale 2: Perceived Advantages of Telework Practices). The advantages/drawbacks of telework were positively correlated with each other and with their own factors. A significant, weak, but positive correlation was found between telework drawback and advantage scores (r = 0.266, p < 0.001). Moreover, a positive correlation was also found between the E-Work Life (EWL) subscales and the Perceived Advantages of Telework Practices. The Perceived Drawbacks scale was overall less associated with the EWL satisfaction subscale, and no significant correlation was found with productivity or flexibility. This study developed and validated the Perception of Telework Practices (PTP) scale with excellent psychometric properties. The validated scale measures telework perceptions in developing country contexts, supporting evidence-based policy and organizational decisions in modern workplaces.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"36437"},"PeriodicalIF":3.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatio-temporal patterns, trends, and oceanographic drivers of whale shark strandings in Indonesia.","authors":"Mochamad Iqba Herwata Putra, Anindya Wirasatriya, Haidar Asyraffauzan, Fahmi, Ismail Syakurachman, Abdi Hasan, Hanggar Prasetio, Abraham Sianipar, Edy Setyawan, Prabowo Prabowo, Muhammad Subhan Wattiheluw, Arief Edy Handoyo, Muhammad Firdaus Agung Kunto Kurniawan, Mark V Erdmann, Jatna Supriatna, Masita Dwi Mandini Manessa","doi":"10.1038/s41598-025-20543-3","DOIUrl":"https://doi.org/10.1038/s41598-025-20543-3","url":null,"abstract":"<p><p>Despite the increased international attention to whale shark conservation, their populations remain predominantly depleted due to anthropogenic activities such as fishing, ship collisions, and marine pollution. Reports of whale shark strandings in Indonesia have been increasing in recent years, elevating concerns regarding their well-being and the potential disturbance to their population recovery. However, limited understanding of stranding patterns, trends, and the oceanographic factors potentially driving these events has resulted in efforts focusing primarily on responding to strandings rather than implementing effective mitigation strategies. Using a 13-year stranding dataset (n = 115) obtained from open-access databases, reports, news, and publications, we examined the characteristics of stranding cases in Indonesia, including population demographics, where hotspots occur, and whether their occurrence is related to oceanographic dynamics in the region. Our study highlights significant population-level disturbances, with 70% of stranded individuals being large juveniles (4-7 m). It also documented a positive interannual trend in stranding cases (R² = 0.67, p < 0.01). The southern coast of Java has emerged as a stranding hotspot, with events seasonally associated with strong upwelling, likely related to the seasonal foraging activities of whale sharks in the region. Although natural events were identified as the main factors contributing to whale shark strandings, anthropogenic activities may also play an important role and require further investigation.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"36435"},"PeriodicalIF":3.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Raman spectroscopy and machine learning for early detection of gastric cancer and Helicobacter pylori with gastric juice.","authors":"Weiwei Fu, Yuxin Zhang, Kangle Zhai, Jing Zhang, Yue Wen, Yingli Xu, Jing Zhang, Jing Wang, Shigang Ding","doi":"10.1038/s41598-025-20270-9","DOIUrl":"https://doi.org/10.1038/s41598-025-20270-9","url":null,"abstract":"<p><p>Gastric cancer is a leading cause of cancer-related mortality and highlights the need for early detection of gastric cancer and Helicobacter pylori (HP) infection, which is a major risk factor. Early non-invasive and convenient diagnostic tools capable of capturing the dynamic molecular alterations during carcinogenesis and HP infection is needed. In this study, we use Raman spectroscopy and machine learning algorithms to detect different gastric lesions and HP infection condition with gastric juice samples. 133 patients from Peking University Third Hospital were involved and categorized into groups based on histopathological diagnosis: early gastric cancer (EGC), dysplasia (DYS), intestinal metaplasia (IM), and chronic superficial gastritis (CSG), with further classification based on HP infection. The stacked machine learning model demonstrated high diagnostic performance, achieving 90% accuracy, 90% sensitivity, and 97% specificity in distinguishing pathological stages, along with 96% accuracy, 96% sensitivity, and 96% specificity in HP detection. The multilayer perceptron (MLP) model based on gastric juice Raman spectroscopy showed excellent discrimination capability, with an AUC of 0.98 for differentiating controls from patients with DYS and EGC. Additionally, Raman spectroscopy achieved an AUC of 0.95 in distinguishing control gastric mucosa from precancerous lesions (IM, DYS) and EGC. The approach offers a rapid, accurate, and minimally invasive diagnostic tool, demonstrating significant potential for clinical application in rapid and accurate detection of precancerous lesions, early gastric cancer, and HP infection.</p>","PeriodicalId":21811,"journal":{"name":"Scientific Reports","volume":"15 1","pages":"36332"},"PeriodicalIF":3.9,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis","authors":"Atsuki Nakano,&nbsp;Jun-ichi Kishikawa,&nbsp;Nishida Yui,&nbsp;Kyosuke Sugawara,&nbsp;Yuto Kan,&nbsp;Christoph Gerle,&nbsp;Hideki Shigematsu,&nbsp;Kaoru Mitsuoka,&nbsp;Ken Yokoyama","doi":"10.1126/sciadv.adx8771","DOIUrl":"10.1126/sciadv.adx8771","url":null,"abstract":"<div >ATP synthases are rotary molecular machines that use the proton motive force to rotate the central rotor complex relative to the surrounding stator apparatus, thereby coupling the ATP synthesis. We reconstituted the V/A-ATPase into liposomes and performed structural analysis using cryo-EM under conditions where the proton motive force was applied in the presence of ADP and Pi. ATP molecules were bound at two of the three catalytic sites of V/A-ATPase, confirming that the structure represents a state adopted during ATP synthesis. In this structure, the catalytic site closes upon binding of ADP and Pi through an induced fit mechanism. Multiple structures were obtained where the membrane-embedded rotor ring was in a different position relative to the stator. By comparing these structures, we found that torsion occurs in both the central rotor and the peripheral stator during 31° rotation of rotor ring. These structural snapshots of V/A-ATPase provide crucial insights into the mechanism of rotary catalysis of ATP synthesis.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 42","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx8771","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CysMP reveals metal ion–specific metalloproteomes and copper-regulated PGK1 activity in glycolysis","authors":"Yamei Yuan,&nbsp;Zhiyuan Wang,&nbsp;Chenfang Si,&nbsp;Jianlong Li,&nbsp;Fandong Ren,&nbsp;Yi Yuan,&nbsp;Ziqi Shi,&nbsp;Nana Sun,&nbsp;Xiaonuo Ma,&nbsp;Xingbang Dai,&nbsp;Yunxia Li,&nbsp;Yixiao Zhang,&nbsp;Jianping Liu,&nbsp;Hongbin Wang,&nbsp;Zhengjiang Zhu,&nbsp;Bing Shan,&nbsp;Yaoyang Zhang","doi":"10.1126/sciadv.adx7035","DOIUrl":"10.1126/sciadv.adx7035","url":null,"abstract":"<div >Metal ions are essential in regulating protein functions through interactions with residues such as cysteine, but comprehensive mapping of metal-specific metalloproteomes in mammals remains limited. Here, we introduce CysMP, a cysteine-centered metalloprotein profiling strategy to profile the metalloproteomes of 11 key metal ions. CysMP identified 8895 metal-binding sites across 4150 proteins, enabling quantitative comparisons between different metals and revealing both their binding promiscuity and preferences. Notably, zinc and copper ions exhibit the broadest protein interaction profiles. CysMP uncovers numerous potential metalloproteins. We demonstrate that copper and zinc bind to and inhibit 5′-methylthioadenosine phosphorylase, resulting in the accumulation of 5′-methylthioadenosine. Furthermore, copper binding suppresses phosphoglycerate kinase 1 activity, leading to a down-regulation of glycolysis. Our work not only establishes a valuable resource for a dual-specific metalloproteome database but also paves the way for understanding the molecular insights of metalloprotein functions.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 42","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adx7035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness","authors":"Elan L’Estrange-Stranieri,&nbsp;Timothy A. Gottschalk,&nbsp;Anne M. Kong,&nbsp;Mhairi J. Maxwell,&nbsp;Ee Shan Pang,&nbsp;Evelyn Tsantikos,&nbsp;David M. Tarlinton,&nbsp;Meredith O’Keeffe,&nbsp;Mark D. Wright,&nbsp;Margaret L. Hibbs","doi":"10.1126/sciadv.adz1726","DOIUrl":"10.1126/sciadv.adz1726","url":null,"abstract":"<div >Lyn phosphorylates inhibitory immunoreceptors to terminate signaling; consequently, Lyn deficiency in mice causes hyperactive immune cells and lupus-like autoimmune disease. Lyn may also suppress autoimmunity independent of its kinase activity through inhibitory protein-protein binding interactions, although the importance of this mechanism is unclear. To analyze the kinase-independent functions of Lyn, mice expressing a catalytically inactive mutant of Lyn were generated and their phenotype compared to Lyn-deficient mice. Disease progression was blunted in Lyn kinase-dead mice indicating a contribution for kinase-independent Lyn functions in restraining autoantibody production, glomerulonephritis, Toll-like receptor signaling, and splenomegaly. Further comparative analyses identified an exclusive role for the kinase-dependent functions of Lyn in regulating B cell receptor signaling, dendritic cell phenotype, and type I interferon production. By contrast, interferon-stimulated gene expression and the regulation of thymic epithelial cell development and T cell selection are previously unidentified, exclusively kinase-independent functions for Lyn. Collectively, these findings further our understanding of the nuanced roles of Lyn in health and disease.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 42","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adz1726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CEP76 impairment at the centrosome-cilium interface contributes to a spectrum of ciliopathies","authors":"Kamal Khan,&nbsp;Erika Tavares,&nbsp;Katherine Bishara,&nbsp;Aysegul Ozanturk,&nbsp;Leila Qebibo,&nbsp;Stephan Frangakis,&nbsp;Daniel G. Calame,&nbsp;Isabelle Meunier,&nbsp;Béatrice Bocquet,&nbsp;Rafal Ploski,&nbsp;Mohammad Ayman Al Khateeb,&nbsp;Dana Marafi,&nbsp;Luke Mansard,&nbsp;Lena Damaj,&nbsp;Richard A. Lewis,&nbsp;Farid Ullah,&nbsp;Thomas Arbogast,&nbsp;Jackson P. Ogden,&nbsp;Madeleine Harion,&nbsp;Marjolaine Willems,&nbsp;Maha S. Zaki,&nbsp;Tobias Bartolomaeus,&nbsp;Anne-Françoise Roux,&nbsp;James R. Lupski,&nbsp;Malgorzata Rydzanicz,&nbsp;Rami Abou Jamra,&nbsp;Francis Ramond,&nbsp;Elise Heon,&nbsp;Lydie Burglen,&nbsp;Erica E. Davis","doi":"10.1126/sciadv.adw3717","DOIUrl":"10.1126/sciadv.adw3717","url":null,"abstract":"<div >Dysfunction at the centrosome-cilium interface underlies a broad range of ciliopathies. Here, we identify biallelic variants in <i>CEP76</i>, encoding a centrosomal protein, in eight unrelated individuals presenting with neurodevelopmental, ocular, and variable additional multisystem features. Proband-derived fibroblasts and CEP76-depleted RPE1 cells display ciliary deficits, including impaired cilium formation and length, disrupted transition zone architecture, and impaired IFT88-mediated anterograde intraflagellar transport. Zebrafish <i>cep76</i> mutants recapitulate key clinical phenotypes, and in vitro complementation assays confirm pathogenicity for all tested human disease-associated variants. Proteomics analysis identifies CEP76 interactors, including known partners CCP110 and CEP97, and highlights clinically and functionally relevant candidates, including ALMS1 and LUZP1. Together, these findings expand the role of CEP76 beyond centriole duplication to include ciliary assembly and trafficking, establishing it as a ciliopathy gene. This work provides mechanistic insights into <i>CEP76</i>-related disease and broadens our understanding of centrosome-cilium biology.</div>","PeriodicalId":21609,"journal":{"name":"Science Advances","volume":"11 42","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.science.org/doi/reader/10.1126/sciadv.adw3717","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a loaded change of direction training program on physical performance in U-19 elite soccer players.","authors":"Víctor Martín, Mehdi Ben Brahim, Ariadna Hernaiz-Sánchez, Hussain Yassin, Alejandro Sal-de-Rellán","doi":"10.1371/journal.pone.0335148","DOIUrl":"10.1371/journal.pone.0335148","url":null,"abstract":"<p><p>Changes of direction are one of the most repeated actions during football matches, which is why the inclusion of these actions in the training of the football player must be a fundamental aspect. The aim of this study was to assess the effects of 6-week a loaded change of direction (COD) movements training on speed, jump, COD speed, and repeated sprint ability (RSA) in soccer players. Twenty-eight male soccer players (age: 19.12 ± 0.75 years; height: 1.75 ± 0.06 m; body mass: 72.78 ± 4.87 kg; systematic practice: 8.62 ± 1.33 years) were randomly assigned to an experimental group (EG, n = 14) or a control group (CG, n = 14). The research was conducted during a training camp. During the intervention period, the EG performed two weekly sessions of loaded change of direction training, while the CG performed FIFA 11 prevention program. EG significantly improved the performance of 5-m, CMJ, SJ, Illinois and the percentage of decrement (%Dec and %Dec-COD). However, CG only showed significant improvements in CMJ and SJ. Between-groups analysis revealed differences in favor of the EG in 5-m, CMJ, SJ. The main results show that the effect of loaded COD movements training using a weighted vest on the physical performance of soccer players is significantly greater compared to the FIFA 11 prevention program. This study shows that including an additional load in COD exercises is a good method to increase performance on key variables for soccer players.</p>","PeriodicalId":20189,"journal":{"name":"PLoS ONE","volume":"20 10","pages":"e0335148"},"PeriodicalIF":2.6,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533869/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}