综合性期刊最新文献

{"title":"Long COVID after SARS-CoV-2 during pregnancy in the United States","authors":"Chengxi Zang, Daniel Guth, Ann M. Bruno, Zhenxing Xu, Haoyang Li, Nariman Ammar, Robert Chew, Nick Guthe, Emily Hadley, Rainu Kaushal, Tanzy Love, Brenda M. McGrath, Rena C. Patel, Elizabeth C. Seibert, Yalini Senathirajah, Sharad Kumar Singh, Fei Wang, Mark G. Weiner, Kenneth J. Wilkins, Yiye Zhang, Torri D. Metz, Elaine Hill, Thomas W. Carton","doi":"10.1038/s41467-025-57849-9","DOIUrl":"https://doi.org/10.1038/s41467-025-57849-9","url":null,"abstract":"<p>Pregnancy alters immune responses and clinical manifestations of COVID-19, but its impact on Long COVID remains uncertain. This study investigated Long COVID risk in individuals with SARS-CoV-2 infection during pregnancy compared to reproductive-age females infected outside of pregnancy. A retrospective analysis of two U.S. databases, the National Patient-Centered Clinical Research Network (PCORnet) and the National COVID Cohort Collaborative (N3C), identified 29,975 pregnant individuals (aged 18–50) with SARS-CoV-2 infection in pregnancy from PCORnet and 42,176 from N3C between March 2020 and June 2023. At 180 days after infection, estimated Long COVID risks for those infected during pregnancy were 16.47 per 100 persons (95% CI, 16.00–16.95) in PCORnet using the PCORnet computational phenotype (CP) model and 4.37 per 100 persons (95% CI, 4.18–4.57) in N3C using the N3C CP model. Compared to matched non-pregnant individuals, the adjusted hazard ratios for Long COVID were 0.86 (95% CI, 0.83–0.90) in PCORnet and 0.70 (95% CI, 0.66–0.74) in N3C. The observed risk factors for Long COVID included Black race/ethnicity, advanced maternal age, first- and second-trimester infection, obesity, and comorbid conditions. While the findings suggest a high incidence of Long COVID among pregnant individuals, their risk was lower than that of matched non-pregnant females.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"103 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minerals will shape future geopolitical order","authors":"","doi":"10.1038/d41586-025-01006-1","DOIUrl":"https://doi.org/10.1038/d41586-025-01006-1","url":null,"abstract":"Letter to the Editor","PeriodicalId":18787,"journal":{"name":"Nature","volume":"15 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis","authors":"Gabriela Pessenda, Tiago R. Ferreira, Andrea Paun, Juraj Kabat, Eduardo P. Amaral, Olena Kamenyeva, Pedro Henrique Gazzinelli-Guimaraes, Shehan R. Perera, Sundar Ganesan, Sang Hun Lee, David L. Sacks","doi":"10.1038/s41467-025-58360-x","DOIUrl":"https://doi.org/10.1038/s41467-025-58360-x","url":null,"abstract":"<p>In murine models of visceral leishmaniasis (VL), the parasitization of resident Kupffer cells (resKCs) drives early <i>Leishmania infantum</i> growth in the liver, leading to granuloma formation and subsequent parasite control. Using the chronic VL model, we demonstrate that polyclonal resKCs redistributed to form granulomas outside the sinusoids, creating an open sinusoidal niche that was gradually repopulated by monocyte-derived KCs (moKCs) acquiring a tissue specific, homeostatic profile. Early-stage granulomas predominantly consisted of CLEC4F⁺KCs. In contrast, late-stage granulomas led to remodeling of the sinusoidal network and contained monocyte-derived macrophages (momacs) along with KCs that downregulated CLEC4F, with both populations expressing iNOS and pro-inflammatory chemokines. During late-stage infection, parasites were largely confined to CLEC4F^-KCs. Reduced monocyte recruitment and increased resKCs proliferation in infected <i>Ccr2</i>^−/− mice impaired parasite control. These findings show that the ontogenic heterogeneity of granuloma macrophages is closely linked to granuloma maturation and the development of hepatic immunity in VL.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"72 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis","authors":"Meritxell Oliva, Mrinal K. Sarkar, Michael E. March, Amir Hossein Saeidian, Frank D. Mentch, Chen-Lin Hsieh, Fanying Tang, Ranjitha Uppala, Matthew T. Patrick, Qinmengge Li, Rachael Bogle, J. Michelle Kahlenberg, Deborah Watson, Joseph T. Glessner, Leila Youssefian, Hassan Vahidnezhad, Lam C. Tsoi, Hakon Hakonarson, Johann E. Gudjonsson, Kathleen M. Smith, Bridget Riley-Gillis","doi":"10.1038/s41467-025-58310-7","DOIUrl":"https://doi.org/10.1038/s41467-025-58310-7","url":null,"abstract":"<p>Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to atopic dermatitis genetic association studies are poised to boost power to detect genetic signal and identify loci contributing to atopic dermatitis risk. Here, we present a multi-ancestry GWAS meta-analysis of twelve atopic dermatitis cohorts from five ancestral populations totaling 56,146 cases and 602,280 controls. We report 101 genomic loci associated with atopic dermatitis, including 16 loci that have not been previously associated with atopic dermatitis or eczema. Fine-mapping, QTL colocalization, and cell-type enrichment analyses identified genes and cell types implicated in atopic dermatitis pathophysiology. Functional analyses in keratinocytes provide evidence for genes that could play a role in atopic dermatitis through epidermal barrier function. Our study provides insights into the etiology of atopic dermatitis by harnessing multiple genetic and functional approaches to unveil the mechanisms by which atopic dermatitis-associated variants impact genes and cell types.</p>","PeriodicalId":19066,"journal":{"name":"Nature Communications","volume":"7 1","pages":""},"PeriodicalIF":16.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive insights into emerging advances in the Neurobiology of anorexia","authors":"Liwei Mao, Lian Wang, Zhihai Huang, Jian-Kang Chen, Lorelei Tucker, Quanguang Zhang","doi":"10.1016/j.jare.2025.03.046","DOIUrl":"https://doi.org/10.1016/j.jare.2025.03.046","url":null,"abstract":"<h3>Background</h3>Anorexia is a complex eating disorder influenced by genetic, environmental, psychological, and socio-cultural factors. Research into its molecular mechanisms and neural circuits has deepened our understanding of its pathogenesis. Recent advances in neuroscience, molecular biology, and genetics have revealed key molecular and neural circuit mechanisms underlying anorexia.Aim of reviewClarify the peripheral and central molecular mechanisms regulating various types of anorexia, identify key cytokines and neural circuits, and propose new strategies for its treatment.Key scientific concepts of reviewAnorexia animal models, including activity-induced, genetic mutation, and inflammation-induced types, are explored for their relevance to studying the disorder. Anorexic behavior is regulated by cytokines, hormones (like GDF15, GLP-1, and leptin), and neural circuits such as AgRP, serotonergic, dopaminergic, and glutamatergic pathways. Disruptions in these pathways, including GABAergic signaling in AgRP neurons and 5-HT2C and D2 receptors, contribute to anorexia. Potential therapies target neurotransmitter receptors, ghrelin receptors, and the GDF15-GFRAL pathway, offering insights for treating anorexia, immune responses, and obesity.","PeriodicalId":14952,"journal":{"name":"Journal of Advanced Research","volume":"1147 1","pages":""},"PeriodicalIF":10.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA-mediated regulation of ginsenoside biosynthesis in <i>Panax ginseng</i> and its biotechnological implications.","authors":"Seung Hee Eom, Tae Kyung Hyun","doi":"10.1177/00368504251332109","DOIUrl":"https://doi.org/10.1177/00368504251332109","url":null,"abstract":"<p><p><i>Panax ginseng</i>, renowned for its therapeutic properties, derives much of its medicinal value from ginsenosides, a group of bioactive triterpenoid saponins. The biosynthesis of ginsenosides is regulated by various mechanisms, including microRNAs (miRNAs), which play key roles in gene regulation. Recent studies have identified numerous miRNAs in <i>P</i>. <i>ginseng</i> and other plants, highlighting their potential to influence triterpenoid biosynthesis by targeting key genes in the pathway. This mini-review explores the current understanding of miRNA-mediated regulation in <i>P</i>. <i>ginseng</i> and discusses the potential for controlling ginsenoside production through miRNA manipulation. Although miRNA research in <i>P</i>. <i>ginseng</i> is still primitive, ongoing studies suggest its potential for promising applications in agriculture and medicine. Further functional studies on these miRNAs could provide valuable insights into optimizing ginsenoside biosynthesis and enhancing medicinal properties.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251332109"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A conserved ARF–DNA interface underlies auxin-triggered transcriptional response","authors":"Juriaan Rienstra, Vanessa Polet Carrillo-Carrasco, Martijn de Roij, Jorge Hernandez-Garcia, Dolf Weijers","doi":"10.1073/pnas.2501915122","DOIUrl":"https://doi.org/10.1073/pnas.2501915122","url":null,"abstract":"Auxin Response Factor (ARF) plant transcription factors are the key effectors in auxin signaling. Their DNA-Binding Domain (DBD) contains a B3 domain that allows base-specific interactions with Auxin Response Elements (AuxREs) in DNA target sites. Land plants encode three phylogenetically distinct ARF classes: the closely related A- and B-classes have overlapping DNA binding properties, contrasting with the different DNA-binding properties of the divergent C-class ARFs. ARF DNA-binding divergence likely occurred early in the evolution of the gene family, but the molecular determinants underlying it remain unclear. Here, we show that the B3 DNA-binding residues are deeply conserved in ARFs, and variability within these is only present in tracheophytes, correlating with greatly expanded ARF families. Using the liverwort <jats:italic>Marchantia polymorpha</jats:italic> , we confirm the essential role of conserved DNA-contacting residues for ARF function. We further show that ARF B3–AuxRE interfaces are not mutation-tolerant, suggesting low evolvability that has led to the conservation of the B3–DNA interface between ARF classes. Our data support the almost complete interchangeability between A/B-class ARF B3 by performing interspecies domain swaps in <jats:italic>M. polymorpha</jats:italic> , even between ARF lineages that diverged over half a billion years ago. Our analysis further suggests that C-class ARF DNA-binding specificity diverged early during ARF evolution in a common streptophyte ancestor, followed by strong selection in A and B-class ARFs as part of a competition-based auxin response system.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"5 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143757909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic suppression of quantum tunneling: Insights from Fefferman, Shapiro, and Weinstein.","authors":"Percy A Deift","doi":"10.1073/pnas.2503477122","DOIUrl":"https://doi.org/10.1073/pnas.2503477122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 13","pages":"e2503477122"},"PeriodicalIF":9.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of applying soft capping approach on earthen and masonry built heritage","authors":"Xinyu Jiang ,&nbsp;Sok Yee Yeo ,&nbsp;Barbara Galli","doi":"10.1016/j.culher.2025.03.007","DOIUrl":"10.1016/j.culher.2025.03.007","url":null,"abstract":"<div><div>Cultural heritage sites worldwide are increasingly threatened by deterioration due to natural erosion and the intensified effects of climate change. Soft capping, an environmentally friendly approach for protecting built heritage using plants, has been underexplored from a biological perspective. This article aims to review studies on soft capping applied to earthen and masonry heritage from the 1980s to the present. The findings categorise soft capping into four types: Phototropic biofilms- and Lichen-capping, Bryophyte-capping, Spermatophyte-capping and Mixed plants-capping. The selection of soft capping type depends on the site's microclimates, building materials and the structure's geometry. Soft capping helps to regulate the microclimates of affected structures, slowing deterioration and enhancing their long-term sustainability. Additionally, it offers flexible adaptation to individual cases for optimal protection. Despite the considerable benefits of soft capping, further research and expanded databases are necessary to better understand factors such as type selection, composition, protective efficacy and limitations. This knowledge will enable more informed conservation strategies for applying soft capping to heritage sites in the future.</div></div>","PeriodicalId":15480,"journal":{"name":"Journal of Cultural Heritage","volume":"73 ","pages":"Pages 158-171"},"PeriodicalIF":3.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet therapy for the management of obesity in children and adolescents: Overview of systematic reviews and meta-analysis of randomized controlled trials","authors":"Liubai Li, Jian Du, Feng Sun, Zhixia Li, Tianjiao Chen, Xuanyu Shi","doi":"10.1111/nyas.15307","DOIUrl":"https://doi.org/10.1111/nyas.15307","url":null,"abstract":"This overview of reviews analyzes the impact of diet therapy in the treatment of overweight and obesity in children and adolescents 0−19 years of age. A literature search was conducted in the Cochrane Library, Medline, EMBASE, and ClinicalTrials.gov. Systematic reviews and meta-analyses of randomized controlled trials in obesity treatment from June 2016 to November 2022 were retrieved. Obesity outcomes included body weight, body mass index (BMI), BMI z-score, among others. Twenty-three reviews on diet therapy and lifestyle interventions including diet were selected from 364 review records. Diet therapy showed limited effect on short-term obesity reduction. Moderate energy intake reduction (−500 kcal/day) with balanced diet was feasible and effective in obesity reduction in 6- to 18-year-olds, irrespective of macronutrient distribution. Very low-energy diet (≤800 kcal/day) should only be prescribed under strict monitoring. Diet as part of multicomponent lifestyle interventions may be beneficial in achieving small, short- to long-term reductions in body weight in children and adolescents across all age groups and settings. Obesity treatment in adolescents may improve self-esteem and health-related quality of life. Dietary strategies should focus on the reduction of total energy intake through the promotion of food-based initiatives/approaches guidance that target modification of usual eating patterns and behaviors.","PeriodicalId":8250,"journal":{"name":"Annals of the New York Academy of Sciences","volume":"38 1","pages":""},"PeriodicalIF":5.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143745352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}