IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-16 DOI: 10.1016/j.isci.2025.113578

Shuqiang Ren , Du Zhang , Xingwei Shi , Tianze Li , Qi Hu , Yance Feng , Chenghao Hu , Siting Feng , Yanna Zhu , Fei Gao

{"title":"Gut virome characteristics associated with early onset of anemia and neurodevelopmental delay in preterm infants","authors":"Shuqiang Ren , Du Zhang , Xingwei Shi , Tianze Li , Qi Hu , Yance Feng , Chenghao Hu , Siting Feng , Yanna Zhu , Fei Gao","doi":"10.1016/j.isci.2025.113578","DOIUrl":"10.1016/j.isci.2025.113578","url":null,"abstract":"<div><div>Early-onset anemia (EOA) and neurodevelopmental delay (NDD) are highly prevalent in preterm infants, causing substantial long-term health impacts. This study aimed to identify distinctive gut virome characteristics and their associations with EOA and NDD. We hypothesized that gut microbial colonization types and bacteriophage profiles may be risk factors for NDD in preterm infants with EOA. Fecal samples from 107 healthy preterm infants within the first week of life underwent virome and 16S rRNA sequencing. Consensus clustering of viral species signatures divided infants into four groups. The high EOA risk group showed significantly higher virome alpha diversity. Enriched <em>Circoviridae</em> sp. and <em>uncultured Caudoviridae phage</em>, along with reduced <em>CRESS virus</em> sp., were linked to elevated NDD risk. <em>Geobacillus virus Tp84</em>—the only bacteriophage exhibiting both temperate and virulent lifestyles—was associated with high EOA risk but low NDD risk. These findings highlight the role of gut virome in EOA and NDD pathogenesis, suggesting potential for targeted bacteriophage-based interventions to mitigate EOA-related NDD in preterm infants.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113578"},"PeriodicalIF":4.1,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ghrelin-GHSR-LEAP2 system in the pathophysiology of type 2 diabetes Ghrelin-GHSR-LEAP2系统在2型糖尿病病理生理中的作用

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-15 DOI: 10.1016/j.isci.2025.113573

Yueli Pu , Jianmei Yang , Wei Li , Yi Wen , Chunmei Zheng , Yonglin Li , Lijuan Wu , Yao Ming , Changying Zhao , Chen Chen

引用次数: 0

Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis 神经变性通过神经-免疫-癌症轴重新连接肿瘤微环境

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-15 DOI: 10.1016/j.isci.2025.113550

Jhommara Bautista , Emily C. Coral-Riofrio , Salomé Suárez Urresta , David Palacios-Zavala , Carolina E. Echeverría , Salomé Araujo-Abad , Andrés López-Cortés

{"title":"Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis","authors":"Jhommara Bautista , Emily C. Coral-Riofrio , Salomé Suárez Urresta , David Palacios-Zavala , Carolina E. Echeverría , Salomé Araujo-Abad , Andrés López-Cortés","doi":"10.1016/j.isci.2025.113550","DOIUrl":"10.1016/j.isci.2025.113550","url":null,"abstract":"<div><div>Neurodegeneration and cancer, long considered opposing processes, neuronal loss versus uncontrolled proliferation, are increasingly recognized as mechanistically convergent. This review reframes the field by positioning neurodegeneration as an active driver of tumor evolution. Integrating insights from multi-omics, spatial transcriptomics, and neuroimmune–microbiota studies, we show how degenerating neurons disrupt DNA repair, mitochondrial function, immune regulation, and barrier integrity, thereby creating tumor-permissive niches. Particular emphasis is placed on the enteric nervous system, where neuronal loss promotes colorectal and pancreatic cancers through immune suppression and microbial dysbiosis. Shared molecular regulators, including p53, Pin1, STING, and the Biglycan–IL-10–microbiota axis, exhibit dual roles, pro-apoptotic in neurons yet pro-survival in tumors, highlighting context-dependent biology. We propose a mechanistic, target-based therapeutic classification that transcends disease boundaries. Recognizing neurodegeneration as a tumor-promoting process uncovers novel diagnostic and therapeutic opportunities, expanding cancer neuroscience beyond its current paradigm.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113550"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Semiconductor manufacturing wastewater challenges and the potential solutions via printed electronics 半导体制造废水的挑战和通过印刷电子的潜在解决方案

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-15 DOI: 10.1016/j.isci.2025.113576

Sofia Sandhu , Ayoub Zumeit , Zhenyu Tian , Vincenzo Vinciguerra , Ravinder Dahiya

{"title":"Semiconductor manufacturing wastewater challenges and the potential solutions via printed electronics","authors":"Sofia Sandhu , Ayoub Zumeit , Zhenyu Tian , Vincenzo Vinciguerra , Ravinder Dahiya","doi":"10.1016/j.isci.2025.113576","DOIUrl":"10.1016/j.isci.2025.113576","url":null,"abstract":"<div><div>The rapid expansion of the semiconductor industry has not only accelerated global digital transformation but also brought serious environmental concerns, particularly through the discharge of hazardous, toxic, and persistent wastewater. Traditional semiconductor manufacturing is highly water and energy intensive, relying on critical and often toxic materials—many with proprietary or unknown chemical compositions. This review outlines the environmental impact of semiconductor wastewater, highlighting key contaminants and chemicals used in the process. Due to the complexity and sometimes the opacity of wastewater composition, current treatment technologies face significant limitations. The article also explores the potential for reducing environmental harm by transitioning toward minimal liquid discharge systems. In particular, it highlights alternative technologies such as printed electronics, which offer a promising path forward by minimizing the use of toxic chemicals, reducing energy consumption, and significantly lowering wastewater output. These strategies represent a realistic and necessary shift toward more sustainable semiconductor manufacturing practices.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113576"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Benefits and challenges of upcoming microbial plant protection applications sustaining planetary health 维持地球健康的微生物植物保护应用的益处和挑战

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-15 DOI: 10.1016/j.isci.2025.113557

Kalliope Κ. Papadopoulou , Antonis Chatzinotas , Belén Guijarro Diaz-Otero , Günter Brader , Dimitrios G. Karpouzas , Monica Garces Ruiz , José Luis Alonso Prados , Stéphane Declerck , Loukia M. Kellari , Angela Sessitsch

{"title":"Benefits and challenges of upcoming microbial plant protection applications sustaining planetary health","authors":"Kalliope Κ. Papadopoulou , Antonis Chatzinotas , Belén Guijarro Diaz-Otero , Günter Brader , Dimitrios G. Karpouzas , Monica Garces Ruiz , José Luis Alonso Prados , Stéphane Declerck , Loukia M. Kellari , Angela Sessitsch","doi":"10.1016/j.isci.2025.113557","DOIUrl":"10.1016/j.isci.2025.113557","url":null,"abstract":"<div><div>Plant disease outbreaks pose severe risks to global food security. Due to climate change, new diseases are expected to emerge, and the current use of chemical pesticides poses risks to environmental and human health. In the last decade, alternative plant protection agents of microbial origin have been developed, which also raise great expectations in the industry. Current products primarily represent individual microbial strains, either fungi or bacteria, which occasionally fail under field conditions due to various factors while their regulatory status differs globally. Recently, more diverse applications have started to emerge, ranging from microbial consortia, phages and protists to microbiome modulation or soil translocation. Integrated solutions, incorporating artificial intelligence are also proposed. In this review, we discuss the opportunities and challenges of these solutions, providing specific examples and discuss the regulatory needs for their market entry as well as their relevance for improving food security and planetary health.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113557"},"PeriodicalIF":4.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nonspecific ensemble reactivation in mouse dentate gyrus disrupts spatial working memory 小鼠齿状回非特异性集合再激活破坏空间工作记忆

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-15 DOI: 10.1016/j.isci.2025.113566

Lucius K. Wilmerding , Ivan Kondratyev , Wen Bing Shi , Steve Ramirez , Michael E. Hasselmo

引用次数: 0

Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable 少突胶质前体细胞AMPA受体随年龄和脑区不同而不同，而蓝酸盐受体保持稳定

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-13 DOI: 10.1016/j.isci.2025.113560

Yasmine Kamen , Kimberley Anne Evans , Yan Ting Ng (吳胤霆) , Sabine Dietmann , Ragnhildur Thóra Káradóttir

{"title":"Oligodendrocyte precursor cell AMPA receptors differ with age and brain region while kainate receptors remain stable","authors":"Yasmine Kamen , Kimberley Anne Evans , Yan Ting Ng (吳胤霆) , Sabine Dietmann , Ragnhildur Thóra Káradóttir","doi":"10.1016/j.isci.2025.113560","DOIUrl":"10.1016/j.isci.2025.113560","url":null,"abstract":"<div><div>Oligodendrocyte precursor cells (OPCs) proliferate and differentiate into myelinating oligodendrocytes throughout life. Many cues modulate OPC proliferation and differentiation, including neuronal activity, which OPCs sense through voltage-gated ion channels and glutamate receptors. However, OPCs display regional and temporal diversity in the membrane surface expression of these channels and receptors, altering their capacity to sense and respond to neuronal activity. Here, we use whole-cell patch-clamp in acute brain slices and bath-apply 3 μM kainate or 10 μM AMPA to investigate the heterogeneity in kainate and AMPA receptor membrane surface expression. We find that, while kainate receptor current density remains stable with age, OPCs do not respond to neuronal kainate receptor-specific drugs. In contrast, AMPA receptor current density differs with age and between regions, likely due to altered Ca<sup>2+</sup> permeability and receptor desensitization. The temporal changes in AMPA-evoked currents in OPCs correlate with reported age-related changes in proliferation and differentiation potential.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113560"},"PeriodicalIF":4.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding thermoelectric horizons: Establishing correlations between thermoelectric parameters and multifunctional sensing signals 扩大热电视野：建立热电参数与多功能传感信号之间的相关性

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-13 DOI: 10.1016/j.isci.2025.113549

Bangzhou Tian , Ran Ang

{"title":"Expanding thermoelectric horizons: Establishing correlations between thermoelectric parameters and multifunctional sensing signals","authors":"Bangzhou Tian , Ran Ang","doi":"10.1016/j.isci.2025.113549","DOIUrl":"10.1016/j.isci.2025.113549","url":null,"abstract":"<div><div>Thermoelectric (TE) materials have traditionally been explored for power generation and solid-state cooling. However, issues such as toxicity, limited conversion efficiency, poor long-term stability, and high cost continue to hinder their large-scale deployment. Recently, the intrinsic capability of TE materials to convert thermal stimuli into electrical signals has garnered increasing attention for multifunctional sensing applications, including tactile feedback, respiration monitoring, and remote thermal detection. TE-based sensors offer distinct advantages, such as fast response, high durability, and excellent signal reproducibility. In this perspective, we highlight three strategically important research directions to advance TE sensing: (1) investigating carrier dynamics during TE transduction, (2) correlating TE material performance with key sensing metrics via compositional and defect engineering, and (3) integrating materials design with machine learning-assisted optimization. Advancing these frontiers will lay the groundwork for next-generation TE sensors in the Internet of Things, personalized healthcare, and intelligent industrial monitoring.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113549"},"PeriodicalIF":4.1,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration Akt3磷酸化plectin促进三阴性乳腺癌细胞侵袭性迁移

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-12 DOI: 10.1016/j.isci.2025.113552

Shixue Zheng , Chloe Chan , John M. Asara , Liang Zhang , Gerhard Wiche , Y. Rebecca Chin

{"title":"Phosphorylation of plectin by Akt3 promotes triple-negative breast cancer cell invasive migration","authors":"Shixue Zheng , Chloe Chan , John M. Asara , Liang Zhang , Gerhard Wiche , Y. Rebecca Chin","doi":"10.1016/j.isci.2025.113552","DOIUrl":"10.1016/j.isci.2025.113552","url":null,"abstract":"<div><div>Triple-negative breast cancer (TNBC) lacks targeted therapeutics and is aggressive with a poor prognosis. The phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway, frequently deregulated in cancers, plays crucial roles in tumorigenesis and cancer progression. However, the distinct functions of the three Akt isoforms (Akt1, Akt2, Akt3) in these processes are not well understood. Here, we focus on Akt3, the least-studied Akt isoform, which is overexpressed in 28% of TNBC cases and significantly promotes TNBC growth, stemness, and epithelial-mesenchymal transition. Through a genome-wide proteomic screen, we identified plectin, a member of the plakin family, as an Akt3 substrate in TNBC cells. The depletion of plectin potently inhibits TNBC cell migration and invadopodia formation, albeit with mild effects on cell growth. The phosphorylation of plectin at Ser4268 by Akt promotes its colocalization with vimentin and TNBC cell migration. Our findings underscore the importance of Akt3-plectin signaling as a potential TNBC therapeutic target.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113552"},"PeriodicalIF":4.1,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Spike-Accum bioconjugate protein vaccine confers potent SARS-CoV-2-specific immunity 刺- accum生物偶联蛋白疫苗可提供有效的sars - cov -2特异性免疫

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-12 DOI: 10.1016/j.isci.2025.113457

Jean Pierre Bikorimana, Nathanael A. Caveney, Nehme EL-Hachem, Gabrielle A. Mandl, John A. Capobianco, Daniela Stanga, Jamilah Abusarah, Mark A. Hancock, Roudy Farah, Marina P. Gonçalves, Darryl Falzarano, Mingmin Liao, Glenn Hamonic, Qiang Liu, Simon Beaudoin, Sebastien Talbot, Moutih Rafei

引用次数: 0

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