iScience最新文献

Workshop report: Everyday environmental heritage is key to unlocking the social dimensions of One Health

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-18 DOI: 10.1016/j.isci.2025.112358

Marco J. Haenssgen , Tania Angeloff , Mark R. Herse , Elizabeth Auclair , Navaporn Sunanlikanon , Thipphaphone Xayavong , Jean-Marc Dubost , Somphavanh Radavanh , Chantho Vongnalath , Eric Deharo

引用次数: 0

JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-16 DOI: 10.1016/j.isci.2025.112438

Zhijie Zhang, Jiangzhou Shi, Qifang Wu, Zijian Zhang, Xiaoyan Liu, Anqi Ren, Guanlin Zhao, Ge Dong, Han Wu, Jiaxuan Zhao, Yuan Zhao, Jia Hu, Hui Li, Tongcun Zhang, Fuling Zhou, Haichuan Zhu

引用次数: 0

Activation of Hypoxia-Inducible Factor Signaling Modulates the RNA Protein Interactome in Caenorhabditis elegans

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-14 DOI: 10.1016/j.isci.2025.112411

Reza Esmaillie, Michael Ignarski, Katrin Bohl, Tim Krüger, Daniyal Ahmad, Lisa Seufert, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Francesca Fabretti

引用次数: 0

Placode and neural crest origins of congenital deafness in mouse models of Waardenburg-Shah syndrome

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-11 DOI: 10.1016/j.isci.2025.112400

Jaime Tan, Alicia Duron, Henry M. Sucov, Takako Makita

引用次数: 0

A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-08 DOI: 10.1016/j.isci.2025.112375

Côme Emmenecker , Jingqi Dai , Sandrine Lefranc , Ayoub Ouddah , Julie Guerin , Simine Pakzad , Philippe Andrey , Rajeev Kumar

{"title":"A high-throughput differential chemical genetic screen uncovers genotype-specific compounds altering plant growth","authors":"Côme Emmenecker , Jingqi Dai , Sandrine Lefranc , Ayoub Ouddah , Julie Guerin , Simine Pakzad , Philippe Andrey , Rajeev Kumar","doi":"10.1016/j.isci.2025.112375","DOIUrl":"10.1016/j.isci.2025.112375","url":null,"abstract":"<div><div>The identification of chemical compounds regulating plant growth in a genetic context can greatly enhance our understanding of biological mechanisms. Here, we have developed a high-throughput phenotype-directed chemical screening method in plants to compare two genotypes and identify small molecules inducing genotype-specific phenotypes. We used <em>Arabidopsis thaliana</em> wild type and <em>mus81</em>, a DNA repair mutant, and screened off-patent drugs from the Prestwick library to selectively identify molecules affecting <em>mus81</em> growth. We developed two complementary convolutional neural networks (CNN)-based image segmentation and classification programs to quantify <em>Arabidopsis</em> seedling growth. Using these approaches, we detected that about 10% of Prestwick molecules cause altered growth in both genotypes, suggesting their toxic effects on plant growth. We identified three Prestwick molecules specifically affecting <em>mus81</em>. Overall, we developed a straightforward, accurate, and adaptable methodology for performing high-throughput screening of chemical libraries in a time-efficient manner, accelerating the discovery of genotype-specific chemical regulators of plant growth.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112375"},"PeriodicalIF":4.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-08 DOI: 10.1016/j.isci.2025.112379

Qinyao Li , Ting Zhang , Zhichao Li , Xiao Qi , Xinyue Mei , Sheng Liu , Siyu He , Gan Qiao , Rong Li , Hongping Shen , Jing Zeng , Feihong Huang , Shuang Dai , Sirui Li , Jiesi Luo , Jianming Wu , Long Wang

{"title":"Targeting CCR5 with miltefosine as a therapeutic strategy for thrombocytopenia","authors":"Qinyao Li , Ting Zhang , Zhichao Li , Xiao Qi , Xinyue Mei , Sheng Liu , Siyu He , Gan Qiao , Rong Li , Hongping Shen , Jing Zeng , Feihong Huang , Shuang Dai , Sirui Li , Jiesi Luo , Jianming Wu , Long Wang","doi":"10.1016/j.isci.2025.112379","DOIUrl":"10.1016/j.isci.2025.112379","url":null,"abstract":"<div><div>Thrombocytopenia remains a challenging clinical condition with limited treatment options. Here, we demonstrated that miltefosine stimulated megakaryocyte (MK) differentiation <em>in vitro</em>. Miltefosine significantly accelerated platelet recovery, enhanced platelet function, and boosted MK production and differentiation in irradiated mice. RNA sequencing revealed association of CCR5, MAPK, and JAK2/STAT3 signaling pathways in miltefosine-mediated MK differentiation. Molecular docking, drug affinity responsive target stability (DARTS), and surface plasmon resonance (SPR) assays confirmed direct binding of miltefosine to CCR5. Inhibition of CCR5 disrupted miltefosine’s effects on MK differentiation and activation of MAPK and JAK2/STAT3 signaling pathways, as well as key transcription factors GATA1, EGR1, and TAL1. Similarly, blockade of the MAPK or JAK2/STAT3 signaling pathways hindered miltefosine-induced MK differentiation and transcription factor activation. Our findings establish CCR5 as a therapeutic target for thrombocytopenia and identify miltefosine as a CCR5 agonist that promotes MK differentiation and platelet production via MAPK and JAK2/STAT3 signaling.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112379"},"PeriodicalIF":4.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flex multimode neural network for complete optical computation

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-08 DOI: 10.1016/j.isci.2025.112376

Zeyu Deng , Zhangqi Dang , Ziyang Zhang

引用次数: 0

Flexible, large area preparable phase change PVA/P(ILs-AM)/SSD films for electromagnetic wave absorption and infrared stealth

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112366

Yi Liang , Lechun Deng , Bingcheng Luo , Limin Zhang , Kai Tao , Xuexiang Li , Qiang Chen , Hongjing Wu

{"title":"Flexible, large area preparable phase change PVA/P(ILs-AM)/SSD films for electromagnetic wave absorption and infrared stealth","authors":"Yi Liang , Lechun Deng , Bingcheng Luo , Limin Zhang , Kai Tao , Xuexiang Li , Qiang Chen , Hongjing Wu","doi":"10.1016/j.isci.2025.112366","DOIUrl":"10.1016/j.isci.2025.112366","url":null,"abstract":"<div><div>Electromagnetic wave absorption (EMA) and infrared stealth are two vital ways of anti-detection that it is a great challenge to develop a compatible material which is low-cost, easy to prepare and exhibits excellent mechanical properties. Here, multifunctional films are prepared using one-pot method by wrapping phase change crystals Na<sub>2</sub>SO<sub>4</sub>·10H<sub>2</sub>O (SSD) with dual-network molecular chains. The phase change behavior with high enthalpy (150.8 J/g) at a temperature of 31.2°C can absorb and release latent heat, which endows films with the ability to regulate temperature dynamically. The dual-network acts as phase change buffer-medium to prevent leakage, with excellent mechanical properties, and also provides abundant conductivity and polarization loss. The results show that the films significantly reduce thermal radiation temperature of the target in low-medium temperatures while achieving excellent EMA properties (the effective absorption bandwidth reaches 6 GHz at 1.9 mm). It provides an idea for the development of multi-band compatible functional materials.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112366"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112364

Marc Nater , Michael Brügger , Virginia Cecconi , Paulo Pereira , Geo Forni , Hakan Köksal , Despoina Dimakou , Michael Herbst , Anna Laura Calvanese , Giulia Lucchiari , Christoph Schneider , Tomas Valenta , Maries van den Broek

{"title":"Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver","authors":"Marc Nater , Michael Brügger , Virginia Cecconi , Paulo Pereira , Geo Forni , Hakan Köksal , Despoina Dimakou , Michael Herbst , Anna Laura Calvanese , Giulia Lucchiari , Christoph Schneider , Tomas Valenta , Maries van den Broek","doi":"10.1016/j.isci.2025.112364","DOIUrl":"10.1016/j.isci.2025.112364","url":null,"abstract":"<div><div>The liver is an important metastatic organ that contains many innate immune cells, yet little is known about their role in anti-metastatic defense. We investigated how invariant natural killer T (iNKT) cells influence colorectal cancer-derived liver metastasis using different models in immunocompetent mice. We found that hepatic iNKT cells promote metastasis by creating a supportive niche for disseminated cancer cells. Mechanistically, iNKT cells respond to disseminating cancer cells by producing the fibrogenic cytokines interleukin-4 (IL-4) and IL-13 in a T cell receptor-independent manner. Selective abrogation of IL-4 and IL-13 sensing in hepatic stellate cells prevented their transdifferentiation into extracellular matrix-producing myofibroblasts, which hindered metastatic outgrowth of disseminated cancer cells. This study highlights a novel tumor-promoting axis driven by iNKT cells in the initial stages of metastasis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112364"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participatory science in urban soil research: A framework for overcoming challenges and expanding public engagement

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112361

Anna A. Paltseva

{"title":"Participatory science in urban soil research: A framework for overcoming challenges and expanding public engagement","authors":"Anna A. Paltseva","doi":"10.1016/j.isci.2025.112361","DOIUrl":"10.1016/j.isci.2025.112361","url":null,"abstract":"<div><div>Urban soils play a crucial role in supporting city sustainability, including green infrastructure, food production, water regulation, and climate resilience. Yet their complexity, compounded by environmental risks, pose challenges for research and policy. This article presents a participatory science framework that engages communities in soil monitoring and management through co-designed projects, educational outreach, and simplified data collection protocols. By integrating digital tools and real-time mapping, the framework enhances data accuracy while fostering environmental stewardship. Grounded in interdisciplinary collaboration, the framework connects scientific research, technological support, community engagement, and policy advocacy to improve urban soil health. Demonstrated through case studies and practical strategies, this approach builds capacity for sustained community involvement and equitable environmental decision-making. The broader significance lies in the framework’s ability to foster reciprocal relationships between scientists and communities, where shared knowledge, action, and responsibility strengthen urban soil stewardship.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112361"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0