IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-19 DOI: 10.1016/j.isci.2025.112216

Qian Xia, Meng Mao, Gaofeng Zhan, Zhenzhao Luo, Yin Zhao, Xing Li

引用次数: 0

Retraction Notice to: c-JUN inhibits mTORC2 and glucose uptake to promote self-renewal and obesity

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-19 DOI: 10.1016/j.isci.2025.112231

Raphael Serna, Ambika Ramrakhiani, Juan Carlos Hernandez, Chia-Lin Chen, Chad Nakagawa, Tatsuya Machida, Ratna B. Ray, Xiaohang Zhan, Stanley M. Tahara, Keigo Machida

引用次数: 0

Empowering through mentorship: The journey of women in interdisciplinary science

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-13 DOI: 10.1016/j.isci.2025.111865

Uttama Mukherjee , Ramya Kormath Madam Raghupathy , Minal Sachin Pednekar , Sradha Jayan

{"title":"Empowering through mentorship: The journey of women in interdisciplinary science","authors":"Uttama Mukherjee , Ramya Kormath Madam Raghupathy , Minal Sachin Pednekar , Sradha Jayan","doi":"10.1016/j.isci.2025.111865","DOIUrl":"10.1016/j.isci.2025.111865","url":null,"abstract":"<div><div>In this backstory, we feature four remarkable women in science who have collaborated with Prof. Arun Venkatnathan (referred to in this piece as Prof. Arun) from Indian Institute of Science Education and Research (IISER)-Pune at various stages of their careers and reflect on the importance of mentorship to foster interdisciplinary thinking. In his career, Prof. Arun has advocated for the importance of gender diversity and women empowerment and has incorporated this work into the development of his research program. This piece highlights the pivotal role of skilled mentorship as the cornerstone of a successful scientific career. The interview delves into how mentorship is essential in building scientists’ confidence and fostering an environment of mutual respect. This supportive atmosphere encourages collaboration and interdisciplinary thinking, helping researchers navigate the challenges of cross-disciplinary communication and acquire new skills. Ultimately, success in interdisciplinary research demands motivation, continuous learning, unwavering passion, and encouragement.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111865"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the uncertainty principle of neural networks

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-10 DOI: 10.1016/j.isci.2025.112197

Jun-Jie Zhang , Dong-Xiao Zhang , Jian-Nan Chen , Long-Gang Pang , Deyu Meng

{"title":"On the uncertainty principle of neural networks","authors":"Jun-Jie Zhang , Dong-Xiao Zhang , Jian-Nan Chen , Long-Gang Pang , Deyu Meng","doi":"10.1016/j.isci.2025.112197","DOIUrl":"10.1016/j.isci.2025.112197","url":null,"abstract":"<div><div>In this study, we explore the inherent trade-off between accuracy and robustness in neural networks, drawing an analogy to the uncertainty principle in quantum mechanics. We propose that neural networks are subject to an uncertainty relation, which manifests as a fundamental limitation in their ability to simultaneously achieve high accuracy and robustness against adversarial attacks. Through mathematical proofs and empirical evidence, we demonstrate that this trade-off is a natural consequence of the sharp boundaries formed between different class concepts during training. Our findings reveal that the complementarity principle, a cornerstone of quantum physics, applies to neural networks, imposing fundamental limits on their capabilities in simultaneous learning of conjugate features. Meanwhile, our work suggests that achieving human-level intelligence through a single-network architecture or massive datasets alone may be inherently limited. Our work provides new insights into the theoretical foundations of neural network vulnerability and opens up avenues for designing more robust neural network architectures.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112197"},"PeriodicalIF":4.6,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143609138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-07 DOI: 10.1016/j.isci.2025.112182

Jingru Zhuang (庄静茹) , Ying Ren (任颖) , Minmin Chen (陈敏敏) , Minghui Yue (岳明辉) , Changyong Yuan (袁长永) , Rongquan Duan (段荣泉)

{"title":"Efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes: A systematic review and meta-analysis","authors":"Jingru Zhuang (庄静茹) , Ying Ren (任颖) , Minmin Chen (陈敏敏) , Minghui Yue (岳明辉) , Changyong Yuan (袁长永) , Rongquan Duan (段荣泉)","doi":"10.1016/j.isci.2025.112182","DOIUrl":"10.1016/j.isci.2025.112182","url":null,"abstract":"<div><div>Our meta-analysis aimed to evaluate the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes. PubMed, Cochrane Library, Embase, and Web of Science were comprehensively searched until 4 December 2024, and 10 randomized controlled trials (RCTs) were included. The results indicated that, compared to the control group, localized sustained-release drugs significantly reduced probing depth (PD) (SMD = −0.77, 95% confidence interval [CI] (−1.37, −0.16)) but did not reduce clinical attachment loss (CAL) (SMD = −0.18, 95% CI (−0.60, 0.23)), sites with glycated hemoglobin (HbA1c) (SMD = 0.03, 95% CI (−0.38, 0.43)), plaque index (SMD = −0.37, 95% CI (−0.80, 0.06)), sites with bleeding on probing (BOP) (SMD = −0.26, 95% CI (−0.68, 0.16)), and gingival index (SMD = 0.07, 95% CI (−0.30, 0.44)). Subgroup analysis by different drugs elicited that, compared to the control treatment, chlorhexidine was effective in reducing BOP% (SMD = −0.55, 95% CI (−0.90, −0.19)). Our meta-analysis finds that the efficacy of localized sustained-release drugs in periodontitis and comorbid diabetes is limited.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112182"},"PeriodicalIF":4.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polarization-insensitive narrowband reflective wavefront manipulation through all-dielectric anisotropic subwavelength structures

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-07 DOI: 10.1016/j.isci.2025.112147

Meiyan Pan , Yanxin Lu , Jintao Wang , Yihang Chen

{"title":"Polarization-insensitive narrowband reflective wavefront manipulation through all-dielectric anisotropic subwavelength structures","authors":"Meiyan Pan , Yanxin Lu , Jintao Wang , Yihang Chen","doi":"10.1016/j.isci.2025.112147","DOIUrl":"10.1016/j.isci.2025.112147","url":null,"abstract":"<div><div>Local metasurfaces provide high flexibility in shaping wavefronts but suffer from poor frequency selectivity. Here, we numerically present a reflective all-dielectric metasurface platform achieving simultaneous local phase control and spectral filtering: it reshapes the wavefront at a specific wavelength while spatially separating it from other wavelengths without requiring additional optics. The highly efficient phase control is inherently linked to the high polarization conversion ratio (PCR), ensured by a silicon nanoblock as a narrowband reflective half-wave plate through fundamental Mie resonances. The meta-atom exhibits near-unity peak reflection, a PCR reaching 0.97, and a quality factor around 20. By adjusting rotation angles, we disrupt the geometric phase conjugation, enabling polarization-insensitive applications, for example, a metalens with a high relative focusing efficiency (0.7) across the narrowband reflective spectrum. Our design exhibits high robustness against variations in the angle of incidence (up to 28<sup>°</sup>) and fabrication inaccuracies, allowing its implementation in various meta-applications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112147"},"PeriodicalIF":4.6,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global potential of continuous sorption-based atmospheric water harvesting

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-05 DOI: 10.1016/j.isci.2025.112160

Wenjun Ying , Chunfeng Li , Liang Yang , Lingji Hua , Hua Zhang , Ruzhu Wang , Jiayun Wang

{"title":"Global potential of continuous sorption-based atmospheric water harvesting","authors":"Wenjun Ying , Chunfeng Li , Liang Yang , Lingji Hua , Hua Zhang , Ruzhu Wang , Jiayun Wang","doi":"10.1016/j.isci.2025.112160","DOIUrl":"10.1016/j.isci.2025.112160","url":null,"abstract":"<div><div>Sorption-based atmospheric water harvesting (SAWH) offers a decentralized solution for freshwater generation in remote and arid regions. Continuous SAWH systems, with their compact design and energy efficiency, present advantages over discontinuous systems for kilogram-scale water supply. Using global meteorological data and advanced modeling, we evaluated the performance of passive and active continuous systems, incorporating the isothermal and dynamic properties of twelve advanced sorbents, such as hydrogels, metal-organic frameworks, and composites. Results show that solar-powered continuous SAWH systems can operate effectively year-round in 39.53% of global districts, while active systems enable low-energy harvesting in 55.27% of districts. Temperature and humidity significantly influence performance, with correlations of 47.41% and 86.41%, respectively, surpassing the impact of atmospheric pressure and solar radiation. This study provides a predictive framework for global SAWH performance, offering design insights to optimize system efficiency and guide sorbent development for broader applications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112160"},"PeriodicalIF":4.6,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of self-care tooling and phylogenetic modeling reveal parrot tool use is not rare

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-04 DOI: 10.1016/j.isci.2025.112156

Amalia P.M. Bastos , Scott Claessens , Ximena J. Nelson , David Welch , Quentin D. Atkinson , Alex H. Taylor

引用次数: 0

Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types 肠道微生物组中丰富的通路可预测不同人口统计学区域和不同癌症类型对免疫检查点抑制剂治疗的反应

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-04 DOI: 10.1016/j.isci.2025.112162

Xunhui Cai , Jennifer Y. Cho , Lijun Chen , Yufeng Liu , Fenghu Ji , Katia Salgado , Siyi Ge , Dehua Yang , Hui Yu , Jianbo Shao , P. Andrew Futreal , Boris Sepesi , Don Gibbons , Yaobing Chen , Guoping Wang , Chao Cheng , Meng Wu , Jianjun Zhang , Ansel Hsiao , Tian Xia

{"title":"Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types","authors":"Xunhui Cai , Jennifer Y. Cho , Lijun Chen , Yufeng Liu , Fenghu Ji , Katia Salgado , Siyi Ge , Dehua Yang , Hui Yu , Jianbo Shao , P. Andrew Futreal , Boris Sepesi , Don Gibbons , Yaobing Chen , Guoping Wang , Chao Cheng , Meng Wu , Jianjun Zhang , Ansel Hsiao , Tian Xia","doi":"10.1016/j.isci.2025.112162","DOIUrl":"10.1016/j.isci.2025.112162","url":null,"abstract":"<div><div>Understanding the effect of gut microbiota function on immune checkpoint inhibitor (ICI) responses is urgently needed. Here, we integrated 821 fecal metagenomes from 12 datasets to identify differentially abundant genes and construct random forest models to predict ICI response. Gene markers demonstrated excellent predictive performance, with an average area under the curve (AUC) of 0.810. Pathway analyses revealed that quorum sensing (QS), ABC transporters, flagellar assembly, and amino acid biosynthesis pathways were enriched between responders (R) and non-responders (NRs) across 12 datasets. Furthermore, <em>luxS</em>, <em>manA</em>, <em>fliC</em>, and <em>trpB</em> exhibited consistent changes between R and NR across 12 datasets. Follow-up microbiota transplant experiments showed that inter-species signaling by different QS autoinducer-2 (AI-2) molecules (synthesized by <em>luxS</em>) can act on overall community function to promote the colonization of <em>Akkermansia muciniphila</em>, which is associated with superior ICI responses. Together, our data highlight the role of gut microbiota function in modulating the microbiome and antitumor immunity.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112162"},"PeriodicalIF":4.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elastic properties of leukemic cells linked to maturation stage and integrin activation

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-04 DOI: 10.1016/j.isci.2025.112150

Ceri J. Richards , Albertus T.J. Wierenga , Annet Z. Brouwers-Vos , Emmanouil Kyrloglou , Laura S. Dillingh , Patty P.M.F.A. Mulder , Georgios Palasantzas , Jan Jacob Schuringa , Wouter H. Roos

{"title":"Elastic properties of leukemic cells linked to maturation stage and integrin activation","authors":"Ceri J. Richards , Albertus T.J. Wierenga , Annet Z. Brouwers-Vos , Emmanouil Kyrloglou , Laura S. Dillingh , Patty P.M.F.A. Mulder , Georgios Palasantzas , Jan Jacob Schuringa , Wouter H. Roos","doi":"10.1016/j.isci.2025.112150","DOIUrl":"10.1016/j.isci.2025.112150","url":null,"abstract":"<div><div>Acute myeloid leukemia (AML) remains challenging to cure. In addition to mutations that alter cell functioning, biophysical properties are modulated by external cues. In particular, membrane proteins that interact with the bone marrow niche can induce cellular changes. Here, we develop an atomic force microscopy (AFM) approach to measure non-adherent AML cell mechanical properties. The Young’s modulus of the AML cell line, THP-1, increased in response to retronectin, whereas knock-out of the adhesion protein <em>ITGB1</em> resulted in no response to retronectin. Confocal microscopy revealed different actin cytoskeleton morphologies for wild-type and <em>ITGB1</em> knock-out cells exposed to retronectin. These results indicate that <em>ITGB1</em> mediates stimuli-induced cellular mechanoresponses through cytoskeletal changes. We next used AFM to investigate the elastic properties of primary AML cells and found that more committed cells had lower Young’s moduli than immature AMLs. Overall, this provides a platform for investigating the molecular mechanisms involved in leukemic cell mechanoresponse.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112150"},"PeriodicalIF":4.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143654788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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