iScience最新文献_第2页

Urban habitats offer buffered environmental conditions for city-dwelling bats. 城市栖息地为城市栖息的蝙蝠提供了缓冲的环境条件。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-02 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117767

Jianan Ding, Arjan Boonman, Ofri Eitan, Yuval Werber, David Troupin, Nir Sapir, Yossi Yovel

引用次数: 0

An ultrasound-switchable hydrogel enables sequential antibacterial and anti-inflammatory therapy for infected diabetic wounds. 超声可切换水凝胶使顺序抗菌和抗炎治疗感染糖尿病伤口。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117711

Jiahua Zhu, Chi Zhang, Qian Zhang, Fansen Xu, Baojie Wen, Ye Xu, Sen Wang

{"title":"An ultrasound-switchable hydrogel enables sequential antibacterial and anti-inflammatory therapy for infected diabetic wounds.","authors":"Jiahua Zhu, Chi Zhang, Qian Zhang, Fansen Xu, Baojie Wen, Ye Xu, Sen Wang","doi":"10.1016/j.isci.2026.117711","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117711","url":null,"abstract":"Traditional dressings often fail to address the dynamic progression of infected diabetic wounds, which requires early bacterial elimination followed by timely control of oxidative stress and inflammation. Here, we developed an ultrasound-switchable Ce6/celastrol hydrogel for sequential antibacterial and anti-inflammatory therapy. Chlorin e6 (Ce6) and celastrol were co-encapsulated in a gelatin methacrylate (GelMA) hydrogel. Upon ultrasound irradiation, Ce6 generated singlet oxygen to reduce methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli (E. coli) in vitro. After ultrasound cessation, celastrol scavenged residual reactive oxygen species and suppressed inflammation. In an MRSA-infected diabetic wound model, the hydrogel with ultrasound reduced bacterial burden, alleviated inflammation, promoted collagen deposition, and accelerated wound closure. This strategy provides temporally regulated antibacterial and anti-inflammatory therapy for infected diabetic wounds.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117711"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657357/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroid plexus remodeling associated with inflammatory CSF exposure in preterm acquired hydrocephalus. 早产儿获得性脑积水中脉络丛重构与炎性脑脊液暴露相关。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117759

Gio Jison, Noah Ramos, Fernando Cotrim-Gomes, Seunghyun Lee, Brian W Hanak, Michael Muhonen, Leandro Castañeyra-Ruiz

{"title":"Choroid plexus remodeling associated with inflammatory CSF exposure in preterm acquired hydrocephalus.","authors":"Gio Jison, Noah Ramos, Fernando Cotrim-Gomes, Seunghyun Lee, Brian W Hanak, Michael Muhonen, Leandro Castañeyra-Ruiz","doi":"10.1016/j.isci.2026.117759","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117759","url":null,"abstract":"Acquired hydrocephalus in preterm infants follows intraventricular hemorrhage (IVH) or central nervous system infection and is associated with inflammatory cerebrospinal fluid (CSF) profiles. We integrated clinical magnetic resonance imaging (MRI), CSF cytokine profiling, primary human choroid plexus (ChP) epithelial and endothelial cell assays, and independent transcriptomic and proteomic datasets to investigate ChP remodeling. Infants requiring CSF diversion exhibited greater ChP thickness independent of gestational age, ventricular size, and IVH severity, supporting its potential as a biomarker. Growth factor-enriched inflammatory CSF increased proliferation in primary human ChP epithelial and endothelial cells; EGFR and VEGFR inhibition attenuated these responses, and recombinant epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) reproduced proliferative effects. Independent IVH transcriptomic data confirmed Mki67 elevation in IVH ChP tissue. Integrated proteomic trajectories support a temporally dynamic remodeling framework linking acute inflammatory signaling to proliferative ChP activation and structural remodeling.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117759"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast. 抗真菌肽茶胞酰胺A通过细胞膜扰动引起细胞壁葡聚糖异位过量生产。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117645

Kensuke Nakao, Vanessa S D Carvalho, Akifumi Suganaga, Masako Osumi, Masato Tokukura, Hideaki Kakeya, Akihisa Matsuyama, Yoko Yashiroda, Shigeki Matsunaga, Juan C G Cortés, Minoru Yoshida, Juan C Ribas, Shinichi Nishimura

{"title":"Ectopic overproduction of cell wall glucan through membrane perturbation by an antifungal peptide theonellamide A in fission yeast.","authors":"Kensuke Nakao, Vanessa S D Carvalho, Akifumi Suganaga, Masako Osumi, Masato Tokukura, Hideaki Kakeya, Akihisa Matsuyama, Yoko Yashiroda, Shigeki Matsunaga, Juan C G Cortés, Minoru Yoshida, Juan C Ribas, Shinichi Nishimura","doi":"10.1016/j.isci.2026.117645","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117645","url":null,"abstract":"Ergosterol has multiple functions in filamentous fungi and yeasts, although only a part of the functions seems to be understood. An antifungal peptide, theonellamide A (TNM-A) induces drastic morphological changes in fission yeast by targeting plasma membrane ergosterol. TNM-A induces overproduction and accumulation of cell wall glucan at growing tips and septum through a yet unknown mechanism. Here, we show that TNM-A causes accumulation of 1,3-β-glucan at cell-polarity sites, not by increased activity of 1,3-β-glucan synthase, but by an increased, persistent localization of the glucan synthases. Screening based on subcellular localization of proteins suggested the involvement of the Rho family GTPase Cdc42, a master regulator of cell polarity. In agreement, TNM-A increased active Cdc42 and enhanced the membrane trafficking of glucan synthases. In conclusion, our chemical genetics analyses using TNM-A suggest that membrane ergosterol regulates the Cdc42 activity, which further regulates the localization of glucan synthases and cell wall biosynthesis.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117645"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trait anxiety selectively amplifies reward learning under uncertainty, while N3 sleep attenuates it. 特质焦虑选择性地放大了不确定性下的奖励学习，而N3睡眠则减弱了它。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117745

Rakshita Deshmukh, Arjun Ramakrishnan

{"title":"Trait anxiety selectively amplifies reward learning under uncertainty, while N3 sleep attenuates it.","authors":"Rakshita Deshmukh, Arjun Ramakrishnan","doi":"10.1016/j.isci.2026.117745","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117745","url":null,"abstract":"Adaptive learning under uncertainty requires distinguishing random variability (stochasticity) from true environmental change (volatility), yet how trait anxiety and sleep together influence it remains unclear. Across two preregistered experiments, participants completed a probabilistic reversal-learning task that independently manipulated volatility and stochasticity. Hierarchical Bayesian modeling showed that in stable but noisy environments, individuals with higher trait anxiety appeared to treat stochastic fluctuations as indicators of genuine change, resulting in over updating and lower evidence accumulation, while preserving normative trends in volatile environments. In a second experiment combining task performance with overnight sleep electroencephalography, greater N3 sleep was associated with reduced updating and higher evidence accumulation in stable environments among individuals with higher trait anxiety. These findings suggest that trait anxiety selectively alters how uncertainty is computationally represented, while N3 sleep appears to attenuate it. Together, these findings provide a computational framework linking anxiety, sleep, and adaptive learning under uncertainty.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117745"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genomic structural variations distinguishing archaic and modern humans are associated with neurodevelopment. 区分古人类和现代人的基因组结构变异与神经发育有关。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117741

Shiyu Zha, Cheng Li, Chao Zhang

引用次数: 0

An unexploited almond biodiversity in central Italy: Genetic characterization and conservation strategies using molecular markers. 意大利中部未开发的杏仁生物多样性：利用分子标记的遗传特征和保护策略。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.116502

Michele Antonio Savoia, Natalia Sgaramella, Ambra Micheletti, Paola Staffolani, Liliana Gaeta, Pasquale Venerito, Monica Marilena Miazzi, Valentina Fanelli, Cinzia Montemurro

{"title":"An unexploited almond biodiversity in central Italy: Genetic characterization and conservation strategies using molecular markers.","authors":"Michele Antonio Savoia, Natalia Sgaramella, Ambra Micheletti, Paola Staffolani, Liliana Gaeta, Pasquale Venerito, Monica Marilena Miazzi, Valentina Fanelli, Cinzia Montemurro","doi":"10.1016/j.isci.2026.116502","DOIUrl":"https://doi.org/10.1016/j.isci.2026.116502","url":null,"abstract":"Almond is one of the most important nut crops worldwide. In Italy, 96% of the national almond production is covered by the Southern regions. However, small resources of cultivated and wild trees are also found in central Italian regions like Abruzzo, Sardinia, and Marche. Exploratory missions throughout the Marche region revealed the presence of many local and uncharacterized almond genotypes. The aim of this study was to recover this germplasm and characterize it using molecular markers. The genetic analysis revealed a high genetic variation in Marche almond genotypes, which showed them to be genetically distinct from the Italian and international varieties. A great richness in private alleles was found in the Marche almond collection, supporting the uniqueness of this germplasm and the importance of this resource of genetic diversity for the development of conservation programs and the implementation of almond breeding activities.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"116502"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus recommendations for neurofibromatosis type 1 management in Asia Pacific. 亚太地区1型神经纤维瘤病治疗的共识建议。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117002

Yemima Berman, Beom Hee Lee, Anthony Pak-Yin Liu, Yoshihiro Nishida, Ee Shien Tan, Zhichao Wang

引用次数: 0

Decoding how RNase E membrane targeting controls RNA degradosome activity in Pseudomonas aeruginosa. 破解RNase E膜靶向控制铜绿假单胞菌RNA降解体活性的机制。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117717

Sandra Amandine Marie Geslain, George Edward Allen, Johan Geiser, Peter Redder, Martina Valentini

{"title":"Decoding how RNase E membrane targeting controls RNA degradosome activity in Pseudomonas aeruginosa.","authors":"Sandra Amandine Marie Geslain, George Edward Allen, Johan Geiser, Peter Redder, Martina Valentini","doi":"10.1016/j.isci.2026.117717","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117717","url":null,"abstract":"In many Proteobacterial species, transcription and RNA degradation are physically separated through segregation of the main ribonucleolytic machinery-the RNA degradosome-into RNase E-driven membrane-anchored assemblies that form discrete foci. Despite widespread conservation of the amphipathic membrane-targeting sequence (MTS) in RNase E, its function and biological importance remain poorly understood. Here, we have investigated how the MTS contributes to bacterial virulence or stress response in Pseudomonas aeruginosa. We show that membrane anchoring is dispensable for formation of RNA degradosome foci, but required for their proper morphology, dynamics, and localization, whereas the MTS sequence modulates foci behavior. Transcriptomic and mRNA spatial organization analyses further reveal specific stabilization of localized transcripts encoding membrane proteins in the MTS mutant, together with abnormal operon processing. Altogether, our study reveals the elegant MTS-mediated control of RNA degradosome spatial organization and target selection, shaping the transcriptome and bacterial stress responses.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117717"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline techno-economic and life cycle assessment of black mass production. 黑量产的基线技术经济和生命周期评价。

IF 4.5 2区综合性期刊

iScience Pub Date : 2026-10-01 eCollection Date: 2026-10-16 DOI: 10.1016/j.isci.2026.117729

Tanongsak Yingnakorn, Chatisa Kansomket, Chaiyasit Longbutsri, Sean Scott, Tapany Patcharawit, Jake M Yang, Andrew P Abbott, Sakhob Khumkoa

{"title":"Baseline techno-economic and life cycle assessment of black mass production.","authors":"Tanongsak Yingnakorn, Chatisa Kansomket, Chaiyasit Longbutsri, Sean Scott, Tapany Patcharawit, Jake M Yang, Andrew P Abbott, Sakhob Khumkoa","doi":"10.1016/j.isci.2026.117729","DOIUrl":"https://doi.org/10.1016/j.isci.2026.117729","url":null,"abstract":"Recycling lithium-ion batteries hinges on economically producing black mass-the electrode powder concentrate that feeds downstream metal recovery-yet public baselines pairing real process economics with environmental impacts remain scarce. Here we show that a purely mechanical flowsheet-shredding, zigzag air classification, and circular screen vibration-applied identically to two structurally distinct feedstocks recovers black mass at 93.28 wt % separation efficiency from electric-vehicle modules and 75.77 wt % from mobile phone cells. Built on measured pilot data, loaded processing costs of $0.31-0.73/kg yield net profits of $4.39-5.53/kg under realistic feedstock purchase prices, with a probability of unprofitability below 0.2% across simulated market scenarios. Life cycle assessment attributes most impacts to grid electricity, with a global warming potential of 0.210-0.241 kg CO2 eq./kg input; a low-carbon grid cuts this by 62.8%. This paired baseline enables benchmarking of emerging recycling routes and supports circular battery supply chains.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 10","pages":"117729"},"PeriodicalIF":4.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0