iScience最新文献_第2页

Fatty acid abnormalities in cystic fibrosis–the missing link for a cure? 囊性纤维化的脂肪酸异常--治愈的缺失环节？

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111153

Sławomira Drzymała-Czyż , Jarosław Walkowiak , Carla Colombo , Gianfranco Alicandro , Olav Trond Storrösten , Magnhild Kolsgaard , Egil Bakkeheim , Birgitta Strandvik

{"title":"Fatty acid abnormalities in cystic fibrosis–the missing link for a cure?","authors":"Sławomira Drzymała-Czyż , Jarosław Walkowiak , Carla Colombo , Gianfranco Alicandro , Olav Trond Storrösten , Magnhild Kolsgaard , Egil Bakkeheim , Birgitta Strandvik","doi":"10.1016/j.isci.2024.111153","DOIUrl":"10.1016/j.isci.2024.111153","url":null,"abstract":"<div><div>The care for cystic fibrosis (CF) has dramatically changed with the development of modulators, correctors, and potentiators of the CFTR molecule, which lead to improved clinical status of most people with CF (pwCF). The modulators influence phospholipids and ceramides, but not linoleic acid (LA) deficiency, associated with more severe phenotypes of CF. The LA deficiency is associated with upregulation of its transfer to arachidonic acid (AA). The AA release from membranes is increased and associated with increase of pro-inflammatory prostanoids and the characteristic inflammation is present before birth and bacterial infections. Docosahexaenoic acid is often decreased, especially in associated liver disease Some endogenously synthesized fatty acids are increased. Cholesterol and ceramide metabolisms are disturbed. The lipid abnormalities are present at birth, and before feeding in transgenic pigs and ferrets. This review focus on the lipid abnormalities and their associations to clinical symptoms in CF, based on clinical studies and experimental research.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111153"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142662681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis 细胞癌变过程中代谢和表观遗传修饰之间的相互影响

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111359

Yue Gao , Siyu zhang , Xianhong Zhang , Yitian Du , Ting Ni , Shuailin Hao

{"title":"Crosstalk between metabolic and epigenetic modifications during cell carcinogenesis","authors":"Yue Gao , Siyu zhang , Xianhong Zhang , Yitian Du , Ting Ni , Shuailin Hao","doi":"10.1016/j.isci.2024.111359","DOIUrl":"10.1016/j.isci.2024.111359","url":null,"abstract":"<div><div>Genetic mutations arising from various internal and external factors drive cells to become cancerous. Cancerous cells undergo numerous changes, including metabolic reprogramming and epigenetic modifications, to support their abnormal proliferation. This metabolic reprogramming leads to the altered expression of many metabolic enzymes and the accumulation of metabolites. Recent studies have shown that these enzymes and metabolites can serve as substrates or cofactors for chromatin-modifying enzymes, thereby participating in epigenetic modifications and promoting carcinogenesis. Additionally, epigenetic modifications play a role in the metabolic reprogramming and immune evasion of cancer cells, influencing cancer progression. This review focuses on the origins of cancer, particularly the metabolic reprogramming of cancer cells and changes in epigenetic modifications. We discuss how metabolites in cancer cells contribute to epigenetic remodeling, including lactylation, acetylation, succinylation, and crotonylation. Finally, we review the impact of epigenetic modifications on tumor immunity and the latest advancements in cancer therapies targeting these modifications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111359"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of nanomaterials in revolutionizing ischemic stroke treatment: Current trends and future prospects

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111373

Yong Wang , Huiying Che , Linzhuo Qu , Xin Lu , Mingzhen Dong , Bo Sun , Hongjian Guan

{"title":"The role of nanomaterials in revolutionizing ischemic stroke treatment: Current trends and future prospects","authors":"Yong Wang , Huiying Che , Linzhuo Qu , Xin Lu , Mingzhen Dong , Bo Sun , Hongjian Guan","doi":"10.1016/j.isci.2024.111373","DOIUrl":"10.1016/j.isci.2024.111373","url":null,"abstract":"<div><div>Ischemic stroke has a high disability rate, which leads to irreversible neuronal death. The efficacy of conventional stroke treatments, including thrombolytic and neuroprotective therapies, is constrained by a number of factors, including safety concerns and inefficient drug delivery. The advent of nanomaterials has created new avenues for stroke therapy, facilitating enhanced pharmacokinetic behavior of drugs, effective drug accumulation at the target site, augmented therapeutic efficacy, and concomitant reduction in side effects. Therefore, this paper pioneers a research approach that summarized the development trend and clinical value of nanomaterials in the field of ischemic stroke through bibliometric analysis. This review provides an overview of the pathophysiological mechanisms of stroke and examines the current research trends in the use of nanomaterials in stroke management. It encompasses a multitude of domains, including targeted drug delivery systems, biosensors for the sensitive detection of biomarkers, and neuroprotective nanotechnologies capable of traversing the blood-brain barrier. Moreover, we investigate the challenges that nanomaterials encounter in the clinical translation context, including those pertaining to biocompatibility and long-term safety. These results have provided the clinical value and limitations of nanomaterials in the diagnosis and treatment of ischemic stroke from double perspectives, thereby offering new avenues for the further development of innovative nanotherapeutic tools.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111373"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142748511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle 光-暗和行为周期延迟 5 小时后人体新陈代谢的短期变化

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111161

Alan Flanagan , Leonie C. Ruddick-Collins , Barbara Fielding , Benita Middleton , Johanna von Gerichten , Michael Short , Victoria Revell , Jeewaka Mendis , Claus-Dieter Mayer , Peter J. Morgan , Alexandra M. Johnstone , Jonathan D. Johnston

{"title":"Short-term changes in human metabolism following a 5-h delay of the light-dark and behavioral cycle","authors":"Alan Flanagan , Leonie C. Ruddick-Collins , Barbara Fielding , Benita Middleton , Johanna von Gerichten , Michael Short , Victoria Revell , Jeewaka Mendis , Claus-Dieter Mayer , Peter J. Morgan , Alexandra M. Johnstone , Jonathan D. Johnston","doi":"10.1016/j.isci.2024.111161","DOIUrl":"10.1016/j.isci.2024.111161","url":null,"abstract":"<div><div>Experimental inversion of circadian and behavioral rhythms by 12 h adversely affects markers of metabolic health. We investigated the effects of a more modest 5-h delay in behavioral cycles. Fourteen participants completed an 8-day in-patient laboratory protocol, with controlled sleep-wake opportunities, light-dark cycles, and diet. The 5-h delay in behavioral cycles was induced by delaying sleep opportunity. We measured melatonin to confirm central circadian phase, fasting markers and postprandial metabolism, energy expenditure, subjective sleepiness, and appetite, throughout the waking period. After the phase delay, there was slower gastric emptying at breakfast, lower fasting plasma glucose, higher postprandial plasma glucose and triglycerides, and lower thermic effect of feeding. Any changes were abolished or attenuated within 48–72 h. These data extend our previous findings, which showed no time-of-day effect in healthy adults on daytime energy expenditure or thermic effect of feeding when accounting for circadian variation in resting metabolic rate.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111161"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drug nanocrystals: Surface engineering and its applications in targeted delivery 药物纳米晶体：表面工程及其在靶向给药中的应用。

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111185

Phattalapol Lhaglham , Luksika Jiramonai , Yaru Jia , Baoying Huang , Yuanyu Huang , Xueyun Gao , Jinchao Zhang , Xing-Jie Liang , Mengliang Zhu

{"title":"Drug nanocrystals: Surface engineering and its applications in targeted delivery","authors":"Phattalapol Lhaglham , Luksika Jiramonai , Yaru Jia , Baoying Huang , Yuanyu Huang , Xueyun Gao , Jinchao Zhang , Xing-Jie Liang , Mengliang Zhu","doi":"10.1016/j.isci.2024.111185","DOIUrl":"10.1016/j.isci.2024.111185","url":null,"abstract":"<div><div>Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug bioavailability and treatment effectiveness. Recent advances in preparation techniques have facilitated research on drug surface properties, leading to valuable surface engineering strategies. Surface modification can stabilize drug nanocrystals, making them suitable for versatile drug delivery platforms. Functionalized ligands further enhance the potential for targeted delivery, enabling precision medicine. This review focuses on the surface engineering of drug nanocrystals, discussing various preparation methods, surface ligand design strategies, and their applications in targeted drug delivery, especially for cancer treatments. Finally, challenges and future directions are also discussed to promote the development of drug nanocrystals. The surface engineering of drug nanocrystals promises new opportunities for treating complex and chronic diseases while broadening the application of drug delivery systems.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111185"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A strategic approach to evaluating battery innovation investments 评估电池创新投资的战略方法

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111075

Rahul Malik , Koen Bertens , René-Pierre Allard , Katherine Thompson , Jennifer Hiscock , Cynthia Handler , Amanda Wilson

{"title":"A strategic approach to evaluating battery innovation investments","authors":"Rahul Malik , Koen Bertens , René-Pierre Allard , Katherine Thompson , Jennifer Hiscock , Cynthia Handler , Amanda Wilson","doi":"10.1016/j.isci.2024.111075","DOIUrl":"10.1016/j.isci.2024.111075","url":null,"abstract":"<div><div>Driven predominantly by public and private innovation, rechargeable batteries have, over a few decades, graduated from powering luxury consumer electronics to becoming one of the linchpins of the energy transition. Rapid adoption trends of batteries must accelerate to meet global net-zero targets for mobility and stationary storage, and will require making sound investments in battery innovation that deliver the most value. Because battery innovation is increasingly complex, multi-disciplinary, and subject to the coordination of stakeholders across academia, industry, government, and the broader public, building common and intuitive frameworks for understanding becomes critical to making progress. In this <em>Perspective</em>, we present and employ five conceptual, descriptive, technical, and social frameworks that, taken together, provide a holistic assessment of innovation opportunities in the battery sector. Finally, we illustrate their implementation as the foundation of the <em>Strategic Approach to Battery Innovation</em> pursued by the Government of Canada’s Office of Energy Research and Development.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111075"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triglyceride index as a predictor of mortality after cardiac surgery 预测心脏手术后死亡率的甘油三酯指数

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111107

Huili Li , Fei Xiao , Haiqiang Ren , Fei Xu , Hao Che , Huadong Zhu , Chenghui Zhou , Sheng Wang

{"title":"Triglyceride index as a predictor of mortality after cardiac surgery","authors":"Huili Li , Fei Xiao , Haiqiang Ren , Fei Xu , Hao Che , Huadong Zhu , Chenghui Zhou , Sheng Wang","doi":"10.1016/j.isci.2024.111107","DOIUrl":"10.1016/j.isci.2024.111107","url":null,"abstract":"<div><h3>Background</h3><div>The triglyceride-glucose (TyG) index, a marker for insulin resistance, has been linked to adverse cardiac outcomes. Its role in predicting mortality following cardiac surgery remains unclear.</div></div><div><h3>Methods</h3><div>This study analyzed 1,810 cardiac surgery patients from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, categorized by TyG index levels. Mortality was the primary outcome, assessed through Cox proportional hazards regression, time-dependent receiver operating characteristic (ROC) analysis, and restricted cubic splines.</div></div><div><h3>Results</h3><div>Over a 13-year follow-up, 83 patients died. Higher TyG index levels were associated with increased mortality risk (hazard ratio [HR] = 1.206, 95% confidence interval [CI], 1.121–1.297, <em>p</em> < 0.001). Time-dependent ROC analysis showed areas under the curve (AUCs) of 0.914, 0.857, and 0.801 at 1, 3, and 5 years, respectively. The TyG index-based model outperformed established scoring systems in predicting mortality.</div></div><div><h3>Conclusions</h3><div>Elevated TyG index levels are significantly associated with higher mortality risk after cardiac surgery, highlighting its potential as a prognostic marker in this population.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111107"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Personalized and adaptive interventions for smoking cessation: Emerging trends and determinants of efficacy 个性化和适应性戒烟干预：新趋势和疗效的决定因素

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111090

Gal Cohen , Carlo Maria Bellanca , Renato Bernardini , Jed E. Rose , Riccardo Polosa

{"title":"Personalized and adaptive interventions for smoking cessation: Emerging trends and determinants of efficacy","authors":"Gal Cohen , Carlo Maria Bellanca , Renato Bernardini , Jed E. Rose , Riccardo Polosa","doi":"10.1016/j.isci.2024.111090","DOIUrl":"10.1016/j.isci.2024.111090","url":null,"abstract":"<div><div>Cigarette smoking addiction is a leading cause of morbidity and mortality and presents a challenging interventional target. Interventions for stopping smoking offer trade-offs in ability to displace or blunt the effects of cigarettes, which include positive and negative reinforcement, psychological reward, aversiveness, and sensory enjoyment, and which are mediated through nicotine and non-nicotine elements of smoking. Established therapies, which include nicotine replacement therapies (NRTs), varenicline, and bupropion are being supplemented with a growing evidence base for cytisine and nicotine substitution products, with more rapid acting NRTs on the horizon, all of which are expanding individual choice. An understanding of determinants of efficacy can inform a personalized and adaptive approach to smoking cessation, which presents an opportunity to further improve outcomes. This includes tailoring cessation treatment plans based on initial individual response, preference, and tolerability to first line interventions and considering second-line options (including evidence-based combination therapies) when needed.</div></div><div><h3>Video Abstract</h3><div><span><span><span><span><video><source></source></video></span><span><span>Download: <span>Download video (61MB)</span></span></span></span></span></span></div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111090"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and validation of machine learning models for intraoperative blood transfusion prediction in severe lumbar disc herniation 用于严重腰椎间盘突出症术中输血预测的机器学习模型的开发与验证

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-15 DOI: 10.1016/j.isci.2024.111106

Qiang Liu , An-Tian Chen , Runmin Li , Liang Yan , Xubin Quan , Xiaozhu Liu , Yang Zhang , Tianyu Xiang , Yingang Zhang , Anfa Chen , Hao Jiang , Xuewen Hou , Qizhong Xu , Weiheng He , Liang Chen , Xin Zhou , Qiang Zhang , Wei Huang , Haopeng Luan , Xinghua Song , Wenle Li

{"title":"Development and validation of machine learning models for intraoperative blood transfusion prediction in severe lumbar disc herniation","authors":"Qiang Liu , An-Tian Chen , Runmin Li , Liang Yan , Xubin Quan , Xiaozhu Liu , Yang Zhang , Tianyu Xiang , Yingang Zhang , Anfa Chen , Hao Jiang , Xuewen Hou , Qizhong Xu , Weiheng He , Liang Chen , Xin Zhou , Qiang Zhang , Wei Huang , Haopeng Luan , Xinghua Song , Wenle Li","doi":"10.1016/j.isci.2024.111106","DOIUrl":"10.1016/j.isci.2024.111106","url":null,"abstract":"<div><div>Lumbar disc herniation (LDH) is a common cause of lower back pain and sciatica, and posterior lumbar interbody fusion (PLIF) is always employed. This multicenter retrospective study investigates predicting intraoperative blood transfusion for LDH patients undergoing PLIF in China. The research includes 6,241 patients from 22 medical centers and employs 8 feature selection methods and 10 machine learning models, including an integrated stacking model. The optimal predictive model was selected based on the receiver operating characteristic area under the curve, clinical applicability, and computational efficiency. Among the evaluated combinations, the simulated annealing support vector machine recursive + stacking model achieved the highest performance with an area under the curve of 0.884, supported by robust calibration and decision curve analyses. A publicly accessible web calculator was developed to assist clinicians in decision-making. This work significantly enhances intraoperative transfusion predictions, providing valuable tools for improving patient management.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 11","pages":"Article 111106"},"PeriodicalIF":4.6,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142663193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Red blood cell trapping using single-beam acoustic tweezers in the Rayleigh regime 利用单束声镊在瑞利模式下捕获红细胞

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-14 DOI: 10.1016/j.isci.2024.111324

Jinhee Yoo, Jinhyuk Kim, Jungwoo Lee, Hyung Ham Kim

引用次数: 0