iScience最新文献_第2页

Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice. 齿状回和CA3活性介导小鼠浅色二级条件反射的表达。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-30 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115522

Marc Canela, Jordi Bach Adell, David Roura Coll, Jose Antonio González-Parra, Julia S Pinho, Arnau Busquets-García

{"title":"Dentate gyrus and CA3 activity mediates light-tone second-order conditioning expression in mice.","authors":"Marc Canela, Jordi Bach Adell, David Roura Coll, Jose Antonio González-Parra, Julia S Pinho, Arnau Busquets-García","doi":"10.1016/j.isci.2026.115522","DOIUrl":"10.1016/j.isci.2026.115522","url":null,"abstract":"Second-order conditioning (SOC) enables animals to form predictions about their environment without direct reinforcement. Although the neural basis of first-order conditioning (FOC) is well characterized, the circuits supporting SOC recall remain unclear. Here, we investigated the brain regions and cell types involved in SOC retrieval in mice and addressed the challenge of quantifying brain-wide neural activity. Using a light-tone SOC paradigm in TRAP2:Ai14 mice, we tagged neurons active during SOC recall by expressing tdTomato fluorescent protein. We quantified the fluorescent cells in brain slices with CellRake, a self-developed Python package. We applied generalized linear models that revealed that activity in the dentate gyrus (DG) and cornu ammonis 3 (CA3) subfields of the dorsal hippocampus was associated with SOC-related behavioral responses. Chemogenetic inhibition of CaMKII+ neurons in these regions reduced SOC recall, supporting a causal contribution of DG/CA3 circuits. These findings identify the dorsal hippocampus as a key substrate for retrieving indirectly learned associations.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115522"},"PeriodicalIF":4.1,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interpretable neural network for risk stratification and drug target discovery based on PBMC transcriptomes. 基于PBMC转录组的风险分层和药物靶标发现的可解释神经网络。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-30 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115538

Ziqing Yu, Liwei Liu, Yugang Zou, Yue Liu, Liming Chen, Lulu Peng, Wei Chen, Jing Wang, Kun Yin, Zhiwei Zhang, Suling Ding, Qinqin Hu

{"title":"Interpretable neural network for risk stratification and drug target discovery based on PBMC transcriptomes.","authors":"Ziqing Yu, Liwei Liu, Yugang Zou, Yue Liu, Liming Chen, Lulu Peng, Wei Chen, Jing Wang, Kun Yin, Zhiwei Zhang, Suling Ding, Qinqin Hu","doi":"10.1016/j.isci.2026.115538","DOIUrl":"10.1016/j.isci.2026.115538","url":null,"abstract":"Peripheral blood mononuclear cells (PBMCs) play a central role in immune surveillance and disease pathogenesis and provide a minimally invasive source for molecular screening. Here, we developed ME-NET, an intrinsically interpretable deep learning framework for multi-disease screening and risk stratification from PBMC transcriptomic profiles. Using harmonized datasets from heterogeneous clinical backgrounds, ME-NET showed consistent performance and outperformed standard machine-learning baselines. By incorporating curated pathway priors in a pathway-informed layer, ME-NET connects predictions to pathway-level signals and contributing genes, enabling biologically grounded interpretation of disease-associated immune programs. Finally, integrating ME-NET-prioritized targets with drug-gene interaction resources identified candidate compounds for potential therapeutic repurposing. Collectively, these results support the use of interpretable deep learning on blood-derived transcriptomes for scalable multi-disease screening and for prioritizing biomarkers and drug targets.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115538"},"PeriodicalIF":4.1,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy. ph响应叶酸- peg修饰的ZIF-8纳米颗粒将非瑟酮传递给水通道蛋白-3用于宫颈癌治疗。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-30 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115521

Hanlin Yang, Weiwei Li, Hailong Zhang, Yameng Liu, Miaomiao Cui, Yurong Zhu, Li Hou, Shaoju Min, Jie Ren, Yujie Tan

{"title":"pH-responsive Folate-PEG modified ZIF-8 Nanoparticles deliver fisetin to Aquaporin-3 for cervical cancer therapy.","authors":"Hanlin Yang, Weiwei Li, Hailong Zhang, Yameng Liu, Miaomiao Cui, Yurong Zhu, Li Hou, Shaoju Min, Jie Ren, Yujie Tan","doi":"10.1016/j.isci.2026.115521","DOIUrl":"10.1016/j.isci.2026.115521","url":null,"abstract":"Conventional cervical cancer therapies often cause severe side effects and face recurrence challenges. Although the natural flavonoid fisetin (FIS) exhibits strong anticancer properties, its clinical utility is restricted by poor aqueous solubility. To overcome this, we engineered a tumor-targeting nanotherapeutic, PEG-FA@ZIF-8@FIS, by encapsulating FIS within a zeolitic imidazolate framework-8 (ZIF-8) core surface-functionalized with polyethylene glycol-folic acid (PEG-FA). Both in vitro and in vivo models demonstrate that this system effectively suppresses cancer cell proliferation, migration, and tumor growth with excellent biocompatibility. Mechanistically, transcriptomic and lipidomic analyses reveal that PEG-FA@ZIF-8@FIS exerts its anticancer effects by downregulating aquaporin-3 (AQP3) expression, which subsequently disrupts tumor lipid metabolism. By linking AQP3 inhibition to metabolic impairment via a targeted delivery platform, this work establishes a highly biocompatible and effective translational strategy for cervical cancer intervention.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115521"},"PeriodicalIF":4.1,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice. 新生儿缺氧缺血性脑损伤对小鼠脾后皮层和海马深层神经动力学的长期影响。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-28 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115003

Lida Du, Meng Yang, Hendrik W Steenland, Zhengwei Luo, Andrea Ovcjak, Ruiyan Hu, Shuzo Sugita, Kaori Takehara-Nishiuchi, Luka Milosevic, Zhong-Ping Feng

{"title":"The long-term impact of neonatal hypoxic-ischemic brain injury on neural dynamics in deep-layer retrosplenial cortex and hippocampus in mice.","authors":"Lida Du, Meng Yang, Hendrik W Steenland, Zhengwei Luo, Andrea Ovcjak, Ruiyan Hu, Shuzo Sugita, Kaori Takehara-Nishiuchi, Luka Milosevic, Zhong-Ping Feng","doi":"10.1016/j.isci.2026.115003","DOIUrl":"10.1016/j.isci.2026.115003","url":null,"abstract":"Perinatal hypoxic-ischemia (HI) often results in hypoxic-ischemic encephalopathy (HIE), a major cause of neonatal mortality and long-term neurodevelopmental deficits. While motor and cognitive impairments are common, the underlying neuronal mechanisms remain poorly understood. Using a mouse model of neonatal HI, we examined long-term effects on neuronal activity in the retrosplenial cortex (RSC) and hippocampus through simultaneous electrophysiological recordings in freely moving adults. HI mice showed a significant reduction in neurons recorded per tetrode, and remaining pyramidal neurons in the ipsilateral hemisphere exhibited abnormal bursting, synchrony, and pathological spike-field coupling to theta-alpha oscillations. These neural abnormalities coincided with impaired motor learning performance across training sessions. Our findings reveal persistent disruptions in firing patterns and RSC-hippocampus communication, providing insight into long-term motor learning deficits at the single-neuron level, following neonatal HI brain injury.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115003"},"PeriodicalIF":4.1,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PHF2 regulates grip strength via demethylation at the promoter region of the Mef2c. PHF2通过Mef2c启动子区域的去甲基化调节握力。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-28 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115517

Taku Fukushima, Taiju Fujioka, Yuuki Imai, Satoru Masubuchi, Iori Sakakibara

{"title":"PHF2 regulates grip strength via demethylation at the promoter region of the Mef2c.","authors":"Taku Fukushima, Taiju Fujioka, Yuuki Imai, Satoru Masubuchi, Iori Sakakibara","doi":"10.1016/j.isci.2026.115517","DOIUrl":"10.1016/j.isci.2026.115517","url":null,"abstract":"Epigenetic modifications, including DNA methylation and histone modifications, play crucial roles in gene expression. Although histone H3 lysine-9 methylation (H3K9me) is a highly conserved repressive mark in heterochromatin regions, its specific function in skeletal muscle remains unclear. Here we demonstrate that PHF2, an H3K9me2 demethylase, is essential for skeletal muscle function, particularly in fast-twitch muscle fibers. Skeletal muscle-specific Phf2 knockout mice exhibited significantly reduced grip strength compared to controls. PHF2 differentially regulates protein metabolism and energy homeostasis between fast- and slow-twitch fibers, with more pronounced effects in fast-twitch muscles. Moreover, we found that PHF2 predominantly binds to transcription start site (TSS)-downstream regions of key genes, including Mef2c, which play a critical role in muscle function. Notably, PHF2 binding sites were enriched in pathways associated with protein regulation, cellular homeostasis, and muscle function. These findings reveal PHF2's broader regulatory role in maintaining muscle health and performance.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115517"},"PeriodicalIF":4.1,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the sleep benefits of Nature-Based Interventions: Evidence from a Bayesian Network meta-analysis. 比较基于自然的干预对睡眠的好处：来自贝叶斯网络元分析的证据。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-28 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115513

Cong Ma, Aamir Mehmood Shah, Wei Chen, Zongsheng Li, Yi Peng, Ruohan Wu, Xinyu Du, Hao Li, Bingyang Lv, Shiliang Liu, Qibing Chen

{"title":"Comparing the sleep benefits of Nature-Based Interventions: Evidence from a Bayesian Network meta-analysis.","authors":"Cong Ma, Aamir Mehmood Shah, Wei Chen, Zongsheng Li, Yi Peng, Ruohan Wu, Xinyu Du, Hao Li, Bingyang Lv, Shiliang Liu, Qibing Chen","doi":"10.1016/j.isci.2026.115513","DOIUrl":"https://doi.org/10.1016/j.isci.2026.115513","url":null,"abstract":"Sleep health represents a growing global public health concern, underscoring the urgent need for scalable non-pharmacological interventions. We conducted a Bayesian network meta-analysis of randomized controlled trials (RCTs) to synthesize comparative evidence on sensory-oriented nature-based interventions (NBIs) for sleep health in adults. Across the evidence network, all intervention categories consistently outperformed conventional care, whereas between-modality differences were generally modest. This suggests that the therapeutic benefits stem from a shared effect of nature exposure, rather than a single dominant mechanistic pathway. Robustness analyses confirmed the stability and reliability of the comparative effect estimates. These findings provide an integrative synthesis of randomized evidence and support NBIs as accessible, scalable strategies to improve sleep health. They also underscore the critical need for larger, more rigorously designed RCTs to refine estimates of the comparative effectiveness of different NBI modalities.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115513"},"PeriodicalIF":4.1,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia. HIF-1α和AhR的功能分离控制NK细胞在缺氧条件下的反应性。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-27 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115492

Sebastiano Giorgetta, Francesco Cortopassi, Theodoros Chanis, Jing Ni, Margareta P Correia, Carsten Sticht, Volker Ast, Michael Platten, Adelheid Cerwenka, Ana Stojanovic

{"title":"Functional segregation of HIF-1α and AhR controls NK cell responsiveness under hypoxia.","authors":"Sebastiano Giorgetta, Francesco Cortopassi, Theodoros Chanis, Jing Ni, Margareta P Correia, Carsten Sticht, Volker Ast, Michael Platten, Adelheid Cerwenka, Ana Stojanovic","doi":"10.1016/j.isci.2026.115492","DOIUrl":"https://doi.org/10.1016/j.isci.2026.115492","url":null,"abstract":"Multiple mechanisms operate to transform microenvironmental information into cellular adaptation, but how environmental sensors mechanistically synergize to fine-tune natural killer (NK) cell functions is underexplored. Although the deletion of HIF-1α, the sensor for hypoxia, was shown to impact NK cell responses, we here demonstrate that hypoxia-inflicted adaptations in NK cells are differentially hard-wired through HIF-1α. The hypoxia-HIF-1α axis repressed NK cell oxidative metabolism and the response to IL-12/18 through transcription. However, the IL-12/18-induced IFN-γ production was preserved under hypoxia. This was attributed to the activation of the aryl-hydrocarbon receptor (AhR) that magnified the engagement of the cMyc-mTORC1-IκBζ pathway, resulting in elevated IFN-γ expression. NK cells harmonized AhR/HIF-1α-mediated signals through defined transcriptional modules, also detected in similar microenvironments, such as in solid tumors. Together, NK cell functions are fine-tuned through regulatory networks controlled by environmental sensors, which act as superordinate checkpoints for NK cell outputs.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115492"},"PeriodicalIF":4.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemispheric asymmetry in depressive symptoms is associated with sex-divergent functional brain connectivity patterns. 抑郁症状的半球不对称与性别差异的功能性脑连接模式有关。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-27 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115481

Shuqi Jia, Weizhi Liu, Qun Zhao, Somang Yun, Xin Xin, Cong Liu, Shufan Li, Peng Wang, Zhaosong Yin, Wei Guan, Fen Yu, Qing Liu, Zhaohui Guo, Xi Wang, Xing Wang

{"title":"Hemispheric asymmetry in depressive symptoms is associated with sex-divergent functional brain connectivity patterns.","authors":"Shuqi Jia, Weizhi Liu, Qun Zhao, Somang Yun, Xin Xin, Cong Liu, Shufan Li, Peng Wang, Zhaosong Yin, Wei Guan, Fen Yu, Qing Liu, Zhaohui Guo, Xi Wang, Xing Wang","doi":"10.1016/j.isci.2026.115481","DOIUrl":"10.1016/j.isci.2026.115481","url":null,"abstract":"Hemispheric asymmetry has been linked to depressive symptoms, yet its relationship with large-scale brain network organization remains unclear. Resting-state electroencephalography (EEG) was recorded from 489 university students to examine hemispheric asymmetry associated with depressive symptoms and its relation to functional connectivity, with attention to sex-dependent patterns. Asymmetry indices and connectivity strength and density were computed across six frequency bands. Depressive symptoms were primarily associated with asymmetry alterations in the α and δ bands, most prominently in frontal α1 asymmetry. At the network level, elevated depressive symptoms were linked to reduced connectivity strength and density, particularly in the α2 and β1 bands, with significant sex × depressive symptom interactions. Alpha2-band connectivity statistically explained a proportion of the association between depressive symptoms and multiple asymmetry indices. These findings indicate that hemispheric asymmetry co-occurs with frequency- and sex-dependent variations in large-scale functional brain organization.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115481"},"PeriodicalIF":4.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ti-15Zr-5.5Cu: A dental titanium alloy with robust antibacterial activity and superior corrosion resistance. Ti-15Zr-5.5Cu：一种具有强大抗菌活性和优异耐腐蚀性的牙科钛合金。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-27 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115499

Nan Shi, Diaofeng Li, Jingyu Tan, Yingfei Chen, Zining Cui, Qiang Wang, Chunguang Bai, Lin Wu, Zhongheng Yang

{"title":"Ti-15Zr-5.5Cu: A dental titanium alloy with robust antibacterial activity and superior corrosion resistance.","authors":"Nan Shi, Diaofeng Li, Jingyu Tan, Yingfei Chen, Zining Cui, Qiang Wang, Chunguang Bai, Lin Wu, Zhongheng Yang","doi":"10.1016/j.isci.2026.115499","DOIUrl":"https://doi.org/10.1016/j.isci.2026.115499","url":null,"abstract":"Ti-15Zr-5.5Cu alloys were fabricated via vacuum self-consumable arc melting, yielding a yield strength of 780 ± 10 MPa and tensile strength of 845 ± 8 MPa, indicating excellent tensile properties and plasticity. Antibacterial performance was evaluated against Porphyromonas gingivalis, showing 89% inhibition of adherent bacteria and 12% inhibition of planktonic bacteria after 24 h. Mechanistic studies revealed that Cu incorporation induced oxidative stress, evidenced by elevated reactive oxygen species (ROS) fluorescence, increased protein, and reducing sugar leakage, and enhanced lipid peroxidation, leading to bacterial membrane damage and permeability increase. Corrosion tests demonstrated that Ti-15Zr-5.5Cu alloys exhibited superior resistance compared to pure Ti and Ti-15Zr, particularly in H2O2-rich environments. Electrochemical tests in artificial saliva, with and without 200 μM H2O2, revealed superior corrosion resistance, with a charge transfer resistance (Rip) reaching 29.2 × 105 Ω·cm2 (in standard saliva) and 52.59 × 105 Ω·cm2 (in H2O2-containing saliva) after 5 days, significantly higher than control materials. These findings elucidate the antibacterial mechanisms of Cu-containing biomedical alloys and provide guidance for the design of next-generation dental and orthopedic implants.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115499"},"PeriodicalIF":4.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147758834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbon nanotube fibers as high-fidelity sensors for carbon nanotube/polymer nanocomposites. 碳纳米管纤维作为碳纳米管/聚合物纳米复合材料的高保真传感器。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-27 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115498

Sergei P Shadrov, Hassaan A Butt, Aliya R Vildanova, Ekaterina E Agafonova, Veronika A Dmitrieva, Vladislav A Kondrashov, Yaotian Yan, Junlei Qi, Zeyu Wang, Dmitry V Krasnikov, Omid Akhavan, Albert G Nasibulin

{"title":"Carbon nanotube fibers as high-fidelity sensors for carbon nanotube/polymer nanocomposites.","authors":"Sergei P Shadrov, Hassaan A Butt, Aliya R Vildanova, Ekaterina E Agafonova, Veronika A Dmitrieva, Vladislav A Kondrashov, Yaotian Yan, Junlei Qi, Zeyu Wang, Dmitry V Krasnikov, Omid Akhavan, Albert G Nasibulin","doi":"10.1016/j.isci.2026.115498","DOIUrl":"10.1016/j.isci.2026.115498","url":null,"abstract":"Carbon nanotube fibers (CNTFs) enable real-time dual-stage monitoring of CNT/epoxy nanocomposites via single-step embedding during manufacturing. Although highly sensitive, CNTF responses can be influenced by environmental and processing factors that introduce sensor artifacts and response lag. Here, we quantitatively assess, for the first time, the accuracy of CNTF sensing in multifunctional epoxy nanocomposites. CNTFs were fabricated via the wet-pulling of single-walled CNT (SWCNT) thin films (18, 39, and 59 nm thickness) and embedded in epoxy containing 0.005 and 0.5 wt. % single- and multiwalled CNTs (MWCNTs). Electrical measurements were conducted using 2- and 4-point techniques. CNTFs showed negligible measurement inaccuracy of less than 10-6% and 10-1% for MW- and SWCNT nanocomposites, respectively. Owing to their virtually contact-resistance-free behavior, CNTFs achieve 1-2 orders of magnitude higher accuracy than standard surface-applied electrodes. These results establish CNTFs as high-fidelity, low-artefact sensors capable of monitoring multifunctional epoxy nanocomposites better than existing techniques.","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115498"},"PeriodicalIF":4.1,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13092065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0