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Cost trajectory of hydrogen fuel cell technology in China

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112359

Xue Wang , Li-Wei Fan , Hongyan Zhang , Peng Zhou

引用次数: 0

Ensuring low-emission electricity purchasing requires a broader systems perspective

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112349

Lissy Langer , Kenneth Bruninx , Anders Bjørn , Lukas Barner , Julien Lavalley , Hadi Vatankhah Ghadim , Rasmus Bramstoft

{"title":"Ensuring low-emission electricity purchasing requires a broader systems perspective","authors":"Lissy Langer , Kenneth Bruninx , Anders Bjørn , Lukas Barner , Julien Lavalley , Hadi Vatankhah Ghadim , Rasmus Bramstoft","doi":"10.1016/j.isci.2025.112349","DOIUrl":"10.1016/j.isci.2025.112349","url":null,"abstract":"<div><div>Introducing electricity purchase conditions in renewable fuel regulations and carbon accounting is a controversial issue in the US and Europe. We argue that their impact must be assessed considering demand flexibility, local grid conditions, and overlapping policy instruments such as emissions trading schemes and renewable portfolio standards. The introduction of more stringent requirements has a significant impact on companies' reported progress in reducing indirect emissions. In addition, we currently lack reliable carbon intensity data with sufficient temporal and spatial granularity outside the US and Europe. Assessing hydrogen imports should consider strategic behavior. In summary, a broader systems perspective is needed to analyze the impact of electricity purchase conditions on markets, prices, and emissions, integrating voluntary actions to decarbonize hard-to-abate sectors under increasing renewable energy shares. This will have implications not only for the (re)design and integration of certificate markets for renewable electricity but also for renewable fuels and carbon.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112349"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Neuroactive steroids activate membrane progesterone receptors to induce sex specific effects on protein kinase activity

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112352

Abigail H.S. Lemons , Briana Murphy , Jake S. Dengler , Seda Salar , Paul A. Davies , Joshua L. Smalley , Stephen J. Moss

{"title":"Neuroactive steroids activate membrane progesterone receptors to induce sex specific effects on protein kinase activity","authors":"Abigail H.S. Lemons , Briana Murphy , Jake S. Dengler , Seda Salar , Paul A. Davies , Joshua L. Smalley , Stephen J. Moss","doi":"10.1016/j.isci.2025.112352","DOIUrl":"10.1016/j.isci.2025.112352","url":null,"abstract":"<div><div>Neuroactive steroids (NAS), which are synthesized in the brain from progesterone, exert potent effects on behavior and are used to treat postpartum depression, yet how these compounds induce sustained modifications in neuronal activity are ill-defined. Here, we examined the efficacy of NAS for membrane progesterone receptors (mPRs) δ and ε, members of a family of GPCRs for progestins that are expressed in the CNS. NAS increase PKC activity via the G<sub>q</sub> activation of mPRδ with EC50s between 3 and 11nM. In contrast, they activate G<sub>s</sub> via mPRε to potentiate PKA activity with similar potencies. NAS also induced the rapid internalization of only mPRδ. In the forebrain of female mice, mPRδ expression levels were 8-fold higher than in males. Consistent with this, the activation of PKC by NAS was evident in acute brain slices from female mice. Collectively, our results suggest that NAS may exert sex-specific effects on intracellular signaling in the brain via the activation of mPRs.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112352"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Opportunities and Challenges for People-Centred Multi-Hazard Early Warning Systems: Perspectives from the Global South

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112353

Budimir Mirianna , Šakić Trogrlić Robert , Almeida Cinthia , Arestegui Miguel , Chuquisengo Vásquez Orlando , Cisneros Abel , Cuba Iriarte Monica , Dia Adama , Lizon Leon , Madueño Giorgio , Ndiaye Alioune , Ordoñez Caldas Miluska , Rahman Tamanna , RanaTharu Bikram , Sall Alpha , Uprety Dharam , Anderson Chris , McQuistan Colin

{"title":"Opportunities and Challenges for People-Centred Multi-Hazard Early Warning Systems: Perspectives from the Global South","authors":"Budimir Mirianna , Šakić Trogrlić Robert , Almeida Cinthia , Arestegui Miguel , Chuquisengo Vásquez Orlando , Cisneros Abel , Cuba Iriarte Monica , Dia Adama , Lizon Leon , Madueño Giorgio , Ndiaye Alioune , Ordoñez Caldas Miluska , Rahman Tamanna , RanaTharu Bikram , Sall Alpha , Uprety Dharam , Anderson Chris , McQuistan Colin","doi":"10.1016/j.isci.2025.112353","DOIUrl":"10.1016/j.isci.2025.112353","url":null,"abstract":"<div><div>This perspective critically examines the challenges and opportunities of implementing people-centred Multi-Hazard Early Warning Systems (MHEWS) in the Global South. Despite global initiatives, such as the Early Warnings for All initiative, operational realities lag behind. By exploring the needs of the most vulnerable and how core concepts of multi-hazard thinking (e.g., hazard interrelationships and vulnerability dynamics) integrate into different pillars and cross-cutting components of an MHEWS, the perspective highlights a mismatch between current ambitions and realities on the ground. Drawing on extensive experience from Practical Action, we identify opportunities to move towards MHEWS through outlining potential entry points in research, policy, and practice. We emphasise a need for localised, inclusive strategies that genuinely address the needs of the most vulnerable populations and fully encompass the meaning of multi-hazards, including hazard interrelationships, the dynamics of risk components, and the complexity of multi-hazard impacts.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112353"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deciphering pre-existing and induced 3D genome architecture changes involved in constricted melanoma migration

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112346

Christopher Playter , Rosela Golloshi , Joshua H. Garretson , Alvaro Rodriguez Gonzalez , Taiwo Habeeb Olajide , Ahmed Saad , Samuel John Benson , Rachel Patton McCord

{"title":"Deciphering pre-existing and induced 3D genome architecture changes involved in constricted melanoma migration","authors":"Christopher Playter , Rosela Golloshi , Joshua H. Garretson , Alvaro Rodriguez Gonzalez , Taiwo Habeeb Olajide , Ahmed Saad , Samuel John Benson , Rachel Patton McCord","doi":"10.1016/j.isci.2025.112346","DOIUrl":"10.1016/j.isci.2025.112346","url":null,"abstract":"<div><div>Metastatic cancer cells traverse constricted spaces that exert forces on their nucleus and the genomic contents within. Cancerous tumors are highly heterogeneous and not all cells within them can achieve such a feat. Here, we investigated what initial genome architecture characteristics favor the constricted migratory ability of cancer cells and which arise only after passage through multiple constrictions. We identified a cell surface protein (ITGB4) whose expression correlates with increased initial constricted migration ability in human melanoma A375 cells. Sorting out this subpopulation allowed us to identify cellular and nuclear features that pre-exist and favor migration, as well as alterations that only appear after cells have passed through constrictions. We identified specific genomic regions that experienced altered genome spatial compartment profiles only after constricted migration. Our study reveals 3D genome structure contributions to both selection and induction mechanisms of cell fate change during cancer metastasis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112346"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of function of Atrx recapitulates phenotypes of alternative lengthening of telomeres in a primary mouse model of sarcoma

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112357

Matthew Pierpoint , Warren Floyd , Amy J. Wisdom , Lixia Luo , Yan Ma , Brendan C. Dickson , Matthew S. Waitkus , David G. Kirsch

{"title":"Loss of function of Atrx recapitulates phenotypes of alternative lengthening of telomeres in a primary mouse model of sarcoma","authors":"Matthew Pierpoint , Warren Floyd , Amy J. Wisdom , Lixia Luo , Yan Ma , Brendan C. Dickson , Matthew S. Waitkus , David G. Kirsch","doi":"10.1016/j.isci.2025.112357","DOIUrl":"10.1016/j.isci.2025.112357","url":null,"abstract":"<div><div>The development of a telomere maintenance mechanism is essential for immortalization in human cancer. While most cancers elongate their telomeres by expression of telomerase, 10–15% of human cancers utilize a pathway known as alternative lengthening of telomeres (ALT). ALT is commonly associated with loss-of-function mutations in ATRX. Here, we developed a genetically engineered primary mouse model of sarcoma in CAST/EiJ mice to investigate the extent to which telomerase deficiency and Atrx-inactivation lead to ALT induction. We observed increases in multiple ALT-associated phenotypic indicators in tumors with loss of function mutations of <em>Atrx.</em> Furthermore, we found that loss of <em>Atrx</em> leads to an increase in telomeric instability and telomere sister chromatid exchange. However, Atrx-deficient tumors did not show productive telomere length maintenance in the absence of telomerase. This primary mouse model of sarcoma could facilitate future investigations into the molecular features of ALT <em>in vivo</em>.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112357"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112347

Yangsong Xu , Man K.S. Lee , Nicole A. de Weerd , Ziyue Fu , Camilla Bertuzzo Veiga , Dragana Dragoljevic , Dmitri Sviridov , Paul J. Hertzog , Andrew J. Fleetwood , Andrew J. Murphy

{"title":"Type I interferon signaling controls the early hematopoietic expansion in response to β-glucan","authors":"Yangsong Xu , Man K.S. Lee , Nicole A. de Weerd , Ziyue Fu , Camilla Bertuzzo Veiga , Dragana Dragoljevic , Dmitri Sviridov , Paul J. Hertzog , Andrew J. Fleetwood , Andrew J. Murphy","doi":"10.1016/j.isci.2025.112347","DOIUrl":"10.1016/j.isci.2025.112347","url":null,"abstract":"<div><div>Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to β-glucan and can profoundly impact hematopoietic stem cell (HSC) function, we hypothesized that this pathway may be involved in the early bone marrow response to β-glucan. <em>In vivo</em> administration of β-glucan led to local interferon-α production in the peritoneal cavity and bone marrow, upregulation of its receptor, IFNAR1, specifically on long-term hematopoietic stem cells (LT-HSCs), and broad expansion of downstream progenitor subpopulations. We demonstrate that intact type I interferon signaling is critical for β-glucan-mediated LT-HSC proliferation, mitochondrial activity, and glycolytic commitment. By determining that type I interferon signaling is important for LT-HSCs, which sit at the apex of the hematopoietic hierarchy, we uncover an important component of the early inflammatory response to β-glucan.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112347"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary learning in neural networks by heterosynaptic plasticity

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112340

Zedong Bi , Ruiqi Fu , Guozhang Chen , Dongping Yang , Yu Zhou , Liang Tian

{"title":"Evolutionary learning in neural networks by heterosynaptic plasticity","authors":"Zedong Bi , Ruiqi Fu , Guozhang Chen , Dongping Yang , Yu Zhou , Liang Tian","doi":"10.1016/j.isci.2025.112340","DOIUrl":"10.1016/j.isci.2025.112340","url":null,"abstract":"<div><div>Training biophysical neuron models provides insights into brain circuits’ organization and problem-solving capabilities. Traditional training methods like backpropagation face challenges with complex models due to instability and gradient issues. We explore evolutionary algorithms (EAs) combined with heterosynaptic plasticity as a gradient-free alternative. Our EA models agents with distinct neuron information routes, evaluated via alternating gating, and guided by dopamine-driven plasticity. This model draws inspiration from various biological mechanisms, such as dopamine function, dendritic spine meta-plasticity, memory replay, and cooperative synaptic plasticity within dendritic neighborhoods. Neural networks trained with this model recapitulate brain-like dynamics during cognition. Our method effectively trains spiking and analog neural networks in both feedforward and recurrent architectures, it also achieves performance in tasks like MNIST classification and Atari games comparable to gradient-based methods. Overall, this research extends training approaches for biophysical neuron models, offering a robust alternative to traditional algorithms.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112340"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passive human touch cannot recognize the shape of a pattern imprinted on the fingertip

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112331

Scinob Kuroki (黒木忍) , Takumi Hamazaki (浜崎拓海) , Hiroyuki Kajimoto (梶本裕之) , Shin’ya Nishida (西田眞也)

{"title":"Passive human touch cannot recognize the shape of a pattern imprinted on the fingertip","authors":"Scinob Kuroki (黒木忍) , Takumi Hamazaki (浜崎拓海) , Hiroyuki Kajimoto (梶本裕之) , Shin’ya Nishida (西田眞也)","doi":"10.1016/j.isci.2025.112331","DOIUrl":"10.1016/j.isci.2025.112331","url":null,"abstract":"<div><div>While tactile spatial pattern recognition has been suggested to be qualitatively similar to visual recognition, our study challenges this notion, particularly under passive touch. Previous electrophysiological and behavioral research suggested that the tactile system can process complex spatial patterns in the same way as the visual system and can be modeled as a low-pass version of visual spatial perception. However, we found that when using energy-matched simple patterns, participants were highly dependent on local skin deformation and largely ineffective at distinguishing basic shape features, such as a closed triangle vs. an open arrow, or to discern the similarity of rotated versions of the same shape, regardless of whether they were presented as vibrotactile patterns or braille patterns. This study provides compelling evidence that tactile representation of spatial patterns differs not only in resolution but also in how the brain processes shape features compared to visual representation in standard passive viewing.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112331"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling hepatic steatosis with human adult stem cell-derived liver organoids

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-03 DOI: 10.1016/j.isci.2025.112344

Liuyang Zhu , Sen Liu , Ze Wang , Yueyue Yang , Pinsheng Han , Wen Tong , Tianyu Zhao , Libo Wang , Tao Cui , Long Yang , Yamin Zhang

{"title":"Modeling hepatic steatosis with human adult stem cell-derived liver organoids","authors":"Liuyang Zhu , Sen Liu , Ze Wang , Yueyue Yang , Pinsheng Han , Wen Tong , Tianyu Zhao , Libo Wang , Tao Cui , Long Yang , Yamin Zhang","doi":"10.1016/j.isci.2025.112344","DOIUrl":"10.1016/j.isci.2025.112344","url":null,"abstract":"<div><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) remains the most common chronic liver disease worldwide, and appropriate <em>in vitro</em> models are of great significance for investigating pathogenesis and drug screening of MASLD. In this study, human expandable cholangiocyte organoids were derived from adult stem cells of normal liver tissue. After differentiation, liver organoids (LOs) exhibited the functional characteristics and genomic features of mature hepatocytes. To induce steatosis, LOs were incubated with a gradient concentration oleic acid, and it was found that the model could recapitulate the development of lipid accumulation and inflammation. In addition, the drug sensitivity of the hepatic steatosis model was further verified through anti-steatosis drug testing. In summary, LOs have great potential for disease modeling, and the results indicate that the hepatic steatosis model may serve as a useful tool for exploring the molecular mechanisms and drug screening of MASLD.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112344"},"PeriodicalIF":4.6,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143828314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0