iScience最新文献_第10页

Is there progress in the adsorbent development for water treatment? 水处理吸附剂的发展有什么进展吗？

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-26 DOI: 10.1016/j.isci.2025.112993

Tero Luukkonen , Juhani Teeriniemi

引用次数: 0

Inhibiting ANP32E protects against acute kidney injury by regulating autophagy via the AMPK pathway 抑制ANP32E可通过AMPK途径调节自噬，从而预防急性肾损伤

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-26 DOI: 10.1016/j.isci.2025.113014

Chunjie Wang , Fang Bai , Luyao Li , Kuipeng Yu , Xiangdong Yang

引用次数: 0

Cardiac fibrosis inhibitor CTPR390 prevents structural and morphological changes in human engineered cardiac connective tissue 心脏纤维化抑制剂CTPR390阻止人类工程心脏结缔组织的结构和形态变化

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-26 DOI: 10.1016/j.isci.2025.113013

David Maestro , Ana Palanca , Helena Soto , I. Llarena , Alisa Nicole DeGrave , Gabriela Guedes , Guilherme Henrique de Oliveira , André Luiz Coelho Conceição , Verónica Mieites , Jose M. Icardo , Carlos Sanchez-Cano , Olga M. Conde , Susanne Lutz , Aitziber L. Cortajarena , Ana V. Villar

{"title":"Cardiac fibrosis inhibitor CTPR390 prevents structural and morphological changes in human engineered cardiac connective tissue","authors":"David Maestro , Ana Palanca , Helena Soto , I. Llarena , Alisa Nicole DeGrave , Gabriela Guedes , Guilherme Henrique de Oliveira , André Luiz Coelho Conceição , Verónica Mieites , Jose M. Icardo , Carlos Sanchez-Cano , Olga M. Conde , Susanne Lutz , Aitziber L. Cortajarena , Ana V. Villar","doi":"10.1016/j.isci.2025.113013","DOIUrl":"10.1016/j.isci.2025.113013","url":null,"abstract":"<div><div>Cardiac fibrosis is a key characteristic of heart failure. CTPR390, an experimental anti-fibrotic inhibitor targeting Hsp90, has shown success in animal models, but remains unexplored in human cardiac models. This study evaluated an engineered cardiac connective tissue (ECCT) model, focusing on changes in the extracellular matrix and fibroblasts. Results showed that CTPR390 prevented architectural changes in TGFβ1-activated ECCT, preserving tissue perimeter, collagen fibers alignment while reducing structured areas and degree of collagen structuration. CTPR390 treatment reduced cell area of fibroblasts under tension, without changes in the internal rounded cells devoid of tension. Fibroblast recruitment to tension areas was diminished, showing biomechanical behavior similar to control ECCT. This treatment also lowered the gene and protein expression of key pro-fibrotic markers. Here, advanced biotechnology was employed to detect the detailed structure of tissue fibrosis reduction after administering CTPR390, representing a significant advancement toward clinical application for cardiac fibrosis treatment.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 8","pages":"Article 113013"},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating millet biochar as mitigator of pesticide toxicity in soil using biomarkers 利用生物标志物评价谷子生物炭对土壤农药毒性的缓解作用

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-26 DOI: 10.1016/j.isci.2025.112991

Pradip Kumar Jena , Suryasikha Samal , Rashmi Rekha Samal , Soumya Ranjan Panigrahi , Urmila Baral , Subhalaxmi Behera , Jayanta Kumar Biswas , C.S.K. Mishra

{"title":"Evaluating millet biochar as mitigator of pesticide toxicity in soil using biomarkers","authors":"Pradip Kumar Jena , Suryasikha Samal , Rashmi Rekha Samal , Soumya Ranjan Panigrahi , Urmila Baral , Subhalaxmi Behera , Jayanta Kumar Biswas , C.S.K. Mishra","doi":"10.1016/j.isci.2025.112991","DOIUrl":"10.1016/j.isci.2025.112991","url":null,"abstract":"<div><div>Pesticide buildup in agricultural soils disrupts ecosystem function by harming soil biota and microbial activity. This study evaluates biochar derived from finger millet biomass as a remediation agent for pesticide contaminated soil. Characterization of the biochar using XRD, SEM, FTIR, and GC-MS revealed a porous structure suitable for adsorbing organic pollutants. Molecular docking showed strong interactions between biochar and the pesticides, dimethoate, and pretilachlor. Biochar application in contaminated soil enhanced total protein content and reduced lipid peroxidation, lactate dehydrogenase (LDH), and catalase (CAT) activities in the earthworm (<em>Eisenia fetida</em>) tissue. Activities of soil exoenzymes: amylase, invertase, and cellulase increased in response to biochar amendment, indicating improved microbial function. These findings suggest that finger millet biochar effectively lowers pesticide toxicity while supporting soil biological recovery, offering a sustainable approach in maintaining soil health.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 8","pages":"Article 112991"},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144605200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive environmental assessment of typical Chinese industrial metal production processes 中国典型工业金属生产工艺的综合环境评价

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-26 DOI: 10.1016/j.isci.2025.113011

Zhaolong Wang , Han Cui , Wenyi Yan , Guangming Zhang , Pengfei Wang , Xiaoyang Liu , Zhijun Ren , Zhi Sun , Wenfang Gao

{"title":"Comprehensive environmental assessment of typical Chinese industrial metal production processes","authors":"Zhaolong Wang , Han Cui , Wenyi Yan , Guangming Zhang , Pengfei Wang , Xiaoyang Liu , Zhijun Ren , Zhi Sun , Wenfang Gao","doi":"10.1016/j.isci.2025.113011","DOIUrl":"10.1016/j.isci.2025.113011","url":null,"abstract":"<div><div>To promote energy conservation and emission reduction, a quantitative assessment of pollutants from metal production is imperative. However, conventional life cycle assessment cannot provide detail environmental impact assessment for pollutants (e.g., waste water, waste gas, and solid waste) in metal productions. In this research, by analyzing 39 kinds of pollutants, a comprehensive environmental assessment (CEA) was conducted for 31 kinds of typical industrial metal-production processes in China. For CEA, Li, In, Cr, K, and Hg have higher environmental impact. Under global warming potential (GWP), 5 metals with higher carbon emission impacts are as follows: Nb > Ta > Mo > Cr > Au. A comprehensive analysis of CEA and GWP revealed that Cr has the most severe environmental impact (CEA: 74.99; GWP: 48500 kg CO<sub>2</sub> eq./kg), while Ca exhibits the minimal influence (CEA: 0.05; GWP: 1.02 kg CO<sub>2</sub> eq./kg). Overall, this research offers valuable insights to optimize relevant production processes.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 8","pages":"Article 113011"},"PeriodicalIF":4.6,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep-learning based colorectal cancer pathological analysis with hyperspectral light field microscopy 基于深度学习的高光谱光场显微镜结直肠癌病理分析

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-25 DOI: 10.1016/j.isci.2025.112987

Hao Sheng , Yingying Zhang , Ruixuan Cong , Shuai Wang , Da Yang , Zhenglong Cui , Xuefei Huang , Rongshan Chen , Jiapeng Liu , Wei Ke , Weifeng Lv

{"title":"Deep-learning based colorectal cancer pathological analysis with hyperspectral light field microscopy","authors":"Hao Sheng , Yingying Zhang , Ruixuan Cong , Shuai Wang , Da Yang , Zhenglong Cui , Xuefei Huang , Rongshan Chen , Jiapeng Liu , Wei Ke , Weifeng Lv","doi":"10.1016/j.isci.2025.112987","DOIUrl":"10.1016/j.isci.2025.112987","url":null,"abstract":"<div><div>5D hyperspectral light field (H-LF) integrates multi-angular and multi-spectral observation, offering a comprehensive opportunity to capture more detailed information from biological samples. In this article, we integrate hyperspectral light field microscopy imaging to analyze H&E-stained whole slide images (WSIs) of colorectal cancer (CRC). Specifically, we design a triple separable transformer encoder (HLFTST) that efficiently extracts features by decoupling the 5D H-LF data into lower-dimensional components and applying self-attention for global interaction. We also introduce a text encoder-decoder to align H-LF features with language, enabling automatic cell classification and pathology report generation through a three-stage training pipeline. Experiments show our method outperforms 2D, 3D, and 4D baselines, improving precision by up to 4.88% and F1 score by 4.21% across five CRC cell categories. Additionally, it generates meaningful pathology descriptions, highlighting its potential for enhancing diagnostics and supporting personalized treatment in broader biomedical settings.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 8","pages":"Article 112987"},"PeriodicalIF":4.6,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Industry 4.0 enabled calorimetry and heat transfer for renewable energy systems 工业4.0为可再生能源系统实现了量热和传热

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-25 DOI: 10.1016/j.isci.2025.112994

Emmanuel O. Atofarati , Christopher C. Enweremadu

引用次数: 0

The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice 小鼠后囊中央杏仁核显示与伤害性疼痛相关的臂旁神经元突触共激活

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-06-25 DOI: 10.1016/j.isci.2025.113001

Takao Okuda , Sawako Uchiyama , Naoko Sato , Yae K. Sugimura , Yukari Takahashi , Makoto Tsuda , Fusao Kato

{"title":"The posterior capsular central amygdala showing synaptic coactivation with nociplastic pain-associated parabrachial neurons in mice","authors":"Takao Okuda , Sawako Uchiyama , Naoko Sato , Yae K. Sugimura , Yukari Takahashi , Makoto Tsuda , Fusao Kato","doi":"10.1016/j.isci.2025.113001","DOIUrl":"10.1016/j.isci.2025.113001","url":null,"abstract":"<div><div>Projections from the external lateral parabrachial nucleus (elPB) to the central amygdala (CeA) are a key pathway for nociceptive signals and play a crucial role in establishing nociplastic pain sensitization, a state of heightened pain without nociceptor activation or nerve injury. To investigate their roles in nociplastic pain, we aimed to analyze how pain-activated elPB neurons transmit information to pain-activated CeA neurons. Using transgenic TRAP2 mice that underwent transient localized inflammation, we selectively expressed marker proteins, light-sensitive channels, and chemogenetic receptors in pain-activated neurons. We found that the pain-activated (“nociTRAPed”) neurons in the elPB project extensively to the CeA, particularly to the caudal half of the capsular CeA (defined as “posterior CeC” or pCeC), where they form robust functional connections with nociTRAPed pCeC neurons, promoting nociplastic sensitization. We propose that the pCeC serves as the site of direct co-activation with pain-activated elPB neurons, translating peripheral nociceptive information into CeA excitation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 8","pages":"Article 113001"},"PeriodicalIF":4.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144721595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Graded remapping of prefrontal representations preserves a cumulative record of distinct events within an environment 前额叶表征的分级重新映射保留了环境中不同事件的累积记录

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-25 DOI: 10.1016/j.isci.2025.113009

Yangzi Chen , Gaqi Tu , Lizhe Zhang , Kaori Takehara-Nishiuchi

引用次数: 0

Spatiotemporal analysis of atmospheric aerosols in African environments using MERRA-2 data (1980–2024): Impacts on climate extremes 利用MERRA-2数据的非洲大气气溶胶时空分析（1980-2024）：对极端气候的影响

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-25 DOI: 10.1016/j.isci.2025.112995

Daniel O. Omokpariola

引用次数: 0