iScience最新文献_第10页

Dual CO₂ mitigations with diminishing margins: Evidence from China's intensity-based national emissions trading scheme. 边际递减的双重CO2减缓：来自中国基于强度的国家排放交易计划的证据。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115424

Chen Lyu, Ke Wang, Bofeng Cai, Yujiao Xian

{"title":"Dual CO<sub>2</sub> mitigations with diminishing margins: Evidence from China's intensity-based national emissions trading scheme.","authors":"Chen Lyu, Ke Wang, Bofeng Cai, Yujiao Xian","doi":"10.1016/j.isci.2026.115424","DOIUrl":"10.1016/j.isci.2026.115424","url":null,"abstract":"<p><p>China's national emissions trading scheme (CN ETS) is the world's largest carbon market in terms of covered emissions, yet rigorous empirical evidence on its mitigation effectiveness remains limited. Using a balanced panel of 1,957 thermal power units from 2018 to 2024, this study estimates the causal impacts of compliance pressure under the CN ETS on CO<sub>2</sub> emissions. Units with allowance deficits reduced CO<sub>2</sub> emission intensity by 0.8% and total emissions by 3.5%. Emission reductions are concentrated among small coal-fired units and are driven by efficiency improvements, higher heat supply ratios, and improved fuel quality. In contrast, the impacts on large coal-fired units are limited. Greater intensity reductions are observed among local state-owned and private firms, captive plants, non-pilot units, and technologically less advanced units. Overall, the intensity-based design provides limited incentives to curb output among low-emission-intensity units, suggesting the intensity-based mechanism functions as a transitional arrangement toward a cap-and-trade system.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115424"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-cohort and single-cell profiling of aging genes reveals prognostic and therapeutic targets in breast cancer 衰老基因的多队列和单细胞分析揭示了乳腺癌的预后和治疗靶点

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114847

Li Huang , Lei Zhang , Xiaoyu Shi , Chun Wang , Xin Chen , Miao Li , Ni Ni , Ge Gao , Tao Wang , Xiaonan Zhang

{"title":"Multi-cohort and single-cell profiling of aging genes reveals prognostic and therapeutic targets in breast cancer","authors":"Li Huang , Lei Zhang , Xiaoyu Shi , Chun Wang , Xin Chen , Miao Li , Ni Ni , Ge Gao , Tao Wang , Xiaonan Zhang","doi":"10.1016/j.isci.2026.114847","DOIUrl":"10.1016/j.isci.2026.114847","url":null,"abstract":"<div><div>Aging-related transcriptional programs shape breast cancer progression, immune regulation, and therapeutic response. We integrated curated aging-associated genes with 108 survival modeling strategies to derive a machine learning-based aging gene signature. Trained in the TCGA-BRCA cohort and evaluated across twelve independent datasets, the eight-gene MLAG score consistently stratified patients by survival risk across clinical contexts. High MLAG exhibited increased genomic instability, including elevated tumor mutational burden and copy number alterations, together with distinct regulatory and intercellular communication patterns. In contrast, low MLAG showed enhanced immune infiltration, coordinated microenvironment signaling, and higher immune checkpoint expression. Integration of bulk and single-cell transcriptomic analyses localized MLAG-associated aging programs primarily to malignant epithelial cells and linked them to aneuploidy and stress-response pathways. The MLAG score associated with immune checkpoint blockade response and supported identification of candidate therapeutic strategies. These findings highlight the relevance of aging-associated transcriptional states in breast cancer prognosis and treatment stratification.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114847"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD 机器学习驱动的COPD、NSCLC和NSCLC合并COPD的共享和疾病特异性线粒体相关基因鉴定

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114857

Siyu Wu , Zelin Chen , Tongxinwei Sun , Beibei Song , Xinxiu Liu , Liwen Zhang , Jing Li , Haoran Lu , Wenhui Song , Aihong Meng

{"title":"Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD","authors":"Siyu Wu , Zelin Chen , Tongxinwei Sun , Beibei Song , Xinxiu Liu , Liwen Zhang , Jing Li , Haoran Lu , Wenhui Song , Aihong Meng","doi":"10.1016/j.isci.2026.114857","DOIUrl":"10.1016/j.isci.2026.114857","url":null,"abstract":"<div><div>Chronic obstructive pulmonary disease (COPD) and non-small-cell lung cancer (NSCLC) often coexist; here, the shared mitochondrial drivers were investigated. Serum from 30 subjects (seven controls, nine COPD, eight NSCLC, and six NSCLC with COPD) underwent RNA-seq, integrated with 1,136 MitoCarta 3.0-derived mitochondrial-related genes (MRGs). DESeq2 identified 25, 124, and 58 mitochondria-related differentially expressed genes (MR-DEGs) in COPD, NSCLC, and their comorbidity, respectively, with 15 and 58 overlapping genes in relevant pairs. SVM-RFE selected two biomarker sets (3-gene and 5-gene), showing excellent diagnostic performance via ROC (AUC 0.89–0.92) and accurate multivariate logistic regression models. GSEA highlighted immune-inflammatory and oxidative phosphorylation pathways; CIBERSORT revealed altered immune cell proportions (e.g., elevated monocytes in COPD) with biomarker-immune cell correlations. CTD linked <em>BID/COX7A2</em> to NSCLC, and DGIdb identified metformin/ME-344 as potential drugs. These mitochondrial gene signatures, validated in blood as robust classifiers of COPD, NSCLC, and their overlap, simultaneously furnish diagnostic biomarkers and actionable therapeutic targets, underscoring the translational value of mitochondria-immune crosstalk.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114857"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Much higher covariation with foveation timing by superior colliculus than primary visual cortical neuronal activity. 与初级视觉皮层神经元活动相比，上丘与注视点时间的共变要高得多。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115432

Carlotta Trottenberg, Yue Yu, Tong Zhang, Matthias P Baumann, Tatiana Malevich, Shweta Prasad, Ziad M Hafed

{"title":"Much higher covariation with foveation timing by superior colliculus than primary visual cortical neuronal activity.","authors":"Carlotta Trottenberg, Yue Yu, Tong Zhang, Matthias P Baumann, Tatiana Malevich, Shweta Prasad, Ziad M Hafed","doi":"10.1016/j.isci.2026.115432","DOIUrl":"https://doi.org/10.1016/j.isci.2026.115432","url":null,"abstract":"<p><p>The superior colliculus (SC) is a potent driver for orienting movements, but it also possesses short-latency visual responses. Even though such responses largely derive from direct primary visual cortical (V1) input, their relationship to V1 activity has never been analyzed with the same experimental subjects and stimuli. Here, we revisited pioneering observations that trial-by-trial variability in either SC or V1 visual responses may predict eye movement timing variability. We found that V1 covariation with behavioral variability was virtually non-existent in comparison to the SC, whether with respect to visual response onset latency, visual response strength, or pre-stimulus state. By far, our largest predictor of behavioral variability was visual response strength in SC visual-motor neurons. These results suggest that the SC reformats its sensory inputs for exploitation of the SC's proximity to the motor periphery; V1 aids in jumpstarting the sensing process, but the SC much more directly supports visually driven orienting.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115432"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13084408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive analysis of neutrophil immunomodulatory properties and FcR dynamics in HIV-1 infection and therapy. HIV-1感染和治疗中中性粒细胞免疫调节特性和FcR动力学的综合分析。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115431

Soledad Marsile-Medun, Manon Souchard, Daouda Abba Moussa, Valérie Lorin, Hugo Mouquet, Elisa Reynaud, Rayane Dibsy, Edouard Tuaillon, Delphine Muriaux, Giang Ngo, Martine Pugnière, Mar Naranjo-Gomez, Mireia Pelegrin

{"title":"Comprehensive analysis of neutrophil immunomodulatory properties and FcR dynamics in HIV-1 infection and therapy.","authors":"Soledad Marsile-Medun, Manon Souchard, Daouda Abba Moussa, Valérie Lorin, Hugo Mouquet, Elisa Reynaud, Rayane Dibsy, Edouard Tuaillon, Delphine Muriaux, Giang Ngo, Martine Pugnière, Mar Naranjo-Gomez, Mireia Pelegrin","doi":"10.1016/j.isci.2026.115431","DOIUrl":"10.1016/j.isci.2026.115431","url":null,"abstract":"<p><p>Neutrophils are innate immune cells with immunomodulatory functions. Using a murine retroviral model, we previously demonstrated their role in promoting protective immunity during antibody therapy through Fc-Fcγ receptor (FcγR) interactions. Here, we investigated neutrophil activation and FcγR regulation in the context of HIV-1 infection and antibody-based therapies. Neutrophils from healthy donors (HD) and people living with HIV-1 (PLWH) were stimulated with TLR ligands, free HIV-1, immune complexes (ICs) formed with broadly neutralizing antibodies (bNAbs), or pro-inflammatory cytokines. Neutrophils displayed stimulus-dependent cytokine and chemokine responses. HD neutrophils showed limited activation and FcγR modulation in response to free HIV-1 or IC compared with TLR agonists or cytokines. Conversely, PLWH neutrophils exhibited heightened responsiveness to HIV-associated stimuli, with increased secretion of IFNγ, CXCL1, CCL2, CCL3, and CCL4, along with elevated expression of activating FcγRs and activation markers. These findings highlight the influence of the inflammatory milieu on neutrophil function and FcγR regulation during HIV-1 infection.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115431"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147727906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extreme heat exacerbates atmospheric ozone pollution: Holistic data-based causal investigation in China 极端高温加剧了中国大气臭氧污染：基于数据的整体因果调查

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114854

Ruixun Xia , Qi Qi , Jiyuan Yang , Bailiang Li , Yaoqi Li , Andrew P. Morse , Tenglong Li , Qing Mu

{"title":"Extreme heat exacerbates atmospheric ozone pollution: Holistic data-based causal investigation in China","authors":"Ruixun Xia , Qi Qi , Jiyuan Yang , Bailiang Li , Yaoqi Li , Andrew P. Morse , Tenglong Li , Qing Mu","doi":"10.1016/j.isci.2026.114854","DOIUrl":"10.1016/j.isci.2026.114854","url":null,"abstract":"<div><div>Climate change-induced extreme heat (EH) events intensify atmospheric surface ozone (O<sub>3</sub>) pollution, posing growing threats to public health and environment. To address the lack of rigorous empirical confirmation regarding the causal impact of EH on O<sub>3</sub> despite their observed co-occurrence, this study develops a robust statistical framework to assess this relationship across China. The framework integrates three checkpoints: (1) correlational checkpoint based on linear mixed model; (2) causal checkpoint based on instrumental variable, Heckman two-step selection model, and propensity score methods with generalized bootstrap validation; and (3) directional (of causality) checkpoint based on transfer entropy. Results consistently demonstrate a statistically significant causal effect of EH on elevated O<sub>3</sub> levels, with the dominant influence flowing from EH to O<sub>3</sub> nationwide and across most provinces in China. These findings support integrated air quality management and climate adaptation strategies, guiding policy interventions to mitigate the compound risks of EH and O<sub>3</sub> pollution.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114854"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FXR in bone metabolism: An emerging regulator 骨代谢中的FXR：一个新兴的调节因子

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114842

S. M. Mahamudul Hassan Rizvi , Aihemaiti Shami , Yun Kan , Shengxiang Tao , Hui Liu

{"title":"FXR in bone metabolism: An emerging regulator","authors":"S. M. Mahamudul Hassan Rizvi , Aihemaiti Shami , Yun Kan , Shengxiang Tao , Hui Liu","doi":"10.1016/j.isci.2026.114842","DOIUrl":"10.1016/j.isci.2026.114842","url":null,"abstract":"<div><div>Farnesoid X receptor (FXR), a core regulator of bile acid metabolism, is also a key modulator of bone metabolism that influences bone remodeling by regulating osteoblast and osteoclast activities. FXR activation promotes the proliferation and differentiation of osteoblasts via pathways such as Wnt/β-catenin, and inhibits osteoclastogenesis through the NF-κB pathway and the RANK/OPG balance. It also regulates chondrocyte function and cartilage integrity, inhibits cartilage-degrading MMP-13, coordinates subchondral bone remodeling to maintain joint health, and acts as a metabolic hub linking the gut, liver, and bone by integrating bile acid and systemic metabolic signals. Dysregulation of this pathway is associated with skeletal complications of non-alcoholic fatty liver disease (NAFLD), obesity and other disorders, and intestinal FXR-mediated FGF15/19 signaling also maintains skeletal homeostasis. FXR activation is a promising therapeutic target for preserving bone density by improving metabolism and alleviating inflammation. This review elucidates its regulatory mechanisms in bone metabolism, laying a foundation for relevant research and translational applications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114842"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing. 鼻内复制腺病毒4型载体SARS-CoV-2疫苗在临床前试验中诱导持久有效的反应。

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115433

Breanna Kim, Rachel Roenicke, Peyton M Roeder, Isabel Steinberg, Andy Patamawenu, Mitra Harrison, Freya Van't Veer, Emma Koory, Jane Xie, Tulley Shofner, Kenta Matsuda, Eleanor Wettstein, Ellison Ober, Ceanna Cooney, Tae Kim, Jonathan D Webber, Tyler Meeks, Chung Park, Tracey Burdette, Shalamar Georgia, James M Readler, Alexander C Vostal, Anna Hostal, Jeffrey I Cohen, Matthew Gagne, Zohar Ziff, Ketan Richard, Matthew R Burnett, Erin Maule, Viviane Callier, Jason Liang, Gabriela Kovacikova, Scarlett C Souter, Joshua A Weiner, Daniel Douek, Margaret E Ackerman, Peter F Wright, Reed F Johnson, Mark Connors

{"title":"Intranasal replicating adenovirus type 4-vectored SARS-CoV-2 vaccines induce durable and efficacious responses in preclinical testing.","authors":"Breanna Kim, Rachel Roenicke, Peyton M Roeder, Isabel Steinberg, Andy Patamawenu, Mitra Harrison, Freya Van't Veer, Emma Koory, Jane Xie, Tulley Shofner, Kenta Matsuda, Eleanor Wettstein, Ellison Ober, Ceanna Cooney, Tae Kim, Jonathan D Webber, Tyler Meeks, Chung Park, Tracey Burdette, Shalamar Georgia, James M Readler, Alexander C Vostal, Anna Hostal, Jeffrey I Cohen, Matthew Gagne, Zohar Ziff, Ketan Richard, Matthew R Burnett, Erin Maule, Viviane Callier, Jason Liang, Gabriela Kovacikova, Scarlett C Souter, Joshua A Weiner, Daniel Douek, Margaret E Ackerman, Peter F Wright, Reed F Johnson, Mark Connors","doi":"10.1016/j.isci.2026.115433","DOIUrl":"10.1016/j.isci.2026.115433","url":null,"abstract":"<p><p>The portfolio of next-generation COVID-19 vaccines would benefit from candidates that induce durable systemic and mucosal immune responses that would lessen person-to-person transmission. We constructed an intranasal (IN) replication-competent adenovirus type 4 recombinant platform to express SARS-CoV-2 spike variants (Ad4-S) and assessed immunogenicity and efficacy in the Syrian hamster model. Although both IN Ad4-S and intramuscular (IM) vaccines (Ad26.CoV2.S and mRNA-1273) induced serum binding antibodies, only Ad4-S induced a robust nasal mucosal response. IN Ad4-S vaccination induced serum neutralizing titers equivalent to or greater than IM vaccination but more durable up to 6 months. Upon challenge, IN immunization also resulted in less weight loss, greater breadth and durability of restriction of viral replication, and less lung pathology than IM immunization up to 268 days after immunization. These data support the potential of the IN Ad4 vaccine platform to reduce the transmission of SARS-CoV-2 and other respiratory viruses with pandemic potential.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 4","pages":"115433"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13090634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient bioimaging using rare-earth-doped carbon quantum dots: A doping strategy 使用稀土掺杂碳量子点的高效生物成像：掺杂策略

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-02 DOI: 10.1016/j.isci.2026.114869

Junyang Shao , Yi Zhang , Chaoyu He , Jiarui Luo , Shang Wu , Zhiyong Bei , Yaoting Wang , Ling Zhang , Han Wu , Liang Jin

{"title":"Efficient bioimaging using rare-earth-doped carbon quantum dots: A doping strategy","authors":"Junyang Shao , Yi Zhang , Chaoyu He , Jiarui Luo , Shang Wu , Zhiyong Bei , Yaoting Wang , Ling Zhang , Han Wu , Liang Jin","doi":"10.1016/j.isci.2026.114869","DOIUrl":"10.1016/j.isci.2026.114869","url":null,"abstract":"<div><div>This study addressed the limitations of carbon quantum dots (CQDs) in bioimaging, specifically low photoluminescence quantum yield (PLQY) and complex purification processes, by developing lanthanide-doped CQDs (L-CQDs). Using a microwave-assisted solvothermal method in a glycerol-water system with precursor mass ratios of citric acid monohydrate: urea: NdCl<sub>3</sub>·6H<sub>2</sub>O:CeCl<sub>3</sub> at 30:3:10:2 and a glycerol/water volume ratio of 2:1, we achieved one-pot synthesis with cerium and neodymium doping. This approach significantly enhanced the PLQY from 0.43% to 69%. The resulting L-CQDs exhibited a graphene-like structure (≈8 nm) and demonstrated anti-Stokes blue emission under 740 and 800 nm excitation. Besides, ethanol precipitation facilitated purification and indicated surface hydrophobicity post-doping. The materials showed excellent biosafety in HUVEC cells, RAW264.7 cells, and C57 mice, with enhanced fluorescence intensity and specific accumulation in highly perfused organs, including the brain, lungs, spleen, and kidneys, while demonstrating blood-brain barrier penetration capability. These findings highlighted the potential of L-CQDs for cellular labeling and <em>in vivo</em> fluorescence imaging applications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114869"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modification of chitooligosaccharide with phenolic acids for extended cherry tomato preservation and quality retention 酚酸改性壳寡糖对樱桃番茄保鲜期的影响

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-24 DOI: 10.1016/j.isci.2026.114797

Ruyi Zhang , Hui Chen , Ruohui Li , Shuyan Lin , Nan Wang

{"title":"Modification of chitooligosaccharide with phenolic acids for extended cherry tomato preservation and quality retention","authors":"Ruyi Zhang , Hui Chen , Ruohui Li , Shuyan Lin , Nan Wang","doi":"10.1016/j.isci.2026.114797","DOIUrl":"10.1016/j.isci.2026.114797","url":null,"abstract":"<div><div>Coating materials extend fruit shelf life by forming protective barriers against microbial growth and preserving freshness. Herein, three chitooligosaccharide (COS) derivatives were synthesized via grafting protocatechuic acid, caffeic acid, and gallic acid onto COS, with their structures characterized. Fourier transform infrared spectroscopy confirmed successful grafting via amide linkages. <sup>1</sup>H NMR analysis revealed new absorption peaks between 6.5 and 7.5 ppm, attributable to the grafted phenolic acids. Compared to ungrafted COS, the derivatives exhibited enhanced antioxidant activity and superior bacteriostatic activity. Spraying 2 mg L<sup>−1</sup> derivatives on cherry tomatoes significantly reduced decay (33.7%–44.7%), browning (14.3%–23.6%), and the accumulation of reducing sugars (41.9%–49.6%) and soluble solids (13.3%–22.3%) during storage. These derivatives alleviated oxidative stress by enhancing catalase activity and reducing malondialdehyde levels, while inhibiting polyphenol oxidase to slow phenolic degradation and delay senescence. This grafted COS derivative coating offers enhanced biocompatibility for cherry tomato preservation systems.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114797"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0