iScience最新文献_第10页

Advances of 3D bioprinting technology for periodontal tissue regeneration 生物3D打印技术在牙周组织再生中的应用进展

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-25 DOI: 10.1016/j.isci.2025.112532

Huanhuan Chen , Yu Wang , Yue Lai , Chenda Meng , Xiner Ning , Tianmin Xu , Guangying Song , Yunfan Zhang , Yifan Lin , Bing Han

{"title":"Advances of 3D bioprinting technology for periodontal tissue regeneration","authors":"Huanhuan Chen , Yu Wang , Yue Lai , Chenda Meng , Xiner Ning , Tianmin Xu , Guangying Song , Yunfan Zhang , Yifan Lin , Bing Han","doi":"10.1016/j.isci.2025.112532","DOIUrl":"10.1016/j.isci.2025.112532","url":null,"abstract":"<div><div>3D bioprinting technology for periodontal tissue regeneration is an advanced manufacturing technique that utilizes three-dimensional (3D) printing principles to fabricate intricate, viable structures that are specifically devised to meet with the demand for the periodontal regeneration. Personalized tissue substitutes through 3D bioprinting possesses the capability to promote tissue regeneration in tissue-defective regions. However, the current 3D bioprinting for periodontal tissue engineering still is confronted with many huge challenges that include selecting the optimal rheological properties for precise printing, ensuring the biocompatibility, and facilitating the consistent cell incorporation. In this review, we introduced the pathogenesis of periodontitis and the principle and categories of 3D bioprinting technology. We provided a comprehensive overview of the latest advancements in the application of cutting-edge biofabrication technology of 3D bioprinting for the overall periodontal regeneration, aiming to provide valuable insights for the optimization of 3D bioprinting technology and potential directions for future clinical application.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112532"},"PeriodicalIF":4.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neighborhood green space and Diabetes Mellitus in Brazil 巴西社区绿地与糖尿病的关系

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112527

Reizane Maria Damasceno da Silva , João Pedro Rodrigues Pêgo , Mariana Andreotti Dias , Francisco Jablinski Castelhano , Julia Placido Moore , Jun Yang , Weeberb J. Requia

{"title":"Neighborhood green space and Diabetes Mellitus in Brazil","authors":"Reizane Maria Damasceno da Silva , João Pedro Rodrigues Pêgo , Mariana Andreotti Dias , Francisco Jablinski Castelhano , Julia Placido Moore , Jun Yang , Weeberb J. Requia","doi":"10.1016/j.isci.2025.112527","DOIUrl":"10.1016/j.isci.2025.112527","url":null,"abstract":"<div><div>Diabetes Mellitus is a global public health concern, yet its association with neighborhood green space remains unexplored at a national scale in Brazil. This study analyzed the relationship between green space, measured via the Normalized Difference Vegetation Index (NDVI), and diabetes-related hospitalizations from 2008 to 2018. Using quasi-Poisson regression models, we assessed hospitalization data by sex and age group, incorporating air pollution, weather, and socioeconomic factors as covariates. Results showed regional variations: increased greenness was linked to lower hospitalizations in the North and Midwest, while the Northeast and Southeast exhibited higher hospitalization rates with increased NDVI. The South had mixed results, with positive associations for men and middle-aged individuals. Findings suggest green spaces may have a protective effect in some regions but require further investigation in others. These results underscore the need for targeted urban planning and public health strategies to optimize green space benefits.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112527"},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STEAP3 promotes triple-negative breast cancer growth through the FGFR1-mediated activation of PI3K/AKT/mTOR signaling STEAP3通过fgfr1介导的PI3K/AKT/mTOR信号的激活促进三阴性乳腺癌的生长

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112526

Lifang Yuan , Yuhan Bao , Junbao Liu , Ping Sun

引用次数: 0

A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation 肿瘤微血管芯片揭示了癌细胞簇内渗的机制

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112517

Yukinori Ikeda , Makoto Kondo , Jun-ichi Suehiro , Hiroko Oshima , Sau Yee Kok , Kazuki Takahashi , Joris Pauty , Dong Wang , Hiroyuki Sakurai , Tetsuro Watabe , Masanobu Oshima , Yukiko T. Matsunaga

{"title":"A tumor-microvessel on-a-chip reveals a mechanism for cancer cell cluster intravasation","authors":"Yukinori Ikeda , Makoto Kondo , Jun-ichi Suehiro , Hiroko Oshima , Sau Yee Kok , Kazuki Takahashi , Joris Pauty , Dong Wang , Hiroyuki Sakurai , Tetsuro Watabe , Masanobu Oshima , Yukiko T. Matsunaga","doi":"10.1016/j.isci.2025.112517","DOIUrl":"10.1016/j.isci.2025.112517","url":null,"abstract":"<div><div>Circulating tumor cell (CTC) clusters are often detected in blood samples of patients with high-grade tumor and are associated with tumor metastasis and poor prognosis. However, the underlying mechanisms by which cancer cell clusters are released from primary tumors beyond blood vessel barriers remain unclear. In this study, a three-dimensional (3D) <em>in vitro</em> culture system was developed to visualize tumor intravasation by positioning tumor organoids with distinct genetic backgrounds to surround microvessels. We visualized tumor intravasation in a cluster unit, including collective migration toward microvessels, vessel co-option, and the release of CTC clusters—an invasion mechanism not previously reported. Furthermore, elevated levels of transforming growth factor β (TGF-β) and activin expression in endothelial cells within the coculture microenvironment were pivotal for facilitating tumor cell intravasation, which was associated with endothelial-to-mesenchymal transition (EndoMT) in microvessels. Our 3D <em>in vitro</em> system can be used to develop therapeutic strategies for tumor metastasis by targeting the release of CTC clusters.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112517"},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The HDL-transporting scavenger receptor B1 promotes viral infection through endolysosomal acidification 高密度脂蛋白转运清道夫受体B1通过内溶酶体酸化促进病毒感染

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112501

Jill McConnell , Sun-Young Lim , Thomas Cicuto , Ping Liu , Pyae Phyo Kyawe , Manish Kandpal , Evan S. Bradley , Kendi Okuda , Neal Silverman , Jennifer P. Wang , William M. McDougall

{"title":"The HDL-transporting scavenger receptor B1 promotes viral infection through endolysosomal acidification","authors":"Jill McConnell , Sun-Young Lim , Thomas Cicuto , Ping Liu , Pyae Phyo Kyawe , Manish Kandpal , Evan S. Bradley , Kendi Okuda , Neal Silverman , Jennifer P. Wang , William M. McDougall","doi":"10.1016/j.isci.2025.112501","DOIUrl":"10.1016/j.isci.2025.112501","url":null,"abstract":"<div><div>Virus infections pose a continuous threat to human health and can result in millions of deaths per year. SARS-CoV-2 infection has been linked to the high-affinity high-density lipoprotein (HDL) receptor scavenger receptor class B, type 1 (SR-B1). Mechanisms by which SR-B1 supports SARS-CoV-2 infection and replication, as well as the breadth of viruses that exploit this receptor, are incompletely defined. In evaluating the role of SR-B1 in the biology of infection with SARS-CoV-2, influenza A virus, and vesicular stomatitis virus, we show that SR-B1 chemical inhibition or knockout adversely affects infection for these viruses. Inhibiting SR-B1 results in lack of acidification in the endolysosomal compartment and entrapment of SARS-CoV-2 in endosomal-lysosomal vesicles. These findings together indicate that SR-B1, and possibly HDL, is critical for successful SARS-CoV-2 trafficking through a pH-dependent vesicular entry pathway. Our work provides insights into how SR-B1 can impact viral infection in human lung cells.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112501"},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143924678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multilayer W-doped vanadium dioxide thermal sensors with extended operation region 扩展工作区域的多层掺w二氧化钒热传感器

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112528

Callum Wheeler , Yuxiao Zhu , Kai Sun , Bohao Ding , Ruomeng Huang , Otto L. Muskens , C.H. (Kees) de Groot

{"title":"Multilayer W-doped vanadium dioxide thermal sensors with extended operation region","authors":"Callum Wheeler , Yuxiao Zhu , Kai Sun , Bohao Ding , Ruomeng Huang , Otto L. Muskens , C.H. (Kees) de Groot","doi":"10.1016/j.isci.2025.112528","DOIUrl":"10.1016/j.isci.2025.112528","url":null,"abstract":"<div><div>Bolometers rely upon the temperature coefficient of resistance (TCR) of their underpinning sensing layer to detect infrared radiation. Vanadium dioxide (VO<sub>2</sub>) exhibits a very large, but abrupt TCR associated with its monoclinic to rutile phase transition. W-doping of VO<sub>2</sub> lowers and broadens its transition temperature, and by combining multiple discrete W:VO<sub>2</sub> layers, a sensing layer can be created with an extended temperature operation region. Herein, we report such a multilayer W:VO<sub>2</sub> thin film by atomic layer deposition (ALD). The film displays an average TCR of −9.5 (±3.5) %K<sup>−1</sup> from 30°C to 60°C. A sensing layer consisting of 10 individual W:VO<sub>2</sub> layers is simulated with a multi-objective genetic algorithm (MOGA) for maximum average TCR (μ) and minimum variation (σ) across an extended target temperature range producing an optimized layer structure at max (<span><math><mrow><mrow><mo>|</mo><mi>μ</mi><mo>|</mo></mrow><mo>−</mo><mi>σ</mi></mrow></math></span>) with average TCR response of −6.7 (±0.9) %K<sup>−1</sup> from 20°C to 70°C. This work highlights the potential for the broader application of uncooled bolometers.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112528"},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics 利用光遗传学技术研究板足形成过程中肌动蛋白细胞骨架和膜结构

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112529

Hironori Inaba , Tsuyoshi Imasaki , Kazuhiro Aoyama , Shogo Yoshihara , Hiroko Takazaki , Takayuki Kato , Hidemasa Goto , Kaoru Mitsuoka , Ryo Nitta , Takao Nakata

{"title":"Cryo-ET of actin cytoskeleton and membrane structure in lamellipodia formation using optogenetics","authors":"Hironori Inaba , Tsuyoshi Imasaki , Kazuhiro Aoyama , Shogo Yoshihara , Hiroko Takazaki , Takayuki Kato , Hidemasa Goto , Kaoru Mitsuoka , Ryo Nitta , Takao Nakata","doi":"10.1016/j.isci.2025.112529","DOIUrl":"10.1016/j.isci.2025.112529","url":null,"abstract":"<div><div>Lamellipodia are sheet-like protrusions essential for cell migration and endocytosis, but their ultrastructural dynamics remain poorly understood because conventional electron microscopy lacks temporal resolution. Here, we combined optogenetics with cryo-electron tomography (cryo-ET) to visualize the actin cytoskeleton and membrane structures during lamellipodia formation with temporal precision. Using photoactivatable-Rac1 (PA-Rac1) in COS-7 cells, we induced lamellipodia formation with a 2-min blue light irradiation, rapidly vitrified samples, and analyzed their ultrastructure with cryo-ET. We obtained 16 tomograms of lamellipodia at different degrees of extension from three cells. These revealed small protrusions with unbundled actin filaments, “mini filopodia” composed of short, bundled actin filaments at the leading edge, and actin bundles running nearly parallel to the leading edge within inner regions of lamellipodia, suggesting dynamic reorganizations of the actin cytoskeleton. This approach provides a powerful framework for elucidating the ultrastructural dynamics of cellular processes with precise temporal control.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112529"},"PeriodicalIF":4.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TLSNet: A semantic segmentation method for key point cloud regions of transmission lines TLSNet：一种输电线路关键点云区域的语义分割方法

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-24 DOI: 10.1016/j.isci.2025.112334

Shaotong Pei , Haichao Sun , Chenlong Hu , Weiqi Wang , Mianxiao Wu , Bo Lan

引用次数: 0

On the use of deep learning for computer-generated holography 关于在计算机生成全息术中使用深度学习

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-23 DOI: 10.1016/j.isci.2025.112507

Xuan Yu , Haomiao Zhang , Zhe Zhao , Xuhao Fan , Shaodong Hu , Zongjing Li , Wenbin Chen , Daqian Li , Shaoxi Shi , Wei Xiong , Hui Gao

引用次数: 0

Assessing the techno-economic benefits of LEMs for different grid topologies and prosumer shares 评估不同电网拓扑和产消份额的lem的技术经济效益

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-23 DOI: 10.1016/j.isci.2025.112493

Markus Doepfert , Soner Candas , Hermann Kraus , Peter Tzscheutschler , Thomas Hamacher

{"title":"Assessing the techno-economic benefits of LEMs for different grid topologies and prosumer shares","authors":"Markus Doepfert , Soner Candas , Hermann Kraus , Peter Tzscheutschler , Thomas Hamacher","doi":"10.1016/j.isci.2025.112493","DOIUrl":"10.1016/j.isci.2025.112493","url":null,"abstract":"<div><div>The shift toward decentralized and renewable energy sources has introduced significant challenges to traditional power systems, necessitating innovative market designs. Local energy markets present a viable solution for integrating distributed energy resources such as photovoltaic systems, electric vehicles, and heat pumps. This study investigates the techno-economic implications of local energy markets compared to conventional market designs, focusing on their impact on average energy prices and operational peak power. Through comprehensive simulations across various grid topologies with varying penetration levels of the distributed energy resources, totaling 400 simulation setups, we demonstrate that local energy markets can enhance economic efficiency and grid stability with 99% of the scenarios boasting lower average energy prices and 80% lower operational peak power levels. The findings suggest that local energy markets can play a role in the future energy system, provided that additional infrastructure, management costs, and bureaucratic complexity are kept to a minimum.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112493"},"PeriodicalIF":4.6,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0