iScience最新文献_第10页

Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype 在 COVID-19 治疗期间，口咽抗药性基因组保持稳定，而粪便抗药性基因组则向抗药性种类较少的方向转变

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111319

Elizaveta V. Starikova , Yulia S. Galeeva , Dmitry E. Fedorov , Elena V. Korneenko , Anna S. Speranskaya , Oksana V. Selezneva , Polina Y. Zoruk , Ksenia M. Klimina , Vladimir A. Veselovsky , Maxim D. Morozov , Daria I. Boldyreva , Evgenii I. Olekhnovich , Alexander I. Manolov , Alexander V. Pavlenko , Ivan E. Kozlov , Oleg O. Yanushevich , Natella I. Krikheli , Oleg V. Levchenko , Dmitry N. Andreev , Filipp S. Sokolov , Elena N. Ilina

{"title":"Oropharyngeal resistome remains stable during COVID-19 therapy, while fecal resistome shifts toward a less diverse resistotype","authors":"Elizaveta V. Starikova , Yulia S. Galeeva , Dmitry E. Fedorov , Elena V. Korneenko , Anna S. Speranskaya , Oksana V. Selezneva , Polina Y. Zoruk , Ksenia M. Klimina , Vladimir A. Veselovsky , Maxim D. Morozov , Daria I. Boldyreva , Evgenii I. Olekhnovich , Alexander I. Manolov , Alexander V. Pavlenko , Ivan E. Kozlov , Oleg O. Yanushevich , Natella I. Krikheli , Oleg V. Levchenko , Dmitry N. Andreev , Filipp S. Sokolov , Elena N. Ilina","doi":"10.1016/j.isci.2024.111319","DOIUrl":"10.1016/j.isci.2024.111319","url":null,"abstract":"<div><div>Antimicrobial resistance poses a serious threat to global public health. The COVID-19 pandemic underscored the need to monitor the dissemination of antimicrobial resistance genes and understand the mechanisms driving this process. In this study, we analyzed changes to the oropharyngeal and fecal resistomes of patients with COVID-19 undergoing therapy in a hospital setting. A targeted sequencing panel of 4,937 resistance genes was used to comprehensively characterize resistomes. Our results demonstrated that the oropharyngeal resistome is homogeneous, showing low variability over time. In contrast, fecal samples clustered into two distinct resistotypes that were only partially related to enterotypes. Approximately half of the patients changed their resistotype within a week of therapy, with the majority transitioning to a less diverse and <em>ermB</em>-dominated resistotype 2. Common macrolide resistance genes were identified in over 80% of both oropharyngeal and fecal samples, likely originating from streptococci. Our findings suggest that the fecal resistome is a dynamic system that can exist in certain “states” and is capable of transitioning from one state to another. To date, this is the first study to comprehensively describe the oropharyngeal resistome and its variability over time, and one of the first studies to demonstrate the temporal dynamics of the fecal resistotypes.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111319"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism TLX3在小脑发育过程中调控CGN祖细胞增殖，其功能障碍可导致自闭症

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111260

Surendran Parvathy , Budhaditya Basu , Suresh Surya , Rahul Jose , Vadakkath Meera , Paul Ann Riya , Nair Pradeep Jyothi , Rajendran Sanalkumar , Viviane Praz , Nicolò Riggi , Biju Surendran Nair , Kamalesh K. Gulia , Mukesh Kumar , Balachandran Krishnamma Binukumar , Jackson James

{"title":"TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism","authors":"Surendran Parvathy , Budhaditya Basu , Suresh Surya , Rahul Jose , Vadakkath Meera , Paul Ann Riya , Nair Pradeep Jyothi , Rajendran Sanalkumar , Viviane Praz , Nicolò Riggi , Biju Surendran Nair , Kamalesh K. Gulia , Mukesh Kumar , Balachandran Krishnamma Binukumar , Jackson James","doi":"10.1016/j.isci.2024.111260","DOIUrl":"10.1016/j.isci.2024.111260","url":null,"abstract":"<div><div><em>Tlx3</em>, a master regulator of the fate specification of excitatory neurons, is primarily known to function in post-mitotic cells. Although we have previously identified TLX3 expression in the proliferating granule neuron progenitors (GNPs) of cerebellum, its primary role is unknown. Here, we demonstrate that the dysfunction of <em>Tlx3</em> from the GNPs significantly reduced its proliferation through regulating anti-proliferative genes. Consequently, the altered generation of GNPs resulted in cerebellar hypoplasia, patterning defects, granule neuron-Purkinje ratio imbalance, and aberrant synaptic connections in the cerebellum. This altered cerebellar homeostasis manifested into a typical autism-like behavior in mice with motor, and social function disabilities. We also show the presence of <em>TLX3</em> variants with uncharacterized mutations in human cases of autism spectrum disorder (ASD). Altogether, our study establishes <em>Tlx3</em> as a critical gene involved in developing GNPs and that its deletion from the early developmental stage culminates in autism.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111260"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Defining health equity: A modern US perspective 定义健康公平：现代美国视角

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111326

Kristen R. Prentice , Marie Beitelshees , Andrew Hill , Charles H. Jones

引用次数: 0

Sustainable and smart rail transit based on advanced self-powered sensing technology 基于先进自供电传感技术的可持续智能轨道交通

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111306

Hongjie Tang , Lingji Kong , Zheng Fang , Zutao Zhang , Jianhong Zhou , Hongyu Chen , Jiantong Sun , Xiaolong Zou

{"title":"Sustainable and smart rail transit based on advanced self-powered sensing technology","authors":"Hongjie Tang , Lingji Kong , Zheng Fang , Zutao Zhang , Jianhong Zhou , Hongyu Chen , Jiantong Sun , Xiaolong Zou","doi":"10.1016/j.isci.2024.111306","DOIUrl":"10.1016/j.isci.2024.111306","url":null,"abstract":"<div><div>As rail transit continues to develop, expanding railway networks increase the demand for sustainable energy supply and intelligent infrastructure management. In recent years, advanced rail self-powered technology has rapidly progressed toward artificial intelligence and the internet of things (AIoT). This review primarily discusses the self-powered and self-sensing systems in rail transit, analyzing their current characteristics and innovative potentials in different scenarios. Based on this analysis, we further explore an IoT framework supported by sustainable self-powered sensing systems including device nodes, network communication, and platform deployment. Additionally, technologies about cloud computing and edge computing deployed in railway IoT enable more effective utilization. The deployed intelligent algorithms such as machine learning (ML) and deep learning (DL) can provide comprehensive monitoring, management, and maintenance in railway environments. Furthermore, this study explores research in other cross-disciplinary fields to investigate the potential of emerging technologies and analyze the trends for future development in rail transit.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111306"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Radiative cooling technology with artificial intelligence 人工智能辐射冷却技术

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111325

Yeongju Jung , Seung Hwan Ko

引用次数: 0

Linking new information to a short-lasting memory trace induces consolidation in the hippocampus 将新信息与短暂记忆痕迹联系起来可诱导海马体巩固记忆

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111320

Andressa Gabriela Soliani , Jessica Santos Baptista , Beatriz Gangale Muratori , Lucia Armelin Correa , Suzete Maria Cerutti

引用次数: 0

From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling 从采样到模拟：系统病理生理学建模中的单细胞多组学

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111322

Alexandra Manchel , Michelle Gee , Rajanikanth Vadigepalli

引用次数: 0

Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets 脂肪移植诱导的溶血磷脂酰胆碱通过影响 ACC 神经元周围网的功能障碍来调节痛觉减退

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111274

Juan Li , Zhen Li , Yanbo Liu , Yijing Li , Yanqiong Wu , Anne Manyande , Zhixiao Li , Hongbing Xiang

{"title":"Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets","authors":"Juan Li , Zhen Li , Yanbo Liu , Yijing Li , Yanqiong Wu , Anne Manyande , Zhixiao Li , Hongbing Xiang","doi":"10.1016/j.isci.2024.111274","DOIUrl":"10.1016/j.isci.2024.111274","url":null,"abstract":"<div><div>The pathogenesis of hyperalgesia is complex and can lead to poor clinical treatment. Our study revealed that epididymal white adipose tissue (eWAT) from spared nerve injury (SNI) mice is involved in the occurrence of hyperalgesia after adipose tissue transplantation. We also showed that lysophosphatidylcholine (LPC) is enriched in the eWAT of SNI mice using non-targeted metabolomic analysis and verified that the levels of LPC in plasma and the anterior cingulate cortex (ACC) region increased following eWAT transplantation. Based on the immunohistochemistry results, we observed that LPC in the ACC region activated microglia via the TRPV1/CamkⅡ pathway. Meanwhile, the disruption of perineuronal nets (PNNs) around PV<sup>+</sup> neurons in ACC promoted hyperalgesia, and the loss of PNNs and PV<sup>+</sup> interneurons might be due to microglial phagocytosis. These findings elucidate the mechanism underlying hyperalgesia from the perspective of lipid metabolite LPC and PNNs and provide potential strategies for the treatment of hyperalgesia.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111274"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence 胶质母细胞瘤对纺锤体抑制剂的抗药性取决于 STAT3 和治疗诱导的衰老

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111311

Natanael Zarco , Athanassios Dovas , Virginea de Araujo Farias , Naveen K.H. Nagaiah , Ashley Haddock , Peter A. Sims , Dolores Hambardzumyan , Christian T. Meyer , Peter Canoll , Steven S. Rosenfeld , Rajappa S. Kenchappa

{"title":"Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence","authors":"Natanael Zarco , Athanassios Dovas , Virginea de Araujo Farias , Naveen K.H. Nagaiah , Ashley Haddock , Peter A. Sims , Dolores Hambardzumyan , Christian T. Meyer , Peter Canoll , Steven S. Rosenfeld , Rajappa S. Kenchappa","doi":"10.1016/j.isci.2024.111311","DOIUrl":"10.1016/j.isci.2024.111311","url":null,"abstract":"<div><div>While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3. Furthermore, these senescent cells expand the repertoire of cells resistant to these drugs by secreting an array of factors, including TGF<u>β</u>, which induce proliferating cells to exit mitosis and become quiescent—a state that also resists spindle inhibitors. Targeting STAT3 restores sensitivity to each of these drugs by depleting the senescent subpopulation and inducing quiescent cells to enter the mitotic cycle. These results support a therapeutic strategy of targeting STAT3-dependent therapy-induced senescence to enhance the efficacy of spindle inhibitors for the treatment of glioblastoma.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111311"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Happy new ears: Rapid adaptation to novel spectral cues in vertical sound localization 快乐的新耳朵在垂直声音定位中快速适应新的频谱线索

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-04 DOI: 10.1016/j.isci.2024.111308

Cesare Parise , Monica Gori , Sara Finocchietti , Marc Ernst , Davide Esposito , Alessia Tonelli

引用次数: 0