iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111955
Marwan Sendi , Matthias Mersch , Niall Mac Dowell
{"title":"Electrolytic hydrogen production; how green must green be?","authors":"Marwan Sendi , Matthias Mersch , Niall Mac Dowell","doi":"10.1016/j.isci.2025.111955","DOIUrl":"10.1016/j.isci.2025.111955","url":null,"abstract":"<div><div>Electrolytic hydrogen from renewable sources is central to many nations’ net-zero emission strategies, serving as a low-carbon alternative for traditional uses and enabling decarbonization across multiple sectors. Current stringent policies in the EU and US are set to soon require hourly time matching of renewable electricity generation used by electrolyzers, aimed at ensuring that hydrogen production does not cause significant direct or indirect emissions. While such requirements enhance the “green credentials” of hydrogen, they also increase its production costs. A modest relaxation of these requirements offers a practicable route for scaling up low-carbon hydrogen production, optimizing both costs and emission reductions. Moreover, in jurisdictions with credible and near-to-medium-term decarbonization targets, immediate production of electrolytic hydrogen utilizing grid electricity would have a lifetime carbon intensity comparable to or even below blue hydrogen and very significantly less than that of diesel, emphasizing the need to prioritize rapid grid decarbonization of the broader grid.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111955"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-03DOI: 10.1016/j.isci.2025.111947
Nayana S. Tellakula , Eva-Maria S. Collins , William B. Kristan Jr.
{"title":"Regeneration in planarians modifies behavioral switching","authors":"Nayana S. Tellakula , Eva-Maria S. Collins , William B. Kristan Jr.","doi":"10.1016/j.isci.2025.111947","DOIUrl":"10.1016/j.isci.2025.111947","url":null,"abstract":"<div><div>The planarian <em>Dugesia japonica</em> responds differently to localized stimuli: anterior regions turn, middle regions elongate, and posterior regions contract. If cut into several pieces, each piece immediately produces the same three responses. Over several days, each piece regenerates all transected body parts. This study tested how the pieces coordinate behavioral responses during regeneration. We first determined the locations of the turning/elongation and elongation/contraction behavioral switches. Immediately, all transections moved both switching sites away from the cut sites so that the worm pieces produced the same three responses as intact worms. During regeneration, the sites of behavioral switching moved progressively closer to the transection (now regeneration) sites. These results show that the immediate effects of transection (likely physiological) are coordinated with the addition of regenerating tissue (anatomical) to maintain as normal an animal as possible. Other animals that regenerate body parts, such as amphibians and reptiles, may use similar coordination mechanisms.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111947"},"PeriodicalIF":4.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-03DOI: 10.1016/j.isci.2025.111948
Yinan Yuan , Sidney M. Levy , Yong Qiang Yeo , Ramin Shayan , Tara Karnezis , Steven A. Stacker , Marc G. Achen
{"title":"Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice","authors":"Yinan Yuan , Sidney M. Levy , Yong Qiang Yeo , Ramin Shayan , Tara Karnezis , Steven A. Stacker , Marc G. Achen","doi":"10.1016/j.isci.2025.111948","DOIUrl":"10.1016/j.isci.2025.111948","url":null,"abstract":"<div><div>Secondary lymphedema is a debilitating chronic tissue swelling in a limb caused by inadequate interstitial fluid drainage due to dysfunctional lymphatic vessels. Pathological enlargement of small lymphatics contributes to lymphatic dysfunction in secondary lymphedema, but molecular mechanisms driving this remodeling are unclear. Here, using a surgical mouse model of secondary lymphedema and whole-genome microarray, we identified the transcript for insulin-like growth factor binding protein 5 (IGFBP5), a negative regulator of insulin-like growth factor (IGF) signaling, as the most profoundly down-regulated in lymphedematous tissue. Notably, IGF signaling via IGF1 receptor (IGF1R) was previously shown to promote lymphatic remodeling. We therefore targeted IGF1R in the mouse model using the small molecule IGF1R inhibitor linsitinib. Linsitinib restricted enlargement of small lymphatics and tissue swelling during lymphedema development, likely by inhibiting IGF1R-driven vascular endothelial growth factor-C (VEGF-C) synthesis by macrophages. Importantly, linsitinib profoundly reduced tissue swelling in mice with chronic lymphedema suggesting IGF signaling as a therapeutic target for this disease.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111948"},"PeriodicalIF":4.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-03DOI: 10.1016/j.isci.2025.111944
Yang Li , Xueye Wang , Lehui Ren , Ruobin Dai , Zhiwei Qiu , Huimin Zhou , Zhiwei Wang
{"title":"Membrane modification strategies for virus removal from water","authors":"Yang Li , Xueye Wang , Lehui Ren , Ruobin Dai , Zhiwei Qiu , Huimin Zhou , Zhiwei Wang","doi":"10.1016/j.isci.2025.111944","DOIUrl":"10.1016/j.isci.2025.111944","url":null,"abstract":"<div><div>Membrane technology, through innovative approaches such as nanocomposite membranes, membrane bioreactors, and electrocatalytic membrane reactors, offers a synergistic platform for pathogen removal. This review examines recent advancements in membrane modifications aimed at optimizing virus removal efficiency. It outlines various mechanisms employed in these innovations, including size exclusion, electronic interactions, hydrophobic and hydrophilic interactions, and pathogen inactivation. By systematically discussing the modifications and the intrinsic properties of viruses that affect their interactions with these membranes, the review highlights the potential of advanced functional materials tailored to specific membrane processes. Emphasis is placed on the necessity of adjusting membrane pore sizes and enhancing other physical and chemical properties (e.g., electrochemical oxidation performance) to improve efficacy. Overall, this review comprehensively assesses various membrane technologies, comparing their effectiveness and providing theoretical insights and practical guidance on utilizing membrane modifications to safeguard water against viral contaminants.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111944"},"PeriodicalIF":4.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-03DOI: 10.1016/j.isci.2025.111950
Nicole D. Wernet , Eillen Tecle , Mario Bardan Sarmiento , Cheng-Ju Kuo , Crystal B. Chhan , Ian Baick , Lakshmi E. Batachari , Latisha Franklin , Alice Herneisen , Gira Bhabha , Damian C. Ekiert , Wendy Hanna-Rose , Emily R. Troemel
{"title":"Adenosine deaminase and deoxyadenosine regulate intracellular immune response in C. elegans","authors":"Nicole D. Wernet , Eillen Tecle , Mario Bardan Sarmiento , Cheng-Ju Kuo , Crystal B. Chhan , Ian Baick , Lakshmi E. Batachari , Latisha Franklin , Alice Herneisen , Gira Bhabha , Damian C. Ekiert , Wendy Hanna-Rose , Emily R. Troemel","doi":"10.1016/j.isci.2025.111950","DOIUrl":"10.1016/j.isci.2025.111950","url":null,"abstract":"<div><div>Adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are enzymes in the purine salvage pathway, which recycles purines to meet cellular demands. Mutations of these enzymes in humans cause inflammatory and immunodeficiency syndromes, but the mechanisms are not well understood. Prior work in the nematode <em>Caenorhabditis elegans</em> demonstrated that loss of PNP ortholog PNP-1 induced an immune response called the intracellular pathogen response (IPR). Here, we show that loss of the enzyme upstream of PNP-1 called ADAH-1 (ADA homolog) also induces the IPR and promotes resistance against intracellular pathogens. Unlike PNP-1, ADAH-1 is essential for organismal development. Importantly, we find that supplementation of deoxyadenosine, a substrate for ADA, induces the IPR and promotes resistance to intracellular pathogens in <em>C. elegans</em>, a finding we extend to human cells. Thus, mutations in ADA and PNP induce innate immunity through increased deoxyadenosine, a phenomenon that is conserved from <em>C. elegans</em> to humans.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111950"},"PeriodicalIF":4.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-03DOI: 10.1016/j.isci.2025.111949
Katja G. Schmidt , Paulina Geißler , Ev-Marie Schuster , Christine Schülein , Ellen G. Harrer , Verena Schönau , Markus Luber , Bernd Spriewald , Philipp Steininger , Silke Bergmann , Armin Ensser , Kilian Schober , Krystelle Nganou-Makamdop , Thomas Harrer
{"title":"Coronavirus replicase epitopes induce cross-reactive CD8 T cell responses in SARS-CoV-2-naive people with HIV-1","authors":"Katja G. Schmidt , Paulina Geißler , Ev-Marie Schuster , Christine Schülein , Ellen G. Harrer , Verena Schönau , Markus Luber , Bernd Spriewald , Philipp Steininger , Silke Bergmann , Armin Ensser , Kilian Schober , Krystelle Nganou-Makamdop , Thomas Harrer","doi":"10.1016/j.isci.2025.111949","DOIUrl":"10.1016/j.isci.2025.111949","url":null,"abstract":"<div><div>Cross-reactive T cell immunity between common cold coronaviruses and SARS-CoV-2 may influence COVID-19 susceptibility. To identify cross-reactive CD8 T cell epitopes, we analyzed responses to 21 homologous SARS-CoV-2 replicase peptides in 177 people living with HIV (PLWH) on antiretroviral therapy, of which 133 did not have prior SARS-CoV-2 infection. Replicase peptides induced IFN-γ responses in 63% of the SARS-CoV-2-naïve individuals and in 73% of individuals with prior SARS-CoV-2-infection. We could define several cross-reactive epitopes, including the HLA-B∗35:03 restricted CoV-YL8, and characterized a CoV-YL8-specific T cell receptor cloned from a SARS-CoV-2 seronegative individual. Analysis of the association between HLA-I alleles and SARS-CoV-2 infections over a 16-months period revealed that in a cohort of 452 PLWH, HLA-B∗35:03 and C∗07 were underrepresented in the 55 persons with a history of SARS-CoV-2 infection while HLA-B∗35:01 and HLA-C∗04 were associated with a higher infection rate. Taken together, our study suggests an HLA-I-mediated effect of common cold coronaviruses on SARS-CoV-2 immunity.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111949"},"PeriodicalIF":4.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-01DOI: 10.1016/j.isci.2025.111943
Caterina De Rosa , Floriana Morgillo , Luisa Amato , Francesca Iommelli , Viviana De Rosa , Virginia Tirino , Federica Papaccio , Concetta Tuccillo , Gaetano Di Guida , Domenico Michele D’Angiolella , Alessandra Di Liello , Silvia Zappavigna , Michele Caraglia , Antonio Gambardella , Valerio Nardone , Kavya Ramkumar , Qi Wang , Jing Wang , Ferdinando De Vita , Davide Ciardiello , Carminia Maria Della Corte
{"title":"DNA-PK inhibition sustains the antitumor innate immune response in small cell lung cancer","authors":"Caterina De Rosa , Floriana Morgillo , Luisa Amato , Francesca Iommelli , Viviana De Rosa , Virginia Tirino , Federica Papaccio , Concetta Tuccillo , Gaetano Di Guida , Domenico Michele D’Angiolella , Alessandra Di Liello , Silvia Zappavigna , Michele Caraglia , Antonio Gambardella , Valerio Nardone , Kavya Ramkumar , Qi Wang , Jing Wang , Ferdinando De Vita , Davide Ciardiello , Carminia Maria Della Corte","doi":"10.1016/j.isci.2025.111943","DOIUrl":"10.1016/j.isci.2025.111943","url":null,"abstract":"<div><div>Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer with limited treatment options. Patients often respond well to initial chemo-immunotherapy but relapse quickly, necessitating new strategies to enhance immune responsiveness. Recent research explores combining DNA-damaging therapies with immunotherapy to activate the STING pathway and improve the antitumor immune response. The addition of DNA Damage Repair (DDR) inhibitors, such as DNA-PKcs inhibitors, after chemotherapy has shown promise in activating innate immune sensors and enhancing CD8<sup>+</sup> T cell and NK cell pathways in SCLC models. This approach could potentially reshape the tumor microenvironment and sustain an antitumor immune response, offering a maintenance strategy for SCLC treatment.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111943"},"PeriodicalIF":4.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-01eCollection Date: 2025-02-21DOI: 10.1016/j.isci.2025.111921
Jing Liu, Yimin Feng, Mian Zheng, Shangkai Chen, Pengran Wang, Mengdan Zhao, Zhaoxian Huang, Ming Li
{"title":"Ultra-thin rapeseed oil-assisted femtosecond laser etching on quartz glass microgrooves.","authors":"Jing Liu, Yimin Feng, Mian Zheng, Shangkai Chen, Pengran Wang, Mengdan Zhao, Zhaoxian Huang, Ming Li","doi":"10.1016/j.isci.2025.111921","DOIUrl":"https://doi.org/10.1016/j.isci.2025.111921","url":null,"abstract":"<p><p>Liquid-assisted methods can effectively suppress thermal effects, such as recrystallization, micro-cracks, and edge collapses of hard and brittle materials in femtosecond laser processing in air. However, the small and numerous bubbles generated by water solvents seriously affect laser processing efficiency. We have investigated ultra-thin rapeseed oil-assisted (approximately <math><mrow><mn>58</mn> <mspace></mspace> <mi>μ</mi> <mi>m</mi></mrow> </math> thickness) femtosecond laser processing of quartz glass microgrooves. Experimental results show that rapeseed oil-assisted laser ablation reduces the adverse effects of bubbles through the bubble coalescence effect but also helps to discharge the bottom debris via the formed micro-jet. According to the ionization model with the Drude equation, the laser intensity to reach the damage threshold of quartz in rapeseed oil is lower than that in air. Based on heat conduction theory, rapeseed oil can effectively reduce the quartz glass's temperature gradient. The ultra-thin rapeseed oil-assisted femtosecond laser etching method has strong potential and important practical significance in etching glass material.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 2","pages":"111921"},"PeriodicalIF":4.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143539800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-01DOI: 10.1016/j.isci.2025.111930
Peter J. Szachowicz , Christine Wohlford-Lenane , Cobey J. Donelson , Shreya Ghimire , Andrew Thurman , Biyun Xue , Timothy J. Boly , Abhishek Verma , Leila MašinoviĆ , Jennifer R. Bermick , Tayyab Rehman , Stanley Perlman , David K. Meyerholz , Alejandro A. Pezzulo , Yuzhou Zhang , Richard J.H. Smith , Paul B. McCray Jr.
{"title":"Complement is primarily activated in the lung in a mouse model of severe COVID-19","authors":"Peter J. Szachowicz , Christine Wohlford-Lenane , Cobey J. Donelson , Shreya Ghimire , Andrew Thurman , Biyun Xue , Timothy J. Boly , Abhishek Verma , Leila MašinoviĆ , Jennifer R. Bermick , Tayyab Rehman , Stanley Perlman , David K. Meyerholz , Alejandro A. Pezzulo , Yuzhou Zhang , Richard J.H. Smith , Paul B. McCray Jr.","doi":"10.1016/j.isci.2025.111930","DOIUrl":"10.1016/j.isci.2025.111930","url":null,"abstract":"<div><div><em>In vitro</em> studies and observational human disease data suggest the complement system contributes to SARS-CoV-2 pathogenesis, although how complement dysregulation develops in severe COVID-19 is unknown. Here, using a mouse-adapted SARS-CoV-2 virus (SARS2-N501Y<sub>MA30</sub>) and a mouse model of COVID-19, we identify significant serologic and pulmonary complement activation post-infection. We observed C3 activation in airway and alveolar epithelia, and pulmonary vascular endothelia. Our evidence suggests the alternative pathway is the primary route of complement activation, however, components of both the alternative and classical pathways are produced locally by respiratory epithelial cells following infection, and increased in primary cultures of human airway epithelia following cytokine and SARS-CoV-2 exposure. This tissue-specific complement response appears to precede lung injury and inflammation. Our results suggest that complement activation is a defining feature of severe COVID-19 in mice, agreeing with previous publications, and provide the basis for further investigation into the role of complement in COVID-19.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111930"},"PeriodicalIF":4.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143402591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-01DOI: 10.1016/j.isci.2025.111942
Hugo M. Botelho , Miquéias Lopes-Pacheco , Madalena C. Pinto , Violeta Railean , Ines Pankonien , Mariana F. Caleiro , Luka A. Clarke , Vasco Cachatra , Beate Neumann , Christian Tischer , Cristina Moiteiro , Jiraporn Ousingsawat , Karl Kunzelmann , Rainer Pepperkok , Margarida D. Amaral
{"title":"Global functional genomics reveals GRK5 as a cystic fibrosis therapeutic target synergistic with current modulators","authors":"Hugo M. Botelho , Miquéias Lopes-Pacheco , Madalena C. Pinto , Violeta Railean , Ines Pankonien , Mariana F. Caleiro , Luka A. Clarke , Vasco Cachatra , Beate Neumann , Christian Tischer , Cristina Moiteiro , Jiraporn Ousingsawat , Karl Kunzelmann , Rainer Pepperkok , Margarida D. Amaral","doi":"10.1016/j.isci.2025.111942","DOIUrl":"10.1016/j.isci.2025.111942","url":null,"abstract":"<div><div>Cystic fibrosis (CF) is a life-shortening disease affecting >160,000 individuals worldwide predominantly with respiratory symptoms. About 80% of individuals with CF have the p.Phe508del variant that causes the CF transmembrane conductance regulator (CFTR) protein to misfold and be targeted for premature degradation by the endoplasmic reticulum (ER) quality control (ERQC), thus preventing its plasma membrane (PM) traffic. Despite the recent approval of a “highly effective” drug rescuing p.Phe508del-CFTR, maximal lung function improvement is ∼14%. To identify global modulators of p.Phe508del traffic, we performed a high-content small interfering RNA (siRNA) microscopy-based screen of >9,000 genes and monitored p.Phe508del-CFTR PM rescue in human airway cells. This primary screen identified 227 p.Phe508del-CFTR traffic regulators, of which 35 could be validated by additional siRNAs. Subsequent mechanistic studies established GRK5 as a robust regulator whose inhibition rescues p.Phe508del-CFTR PM traffic and function in primary and immortalized cells, thus emerging as a novel potential drug target for CF.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111942"},"PeriodicalIF":4.6,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
