iScience最新文献_第9页

Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-13 DOI: 10.1016/j.isci.2025.112221

Marta La Vecchia , Michela Giulia Clavenna , Marika Sculco , Gloria Sala , Denise Marradi , Elettra Barberis , Soni Joseph , Marta Mellai , Nico Pagano , Renzo Boldorini , Barbara Azzimonti , Elisa Bona , Edoardo Pasolli , Flavia Prodam , Carlotta Sacerdote , Daniela Ferrante , Emilia Ghelardi , Marcello Manfredi , Anna Aspesi , Irma Dianzani

{"title":"Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors","authors":"Marta La Vecchia , Michela Giulia Clavenna , Marika Sculco , Gloria Sala , Denise Marradi , Elettra Barberis , Soni Joseph , Marta Mellai , Nico Pagano , Renzo Boldorini , Barbara Azzimonti , Elisa Bona , Edoardo Pasolli , Flavia Prodam , Carlotta Sacerdote , Daniela Ferrante , Emilia Ghelardi , Marcello Manfredi , Anna Aspesi , Irma Dianzani","doi":"10.1016/j.isci.2025.112221","DOIUrl":"10.1016/j.isci.2025.112221","url":null,"abstract":"<div><div>Here, we aim to improve our understanding of various colorectal cancer (CRC) risk factors (obesity, unhealthy diet, and gut microbiota/metabolome alteration), analyzing 120 patients with colon polyps, divided in normal-weight (NW) or overweight/obese (OB). Dietary habits data (validated EPIC questionnaires) revealed a higher consumption of processed meat among OB vs. NW patients. Both mucosa-associated microbiota (MAM) on polyps and lumen-associated microbiota (LAM) analyses uncovered distinct bacterial signatures in the two groups. Importantly, we found an enrichment of the pathogenic species <em>Finegoldia magna</em> in MAM of OB patients, regardless of their polyp stage. We observed distinct mucosal-associated metabolome signatures, with OB patients showing increased pyroglutamic acid and reduced niacin levels, and performed microbiota-metabolome integrated analysis. These findings support a model where different risk factors may contribute to tumorigenesis in OB vs. NW patients, highlighting the potential impact of processed meat consumption and <em>F. magna</em> on CRC development among OB patients.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112221"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-13 DOI: 10.1016/j.isci.2025.112220

Maria Bolla , Giulia Colombo , Matteo Falappa , Marta Pace , Roman Baravalle , Nataniel Martinez , Fernando Montani , Valter Tucci , Laura Cancedda

{"title":"NKCC1 inhibition improves sleep quality and EEG information content in a Down syndrome mouse model","authors":"Maria Bolla , Giulia Colombo , Matteo Falappa , Marta Pace , Roman Baravalle , Nataniel Martinez , Fernando Montani , Valter Tucci , Laura Cancedda","doi":"10.1016/j.isci.2025.112220","DOIUrl":"10.1016/j.isci.2025.112220","url":null,"abstract":"<div><div>In several brain disorders, the hyperpolarizing/inhibitory effects of GABA signaling through Cl-permeable GABA<sub>A</sub> receptors are compromised, leading to an imbalance between neuronal excitation and inhibition. For example, the Ts65Dn mouse model of Down syndrome (DS) exhibits increased expression of the Cl<sup>−</sup> importer NKCC1, leading to depolarizing gamma aminobutyric acid (GABA) signaling in the mature hippocampus and cortex. Inhibiting NKCC1 with the Food and Drug Administration (FDA)-approved diuretic bumetanide rescues inhibitory GABAergic transmission, synaptic plasticity, and cognitive functions in adult Ts65Dn mice.</div><div>Given that DS individuals and Ts65Dn mice show sleep disturbances, and considering the key role of GABAergic transmission in sleep, we investigated whether NKCC1 upregulation contributes to sleep abnormalities in adult Ts65Dn mice. Chronic oral administration of bumetanide ameliorated the spectral profile of sleep, sleep architecture, and electroencephalogram (EEG) entropy/complexity, accompanied by a lower hyperactivity in trisomic mice. These results offer a potential avenue for addressing common sleep disturbances in DS.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112220"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143705509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-13 DOI: 10.1016/j.isci.2025.112215

Ping-Zhou Wang , Ming-Hai Ge , Pan Su , Piao-Ping Wu , Lei Wang , Wei Zhu , Rong Li , Hui Liu , Jing-Jing Wu , Yu Xu , Jia-Lu Zhao , Si-Jia Li , Yan Wang , Li-Ming Chen , Tai-Hong Wu , Zheng-Xing Wu

{"title":"Sensory plasticity caused by up-down regulation encodes the information of short-term learning and memory","authors":"Ping-Zhou Wang , Ming-Hai Ge , Pan Su , Piao-Ping Wu , Lei Wang , Wei Zhu , Rong Li , Hui Liu , Jing-Jing Wu , Yu Xu , Jia-Lu Zhao , Si-Jia Li , Yan Wang , Li-Ming Chen , Tai-Hong Wu , Zheng-Xing Wu","doi":"10.1016/j.isci.2025.112215","DOIUrl":"10.1016/j.isci.2025.112215","url":null,"abstract":"<div><div>Learning and memory are essential for animals’ well-being and survival. The underlying mechanisms are a major task of neuroscience studies. In this study, we identified a circuit consisting of ASER, RIC, RIS, and AIY, is required for short-term salt chemotaxis learning (SCL) in <em>C. elegans</em>. ASER NaCl-sensation possesses are remodeled by salt/food-deprivation pared conditioning. RIC integrates the sensory information of NaCl and food availability. It excites ASER and inhibits AIY by tyramine/TYRA-2 and octopamine/OCTR-1 signaling pathways, respectively. By the salt conditioning, RIC NaCl calcium response to NaCl is depressed, thus, the RIC excitation of ASER and inhibition of AIY are suppressed. ASER excites RIS by FLP-14/FRPR-10 signaling. RIS inhibits ASER via PDF-2/PDFR-1 signaling in negative feedback. ASER sensory plasticity caused by RIC plasticity and RIS negative feedback are required for both learning and memory recall. Thus, the sensation plasticity encodes the information of the short-term SCL that facilitates animal adaptation to dynamic environments.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112215"},"PeriodicalIF":4.6,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets involved in motor neuron development

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-12 DOI: 10.1016/j.isci.2025.112210

Catarina Catela , Stavroula Assimacopoulos , Yihan Chen , Konstantinos Tsioras , Weidong Feng , Paschalis Kratsios

{"title":"The Iroquois (Iro/Irx) homeobox genes are conserved Hox targets involved in motor neuron development","authors":"Catarina Catela , Stavroula Assimacopoulos , Yihan Chen , Konstantinos Tsioras , Weidong Feng , Paschalis Kratsios","doi":"10.1016/j.isci.2025.112210","DOIUrl":"10.1016/j.isci.2025.112210","url":null,"abstract":"<div><div>The <em>Iroquois (Iro/Irx)</em> homeobox genes encode transcription factors with fundamental roles in animal development. Despite their link to various congenital conditions in humans, our understanding of <em>Iro/Irx</em> gene expression, function, and regulation remains incomplete. Here, we conducted a systematic expression analysis of all six mouse <em>Irx</em> genes in the embryonic spinal cord. We found that <em>Irx1</em>, <em>Irx2</em>, <em>Irx3</em>, <em>Irx5</em>, and <em>Irx6</em> are expressed in specific groups of motor neurons (MNs). Further, we employed CRISPR-Cas9 gene editing to uncover essential but distinct roles for <em>Irx2</em> and <em>Irx6</em> in MN development. We also found that HOX proteins, which are conserved regulators of MN development across species, control <em>Irx</em> gene expression both in mouse and <em>Caenorhabditis elegans</em> MNs. Altogether, our study provides insights into <em>Iro/Irx</em> expression and function in the developing spinal cord and uncovers an ancient gene regulatory relationship between HOX and <em>Iro/Irx</em> genes.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112210"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior hypothalamic nucleus drives distinct defensive responses through cell-type-specific activity

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-12 DOI: 10.1016/j.isci.2025.112097

Cindy Yookyung Hong , Jessica Sofia Din , Hannah Chang , Jee Yoon Bang , Jun Chul Kim

{"title":"Anterior hypothalamic nucleus drives distinct defensive responses through cell-type-specific activity","authors":"Cindy Yookyung Hong , Jessica Sofia Din , Hannah Chang , Jee Yoon Bang , Jun Chul Kim","doi":"10.1016/j.isci.2025.112097","DOIUrl":"10.1016/j.isci.2025.112097","url":null,"abstract":"<div><div>Innate defensive behaviors are essential for survival, allowing animals to appropriately respond to predatory threats. The anterior hypothalamic nucleus (AHN), a key region in the medial hypothalamic defense system, contains both GABAergic and glutamatergic neurons, reflecting a sophisticated balance between inhibitory and excitatory signaling. However, the specific behavioral functions of these neuronal populations have not been systemically examined. Here, we utilized fiber photometry and optogenetic stimulation to investigate the roles of AHN GABAergic, glutamatergic, and CaMKIIa+ neuronal activities in mediating innate defensive behaviors. Our results indicate that AHN GABAergic neurons mediate anxiety-associated investigatory behaviors, while AHN glutamatergic neurons drive escape and freezing responses. The AHN CaMKIIa+ neurons, which exhibit significant heterogeneity, suggest a more nuanced role, potentially balancing escape and freezing responses. Our study provides a foundation for future investigations into the neural circuits underlying innate defensive behaviors and its dysregulation in neuropsychiatric conditions including PTSD and panic disorder.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112097"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular basis of circadian rhythm divergence between diurnal and nocturnal lepidoperans

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-12 DOI: 10.1016/j.isci.2025.112206

Guiyun Li , Qian Cui , Shirui Zheng , Kaixiang Zhang , Yaohui Wang , Shuai Zhan , Gangqi Fang

{"title":"Molecular basis of circadian rhythm divergence between diurnal and nocturnal lepidoperans","authors":"Guiyun Li , Qian Cui , Shirui Zheng , Kaixiang Zhang , Yaohui Wang , Shuai Zhan , Gangqi Fang","doi":"10.1016/j.isci.2025.112206","DOIUrl":"10.1016/j.isci.2025.112206","url":null,"abstract":"<div><div>Understanding the molecular basis of nocturnal and diurnal behaviors is crucial to uncovering adaptive specialization. Here, we employed the black cutworm (<em>Agrotis ipsilon</em>, BCW) to examine the rhythmic gene repertoire in nocturnal species. Daily eclosion patterns confirmed BCW’s nocturnal behavior. We generated daily transcriptomes for BCW and compared them with those of the diurnal monarch butterfly (<em>Danaus plexippus</em>). Both species share a core set of genes with rhythmic expression, indicating a fundamental timekeeping mechanism in Lepidoptera. Notably, metabolism-related genes exhibited significant phase shifts between BCW and the monarch butterfly, suggesting that metabolic differences underpin their contrasting behaviors. Additionally, while phototransduction genes in monarch butterflies show marginal rhythmicity, in BCW these genes are governed by light sensitivity rather than circadian regulation. This study provides molecular insights into the diversification of behavioral traits between diurnal and nocturnal insects.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112206"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143706141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FMNL2/SRC-mediated androgen receptor translocation into the nucleus promotes enzalutamide resistance of prostate cancer

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-12 DOI: 10.1016/j.isci.2025.112205

Jianpeng Yu , Yukui Gao , Mingpeng Zhang , Yue Gao , Chun Wang , Yuanjie Niu , Zhiqun Shang

{"title":"FMNL2/SRC-mediated androgen receptor translocation into the nucleus promotes enzalutamide resistance of prostate cancer","authors":"Jianpeng Yu , Yukui Gao , Mingpeng Zhang , Yue Gao , Chun Wang , Yuanjie Niu , Zhiqun Shang","doi":"10.1016/j.isci.2025.112205","DOIUrl":"10.1016/j.isci.2025.112205","url":null,"abstract":"<div><div>Enzalutamide, a second-generation androgen receptor (AR) antagonist, has represented the association with improved overall survival in men with prostate cancer (PCa). However, PCa patients receiving enzalutamide will eventually develop resistance through various mechanisms without effective regimens. Here, we observed a higher level of formin-like 2 (FMNL2) in enzalutamide-resistant PCa cells. Functionally, FMNL2 knockdown partially re-sensitized enzalutamide-resistant PCa cells. Mechanistically, FMNL2 directly interacted with SRC kinase through FMNL2-FH1 and SRC-SH3 domain, which induced AR translocation from the cytoplasm to the nucleus, resulting in increased expression of the AR-targeted genes and leading to resistance to enzalutamide. Consistently, SRC inhibitor dasatinib rescued enzalutamide sensitivity and inhibited the proliferation of enzalutamide-resistant cancer cells. Taken together, our findings demonstrate a substantial role for FMNL2/SRC interaction in the regulation of AR translocation, suggesting that targeting FMNL2-mediated SRC activation might be a potential therapeutic strategy for enzalutamide-resistant PCa and dasatinib could be an option.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112205"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143695938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional and structural organization of medial entorhinal cortex layer VI

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-12 DOI: 10.1016/j.isci.2025.112207

Märt Rannap , Shinya Ohara , Janis Winterstein , Fabian C. Roth , Andreas Draguhn , Alexei V. Egorov

{"title":"Functional and structural organization of medial entorhinal cortex layer VI","authors":"Märt Rannap , Shinya Ohara , Janis Winterstein , Fabian C. Roth , Andreas Draguhn , Alexei V. Egorov","doi":"10.1016/j.isci.2025.112207","DOIUrl":"10.1016/j.isci.2025.112207","url":null,"abstract":"<div><div>Deep layers (V/VI) of the entorhinal cortex transfer hippocampal neuronal activity to downstream neocortical networks. In addition, neurons in layer VI (LVI) of the medial entorhinal cortex (MEC) project back to all hippocampal subregions and contribute to spatial coding and memory. Their role in the processing of hippocampal output signals and their interaction with LV neurons is, however, unknown. We show that spontaneously occurring hippocampal sharp wave-ripple complexes reliably propagate from area CA1 to MEC LVI. Using anterograde tracing and <em>in vitro</em> optogenetics, we confirm direct hippocampal projections to LVI and show that these follow a parallel dorsoventral topography. Further investigation of the MEC deep layer network revealed very sparse excitatory connections between LVI and LVb or LVI and LVa neurons in both directions. Together, our results establish organizational principles for the hippocampal-MEC LVI output circuit and suggest largely parallel signal processing through different cellular subpopulations in MEC deep layers.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112207"},"PeriodicalIF":4.6,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spinal implant wear particles: Generation, characterization, biological impacts, and future considerations

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-11 DOI: 10.1016/j.isci.2025.112193

Renata Ganko , Aswini Madhavan , Waeel Hamouda , Sathish Muthu , Amit Jain , S. Tim Yoon , Hiba El-Rozz , Divya Cyril , Moreica Pabbruwe , Joanne L. Tipper , Javad Tavakoli

{"title":"Spinal implant wear particles: Generation, characterization, biological impacts, and future considerations","authors":"Renata Ganko , Aswini Madhavan , Waeel Hamouda , Sathish Muthu , Amit Jain , S. Tim Yoon , Hiba El-Rozz , Divya Cyril , Moreica Pabbruwe , Joanne L. Tipper , Javad Tavakoli","doi":"10.1016/j.isci.2025.112193","DOIUrl":"10.1016/j.isci.2025.112193","url":null,"abstract":"<div><div>The generation of wear debris from orthopedic implants is a known cause of implant failure, particularly in joint replacements. While much research has focused on wear particles from knee and hip implants, spinal implants, such as total disc replacements (TDRs), have received less attention despite their increasing clinical use. Spinal implants face unique biomechanical challenges, including a wider range of motion and higher loads, leading to complex tissue interactions. Studies reveal that TDR wear particles, though similar in size to those from knee implants, cause a stronger immune response, with more macrophages and giant cells found in the surrounding tissue. This may explain the high revision rates seen in spinal surgeries, with some interventions failing in over 30% of cases within 10 years. The younger population undergoing spinal surgery, combined with the productivity losses associated with implant failure, underscores the need for greater understanding. This review discusses recent research on the generation, characterization, and biological impacts of spinal implant wear debris. It draws on retrieval analysis, wear simulation, <em>in vivo</em> models, and a survey conducted with the AO Spine Knowledge Forum Degenerative to assess current clinical practices and highlight gaps in knowledge. Additionally, this critical review explores future strategies to reduce the biological impact of wear particles and improve the safety and longevity of spinal implants through better therapeutics and design innovations. By combining literature and clinical insights, this paper aims to guide future research in addressing the complexities of spinal implant wear and its biological consequences.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112193"},"PeriodicalIF":4.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143684465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-03-11 DOI: 10.1016/j.isci.2025.112196

Chengbin Yang , Shiqi Tang , Qiqi Liu , Miaozhuang Fan , Wenguang Zhang , Yingyu Liu , Xin Chen , Gaixia Xu , Xiaoyan Chen , Zhourui Xu

{"title":"Wireless charging LED mediated type I photodynamic therapy of breast cancer using NIR AIE photosensitizer","authors":"Chengbin Yang , Shiqi Tang , Qiqi Liu , Miaozhuang Fan , Wenguang Zhang , Yingyu Liu , Xin Chen , Gaixia Xu , Xiaoyan Chen , Zhourui Xu","doi":"10.1016/j.isci.2025.112196","DOIUrl":"10.1016/j.isci.2025.112196","url":null,"abstract":"<div><div>Due to limited light penetration and dependence on oxygen, photodynamic therapy (PDT) is typically restricted to treating shallow tissues. Developing strategies to overcome these limitations and effectively using PDT for tumor treatment is a significant yet unresolved challenge. In this study, we present a smart approach combining a wireless-charged LED (wLED) with a type I aggregation-induced emission photosensitizer, MeOTTMN, to address both light penetration and tumor hypoxia issues simultaneously. MeOTTMN, characterized by twisted molecular architecture and strong intramolecular electron donor-acceptor interaction, produces high levels of hydroxyl and superoxide radicals and emits near-infrared light in its aggregated state, thus facilitating fluorescence imaging-guided PDT once formulated into nanoparticles. The inhibition of breast cancer xenografts provides compelling evidence of the treatment efficacy of type I PDT irradiated through an implantable wLED. This strategy provides a conceptual and practical paradigm to overcome key clinical limitations of PDT, expanding possibilities for clinical translation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 4","pages":"Article 112196"},"PeriodicalIF":4.6,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143714910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0