iScience最新文献_第8页

In vivo reprogramming of NG2 glia improves bladder function after spinal cord injury 体内NG2神经胶质细胞重编程改善脊髓损伤后膀胱功能

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114850

Wenjiao Tai , Junkui Shang , Peiqi Zhao , Wei Li , Tianjin Shen , Xiaoling Zhong , Yuhua Zou , Bo Chen , Chun-Li Zhang

引用次数: 0

From observation to protection a bibliometric analysis of aerosol-glacier interactions 从观察到保护：气溶胶-冰川相互作用的文献计量学分析

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-30 DOI: 10.1016/j.isci.2026.114672

Hongfei Meng , Feiteng Wang , Shuangshuang Liu , Xiang Jin , Mengwei Xu , Jianxin Mu

{"title":"From observation to protection a bibliometric analysis of aerosol-glacier interactions","authors":"Hongfei Meng , Feiteng Wang , Shuangshuang Liu , Xiang Jin , Mengwei Xu , Jianxin Mu","doi":"10.1016/j.isci.2026.114672","DOIUrl":"10.1016/j.isci.2026.114672","url":null,"abstract":"<div><div>Remote sensing has become a central approach for investigating interactions between atmospheric aerosols and glacier change under climate warming. Here, we apply bibliometric and science-mapping methods to systematically analyze global research on remote sensing of aerosol-glacier interactions from 1995 to 2024. Based on 523 publications, we identify rapid growth since 2013 and reveal a tripolar collaboration structure linking North America, Europe, and Asia. Thematic analyses show a clear evolution from early observational and retrieval studies toward process-oriented research emphasizing black carbon deposition, snow-ice energy balance, and regional glacier mass balance. Journal dual-map overlays and cluster dependency analysis further demonstrate that the field is supported by Earth sciences, physics-chemistry, and computational systems, with aerosol type and scientific assessment serving as key foundational clusters. Overall, this study outlines the knowledge structure and evolution of aerosol-glacier research, supporting interdisciplinary monitoring and protection strategies in a changing climate.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114672"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A framework to evaluate the applicability of ET products in the southeastern coastal basins of China 中国东南沿海盆地蒸散发产品适用性评价框架

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-03 DOI: 10.1016/j.isci.2026.114880

Jiao Chen , Xingwei Chen , Huaxia Yao , Weifang Ruan , Feng Lin , Haijun Deng , Xiaocheng Li

{"title":"A framework to evaluate the applicability of ET products in the southeastern coastal basins of China","authors":"Jiao Chen , Xingwei Chen , Huaxia Yao , Weifang Ruan , Feng Lin , Haijun Deng , Xiaocheng Li","doi":"10.1016/j.isci.2026.114880","DOIUrl":"10.1016/j.isci.2026.114880","url":null,"abstract":"<div><div>Accurate estimation of evapotranspiration (ET) is crucial for watershed eco-environmental research and applicability of ET products in southeastern coastal basins of China needs to be evaluated. We proposed an improved evaluation framework for basin applicability of ET products. Based on assessing the overall rationality and correcting ET products using water balance method, the temporal dynamics of corrected products ET (ET<sub>C</sub>) were assessed by dual-variable calibrated SWAT model. Application of this framework in three basins in southeastern coastal China showed that three corrected products ET were consistent in magnitude, but differed markedly in inter-annual and intra-annual variability. Compared with SWAT-ET, ET<sub>C_SSEBOP</sub> exhibited a better performance in temporal dynamics, followed by ET<sub>C_FLDAS</sub>, and ET<sub>C_MOD16A2</sub> was the worst. The simulation performance of products on forestland ET was a potential influencing factor to these differences. The proposed assessment framework for ET products provided a more holistic assessment of their applicability, yielding more reliable results.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114880"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPARγ activation rescues oxidative stress-induced embryonic arrest by suppressing Wnt/β-catenin signaling via GSK3β upregulation PPARγ激活通过GSK3β上调抑制Wnt/β-catenin信号传导来挽救氧化应激诱导的胚胎停止

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-30 DOI: 10.1016/j.isci.2026.114870

Lihong Liu , Siyao Ha , Hui Chen , MingQing Li , Zhiling Li

{"title":"PPARγ activation rescues oxidative stress-induced embryonic arrest by suppressing Wnt/β-catenin signaling via GSK3β upregulation","authors":"Lihong Liu , Siyao Ha , Hui Chen , MingQing Li , Zhiling Li","doi":"10.1016/j.isci.2026.114870","DOIUrl":"10.1016/j.isci.2026.114870","url":null,"abstract":"<div><div>Excessive reactive oxygen species (ROS) during assisted reproductive technology (ART) impairs embryonic development, yet the intrinsic molecular mechanisms remain inadequately understood. Through transcriptomic profiling (Drug-seq) of oxidatively stressed mouse embryos, we identified peroxisome proliferator-activated receptor gamma (PPARγ) as a critical regulator whose essential upregulation during zygotic genome activation (ZGA) is suppressed. Functional studies demonstrated that the pharmacological activation of PPARγ via the agonist GW1929 robustly rescued developmental arrest by scavenging ROS, restoring mitochondrial function, and maintaining metabolic homeostasis. Mechanistically, we demonstrate that PPARγ activation transcriptionally upregulates GSK3β, which in turn suppresses oxidative stress-induced aberrant Wnt/β-catenin signaling. Our findings establish PPARγ as a central guardian of embryonic redox and metabolic homeostasis, and propose PPARγ agonism as a potential strategy to improve ART outcomes by counteracting oxidative injury.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114870"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The past, present, and future of peaking thermal power plants in the United States 美国峰值火力发电厂的过去、现在和未来

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-02 DOI: 10.1016/j.isci.2026.114886

Max Vanatta , Brian Sergi , Wesley Cole , Paul Denholm , Trieu Mai

引用次数: 0

Functional diversity of fish in the Yuan-Red River: Role of species turnover and trait shifts. 元红河鱼类功能多样性：物种更替和性状变化的作用

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 eCollection Date: 2026-04-17 DOI: 10.1016/j.isci.2026.115418

Xiao-Xia Huang, Ai-Ling Yang, Bin Kang, Ke-Jian He, Xiao-Han Mei, Wen-Xian Hu, Hung-Du Lin

引用次数: 0

PCMTD1-127aa suppresses osteosarcoma progression by competitively binding to USP10 to promote c-MYC degradation PCMTD1-127aa通过竞争性结合USP10促进c-MYC降解来抑制骨肉瘤的进展

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-01-29 DOI: 10.1016/j.isci.2026.114765

Anan Li , Shijiang Wang , Fan Li , Xu Xiong , Ning Liu , Xinsheng Xie , Geliang Yao , Zhili Liu , Meiying Yan , Feng Yang

{"title":"PCMTD1-127aa suppresses osteosarcoma progression by competitively binding to USP10 to promote c-MYC degradation","authors":"Anan Li , Shijiang Wang , Fan Li , Xu Xiong , Ning Liu , Xinsheng Xie , Geliang Yao , Zhili Liu , Meiying Yan , Feng Yang","doi":"10.1016/j.isci.2026.114765","DOIUrl":"10.1016/j.isci.2026.114765","url":null,"abstract":"<div><div>Osteosarcoma (OS) is a highly malignant tumor prone to distant metastasis and is associated with a poor prognosis. To date, therapeutic outcomes for this disease remain unsatisfactory. In this study, we found that circPCMTD1 encodes a 127-amino acid protein, termed PCMTD1-127aa in OS. The expression of PCMTD1-127aa was significantly lower in OS tissues than in normal paratumoral tissues. Clinical data analysis revealed that low expression of PCMTD1-127aa was associated with poor OS prognosis. Functionally, overexpression of PCMTD1-127aa not only inhibited the proliferation and invasion of osteosarcoma cells but also suppressed glycolysis in these cells. Mechanistically, PCMTD1-127aa competitively bound to the F1 (1–100) domain of USP10, thereby counteracting the USP10-mediated deubiquitination of c-MYC and subsequently promoting c-MYC degradation. We further identified that amino acid 148 of c-MYC plays a critical role in ubiquitination-mediated degradation. Our findings reveal the PCMTD1-127aa/USP10/c-MYC axis may be a promising therapeutic target for OS.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114765"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Art as a source of historical biodiversity data 艺术作为历史生物多样性数据的来源

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-04 DOI: 10.1016/j.isci.2026.114873

Jiajia Liu , Charles Davis

引用次数: 0

Identification of DARPP-32 as a novel sleep regulator in physiological conditions and experimental Parkinsonism DARPP-32在生理条件和实验性帕金森病中作为一种新的睡眠调节因子的鉴定

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-02 DOI: 10.1016/j.isci.2026.114882

Clarissa Anna Pisanò , Maria Laura Santino , Alice Russotto , Gilberto Fisone

{"title":"Identification of DARPP-32 as a novel sleep regulator in physiological conditions and experimental Parkinsonism","authors":"Clarissa Anna Pisanò , Maria Laura Santino , Alice Russotto , Gilberto Fisone","doi":"10.1016/j.isci.2026.114882","DOIUrl":"10.1016/j.isci.2026.114882","url":null,"abstract":"<div><div>Sleep disorders are common in Parkinson’s disease (PD) and respond poorly to current pharmacological treatments, partly due to limited understanding of their underlying mechanisms. Using polysomnographic recordings, we investigated the role of dopamine- and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) in sleep-wake regulation and PD-related sleep dysfunction. In naive mice, the selective ablation of DARPP-32 in striatal projection neurons (SPN) co-expressing dopamine D2 and adenosine A2A receptors reduced NREM sleep during the active phase of the circadian cycle, whereas its deletion in dopamine D1 receptor-expressing SPN increased NREM sleep stability during the inactive phase. In a mouse model of PD, excessive daytime sleepiness (EDS), a common non-motor symptom in PD, was abolished by DARPP-32 deletion in D2R/A2AR-expressing SPN but not in D1R-expressing SPN, which also failed to improve sleep fragmentation. Together, these findings identify DARPP-32 as a key regulator of sleep-wake function and a cell-specific target for alleviating PD-related EDS.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114882"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer 线粒体复合体V的可逆解离平衡了癌症中合成代谢和能量产生的需要

IF 4.1 2区综合性期刊

iScience Pub Date : 2026-03-20 Epub Date: 2026-02-02 DOI: 10.1016/j.isci.2026.114889

Huabo Wang , Jie Lu , Colin Henchy , Steven J. Mullett , Adam C. Richert , Eric S. Goetzman , Ahmet Toksoz , Leonardo Hale , Brandon B. Wang , Nelli Mnatsakanyan , Edward V. Prochownik

{"title":"Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer","authors":"Huabo Wang , Jie Lu , Colin Henchy , Steven J. Mullett , Adam C. Richert , Eric S. Goetzman , Ahmet Toksoz , Leonardo Hale , Brandon B. Wang , Nelli Mnatsakanyan , Edward V. Prochownik","doi":"10.1016/j.isci.2026.114889","DOIUrl":"10.1016/j.isci.2026.114889","url":null,"abstract":"<div><div>Cancer cell metabolic re-programming provides the additional energy and anabolic precursors necessary to sustain unregulated proliferation. This is partially mediated by the Warburg effect, which generates ATP while oxidizing glucose to a subset of these anabolites. Concurrently, mitochondrial mass and ATP generation via oxidative phosphorylation decline in most tumors. This raises the question of how increased glycolysis-derived anabolites can be balanced with those supplied by the TCA cycle. Using primary murine liver cancers and their derivative cell lines, we show that this can be explained by the dissociation of mitochondrial Complex V (CV or ATP synthase) into its component and functionally independent F<sub>o</sub> and F<sub>1</sub> domains. This occurs as a result of marked declines in MT-ATP6, a CV subunit that stabilizes F<sub>o</sub>-F<sub>1</sub> assembly. Serving as a proton pore, free F<sub>o</sub> maintains a normal mitochondrial membrane potential without generating ATP, thus allowing the TCA cycle, electron transport chain, and anaplerotic reactions to function at high levels. Concurrently, free F<sub>1</sub> functions in reverse as an ATPase to limit excess ATP accumulation. The uncoupling of TCA-cycle-derived anabolic substrate production from membrane hyperpolarization and ATP overproduction by a smaller population of highly efficient mitochondria allows TCA-cycle-generated anabolic precursors to match those generated via glycolysis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"29 3","pages":"Article 114889"},"PeriodicalIF":4.1,"publicationDate":"2026-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146187218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0