iSciencePub Date : 2025-02-05DOI: 10.1016/j.isci.2025.111959
Alexander George , Naghmeh Akhavan , Bradford E. Peercy , Michelle Starz-Gaiano
{"title":"Chemotaxis of Drosophila border cells is modulated by tissue geometry through dispersion of chemoattractants","authors":"Alexander George , Naghmeh Akhavan , Bradford E. Peercy , Michelle Starz-Gaiano","doi":"10.1016/j.isci.2025.111959","DOIUrl":"10.1016/j.isci.2025.111959","url":null,"abstract":"<div><div>Migratory cells respond to graded concentrations of diffusible chemoattractants <em>in vitro</em>, but how complex tissue geometries <em>in vivo</em> impact chemotaxis is poorly understood. To address this, we studied the Drosophila border cells. Live-imaged border cells varied in their chemotactic migration speeds, which correlated positionally with distinct architectures. We then developed a reduced mathematical model to determine how chemoattractant distribution is affected by tissue architecture. Larger extracellular volumes locally dampened the chemoattractant gradient and, when coupled with an agent-based motion of the cluster, reduced cell speeds. This suggests that chemoattractant levels vary by tissue architectures, informing cell migration behaviors locally, which we tested <em>in vivo.</em> Genetically elevating chemoattractant levels slowed migration in specific architectural regions, while mutants with spacious tissue structure rescued defects from high chemoattractant levels, promoting punctual migration. Our results highlight the interplay between tissue geometry and the local distribution of signaling molecules to orchestrate cell migration.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111959"},"PeriodicalIF":4.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-05DOI: 10.1016/j.isci.2025.111954
Ni Yin , Xian Xie , Dan Li , Shikun Yang , Yan Liu , Yongzhong Tang , Hao Zhang , Wei Zhang
{"title":"tRF-Val-TAC-004 protects against renal ischemia-reperfusion injury via attenuating Apaf1-mediated apoptosis","authors":"Ni Yin , Xian Xie , Dan Li , Shikun Yang , Yan Liu , Yongzhong Tang , Hao Zhang , Wei Zhang","doi":"10.1016/j.isci.2025.111954","DOIUrl":"10.1016/j.isci.2025.111954","url":null,"abstract":"<div><div>tRNA-derived fragments (tRFs) play critical roles in cellular process, and we have previously reported that tRFs are involved in ischemia reperfusion injury induced acute kidney injury (IRI-AKI). However, the precise involvement of tRFs in IRI-AKI remains obscure. This study aims to elucidate the impact of tRF-Val-TAC-004 (tRF-Val) on IRI-AKI and uncover the underlying mechanisms. Our observations reveal a significant downregulation of tRF-Val in IRI-AKI mice and its overexpression mitigated renal dysfunction, morphological damage, and apoptosis in IRI-AKI mice, while its inhibition exacerbated these effects. Similar outcomes were replicated in CoCl<sub>2</sub>-treated BUMPT cells upon transfection with tRF-Val mimic or inhibitor. Mechanistically, dual-luciferase reporter assay and AGO-RIP qPCR analyses demonstrated that tRF-Val suppresses Apaf1 expression by targeting the 3′-UTR of <em>Apaf1</em> mRNA. Furthermore, the protective efficacy of tRF-Val was notably weakened by <em>Apaf1</em>-overexpressing plasmids. In summary, these novel findings unveil the protective role of tRF-Val against IRI-AKI through inhibition of Apaf1-mediated apoptosis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111954"},"PeriodicalIF":4.6,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111876
Nataša Obermajer , Adam Zwolak , Kelly van de Ven , Shana Versmissen , Krista Menard , Katharine Rogers , Ted Petley , Dan Weinstock , Jason Aligo , Jaymala Patel , Ken Tian , Lorraine Angelillo , Fang Yi , Stephen Jarantow , Keith Schutsky , Yoshitomo Hamuro , Diana Alvarez Arias , Kristel Buyens , Tsun-Wen Sheena Yao , Vince Torti , Sylvie Laquerre
{"title":"JNJ-78306358, a first-in-class bispecific T cell engaging antibody targeting CD3 and HLA-G","authors":"Nataša Obermajer , Adam Zwolak , Kelly van de Ven , Shana Versmissen , Krista Menard , Katharine Rogers , Ted Petley , Dan Weinstock , Jason Aligo , Jaymala Patel , Ken Tian , Lorraine Angelillo , Fang Yi , Stephen Jarantow , Keith Schutsky , Yoshitomo Hamuro , Diana Alvarez Arias , Kristel Buyens , Tsun-Wen Sheena Yao , Vince Torti , Sylvie Laquerre","doi":"10.1016/j.isci.2025.111876","DOIUrl":"10.1016/j.isci.2025.111876","url":null,"abstract":"<div><div>T cell-redirecting bispecific antibodies (bsAbs) to treat advanced stage solid tumors are gaining interest after recent clinical successes. The immune checkpoint human leukocyte antigen G (HLA-G) is expressed in several tumor types while in normal tissues expression is limited. Here, we describe JNJ-78306358, a T cell-redirecting bispecific antibody (bsAb) to treat advanced stage solid tumors. JNJ-78306358 binds with high affinity to the α3 subunit of HLA-G on cancer cells and with purposely engineered weaker affinity to CD3ε on T cells. JNJ-78306358 induced potent T cell-mediated cytotoxicity of HLA-G-expressing solid tumors <em>in vitro</em> and <em>in vivo</em>. JNJ-78306358 also blocked the interaction of HLA-G with its receptors <em>in vitro</em>, indicating that immune checkpoint blocking may contribute to its anti-tumor activity. These results suggest that T cell-redirection against HLA-G could be a potent and effective treatment for a wide range of solid tumor indications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111876"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111952
Feng Wang , Yan-Hou Liu , Ting Zhang , Xintong Hou , Yanbao Xin , Guang-Yao Xie , Wen-Jie Zhao , Xue Wang , Tianmeng Sun , Zheng Hu , Yong-Guang Yang
{"title":"Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function","authors":"Feng Wang , Yan-Hou Liu , Ting Zhang , Xintong Hou , Yanbao Xin , Guang-Yao Xie , Wen-Jie Zhao , Xue Wang , Tianmeng Sun , Zheng Hu , Yong-Guang Yang","doi":"10.1016/j.isci.2025.111952","DOIUrl":"10.1016/j.isci.2025.111952","url":null,"abstract":"<div><div>Thrombospondin-1 (TSP-1)/CD47 signaling induces cell death and inhibits angiogenesis. Here, we investigated the possibility of improving donor engraftment by blocking the TSP-1/CD47 pathway in mouse models of total body irradiation (TBI)-conditioned syngeneic hematopoietic stem cell transplantation (HSCT). Our findings revealed that HSCT engraftment was improved in mice deficient in CD47 (<em>Cd47</em><sup><em>−/−</em></sup>) or TSP-1 (<em>Thbs1</em><sup><em>−/−</em></sup>) compared to wild-type (WT) mice. The lack of TSP-1 or CD47 enhanced the production of CXCL12 by megakaryocytes and platelets, promoting the seeding of donor hematopoietic stem cells (HSCs) in sinusoidal endothelial cell (SEC)/megakaryocyte niches. Both <em>Cd47</em><sup><em>−/−</em></sup> and <em>Thbs1</em><sup><em>−/−</em></sup> mice showed reduced platelet adhesion to sinusoidal vascular cells, attenuated endothelial injury, and enhanced BM vascular regeneration, preserving SEC niches. Antibody neutralization of TSP-1 significantly increased CXCL12 production, donor HSC engraftment, and vascular niche regeneration in WT mice. In summary, the TSP-1/CD47 pathway is a promising therapeutic target to enhance HSCT efficacy and reduce endothelial injury syndrome.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111952"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111945
Asif Gulraiz , Azizeh J. Al Bastaki , Khulood Magamal , Mina Subhi , Abdallah Hammad , Abdulrahman Allanjawi , Sajjad Haider Zaidi , Haris M. Khalid , Abdulla Ismail , Ghulam Amjad Hussain , Zafar Said
{"title":"Energy advancements and integration strategies in hydrogen and battery storage for renewable energy systems","authors":"Asif Gulraiz , Azizeh J. Al Bastaki , Khulood Magamal , Mina Subhi , Abdallah Hammad , Abdulrahman Allanjawi , Sajjad Haider Zaidi , Haris M. Khalid , Abdulla Ismail , Ghulam Amjad Hussain , Zafar Said","doi":"10.1016/j.isci.2025.111945","DOIUrl":"10.1016/j.isci.2025.111945","url":null,"abstract":"<div><div>The long term and large scale energy storage operations require quick response time and round-trip efficiency, which are not feasible with conventional battery systems. To address this issue while endorsing high energy density, long term storage, and grid adaptability, the hydrogen energy storage (HES) is preferred. This proposed work makes a comprehensive review on HES while synthesizing recent research on energy storage technologies and integration into renewable energy (RE) applications. The proposed research also identifies critical challenges related to system optimization, energy management strategies, and economic viability while featuring emerging technologies like artificial intelligence (AI) and machine learning (ML) for energy management. The proposed survey also discusses key advancements in battery technologies (lithium-ion, Ni-Cd, Ni/MH, and flow batteries) that are examined alongside innovations in HES methods. The proposed survey utilizes an extensive list of publications to date in the open literature to canvass and portray various developments in this area.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111945"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111929
Xueji Feng , Xiaoyu Bao , Haiyun Huang , Zijian Wang , Wen Hu , Chenxi Xue , Zhiqing Song , Yuexin Cai , Qiyun Huang , Yuanqing Li
{"title":"Frontal gamma-alpha ratio reveals neural oscillatory mechanism of attention shifting in tinnitus","authors":"Xueji Feng , Xiaoyu Bao , Haiyun Huang , Zijian Wang , Wen Hu , Chenxi Xue , Zhiqing Song , Yuexin Cai , Qiyun Huang , Yuanqing Li","doi":"10.1016/j.isci.2025.111929","DOIUrl":"10.1016/j.isci.2025.111929","url":null,"abstract":"<div><div>In clinical practice, the symptoms of tinnitus patients can be temporarily alleviated by diverting their attention away from disturbing sounds. However, the precise mechanisms through which this alleviation occurs are still not well understood. Here, we aimed to directly evaluate the role of attention in tinnitus alleviation by conducting distraction tasks with multilevel loads and resting-state tests among 52 adults with tinnitus and 52 healthy controls. We demonstrated that the abnormal neural oscillations in tinnitus subjects, reflected in an altered gamma/alpha ratio index in the frontal lobe, could be regulated by attention shifting in a linear manner for which the regulatory effect increased with the load of distraction. Quantitative measures of the regulation significantly correlated with symptom severity. Altogether, our work provides proof-of-concept for the role of attention in tinnitus perception and lays a solid foundation to support evidence-based applications of attention shifting in clinical interventions for tinnitus.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111929"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04eCollection Date: 2025-02-21DOI: 10.1016/j.isci.2025.111917
Michelle C D Bridi, Nancy Luo, Grace Kim, Benjamin J Menarchek, Rachel A Lee, Bryan Rodriguez, Daniel Severin, Cristian Moreno, Altagracia Contreras, Christian Wesselborg, Caroline O'Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood
{"title":"Erratum: Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism.","authors":"Michelle C D Bridi, Nancy Luo, Grace Kim, Benjamin J Menarchek, Rachel A Lee, Bryan Rodriguez, Daniel Severin, Cristian Moreno, Altagracia Contreras, Christian Wesselborg, Caroline O'Ferrall, Ruchit Patel, Sarah Bertrand, Sujatha Kannan, Alfredo Kirkwood","doi":"10.1016/j.isci.2025.111917","DOIUrl":"https://doi.org/10.1016/j.isci.2025.111917","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1016/j.isci.2024.111494.].</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 2","pages":"111917"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111946
Stephanie Makdissi , Rihab Loudhaief , Smitha George , Tabatha Weller , Minna Salim , Ahsan Malick , Yizhu Mu , Brendon D. Parsons , Francesca Di Cara
{"title":"Alterations in ether phospholipids metabolism activate the conserved UPR-Xbp1- PDIA3/ERp60 signaling to maintain intestinal homeostasis","authors":"Stephanie Makdissi , Rihab Loudhaief , Smitha George , Tabatha Weller , Minna Salim , Ahsan Malick , Yizhu Mu , Brendon D. Parsons , Francesca Di Cara","doi":"10.1016/j.isci.2025.111946","DOIUrl":"10.1016/j.isci.2025.111946","url":null,"abstract":"<div><div>Intestinal epithelium regeneration and homeostasis must be tightly regulated. Alteration of epithelial homeostasis is a major contributing factor to diseases such as colorectal cancer and inflammatory bowel diseases. Many pathways involved in epithelial regeneration have been identified, but more regulators remain undiscovered. Metabolism has emerged as an overlooked regulator of intestinal epithelium homeostasis. Using the model organism <em>Drosophila melanogaster</em>, we found that ether lipids metabolism is required to maintain intestinal epithelial homeostasis. Its dysregulation in intestinal progenitors causes the activation of the unfolded protein response of the endoplasmic reticulum (UPR) that triggers Xbp1 and upregulates the conserved disulfide isomerase PDIA3/ERp60. Activation of the Xbp1-ERp60 signaling causes Jak/Stat-mediated increase in progenitor cells, compromising epithelial barrier function and survival in males but not females. This study identified ether lipids-PDIA3/ERp60 as a key regulator of intestinal progenitor homeostasis in health that, if altered, causes pathological conditions in the intestinal epithelium.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111946"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143421657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
iSciencePub Date : 2025-02-04DOI: 10.1016/j.isci.2025.111938
Rachel A. Bender Ignacio , Kara W. Chew , Carlee Moser , Judith S. Currier , Joseph J. Eron , Arzhang Cyrus Javan , Mark J. Giganti , Justin Ritz , Michael Gibbs , Hervé Tchouakam Kouekam , Mark T. Esser , Eric S. Daar , Manish Choudhary , Rinki Deo , Courtney V. Fletcher , Jonathan Z. Li , Michael D. Hughes , Davey Smith , David Alain Wohl , for the ACTIV-2/A5401 Study Team
{"title":"Tixagevimab/cilgavimab or placebo for COVID-19 in ACTIV-2: Safety, pharmacokinetics and neutralizing and anti-drug antibodies","authors":"Rachel A. Bender Ignacio , Kara W. Chew , Carlee Moser , Judith S. Currier , Joseph J. Eron , Arzhang Cyrus Javan , Mark J. Giganti , Justin Ritz , Michael Gibbs , Hervé Tchouakam Kouekam , Mark T. Esser , Eric S. Daar , Manish Choudhary , Rinki Deo , Courtney V. Fletcher , Jonathan Z. Li , Michael D. Hughes , Davey Smith , David Alain Wohl , for the ACTIV-2/A5401 Study Team","doi":"10.1016/j.isci.2025.111938","DOIUrl":"10.1016/j.isci.2025.111938","url":null,"abstract":"<div><div>Monoclonal antibodies have potential as rapidly developable agents for treatment and prevention of emerging viruses. The ACTIV-2 trial randomized persons with mild-moderate COVID-19 to the monoclonal antibody combination tixagevimab/cilgavimab via intramuscular injection (600 mg IM) or infusion (300 mg IV) versus placebo. We present final safety and laboratory outcomes; primary outcomes were previously reported. The analyzed IM group included 214 participants, and the IV group, 106 participants. Adverse events were not different between treatment and placebo. The half-life of both components was >90 days for IM or 75 days for IV. New anti-drug antibodies were about 3 times more likely in active vs. placebo recipients. SARS-CoV-2 neutralizing antibodies increased 157-fold at 7 days and 127-fold at 1 month (IM-treated) but were less robust in IV participants. These data can inform future development of monoclonal antibodies against SARS-CoV-2 and other viruses, even if this intervention is of low utility for contemporary SARS-CoV-2 variants.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111938"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy","authors":"Jean Pierre Bikorimana , Roudy Farah , Jamilah Abusarah , Gabrielle Arona Mandl , Mohamed Ali Erregragui , Marina Pereira Gonçalves , Sebastien Talbot , Perla Matar , Malak Lahrichi , Nehme El-Hachem , Moutih Rafei","doi":"10.1016/j.isci.2025.111957","DOIUrl":"10.1016/j.isci.2025.111957","url":null,"abstract":"<div><div>Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses. Retrovirally gene-engineered MSCs were evaluated for their <em>in-vitro</em> antigen presentation capacity, nature of generated peptide repertoire and therapeutic potency in syngeneic immunocompetent mice with pre-established solid T cell lymphoma. Despite lack of noticeable changes in gene expression, MSC-UBvR-OVA vaccination triggered potent T cell activation which can be attributable to the enriched cell surface presentation of OVA-derived peptides added to elevated mitochondrial reactive oxidative species (ROS) production, the latter being associated with efficient antigen processing. Where MSC-UBvR-OVA vaccination successfully controlled tumor growth in cancer-bearing mice, the effect is further enhanced using tranylcypromine-stimulated MSCs and anti-PD-1 combination. Such anti-tumoral response relies on efferocytosis by endogenous phagocytes. Altogether, UBvR facilitated forced antigen degradation represents a plausible modality for future development of tumor antigen-expressing MSC-based vaccine.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111957"},"PeriodicalIF":4.6,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
