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Repurposing HFC-125 to tetrafluoroethylene: A step toward a more sustainable fluoropolymer feedstock strategy 将HFC-125重新用于四氟乙烯：朝着更可持续的含氟聚合物原料战略迈出的一步

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-03 DOI: 10.1016/j.isci.2025.112580

Hiroto Iwasaki , Naoyuki Hoshiya , Yosuke Kishikawa , Jorge Escorihuela , Norio Shibata

{"title":"Repurposing HFC-125 to tetrafluoroethylene: A step toward a more sustainable fluoropolymer feedstock strategy","authors":"Hiroto Iwasaki , Naoyuki Hoshiya , Yosuke Kishikawa , Jorge Escorihuela , Norio Shibata","doi":"10.1016/j.isci.2025.112580","DOIUrl":"10.1016/j.isci.2025.112580","url":null,"abstract":"<div><div>The urgency to reduce hydrofluorocarbon (HFC) emissions, particularly HFC-125 (pentafluoroethane, CF<sub>3</sub>CF<sub>2</sub>H), has driven efforts to develop sustainable alternatives. Herein, we present a method for converting HFC-125 into tetrafluoroethylene (TFE), an industrially valuable monomer for fluoropolymer production. Our approach uses potassium hexamethyldisilazide (KHMDS), optimizing reaction conditions at −50°C to achieve high TFE yields without any observable byproducts. This low-temperature method offers a safer and more sustainable alternative to traditional high-temperature processes for TFE production, which involve hazardous byproducts and complex handling. We also demonstrated that various chemical reactions using freshly generated TFE, including thiol addition, trifluorovinylation, radical addition, amination, alcohol addition, and polymerization, can be performed, extending the utility of this approach. Moreover, a continuous flow process for the conversion of HFC-125 to TFE at room temperature was achieved without cryogenic equipment. This dual-purpose solution addresses both environmental sustainability of fluorochemicals and the growing demand for fluoropolymers in various industries.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112580"},"PeriodicalIF":4.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability 提高生物利用度的姜黄素制剂的药代动力学研究和关键的再评价

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-03 DOI: 10.1016/j.isci.2025.112575

Maurice A.G.M. Kroon , Hanneke W.M. van Laarhoven , Eleonora L. Swart , Olaf van Tellingen , E. Marleen Kemper

{"title":"A pharmacokinetic study and critical reappraisal of curcumin formulations enhancing bioavailability","authors":"Maurice A.G.M. Kroon , Hanneke W.M. van Laarhoven , Eleonora L. Swart , Olaf van Tellingen , E. Marleen Kemper","doi":"10.1016/j.isci.2025.112575","DOIUrl":"10.1016/j.isci.2025.112575","url":null,"abstract":"<div><div>This independent crossover study assessed curcumin bioavailability and excretion in nine healthy males receiving three formulations (AOV, Longvida, and NovaSOL) at about 570 mg, while AOV was also tested at 2280 mg, with and without piperine. Plasma levels of unconjugated curcumin remained below 2 nM in most cases, including high-dose AOV and piperine combinations. NovaSOL achieved the highest levels (6.7–38 nM at 30 min), but these rapidly declined and were still 100-fold lower than concentrations used <em>in vitro</em> to show biological effects. Curcumin conjugates exceeded 10 nM with all formulations, particularly NovaSOL, which showed 100-fold higher levels. Fecal recovery mainly included unconjugated curcuminoids and was high, except for NovaSOL, suggesting better intestinal absorption. However, even when using a formulation with enhanced uptake, plasma levels of unconjugated curcumin remained minimal. Piperine addition provided no benefit. The findings underscore that bioavailability claims should be based on unconjugated curcumin and not on its poorly membrane permeable conjugates.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112575"},"PeriodicalIF":4.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced dry reforming of methane over nickel catalysts supported on zirconia coated mesoporous silica 氧化锆包覆介孔二氧化硅负载镍催化剂上甲烷干重整的增强

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-03 DOI: 10.1016/j.isci.2025.112582

Yi Zhong , Yuhao Peng , Hao Gu , Shan Zhang , Feng Ryan Wang , Wei Xiao , Hulei Yu , Dong Gu

{"title":"Enhanced dry reforming of methane over nickel catalysts supported on zirconia coated mesoporous silica","authors":"Yi Zhong , Yuhao Peng , Hao Gu , Shan Zhang , Feng Ryan Wang , Wei Xiao , Hulei Yu , Dong Gu","doi":"10.1016/j.isci.2025.112582","DOIUrl":"10.1016/j.isci.2025.112582","url":null,"abstract":"<div><div>Dry reforming of methane (DRM) offers a sustainable route to convert CH<sub>4</sub> and CO<sub>2</sub> into syngas, addressing both greenhouse gas emissions and energy demand. However, catalyst deactivation due to sintering and coking limits practical applications. In this work, we developed a mesoporous Ni-based catalyst (Ni/ZrSBA-15-OH) featuring abundant Ni-ZrO<sub>2</sub> interfaces and small Ni nanoparticles (5.6 nm) confined within a stable silica framework. This catalyst showed excellent performance, achieving 80% CH<sub>4</sub> and 87% CO<sub>2</sub> conversions at 750°C, with minimal coke formation (0.4 mg g<sub>cat</sub><sup>−1</sup> h<sup>−1</sup>) and high durability (1.3% CH<sub>4</sub> conversion loss over 20 h). Advanced characterizations (X-ray absorption spectroscopy [XAS], transmission electron microscopy [TEM], H<sub>2</sub>-temperature programmed reduction [H<sub>2</sub>-TPR], and temperature-programmed surface reaction [TPSR]) revealed that the metal-oxide interface enhances the activation of reactants and stabilizes active sites. Density functional theory (DFT) calculations confirmed that the Ni-ZrO<sub>2</sub> interface increases the energy barrier for CH∗ dehydrogenation, effectively suppressing carbon deposition. This study provides a rational strategy for designing structurally robust and coke-resistant Ni-based catalysts for efficient DRM.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112582"},"PeriodicalIF":4.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoporous polydopamine@CeO2 nanoparticles for photoacoustic-guided photothermal therapy in suppressing arthritis 介孔polydopamine@CeO2纳米颗粒用于光声引导光热治疗抑制关节炎

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-03 DOI: 10.1016/j.isci.2025.112576

Huazhen Liu , Jingjing Wang , Chenyang Zhao , Rui Zhang , Ming Wang , Yuxin Jiang , Desheng Sun , Yanglong Hou , Meng Yang

{"title":"Mesoporous polydopamine@CeO2 nanoparticles for photoacoustic-guided photothermal therapy in suppressing arthritis","authors":"Huazhen Liu , Jingjing Wang , Chenyang Zhao , Rui Zhang , Ming Wang , Yuxin Jiang , Desheng Sun , Yanglong Hou , Meng Yang","doi":"10.1016/j.isci.2025.112576","DOIUrl":"10.1016/j.isci.2025.112576","url":null,"abstract":"<div><div>Rheumatoid arthritis (RA) is characterized by poor oxygen supply and overproduction of reactive oxygen species (ROS), thereby exacerbating synovial inflammation. We synthesized MPDA@CeO<sub>2</sub> nanoparticles (NPs) by incorporating mesoporous polydopamine (MPDA) NPs and CeO<sub>2</sub> for photoacoustic imaging (PAI)-guided synergistic light-controlled PTT/oxygen-boosting/ROS-eliminating therapy. Upon irradiation with a near-infrared (NIR) laser, MPDA@CeO<sub>2</sub> NPs trigger photothermal conversion to eradicate inflammatory cells and release CeO<sub>2</sub>, which have a catalytic activity to eliminate ROS and release oxygen. The oxygen-release and ROS-depleting efficiency was simultaneously augmented by heat to further combat the harmful environment of inflammation. We validated the therapeutic effect of MPDA@CeO<sub>2</sub> <em>in vitro</em> and <em>in vivo</em>. We further applied multiwavelength PAI to observe the distribution of NPs and the change in oxygen saturation during the treatment process <em>in vivo</em>. The study highlights the therapeutic value of MPDA@CeO<sub>2</sub> in inhibiting arthritis in RA through imaging-guided synergistic therapy.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112576"},"PeriodicalIF":4.6,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental study on corrugated plate dryer in steam generator under hot working conditions 热工况下蒸汽发生器波纹板干燥机的实验研究

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-03 DOI: 10.1016/j.isci.2025.112581

Ru Li , Bo Wang , Gongqing Wang , Xuan Ye , Hanliang Bo , Ruifeng Tian , Xiong Wei

引用次数: 0

Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site 可溶性CD4通过靶向内体受体结合位点抑制埃博拉病毒感染

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-02 DOI: 10.1016/j.isci.2025.112573

Leah Liu Wang , Patrick Keiser , Derek Yang , Javier Seravalli , J.J. Patten , Brett Eaton , Dirk Anderson , Yi Liu , Michael R. Holbrook , Amos B. Smith III , Robert A. Davey , Shi-Hua Xiang

{"title":"Soluble CD4 inhibits Ebola virus infection by targeting endosomal receptor-binding site","authors":"Leah Liu Wang , Patrick Keiser , Derek Yang , Javier Seravalli , J.J. Patten , Brett Eaton , Dirk Anderson , Yi Liu , Michael R. Holbrook , Amos B. Smith III , Robert A. Davey , Shi-Hua Xiang","doi":"10.1016/j.isci.2025.112573","DOIUrl":"10.1016/j.isci.2025.112573","url":null,"abstract":"<div><div>Human CD4 (cluster of differentiation 4) is well known as the primary receptor for human immunodeficiency virus (HIV) entry into the cells. The virus binds to CD4 molecules to induce a conformational change in the viral glycoprotein (GP) gp120, which exposes the co-receptor binding site for coreceptors CCR5 or CXCR4. The co-receptor binding then leads to membrane fusion for viral entry. Since the CD4 molecule has a high affinity for gp120, soluble CD4 (sCD4) and CD4-mimetic small molecules (CD4mcs) have been extensively studied as potential inhibitors for HIV infection. Surprisingly, we have found that human sCD4 and some CD4mcs are able to inhibit Ebola virus (EBOV) infection. Evidence is provided that the compounds block viral entry by targeting the GP binding site for the endosomal receptor Niemann-Pick C1 (NPC1). This finding reveals virus-receptor binding similarities between two remote viruses (HIV and EBOV) and suggests new possibilities for EBOV entry inhibitors.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112573"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144089101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust generalization of tuning to self-induced sensation 调谐到自我诱导感觉的鲁棒泛化

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-02 DOI: 10.1016/j.isci.2025.112563

Rozana Ovsepian , David Souto , Alexander C. Schütz

引用次数: 0

p21, ccng1, foxo3b, and fbxw7 contribute to p53-dependent cell cycle arrest P21、ccng1、foxo3b和fbxw7参与p53依赖性细胞周期阻滞

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-02 DOI: 10.1016/j.isci.2025.112558

Jun Wang , Zhang Li , Holly R. Thomas , Ke Fan , Robert G. Thompson , Yongjie Ma , David Crossman , Bradley K. Yoder , John M. Parant

{"title":"p21, ccng1, foxo3b, and fbxw7 contribute to p53-dependent cell cycle arrest","authors":"Jun Wang , Zhang Li , Holly R. Thomas , Ke Fan , Robert G. Thompson , Yongjie Ma , David Crossman , Bradley K. Yoder , John M. Parant","doi":"10.1016/j.isci.2025.112558","DOIUrl":"10.1016/j.isci.2025.112558","url":null,"abstract":"<div><div>p53 is a transcription factor and important tumor suppressor gene, yet its mechanism of tumor suppression remains unclear. While PUMA/BBC3, NOXA/PMAIP1, and p21/CDKN1A regulate apoptosis and cell-cycle arrest, zebrafish lacking <em>puma</em>, <em>noxa</em>, and <em>p21</em> do not develop cancer, suggesting additional p53 targets contribute to tumor suppression. We show that p53 can still induce cell-cycle arrest in the absence of p21, either following DNA damage or mdm2 loss, implicating other transcriptional target in p53-dependent cell-cycle arrest. We conducted a cross-species analysis to identify 137 conserved p53-upregulated genes. Our analysis also stresses the importance of ortholog to paralog analysis across species, since in many cases the paralog but not ortholog in differing species is p53 dependent. Using a CRISPR-Cas9 G0 “crispant” screen in <em>mdm2</em>, <em>puma</em>, <em>noxa</em>, and <em>p21</em> quadruple knockout zebrafish, we identified <em>ccng1</em>, <em>fbxw7</em>, and <em>foxo3b</em> that are involved in <em>p53</em>-dependent cell-cycle arrest.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112558"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward understanding the complexity of long-duration energy storage siting in high renewable power grids 旨在了解高可再生电网中长时间储能选址的复杂性

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-02 DOI: 10.1016/j.isci.2025.112571

David L. Cole , Sourabh Dalvi , Victor M. Zavala , Omar J. Guerra

引用次数: 0

Color-selective numerosity adaptation depends on the automatic categorization of colored information 颜色选择数适应依赖于颜色信息的自动分类

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-05-02 DOI: 10.1016/j.isci.2025.112572

Paolo A. Grasso , Giovanni Anobile , Massimo Gurioli , Guido M. Cicchini , Roberto Arrighi

{"title":"Color-selective numerosity adaptation depends on the automatic categorization of colored information","authors":"Paolo A. Grasso , Giovanni Anobile , Massimo Gurioli , Guido M. Cicchini , Roberto Arrighi","doi":"10.1016/j.isci.2025.112572","DOIUrl":"10.1016/j.isci.2025.112572","url":null,"abstract":"<div><div>Numerosity perception is subject to adaptation, but this effect is greatly reduced when adaptor and test differ in color. This color-selectivity has been interpreted as evidence of automatic categorization of color-defined numerical information. However, some argue it instead demonstrates the non-numerical nature of numerosity adaptation. According to this idea numerosity adaptation is a byproduct of low-level filtering of spatial and chromatic information. Here, we contrasted these two perspectives by probing numerosity adaptation and its selectivity to color after equating stimuli in terms of their probability to be filtered out and by directly testing the role of categorization mechanisms in the genesis of color-selective adaptation behaviors. Our results confirm that numerosity adaptation does not depend on the filtering out of visual information and suggest that its selectivity for color genuinely reflects the visual system’s ability to automatically parse between categories when these are defined by salient visual attributes like color.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"Article 112572"},"PeriodicalIF":4.6,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0