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Identification of the client-binding site on the Golgi membrane protein adaptor Vps74/yGOLPH3 高尔基膜蛋白接头Vps74/yGOLPH3客户端结合位点的鉴定

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113494

Agnieszka M. Lesniak , Ziyun Ye , David K. Banfield

引用次数: 0

Efficient inference, training, and fine-tuning of protein language models 蛋白质语言模型的高效推理、训练和微调

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113495

Muhammed Hasan Çelik , Xiaohui Xie

引用次数: 0

Proprioception impacts body perception in healthy aging – Insights from a psychophysical and computational approach 本体感觉影响健康衰老的身体感知-来自心理物理和计算方法的见解

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113481

Gaia Risso , Marion Bieri , Tommaso Bertoni , Isabella Martinelli , Giulio Mastria , Loredana Catinari , Lara Allet , Andrea Serino , Michela Bassolino

{"title":"Proprioception impacts body perception in healthy aging – Insights from a psychophysical and computational approach","authors":"Gaia Risso , Marion Bieri , Tommaso Bertoni , Isabella Martinelli , Giulio Mastria , Loredana Catinari , Lara Allet , Andrea Serino , Michela Bassolino","doi":"10.1016/j.isci.2025.113481","DOIUrl":"10.1016/j.isci.2025.113481","url":null,"abstract":"<div><div>The way we perceive our body and its dimensions depends on how our brain combines multisensory information. As the human sensory system declines with age, we hypothesize that body perception may change during aging. We investigated this hypothesis by comparing body ownership (BO) and upper limb perceived dimensions (mBR) in young and older individuals (>65 years). We used computational and psychophysical methods to quantify alterations in mBR and BO, and modeled their relationship with sensorimotor and cognitive factors. Results revealed altered body perception in healthy older adults, with significant underestimation in arm dimensions and increased feeling of ownership over an incongruent virtual hand, incorporating it into their motor plans. Reduced abilities in localizing one’s own body in space (i.e., proprioception) emerged as a common factor influencing both BO and mBR. These findings pave the way for stimulation strategies to maintain or restore body perception in aging.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113481"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-cell multiomics reveals multiple adipogenic pathways and diverse multilineage specializations during embryonic fat tail morphogenesis 单细胞多组学揭示了胚胎脂肪尾形态发生过程中的多种脂肪形成途径和多种多谱系特化

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113496

Jiangang Han , Sijia Ma , Qiuxia Wei , Zhengwei Zhao , Yuhetian Zhao , Yabin Pu , Qianjun Zhao , Xiaohong He , Yuehui Ma , David E. MacHugh , Lin Jiang

{"title":"Single-cell multiomics reveals multiple adipogenic pathways and diverse multilineage specializations during embryonic fat tail morphogenesis","authors":"Jiangang Han , Sijia Ma , Qiuxia Wei , Zhengwei Zhao , Yuhetian Zhao , Yabin Pu , Qianjun Zhao , Xiaohong He , Yuehui Ma , David E. MacHugh , Lin Jiang","doi":"10.1016/j.isci.2025.113496","DOIUrl":"10.1016/j.isci.2025.113496","url":null,"abstract":"<div><div>Embryonic adipogenesis remains one of the least understood aspects of adipose biology in mammals due to time sensitivity, limited tissue volume, and ethical concerns. Here, we uniquely applied single-cell multi-omics sequencing to the developing adipose tissues of fat-tailed sheep, characterized by genetically determined, significant fat deposition in the tail during embryogenesis. Our dataset spans all stages of adipogenesis (E50 to E80), revealing three major cellular origins of fat deposition: progenitor and stem cells, connective tissue progenitors, and vascular smooth muscle cells. By integrating scRNA-seq, snATAC-seq, and functional validation, we identified key enhancer-driven gene regulatory networks (eGRNs) governing adipogenesis, with <em>DBI</em> emerging as a critical regulator through its interaction with PPARG. Additionally, we delineated developmental trajectories and unique eGRNs underlying angiogenesis, osteogenesis, chondrogenesis, and myogenesis associated with fat formation. Our findings provide novel insights into embryonic adipogenesis in mammals and reveal critical regulons governing lineage specialization.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113496"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-radical degradation mechanism on ZnO quantum dots/hollow-sphere g-C3N4 S-scheme heterojunction photocatalysts for tetracycline degradation ZnO量子点/空心球g- c3n4s型异质结光催化剂降解四环素的非自由基降解机理

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113500

Zhiwei Meng , Zirui Peng , Yupeng Yan , Qin Zhang , Yang Li

{"title":"Non-radical degradation mechanism on ZnO quantum dots/hollow-sphere g-C3N4 S-scheme heterojunction photocatalysts for tetracycline degradation","authors":"Zhiwei Meng , Zirui Peng , Yupeng Yan , Qin Zhang , Yang Li","doi":"10.1016/j.isci.2025.113500","DOIUrl":"10.1016/j.isci.2025.113500","url":null,"abstract":"<div><div>Photocatalytic technology is currently one of the most effective methods for removing tetracycline (TC) from the environment; however, the underlying photocatalytic mechanism remains unclear. In this study, zinc oxide quantum dots (ZnO-QDs)/hollow-sphere g-C<sub>3</sub>N<sub>4</sub> (CNHS) S-scheme heterojunction photocatalysts were synthesized for the photocatalytic degradation of tetracycline. Experimental results showed that the 7% ZnO-QDs/CNHS photocatalyst exhibited excellent TC degradation efficiency, with a removal rate of 80.2% within 15 min. Through free radical conversion pathway analysis, singlet oxygen (<sup>1</sup>O<sub>2</sub>) was identified as the primary active species responsible for tetracycline degradation. Further calculations indicated that the combination of holes (h<sup>+</sup>) and superoxide radicals (O<sub>2</sub><sup>−</sup>) produces <sup>1</sup>O<sub>2</sub>, accounting for 83.28% of the total contribution. These findings provide theoretical support for <sup>1</sup>O<sub>2</sub> as the primary active species in pollutant degradation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113500"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145155861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A single low-dimensional neural component of spinal motor neuron activity explains force generation across repetitive isometric tasks 脊髓运动神经元活动的单一低维神经成分解释了重复性等距任务中的力产生

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113483

Hélio V. Cabral , J. Greig Inglis , Elmira Pourreza , Milena A. Dos Santos , Caterina Cosentino , David O’Reilly , Ioannis Delis , Francesco Negro

{"title":"A single low-dimensional neural component of spinal motor neuron activity explains force generation across repetitive isometric tasks","authors":"Hélio V. Cabral , J. Greig Inglis , Elmira Pourreza , Milena A. Dos Santos , Caterina Cosentino , David O’Reilly , Ioannis Delis , Francesco Negro","doi":"10.1016/j.isci.2025.113483","DOIUrl":"10.1016/j.isci.2025.113483","url":null,"abstract":"<div><div>Low-dimensional control is thought to underlie spinal motor neuron activity, with low-frequency oscillations in common synaptic inputs serving as the primary determinant of muscle force production. Here, we used principal-component analysis and factor analysis to investigate the role of low-dimensional motor unit components in force production during repetitive isometric tasks with similar force profiles. In both individual and synergistic human muscles, the first motor unit component explained most of the variance in smoothed discharge rates and showed higher correlations with force oscillations than the second component. Additionally, the first component, but not the second, remained highly consistent across trials. A non-linear network-information framework further confirmed these findings, revealing high motor unit network density in the first component across all muscles. These results suggest that during isometric contractions, force oscillations are primarily driven by a single dominant shared synaptic input to spinal motor neuron activity.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113483"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Previously unrecognized diversity of far-red light-using terrestrial green algae and cyanobacteria 利用陆生绿藻和蓝藻的远红光的以前未被认识到的多样性

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113486

Pa-Yu Chen , Jui-Tse Ko , Tzu-Ling Chen , Ming-Yang Ho

引用次数: 0

NovumRNA: Accurate prediction of non-canonical tumor antigens from RNA sequencing data NovumRNA：从RNA测序数据中准确预测非典型肿瘤抗原

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113448

Markus Ausserhofer , Dietmar Rieder , Manuel Facciolla , Raphael Gronauer , Giorgia Lamberti , Rebecca Lisandrelli , Serena Pellegatta , Zlatko Trajanoski , Francesca Finotello

{"title":"NovumRNA: Accurate prediction of non-canonical tumor antigens from RNA sequencing data","authors":"Markus Ausserhofer , Dietmar Rieder , Manuel Facciolla , Raphael Gronauer , Giorgia Lamberti , Rebecca Lisandrelli , Serena Pellegatta , Zlatko Trajanoski , Francesca Finotello","doi":"10.1016/j.isci.2025.113448","DOIUrl":"10.1016/j.isci.2025.113448","url":null,"abstract":"<div><div>Non-canonical tumor-specific antigens (ncTSAs) can expand the pool of targets for cancer immunotherapy, but require robust and comprehensive computational pipelines for their prediction. Here, we present NovumRNA, a fully automated Nextflow pipeline for predicting different classes of ncTSAs from patients’ RNA sequencing data. We extensively benchmarked NovumRNA using publicly available and newly generated datasets, demonstrating the robustness of its analytical modules and predictions. NovumRNA analysis of RNA-seq data from colorectal cancer organoids and patients’ tumor samples revealed comparable ncTSA potential for microsatellite stable and unstable tumors and candidate therapeutic targets for patients with low tumor mutational burden. Finally, our investigation of glioblastoma cell lines demonstrated increased ncTSAs burden upon indisulam treatment, and detection by NovumRNA of therapy-induced ncTSAs, which we could validate experimentally. These findings underscore the potential of NovumRNA for identifying synergistic drugs and novel therapeutic targets for immunotherapy, which could ultimately extend its benefit to a broader patient population.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113448"},"PeriodicalIF":4.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An economic and environmental evaluation of Taiwan’s manure to energy applications 台湾粪肥能源利用之经济与环境评价

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113492

Chih-Chun Kung , Shuyin Hu , Tsung-Ju Lee , Juan Li

引用次数: 0

Low-hysteresis highly reversible topological magnetized elastomer for robotic tactile 机器人触觉用低滞后高可逆拓扑磁化弹性体

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-03 DOI: 10.1016/j.isci.2025.113501

Ziyin Xiang , Shengbin Li , Yuanzhao Wu , Zhiyi Gao , Qi Zhang , Hongfei Hou , Jinyun Liu , Zidong He , Xiaohui Yi , Baoru Bian , Yiwei Liu , Jie Shang , Run-Wei Li

引用次数: 0