iScience最新文献_第6页

Erratum: Opportunities and challenges for people-centered multi-hazard early warning systems: Perspectives from the Global South. 勘误：以人为本的多灾种预警系统的机遇和挑战：来自全球南方的观点。

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 eCollection Date: 2025-06-20 DOI: 10.1016/j.isci.2025.112784

Mirianna Budimir, Robert Šakić-Trogrlić, Cinthia Almeida, Miguel Arestegui, Orlando Chuquisengo Vásquez, Abel Cisneros, Monica Cuba Iriarte, Adama Dia, Leon Lizon, Giorgio Madueño, Alioune Ndiaye, Miluska Ordoñez Caldas, Tamanna Rahman, Bikram RanaTharu, Alpha Sall, Dharam Uprety, Chris Anderson, Colin McQuistan

引用次数: 0

All-optical tuning of ultrahigh Q-factor microsphere resonators with graphite coating 石墨涂层超高q因子微球谐振器的全光调谐

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112822

Zhaofeng Kang , Binbin Yang , Jiacheng Liu , Yang Wang , Di Tang , Lei Zhang , Keyi Wang , Yu Yang

引用次数: 0

Rewards and punishments help humans overcome biases against cooperation partners assumed to be machines 奖励和惩罚帮助人类克服对被认为是机器的合作伙伴的偏见

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112833

Kinga Makovi , Jean-François Bonnefon , Mayada Oudah , Anahit Sargsyan , Talal Rahwan

引用次数: 0

Majority illusion drives the spontaneous emergence of alternative states in common-pool resource games with network-based information 在基于网络信息的公共资源博弈中，多数错觉驱动了替代状态的自发出现

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112831

Nicolas Schrama , Andrew R. Tilman , Vítor V. Vasconcelos

引用次数: 0

A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055. 一项评估豪猪抑制剂AZD5055的安全性、耐受性和药代动力学的i期研究。

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 eCollection Date: 2025-06-20 DOI: 10.1016/j.isci.2025.112602

Xiao-Hong Zhou, Susanne Prothon, Engin Liathdale, Nicola Ferrari, Kebria Hezaveh, Zhi Liu, Szilard Nemes, Joachim Almquist, Michael L Williams, Olami Sobande, Christer Gottfridsson, Bernadette R Gochuico, Adam Platt, Zach Brohawn, Maria G Belvisi, Ronald Goldwater, Ellinor Hornberg, Caroline A Owen

{"title":"A phase 1 study evaluating the safety, tolerability, and pharmacokinetics of the porcupine inhibitor, AZD5055.","authors":"Xiao-Hong Zhou, Susanne Prothon, Engin Liathdale, Nicola Ferrari, Kebria Hezaveh, Zhi Liu, Szilard Nemes, Joachim Almquist, Michael L Williams, Olami Sobande, Christer Gottfridsson, Bernadette R Gochuico, Adam Platt, Zach Brohawn, Maria G Belvisi, Ronald Goldwater, Ellinor Hornberg, Caroline A Owen","doi":"10.1016/j.isci.2025.112602","DOIUrl":"10.1016/j.isci.2025.112602","url":null,"abstract":"<p><p>Excessive Wnt signaling contributes to the development of fibrotic diseases and cancer. Here, we report the findings of a phase 1 study evaluating AZD5055, an orally administered porcupine inhibitor, which inhibits Wnt signaling. The primary objective was to evaluate the safety and tolerability of AZD5055 in healthy volunteers. Secondary and exploratory objectives were the pharmacokinetics and pharmacodynamics of AZD5055, respectively. Sixty healthy volunteers were randomized to receive placebo or AZD5055 in single ascending doses of 7, 20, or 40 mg (part 1), or multiple ascending doses of 5, 15, or 20 mg once daily over 14 consecutive days of dosing (Part 2). AZD5055 was safe and well tolerated in both study parts. AZD5055 exposure increased dose-proportionally with a pharmacokinetic profile enabling once daily dosing. AZD5055 effectively inhibited Wnt signaling in skin, hair follicles, and serum samples. Thus, AZD5055 has therapeutic potential in Wnt-driven fibrotic diseases and cancers.</p>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 6","pages":"112602"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12177174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced reverse zoonotic potential and immune evasion by omicron JN.1 variant 组粒JN.1变异体增强反向人畜共患病潜能和免疫逃避

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112824

Jiaxin Hu , Fuwen Zan , Yixin He , Xiuyuan Ou , Xiaolu Tang , Yan Liu , Xing Lu , Pei Li , Zhixia Mu , Siwen Dong , Yahan Chen , Lin Tan , Mengmeng Cao , Pinghuang Liu , Terrence Tsz-Tai Yuen , Jian Lu , Zhaohui Qian

{"title":"Enhanced reverse zoonotic potential and immune evasion by omicron JN.1 variant","authors":"Jiaxin Hu , Fuwen Zan , Yixin He , Xiuyuan Ou , Xiaolu Tang , Yan Liu , Xing Lu , Pei Li , Zhixia Mu , Siwen Dong , Yahan Chen , Lin Tan , Mengmeng Cao , Pinghuang Liu , Terrence Tsz-Tai Yuen , Jian Lu , Zhaohui Qian","doi":"10.1016/j.isci.2025.112824","DOIUrl":"10.1016/j.isci.2025.112824","url":null,"abstract":"<div><div>SARS-CoV-2 infects not only humans but also animals, posing reverse zoonotic risks. As SARS-CoV-2 rapidly evolves, JN.1 has become dominant globally. In this study, we determined the susceptibility of XBB.1.16, EG.5.1, BA.2.86, and JN.1 to 27 different animal angiotensin-converting enzyme 2 (ACE2) orthologs using pseudoviruses, and found that JN.1 displayed substantially higher overall reverse zoonotic risk potential compared to other variants except for EG.5.1. Live virus infection experiments further confirmed higher infectivity of JN.1 than BA.2.86. Mechanistic analyses revealed that L455S might be responsible for substantial increase in overall fusogenecity and infectivity by lowering S protein thermostability. Additionally, we also found that L455S mutation enhanced immune evasion of SARS-CoV-2, and XBB breakthrough infection increased levels of neutralization antibodies against JN.1. Together, our findings offer a better mechanistic understanding of CoV entry, host range, evolution, and immunogenicity and highlight the importance of surveillance of susceptible hosts to prevent potential outbreaks.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 7","pages":"Article 112824"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization 结合光诱导聚集和生物素接近标记涉及早期α-突触核蛋白寡聚的内溶酶体蛋白

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112823

Maxime Teixeira , Razan Sheta , Dylan Musiol , Vetso Ranjakasoa , Jérémy Loehr , Jean-Philippe Lambert , Abid Oueslati

{"title":"Combining light-induced aggregation and biotin proximity labeling implicates endolysosomal proteins in early α-synuclein oligomerization","authors":"Maxime Teixeira , Razan Sheta , Dylan Musiol , Vetso Ranjakasoa , Jérémy Loehr , Jean-Philippe Lambert , Abid Oueslati","doi":"10.1016/j.isci.2025.112823","DOIUrl":"10.1016/j.isci.2025.112823","url":null,"abstract":"<div><div>Alpha-synuclein (α-syn) aggregation is a defining feature of Parkinson’s disease (PD) and related synucleinopathies. Despite significant research efforts focused on understanding α-syn aggregation mechanisms, the early stages of this process remain elusive, largely due to limitations in experimental tools that lack the temporal resolution to capture these dynamic events. Here, we introduce UltraID-LIPA, an innovative platform that combines the light-inducible protein aggregation (LIPA) system with the UltraID proximity-dependent biotinylation assay to identify α-syn-interacting proteins and uncover key mechanisms driving its oligomerization. UltraID-LIPA successfully identified 38 α-syn-interacting proteins, including both established and previously unreported candidates, highlighting the accuracy and robustness of the approach. Notably, a strong interaction with endolysosomal and membrane-associated proteins was observed, supporting the hypothesis that interactions with membrane-bound organelles are pivotal in the early stages of α-syn aggregation. This powerful platform provides new insights into dynamic protein aggregation events, enhancing our understanding of synucleinopathies and other proteinopathies.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 7","pages":"Article 112823"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A systems approach to sustainable finance: Actors, influence mechanisms, and potentially virtuous cycles of sustainability 可持续金融的系统方法：行动者、影响机制和可持续发展的潜在良性循环

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112785

Beatrice Crona , Garry Peterson , Megan Meacham , Giorgio Parlato , Steven J. Lade , Juan C. Rocha , Victor Galaz

{"title":"A systems approach to sustainable finance: Actors, influence mechanisms, and potentially virtuous cycles of sustainability","authors":"Beatrice Crona , Garry Peterson , Megan Meacham , Giorgio Parlato , Steven J. Lade , Juan C. Rocha , Victor Galaz","doi":"10.1016/j.isci.2025.112785","DOIUrl":"10.1016/j.isci.2025.112785","url":null,"abstract":"<div><div>Over the past decade, corporate investors have increasingly recognized that responsible environmental and social practices are essential to long-term financial success. Despite growing interest, corporate practices remain largely unchanged, and planetary trends are deeply concerning. This review applies a systems analysis lens to understand how financial sector structures and actors influence sustainability outcomes, often in counterproductive ways. Key barriers include the lack of science-based metrics, poor integration of environmental risks, and limited capacity to evaluate complex system dynamics. Current financial practices frequently miss or misinterpret systemic sustainability risks. We identify three critical areas where collaboration between sustainability science and finance is urgently needed: (1) translating scientific insights into financial decision contexts, (2) supporting science-based corporate sustainability reporting, and (3) strengthening environmental impact assessment. Systems thinking helps clarify where financial leverage can drive meaningful, cross-scale change—an essential step toward aligning capital flows with long-term ecological resilience and sustainability goals.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 7","pages":"Article 112785"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144489662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment model of blast injury: A narrative review 爆炸损伤评价模型：综述

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112830

Rui Liang , Hong Wang , Junhong Gao , Jianmin Wang , Wenjuan Zhang , Airong Qian

{"title":"Assessment model of blast injury: A narrative review","authors":"Rui Liang , Hong Wang , Junhong Gao , Jianmin Wang , Wenjuan Zhang , Airong Qian","doi":"10.1016/j.isci.2025.112830","DOIUrl":"10.1016/j.isci.2025.112830","url":null,"abstract":"<div><div>Craniocerebral and pulmonary injuries are primary blast-induced damages, assessed via numerical simulations, animal models, and postmortem human surrogates (PMHS). Recent years, the successful development of shock wave cell models and organoid models has provided new research directions for evaluation of blast injuries. Particularly human-derived organoids that can highly simulating the structure and function of human organs, significantly enhancing the physiological relevance of the models. Additionally, AI-based models (machine/deep learning) show promise in blast injury prediction and assessment. This review systematically summarizes the biological effects of explosive shock waves, the application of conventional assessment models and their limitations, and emerging technologies—cell/organoid models and AI applications. The utilization of cell models, human-derived organoid models, and AI models for the assessment of blast-induced biological injuries and subsequent research holds significant importance for understanding the cellular mechanisms of injury, protective research, and injury warning systems.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 7","pages":"Article 112830"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms 环境因素能够广泛干扰营养寿命延长模式

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-06-06 DOI: 10.1016/j.isci.2025.112827

Sainan Li , Nicole L. Stuhr , Fasih Ahsan , Yifei Zhou , Armen Yerevanian , Jen Rotti , Khoi Dao , Mohit Jain , Alexander A. Soukas

{"title":"Environmental factors capable of broadly interfering with nutritional lifespan extension paradigms","authors":"Sainan Li , Nicole L. Stuhr , Fasih Ahsan , Yifei Zhou , Armen Yerevanian , Jen Rotti , Khoi Dao , Mohit Jain , Alexander A. Soukas","doi":"10.1016/j.isci.2025.112827","DOIUrl":"10.1016/j.isci.2025.112827","url":null,"abstract":"<div><div>Despite being principally prescribed to treat type 2 diabetes, biguanides, especially metformin and phenformin, have been shown to extend lifespan and healthspan in preclinical models. Although there have been conflicting results in studies involving rodents and humans, consistent evidence indicates metformin and phenformin’s ability to significantly extend lifespan in <em>Caenorhabditis elegans</em>. We find that variation in agar from lot-to-lot or from different manufacturers influences metformin’s ability to extend lifespan in diverse <em>Caenorhabditis</em> species. Using unbiased metabolomics and genetics, we traced the ability of certain agars to interfere with metformin-prompted lifespan extension to differences in glucose, dipeptide, and trace element levels. These compounds act directly in the worm, independently of the bacterial food source, preventing longevity through action downstream of longevity effectors <em>skn-1</em> and AMPK. In contrast, phenformin prompts robust lifespan extension in the face of environmental changes and exhibits broad positive effects in aging across genetically diverse <em>Caenorhabditis</em> species.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 7","pages":"Article 112827"},"PeriodicalIF":4.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0