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TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism TLX3在小脑发育过程中调控CGN祖细胞增殖，其功能障碍可导致自闭症
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111260
Surendran Parvathy , Budhaditya Basu , Suresh Surya , Rahul Jose , Vadakkath Meera , Paul Ann Riya , Nair Pradeep Jyothi , Rajendran Sanalkumar , Viviane Praz , Nicolò Riggi , Biju Surendran Nair , Kamalesh K. Gulia , Mukesh Kumar , Balachandran Krishnamma Binukumar , Jackson James
{"title":"TLX3 regulates CGN progenitor proliferation during cerebellum development and its dysfunction can lead to autism","authors":"Surendran Parvathy ,&nbsp;Budhaditya Basu ,&nbsp;Suresh Surya ,&nbsp;Rahul Jose ,&nbsp;Vadakkath Meera ,&nbsp;Paul Ann Riya ,&nbsp;Nair Pradeep Jyothi ,&nbsp;Rajendran Sanalkumar ,&nbsp;Viviane Praz ,&nbsp;Nicolò Riggi ,&nbsp;Biju Surendran Nair ,&nbsp;Kamalesh K. Gulia ,&nbsp;Mukesh Kumar ,&nbsp;Balachandran Krishnamma Binukumar ,&nbsp;Jackson James","doi":"10.1016/j.isci.2024.111260","DOIUrl":"10.1016/j.isci.2024.111260","url":null,"abstract":"<div><div><em>Tlx3</em>, a master regulator of the fate specification of excitatory neurons, is primarily known to function in post-mitotic cells. Although we have previously identified TLX3 expression in the proliferating granule neuron progenitors (GNPs) of cerebellum, its primary role is unknown. Here, we demonstrate that the dysfunction of <em>Tlx3</em> from the GNPs significantly reduced its proliferation through regulating anti-proliferative genes. Consequently, the altered generation of GNPs resulted in cerebellar hypoplasia, patterning defects, granule neuron-Purkinje ratio imbalance, and aberrant synaptic connections in the cerebellum. This altered cerebellar homeostasis manifested into a typical autism-like behavior in mice with motor, and social function disabilities. We also show the presence of <em>TLX3</em> variants with uncharacterized mutations in human cases of autism spectrum disorder (ASD). Altogether, our study establishes <em>Tlx3</em> as a critical gene involved in developing GNPs and that its deletion from the early developmental stage culminates in autism.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111260"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining health equity: A modern US perspective 定义健康公平：现代美国视角
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111326
Kristen R. Prentice , Marie Beitelshees , Andrew Hill , Charles H. Jones
{"title":"Defining health equity: A modern US perspective","authors":"Kristen R. Prentice ,&nbsp;Marie Beitelshees ,&nbsp;Andrew Hill ,&nbsp;Charles H. Jones","doi":"10.1016/j.isci.2024.111326","DOIUrl":"10.1016/j.isci.2024.111326","url":null,"abstract":"<div><div>Health equity is a concept that has gained increasing attention and relevance in the context of the COVID-19 pandemic, which has exposed and exacerbated the health disparities and inequities among different population groups in the United States. This article aims to provide a comprehensive and critical overview of the historical, theoretical, and empirical foundations of health equity, as well as the challenges and opportunities for advancing it in the modern US society. By adopting an interdisciplinary and intersectional approach, and by drawing on literature from public health, sociology, economics, and human rights, we argue that health equity is not only a matter of fairness and justice, but also a strategic and pragmatic goal for improving the health and well-being of the entire nation. Here, we propose a modern definition of health equity for the US context, and conclude with some recommendations for policy, practice, and research to promote health equity in the US</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111326"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sustainable and smart rail transit based on advanced self-powered sensing technology 基于先进自供电传感技术的可持续智能轨道交通
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111306
Hongjie Tang , Lingji Kong , Zheng Fang , Zutao Zhang , Jianhong Zhou , Hongyu Chen , Jiantong Sun , Xiaolong Zou
{"title":"Sustainable and smart rail transit based on advanced self-powered sensing technology","authors":"Hongjie Tang ,&nbsp;Lingji Kong ,&nbsp;Zheng Fang ,&nbsp;Zutao Zhang ,&nbsp;Jianhong Zhou ,&nbsp;Hongyu Chen ,&nbsp;Jiantong Sun ,&nbsp;Xiaolong Zou","doi":"10.1016/j.isci.2024.111306","DOIUrl":"10.1016/j.isci.2024.111306","url":null,"abstract":"<div><div>As rail transit continues to develop, expanding railway networks increase the demand for sustainable energy supply and intelligent infrastructure management. In recent years, advanced rail self-powered technology has rapidly progressed toward artificial intelligence and the internet of things (AIoT). This review primarily discusses the self-powered and self-sensing systems in rail transit, analyzing their current characteristics and innovative potentials in different scenarios. Based on this analysis, we further explore an IoT framework supported by sustainable self-powered sensing systems including device nodes, network communication, and platform deployment. Additionally, technologies about cloud computing and edge computing deployed in railway IoT enable more effective utilization. The deployed intelligent algorithms such as machine learning (ML) and deep learning (DL) can provide comprehensive monitoring, management, and maintenance in railway environments. Furthermore, this study explores research in other cross-disciplinary fields to investigate the potential of emerging technologies and analyze the trends for future development in rail transit.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111306"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiative cooling technology with artificial intelligence 人工智能辐射冷却技术
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111325
Yeongju Jung , Seung Hwan Ko
{"title":"Radiative cooling technology with artificial intelligence","authors":"Yeongju Jung ,&nbsp;Seung Hwan Ko","doi":"10.1016/j.isci.2024.111325","DOIUrl":"10.1016/j.isci.2024.111325","url":null,"abstract":"<div><div>As sustainable thermal management becomes a global priority, the development of radiative cooling (RC) technology has recently emerged as a promising solution. Simultaneously, recent advent of artificial intelligence (AI) offers the potential to revolutionize current research in sustainable cooling strategies. This article discusses the advancement of radiative cooling technology through the integration of AI, tackling the challenging issues arising from the conventional approach and offering strategic solutions to address global issues. AI, capable of mimicking or exceeding human capabilities through various algorithms, enables the efficient optimization of RC structures. Moreover, integrating AI with advanced RC technologies, which have the potential to surpass traditional RC configurations and applications but are still in the early stages, can further accelerate progress in the field of RC. Hence, AI-driven RC technologies will contribute to addressing the increasingly prevalent environmental challenges, further being a leading solution for next-generation sustainable thermal managements as these technologies continue to mature.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111325"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Linking new information to a short-lasting memory trace induces consolidation in the hippocampus 将新信息与短暂记忆痕迹联系起来可诱导海马体巩固记忆
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111320
Andressa Gabriela Soliani , Jessica Santos Baptista , Beatriz Gangale Muratori , Lucia Armelin Correa , Suzete Maria Cerutti
{"title":"Linking new information to a short-lasting memory trace induces consolidation in the hippocampus","authors":"Andressa Gabriela Soliani ,&nbsp;Jessica Santos Baptista ,&nbsp;Beatriz Gangale Muratori ,&nbsp;Lucia Armelin Correa ,&nbsp;Suzete Maria Cerutti","doi":"10.1016/j.isci.2024.111320","DOIUrl":"10.1016/j.isci.2024.111320","url":null,"abstract":"<div><div>Novelty often influences the retention of nearby weak and transient memory traces, yet its precise role in shaping long-term memory storage remains elusive. Here, we demonstrate that a short-lasting memory is stabilized into a long-lasting one when new information is linked to the weak mnemonic trace in rats, resulting in the formation of long-term memories that are recalled together. An increased overlap between neuronal ensembles and <em>de novo</em> protein synthesis in the dorsal CA1 region of the hippocampus (dCA1) mediates this process. This intricate interconnectedness relies on both temporal and contextual relations between experiences, enhancing the adaptive value of memory consolidation. Finally, this phenomenon is negatively affected by aging, which is associated with reduced ensemble size after novelty exposure and diminished overlap between ensembles in aged dCA1. These findings provide valuable insights into the selectivity and malleability of memory consolidation and its decline during aging.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111320"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling 从采样到模拟：系统病理生理学建模中的单细胞多组学
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111322
Alexandra Manchel , Michelle Gee , Rajanikanth Vadigepalli
{"title":"From sampling to simulating: Single-cell multiomics in systems pathophysiological modeling","authors":"Alexandra Manchel ,&nbsp;Michelle Gee ,&nbsp;Rajanikanth Vadigepalli","doi":"10.1016/j.isci.2024.111322","DOIUrl":"10.1016/j.isci.2024.111322","url":null,"abstract":"<div><div>As single-cell omics data sampling and acquisition methods have accumulated at an unprecedented rate, various data analysis pipelines have been developed for the inference of cell types, cell states and their distribution, state transitions, state trajectories, and state interactions. This presents a new opportunity in which single-cell omics data can be utilized to generate high-resolution, high-fidelity computational models. In this review, we discuss how single-cell omics data can be used to build computational models to simulate biological systems at various scales. We propose that single-cell data can be integrated with physiological information to generate organ-specific models, which can then be assembled to generate multi-organ systems pathophysiological models. Finally, we discuss how generic multi-organ models can be brought to the patient-specific level thus permitting their use in the clinical setting.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111322"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142654719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets 脂肪移植诱导的溶血磷脂酰胆碱通过影响 ACC 神经元周围网的功能障碍来调节痛觉减退
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111274
Juan Li , Zhen Li , Yanbo Liu , Yijing Li , Yanqiong Wu , Anne Manyande , Zhixiao Li , Hongbing Xiang
{"title":"Lysophosphatidylcholine induced by fat transplantation regulates hyperalgesia by affecting the dysfunction of ACC perineuronal nets","authors":"Juan Li ,&nbsp;Zhen Li ,&nbsp;Yanbo Liu ,&nbsp;Yijing Li ,&nbsp;Yanqiong Wu ,&nbsp;Anne Manyande ,&nbsp;Zhixiao Li ,&nbsp;Hongbing Xiang","doi":"10.1016/j.isci.2024.111274","DOIUrl":"10.1016/j.isci.2024.111274","url":null,"abstract":"<div><div>The pathogenesis of hyperalgesia is complex and can lead to poor clinical treatment. Our study revealed that epididymal white adipose tissue (eWAT) from spared nerve injury (SNI) mice is involved in the occurrence of hyperalgesia after adipose tissue transplantation. We also showed that lysophosphatidylcholine (LPC) is enriched in the eWAT of SNI mice using non-targeted metabolomic analysis and verified that the levels of LPC in plasma and the anterior cingulate cortex (ACC) region increased following eWAT transplantation. Based on the immunohistochemistry results, we observed that LPC in the ACC region activated microglia via the TRPV1/CamkⅡ pathway. Meanwhile, the disruption of perineuronal nets (PNNs) around PV<sup>+</sup> neurons in ACC promoted hyperalgesia, and the loss of PNNs and PV<sup>+</sup> interneurons might be due to microglial phagocytosis. These findings elucidate the mechanism underlying hyperalgesia from the perspective of lipid metabolite LPC and PNNs and provide potential strategies for the treatment of hyperalgesia.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111274"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence 胶质母细胞瘤对纺锤体抑制剂的抗药性取决于 STAT3 和治疗诱导的衰老
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-05 DOI: 10.1016/j.isci.2024.111311
Natanael Zarco , Athanassios Dovas , Virginea de Araujo Farias , Naveen K.H. Nagaiah , Ashley Haddock , Peter A. Sims , Dolores Hambardzumyan , Christian T. Meyer , Peter Canoll , Steven S. Rosenfeld , Rajappa S. Kenchappa
{"title":"Resistance to spindle inhibitors in glioblastoma depends on STAT3 and therapy induced senescence","authors":"Natanael Zarco ,&nbsp;Athanassios Dovas ,&nbsp;Virginea de Araujo Farias ,&nbsp;Naveen K.H. Nagaiah ,&nbsp;Ashley Haddock ,&nbsp;Peter A. Sims ,&nbsp;Dolores Hambardzumyan ,&nbsp;Christian T. Meyer ,&nbsp;Peter Canoll ,&nbsp;Steven S. Rosenfeld ,&nbsp;Rajappa S. Kenchappa","doi":"10.1016/j.isci.2024.111311","DOIUrl":"10.1016/j.isci.2024.111311","url":null,"abstract":"<div><div>While mitotic spindle inhibitors specifically kill proliferating tumor cells without the toxicities of microtubule poisons, resistance has limited their clinical utility. Treating glioblastomas with the spindle inhibitors ispinesib, alisertib, or volasertib creates a subpopulation of therapy induced senescent cells that resist these drugs by relying upon the anti-apoptotic and metabolic effects of activated STAT3. Furthermore, these senescent cells expand the repertoire of cells resistant to these drugs by secreting an array of factors, including TGF<u>β</u>, which induce proliferating cells to exit mitosis and become quiescent—a state that also resists spindle inhibitors. Targeting STAT3 restores sensitivity to each of these drugs by depleting the senescent subpopulation and inducing quiescent cells to enter the mitotic cycle. These results support a therapeutic strategy of targeting STAT3-dependent therapy-induced senescence to enhance the efficacy of spindle inhibitors for the treatment of glioblastoma.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111311"},"PeriodicalIF":4.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Happy new ears: Rapid adaptation to novel spectral cues in vertical sound localization 快乐的新耳朵在垂直声音定位中快速适应新的频谱线索
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-04 DOI: 10.1016/j.isci.2024.111308
Cesare Parise , Monica Gori , Sara Finocchietti , Marc Ernst , Davide Esposito , Alessia Tonelli
{"title":"Happy new ears: Rapid adaptation to novel spectral cues in vertical sound localization","authors":"Cesare Parise ,&nbsp;Monica Gori ,&nbsp;Sara Finocchietti ,&nbsp;Marc Ernst ,&nbsp;Davide Esposito ,&nbsp;Alessia Tonelli","doi":"10.1016/j.isci.2024.111308","DOIUrl":"10.1016/j.isci.2024.111308","url":null,"abstract":"<div><div>Humans can adapt to changes in the acoustic properties of the head and exploit the resulting novel spectral cues for sound source localization. However, the adaptation rate varies across studies and is not associated with the aftereffects commonly found after adaptation in other sensory domains. To investigate the adaptation’ rate and measure potential aftereffects, our participants wore new-ears to alter the spectral cues for sound localization and underwent sensorimotor training to induce rapid adaptation. Within 20 min, our sensorimotor-training induced full adaptation to the new-ears, as demonstrated by changes in various performance indexes, including the localization gain, bias, and precision. Once the new ears were removed, participants displayed systematic aftereffects, evident as drop in the precision of localization lasting only a few trials. These results highlight the short-term plasticity of human spatial hearing, which is capable to quickly adapt to spectral perturbations and inducing large, yet short lived, aftereffects.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111308"},"PeriodicalIF":4.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combined effects of genetic background and diet on mouse metabolism and gene expression 遗传背景和饮食对小鼠新陈代谢和基因表达的综合影响
IF 4.6 2区 综合性期刊
iScience Pub Date : 2024-11-04 DOI: 10.1016/j.isci.2024.111323
Jordan N. Reed , Faten Hasan , Abhishek Karkar , Dhanush Banka , Jameson Hinkle , Preeti Shastri , Navya Srivastava , Steven C. Scherping , Sarah E. Newkirk , Heather A. Ferris , Bijoy K. Kundu , Sibylle Kranz , Mete Civelek , Susanna R. Keller
{"title":"Combined effects of genetic background and diet on mouse metabolism and gene expression","authors":"Jordan N. Reed ,&nbsp;Faten Hasan ,&nbsp;Abhishek Karkar ,&nbsp;Dhanush Banka ,&nbsp;Jameson Hinkle ,&nbsp;Preeti Shastri ,&nbsp;Navya Srivastava ,&nbsp;Steven C. Scherping ,&nbsp;Sarah E. Newkirk ,&nbsp;Heather A. Ferris ,&nbsp;Bijoy K. Kundu ,&nbsp;Sibylle Kranz ,&nbsp;Mete Civelek ,&nbsp;Susanna R. Keller","doi":"10.1016/j.isci.2024.111323","DOIUrl":"10.1016/j.isci.2024.111323","url":null,"abstract":"<div><div>In humans, dietary patterns impact weight and metabolism differentially across individuals. To uncover genetic determinants for differential dietary effects, we subjected four genetically diverse mouse strains to humanized diets (American, Mediterranean, vegetarian, and vegan) with similar macronutrient composition, and performed body weight, metabolic parameter, and RNA-seq analysis. We observed pronounced diet- and strain-dependent effects on weight, and triglyceride and insulin levels. Differences in fat mass, adipose tissue, and skeletal muscle glucose uptake, and gene expression changes in most tissues were strain-dependent. In visceral adipose tissue, ∼400 genes responded to diet in a strain-dependent manner, many of them in metabolite transport and lipid metabolism pathways and several previously identified to modify diet effects in humans. Thus, genetic background profoundly impacts metabolism, though chosen dietary patterns modify the strong genetic effects. This study paves the way for future mechanistic investigations into strain-diet interactions in mice and translation to precision nutrition in humans.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111323"},"PeriodicalIF":4.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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