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Flexible, large area preparable phase change PVA/P(ILs-AM)/SSD films for electromagnetic wave absorption and infrared stealth 用于电磁波吸收和红外隐身的柔性、大面积可制备相变 PVA/P(ILs-AM)/SSD 薄膜

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112366

Yi Liang , Lechun Deng , Bingcheng Luo , Limin Zhang , Kai Tao , Xuexiang Li , Qiang Chen , Hongjing Wu

{"title":"Flexible, large area preparable phase change PVA/P(ILs-AM)/SSD films for electromagnetic wave absorption and infrared stealth","authors":"Yi Liang , Lechun Deng , Bingcheng Luo , Limin Zhang , Kai Tao , Xuexiang Li , Qiang Chen , Hongjing Wu","doi":"10.1016/j.isci.2025.112366","DOIUrl":"10.1016/j.isci.2025.112366","url":null,"abstract":"<div><div>Electromagnetic wave absorption (EMA) and infrared stealth are two vital ways of anti-detection that it is a great challenge to develop a compatible material which is low-cost, easy to prepare and exhibits excellent mechanical properties. Here, multifunctional films are prepared using one-pot method by wrapping phase change crystals Na<sub>2</sub>SO<sub>4</sub>·10H<sub>2</sub>O (SSD) with dual-network molecular chains. The phase change behavior with high enthalpy (150.8 J/g) at a temperature of 31.2°C can absorb and release latent heat, which endows films with the ability to regulate temperature dynamically. The dual-network acts as phase change buffer-medium to prevent leakage, with excellent mechanical properties, and also provides abundant conductivity and polarization loss. The results show that the films significantly reduce thermal radiation temperature of the target in low-medium temperatures while achieving excellent EMA properties (the effective absorption bandwidth reaches 6 GHz at 1.9 mm). It provides an idea for the development of multi-band compatible functional materials.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112366"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112364

Marc Nater , Michael Brügger , Virginia Cecconi , Paulo Pereira , Geo Forni , Hakan Köksal , Despoina Dimakou , Michael Herbst , Anna Laura Calvanese , Giulia Lucchiari , Christoph Schneider , Tomas Valenta , Maries van den Broek

{"title":"Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver","authors":"Marc Nater , Michael Brügger , Virginia Cecconi , Paulo Pereira , Geo Forni , Hakan Köksal , Despoina Dimakou , Michael Herbst , Anna Laura Calvanese , Giulia Lucchiari , Christoph Schneider , Tomas Valenta , Maries van den Broek","doi":"10.1016/j.isci.2025.112364","DOIUrl":"10.1016/j.isci.2025.112364","url":null,"abstract":"<div><div>The liver is an important metastatic organ that contains many innate immune cells, yet little is known about their role in anti-metastatic defense. We investigated how invariant natural killer T (iNKT) cells influence colorectal cancer-derived liver metastasis using different models in immunocompetent mice. We found that hepatic iNKT cells promote metastasis by creating a supportive niche for disseminated cancer cells. Mechanistically, iNKT cells respond to disseminating cancer cells by producing the fibrogenic cytokines interleukin-4 (IL-4) and IL-13 in a T cell receptor-independent manner. Selective abrogation of IL-4 and IL-13 sensing in hepatic stellate cells prevented their transdifferentiation into extracellular matrix-producing myofibroblasts, which hindered metastatic outgrowth of disseminated cancer cells. This study highlights a novel tumor-promoting axis driven by iNKT cells in the initial stages of metastasis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112364"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Participatory science in urban soil research: A framework for overcoming challenges and expanding public engagement 城市土壤研究中的参与式科学：克服挑战和扩大公众参与的框架

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112361

Anna A. Paltseva

{"title":"Participatory science in urban soil research: A framework for overcoming challenges and expanding public engagement","authors":"Anna A. Paltseva","doi":"10.1016/j.isci.2025.112361","DOIUrl":"10.1016/j.isci.2025.112361","url":null,"abstract":"<div><div>Urban soils play a crucial role in supporting city sustainability, including green infrastructure, food production, water regulation, and climate resilience. Yet their complexity, compounded by environmental risks, pose challenges for research and policy. This article presents a participatory science framework that engages communities in soil monitoring and management through co-designed projects, educational outreach, and simplified data collection protocols. By integrating digital tools and real-time mapping, the framework enhances data accuracy while fostering environmental stewardship. Grounded in interdisciplinary collaboration, the framework connects scientific research, technological support, community engagement, and policy advocacy to improve urban soil health. Demonstrated through case studies and practical strategies, this approach builds capacity for sustained community involvement and equitable environmental decision-making. The broader significance lies in the framework’s ability to foster reciprocal relationships between scientists and communities, where shared knowledge, action, and responsibility strengthen urban soil stewardship.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112361"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143847412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cost trajectory of hydrogen fuel cell technology in China 中国氢燃料电池技术的成本轨迹

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112359

Xue Wang , Li-Wei Fan , Hongyan Zhang , Peng Zhou

引用次数: 0

Adaptive singular spectral decomposition hybrid framework with quadratic error correction for wind power prediction

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-06 DOI: 10.1016/j.isci.2025.112360

Chunliang Mai , Lixin Zhang , Omar Behar , Xue Hu , Xuewei Chao

{"title":"Adaptive singular spectral decomposition hybrid framework with quadratic error correction for wind power prediction","authors":"Chunliang Mai , Lixin Zhang , Omar Behar , Xue Hu , Xuewei Chao","doi":"10.1016/j.isci.2025.112360","DOIUrl":"10.1016/j.isci.2025.112360","url":null,"abstract":"<div><div>High-precision wind power forecasting is essential for grid scheduling and renewable energy utilization. Wind data’s nonlinear, stochastic, and multi-scale characteristics create prediction challenges. This study proposes a hybrid model integrating adaptive improved singular spectrum analysis (ISSA), optimized bidirectional temporal convolutional network–bidirectional long short-term memory (BiTCN-BiLSTM) networks, and AdaBoost ensemble learning. Adaptive ISSA provides parameter-free, data-driven modal decomposition to reduce noise. Hybrid strategy-enhanced dung beetle optimization (OTDBO) fine-tunes hyperparameters of BiTCN-BiLSTM, and AdaBoost dynamically corrects errors, significantly improving robustness. Tests using seasonal datasets from Dabancheng wind farm (China) show substantial performance improvement (mean absolute error [MAE] reduced by 45.4%, root-mean-square error (RMSE) by 47.6%, <em>p</em> < 0.001), and training time reduced by 12.1%–21.3%. This method offers accurate, scalable forecasting for reliable renewable energy integration.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112360"},"PeriodicalIF":4.6,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ensuring low-emission electricity purchasing requires a broader systems perspective

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112349

Lissy Langer , Kenneth Bruninx , Anders Bjørn , Lukas Barner , Julien Lavalley , Hadi Vatankhah Ghadim , Rasmus Bramstoft

{"title":"Ensuring low-emission electricity purchasing requires a broader systems perspective","authors":"Lissy Langer , Kenneth Bruninx , Anders Bjørn , Lukas Barner , Julien Lavalley , Hadi Vatankhah Ghadim , Rasmus Bramstoft","doi":"10.1016/j.isci.2025.112349","DOIUrl":"10.1016/j.isci.2025.112349","url":null,"abstract":"<div><div>Introducing electricity purchase conditions in renewable fuel regulations and carbon accounting is a controversial issue in the US and Europe. We argue that their impact must be assessed considering demand flexibility, local grid conditions, and overlapping policy instruments such as emissions trading schemes and renewable portfolio standards. The introduction of more stringent requirements has a significant impact on companies' reported progress in reducing indirect emissions. In addition, we currently lack reliable carbon intensity data with sufficient temporal and spatial granularity outside the US and Europe. Assessing hydrogen imports should consider strategic behavior. In summary, a broader systems perspective is needed to analyze the impact of electricity purchase conditions on markets, prices, and emissions, integrating voluntary actions to decarbonize hard-to-abate sectors under increasing renewable energy shares. This will have implications not only for the (re)design and integration of certificate markets for renewable electricity but also for renewable fuels and carbon.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112349"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112354

Yao-Nan Liu , Qiu-Wen Wang , Si-Yao Lu , Wei Shen , Chongye Guo , Zhikai Xing , Chang Li , Shan Sun , Sen-Fang Sui , Shuangli Mi , Fred H. Gage , Jun Yao

{"title":"Synaptotagmin-7 deficit causes insulin hypoactivity and contributes to behavioral alterations in mice","authors":"Yao-Nan Liu , Qiu-Wen Wang , Si-Yao Lu , Wei Shen , Chongye Guo , Zhikai Xing , Chang Li , Shan Sun , Sen-Fang Sui , Shuangli Mi , Fred H. Gage , Jun Yao","doi":"10.1016/j.isci.2025.112354","DOIUrl":"10.1016/j.isci.2025.112354","url":null,"abstract":"<div><div>Synaptotagmin-7 (Syt7) KO mice show diurnal fluctuations of mania- and depression-like behavioral abnormalities. Although GluN2B-NMDAR hypoactivity has been shown to be involved in the induction of mania-like behaviors of the Syt7 KO mice in the dark phase, the reasons for the depression-like behaviors in the light phase and behavioral fluctuation remain unknown. Here, we show that bipolar I disorder (BDI)-patient-induced pluripotent stem cell (iPSC)-derived islet-like organoids exhibited Syt7-dependent insulin secretion defects; moreover, Syt7-deficiency-induced insulin hyposecretion generated depression-like behaviors in Syt7 KO mice in the light phase. Furthermore, pancreatic insulin secretion and neuronal activity showed opposite diurnal patterns, in which the Syt7-deficiency-induced disequilibrium induced periodic antagonistic shifts in the mania- and depression-like behaviors. Finally, using RNA sequencing (RNA-seq) analysis, we explored downstream pathways that might underlie the diurnal fluctuation of behaviors. Therefore, Syt7-deficiency-induced insulin hypoactivity contributed to light-phase depression-like behaviors and diurnal behavioral fluctuations in the mice.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112354"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroactive steroids activate membrane progesterone receptors to induce sex specific effects on protein kinase activity

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112352

Abigail H.S. Lemons , Briana Murphy , Jake S. Dengler , Seda Salar , Paul A. Davies , Joshua L. Smalley , Stephen J. Moss

{"title":"Neuroactive steroids activate membrane progesterone receptors to induce sex specific effects on protein kinase activity","authors":"Abigail H.S. Lemons , Briana Murphy , Jake S. Dengler , Seda Salar , Paul A. Davies , Joshua L. Smalley , Stephen J. Moss","doi":"10.1016/j.isci.2025.112352","DOIUrl":"10.1016/j.isci.2025.112352","url":null,"abstract":"<div><div>Neuroactive steroids (NAS), which are synthesized in the brain from progesterone, exert potent effects on behavior and are used to treat postpartum depression, yet how these compounds induce sustained modifications in neuronal activity are ill-defined. Here, we examined the efficacy of NAS for membrane progesterone receptors (mPRs) δ and ε, members of a family of GPCRs for progestins that are expressed in the CNS. NAS increase PKC activity via the G<sub>q</sub> activation of mPRδ with EC50s between 3 and 11nM. In contrast, they activate G<sub>s</sub> via mPRε to potentiate PKA activity with similar potencies. NAS also induced the rapid internalization of only mPRδ. In the forebrain of female mice, mPRδ expression levels were 8-fold higher than in males. Consistent with this, the activation of PKC by NAS was evident in acute brain slices from female mice. Collectively, our results suggest that NAS may exert sex-specific effects on intracellular signaling in the brain via the activation of mPRs.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112352"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical property evaluation and wear optimization of LM13 MMC reinforced with AlTiVZrCrMo high entropy alloy

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112356

Selvaraj Rameshkumar , Nachimuthu Radhika , Sundaram Ragunath , Animesh Kumar Basak

{"title":"Mechanical property evaluation and wear optimization of LM13 MMC reinforced with AlTiVZrCrMo high entropy alloy","authors":"Selvaraj Rameshkumar , Nachimuthu Radhika , Sundaram Ragunath , Animesh Kumar Basak","doi":"10.1016/j.isci.2025.112356","DOIUrl":"10.1016/j.isci.2025.112356","url":null,"abstract":"<div><div>The increasing demand for lightweight materials with superior mechanical and tribological properties has driven the development of high-entropy alloys (HEAs) reinforced aluminum metal matrix composites (AMMCs). A 10 wt. % of ball-milled equiatomic AlTiVZrCrMo HEA is reinforced into LM 13 alloy using stir casting to enhance its mechanical properties and wear performance. The homogeneous HEA dispersion and grain refinement of the Al/HEA composite improves the microhardness, compressive strength, and tensile strength by 37.6%, 73.3%, and 47.8%, respectively, over the LM 13 alloy. The Pin-on-disc tribometer is used to evaluate the wear rate of the Al/HEA composite. The process parameters such as applied load, sliding distance, and sliding velocity are optimized using response surface methodology. Analysis of variance reveals that applied load is the influential parameter, followed by sliding distance and sliding velocity. Worn surface morphology reveals predominant wear mechanisms, including grooves, delamination, and oxide layer formation, offering insight into the composite’s wear behavior.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112356"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-04-04 DOI: 10.1016/j.isci.2025.112355

Ruilong Xia , Chenxi Jin , Siying Fei , Tingting Dong , Ting Wen , Fengting Zhu , Yunxin Shi , Qian Zhou , Yong Tao , Changgeng Peng

{"title":"Therapeutic restoration of miR-96 prevents hearing loss in mice through modulation of noise-induced and genetic pathways","authors":"Ruilong Xia , Chenxi Jin , Siying Fei , Tingting Dong , Ting Wen , Fengting Zhu , Yunxin Shi , Qian Zhou , Yong Tao , Changgeng Peng","doi":"10.1016/j.isci.2025.112355","DOIUrl":"10.1016/j.isci.2025.112355","url":null,"abstract":"<div><div>Hearing loss often arises from impairments in multiple genes, complicating therapeutic development. MicroRNAs, as master regulators, offer promising targets for complex diseases. We explored <em>miR-96</em>’s roles in hair cell (HC) function and noise-induced hearing loss (NIHL), finding that <em>miR-96</em><sup>−/−</sup>, not <em>miR-96</em><sup><em>+/−</em></sup>, mice exhibited progressive hearing loss due to gene regulatory network dysregulation from <em>miR-96</em> loss in HCs not spiral ganglion neurons (SGNs). Viral-mediated delivery of <em>miR-96</em> into the inner ear partially rescued hearing of <em>miR-96</em><sup>−/−</sup> mice. Tamoxifen-induced depletion of <em>miR-96</em> in adult <em>UBC</em><sup><em>CreERT2/+</em></sup>; <em>miR-96</em><sup><em>fl/fl</em></sup> mice led to hearing loss, with <em>Bach2</em>, <em>Gabra2</em>, <em>Gabra4</em>, and <em>Grk1</em> upregulation and <em>Tnn</em>, <em>Col11a1</em>, <em>Gjb3</em>, and <em>Hnf4a</em> downregulation. Furthermore, noise trauma reduced <em>miR-96</em>, altering <em>Bach2</em>, <em>Bcl2l1</em>, <em>Slc26a9</em>, <em>Gabrb1</em>, <em>Grk1</em>, <em>Nos2</em>, and <em>Cyp1a1</em> expression, whereas <em>miR-96</em> overexpression protected hearing against noise by reversing the expression of <em>Bach2</em>, <em>Bcl2l1</em>, and <em>Cyp1a1</em>. Our findings underscore <em>miR-96</em>’s essential role in adult hearing maintenance and NIHL prevention, presenting it as a promising therapeutic target.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 5","pages":"Article 112355"},"PeriodicalIF":4.6,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143870653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0