iScience最新文献_第5页

An extension module for a two-photon microscope enables flexible in vivo imaging and all-optical physiology 扩展模块的双光子显微镜，使灵活的体内成像和全光学生理

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-07 DOI: 10.1016/j.isci.2025.113525

Ryosuke F. Takeuchi , Risa Ishida , Riki Kamaguchi , Masatoshi Nishimura , Keigo Tsutsumi , Kei N. Ito , Shota Adachi , Keisuke Isobe , Fumitaka Osakada

{"title":"An extension module for a two-photon microscope enables flexible in vivo imaging and all-optical physiology","authors":"Ryosuke F. Takeuchi , Risa Ishida , Riki Kamaguchi , Masatoshi Nishimura , Keigo Tsutsumi , Kei N. Ito , Shota Adachi , Keisuke Isobe , Fumitaka Osakada","doi":"10.1016/j.isci.2025.113525","DOIUrl":"10.1016/j.isci.2025.113525","url":null,"abstract":"<div><div>Two-photon imaging is essential for revealing the structure, function, and interaction of various cell types. However, conventional two-photon microscopes have limitations in sample accessibility and optogenetic manipulation during imaging. Here, we present Ex2p/Ex2pO, an open-source extension module that adds an objective lens rotation axis and one-photon optical stimulation synchronized with the non-imaging intervals of resonant scanning to a two-photon microscope. The Ex2p/Ex2pO can be seamlessly integrated into existing microscopes by simply replacing the standard objective lens assembly without any modifications. It enables imaging of curved structures while maintaining the subject’s natural posture and simultaneous imaging and one-photon stimulation with low crosstalk between stimulation and fluorescent light. We demonstrate one-photon stimulation during two-photon imaging of mice behaving in a virtual reality environment and pluripotent stem cell-derived cortical organoids. Thus, Ex2p/Ex2pO expands the versatility to investigate neural circuit motifs in behaving animals and organoids, enabling all-optical physiology in existing two-photon imaging systems.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113525"},"PeriodicalIF":4.1,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current evidence and challenges of multitarget anti-angiogenic agents for glioblastoma: Results from clinical trials 多靶点抗血管生成药物治疗胶质母细胞瘤的当前证据和挑战：临床试验结果

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-07 DOI: 10.1016/j.isci.2025.113521

Xinliang Liu , Zhigang Chen , Xin Wang , Pengwei Yan , Dan Zong , Wenjie Guo , Xia He

{"title":"Current evidence and challenges of multitarget anti-angiogenic agents for glioblastoma: Results from clinical trials","authors":"Xinliang Liu , Zhigang Chen , Xin Wang , Pengwei Yan , Dan Zong , Wenjie Guo , Xia He","doi":"10.1016/j.isci.2025.113521","DOIUrl":"10.1016/j.isci.2025.113521","url":null,"abstract":"<div><div>Glioblastoma (GBM) is a highly vascularized and aggressive brain tumor with a dismal prognosis. This systematic review critically appraises clinical evidence for multitarget anti-angiogenic agents, which inhibit pathways such as VEGFR, FGFR, and PDGFR. Most supporting data come from small, single-arm phase II trials or retrospective studies. Five challenges are highlighted: (i) translational shortcomings of current preclinical models, (ii) restriction of agent delivery by the blood-brain barrier (BBB), (iii) heterogeneity of tumor endothelial cells (TECs) driving intrinsic and adaptive resistance, (iv) angiogenic escape via vasculogenic mimicry (VM), and (v) a lack of consensus on late-line treatment for recurrent GBM (rGBM). Future research should prioritize robust biomarker development, brain-penetrant agents, strategies tailored to specific TEC subtypes, and disruption of VM to unlock the full therapeutic potential of anti-angiogenic agents in GBM. This review provides an evidence-based foundation and translational research guidance for clinicians and pharmaceutical researchers.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113521"},"PeriodicalIF":4.1,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment NRF2在癌细胞中的激活抑制肿瘤微环境的免疫浸润

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-06 DOI: 10.1016/j.isci.2025.113519

Huaichun Wen , Takafumi Suzuki , Anqi Zhang , Miu Sato , Mahiro Matsumoto , Yuka Takahashi , Yushi Takahashi , Masayuki Yamamoto

{"title":"NRF2 activation in cancer cells suppresses immune infiltration into the tumor microenvironment","authors":"Huaichun Wen , Takafumi Suzuki , Anqi Zhang , Miu Sato , Mahiro Matsumoto , Yuka Takahashi , Yushi Takahashi , Masayuki Yamamoto","doi":"10.1016/j.isci.2025.113519","DOIUrl":"10.1016/j.isci.2025.113519","url":null,"abstract":"<div><div>Clinical observations have revealed that NRF2 hyperactivation in cancer cells is often associated with immune suppression in the tumor microenvironment. However, it remains unclear whether NRF2 hyperactivation directly reduces immune cell infiltration into tumors. To address this question, we established a syngeneic mouse model using the transplantation of 3LL lung cancer-derived cells with either NRF2 hyperactivation via <em>Keap1</em> gene deletion or concomitant <em>Keap1-Nrf2</em> gene deletion. A series of flow cytometry, histological analysis, and comprehensive gene expression profiling demonstrated that immune cell infiltration was significantly reduced in KEAP1-deleted tumors, with a marked decrease in CD45-positive cells, particularly myeloid and monocytic populations. In contrast, concomitant deletion of NRF2 restored immune cell infiltration in the KEAP1-deleted tumors. These findings provide convincing lines of evidence that NRF2 activation in cancer cells suppresses immune cell infiltration into tumors. Our study sheds light on the mechanistic basis by which NRF2 activation contributes to cancer malignancy.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113519"},"PeriodicalIF":4.1,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors 雄性特异性gaba能神经元中sifamide依赖的突触可塑性是经验调节交配行为的基础

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113516

Tianmu Zhang (张天目) , Hongyu Miao (苗鸿钰) , Yutong Song (宋雨桐) , Zekun Wu (吴泽坤) , Woo Jae Kim (金佑宰김우재)

{"title":"SIFamide-dependent synaptic plasticity in male-specific GABAergic neurons underlies experience-modulated mating behaviors","authors":"Tianmu Zhang (张天目) , Hongyu Miao (苗鸿钰) , Yutong Song (宋雨桐) , Zekun Wu (吴泽坤) , Woo Jae Kim (金佑宰김우재)","doi":"10.1016/j.isci.2025.113516","DOIUrl":"10.1016/j.isci.2025.113516","url":null,"abstract":"<div><div><em>Drosophila melanogaster</em> relies on complex brain circuits and neuromodulation for experience-dependent sexual behavior, yet the role of neuropeptide signaling in behavioral refinement remains unclear. We investigate SIFamide (SIFa) and its receptor (SIFaR) in regulating male <em>Drosophila</em> sexual behavior. SIFaR is essential for these behaviors, particularly interval timing. Knockdown in fru-positive neurons impairs courtship index (CI) and mating duration (MD) but not copulation latency (CL). Critically, SIFaR in GABAergic mAL neurons (fru<sup>+</sup>, dsx<sup>−</sup>) specifically controls MD and CI, not CL. Additionally, SIFa signaling in mAL neurons of experienced males increases presynaptic terminals, indicating context-dependent synaptic plasticity. These results reveal a complex SIFa/SIFaR interaction with specific neurons in modulating male behavior. The distinct roles of SIFaR in fru-positive versus other neurons, alongside its plasticity function, provide new insights into neural mechanisms of context-dependent behavioral adaptation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113516"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor m1样巨噬细胞通过P2X4受体调控T细胞在结直肠癌中的浸润

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113517

Kun Zhou , Xintian Zhang , Yu Liang , Han Yao , Yichao Hou , Xingming Zhang , Leilei Du , Wenfeng Wang , Jianhua Wang , Xiangjun Meng

{"title":"M1-like macrophages regulate T cell infiltration in colorectal cancer through P2X4 receptor","authors":"Kun Zhou , Xintian Zhang , Yu Liang , Han Yao , Yichao Hou , Xingming Zhang , Leilei Du , Wenfeng Wang , Jianhua Wang , Xiangjun Meng","doi":"10.1016/j.isci.2025.113517","DOIUrl":"10.1016/j.isci.2025.113517","url":null,"abstract":"<div><div>Although tumor-associated macrophages (TAMs) play a critical immunomodulatory role in colorectal cancer (CRC), the mechanisms underlying their polarization remain unclear. This study identifies the P2X4 receptor (P2X4R) as a crucial mediator of M1-like polarization. During TAM induction in a controlled <em>in vitro</em> system using CRC cell-conditioned medium, we observed P2X4R-mediated calcium influx and subsequent mitochondrial dysfunction through immunofluorescence and mitochondrial assays. This dysfunction led to mitochondrial DNA release and subsequent activation of the cGAS-STING-IFNB1 pathway, driving M1-like polarization of TAMs. Flow cytometry demonstrated that P2X4R-expressing TAMs not only enhanced CD8<sup>+</sup> T cell survival and cytotoxicity <em>in vitro</em> but also augmented T cell responses in a syngeneic CRC mouse model. Clinically, reduced P2X4 expression in CRC tissues correlated with poorer prognosis. In conclusion, these findings identify the P2X4R as a key regulator of M1-like TAM polarization, representing a promising target to reprogram TAMs and suppress CRC progression.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113517"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disruption of the transsulfuration pathway by acute kidney injury causes intestinal damage 急性肾损伤破坏转硫途径可引起肠道损伤

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113511

Shunshun Jin , Charith U.B. Wijerathne , Yaw L. Siow , Karmin O

{"title":"Disruption of the transsulfuration pathway by acute kidney injury causes intestinal damage","authors":"Shunshun Jin , Charith U.B. Wijerathne , Yaw L. Siow , Karmin O","doi":"10.1016/j.isci.2025.113511","DOIUrl":"10.1016/j.isci.2025.113511","url":null,"abstract":"<div><div>Acute kidney injury (AKI) impairs intestinal function through oxidative stress. The transsulfuration pathway is essential for sulfur amino acid metabolism and antioxidant defense through glutathione biosynthesis. This study investigated how AKI caused intestinal injury and the mechanisms involved. AKI was induced in Sprague-Dawley rats through kidney ischemia (45 min)-reperfusion (24 h). AKI decreased intestinal glutathione (antioxidant) levels and compromised intestinal barrier function. Glutathione biosynthesis in mammals requires cysteine made through the reverse transsulfuration pathway, catalyzed by cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CSE). AKI decreased the expression of these enzymes in intestinal epithelium. AKI also altered gut microbiota composition and the expression of bacterial enzymes in the forward transsulfuration pathway, which could disrupt intestinal antioxidant defense. The inhibition of this pathway in gut epithelial cells reduced glutathione levels and tight junction protein expression. These results suggest that the disruption of the transsulfuration pathway impairs antioxidant defense, leading to intestinal barrier damage and dysbiosis in AKI.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113511"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated multi-dimensional comparison of proteomic profiles across 54 cancer cell lines 54种癌细胞系蛋白质组学特征的综合多维比较

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113514

Wenhao Shi , Tianlong He , Nan Wang , Annan Qian , Yuqiao Liu , Shaojun Tang , Yiying Zhu

{"title":"Integrated multi-dimensional comparison of proteomic profiles across 54 cancer cell lines","authors":"Wenhao Shi , Tianlong He , Nan Wang , Annan Qian , Yuqiao Liu , Shaojun Tang , Yiying Zhu","doi":"10.1016/j.isci.2025.113514","DOIUrl":"10.1016/j.isci.2025.113514","url":null,"abstract":"<div><div>Human cancer cell lines are essential model systems in biomedical research. We conducted multi-level proteomics analyses on 54 widely used cancer cell lines derived from various tissues using two prominent proteomics technologies: mass spectrometry (MS) and reverse-phase protein array (RPPA). Our analysis identified 10,088 proteins, 33,161 phosphorylation sites across 7,469 phosphoproteins, and 56,320 site-specific glycans on 14,228 glycosylation sites from 5,966 glycoproteins, along with 305 drug-relevant protein and phosphoprotein targets. Analysis of this rich dataset yielded numerous biological insights, including protein features that distinguish tissue origins and cell line-specific kinase activation patterns, reflecting signaling diversity across cancer types. These findings may inform therapeutic strategies and support rational model system selection. Additionally, MS and RPPA showed consistent fold-change estimation and provided complementary views of proteome and signaling variation. This comprehensive resource facilitates biomarker discovery, signaling analysis, and translational oncology research across diverse human tumor types.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113514"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Closed-loop carbon management strategies for climate and energy-resilient India 气候和能源弹性印度的闭环碳管理战略

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113509

Piyali Majumder , Arnab Dutta

{"title":"Closed-loop carbon management strategies for climate and energy-resilient India","authors":"Piyali Majumder , Arnab Dutta","doi":"10.1016/j.isci.2025.113509","DOIUrl":"10.1016/j.isci.2025.113509","url":null,"abstract":"<div><div>Climate change, primarily driven by excessive CO<sub>2</sub> emissions, poses urgent global challenges. India contributes over 2,600 Mt CO<sub>2</sub> annually, with ∼80% originating from hard-to-abate sectors, such as power, cement, petrochemical, chemical, and steel. This review highlights the importance of carbon capture, utilization, and storage (CCUS) and carbon dioxide removal (CDR) technologies as critical pathways to align India’s growth with climate goals. India prioritizes point-source capture from flue gases, reflecting its concentrated emission profile. Effective carbon management models must generate high-value marketable products, including fuels, fertilizers, aggregates, and construction materials, supporting a closed-loop carbon cycle. Mineralization pathways enable CO<sub>2</sub>-based building materials to strengthen Smart City and infrastructure initiatives, while CO<sub>2</sub>-derived fertilizers enhance agricultural productivity and food security. The manuscript also examines India’s emerging carbon market, recommending balanced compulsory and voluntary mechanisms, carbon credit incentives, and utilization-driven byproducts. Collectively, it provides an integrated CCUS framework for India that couples emission reduction with economic viability and offers scalable insights for other developing economies.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113509"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptomic analysis of phage-mammalian cell interaction reveals diverse phage immunobarcodes 噬菌体-哺乳动物细胞相互作用的转录组学分析揭示了不同的噬菌体免疫条形码

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113513

Caroline Munini Muema , Belinda Kibii , Mingyue Zhong , Xinfeng Li , Paulina Miernikiewicz , Heng Xue , Yiyao Wang , Raphael Nyaruaba , Krystyna Dąbrowska , Hongping Wei , Hang Yang

{"title":"Transcriptomic analysis of phage-mammalian cell interaction reveals diverse phage immunobarcodes","authors":"Caroline Munini Muema , Belinda Kibii , Mingyue Zhong , Xinfeng Li , Paulina Miernikiewicz , Heng Xue , Yiyao Wang , Raphael Nyaruaba , Krystyna Dąbrowska , Hongping Wei , Hang Yang","doi":"10.1016/j.isci.2025.113513","DOIUrl":"10.1016/j.isci.2025.113513","url":null,"abstract":"<div><div>The phage-mammalian cell interactome is an emerging research frontier essential for uncovering the diverse impacts phages may have on humans. Here, we investigate the crosstalk of six distinct <em>Acinetobacter baumannii</em> phages with A549 epithelial cells and RAW264.7 macrophages. Our findings indicate that phage internalization rate varies depending on the phage type and the cell line. Notably, podovirus phage demonstrates the highest rate of internalization, while myovirus phage exhibits the lowest. Internalized phages maintain significant activity against intracellular bacteria. RNA sequencing revealed that phage-treated A549 cells display anti-inflammatory transcriptional signatures (immunobarcodes). Conversely, macrophages treated with siphovirus phage CK02 or podovirus phage CK21 demonstrate an anti-inflammatory profile, while those treated with myovirus phage CK12 maintain a pro-inflammatory response. Moreover, both phage-treated cells exhibit the downregulation of cellular reproduction and proliferation pathways, pointing to underexplored dimensions of phage-mammalian cell interactions. Altogether, our findings highlight the complexity of phage effects on mammalian cells.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113513"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficient phenol removal by δ-MnO2 synthesized in situ on a self-supporting membrane 自支撑膜上原位合成δ-MnO2高效脱酚

IF 4.1 2区综合性期刊

iScience Pub Date : 2025-09-05 DOI: 10.1016/j.isci.2025.113482

Yi Liu

{"title":"Efficient phenol removal by δ-MnO2 synthesized in situ on a self-supporting membrane","authors":"Yi Liu","doi":"10.1016/j.isci.2025.113482","DOIUrl":"10.1016/j.isci.2025.113482","url":null,"abstract":"<div><div>Manganese oxides are effective environmental coupling oxidants for the conversion of phenol; however, previous research has mainly focused on their powdered rather than immobilized forms. To address this gap, the oxidative removal of phenol from aqueous solutions was investigated using δ-MnO<sub>2</sub>, which was synthesized <em>in situ</em> and immobilized on a tailorable self-supporting membrane carrier (MnO<sub>2</sub>/M). The Freundlich isotherm provided the best fit for adsorption, whereas Sips successfully indicated the highest adsorption capacity. Kinetic analyses showed that the pseudo-second-order and electron transfer control models represented the reaction dynamics, with intra-particle diffusion and liquid film diffusion playing crucial roles. Physicochemical calculations confirmed the exothermic and spontaneous nature of the reaction (ΔG = −31.65 kJ/mol; 298 K). This research also clarifies and elucidates the two-electron direct oxidative transfer processes involved in the oxidative transformation of phenol by the MnO<sub>2</sub>/H<sup>+</sup> heterogeneous system, establishing a framework for advancing environmental remediation using Mn-based materials.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 10","pages":"Article 113482"},"PeriodicalIF":4.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145107367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0