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Does malaria infection increase the risk of predation-related mortality during bird migration? 疟疾感染是否会增加鸟类迁徙过程中与捕食相关的死亡风险？

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111358

Laura Gangoso , Claudia Santamaría-Cervantes , Josué Martínez-de la Puente , María José Ruiz López , Jordi Figuerola

{"title":"Does malaria infection increase the risk of predation-related mortality during bird migration?","authors":"Laura Gangoso , Claudia Santamaría-Cervantes , Josué Martínez-de la Puente , María José Ruiz López , Jordi Figuerola","doi":"10.1016/j.isci.2024.111358","DOIUrl":"10.1016/j.isci.2024.111358","url":null,"abstract":"<div><div>The migratory culling hypothesis posits that infected individuals are less likely to survive long-distance migration due to physiological and behavioral effects, but this lacks empirical evidence. Here, we tested this hypothesis by sampling 357 passerines from 11 species during their autumn migration to wintering grounds in two different areas, i) at a stopover in southern Spain, and ii) in the Canary Islands, where they were drifted and preyed upon by Eleonora’s falcons while <em>en route</em> to the southern Sahara. Molecular detection of infections by <em>Plasmodium</em>, <em>Haemoproteus,</em> and <em>Leucocytozoon</em> was conducted on bird samples. A higher prevalence of both <em>Plasmodium</em> and <em>Haemoproteus</em> was observed in birds preyed upon by falcons. While a complete understanding of the mechanistic effects of haemosporidian infections on migration performance needs experimental validation, our approach suggests that infection reduces migration success by increasing mortality due to route deviations and/or predation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111358"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A rapid, affordable, and reliable method for profiling microbiome biomarkers from fecal images 快速、经济、可靠的粪便图像微生物组生物标记分析方法

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111310

Donghyeok Lee , Annemiek Maaskant , Huy Ngo , Roy C. Montijn , Jaco Bakker , Jan A.M. Langermans , Evgeni Levin

{"title":"A rapid, affordable, and reliable method for profiling microbiome biomarkers from fecal images","authors":"Donghyeok Lee , Annemiek Maaskant , Huy Ngo , Roy C. Montijn , Jaco Bakker , Jan A.M. Langermans , Evgeni Levin","doi":"10.1016/j.isci.2024.111310","DOIUrl":"10.1016/j.isci.2024.111310","url":null,"abstract":"<div><div>Human and veterinary healthcare professionals are interested in utilizing the gut-microbiome as a target to diagnose, treat, and prevent (gastrointestinal) diseases. However, the current microbiome analysis techniques are expensive and time-consuming, and data interpretation requires the expertise of specialists. Therefore, we explored the development and application of artificial intelligence technology for rapid, affordable, and reliable microbiome profiling in rhesus macaques (<em>Macaca mulatta</em>). Tailor-made learning algorithms were created by integrating digital images of fecal samples with corresponding whole-genome sequenced microbial profiles. These algorithms were trained to identify alpha-diversity (Shannon index), key microbial markers, and fecal consistency from the digital images of fecal smears. A binary classification strategy was applied to distinguish between samples with high and low diversity and presence or absence of selected bacterial genera. Our results revealed a successful proof of concept for “high and low” prediction of diversity, fecal consistency, and “present or absent” for selected bacterial genera.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111310"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective aqueous anion recognition in an anionic host 在阴离子主机中选择性识别水阴离子

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111348

Noa Bar Ziv , Chengwei Chen , Bryce da Camara , Ryan R. Julian , Richard J. Hooley

{"title":"Selective aqueous anion recognition in an anionic host","authors":"Noa Bar Ziv , Chengwei Chen , Bryce da Camara , Ryan R. Julian , Richard J. Hooley","doi":"10.1016/j.isci.2024.111348","DOIUrl":"10.1016/j.isci.2024.111348","url":null,"abstract":"<div><div>Water-soluble Fe<sub>4</sub>L<sub>4</sub><sup>4−</sup> cages can be synthesized in a multicomponent self-assembly process exploiting functionalized trigonal ligands, Fe<sup>II</sup> salts, and water-soluble sulfonated formylpyridine components. The cages are soluble in purely aqueous solution and display an overall 4− charge, but are capable of binding suitably sized non-coordinating anions in the host cavity despite their anionic nature. Anions such as PF<sub>6</sub><sup>−</sup> or AsF<sub>6</sub><sup>−</sup> occupy the internal cavity, whereas anions that are too small (BF<sub>4</sub><sup>−</sup>) or too large (NTf<sub>2</sub><sup>−</sup>) are not encapsulated. The external anionic charge and sterically blocked ligand cores limit the exchange rate of bound anions, as no exchange is seen over a period of weeks with the anion-filled cages, and internalization of added PF<sub>6</sub><sup>−</sup> by an empty cage takes multiple weeks, despite the strong affinity of the cavity for PF<sub>6</sub><sup>−</sup> ions. In the future, this recognition mechanism could be used to control release of anions for environmental applications.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111348"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidences from gut microbiome and habitat landscape indicate continued threat of extinction for the Hainan gibbon 来自肠道微生物组和栖息地景观的证据表明，海南长臂猿仍面临灭绝的威胁

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111352

Guangping Huang , Wei Li , Yun Liu , Jiang Zhou , Fuwen Wei

引用次数: 0

Berbamine prevents SARS-CoV-2 entry and transmission 小檗胺可预防 SARS-CoV-2 的进入和传播

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111347

Srikanth Sadhu , Sandeep Goswami , Ritika Khatri , Bharat Lohiya , Virendra Singh , Rahul Yadav , Vinayaka Das , Manas Ranjan Tripathy , Prabhanjan Dwivedi , Mitul Srivastava , Shailendra Mani , Shailendra Asthana , Sweety Samal , Amit Awasthi

{"title":"Berbamine prevents SARS-CoV-2 entry and transmission","authors":"Srikanth Sadhu , Sandeep Goswami , Ritika Khatri , Bharat Lohiya , Virendra Singh , Rahul Yadav , Vinayaka Das , Manas Ranjan Tripathy , Prabhanjan Dwivedi , Mitul Srivastava , Shailendra Mani , Shailendra Asthana , Sweety Samal , Amit Awasthi","doi":"10.1016/j.isci.2024.111347","DOIUrl":"10.1016/j.isci.2024.111347","url":null,"abstract":"<div><div>Effective antiviral drugs are essential to combat COVID-19 and future pandemics. Although many compounds show antiviral <em>in vitro</em> activity, only a few retain effectiveness <em>in vivo</em> against SARS-CoV-2. Here, we show that berbamine (Berb) is effective against SARS-CoV, MER-CoV, SARS-CoV-2 and its variants, including the XBB.1.16 variant. In hACE2.Tg mice, Berb suppresses SARS-CoV-2 replication through two distinct mechanisms: inhibiting spike-mediated viral entry and enhancing antiviral gene expression during infection. The administration of Berb, in combination with remdesivir (RDV), clofazimine (Clof) and fangchinoline (Fcn), nearly eliminated viral load and promoted recovery from acute SARS-CoV-2 infection and its variants. Co-housed mice in direct contact with either pre-treated or untreated infected mice exhibited negligible viral loads, reduced lung pathology, and decreased viral shedding, suggesting that Berb may effectively hinder virus transmission. This broad-spectrum activity positions Berb as a promising preventive or therapeutic option against betacoronaviruses.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111347"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Audience presence influences cognitive task performance in chimpanzees.

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 eCollection Date: 2024-11-15 DOI: 10.1016/j.isci.2024.111191

Christen Lin, Akiho Muramatsu, Shinya Yamamoto

引用次数: 0

Assessing the impact of armed conflict on the progress of achieving 17 sustainable development goals 评估武装冲突对实现 17 项可持续发展目标的影响

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-07 DOI: 10.1016/j.isci.2024.111331

Di Wang , Mengmeng Hao , Ning Li , Dong Jiang

引用次数: 0

The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights 三细胞连接蛋白 ILDR2 在肾小球疾病中的作用：表达模式与功能见解

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-07 DOI: 10.1016/j.isci.2024.111329

Florian Siegerist , Felix Kliewe , Elke Hammer , Paul Schakau , Joanne Ern Chi Soh , Claudia Weber , Maja Lindenmeyer , Simone Reichelt-Wurm , Vedran Drenic , Christos Chatziantoniou , Christos E. Chadjichristos , Yiying Zhang , Stefan Simm , Miriam C. Banas , Matthias Nauck , Uwe Völker , Nicole Endlich

{"title":"The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights","authors":"Florian Siegerist , Felix Kliewe , Elke Hammer , Paul Schakau , Joanne Ern Chi Soh , Claudia Weber , Maja Lindenmeyer , Simone Reichelt-Wurm , Vedran Drenic , Christos Chatziantoniou , Christos E. Chadjichristos , Yiying Zhang , Stefan Simm , Miriam C. Banas , Matthias Nauck , Uwe Völker , Nicole Endlich","doi":"10.1016/j.isci.2024.111329","DOIUrl":"10.1016/j.isci.2024.111329","url":null,"abstract":"<div><div>The tricellular tight junctions are crucial for the regulation of paracellular flux at tricellular junctions, where tricellulin (MARVELD2) and angulins (ILDR1, ILDR2, or LSR) are localized. The role of ILDR2 in podocytes, specialized epithelial cells in the kidney, is still unknown. We investigated the role of ILDR2 in glomeruli and its influence on blood filtration. Western blots, single-cell RNA sequencing (scRNA-seq), and superresolution microscopy showed a strong expression of ILDR2 in podocytes that colocalized with the podocyte-specific claudin CLDN5. Co-immunoprecipitation revealed that ILDR2 interacts with CLDN5. In glomerulopathies, induced by nephrotoxic serum and by desoxycorticosterone acetate (DOCA)-salt heminephrectomy, ILDR2 was strongly up-regulated. Furthermore, <em>Ildr2</em> knockout mice exhibited glomerular hypertrophy and decreased podocyte density. However, they did not develop effacement of podocyte foot processes or proteinuria. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomic analysis of isolated glomeruli showed an increase in matrix proteins, such as fibronectin and collagens. This suggests a protective role of ILDR2 in glomerulopathies.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111329"},"PeriodicalIF":4.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A lysosome-targeted fluorescent probe with large Stokes shift for visualizing biothiols in vivo and in vitro 具有大斯托克斯偏移的溶酶体靶向荧光探针，用于在体内和体外观察生物硫醇

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-07 DOI: 10.1016/j.isci.2024.111334

Taotao Zhao , Tong Zhang , Zijun Tao , Zhe Zhou , Xiaofeng Xia , Zhengjun Wu , Feiyi Wang , Jun Ren , Erfei Wang

引用次数: 0

Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis 肌骨质疏松症对胰腺癌患者生存期的影响：系统回顾与荟萃分析

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-07 DOI: 10.1016/j.isci.2024.111343

Xin Zhang , Licheng Wei , Jiangguo Li , Yuexia Deng , Wei Xu , Dongkui Chen , Xing Li

{"title":"Influence of myosteatosis on survival of patients with pancreatic cancer: A systematic review and meta-analysis","authors":"Xin Zhang , Licheng Wei , Jiangguo Li , Yuexia Deng , Wei Xu , Dongkui Chen , Xing Li","doi":"10.1016/j.isci.2024.111343","DOIUrl":"10.1016/j.isci.2024.111343","url":null,"abstract":"<div><div>The present meta-analysis aims to evaluate the impact of myosteatosis on overall survival (OS) and progression-free survival (PFS) in patients with pancreatic cancer (PC). A comprehensive literature search was conducted in the Medline, Web of Science, and Embase databases. The hazard ratio (HR) and corresponding 95% confidence interval (CI) for the association between myosteatosis and survival outcomes were pooled using a random-effects model. A total of 14 studies were included. The pooled analysis demonstrated that myosteatosis was significantly associated to poorer OS (HR: 1.50, 95% CI: 1.35–1.67, <em>p</em> < 0.001; <em>I</em><sup><em>2</em></sup> = 0%). The subgroup analysis revealed consistent results across various study characteristics, including geographic regions, cancer stages, follow-up durations, and study quality. In addition, myosteatosis was associated to worse PFS (HR: 1.34, 95% CI: 1.15–1.57, <em>p</em> < 0.001; <em>I</em><sup><em>2</em></sup> = 34%). The present meta-analysis indicates that myosteatosis is associated to significantly worse OS and PFS in patients with PC.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111343"},"PeriodicalIF":4.6,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0