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Anti-smudge superhard transparent coatings via ultra-small nanoparticle pattern surfaces

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.111996

Jieran Li , Xiubin Xu , Dian Lin , Yueyan Liang , Yashi Huang , Xu Wu

{"title":"Anti-smudge superhard transparent coatings via ultra-small nanoparticle pattern surfaces","authors":"Jieran Li , Xiubin Xu , Dian Lin , Yueyan Liang , Yashi Huang , Xu Wu","doi":"10.1016/j.isci.2025.111996","DOIUrl":"10.1016/j.isci.2025.111996","url":null,"abstract":"<div><div>Anti-smudge coating materials have a broad prospect, but they are susceptible to wear from nails and sand. Therefore, the potential application of such coatings on glass substrates needs coating features such as superhardness and high transparency. However, realizing these key properties combined with anti-smudge function is significantly challenging. In this work, we show a conceptional nanoparticle pattern designing strategy of materials, inspired by stepping on cobblestone roads with the foot feeling of only the hardness of stones. Realize the nanoparticle pattern surface of “cobblestone roads” via facile and scalable interfacial reactions within a molecular compatible system, to successfully achieve the desired coating material properties including anti-smudge, superhardness, and high transparency. The coating was composed of tensely crosslinked sub-10 nm building blocks that bear an anti-smudge molecular layer, exhibiting undistinguished inorganic phase behavior when it was subjected to external forces within the contact point of micro- or above 10 nm nanoscale.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111996"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143478661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal-coherence induces binding of responses to sound sequences in ferret auditory cortex

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.111991

Kai Lu , Kelsey Dutta , Ali Mohammed , Mounya Elhilali , Shihab Shamma

{"title":"Temporal-coherence induces binding of responses to sound sequences in ferret auditory cortex","authors":"Kai Lu , Kelsey Dutta , Ali Mohammed , Mounya Elhilali , Shihab Shamma","doi":"10.1016/j.isci.2025.111991","DOIUrl":"10.1016/j.isci.2025.111991","url":null,"abstract":"<div><div>Binding the attributes of a sensory source is necessary to perceive it as a unified entity within its surrounding scene as in the cocktail party problem in auditory perception. It is postulated that coherent temporal modulation of a source’s features binds them and enhances their perception. This study seeks evidence for rapid binding among coherently responsive single-neurons in ferret auditory cortex. In one experiment, ferrets attended to a sequence of noise bursts while we contrasted responses to simultaneous synchronized versus alternating tone sequences. We found that the contrast between synchronized (enhanced) and desynchronized (suppressed) responses rapidly increased, thus promoting their segregation. In another experiment, a sequence of an irregularly repeated multi-tone complex was embedded in a background of randomly dispersed tones. Single-unit and functional ultrasound imaging of responses to the temporally coherent tones of the complex became rapidly enhanced against the background responses, demonstrating the role of temporal-coherence in binding and segregation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111991"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.111999

Justine Oliva , Manon Ruffin , Claire Calmel , Aurélien Gibeaud , Andrés Pizzorno , Clémence Gaudin , Solenne Chardonnet , Viviane de Almeida Bastos , Manuel Rosa-Calatrava , Antoine Soulé , Amin Emad , Simon Rousseau , Harriet Corvol , Olivier Terrier , Loïc Guillot

{"title":"Divergent responses to SARS-CoV-2 infection in bronchial epithelium with pre-existing respiratory diseases","authors":"Justine Oliva , Manon Ruffin , Claire Calmel , Aurélien Gibeaud , Andrés Pizzorno , Clémence Gaudin , Solenne Chardonnet , Viviane de Almeida Bastos , Manuel Rosa-Calatrava , Antoine Soulé , Amin Emad , Simon Rousseau , Harriet Corvol , Olivier Terrier , Loïc Guillot","doi":"10.1016/j.isci.2025.111999","DOIUrl":"10.1016/j.isci.2025.111999","url":null,"abstract":"<div><div>Pre-existing respiratory diseases may influence coronavirus disease (COVID-19) susceptibility and severity. However, the molecular mechanisms underlying the airway epithelial response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection severity in patients with chronic respiratory diseases remain unelucidated. Using an <em>in vitro</em> model of differentiated primary bronchial epithelial cells, we aimed to investigate the molecular mechanisms of SARS-CoV-2 infection in pre-existing cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Our study revealed reduced susceptibility of CF and COPD airway epithelia to SARS-CoV-2, relative to that in healthy controls. Mechanistically, reduced transmembrane serine protease 2 (TMPRSS2) activity potentially contributed to this resistance of CF epithelium. Upregulated complement and inflammatory pathways in CF and COPD epithelia potentially primed the antiviral state prior to infection. Analysis of a COVID-19 patient cohort validated our findings, correlating specific inflammatory markers (IP-10, SERPINA1, and CFB) with COVID-19 severity. This study elucidates SARS-CoV-2 pathogenesis and identifies potential biomarkers for clinical monitoring.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111999"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.112010

Yifan Zhang , Masaki Nomura , Koutarou Nishimura , Weijia Zang , Yui Koike , Muran Xiao , Hiromi Ito , Miki Fukumoto , Atsushi Tanaka , Yumi Aoyama , Wataru Saika , Chihiro Hasegawa , Hiromi Yamazaki , Akifumi Takaori-Kondo , Daichi Inoue

{"title":"In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles","authors":"Yifan Zhang , Masaki Nomura , Koutarou Nishimura , Weijia Zang , Yui Koike , Muran Xiao , Hiromi Ito , Miki Fukumoto , Atsushi Tanaka , Yumi Aoyama , Wataru Saika , Chihiro Hasegawa , Hiromi Yamazaki , Akifumi Takaori-Kondo , Daichi Inoue","doi":"10.1016/j.isci.2025.112010","DOIUrl":"10.1016/j.isci.2025.112010","url":null,"abstract":"<div><div>The hierarchical organization of hematopoietic stem cells (HSCs) governing adult hematopoiesis has been extensively investigated. However, the dynamic epigenomic transition from fetal to adult hematopoiesis remains incompletely understood, particularly regarding the involvement of epigenetic factors. In this study, we investigate the roles of BRD9, an essential component of the non-canonical BAF (ncBAF) complex known to govern the fate of adult HSCs, in fetal hematopoiesis. Consistent with observations in adult hematopoiesis, BRD9 loss impairs fetal HSC stemness and disturbs erythroid maturation. Intriguingly, the impact on myeloid lineage was discrepant: BRD9 loss inhibited and promoted myeloid differentiation in fetal and adult models, respectively. Through comprehensive transcriptomic and epigenomic analysis, we elucidate the differential roles of BRD9 in a context- and lineage-dependent manner. Our data uncover how BRD9/ncBAF complex modulates transcription in a stage-specific manner, providing deeper insights into the epigenetic regulation underlying the transition from fetal to adult hematopoiesis.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 112010"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Astrocyte-induced firing in primary afferent axons

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.112006

Fanny Gaudel , Julia Giraud , Philippe Morquette , Marc Couillard-Larocque , Dorly Verdier , Arlette Kolta

{"title":"Astrocyte-induced firing in primary afferent axons","authors":"Fanny Gaudel , Julia Giraud , Philippe Morquette , Marc Couillard-Larocque , Dorly Verdier , Arlette Kolta","doi":"10.1016/j.isci.2025.112006","DOIUrl":"10.1016/j.isci.2025.112006","url":null,"abstract":"<div><div>The large-caliber primary afferents innervating the spindles of the jaw-closing muscles have their cell bodies located centrally in the mesencephalic trigeminal nucleus (NVmes). We have shown, in an acid-induced jaw muscle chronic myalgia model, that these afferents exhibit increased excitability and ectopic discharges that emerge from subthreshold membrane oscillations (SMOs) supported by a persistent sodium current (<em>I</em><sub>NaP</sub>) exquisitely sensitive to extracellular Ca<sup>2+</sup>-decreases. Here, we explore if the Ca<sup>2+</sup>-binding astrocytic protein, S100β, contributes to this hyperexcitability emergence and aim to localize the site where ectopic discharge arises using whole-cell patch-clamp recordings on mice brain slices. We found that astrocytes, by lowering [Ca<sup>2+</sup>]<sub>e</sub> at focal points along the axons of NVmes neurons through S100β, enhance the amplitude of the Na<sub>V</sub>1.6-dependent SMOs, leading to ectopic firing. These findings suggest a crucial role for astrocytes in excitability regulation and raise questions about this neuron-astrocyte interaction as a key contributor to hyperexcitability in several pathologies.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 112006"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precisely tuning the electronic states of organic polymer electrocatalysts via thiophene-based moieties for enhanced oxygen reduction reaction

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-12 DOI: 10.1016/j.isci.2025.112007

Dongye Li , Binbin Wang , Kunpeng Zheng , Hongni Chen , Yali Xing , Yanzhi Xia , Xiaojing Long

{"title":"Precisely tuning the electronic states of organic polymer electrocatalysts via thiophene-based moieties for enhanced oxygen reduction reaction","authors":"Dongye Li , Binbin Wang , Kunpeng Zheng , Hongni Chen , Yali Xing , Yanzhi Xia , Xiaojing Long","doi":"10.1016/j.isci.2025.112007","DOIUrl":"10.1016/j.isci.2025.112007","url":null,"abstract":"<div><div>Optimizing molecular structures in oxygen reduction reaction (ORR) is crucial for enhancing catalytic efficiency and stability, particularly with respect to the effective adsorption and conversion of reaction intermediates. Sulfur-containing heterocyclic compound thiophene can precisely modulate the electronic states and local charge densities, thereby fine-tuning the adsorption and reactivity of microporous polymers, yet, it remains a largely unexplored area. Herein, thiophene-based building blocks featuring diversified linkers into a phenyl-containing model Ph-CMP are developed, affording the thiophene-fused BPT-CMP and the thiophene-linked BCT-CMP. The electron density and adsorption capacity of the frameworks are well regulated through condensation and connecting modification, showing excellent half-wave potentials compared to the reversible hydrogen electrode, surpassing even most metal-free polymer electrocatalysts. Through theoretical calculations and experimental results, we have validated that the thiophene-fused skeleton (BPT-CMP) triggers the activation of thiophene units, with the exposed pentatomic heterocyclic carbon atom (site-3) serving as the catalytic active site.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 112007"},"PeriodicalIF":4.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143570550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ATP8A1-translocated endosomal phosphatidylserine fine-tunes the multivesicular body formation and the endo-lysosomal traffic

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-11 DOI: 10.1016/j.isci.2025.111973

Zengmei Lan , Yangli Tian , Chengang Li , Yudong Wang , Ping Yi , Rongying Zhang

{"title":"ATP8A1-translocated endosomal phosphatidylserine fine-tunes the multivesicular body formation and the endo-lysosomal traffic","authors":"Zengmei Lan , Yangli Tian , Chengang Li , Yudong Wang , Ping Yi , Rongying Zhang","doi":"10.1016/j.isci.2025.111973","DOIUrl":"10.1016/j.isci.2025.111973","url":null,"abstract":"<div><div>P4-ATPases are phospholipid flippases responsible for the transbilayer lipid asymmetry. ATP8A1, a P4-ATPase family member, has been reported to be involved in phosphatidylserine (PS) translocation at the <em>trans-</em>Golgi network, early endosomes and recycling endosomes. However, the possible roles of the PS on late endosomes/lysosomes pathway and how they are regulated remain to be elucidated. This study showed enrichment of ATP8A1 in Rab7-positive late endosomal compartments, and that ATP8A1 primarily flips the endosomal PS from the luminal leaflet to the cytosolic leaflet but not the PS in the inner leaflet of the plasma membrane. ATP8A1 depletion accelerates the lysosome-destined cargo proteins transfer into the intraluminal vesicles (ILVs) of multivesicular bodies (MVBs) and alters the signaling of epidermal growth factor receptor. Mechanistically, ATP8A1 depletion leads to PS loading in the luminal leaflet of MVB’s limiting membrane, which fine-tunes ILVs initiation and endosomal sorting complex required for transport (ESCRT) component recruitment.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111973"},"PeriodicalIF":4.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KAT6B overexpression in mice causes aggression, anxiety, and epilepsy

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-11 DOI: 10.1016/j.isci.2025.111953

Maria I. Bergamasco , Ezgi Ozturk , Pablo M. Casillas-Espinosa , Alexandra L. Garnham , Waruni Abeysekera , Verena C. Wimmer , Pradeep Rajasekhar , Hannah K. Vanyai , Lachlan Whitehead , Marnie E. Blewitt , Kelly Rogers , Adam P. Vogel , Anthony J. Hannan , Gordon K. Smyth , Nigel C. Jones , Tim Thomas , Anne K. Voss

{"title":"KAT6B overexpression in mice causes aggression, anxiety, and epilepsy","authors":"Maria I. Bergamasco , Ezgi Ozturk , Pablo M. Casillas-Espinosa , Alexandra L. Garnham , Waruni Abeysekera , Verena C. Wimmer , Pradeep Rajasekhar , Hannah K. Vanyai , Lachlan Whitehead , Marnie E. Blewitt , Kelly Rogers , Adam P. Vogel , Anthony J. Hannan , Gordon K. Smyth , Nigel C. Jones , Tim Thomas , Anne K. Voss","doi":"10.1016/j.isci.2025.111953","DOIUrl":"10.1016/j.isci.2025.111953","url":null,"abstract":"<div><div>Loss of the gene encoding the histone acetyltransferase KAT6B (MYST4/MORF/QKF) causes developmental brain abnormalities as well as behavioral and cognitive defects in mice. In humans, heterozygous variants in the <em>KAT6B</em> gene cause two cognitive disorders, Say-Barber-Biesecker-Young-Simpson syndrome (SBBYSS; OMIM:<span><span>603736</span><svg><path></path></svg></span>) and genitopatellar syndrome (GTPTS; OMIM:<span><span>606170</span><svg><path></path></svg></span>). Although the effects of <em>KAT6B</em> homozygous and heterozygous mutations have been documented in humans and mice, KAT6B gain-of-function effects have not been reported. Here, we show that overexpression of the <em>Kat6b</em> gene in mice caused aggression, anxiety, and spontaneous epilepsy. <em>Kat6b</em> overexpression led to an increase in histone H3 lysine 9 acetylation and upregulation of genes driving nervous system development and neuronal differentiation. <em>Kat6b</em> overexpression additionally promoted neural stem cell proliferation and favored neuronal over astrocyte differentiation <em>in vivo</em> and <em>in vitro</em>. Our results suggest that, in addition to loss-of-function alleles, gain-of-function <em>KAT6B</em> alleles may be detrimental for brain development.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111953"},"PeriodicalIF":4.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neural architecture of social punishment: Insights from a queue-jumping scenario

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-11 DOI: 10.1016/j.isci.2025.111988

Jiajia Zhu (朱佳佳) , Xiruo Zhang (张熙若) , Xiaotao Liu (刘晓涛) , Yan Mu (穆妍)

{"title":"Neural architecture of social punishment: Insights from a queue-jumping scenario","authors":"Jiajia Zhu (朱佳佳) , Xiruo Zhang (张熙若) , Xiaotao Liu (刘晓涛) , Yan Mu (穆妍)","doi":"10.1016/j.isci.2025.111988","DOIUrl":"10.1016/j.isci.2025.111988","url":null,"abstract":"<div><div>Punishment in social settings is crucial for maintaining collective interests, yet the underlying mechanisms remain unclear. To address this, we developed a paradigm, the queue-jumping task, where participants imagine experiencing a queue-jumping event through vivid pictorial scenarios. Behavioral findings revealed that individuals prioritized collective interests over personal ones when punishing, highlighting the altruistic nature of social punishment. Neuroimaging results demonstrated that social punishment activated multiple neural circuits associated with social norms (e.g., fusiform gyrus and posterior cingulate cortex), self-related processing (e.g., ventromedial prefrontal cortex and middle cingulate cortex), and punishment implementation (e.g., anterior dorsolateral prefrontal cortex and middle temporal gyrus). Brain network analyses uncovered a social punishment network whose efficacy in information transmission forecasts individuals’ tendency to punish. This study provides valuable insights into the cognitive and neural mechanisms involved in social punishment. The current paradigm closely reflects real-life queue-jumping situations and daily punitive behaviors, demonstrating its generalizability and validity.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"28 3","pages":"Article 111988"},"PeriodicalIF":4.6,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143474148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inspired by struggle: A personal journey to global precision brain health

IF 4.6 2区综合性期刊

iScience Pub Date : 2025-02-11 DOI: 10.1016/j.isci.2025.111918

Agustin Ibanez

引用次数: 0