iScience最新文献_第3页

AMPD3 promotes doxorubicin-induced cardiomyopathy through HSP90α-mediated ferroptosis AMPD3通过HSP90α介导的铁氧化促进多柔比星诱发的心肌病

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-13 DOI: 10.1016/j.isci.2024.111304

Liting Cheng, Mingxiang Zhu, Xiang Xu, Xin Li, Yongming Yao, Chunlei Liu, Kunlun He

引用次数: 0

Media frame development of direct air capture 2011–2023: A comparative analysis of Europe and North America 2011-2023 年直接空气捕获的媒体框架发展：欧洲和北美的比较分析

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-12 DOI: 10.1016/j.isci.2024.111360

Paul J. Upham , Emina Ibrahimović

引用次数: 0

Bio-inspiration unveiled: Dissecting nature’s designs through the lens of the female locust’s oviposition mechanism 揭开生物灵感的面纱：从雌蝗虫的产卵机制看大自然的设计

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-12 DOI: 10.1016/j.isci.2024.111378

Amir Ayali , Shai Sonnenreich , Bat El Pinchasik

{"title":"Bio-inspiration unveiled: Dissecting nature’s designs through the lens of the female locust’s oviposition mechanism","authors":"Amir Ayali , Shai Sonnenreich , Bat El Pinchasik","doi":"10.1016/j.isci.2024.111378","DOIUrl":"10.1016/j.isci.2024.111378","url":null,"abstract":"<div><div>Investigating nature’s ingenious designs and systems has become a cornerstone of innovation, influencing fields from robotics, biomechanics, and physics to material sciences. Two key questions, however, regarding bio-inspired innovation are those of how and where does one find bio-inspiration? The perspective presented here is aimed at providing insights into the evolving landscape of bio-inspiration discovery. We present the unique case of the female locust’s oviposition as a valuable example for researchers and engineers seeking to pursue multifaceted research, encompassing diverse aspects of biological and bio-inspired systems. The female locust lays her eggs underground to protect them and provide them with optimal conditions for survival and hatching. To this end, she uses a dedicated apparatus comprising two pairs of special digging valves to propagate underground, while remarkably extending her abdomen by 2- to 3-fold its original length. The unique digging mechanism, the subterranean steering ability, and the extreme elongation of the abdomen, including the reversible extension of the abdominal central nervous system, all spark a variety of questions regarding materials, morphology, mechanisms, and their interactions in this complex biological system. We present the cross-discipline efforts to elucidate these fascinating questions, and provide future directions for developing bio-inspired technological innovations based on this remarkable biological system.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111378"},"PeriodicalIF":4.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbapenem-resistant Acinetobacter baumannii raises global alarm for new antibiotic regimens 耐碳青霉烯类鲍曼不动杆菌引起全球对新抗生素方案的警惕

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-12 DOI: 10.1016/j.isci.2024.111367

Aswin Thacharodi , Avadh Vithlani , Saqib Hassan , Ali Alqahtani , Arivalagan Pugazhendhi

引用次数: 0

The role of deep learning in myocardial perfusion imaging for diagnosis and prognosis: A systematic review 深度学习在心肌灌注成像诊断和预后中的作用：系统综述

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-12 DOI: 10.1016/j.isci.2024.111374

Xueping Hu , Han Zhang , Federico Caobelli , Yan Huang , Yuchen Li , Jiajia Zhang , Kuangyu Shi , Fei Yu

{"title":"The role of deep learning in myocardial perfusion imaging for diagnosis and prognosis: A systematic review","authors":"Xueping Hu , Han Zhang , Federico Caobelli , Yan Huang , Yuchen Li , Jiajia Zhang , Kuangyu Shi , Fei Yu","doi":"10.1016/j.isci.2024.111374","DOIUrl":"10.1016/j.isci.2024.111374","url":null,"abstract":"<div><div>The development of state-of-the-art algorithms for computer visualization has led to a growing interest in applying deep learning (DL) techniques to the field of medical imaging. DL-based algorithms have been extensively utilized in various aspects of cardiovascular imaging, and one notable area of focus is single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI), which is regarded as the gold standard for non-invasive diagnosis of myocardial ischemia. However, due to the complex decision-making process of DL based on convolutional neural networks (CNNs), the explainability of DL results has become a significant area of research, particularly in the field of medical imaging. To better harness the potential of DL and to be well prepared for the ongoing DL revolution in nuclear imaging, this review aims to summarize the recent applications of DL in MPI, with a specific emphasis on the methods in explainable DL for the diagnosis and prognosis of MPI. Furthermore, the challenges and potential directions for future research are also discussed.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111374"},"PeriodicalIF":4.6,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating potential power output of terrestrial thermoradiative diodes with atmospheric modeling 利用大气建模评估地面热辐射二极管的潜在功率输出

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-09 DOI: 10.1016/j.isci.2024.111346

Jamie A. Harrison , Phoebe M. Pearce , Fei Yang , Michael P. Nielsen , Helen E. Brindley , Nicholas J. Ekins-Daukes

引用次数: 0

Immunogenic peptides putatively from intratumor microbes: Opportunities for colorectal cancer treatment 可能来自肿瘤内微生物的免疫原肽：结直肠癌治疗的机遇

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-09 DOI: 10.1016/j.isci.2024.111338

Xiangyu Guan , Fanyu Bu , Yunyun Fu , Haibo Zhang , Haitao Xiang , Xinle Chen , Tai Chen , Xiaojian Wu , Kui Wu , Longqi Liu , Xuan Dong

{"title":"Immunogenic peptides putatively from intratumor microbes: Opportunities for colorectal cancer treatment","authors":"Xiangyu Guan , Fanyu Bu , Yunyun Fu , Haibo Zhang , Haitao Xiang , Xinle Chen , Tai Chen , Xiaojian Wu , Kui Wu , Longqi Liu , Xuan Dong","doi":"10.1016/j.isci.2024.111338","DOIUrl":"10.1016/j.isci.2024.111338","url":null,"abstract":"<div><div>Recent evidence has confirmed the presence of intratumor microbes, yet their impact on the immunopeptidome remains largely unexplored. Here we introduced an integrated strategy to identify the immunopeptidome originated from intratumor microbes. Analyzing 10 colorectal cancer (CRC) patients, we identified 154 putative microbe-derived human leukocyte antigen (HLA)-I ligands. Predominantly bacterial in origin, these peptides were notably abundant in <em>Fusobacterium nucleatum</em>, the most prevalent bacterium differentiating between normal and tumor tissues. We discovered 20 peptides originating from <em>F</em>. <em>nucleatum</em>, thirteen of which, including two peptides shared across multiple patients, were tumor specific. Validation experiments confirmed that the putative microbe-derived peptide could activate CD8<sup>+</sup> T cell responses. Our findings indicate that HLA-I molecules are capable of presenting intratumor microbe-derived peptides in CRC, potentially contributing to CD8<sup>+</sup> T cell-mediated immunity and suggesting potential strategies for cancer immunotherapy.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111338"},"PeriodicalIF":4.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway HucMSCs 可通过 MAPK 信号通路缓解高糖诱导的异常血管生成

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-09 DOI: 10.1016/j.isci.2024.111354

Yang Yao , Tiantian Shan , Xiaoying Li

{"title":"HucMSCs can alleviate abnormal vasculogenesis induced by high glucose through the MAPK signaling pathway","authors":"Yang Yao , Tiantian Shan , Xiaoying Li","doi":"10.1016/j.isci.2024.111354","DOIUrl":"10.1016/j.isci.2024.111354","url":null,"abstract":"<div><div>Vascular complications caused by diabetes mellitus contribute a major threat to increased disability and mortality of diabetic patients, which are characterized by damaged endothelial cells and angiogenesis. Human umbilical cord-derived mesenchymal stem cells (hucMSCs) have been demonstrated to alleviate endothelial cell damage and improve angiogenesis. However, these investigations overlooked the pivotal role of vasculogenesis. In this study, we utilized blood vessel organoids (BVOs) to investigate the impact of high glucose on vasculogenesis and subsequent angiogenesis. We found that BVOs in the vascular lineage induction stage were more sensitive to high glucose and more susceptible to affect endothelial cell differentiation and function. Moreover, hucMSCs can alleviate the high glucose-induced inhibition of endothelial cell differentiation and dysfunction through MAPK signaling pathway downregulation, with the MAPK activator dimethyl fumarate further illustrating the results. Thereby, we demonstrated that high glucose can lead to abnormal vasculogenesis and impact subsequent angiogenesis, and hucMSCs can alleviate this effect.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111354"},"PeriodicalIF":4.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice 脂肪细胞 Angptl8 基因缺失可改善小鼠的葡萄糖和能量代谢以及与肥胖相关的炎症反应

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-09 DOI: 10.1016/j.isci.2024.111292

Anindya Ghosh , Isabelle Chénier , Yat Hei Leung , Abel K. Oppong , Marie-Line Peyot , S. R. Murthy Madiraju , Irina Al-Khairi , Jehad Abubaker , Fahd Al-Mulla , Marc Prentki , Mohamed Abu-Farha

{"title":"Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice","authors":"Anindya Ghosh , Isabelle Chénier , Yat Hei Leung , Abel K. Oppong , Marie-Line Peyot , S. R. Murthy Madiraju , Irina Al-Khairi , Jehad Abubaker , Fahd Al-Mulla , Marc Prentki , Mohamed Abu-Farha","doi":"10.1016/j.isci.2024.111292","DOIUrl":"10.1016/j.isci.2024.111292","url":null,"abstract":"<div><div>Angiopoietin-like protein 8 (Angptl8), expressed in the liver and adipocytes, forms a complex with Angptl3 or Angptl4, which regulates lipoprotein lipase and triglyceride metabolism. However, the precise functions of adipocyte Angptl8 remain elusive. Here we report that adipocyte-specific inducible Angptl8-knockout (AT-A8-KO) male mice on normal diet showed minor phenotypic changes, but after a high-fat high fructose (HFHF) diet, exhibited decreased body weight gain and glycemia, elevated rectal temperature and early dark phase energy expenditure compared to the Cre controls. AT-A8-KO mice also displayed improved glucose tolerance, a trend for better insulin sensitivity, improved insulin-stimulated glucose uptake in adipose tissues, and reduced visceral adipose tissue crown-like structures, plasma MCP-1 and leptin levels. The results indicate the importance of adipose Angptl8 in the context of nutri-stress and obesity, as its deletion in mice promotes a metabolically healthy obese phenotype by slightly ameliorating obesity, improving glucose and energy homeostasis, and mitigating inflammation.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111292"},"PeriodicalIF":4.6,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-lowering drug and complement factor H genotyping–personalized treatment strategy for age-related macular degeneration 降脂药物和补体因子 H 基因分型--老年性黄斑变性的个性化治疗策略

IF 4.6 2区综合性期刊

iScience Pub Date : 2024-11-08 DOI: 10.1016/j.isci.2024.111344

Can Can Xue , Kelvin Y.C. Teo , Yih Chung Tham , Hengtong Li , Sahil Thakur , Charumathi Sabanayagam , Qiao Fan , David L. Silver , Xiaomeng Wang , Chui Ming Gemmy Cheung , Tien Yin Wong , Usha Chakravarthy , Ching-Yu Cheng , Simon Nusinovici

{"title":"Lipid-lowering drug and complement factor H genotyping–personalized treatment strategy for age-related macular degeneration","authors":"Can Can Xue , Kelvin Y.C. Teo , Yih Chung Tham , Hengtong Li , Sahil Thakur , Charumathi Sabanayagam , Qiao Fan , David L. Silver , Xiaomeng Wang , Chui Ming Gemmy Cheung , Tien Yin Wong , Usha Chakravarthy , Ching-Yu Cheng , Simon Nusinovici","doi":"10.1016/j.isci.2024.111344","DOIUrl":"10.1016/j.isci.2024.111344","url":null,"abstract":"<div><div>We investigated whether the effect of lipid-lowering drugs (LLDs) on age-related macular degeneration (AMD) differs according to the main complement genetic variants in Singapore Epidemiology of Eye Diseases (SEED) (<em>n</em> = 5,579) and UK Biobank studies (<em>n</em> = 445,727). The effect of LLD was determined for each stratum of 20 complement genetic variants. In SEED, 484 individuals developed AMD and 216 showed progression over 6 years. In the UK Biobank, 913 participants developed AMD over 11 years. rs1061170 variant (complement factor H gene) was the only variant for which we found a protective effect in both populations. This effect was found in individuals carrying at least one C allele in SEED (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.19–0.87) and in individuals carrying two C alleles in UK Biobank (hazard ratio [HR] = 0.65; 95% CI, 0.45–0.93). These effects corresponded to a 50% and 35% decrease in AMD risk, respectively. Our study highlights the potential for personalized therapy for AMD based on complement genotyping.</div></div>","PeriodicalId":342,"journal":{"name":"iScience","volume":"27 12","pages":"Article 111344"},"PeriodicalIF":4.6,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0