Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-09-04 DOI:10.1016/j.isci.2025.113502

Mao Hagihara , Makoto Yamashita , Tadashi Ariyoshi , Ayaka Minemura , Chika Yoshida , Seiya Higashi , Kentaro Oka , Motomichi Takahashi , Akinobu Ota , Akihiro Maenaka , Kenta Iwasaki , Jun Hirai , Yuichi Shibata , Takumi Umemura , Takeshi Mori , Hideo Kato , Nobuhiro Asai , Hiroshige Mikamo

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引用次数: 0

Abstract

We previously reported that orally administered Clostridium butyricum enhances anti-influenza virus effects through the interferon-λ upregulation in mice lungs; however, the precise mechanism remains unclear. Orally administered C. butyricum promotes the proliferation of Bifidobacterium species in the lung microbiome, and this enhances C. butyricum induced anti-influenza effects. Among the Bifidobacterium species, B. longum effectively enhanced the sensitivity of the lung epithelial cells to long-chain fatty acids through the G-protein-coupled receptor120 upregulation. Oral administration of C. butyricum altered long-chain fatty acid metabolism and promoted interferon-λ production through G-protein-coupled receptor120. We hypothesized that these effects enhance anti-influenza virus responses through interferon-λ upregulation via collaboration between long-chain fatty acid metabolism alterations and the lung microbiome moderation. This study identified a gut-lung axis mechanism and provides insights into viral respiratory infection treatment and prophylaxis.

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丁酸梭菌改变的肺微生物组通过g蛋白偶联受体与增强抗流感作用相关120

我们之前报道过口服丁酸梭菌通过上调小鼠肺部干扰素-λ增强抗流感病毒作用；然而，确切的机制尚不清楚。口服丁酸梭菌可促进肺微生物群中双歧杆菌的增殖，从而增强丁酸梭菌诱导的抗流感作用。在双歧杆菌中，长芽胞杆菌通过g蛋白偶联受体120的上调，有效增强了肺上皮细胞对长链脂肪酸的敏感性。口服丁酸梭菌可改变长链脂肪酸代谢，并通过g蛋白偶联受体促进干扰素λ的产生120。我们假设这些效应通过长链脂肪酸代谢改变和肺微生物组调节之间的协作，通过干扰素-λ上调来增强抗流感病毒反应。本研究确定了肠-肺轴机制，并为病毒性呼吸道感染的治疗和预防提供了见解。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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