Journal of Radiation Research and Applied Sciences最新文献

{"title":"Oestrogen inhibition of apoptosis causes upregulation of KLF5 and poor prognosis in female non-small cell lung cancer patients","authors":"Hua Liao ,&nbsp;Jiaxin Lin ,&nbsp;Miao Zhang ,&nbsp;Xingdong Cai ,&nbsp;Guangshu Chen ,&nbsp;Zewei Jiang ,&nbsp;Li Che ,&nbsp;Shengming Liu","doi":"10.1016/j.jrras.2025.101655","DOIUrl":"10.1016/j.jrras.2025.101655","url":null,"abstract":"<div><h3>Background</h3><div>KLF5 is closely related to tumour growth, proliferation, and blood vessel formation. Our study was designed to explore the role of KLF5 in non-small cell lung cancer (NSCLC) and its impact on clinical prognosis.</div></div><div><h3>Methods</h3><div>Lung tissue specimens of patients diagnosed with NSCLC were collected, and KLF5 protein expression was detected in tissues. We then compared KLF5 expression levels in NSCLC patients of different sexes and its impact on clinical features using samples from the TCGA and GEPIA databases, and performed GO and KEGG enrichment analyses on KLF5, ESR1 and related genes. Finally, in vitro experiments using NSCLC PC-9 cells demonstrated estradiol mediated regulation of KLF5 expression and apoptosis were demonstrated at the cellular level.</div></div><div><h3>Results</h3><div>KLF5 mRNA was 2.5-fold higher in NSCLC tissues vs. adjacent tissues (p = 0.003), and protein levels increased by 1.8-fold (p = 0.01), which indicated that KLF5 was significantly over-expressed in cancerous tissues of NSCLC patients. This consistent over-expression pattern was clinically consequential, as survival analysis revealed the poor prognosis of patients was related to the over-expression of KLF5. Further analysis showed that KLF5 expression was lower in female patients than in male patients. Multivariate regression analysis showed that high KLF5 expression (HR = 1.328, p &lt; 0.05) was an independent risk factor for lung cancer prognosis, but only in female patients. Oestrogen and oestrogen receptor inhibitors were shown to mediate KLF5 protein expression at the cellular level. In addition, with increasing concentrations of oestrogen, the expression of Bcl2 was progressively increased, the expression of Bax was progressively down-regulated, and the apoptosis of NSCLC cells decreases, and that this effect was dependent on the regulation of KLF5.</div></div><div><h3>Conclusion</h3><div>Estrogen upregulates KLF5, which suppresses pro-apoptotic Bax and enhances anti-apoptotic Bcl-2, reducing caspase-3 activation KLF5 may represent a potential therapeutic target for female NSCLC, warranting further preclinical and clinical investigation These findings are primarily derived from in vitro models; future in vivo studies are needed to confirm clinical relevance.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101655"},"PeriodicalIF":1.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a cancer-associated fibroblast-related lncRNA signature for forecasting the prognosis, immune infiltration and drug response of breast cancer","authors":"Kefang Chen ,&nbsp;Xiaojin Xue ,&nbsp;Weimin Yi,&nbsp;Liang Ai,&nbsp;Changzhi Yu,&nbsp;Jianjun Li,&nbsp;Qihui Huang,&nbsp;Linhui Cao","doi":"10.1016/j.jrras.2025.101685","DOIUrl":"10.1016/j.jrras.2025.101685","url":null,"abstract":"<div><h3>Objective</h3><div>Cancer-associated fibroblasts (CAFs)-associated long-non coding RNAs (lncRNAs) are key players in cancer progression. This study intended to develop a CAF-related lncRNA signature to forecast breast cancer prognosis, immune infiltration and drug response.</div></div><div><h3>Methods</h3><div>The breast cancer-related public data were downloaded. Key CAF-related lncRNAs were screened for establishing the CAF-related lncRNA prognostic signature. The clinical utility of this signature was evaluated, and a nomogram was established by combining prognostic signature with clinical factors. Furthermore, immune cell infiltration analysis, drug sensitivity analysis, and Gene Set Enrichment Analysis (GSEA) of different risk groups were conducted. Besides, the expression of signature lncRNAs was validated in five breast cancer cell lines utilizing quantitative PCR (qPCR).</div></div><div><h3>Results</h3><div>CAF levels were increased in breast cancer samples and samples with high CAF levels had poor prognosis. A prognostic signature was built by eight CAF-related prognostic lncRNAs, including LINC00844, SENCR, NR2F2-AS1, HAND2-AS1, MIR31HG, CACNA1G-AS1, LINC01120, and LINC00626, which had a high prognostic performance, with AUC value of 0.844 (0.949, 0.705) and 0.742 (0.828, 0.614) in training and validation datasets, respectively. Then, a prognostic nomogram was established, which had high survival prediction accuracy and clinically useful. The prognostic signature was related to immune cell infiltration, particularly CD8⁺ T cell and M2 macrophage, response to several drugs like AZD7762 and cisplatin, and differential pathways, including cell cycle. Besides, qPCR confirmed the reduced expression of LINC00844, SENCR, NR2F2-AS1, HAND2-AS1, MIR31HG, and CACNA1G-AS1 and elevated expression of LINC01120 and LINC00626 in breast cancer cells.</div></div><div><h3>Conclusions</h3><div>A robust CAF-related lncRNA signature was developed, offering valuable insights into forecasting prognosis and optimizing therapeutic strategies for breast cancer.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101685"},"PeriodicalIF":1.7,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144271144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Slip and thermal effects on MHD fractional Jeffrey nanofluid flow","authors":"Shajar Abbas ,&nbsp;S. Saleem ,&nbsp;Maryam Fatima ,&nbsp;Ioan-Lucian Popa ,&nbsp;Mudassar Nazar ,&nbsp;Ghada Ragheb Elnaggar ,&nbsp;Rashid Jan","doi":"10.1016/j.jrras.2025.101688","DOIUrl":"10.1016/j.jrras.2025.101688","url":null,"abstract":"<div><div>Nanofluids with superior thermal characteristics are increasingly important in radiation-influenced environments across industrial and biomedical domains. This work develops a fractional-order model describing the mixed convection flow of human blood-based nanofluids embedded with single-wall carbon nanotubes (SWCNTs) and multi-wall carbon nanotubes (MWCNTs) along an infinite vertical surface. To capture memory and hereditary effects, the constant proportional Caputo (CPC) operator is utilized, while the Laplace technique yields semi-analytical solutions for temperature, velocity, and concentration profiles, and its inverse Laplace transform is obtained using the Stehfest and Tzou algorithm. The results show that thermal radiation significantly enhances heat transfer, with a 12 % increase in temperature for blood-SWCNT nanofluid due to superior thermal conductivity, while blood-MWCNT nanofluid exhibits higher velocity due to lower density. These findings contribute to the development and optimization of nanofluid systems for use in industrial engineering applications, including high-performance heat exchangers, solar collectors, electronic cooling systems, and biomedical thermal therapies where precise thermal diffusion control over is essential.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101688"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat transfer and irreversibility analysis in porous vertical disk configuration with Navier slip, thermal jump and quadratic Radiation: Numerical study using Corcione's correlation","authors":"Khadija Rafique ,&nbsp;Zafar Mahmood ,&nbsp;Hamiden Abd El-Wahed Khalifa ,&nbsp;Emad A.A. Ismail ,&nbsp;Fuad A. Awwad ,&nbsp;Abhinav Kumar ,&nbsp;Seham Sh Tantawy","doi":"10.1016/j.jrras.2025.101678","DOIUrl":"10.1016/j.jrras.2025.101678","url":null,"abstract":"<div><div>This study presents the Corcione correlation, emphasizing the effects of fluid temperature, particle volume fraction, and particle size on the improvement of nanofluid heat transfer rate. This study examines the stagnation point flow of a nanofluid consisting of <span><math><mrow><msub><mrow><mi>A</mi><mi>l</mi></mrow><mn>2</mn></msub><msub><mi>O</mi><mn>3</mn></msub><mo>/</mo><msub><mi>H</mi><mn>2</mn></msub><mi>O</mi></mrow></math></span> across a vertically extending or shrinking disk. The study is conducted for nanoparticle sizes of <span><math><mrow><mn>28</mn><mo>,</mo><mn>30</mn><mtext>,</mtext></mrow></math></span> and <span><math><mrow><mn>45</mn></mrow></math></span> nm, with volume concentrations reaching up to 4 %. The Navier velocity slip and thermal slip conditions enhance the mathematical model. It also looks at the effects of magnetohydrodynamics, suction, porous media, Joule heating, quadratic thermal radiation, viscous dissipation, and the production of entropy. The bvp4c solver numerically solves the system of ordinary differential equations created by the similarity transformation of the partial differential equations. For both the stretching and shrinking scenarios, graphs and tables illustrate the effects of several relevant factors. In the event of stretching, the velocity profile exhibits a declining trend for the Navier slip parameter, porosity, magnetic field, and mass suction parameters; in the case of shrinking, however, the opposite behavior is seen. The temperature profile increases with the nanoparticle volume fraction, radiation, and temperature ratio factors in both scenarios. Both cases show an increase in entropy production for the brinkman number and a reduction in entropy generation for the temperature difference. Skin friction and Nusselt number are measured for dp = 28, 30, and 45 nm nanoparticle sizes. The Nusselt number is larger for dp = 45 nm than 28 nm and 30 nm, while skin friction is higher for 28 nm. There exists an almost perfect concordance (with a relative error of around 0 %) between the present and previous results.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101678"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing a simulator for Generalized multi-hit multi-target (GMHMT) radiobiological model in cancer treatment through ionizing radiation therapy","authors":"Aryaveer Singh ,&nbsp;Rajiv Kumar Singh ,&nbsp;Fidele Maniraguha","doi":"10.1016/j.jrras.2025.101680","DOIUrl":"10.1016/j.jrras.2025.101680","url":null,"abstract":"<div><div>Radiation therapy plays a critical role in cancer treatment, necessitating accurate radiobiological models for predicting tumor cell survival. Traditional models such as the Linear-Quadratic (LQ) and Lea's target models are often inadequate in high-dose scenarios. To address this limitation, we present a MATLAB-based simulation tool implementing the Generalized Multi-Hit Multi-Target (GMHMT) model, which incorporates multi-hit and multi-target dynamics along with a negation parameter to account for repair mechanisms and non-targeted effects. This tool allows users to input tumor-specific parameters—including cell volume, number of targets and hits, and the negation factor—to simulate survival fractions under varying doses. Simulation results demonstrate strong alignment with published experimental data, achieving an RMSE of 0.1030 and an R² value of 0.9128. Sensitivity analysis reveals that dose and tumor volume are primary influencers of survival fraction, underscoring the model's relevance for personalized treatment planning. The GMHMT simulator offers improved accuracy over classical models and provides a user-friendly interface for both clinical and research applications in radiobiological modeling and therapy optimization.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101680"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Step edge and edge loss enhanced Transformer for medical image segmentation","authors":"Juan Zheng ,&nbsp;Mei Tian ,&nbsp;Meng Zhou ,&nbsp;Jing Cai ,&nbsp;Chanzi Liu ,&nbsp;Tao Lin ,&nbsp;Haibo Si","doi":"10.1016/j.jrras.2025.101667","DOIUrl":"10.1016/j.jrras.2025.101667","url":null,"abstract":"<div><h3>Objective</h3><div>Knee osteoarthritis (KOA) is the most common degenerative joint disease, significantly impacting patients' quality of life. Currently, KOA assessments using ultrasound images rely on complex, time-consuming manual measurements. Developing automatic, accurate medical image segmentation methods for clinical diagnosis is crucial. However, due to challenges like blurred boundaries and irregular shapes in medical images, existing methods show poor edge accuracy and morphological differences.</div></div><div><h3>Methods</h3><div>To address these issues, we propose IELSEMT model. The model proposes a step edge module, incorporating it into both global and local branches during training. Additionally, after integrating the step edge module, the network's edge feature extraction capability is enhanced. During the network's backpropagation phase, we propose a weighted loss function that incorporates edge loss terms, specifically using the weighted sum of cross-entropy and mean absolute error as the network's loss function, reducing edge region errors in network segmentation results.</div></div><div><h3>Results</h3><div>Compared to the convolutional baseline, the IELSEMT model improves F1_Score by approximately 5 % and IoU by 15 %. Compared to the Med baseline model, IoU and F1 Score are about 4 % higher. Additionally, by incorporating edge loss terms during the backpropagation phase, the network training speed is enhanced. The IELSEMT model can quickly locate segmentation object edges and trains faster, achieving a convergence speed twice that of the MedT model.</div></div><div><h3>Conclusion</h3><div>The IELSEMT model proposed in this paper incorporates full-scale and edge detection concepts, introducing edge information into the decoding phase to achieve more accurate edge information acquisition, improving segmentation accuracy with clearer and more precise edges. Unlike other Transformer-based models, our proposed method does not require pre-training on large-scale datasets. Finally, we conducted experiments on knee joint ultrasound datasets, where IELSEMT demonstrated superior performance over both CNN and other related Transformer-based architectures.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101667"},"PeriodicalIF":1.7,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of effect of pitch change on radiation dose in head and abdominal computed tomography scans: A phantom study","authors":"Güneş Açıkgöz,&nbsp;Hatice Erdem","doi":"10.1016/j.jrras.2025.101691","DOIUrl":"10.1016/j.jrras.2025.101691","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of the study was to examine the pitch value, which is one of the parameters affecting the radiation dose. In both adult and pediatric head and abdominal Computed Tomography (CT) examination protocols, CTDIvol and DLP values were obtained at different pitch values using a phantom.</div></div><div><h3>Methods</h3><div>The pitch values determined automatically by the CT device for adult head, child head, adult abdomen and child abdomen scans were recorded as 0.35, 0.6, 1.25 and 1.20, respectively. Then, scans were taken at pitch values of 0.6, 0.8, 1.0, 1.2, and 1.5 for adult head and abdomen. Statistical analyses were performed using OriginPro and SPSS statistical programs.</div></div><div><h3>Results</h3><div>According to the PCA (Principal Component Analysis) method, PC1 (Principal Component) was obtained as 58.93 %, PC2 (Principal Component) as 29.41 %, and the sum of both PCs was observed to constitute 88.34 % of the total variance. In the K-Means cluster analysis, two different classes were obtained. According to the CTDIvol and DLP measurements, it was observed that the measurement with the highest PC1 score was the adult abdominal CT scan with a pitch value of 1.5.</div></div><div><h3>Conclusion</h3><div>According to the results obtained, it can be said that changing the pitch value affects the CTDIvol and DLP values, which are radiation dose indicators and found on the dose page. In addition, it can be said that it would be advantageous to use PCA and k-means cluster analysis, which are Unsupervised Machine Learning methods, on data obtained from computer-aided imaging devices such as CT.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101691"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial circ_0010074 induces cardiac inflammation to facilitate fibrosis by upregulating NLRP1 via sponging miR-214–3p with m6A modification after myocardial infarction","authors":"Yunhua Liu ,&nbsp;Xiaoyu Li ,&nbsp;Yahan Yu ,&nbsp;Wenjuan Wang ,&nbsp;Anqi Li ,&nbsp;Yunliang Yao","doi":"10.1016/j.jrras.2025.101673","DOIUrl":"10.1016/j.jrras.2025.101673","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Myocardial infarction (MI) is a life-threatening coronary artery disease, and the in-hospital mortality rate of MI is up to 14.7 %. It is urgent to explore novel therapeutic targets and strategies for MI. Though circular RNAs (circRNAs) play fundamental roles in MI, the knowledge about circRNAs in MI is limited, and the effect of myocardial circ_0010074 on MI remains unknown.</div></div><div><h3>Methods</h3><div>In this study, primary murine cardiomyocytes and cardiac fibroblasts were utilized, and primary cardiomyocytes were exposed to H₂O₂ for establishing MI model <em>in vitro</em>. Besides, the regulatory effects among circRNA-microRNA (miRNA)-mRNA were identified by dual-luciferase reporter gene assay, and N⁶-methyladenosine (m⁶A) modification of circ_0010074 was detected by methylated RNA Immunoprecipitation (MeRIP).</div></div><div><h3>Results</h3><div>The investigation indicates that myocardial circ_0010074 is upregulated after MI. Moreover, myocardial circ_0010074 induces NOD-like receptor family pyrin domain-containing 1 (NLRP1) inflammation and NLRP1-mediated cardiac fibrosis after MI. Mechanistically, myocardial circ_0010074 elevates NLRP1 expressing by sponging miR-214–3p. Besides, m⁶A modification enhances circ_0010074 to sponge miR-214–3p in cardiomyocytes after MI.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that myocardial circ_0010074 triggers cardiac inflammation to facilitate fibrosis by increasing NLRP1 expression via sponging miR-214–3p depended on m⁶A modification after MI, which might provide novel therapeutic targets to dig more effective drugs for treating MI.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101673"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon attenuation, dose rate and buildup factors of porous glasses containing GeO2","authors":"M.S. Al-Buriahi ,&nbsp;S.S. Owoeye ,&nbsp;Hind Saeed Alzahrani ,&nbsp;Norah Salem Alsaiari ,&nbsp;Imed Boukhris ,&nbsp;Elif Kemah","doi":"10.1016/j.jrras.2025.101659","DOIUrl":"10.1016/j.jrras.2025.101659","url":null,"abstract":"<div><div>In this present work, SiO₂–GeO₂–Na₂O–B₂O₃ (SiGeNaBx) glass compositions containing varying additions of GeO₂ (22, 33, 44, and 55 mol. %) coded as SiGeNaB1, SiGeNaB2, SiGeNaB3, and SiGeNaB4, respectively, were reported. The effects of variation of GeO₂ on the radiation protective properties of the developed porous glasses were then analyzed. The elemental composition showed the glasses contain elements of B (boron), O (oxygen), Si (silicon), germanium (Ge), and Na (sodium), with an increased weight percent of Ge, establishing the formulated glasses. Both mass attenuation coefficient (MAC) and mass energy-absorption coefficient (MEAC) increased with increased GeO₂ content, respectively, with SiGeNaB4 exhibiting higher MAC and MEAC values of 42.61 and 29.32 cm²g^-1, respectively, but with increased radiation intensity (<span><math><mrow><mi>Γ</mi></mrow></math></span>) lower energies. Both effective atomic number (Z_eff) and electron density (N_eff) also increased with increased GeO₂ additions at lower energies (0.015–0.1 MeV). The gamma dose rate decreased with increased thickness of glass samples for all the compositions, while SiGeNaB4 exhibited a lower dose rate, suggesting better shielding performance. Sample SiGeNaB4 also displayed a lower exposure build factor (EBF) at lower energy levels. However, in comparison to other radiation shielding glasses, the developed glasses exhibited promising properties, establishing their potential as radiation shielding materials at low photon energy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101659"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Al18F-NOTA-FAPI-04 PET/CT imaging for visualization and localization of ovarian and peritoneal endometriotic lesions in a rat model","authors":"Lijun Yin ,&nbsp;Qianhe Xu ,&nbsp;Ahmad Alhaskawi ,&nbsp;Yongyi Yang ,&nbsp;Jie Shi ,&nbsp;Xinhui Zhou ,&nbsp;Shi Feng ,&nbsp;Yinying Zou ,&nbsp;Guoliang Xie ,&nbsp;Weihua He ,&nbsp;Xinhui Su ,&nbsp;Zhenfeng Liu ,&nbsp;Hui Lu","doi":"10.1016/j.jrras.2025.101679","DOIUrl":"10.1016/j.jrras.2025.101679","url":null,"abstract":"<div><div>Endometriosis, a prevalent chronic inflammatory gynecological disorder, is characterized by the ectopic implantation of functional endometrial tissue outside the uterine cavity and is increasingly recognized as a fibrotic condition. The fibroblast activation protein inhibitor ([¹⁸F] FAPI) represents a novel radiotracer targeting fibroblast activation protein (FAP), demonstrating significant promise in imaging both benign and malignant pathologies. This study aimed to investigate the efficacy of [¹⁸F] FAPI as a non-invasive tracer for detecting ovarian and peritoneal endometriosis.</div><div>An endometriosis model was established in Sprague-Dawley rats via autologous transplantation of uterine endometrial tissue to the contralateral ovary and abdominal wall. Small-animal PET/CT imaging was performed 60 min post-injection of Al¹⁸F-NOTA-FAPI-04. Quantitative analysis revealed significantly higher tracer uptake in ovarian endometriotic lesions (OELs; SUV_max = 2.53 ± 0.61) compared to adjacent non-lesional ovarian tissue (sOEL; 1.28 ± 0.46, P = 0.031) and contralateral ovarian tissue (CO; 1.15 ± 0.49, P = 0.016). Similarly, peritoneal endometriotic lesions (PELs) exhibited elevated uptake (SUV_max = 1.74 ± 0.15) relative to surrounding peritoneal endometriotic lesions (sPEL; 0.97 ± 0.13, P = 0.001) and abdominal wall muscle (AWM; 0.83 ± 0.12, P = 0.0004). Histopathological and immunohistochemical analyses further validated the imaging findings.</div><div>These results demonstrate that Al¹⁸F-NOTA-FAPI-04 PET/CT can effectively differentiate endometriotic lesions from normal tissues, highlighting its potential as a non-invasive diagnostic tool for endometriosis.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101679"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}