位移、伪影、厚度变化和扫描方案对放射治疗中锥束计算机断层成像质量和配准精度的影响

IF 2.5 4区综合性期刊 Q2 MULTIDISCIPLINARY SCIENCES

Journal of Radiation Research and Applied Sciences Pub Date : 2025-09-15 DOI:10.1016/j.jrras.2025.101966

Dan Chen , Qingfeng Jiang , Kui Liao, Shunlong Wu

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引用次数: 0

摘要

目的评价平面CT(pCT)-CBCT在图像引导放射治疗（IGRT）中位移、解剖厚度变化、伪影和扫描方式对锥束CT（CBCT）图像质量和配准精度的影响。方法采用Catphan 504模型和拟人头部模型分别评价图像质量和配准误差。控制幻影位移（5毫米垂直、纵向和横向），分别添加2厘米树脂丸或0.25毫米铅圈来模拟位移、解剖厚度变化和伪影。在六种模拟情景下测试了九种预设的CBCT扫描方案，以及一种可调节的最低剂量方案。分析了视觉空间分辨率、mtf10%、均匀性、对比噪声比（CNR）和配准误差（平移/旋转误差）。结果共进行180次头幻影扫描和180次头幻影扫描，获得360次配准结果。位移、解剖厚度变化、伪影和扫描方案显著影响图像质量（空间分辨率、均匀性、CNR； p < 0.05）。平移配准误差随位移、厚度变化和伪影的增加而增加，而扫描方案和配准方法对平移配准误差的影响不显著。旋转误差受位移、伪影和配准方法的影响（p < 0.05），但不受方案或厚度变化的影响。最低剂量方案显着降低了均匀性和CNR，但不影响配准精度。结论位移、解剖厚度变化和伪影严重影响CBCT图像质量和配准精度。扫描协议对图像质量有一定的调节作用，但对头部图像的配准精度没有不利影响。线性加速器的预设CBCT扫描方案需要优化，以优先考虑临床目标，同时平衡辐射暴露与登记性能。

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Impact of displacement, artifacts, thickness variations, and scanning protocols on cone-beam computed tomography image quality and registration accuracy in radiotherapy

Objectives

To evaluate the impact of displacement, anatomical thickness variations, artifacts and scanning protocols on cone-beam computed tomography(CBCT) image quality and registration accuracy of plan CT(pCT)-CBCT in image-guided radiation therapy(IGRT).

Methods

A Catphan 504 phantom and an anthropomorphic head phantom were utilized to assess image quality and registration errors, respectively. Controlled phantom displacements (5 mm vertical, longitudinal, and lateral), addition of a 2 cm resin bolus or 0.25 mm lead apron to mimic displacement, anatomical thickness variations and artifacts, respectively. Nine preset CBCT scanning protocols, in addition to an adjustable lowest-dose protocol were tested under six mimic scenarios. Visual spatial resolution, MTF10 %, uniformity, and contrast-to-noise ratio [CNR] and registration errors (translation/rotation errors) were analyzed.

Results

A total of 180 catphan and 180 head phantom scans yielded 360 registration outcomes. Displacement, anatomical thickness variation, artifacts, and scanning protocols significantly impacted image quality (spatial resolution, uniformity, CNR; p < 0.05). Translational registration errors increased with displacement, thickness variation and artifacts, while scanning protocols and registration methods exhibited no significant effect. Rotational errors were influenced by displacement, artifacts, and registration methods (p < 0.05) but not by protocols or thickness variation. The lowest-dose protocol markedly degraded uniformity and CNR without compromising registration accuracy.

Conclusions

Displacement, anatomical thickness variations, and artifacts significantly impair CBCT image quality and registration accuracy. Scanning protocols modulate image quality, but do not detrimentally affect registration accuracy in head phantom. The preset CBCT scanning protocol of linear accelerator requires optimization to prioritize clinical objectives while balancing radiation exposure with registration performance.

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来源期刊

Journal of Radiation Research and Applied Sciences MULTIDISCIPLINARY SCIENCES-

自引率

5.90%

发文量

130

审稿时长

16 weeks

期刊介绍： Journal of Radiation Research and Applied Sciences provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and applications of nuclear, radiation and isotopes in biology, medicine, drugs, biochemistry, microbiology, agriculture, entomology, food technology, chemistry, physics, solid states, engineering, environmental and applied sciences.