Journal of Radiation Research and Applied Sciences最新文献

{"title":"Investigation of effect of pitch change on radiation dose in head and abdominal computed tomography scans: A phantom study","authors":"Güneş Açıkgöz,&nbsp;Hatice Erdem","doi":"10.1016/j.jrras.2025.101691","DOIUrl":"10.1016/j.jrras.2025.101691","url":null,"abstract":"<div><h3>Purpose</h3><div>The aim of the study was to examine the pitch value, which is one of the parameters affecting the radiation dose. In both adult and pediatric head and abdominal Computed Tomography (CT) examination protocols, CTDIvol and DLP values were obtained at different pitch values using a phantom.</div></div><div><h3>Methods</h3><div>The pitch values determined automatically by the CT device for adult head, child head, adult abdomen and child abdomen scans were recorded as 0.35, 0.6, 1.25 and 1.20, respectively. Then, scans were taken at pitch values of 0.6, 0.8, 1.0, 1.2, and 1.5 for adult head and abdomen. Statistical analyses were performed using OriginPro and SPSS statistical programs.</div></div><div><h3>Results</h3><div>According to the PCA (Principal Component Analysis) method, PC1 (Principal Component) was obtained as 58.93 %, PC2 (Principal Component) as 29.41 %, and the sum of both PCs was observed to constitute 88.34 % of the total variance. In the K-Means cluster analysis, two different classes were obtained. According to the CTDIvol and DLP measurements, it was observed that the measurement with the highest PC1 score was the adult abdominal CT scan with a pitch value of 1.5.</div></div><div><h3>Conclusion</h3><div>According to the results obtained, it can be said that changing the pitch value affects the CTDIvol and DLP values, which are radiation dose indicators and found on the dose page. In addition, it can be said that it would be advantageous to use PCA and k-means cluster analysis, which are Unsupervised Machine Learning methods, on data obtained from computer-aided imaging devices such as CT.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101691"},"PeriodicalIF":1.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photon attenuation, dose rate and buildup factors of porous glasses containing GeO2","authors":"M.S. Al-Buriahi ,&nbsp;S.S. Owoeye ,&nbsp;Hind Saeed Alzahrani ,&nbsp;Norah Salem Alsaiari ,&nbsp;Imed Boukhris ,&nbsp;Elif Kemah","doi":"10.1016/j.jrras.2025.101659","DOIUrl":"10.1016/j.jrras.2025.101659","url":null,"abstract":"<div><div>In this present work, SiO₂–GeO₂–Na₂O–B₂O₃ (SiGeNaBx) glass compositions containing varying additions of GeO₂ (22, 33, 44, and 55 mol. %) coded as SiGeNaB1, SiGeNaB2, SiGeNaB3, and SiGeNaB4, respectively, were reported. The effects of variation of GeO₂ on the radiation protective properties of the developed porous glasses were then analyzed. The elemental composition showed the glasses contain elements of B (boron), O (oxygen), Si (silicon), germanium (Ge), and Na (sodium), with an increased weight percent of Ge, establishing the formulated glasses. Both mass attenuation coefficient (MAC) and mass energy-absorption coefficient (MEAC) increased with increased GeO₂ content, respectively, with SiGeNaB4 exhibiting higher MAC and MEAC values of 42.61 and 29.32 cm²g^-1, respectively, but with increased radiation intensity (<span><math><mrow><mi>Γ</mi></mrow></math></span>) lower energies. Both effective atomic number (Z_eff) and electron density (N_eff) also increased with increased GeO₂ additions at lower energies (0.015–0.1 MeV). The gamma dose rate decreased with increased thickness of glass samples for all the compositions, while SiGeNaB4 exhibited a lower dose rate, suggesting better shielding performance. Sample SiGeNaB4 also displayed a lower exposure build factor (EBF) at lower energy levels. However, in comparison to other radiation shielding glasses, the developed glasses exhibited promising properties, establishing their potential as radiation shielding materials at low photon energy.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101659"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial circ_0010074 induces cardiac inflammation to facilitate fibrosis by upregulating NLRP1 via sponging miR-214–3p with m6A modification after myocardial infarction","authors":"Yunhua Liu ,&nbsp;Xiaoyu Li ,&nbsp;Yahan Yu ,&nbsp;Wenjuan Wang ,&nbsp;Anqi Li ,&nbsp;Yunliang Yao","doi":"10.1016/j.jrras.2025.101673","DOIUrl":"10.1016/j.jrras.2025.101673","url":null,"abstract":"<div><h3>Backgrounds</h3><div>Myocardial infarction (MI) is a life-threatening coronary artery disease, and the in-hospital mortality rate of MI is up to 14.7 %. It is urgent to explore novel therapeutic targets and strategies for MI. Though circular RNAs (circRNAs) play fundamental roles in MI, the knowledge about circRNAs in MI is limited, and the effect of myocardial circ_0010074 on MI remains unknown.</div></div><div><h3>Methods</h3><div>In this study, primary murine cardiomyocytes and cardiac fibroblasts were utilized, and primary cardiomyocytes were exposed to H₂O₂ for establishing MI model <em>in vitro</em>. Besides, the regulatory effects among circRNA-microRNA (miRNA)-mRNA were identified by dual-luciferase reporter gene assay, and N⁶-methyladenosine (m⁶A) modification of circ_0010074 was detected by methylated RNA Immunoprecipitation (MeRIP).</div></div><div><h3>Results</h3><div>The investigation indicates that myocardial circ_0010074 is upregulated after MI. Moreover, myocardial circ_0010074 induces NOD-like receptor family pyrin domain-containing 1 (NLRP1) inflammation and NLRP1-mediated cardiac fibrosis after MI. Mechanistically, myocardial circ_0010074 elevates NLRP1 expressing by sponging miR-214–3p. Besides, m⁶A modification enhances circ_0010074 to sponge miR-214–3p in cardiomyocytes after MI.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that myocardial circ_0010074 triggers cardiac inflammation to facilitate fibrosis by increasing NLRP1 expression via sponging miR-214–3p depended on m⁶A modification after MI, which might provide novel therapeutic targets to dig more effective drugs for treating MI.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101673"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Al18F-NOTA-FAPI-04 PET/CT imaging for visualization and localization of ovarian and peritoneal endometriotic lesions in a rat model","authors":"Lijun Yin ,&nbsp;Qianhe Xu ,&nbsp;Ahmad Alhaskawi ,&nbsp;Yongyi Yang ,&nbsp;Jie Shi ,&nbsp;Xinhui Zhou ,&nbsp;Shi Feng ,&nbsp;Yinying Zou ,&nbsp;Guoliang Xie ,&nbsp;Weihua He ,&nbsp;Xinhui Su ,&nbsp;Zhenfeng Liu ,&nbsp;Hui Lu","doi":"10.1016/j.jrras.2025.101679","DOIUrl":"10.1016/j.jrras.2025.101679","url":null,"abstract":"<div><div>Endometriosis, a prevalent chronic inflammatory gynecological disorder, is characterized by the ectopic implantation of functional endometrial tissue outside the uterine cavity and is increasingly recognized as a fibrotic condition. The fibroblast activation protein inhibitor ([¹⁸F] FAPI) represents a novel radiotracer targeting fibroblast activation protein (FAP), demonstrating significant promise in imaging both benign and malignant pathologies. This study aimed to investigate the efficacy of [¹⁸F] FAPI as a non-invasive tracer for detecting ovarian and peritoneal endometriosis.</div><div>An endometriosis model was established in Sprague-Dawley rats via autologous transplantation of uterine endometrial tissue to the contralateral ovary and abdominal wall. Small-animal PET/CT imaging was performed 60 min post-injection of Al¹⁸F-NOTA-FAPI-04. Quantitative analysis revealed significantly higher tracer uptake in ovarian endometriotic lesions (OELs; SUV_max = 2.53 ± 0.61) compared to adjacent non-lesional ovarian tissue (sOEL; 1.28 ± 0.46, P = 0.031) and contralateral ovarian tissue (CO; 1.15 ± 0.49, P = 0.016). Similarly, peritoneal endometriotic lesions (PELs) exhibited elevated uptake (SUV_max = 1.74 ± 0.15) relative to surrounding peritoneal endometriotic lesions (sPEL; 0.97 ± 0.13, P = 0.001) and abdominal wall muscle (AWM; 0.83 ± 0.12, P = 0.0004). Histopathological and immunohistochemical analyses further validated the imaging findings.</div><div>These results demonstrate that Al¹⁸F-NOTA-FAPI-04 PET/CT can effectively differentiate endometriotic lesions from normal tissues, highlighting its potential as a non-invasive diagnostic tool for endometriosis.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101679"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of ultrasonic attenuation parameters and serum indicators on MASLD patients with liver fat degenerationality","authors":"Yan Liu ,&nbsp;Wen Kang ,&nbsp;Jingya Su ,&nbsp;Yin Yang ,&nbsp;Kui Li ,&nbsp;Juntao Yang","doi":"10.1016/j.jrras.2025.101647","DOIUrl":"10.1016/j.jrras.2025.101647","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the diagnostic value of controlled attenuation parameters combined with serum biochemical indicators for metabolic dysfunction–associated steatotic liver disease (MASLD).</div></div><div><h3>Methods</h3><div>A total of 145 patients with MASLD who visited our hospital from January 2023 to June 2024 were included. 55 healthy subjects were used as controls. The ROC curve was drawn with the CT liver/spleen ratio as the diagnostic standard, and the area under the curve was calculated to evaluate the diagnostic value of fat attenuation parameters for MASLD.</div></div><div><h3>Results</h3><div>The best cut-off value of the fat attenuation parameter for diagnosing fatty liver was 262.5 dB/m (AUROC = 0.823, sensitivity = 0.820, specificity = 0.701, P &lt; 0.05). The best cut-off values of fat attenuation parameters for diagnosing mild, moderate, and severe fatty liver were 225.5 dB/m, 267.5 dB/m, and 289.5 dB/m, respectively, with AUROC of 0.440, 0.665, and 0.808, all P &lt; 0.05. The combination of fat attenuation parameter with alanine aminotransferase or triglyceride can enhance the diagnostic value of MASLD, and the diagnostic efficacy of fat attenuation parameter combined with ALT was substantially higher, the AUROC was 0.776, 0.924, and 0.997, all P &lt; 0.05.</div></div><div><h3>Conclusion</h3><div>Ultrasound controlled attenuation parameters combined with ALT and TG have near-perfect diagnostic accuracy. for MASLD.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101647"},"PeriodicalIF":1.7,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144255094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weighted T-X Power Lomax distribution: Properties and applications in chemotherapy and economic","authors":"Mohamed A. Abd Elgawad ,&nbsp;Aleena Thampi ,&nbsp;Potluri S.S. Swetha ,&nbsp;Vasili B.V. Nagarjuna","doi":"10.1016/j.jrras.2025.101635","DOIUrl":"10.1016/j.jrras.2025.101635","url":null,"abstract":"<div><div>In this article, we propose a new extension of the Lomax distribution using the new T-X family and name it Weighted T-X power Lomax distribution. For this distribution, some statistical properties such as quantile function, moments, and order statistics are derived. In addition, for the proposed model various shapes of density curves and hazard curve were visualized. The estimation of the parameters are done through the method of Maximum Likelihood estimation and also simulation studies are carried out. The applicability of the proposed model was illustrated with real datasets. The efficiency of the model was identified by comparing it to Lomax based distributions.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101635"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal radiative flow of SWCNT+MWCNT+TiO2/Water based trihybrid nanofluid with bioconvection and Cattaneo-Christov flux model","authors":"Ahmed M. Galal ,&nbsp;Mostafa Mohamed Okasha ,&nbsp;Talib K. Ibrahim ,&nbsp;Ibtehal Alazman ,&nbsp;Nouf Abdulrahman Alqahtani ,&nbsp;Munawar Abbas ,&nbsp;Ilyas Khan","doi":"10.1016/j.jrras.2025.101662","DOIUrl":"10.1016/j.jrras.2025.101662","url":null,"abstract":"<div><div>The effect of Marangoni convective on thermal radiation flow of a SWCNT + MWCNT + TiO2/Water based ternary hybrid nanofluid across a disk in the presence of oxytactic and gyrotactic microbes is scrutinized in the current article. This article examines the Cattaneo-Christov law, which regulates the movement of heat and mass, rather than the conventional Fourier and Fick equations for examining the features of heat and mass transmission. Changes in surface tension gradients lead to the discovery of Marangoni convection. Among its many uses are crystal formation, drying silicon wafers, stabilizing soap coatings, and wielding. These novel fluids combine the bio-convection produced by microbes with the thermal features of many nanoparticles to increase the efficiency of heat transfer. This technique can optimize cooling in systems including chemical reactors, power plants, and electronic devices by improving thermal management, using less energy, and having a smaller environmental impact. Marangoni convection offers information for better cooling system performance and design when surface tension gradients are significant. A trihybrid nanofluid is created by combining water, MWCNT (multi-wall carbon nanotubes), and SWCNT and <span><math><mrow><mi>T</mi><mi>i</mi><msub><mi>O</mi><mn>2</mn></msub></mrow></math></span>. The ODE (ordinary differential equations) are solved using the Bvp4c shooting method. The findings indicate that although the microbe profiles for heat, solutal, gyrotactic, and oxytactic processes exhibit the opposing pattern, the flow field upsurges as the Marangoni convection factor upsurges. Increasing the concentration and thermal relaxation factors specifically results in a decrease in the concentration and thermal fields.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101662"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Habitat image based on enhanced MRI before transcatheter arterial chemoembolization of hepatocellular carcinoma clinical value of prognosis prediction","authors":"Qing-Long Guan ,&nbsp;Hai-Xiao Zhang ,&nbsp;Wei-Xin Ren,&nbsp;Di-wen Zhu","doi":"10.1016/j.jrras.2025.101666","DOIUrl":"10.1016/j.jrras.2025.101666","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the clinical value of predicting the 2-year progression-free survival time (PFS) in patients with hepatocellular carcinoma (HCC) before transcatheter arterial chemoembolization (TACE) based on enhanced MRI Habitat image model.</div></div><div><h3>Methods</h3><div>This study is a retrospective study that collected 114 HCC patients who received TACE treatment in the Interventional Clinic of Xinjiang Medical University from January 2022 to December 2023. The image was preprocessed (normalization, N4 calibration and image registration). The region of interest (ROI) of the registered image was sketched by ITK-SNAP software, and the characteristics of ROI were extracted with 19 characteristic parameters. Before the characteristics of the Habitat image, all pixels in the sketched ROI area should be analyzed by K-means clustering to get the best clustering number. Machine learn that obtained final characteristic parameter through a classifier algorithm to obtain a Habitat image model and an image omics model.</div></div><div><h3>Results</h3><div>Machine learning was carried out with classifiers SVM, MLP, KNN, LR and LightGBM, and the optimal classifier model parameters were selected to construct Habitat image model, imageology model and Habitat_Rad model. In the model, the diagnostic efficiency AUC value of classifier LightGBM was the highest, and the training cohort AUC value was 0.904, 0.847 and 0.925 respectively, and the validation set AUC value was 0.688 and 0.925 respectively. Habitat image segmentation is the best when K-means is 5, in which Habitat5 is usually located in the center of tumor, Habitat1 and Habitat4 are usually located in the periphery of tumor center, and Habitat2 and Habitat3 are usually located at the edge of tumor.</div></div><div><h3>Conclusion</h3><div>Comparison to existing prognostic models in HCC, Habitat_Rad is the best model to predict the survival rate of PFS after TACE, and it is considered that Habitat images can provide a new method to evaluate the spatial heterogeneity in HCC and become a new image biomarker in the future.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101666"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Induced magnetic force and bioconvection analysis in magnetized viscoelastic nanofluid under radiation effect","authors":"Nermeen Abdullah ,&nbsp;Sami Ullah Khan ,&nbsp;Kaouther Ghachem ,&nbsp;Faiza Benabdallah ,&nbsp;Badr M. Alshammari ,&nbsp;Lioua Kolsi","doi":"10.1016/j.jrras.2025.101682","DOIUrl":"10.1016/j.jrras.2025.101682","url":null,"abstract":"<div><div>The induction of the induced magnetic field with nanofluids presents novel applications in renewable energy, solar collectors and MHD power generation. This contribution aims to explore the significance of induced magnetic force in bioconvective transport of Walters B nanofluid subject to nonlinear radiated effects. The rheological behavior of non-Newtonian material is described by Walters B fluid. The porous saturated surface endorsed the flow. The investigation considered the aspects of magnetohydrodynamics (MHD) features and additional heat sources. The modification in heat and mass transfer equations is subject to implementation of famous Cattaneo-Christov model. Uniform convective thermal constraints are imposed to make the model more realistic and novel. The novelty of current analysis is subject to decomposition of viscoelastic nanofluid with assessment of bioconvection under the influence of induced magnetic flow, providing significant interest in advanced engineering systems and biomedical applications. The comprehensive framework is solved numerically via shooting technique. Physical results against the key parameters are evaluated graphically and studied comprehensively. It has been examined that magnetic parameter increases the velocity profile as well as induced magnetic induction. The velocity profile retarded due to viscoelastic parameter. Furthermore, concentration profiles are reduced due to concentration relaxation number. The findings present valuable insights into optimization of thermal systems, industrial heating and cooling processes and biotechnological applications like biofuels, fertilizers, and design of microfluidic devices. Furthermore, this results insights into magnetized viscoelastic nanofluid with heat transfer induction of magnetic force provide fundamental applications in the precision control systems and magnetic resonance imaging (MRI).</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101682"},"PeriodicalIF":1.7,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-analysis of margins and outcomes after transoral robotic surgery in human papillomavirus-associated oropharyngeal cancer","authors":"Justin Choi ,&nbsp;Fasil Mathews ,&nbsp;Richard Rosenfeld ,&nbsp;Ofer Azoulay ,&nbsp;Krishnamurthi Sundaram","doi":"10.1016/j.jrras.2025.101651","DOIUrl":"10.1016/j.jrras.2025.101651","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the effect of margin distance on outcomes in patients with HPV + oropharyngeal squamous cell carcinoma (OPSCC) after transoral robotic surgery (TORS).</div></div><div><h3>Data sources</h3><div>Obtained from a database search of PubMed, EMBASE, and Google Scholar using an <em>a priori</em> protocol with dual independent evaluation for inclusion, risk of bias assessment, and extraction of data for analysis. Articles that reported surgical margin distance and recurrence data after TORS in patients with HPV + OPSCC were included.</div></div><div><h3>Review methods</h3><div>Random-effects meta-analysis was used to pool data from studies. Rates of local, regional, and distance recurrences were compared across three groups: &lt;1 mm, 1–2 mm, and &gt;2 mm.</div></div><div><h3>Results</h3><div>A total of 7 articles comprising 1150 patients were included in the analysis. The majority were tonsil primary (54 %), T1-T2 (94 %), and N+ (86 %). Adjuvant radiation with or without chemotherapy was given to 846 patients (74 %). Most patients had a &gt;2 mm margin after resection (72 %). Local, regional, or distant recurrence was observed in 14 % of patients with &lt;1 mm margin, 10 % of patients with 1–2 mm margin, and 6 % of patients with &gt;2 mm margin. There were no statistically significant differences in rates of any type of recurrence based on margin status.</div></div><div><h3>Conclusion</h3><div>Low rates of recurrence were observed after TORS in patients with HPV + OPSCC regardless of margin distance. Most patients received adjuvant therapy post-operatively at variable rates, obscuring the true effect of margin status on oncologic outcomes. Further investigation of de-escalation protocols in controlled clinical trials are needed to reduce uncertainty and to provide information on disease-free and overall survival rates.</div></div>","PeriodicalId":16920,"journal":{"name":"Journal of Radiation Research and Applied Sciences","volume":"18 3","pages":"Article 101651"},"PeriodicalIF":1.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}