Journal of The Royal Society Interface最新文献

Generative design as a tool to analyse the uncertain loading regimes of intricate skeletal structures. 生成设计是一种分析复杂骨架结构不确定载荷的工具。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-14 DOI: 10.1098/rsif.2025.0023

John Michael Racy, Bart Boom, Adam Summers

引用次数: 0

Advection and diffusion in perivascular and extracellular spaces in the brain. 脑内血管周围和细胞外空间的平流和扩散。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-21 DOI: 10.1098/rsif.2025.0010

Yisen Guo, Keelin Quirk, Douglas H Kelley, John H Thomas

{"title":"Advection and diffusion in perivascular and extracellular spaces in the brain.","authors":"Yisen Guo, Keelin Quirk, Douglas H Kelley, John H Thomas","doi":"10.1098/rsif.2025.0010","DOIUrl":"10.1098/rsif.2025.0010","url":null,"abstract":"Knowledge of the relative importance of advection and diffusion in clearing waste from the brain has been elusive, especially concerning the extracellular space (ECS). With local and global computational models of the mouse brain, we explore how the presence or absence of advection in the ECS affects solute transport. Without advection in the ECS, clearance would occur by diffusion into flowing cerebrospinal fluid in perivascular spaces (PVSs) or elsewhere, but we find this process to be severely limited by build-up of solute in the PVSs. We simulate flow in the ECS driven by a pressure drop between arteriole and venule PVSs, which enhances clearance considerably. To assess the relative importance of advection and diffusion, we introduce a local Péclet number [Formula: see text], a dimensionless scalar field. For our simulations, [Formula: see text] through much of the ECS but [Formula: see text] near PVSs near the brain surface. This local dominance of advection in the ECS establishes a clearance mechanism markedly different from that produced by diffusion alone. In network simulations that explore different parameter values and efflux routes, the pressures needed to drive the PVS flows measured in vivo are unrealistically large for most cases lacking ECS flow. Collectively, our models indicate that a flow in the ECS is necessary to explain experimental measurements and maintain homeostasis.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20250010"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092104/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wing extension-flexion coupled aeroelastic effects improve avian gliding performance. 机翼伸屈耦合气动弹性效应提高了鸟类的滑翔性能。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1098/rsif.2024.0753

Jasmin C M Wong, Vaibhav Joshi, Rajeev K Jaiman, Douglas L Altshuler

{"title":"Wing extension-flexion coupled aeroelastic effects improve avian gliding performance.","authors":"Jasmin C M Wong, Vaibhav Joshi, Rajeev K Jaiman, Douglas L Altshuler","doi":"10.1098/rsif.2024.0753","DOIUrl":"https://doi.org/10.1098/rsif.2024.0753","url":null,"abstract":"During flight, birds instigate remarkably large changes in wing shape, commonly termed 'wing morphing'. These changes in shape, particularly extension-flexion, have been well documented to influence the production of aerodynamic forces. However, it is unknown how wing stiffness changes as a result of the structural rearrangements needed for morphing. We address this gap in knowledge through mechanical testing of in situ flight feathers in anaesthetized pigeons and found that while the most distal portion of the feathered wing remained unaffected, proximal areas saw an increase in out-of-plane stiffness due to wing folding. Following this, we used computational fluid-structure interaction simulations to evaluate how this morphing-coupled change in stiffness might modulate local flow patterns to affect aerodynamic performance. We found that flexible wings perform better than entirely rigid wings as an increase in near-wall vorticity delayed flow separation. Furthermore, an increase in stiffness in a folded wing during high-speed flight prevented the reduction in lift seen in more flexible cases caused by aeroelastic flutter modes destructively interfering with shed leading-edge vortices. Collectively, these results reveal that mechanical changes coupled with wing morphing can provide a speed-dependent mechanism to enhance flight performance.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240753"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrical wave generation and spatial organization in uterine tissue. 子宫组织中的电波产生与空间组织。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-14 DOI: 10.1098/rsif.2024.0638

Shawn A Means, Jagir R Hussan, Amy S Garrett, Leo K Cheng, Alys Rachel Clark

{"title":"Electrical wave generation and spatial organization in uterine tissue.","authors":"Shawn A Means, Jagir R Hussan, Amy S Garrett, Leo K Cheng, Alys Rachel Clark","doi":"10.1098/rsif.2024.0638","DOIUrl":"10.1098/rsif.2024.0638","url":null,"abstract":"Healthy uterine function requires coordinated and spatially organized contractions over the menstrual cycle (oestrus in animals) and at term in pregnancy. The underlying mechanisms triggering and coordinating uterine contractions, without a distinct pacemaking region, are poorly understood. Potentially, gap-junction coupling between excitable smooth muscle cells themselves or between electrically passive cells (telocytes or fibroblasts) and excitable cells may be key. Here, we present a lattice-tissue model of coupled excitable and passive cells to investigate a potential mechanism of coordinated tissue contraction. Bifurcation analysis of cell pairs quantifies parameter windows exhibiting oscillatory behaviour. Within these windows, we demonstrate conditions when the magnitude and spatial distribution of coupling strengths generate electrical waves. Energy-based analysis of excitable cells provides quantification of intercellular energy differences cells required for spontaneous wave generation. Our model suggests passive cells must rest at a membrane voltage sufficiently higher than smooth muscle cells to trigger activity and that coupling between excitable and passive cells in spatially concentrated regions could influence the direction of tissue-wide electrical waves. This suggests that both the total number of gap junctions and their spatial expression may play a role in coordinating uterine contractility.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240638"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12076165/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bayesian networks for network inference in biology. 生物学中网络推理的贝叶斯网络。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1098/rsif.2024.0893

James Hammond, V Anne Smith

{"title":"Bayesian networks for network inference in biology.","authors":"James Hammond, V Anne Smith","doi":"10.1098/rsif.2024.0893","DOIUrl":"https://doi.org/10.1098/rsif.2024.0893","url":null,"abstract":"Bayesian networks (BNs) have been used for reconstructing interactions from biological data, in disciplines ranging from molecular biology to ecology and neuroscience. BNs learn conditional dependencies between variables, which best 'explain' the data, represented as a directed graph which approximates the relationships between variables. In the 2000s, BNs were a popular method that promised an approach capable of inferring biological networks from data. Here, we review the use of BNs applied to biological data over the past two decades and evaluate their efficacy. We find that BNs are successful in inferring biological networks, frequently identifying novel interactions or network components missed by previous analyses. We suggest that as false positive results are underreported, it is difficult to assess the accuracy of BNs in inferring biological networks. BN learning appears most successful for small numbers of variables with high-quality datasets that either discretize the data into few states or include perturbative data. We suggest that BNs have failed to live up to the promise of the 2000s but that this is most likely due to experimental constraints on datasets, and the success of BNs at inferring networks in a variety of biological contexts suggests they are a powerful tool for biologists.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240893"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Behavioural risk models explain locomotor and balance changes when walking at virtual heights. 行为风险模型解释了在虚拟高度行走时运动和平衡的变化。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-14 DOI: 10.1098/rsif.2024.0832

Nooshin Seddighi, Nicholas J Woo, Jaylie Montoya, Nicholas Kreter, Mindie Clark, A Mark Williams, Tiphanie E Raffegeau, Peter C Fino

{"title":"Behavioural risk models explain locomotor and balance changes when walking at virtual heights.","authors":"Nooshin Seddighi, Nicholas J Woo, Jaylie Montoya, Nicholas Kreter, Mindie Clark, A Mark Williams, Tiphanie E Raffegeau, Peter C Fino","doi":"10.1098/rsif.2024.0832","DOIUrl":"10.1098/rsif.2024.0832","url":null,"abstract":"Walking in daily life requires humans to adapt to environments that can influence one's fear of falling and anxiety about a potential fall. In such environments, individuals may adopt compensatory locomotor and balance changes to maintain a constant expected risk function equal to the product of the probability of some event (e.g. a fall) and the cost of that event (e.g. injury or death). Here, we examined whether locomotor behaviours broadly align with this risk model in two experiments with height-related threats in immersive virtual reality. In Experiment 1, we examined how individuals change their locomotor trajectory while walking along a straight high-elevation walkway. In Experiment 2, we examined how individuals change trajectory and balance control during curved walking where the location of high elevation threat varied. Participants adopted two behaviours that decreased their probability of falling off the edge and aligned with the risk-based model: participants altered their proximity to perceived threats that pose high costs (e.g. a high-elevation ledge), and decreased mediolateral centre of mass velocity when that was not possible. These findings suggest that individuals alter locomotor behaviour to change the probability of falling based on the perceived cost of that fall.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240832"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12074806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Human shape perception spontaneously discovers the biological origin of novel, but natural, stimuli. 人类的形状感知自发地发现了新奇但自然的刺激的生物起源。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-21 DOI: 10.1098/rsif.2024.0931

Kira Isabel Dehn, Guido Maiello, Frieder Tom Hartmann, Yaniv Morgenstern, Sara Joy Hawkins, Thomas Offner, Joshua Walter, Thomas Hassenklöver, Ivan Manzini, Roland W Fleming

{"title":"Human shape perception spontaneously discovers the biological origin of novel, but natural, stimuli.","authors":"Kira Isabel Dehn, Guido Maiello, Frieder Tom Hartmann, Yaniv Morgenstern, Sara Joy Hawkins, Thomas Offner, Joshua Walter, Thomas Hassenklöver, Ivan Manzini, Roland W Fleming","doi":"10.1098/rsif.2024.0931","DOIUrl":"10.1098/rsif.2024.0931","url":null,"abstract":"Humans excel at categorizing objects by shape. This facility involves identifying shape features that objects have in common with other members of their class and relies-at least in part-on semantic/cognitive constructs. For example, plants sprout branches, fish grow fins, shoes are moulded to our feet. Can humans parse shapes according to the processes that give shapes their key characteristics, even when such processes are hidden? To answer this, we investigated how humans perceive the shape of cells from the olfactory system of Xenopus laevis tadpoles. These objects are novel to most humans yet occur in nature and cluster into classes following their underlying biological function. We reconstructed three-dimensional (3D) cell models through 3D microscopy and photogrammetry, then conducted psychophysical experiments. Human participants performed two tasks: they arranged 3D-printed cell models by similarity and rated them along eight visual dimensions. Participants were highly consistent in their arrangements and ratings and spontaneously grouped stimuli to reflect the cell classes, unwittingly revealing the underlying processes shaping these forms. Our findings thus demonstrate that human perceptual organization mechanisms spontaneously parse the biological systematicities of never-before-seen, natural shapes. Integrating such human perceptual strategies into automated systems may enhance morphology-based analysis in biology and medicine.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240931"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays. 动态夹紧诱导滑动试验中固定丝的旋转到跳动转变。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1098/rsif.2024.0859

Amir Khosravanizadeh, Serge Dmitrieff

{"title":"Dynamic clamping induces rotation-to-beating transition of pinned filaments in gliding assays.","authors":"Amir Khosravanizadeh, Serge Dmitrieff","doi":"10.1098/rsif.2024.0859","DOIUrl":"https://doi.org/10.1098/rsif.2024.0859","url":null,"abstract":"We used numerical simulations to investigate how properties of motor proteins control the dynamical behaviour of driven flexible filaments. A filament on top of a patch of anchored motor proteins is pinned at one end, a setup referred to as a spiral gliding assay. There exists a variety of motor proteins with different properties. We found that when these properties are changed, this system generally can show three different regimes: (i) fluctuation, where the filament undergoes random fluctuations because the motors are unable to bend it, (ii) rotation, in which the filament bends and then moves continuously in one direction, and (iii) beating, where the filament rotation direction changes over time. We found that the transition between fluctuation and rotation occurs when motors exert a force sufficient to buckle the filament. The threshold force coincides with the second buckling mode of a filament undergoing a continuously distributed load. Moreover, we showed that when motors near the pinning point work close to their stall force, they cause dynamic clamping, leading to the beating regime. Rather than being imposed by experimental conditions, this clamping is transient and results from the coupling between filament mechanics and the collective behaviour of motors.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240859"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143971065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active droplets controlled by enzymatic reactions. 由酶促反应控制的活性液滴。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1098/rsif.2024.0803

Jacques Fries, Javier Diaz, Marie Jardat, Ignacio Pagonabarraga, Pierre Illien, Vincent Dahirel

{"title":"Active droplets controlled by enzymatic reactions.","authors":"Jacques Fries, Javier Diaz, Marie Jardat, Ignacio Pagonabarraga, Pierre Illien, Vincent Dahirel","doi":"10.1098/rsif.2024.0803","DOIUrl":"https://doi.org/10.1098/rsif.2024.0803","url":null,"abstract":"The formation of condensates is now considered a major organizing principle of eukaryotic cells. Several studies have recently shown that the properties of these condensates are affected by enzymatic reactions. We propose here a simple generic model to study the interplay between two enzyme populations and a two-state protein. In one state, the protein forms condensed droplets through attractive interactions, while in the other state, the proteins remain dispersed. Each enzyme catalyses the production of one of these two protein states only when reactants are in its vicinity. A key feature of our model is the explicit representation of enzyme trajectories, capturing the fluctuations in their local concentrations. The spatially dependent growth rate of droplets naturally arises from the stochastic motion of these explicitly modelled enzymes. Using two complementary numerical methods-(i) Brownian dynamics simulations and (ii) a hybrid method combining Cahn-Hilliard-Cook diffusion equations with Brownian dynamics for the enzymes-we investigate how enzyme concentration and dynamics influence the evolution with time and the steady-state number and size of droplets. Our results show that the concentration and diffusion coefficient of enzymes govern the formation and size-selection of biocondensates.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240803"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12056557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the evolutionary adaptations of the unique seahorse tail's muscle architecture through in silico modelling and robotic prototyping. 通过计算机建模和机器人原型，探索独特海马尾巴肌肉结构的进化适应性。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-05-01 Epub Date: 2025-05-07 DOI: 10.1098/rsif.2024.0876

Dries Marzougui, Riddhi Das, Barbara Mazzolai, Dominique Adriaens, Francis Wyffels

{"title":"Exploring the evolutionary adaptations of the unique seahorse tail's muscle architecture through in silico modelling and robotic prototyping.","authors":"Dries Marzougui, Riddhi Das, Barbara Mazzolai, Dominique Adriaens, Francis Wyffels","doi":"10.1098/rsif.2024.0876","DOIUrl":"https://doi.org/10.1098/rsif.2024.0876","url":null,"abstract":"Seahorses possess a unique tail muscle architecture that enables efficient grasping and anchoring onto objects. This prehensile ability is crucial for their survival, as it allows them to resist currents, cling to mates during reproduction and remain camouflaged to avoid predators. Unlike in any other fish, the muscles of the seahorse tail form long, parallel sheets that can span up to 11 vertebral segments. This study investigates how this distinctive muscle arrangement influences the mechanics of prehension. Through in silico simulations validated by a three-dimensional-printed prototype, we reveal the complementary roles of these elongated muscles alongside shorter, intersegmental muscles. Furthermore, we show that muscles spanning more segments allow greater contractile forces and provide more efficient force-to-torque transmissions. Our findings confirm that the elongated muscle-tendon organization in the seahorse tail provides a functional advantage for grasping, offering insights into the evolutionary adaptations of this unique tail structure.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 226","pages":"20240876"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0