Journal of The Royal Society Interface最新文献

Passive ankle exoskeleton assistance selectively modulates triceps surae neural control during balance. 被动踝关节外骨骼辅助选择性调节三头肌表面神经控制在平衡。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2025.1305

Raphaël Hamard, François Hug, Taylor J M Dick

{"title":"Passive ankle exoskeleton assistance selectively modulates triceps surae neural control during balance.","authors":"Raphaël Hamard, François Hug, Taylor J M Dick","doi":"10.1098/rsif.2025.1305","DOIUrl":"https://doi.org/10.1098/rsif.2025.1305","url":null,"abstract":"Wearable assistive devices have potential to improve human balance, but their effectiveness remains limited by an incomplete understanding of how mechanical assistance influences neuromuscular control. This study aimed to determine the neural adaptations in the control of lower leg muscles in response to passive ankle exoskeleton assistance during standing balance tasks with varying levels of difficulty. Lower limb kinematics and kinetics were recorded to assess changes in joint dynamics and balance performance. Neural drive to the muscles was assessed by decomposing high-density electromyography signals into motor unit spike trains. Ankle exoskeleton assistance, provided by a simple spring-loaded passive device, did not alter or improve balance performance and had minimal effects on lower limb kinematics. However, exoskeleton assistance affected triceps surae neural control, but only in the soleus, by reducing neural drive, while the gastrocnemii showed no detectable changes in neural control. Together, these results demonstrate that passive exoskeleton assistance alters neural control of the triceps surae in a muscle-specific manner during balance. Understanding muscle-specific adaptations can support more effective exoskeleton design and the development of their control strategies informed by myoelectrical signals.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0592

Timon Gehrmann, Przemyslaw Gorzelak, Susanna Labisch, Jan-Henning Dirks

{"title":"Stress-correlated stereom organization in the echinoid tubercle reveals hierarchical mechanical integration.","authors":"Timon Gehrmann, Przemyslaw Gorzelak, Susanna Labisch, Jan-Henning Dirks","doi":"10.1098/rsif.2026.0592","DOIUrl":"https://doi.org/10.1098/rsif.2026.0592","url":null,"abstract":"Echinoid tests consist of a highly porous skeletal microstructure (stereom) optimized in terms of functional performance. One of the most mechanically demanding components of the test is the tubercle, which forms the mechanical interface between the test plates and spines and is subjected to complex loads generated by motion of the spine. However, the mechanical behaviour of tubercles under realistic loading conditions remains poorly explored. Here, we investigate the tubercle of Prionocidaris baculosa using high-resolution X-ray microscopy and finite-element analysis to simulate physiologically relevant loading, identify the main stress directions, and assess mechanical efficiency through topology optimization. By correlating experimental and numerical results, we quantify the relationship between stress distributions and stereom organization, providing new insights into the mechanical complexity of echinoid skeletons. We found a strong correlation between experimentally determined density and different stress parameters (von Mises stress, principal stress trajectories and mean normal stress), supporting the hypothesis of a functionally graded and mechanically optimized stereom architecture. These findings highlight the echinoid skeleton as a naturally optimized, load-adaptive structure with potential relevance for bioinspired design. In particular, stereom-inspired architectures could inform additive manufacturing approaches, enabling lightweight and material-efficient components with tailored mechanical performance derived from a single material.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent neural chemical reaction networks trained to switch dynamical behaviours through learned bifurcations. 循环神经化学反应网络训练切换动态行为通过学习分叉。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0169

Alexander Dack, Tomislav Plesa, Thomas E Ouldridge

{"title":"Recurrent neural chemical reaction networks trained to switch dynamical behaviours through learned bifurcations.","authors":"Alexander Dack, Tomislav Plesa, Thomas E Ouldridge","doi":"10.1098/rsif.2026.0169","DOIUrl":"https://doi.org/10.1098/rsif.2026.0169","url":null,"abstract":"Both natural and synthetic chemical systems not only exhibit a range of non-trivial dynamics, but also transition between qualitatively different dynamical behaviours as environmental parameters change. Such transitions are called bifurcations. Here, we show that recurrent neural chemical reaction networks (RNCRNs), a class of chemical reaction networks based on recurrent artificial neural networks that can be trained to reproduce a given dynamical behaviour, can also be trained to exhibit bifurcations. First, we show that RNCRNs can inherit some bifurcations defined by smooth ordinary differential equations (ODEs). Second, we demonstrate that the RNCRN can be trained to infer bifurcations that allow it to approximate different target behaviours within different regions of parameter space, without explicitly providing the bifurcation itself in the training. These behaviours can be specified using target ODEs that are discontinuous with respect to the parameters, or even simply by specifying certain desired dynamical features in certain regions of the parameter space. To achieve the latter, we introduce an ODE-free algorithm for training the RNCRN to display designer oscillations, such as a heart-shaped limit cycle or two coexisting limit cycles.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect. 孤立性室间隔缺损儿童血流动力学的数学模拟。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0187

Mitchel J Colebank, Alfonso Limon, Anthony Chang, Brandon Wong, Wyman Lai, Hamilton Baker

{"title":"Mathematical simulations of paediatric haemodynamics in isolated ventricular septal defect.","authors":"Mitchel J Colebank, Alfonso Limon, Anthony Chang, Brandon Wong, Wyman Lai, Hamilton Baker","doi":"10.1098/rsif.2026.0187","DOIUrl":"https://doi.org/10.1098/rsif.2026.0187","url":null,"abstract":"Computer modelling of the cardiovascular system has the potential to revolutionize personalized medical care. This is especially promising for congenital heart defects, such as ventricular septal defect (VSD), a hole between the two ventricles of the heart. However, relatively few studies have built computer models for VSD, nor have they considered how natural adaptation to the cardiovascular system with age might interact with the presence of a small-, medium- or large-sized VSD. Here, we combine a lumped-parameter model of the cardiovascular system with two key modelling components: a size-dependent resistance dictating shunt flow between the two ventricles and age-dependent scaling relationships for the systemic and pulmonary circulations. Our results provide insight into changes in haemodynamic conditions with various VSD sizes. We investigate the combined effects of VSD size, vascular parameters and age, showing distinct differences with these three factors. This study lays the necessary foundation for studying VSD and towards building digital shadows and digital twins for managing VSD in paediatrics.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coffee-ring effect enables correlative super-resolution imaging of label-free chromosomes. 咖啡环效应使无标记染色体的相关超分辨率成像成为可能。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0072

Yanxin Dou, Valerie S T Goh, Thomas Osipowicz, Christelle E L Chua

引用次数: 0

A data-driven framework to identify restenosis-prone regions in femoral arteries from geometric and inflow waveform parameters. 从几何和流入波形参数中识别股动脉再狭窄易发区域的数据驱动框架。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0109

Chotirawee Chatpattanasiri, Federica Ninno, Vanessa Diaz-Zuccarini, Stavroula Balabani

{"title":"A data-driven framework to identify restenosis-prone regions in femoral arteries from geometric and inflow waveform parameters.","authors":"Chotirawee Chatpattanasiri, Federica Ninno, Vanessa Diaz-Zuccarini, Stavroula Balabani","doi":"10.1098/rsif.2026.0109","DOIUrl":"https://doi.org/10.1098/rsif.2026.0109","url":null,"abstract":"Haemodynamic indices derived from computational fluid dynamics (CFD), such as time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI), are closely associated with restenosis risk in peripheral arterial disease (PAD). We present a machine learning-reduced order modelling (ML-ROM) framework to predict critical, restenosis-prone, haemodynamic regions accounting for both vessel geometries and inlet flow waveforms. We generated 500 parameterized virtual femoral-artery geometries, each paired with a synthetic physiologically realistic inflow waveform. CFD was used to obtain the wall shear stress (WSS) distribution, from which TAWSS and OSI were computed. Critical regions were then defined by applying different thresholding criteria based on TAWSS and OSI, as found in the literature. These were then used to construct ROMs using Proper Orthogonal Decomposition (POD), and to train ML models from which the critical regions could be reconstructed. Four ML architectures were explored: a geometric-parameter-only model and three alternatives that also incorporate inflow waveform information via Fourier coefficients, long short-term memory (LSTM), and convolutional neural networks (CNN). The Fourier models achieved the highest predictive performance, with the median values of balanced accuracy (BA) exceeding 0.92 across all critical-region definitions. The model also offered a substantial speed-up ratio of the order of 109 compared with traditional CFD.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diverse effects of side reactions on the persistence of autocatalytic cycles. 副反应对自催化循环持续性的不同影响。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0308

Zhen Peng, Emily Spencer, David Baum

{"title":"The diverse effects of side reactions on the persistence of autocatalytic cycles.","authors":"Zhen Peng, Emily Spencer, David Baum","doi":"10.1098/rsif.2026.0308","DOIUrl":"https://doi.org/10.1098/rsif.2026.0308","url":null,"abstract":"A key criticism of metabolism-first theories of abiogenesis is that, in the absence of specialized catalysts, side reactions would convert too many autocatalysts to inert by-products for autocatalytic systems to persist. Here, we use algebraic analysis and numerical simulations to explore the effects of side reactions on the persistence of simple autocatalytic systems. For an autocatalytic reaction coupled to a side reaction, whenever a component reaction is strictly irreversible, which is technically impossible but frequently considered an acceptable approximation, side reactions harm autocatalytic systems. But if all reactions are assumed reversible, perhaps with unequal forward and reverse rate constants, side reactions can have a wide range of effects-they can be harmful, neutral, beneficial, or harmful in the short term but beneficial in the longer term. These effects arise in the presence of reversible reactions, because side products can also serve as a reservoir from which autocatalysts can be re-derived. We then use algebraic analysis to confirm that such diverse effects also apply to a larger autocatalytic cycle coupled to more side reactions. Our results show that the effects of side reactions on autocatalytic systems do not provide sufficient grounds to reject metabolism-first models.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: 'Sequential buckling mechanics of the ermine moth's aeroelastic tymbal: an origami-like creased shell analogue' (2026) by Mendoza Nava et al. 更正:“顺序屈曲貂蛾的气动弹性力学铜鼓:折纸皱壳模拟”(2026),门多萨纳瓦等。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0946

Hernaldo Mendoza Nava, Marc Holderied, Alberto Pirrera, Rainer Maria Johannes Groh

引用次数: 0

Personalized haemodynamic modelling for non-invasive quantification of arterial stiffness in the human vasculature. 个性化血流动力学建模，用于非侵入性地量化人体血管系统的动脉硬度。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2025.1318

Xiangdong Zhang, Dan Wu, Fen Miao, Jiajie Zhong, Fan Yu, Xuejiao Zhang, Hao Liu, Ye Li

{"title":"Personalized haemodynamic modelling for non-invasive quantification of arterial stiffness in the human vasculature.","authors":"Xiangdong Zhang, Dan Wu, Fen Miao, Jiajie Zhong, Fan Yu, Xuejiao Zhang, Hao Liu, Ye Li","doi":"10.1098/rsif.2025.1318","DOIUrl":"https://doi.org/10.1098/rsif.2025.1318","url":null,"abstract":"Arterial stiffness is a pivotal predictor of cardiovascular events, yet its in vivo characterization remains elusive because arterial wall mechanics cannot be directly measured. Conventional inverse approaches require high-resolution imaging to resolve wall motion, restricting their clinical applicability. Here, we present a non-invasive computational framework that infers regional arterial stiffness solely from routinely acquired pressure and blood flow velocity waveforms by leveraging personalized one-dimensional haemodynamic models of the human arterial network. Patient-specific models were constructed for 21 individuals with hypertension using stroke volume, arterial diameters, brachial pressures and carotid flow profiles. Regional stiffness parameters were identified through optimization to reconcile simulated and measured haemodynamics, and validated against brachial-ankle pulse wave velocity. The inferred stiffness demonstrated strong concordance with clinical measurements (r = 0.81; standard error = 279 cm s)-1. Longitudinal evaluation in 13 patients further revealed therapy-dependent remodelling, with calcium channel blockers selectively reducing pathological stiffening while preserving compliant vessels. Together, these results establish model-based inversion of standard haemodynamic data as a practical, scalable approach for quantifying arterial stiffness, enabling individualized cardiovascular risk assessment and treatment monitoring.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

When imitation meets exploration: quantifying social efficiency deficits (SED) in vaccination behaviour. 当模仿遇到探索：量化接种行为中的社会效率缺陷（SED）。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-10-14 DOI: 10.1098/rsif.2026.0682

Akhil Kumar Srivastav, Chen Shen, Jun Tanimoto

{"title":"When imitation meets exploration: quantifying social efficiency deficits (SED) in vaccination behaviour.","authors":"Akhil Kumar Srivastav, Chen Shen, Jun Tanimoto","doi":"10.1098/rsif.2026.0682","DOIUrl":"https://doi.org/10.1098/rsif.2026.0682","url":null,"abstract":"Vaccination behaviour plays a critical role in shaping epidemic dynamics, yet the societal consequences of decentralized vaccination decisions remain difficult to quantify. We develop a behavioural-epidemiological framework that combines adaptive vaccination dynamics, behavioural exploration and socially desirable vaccination strategies. To evaluate the societal impact of vaccination behaviour, we introduce the social efficiency deficit (SED), a novel metric that quantifies the welfare loss arising from decentralized vaccination decisions and measures the gap between individual incentives and collective epidemic-control objectives. Numerical simulations and global sensitivity analysis reveal that transmission intensity, waning immunity, vaccination costs, compliance and behavioural exploration are key determinants of epidemic outcomes and social welfare. In particular, behavioural exploration promotes sustained vaccination uptake, suppresses infection prevalence and can reduce social inefficiency by bringing behavioural outcomes closer to socially desirable levels. The proposed framework provides a quantitative approach for assessing vaccination-related social dilemmas and offers new insights for designing effective and socially efficient public health interventions.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 243","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0