Journal of The Royal Society Interface最新文献

A predictive surrogate model of blood haemodynamics for patient-specific carotid artery stenosis.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsif.2024.0774

Mostafa Barzegar Gerdroodbary, Sajad Salavatidezfouli

{"title":"A predictive surrogate model of blood haemodynamics for patient-specific carotid artery stenosis.","authors":"Mostafa Barzegar Gerdroodbary, Sajad Salavatidezfouli","doi":"10.1098/rsif.2024.0774","DOIUrl":"10.1098/rsif.2024.0774","url":null,"abstract":"In this study, the haemodynamic factors inside the patient-specific carotid artery with stenosis are evaluated via a predictive surrogate model. The technique of proper orthogonal decomposition (POD) is used for reducing the order of the main model and consequently, the long short-term memory is employed for the prediction of main blood flow parameters, i.e. blood velocity and pressure along the patient-specific carotid artery with stenosis. The efficiency of the proposed machine learning technique has been evaluated in patient-specific carotid arteries with/without stenosis. Besides, the reconstruction error analysis is performed for different POD mode numbers. Our results demonstrate that the value of blood velocity at different stages of the cardiac cycle has a great impact on the efficiency of the proposed method for the estimation of blood haemodynamics. The presence of stenosis inside the patient-specific carotid artery intensifies the complexity of the blood flow, and consequently, the magnitude of the errors for the prediction is increased when the stenosis exists in the patient-specific carotid artery.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240774"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolution of trust in the N-player trust game with transformation incentive mechanism.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI: 10.1098/rsif.2024.0726

Yuyuan Liu, Lichen Wang, Ruqiang Guo, Shijia Hua, Linjie Liu, Liang Zhang, The Anh Han

{"title":"Evolution of trust in the N-player trust game with transformation incentive mechanism.","authors":"Yuyuan Liu, Lichen Wang, Ruqiang Guo, Shijia Hua, Linjie Liu, Liang Zhang, The Anh Han","doi":"10.1098/rsif.2024.0726","DOIUrl":"10.1098/rsif.2024.0726","url":null,"abstract":"Trust game is commonly used to study the evolution of trust among unrelated individuals. It offers valuable insights into human interactions in a range of disciplines, including economics, sociology and psychology. Previous research has revealed that reward and punishment systems can effectively promote the evolution of trust. However, these investigations overlook the gaming environment, leaving unresolved the optimal conditions for employing distinct incentives to effectively facilitate trust level. To bridge this gap, we introduce a transformation incentive mechanism in an N-player trust game, where trustees are given different forms of incentives depending on the number of trustees in the group. Using the Markov decision process approach, our research shows that as incentives increase, the level of trust rises continuously, eventually reaching a high level of coexistence between investors and trustworthy trustees. Specifically, in the case of smaller incentives, rewarding trustworthy trustees is more effective. Conversely, in the case of larger incentives, punishing untrustworthy trustees is more effective. Additionally, we find that moderate incentives have a positive impact on increasing the average payoff within the group.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240726"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0860

Tom White, Arístides López-Márquez, Carmen Badosa, Ceclila Jimenez-Mallebrera, Josep Samitier, Marina Inés Giannotti, Anna Lagunas

{"title":"Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies.","authors":"Tom White, Arístides López-Márquez, Carmen Badosa, Ceclila Jimenez-Mallebrera, Josep Samitier, Marina Inés Giannotti, Anna Lagunas","doi":"10.1098/rsif.2024.0860","DOIUrl":"10.1098/rsif.2024.0860","url":null,"abstract":"Changes in the mechanical properties of the extracellular matrix (ECM) are a hallmark of disease. Due to its relevance, several in vitro models have been developed for the ECM, including cell-derived matrices (CDMs). CDMs are decellularized natural ECMs assembled by cells that closely mimic the in vivo stromal fibre organization and molecular content. Here, we applied atomic force microscopy-force spectroscopy (AFM-FS) to evaluate the nanomechanical properties of CDMs obtained from patients diagnosed with collagen VI-related congenital muscular dystrophies (COL6-RDs). COL6-RDs are a set of neuromuscular conditions caused by pathogenic variants in any of the three major COL6 genes, which result in deficiency or dysfunction of the COL6 incorporated into the ECM of connective tissues. Current diagnosis includes the genetic confirmation of the disease and categorization of the phenotype based on maximum motor ability, as no direct correlation exists between genotype and phenotype of COL6-RDs. We describe differences in the elastic modulus (E) among CDMs from patients with different clinical phenotypes, as well as the restoration of E in CDMs obtained from genetically edited cells. Results anticipate the potential of the nanomechanical analysis of CDMs as a complementary clinical tool, providing phenotypic information about COL6-RDs and their response to gene therapies.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240860"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flipons enable genomes to learn by intermediating the exchange of energy for information.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI: 10.1098/rsif.2025.0049

Alan Herbert

引用次数: 0

Tribological metamaterial: how feathers reduce drag and friction through hidden energy dissipation structures.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0751

Qingrui Song, Tianci Chen, Wei Sun, Mingjian Huang, Yuhang Guo, Yunlong Jiao, Kun Liu, Jiaxin Ye

{"title":"Tribological metamaterial: how feathers reduce drag and friction through hidden energy dissipation structures.","authors":"Qingrui Song, Tianci Chen, Wei Sun, Mingjian Huang, Yuhang Guo, Yunlong Jiao, Kun Liu, Jiaxin Ye","doi":"10.1098/rsif.2024.0751","DOIUrl":"10.1098/rsif.2024.0751","url":null,"abstract":"The lateral moving resistance of a liquid droplet on a solid surface generally increases with velocity and is dominated by the non-viscous wetting line friction. Many superhydrophobic man-made and biological surfaces have minimal, nevertheless speed-sensitive, water droplet friction, limiting their potential to reduce drag at high speeds in natural situations. Using an in situ surface force apparatus, we demonstrated low and remarkably speed-insensitive (over 300-fold) water bridge sliding friction on a goose feather vane. Detailed analyses suggest a dominant, hidden energy dissipation channel probably related to the deformation and elastic recovery of feather's characteristic metamaterial-like structure, which also results in feather's speed insensitive (from 0.1 to 1 mm s-1) ultra-low dry sliding friction coefficient observed in this study (approx. 0.07). The new insights gained have the potential to motivate novel approaches to the design of all-weather and speed-insensitive low-friction surfaces with practical applications in aviation and lubrication technology.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240751"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficiency and control trade-offs and work loop characteristics of flapping-wing systems with synchronous and asynchronous muscles.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsif.2024.0660

Suyash Agrawal, Christopher Rahn, Bo Cheng

{"title":"Efficiency and control trade-offs and work loop characteristics of flapping-wing systems with synchronous and asynchronous muscles.","authors":"Suyash Agrawal, Christopher Rahn, Bo Cheng","doi":"10.1098/rsif.2024.0660","DOIUrl":"10.1098/rsif.2024.0660","url":null,"abstract":"Natural fliers with flapping wings face the dual challenges of energy efficiency and active control of wing motion for achieving diverse modes of flight. It is hypothesized that flapping-wing systems use resonance to improve muscle mechanical output energy efficiency, a principle often followed in bioinspired flapping-wing robots. However, resonance can limit the degree of active control, a trade-off rooted in the dynamics of wing motor systems and can be potentially reflected in muscle work loops. To systematically investigate how energy efficiency trades off with active control of wingbeat frequency and amplitude, here we developed a parsimonious model of the wing motor system with either synchronous or asynchronous power muscles. We then non-dimensionalized the model and performed simulations to examine model characteristics as functions of Weis-Fogh number and dimensionless flapping frequency. For synchronous power muscles, our model predicts that energy efficiency trades off with frequency control rather than amplitude control at high Weis-Fogh numbers; however, no such trade-off was found for models with asynchronous power muscles. The work loops alone are insufficient to fully capture wing motor characteristics, and therefore fail to directly reflect the trade-offs. Finally, using simulation results, we predict that natural fliers function at Weis-Fogh numbers close to 1.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240660"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0635

Humeyra Betul Yekeler, Ilke Kabaoglu, Ece Guler, Manuel Pedro F Graça, Oguzhan Gunduz, Deepak M Kalaskar, Muhammet Emin Cam

{"title":"A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.","authors":"Humeyra Betul Yekeler, Ilke Kabaoglu, Ece Guler, Manuel Pedro F Graça, Oguzhan Gunduz, Deepak M Kalaskar, Muhammet Emin Cam","doi":"10.1098/rsif.2024.0635","DOIUrl":"10.1098/rsif.2024.0635","url":null,"abstract":"Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid and polycaprolactone, resulting in the fabrication of drug-loaded fibrous patches (DFPs) for transdermal application, both by electrospinning (ES) and by pressurized gyration (PG). Scanning electron microscopy results revealed that DFPs generated through the PG method exhibited smaller diameters and a larger surface area than ES. Fourier-transform infrared spectroscopy and X-ray powder diffraction analyses confirmed the successful encapsulation of the drug in both DFPs. DFPs/PG exhibited a controlled release of 98.7 ± 1.3% of the total drug over 14 days, while DFPs/ES released 98.1 ± 2.1% in 12 days, according to in vitro drug release studies. This study underscores that the PG method can generate DFPs with extended controlled release. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide test results validate the biocompatibility of DFPs, affirming their lack of adverse effects on human dermal fibroblast cell viability. Consequently, DFPs can be manufactured for transdermal administration using PG, exhibiting similar characteristics to ES but with the added advantage of mass production capability.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240635"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Less is more: slow-codon windows enhance eGFP mRNA resilience against RNA interference.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsif.2024.0582

Judith A Müller, Gerlinde Schwake, Anita Reiser, Daniel Woschée, Zahra Alirezaeizanjani, Joachim O Rädler, Sophia Rudorf

{"title":"Less is more: slow-codon windows enhance eGFP mRNA resilience against RNA interference.","authors":"Judith A Müller, Gerlinde Schwake, Anita Reiser, Daniel Woschée, Zahra Alirezaeizanjani, Joachim O Rädler, Sophia Rudorf","doi":"10.1098/rsif.2024.0582","DOIUrl":"10.1098/rsif.2024.0582","url":null,"abstract":"Extensive efforts have been devoted to enhancing the translation efficiency of mRNA delivered to mammalian cells via codon optimization. However, the impact of codon choice on mRNA stability remains underexplored. In this study, we investigated the influence of codon usage on mRNA degradation kinetics in cultured human cell lines using live-cell imaging on single-cell arrays. By measuring mRNA lifetimes at the single-cell level for synthetic mRNA constructs, we confirmed that mRNAs containing slowly translated codon windows have shorter lifetimes. Unexpectedly, these mRNAs did not exhibit decreased stability in the presence of small interfering RNA (siRNA) compared with the unmutated sequence, suggesting an interference of different concurrent degradation mechanisms. We employed stochastic simulations to predict ribosome density along the open reading frame, revealing that the ribosome densities correlated with mRNA stability in a cell-type- and codon-position-specific manner. In summary, our results suggest that the effect of codon choice and its influence on mRNA lifetime is context-dependent with respect to cell type, codon position and RNA interference.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240582"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing transmission in multiple settings is required to eliminate the risk of major Ebola outbreaks: a mathematical modelling study.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsif.2024.0765

Abbie Evans, William Hart, Stefano Longobardi, Rajat Desikan, Anna Sher, Robin Thompson

{"title":"Reducing transmission in multiple settings is required to eliminate the risk of major Ebola outbreaks: a mathematical modelling study.","authors":"Abbie Evans, William Hart, Stefano Longobardi, Rajat Desikan, Anna Sher, Robin Thompson","doi":"10.1098/rsif.2024.0765","DOIUrl":"10.1098/rsif.2024.0765","url":null,"abstract":"The Ebola virus (EV) persists in animal populations, with zoonotic transmission to humans occurring every few months or years. When zoonotic transmission arises, it is important to understand which interventions are most effective at preventing a major outbreak driven by human-to-human transmission. Here, we analyse a mathematical model of EV transmission and calculate the probability of a major outbreak starting from a single introduced case. We consider community, funeral and healthcare facility transmission and conduct sensitivity analyses to explore the effects of non-pharmaceutical interventions (NPIs) that influence these transmission routes. We find that, if the index case is treated in the community, then the elimination of transmission at funerals reduces the probability of a major outbreak substantially (from 0.410 to 0.066 under our baseline model parametrization). However, eliminating the risk of major outbreaks entirely requires combinations of measures that limit transmission in different settings, such as community engagement to promote safe burial practices and implementation of barrier nursing in healthcare facilities. In addition to generating insights into the drivers of Ebola outbreaks, this research provides a modelling framework for assessing the effectiveness of interventions at mitigating outbreaks of other infectious diseases with transmission in multiple settings.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240765"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of layered architecture in marine sponge root fibres: new lessons from nature for the design of tension cables.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsif.2024.0252

Sayaka Kochiyama, Haneesh Kesari

引用次数: 0