Journal of The Royal Society Interface最新文献

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Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans. 引入人体H5N1流感感染宿主内动态和突变建模框架。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1098/rsif.2024.0910
Daniel Higgins, Joshua Looker, Robert Sunnucks, Jonathan Carruthers, Thomas Finnie, Matt J Keeling, Edward M Hill
{"title":"Introducing a framework for within-host dynamics and mutations modelling of H5N1 influenza infection in humans.","authors":"Daniel Higgins, Joshua Looker, Robert Sunnucks, Jonathan Carruthers, Thomas Finnie, Matt J Keeling, Edward M Hill","doi":"10.1098/rsif.2024.0910","DOIUrl":"10.1098/rsif.2024.0910","url":null,"abstract":"<p><p>Avian influenza A(H5N1) poses a public health risk due to its pandemic potential should the virus mutate to become human-to-human transmissible. To date, reported influenza A(H5N1) human cases have typically occurred in the lower respiratory tract with a high case fatality rate. There is prior evidence of some influenza A(H5N1) strains being a small number of amino acid mutations away from achieving droplet transmissibility, possibly allowing them to be spread between humans. We present a mechanistic within-host influenza A(H5N1) infection model, novel for its explicit consideration of the biological differences between the upper and lower respiratory tracts. We then estimate a distribution of viral lifespans and effective replication rates in human H5N1 influenza cases. By combining our within-host model with a viral mutation model, we determine the probability of an infected individual generating a droplet transmissible strain of influenza A(H5N1) through mutation. For three mutations, we found a peak probability of approximately [Formula: see text] that a human case of H5N1 influenza produces at least one virion during the infectious period. Our findings provide insights into the risk of differing infectious pathways of influenza A(H5N1) (namely avian-human versus avian-mammal-human routes), demonstrating the three-mutation pathway being a cause of concern in human cases.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 228","pages":"20240910"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212982/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel experimental methods to investigate the effects of plant phytoliths on tooth enamel wear. 植物植物岩对牙釉质磨损影响的新实验研究。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1098/rsif.2025.0175
Yassmin Lakhal, Javier Redolat, Estíbaliz Sánchez-González, Paul J Constantino, Michael A Berthaume, Óscar Borrero-López, Elena Pinilla-Cienfuegos
{"title":"Novel experimental methods to investigate the effects of plant phytoliths on tooth enamel wear.","authors":"Yassmin Lakhal, Javier Redolat, Estíbaliz Sánchez-González, Paul J Constantino, Michael A Berthaume, Óscar Borrero-López, Elena Pinilla-Cienfuegos","doi":"10.1098/rsif.2025.0175","DOIUrl":"10.1098/rsif.2025.0175","url":null,"abstract":"<p><p>Dental enamel is one of the strongest biomaterials found in nature, making its mechanical failure of significant interest to the biomaterials and dental communities. Recent studies on the mechanisms of enamel wear have yielded conflicting results, highlighting the need for more realistic experimental approaches. Here, we introduce a novel experimental methodology based on nanotechnology techniques and micromechanical/materials testing to simulate and characterize, for the first time, <i>in vitro</i> microwear caused by the sliding of artificial models of soft leaves containing phytolith particles against human dental enamel. While embedded phytoliths undergo mechanical degradation upon cyclic contacts, they increase the extent of pre-existing wear in enamel and decrease its mineral content. Surprisingly, the primary wear mechanism of enamel is 'quasi-plastic' (i.e. permanent) deformation enabled by failure of weak interphases, dominated at the microstructural scale. Mechanisms responsible for material removal in enamel at different length scales are identified and discussed. This research offers new insights into enamel failure that can further reveal information about an animal's biology, behaviour, biomechanics and ecology, offering an interdisciplinary approach to the interface between the physical and life sciences.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 228","pages":"20250175"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Personalizing computational models to construct medical digital twins. 个性化计算模型构建医学数字双胞胎。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1098/rsif.2025.0055
Adam Knapp, Daniel A Cruz, Borna Mehrad, Reinhard C Laubenbacher
{"title":"Personalizing computational models to construct medical digital twins.","authors":"Adam Knapp, Daniel A Cruz, Borna Mehrad, Reinhard C Laubenbacher","doi":"10.1098/rsif.2025.0055","DOIUrl":"10.1098/rsif.2025.0055","url":null,"abstract":"<p><p>Digital twin technology, originally developed for engineering, is being adapted to biomedicine and healthcare. A key challenge in this process is dynamically calibrating computational models to individual patients using data collected over time. This calibration is vital for improving model-based predictions and enabling personalized medicine. Biomedical models are often complex, incorporating multiple scales of biology and both stochastic and spatially heterogeneous elements. Agent-based models, which simulate autonomous agents, such as cells, are commonly used to capture how local interactions affect system-level behaviour. However, no standard personalization methods exist for these models. The main challenge is bridging the gap between clinically measurable macrostates (e.g. blood pressure and heart rate) and the detailed microstate data (e.g. cellular processes) needed to run the model. In this article, we propose an algorithm that applies the ensemble Kalman filter, a classic data-assimilation technique, at the macrostate level. We then link the Kalman update at the macrostate to corresponding updates at the microstate level, ensuring that the resulting microstates are compatible with the desired macrostates and consistent with the model's dynamics. This approach improves the personalization of complex biomedical models and enhances model-based forecasts for individual patients.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 228","pages":"20250055"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages of using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases. 在传染病和非传染病的预防和治疗性疫苗战略中使用补体成分的优势。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1098/rsif.2025.0138
Nur Hendri Wahyu Firdaus, Buddhadev Mallick, Kutty Selva Nandakumar, Akhilesh Kumar Shakya
{"title":"Advantages of using complement components in preventive and therapeutic vaccine strategies for infectious and non-infectious diseases.","authors":"Nur Hendri Wahyu Firdaus, Buddhadev Mallick, Kutty Selva Nandakumar, Akhilesh Kumar Shakya","doi":"10.1098/rsif.2025.0138","DOIUrl":"10.1098/rsif.2025.0138","url":null,"abstract":"<p><p>The complement system, a vital component of innate immunity, is indispensable to our immune defence mechanisms against microbial infections. Acting as a surveillance mechanism, it identifies and eliminates pathogens by activating several complement components and associated signalling pathways, which are also implicated in various diseases and disorders. Beyond its defensive role, the complement system has emerged as a promising target for vaccine development in therapeutic and preventive regimens, offering new vaccine strategies to combat non-infectious and infectious diseases. Activation of the complement pathways by various natural and synthetic adjuvants enhances protective immune responses, highlighting its utility in vaccine design. This approach could be useful for targeting autoimmune diseases, infectious diseases, cancer and neurological disorders.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 228","pages":"20250138"},"PeriodicalIF":3.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12212990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metachronal rowing provides robust propulsive performance across four orders of magnitude variation in Reynolds number. 在雷诺数的四个数量级变化中,超时空划船提供了强大的推进性能。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.1098/rsif.2024.0822
Mitchell P Ford, Arvind Santhanakrishnan
{"title":"Metachronal rowing provides robust propulsive performance across four orders of magnitude variation in Reynolds number.","authors":"Mitchell P Ford, Arvind Santhanakrishnan","doi":"10.1098/rsif.2024.0822","DOIUrl":"10.1098/rsif.2024.0822","url":null,"abstract":"<p><p>Metachronal rowing of multiple appendages is a swimming strategy used by numerous organisms across various taxa, with body sizes ranging of the orders of [Formula: see text] to [Formula: see text] m. This corresponds to a huge variation in fluid flow regimes, characterized by paddle-scale Reynolds numbers ([Formula: see text]) ranging from the orders of [Formula: see text] (viscosity dominated) to [Formula: see text] (inertially dominated). Though the rhythmic stroking of the paddles is conserved across species and developmental stages, the hydrodynamic scalability of metachronal rowing has not been examined across this broad [Formula: see text] range. Using a self-propelled metachronal paddling robot, we examine swimming performance changes across four orders of magnitude variation in [Formula: see text] most relevant to crustaceans ([Formula: see text] to [Formula: see text]). We found that wake Strouhal number ([Formula: see text]), which characterizes momentum transfer from paddles to the wake, was unchanged for [Formula: see text] ([Formula: see text]). This is within the reported range of Strouhal numbers of various flying and swimming animals. Peak dimensionless circulation of paddle tip vortices increased linearly with stroke kinematics but was mostly unaffected by fluid viscosity. These findings show that the swimming performance of metachronal rowing is conserved across widely varying flow regimes, with dimensionless swimming speed scaling linearly with [Formula: see text] across the entire tested range.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240822"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rethinking planetary protection: an island biogeographical analysis. 重新思考行星保护:一个岛屿生物地理学分析。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2025.0079
Daniel J Brener, Charles S Cockell
{"title":"Rethinking planetary protection: an island biogeographical analysis.","authors":"Daniel J Brener, Charles S Cockell","doi":"10.1098/rsif.2025.0079","DOIUrl":"10.1098/rsif.2025.0079","url":null,"abstract":"<p><p>We reconsider the problem of planetary protection using, by the analogy of planets as islands, the theory of island biogeography. We show that although the notion of equilibrium populations that emerge from the effects of immigration and extinction generally breaks down when applied to interplanetary scales, the mean-time to extinction resulting from the combined effects of growth and death rates can be quantified. We reconsider the probabilistic model of planetary protection, discuss how mean-time to extinction can instead be used to assess contamination risk, and we propose a research direction for planetary protection based on these ideas. We discuss more broadly the applicability of island biogeography to considering biotic transfer at interplanetary scales.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250079"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender differences in resume language and gender gaps in salary expectations. 简历语言的性别差异和薪资期望的性别差异。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.1098/rsif.2024.0784
Qian Qu, Quan-Hui Liu, Jian Gao, Shudong Huang, Wentao Feng, Zhongtao Yue, Xin Lu, Tao Zhou, Jiancheng Lv
{"title":"Gender differences in resume language and gender gaps in salary expectations.","authors":"Qian Qu, Quan-Hui Liu, Jian Gao, Shudong Huang, Wentao Feng, Zhongtao Yue, Xin Lu, Tao Zhou, Jiancheng Lv","doi":"10.1098/rsif.2024.0784","DOIUrl":"10.1098/rsif.2024.0784","url":null,"abstract":"<p><p>How men and women present themselves in their resumes may affect their opportunity in job seeking. To investigate gender differences in resume writing and how they are associated with gender gaps in the labour market, we analysed 6.9 million resumes of Chinese job applicants in this study. Results reveal substantial gender resume differences, where women and men show distinct patterns in both simple language features and high-level semantic structures in the word embedding space of resumes. In particular, women tend to use shorter resumes, longer sentences and a more diverse set of unique words. Neural network models trained on resumes can predict gender with 80% accuracy, and the accuracy decreases with education levels and text standardization requirements. Moreover, while better language skills are associated with higher salary expectations, this positive relationship is magnified for men but weakened for women in women-dominated occupations. This study presents a new venue for the understanding of gender differences and provides empirical findings on how men and women are different in self-portraying and job seeking.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240784"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advantages of run-reverse motility pattern of bacteria for tracking light and small food sources in dynamic fluid environments. 细菌的顺反运动模式在动态流体环境中追踪光和小食物源的优势。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1098/rsif.2025.0037
Ksenia Guseva, Ulrike Feudel
{"title":"Advantages of run-reverse motility pattern of bacteria for tracking light and small food sources in dynamic fluid environments.","authors":"Ksenia Guseva, Ulrike Feudel","doi":"10.1098/rsif.2025.0037","DOIUrl":"10.1098/rsif.2025.0037","url":null,"abstract":"<p><p>Marine bacteria are fundamental to the processes and cycles that sustain ocean ecosystems. Their activity at small scales, where they search for food sources in a highly heterogeneous and dynamic environment, for example controls the decomposition of organic matter. To be effective, these microorganisms have evolved sophisticated behaviours, which include extremely rapid swimming speeds, a precise chemosensing ability and particular swimming patterns. One of these peculiar motility patterns often recorded in the ocean is run-reverse (Mitchell <i>et al</i> 1996 Clustering of marine bacteria in seawater enrichments. <i>Appl. Environ. Microbiol.</i> <b>62</b>, 3716-3721. (doi:10.1128/aem.62.10.3716-3721.1996), Stocker R. 2011 Reverse and flick: hybrid locomotion in bacteria. <i>Proc. Natl Acad. Sci. USA</i> <b>108</b>, 2635-2636. (doi:10.1073/pnas.1019199108), where bacteria alternate between forward (pushing) and backwards (pulling) swimming modes. In this study, we investigate whether this swimming pattern offers advantages to microorganisms that actively track small and light food sources carried by a dynamic flow. For that we develop an individual-based model, where elongated self-propelled particles (microswimmers) track passive food particles (tracers) in a random kinematic flow field, also known as synthetic turbulent flow. We compare the widely studied motility pattern of run-and-tumble with the run-reverse mode used by marine bacteria. Our results reveal a significant hydrodynamic advantage of the run-reverse motility pattern of bacteria combined with their elongated shapes for efficiently tracking light food sources in dynamic fluid environments.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250037"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drivers of cooperation in social dilemmas on higher-order networks. 高阶网络社会困境中的合作驱动因素。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1098/rsif.2025.0134
Onkar Sadekar, Andrea Civilini, Vito Latora, Federico Battiston
{"title":"Drivers of cooperation in social dilemmas on higher-order networks.","authors":"Onkar Sadekar, Andrea Civilini, Vito Latora, Federico Battiston","doi":"10.1098/rsif.2025.0134","DOIUrl":"10.1098/rsif.2025.0134","url":null,"abstract":"<p><p>Understanding cooperation in social dilemmas requires models that capture the complexity of real-world interactions. While network frameworks have provided valuable insights to model the evolution of cooperation, they are unable to encode group interactions properly. Here, we introduce a general higher-order networks framework for multi-player games on structured populations. Our model considers multi-dimensional strategies, based on the observation that social behaviours are affected by the size of the group interaction. We investigate the dynamical and structural coupling between different orders of interactions, revealing the crucial role of nested multi-level interactions and showing how such features can enhance cooperation beyond the limit of traditional models with uni-dimensional strategies. Our work identifies the key drivers promoting cooperative behaviour commonly observed in real-world group social dilemmas.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250134"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network. 对基因调控网络动态的转录爆发效应的有效近似。
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2025.0170
Jochen Kursawe, Antoine Moneyron, Tobias Galla
{"title":"Efficient approximations of transcriptional bursting effects on the dynamics of a gene regulatory network.","authors":"Jochen Kursawe, Antoine Moneyron, Tobias Galla","doi":"10.1098/rsif.2025.0170","DOIUrl":"10.1098/rsif.2025.0170","url":null,"abstract":"<p><p>Mathematical models of gene regulatory networks are widely used to study cell fate changes and transcriptional regulation. When designing such models, it is important to accurately account for sources of stochasticity. However, doing so can be computationally expensive and analytically untractable, posing limits on the extent of our explorations and on parameter inference. Here, we explore this challenge using the example of a simple auto-negative feedback motif, in which we incorporate stochastic variation due to transcriptional bursting and noise from finite copy numbers. We find that transcriptional bursting may change the qualitative dynamics of the system by inducing oscillations when they would not otherwise be present, or by magnifying existing oscillations. We describe multiple levels of approximation for the model in the form of differential equations, piecewise-deterministic processes and stochastic differential equations. Importantly, we derive how the classical chemical Langevin equation can be extended to include a noise term representing transcriptional bursting. This approximation drastically decreases computation times and allows us to analytically calculate properties of the dynamics, such as their power spectrum. We explore when these approximations break down and provide recommendations for their use. Our analysis illustrates the importance of accounting for transcriptional bursting when simulating gene regulatory network dynamics and provides recommendations to do so with computationally efficient methods.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250170"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187408/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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