Journal of The Royal Society Interface最新文献

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Indirect reciprocity in the public goods game with collective reputations.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1098/rsif.2024.0827
Ming Wei, Xin Wang, Longzhao Liu, Hongwei Zheng, Yishen Jiang, Yajing Hao, Zhiming Zheng, Feng Fu, Shaoting Tang
{"title":"Indirect reciprocity in the public goods game with collective reputations.","authors":"Ming Wei, Xin Wang, Longzhao Liu, Hongwei Zheng, Yishen Jiang, Yajing Hao, Zhiming Zheng, Feng Fu, Shaoting Tang","doi":"10.1098/rsif.2024.0827","DOIUrl":"https://doi.org/10.1098/rsif.2024.0827","url":null,"abstract":"<p><p>Indirect reciprocity unveils how social cooperation is founded upon moral systems. Within the frame of dyadic games based on individual reputations, the 'leading-eight' strategies distinguish themselves in promoting and sustaining cooperation. However, in real-world societies, there are widespread interactions at the group level, where individuals need to make a singular action choice when facing multiple individuals with different reputations. Here, through introducing the assessment of collective reputations, we develop a framework that embeds group-level reputation structure into public goods games to study the evolution of group-level indirect reciprocity. We show that changing the criteria of group assessment destabilizes the reputation dynamics of leading-eight strategies. In a particular range of social assessment criteria, all leading-eight strategies can break the social dilemma in public goods games and sustain cooperation. Specifically, there exists an optimal, moderately set assessment criterion that is most conducive to promoting cooperation. Moreover, in the evolution of assessment criteria, the preference of the leading-eight strategies for social strictness is inversely correlated with the payoff level. Our work reveals the impact of social strictness on prosocial behaviour, highlighting the importance of group-level interactions in the analysis of evolutionary games and complex social dynamics.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 225","pages":"20240827"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1098/rsif.2024.0675
Bjarke Frost Nielsen, Chadi M Saad-Roy, C Jessica E Metcalf, Cécile Viboud, Bryan T Grenfell
{"title":"Eco-evolutionary dynamics of pathogen immune-escape: deriving a population-level phylodynamic curve.","authors":"Bjarke Frost Nielsen, Chadi M Saad-Roy, C Jessica E Metcalf, Cécile Viboud, Bryan T Grenfell","doi":"10.1098/rsif.2024.0675","DOIUrl":"https://doi.org/10.1098/rsif.2024.0675","url":null,"abstract":"<p><p>The phylodynamic curve (Grenfell <i>et al</i>. 2004 <i>Science</i> <b>303</b>, 327-332 (doi:10.1126/science.1090727)) conceptualizes how immunity shapes the rate of viral adaptation in a non-monotonic fashion, through its opposing effects on viral abundance and the strength of selection. However, concrete and quantitative model realizations of this influential concept are rare. Here, we present an analytic, stochastic framework in which a population-scale phylodynamic curve emerges dynamically, allowing us to address questions regarding the risk and timing of the emergence of viral immune escape variants. We explore how pathogen- and population-specific parameters such as strength of immunity, transmissibility, seasonality and antigenic constraints affect the emergence risk. For pathogens exhibiting pronounced seasonality, we find that the timing of likely immune-escape variant emergence depends on the level of case importation between regions. Motivated by the COVID-19 pandemic, we probe the likely effects of non-pharmaceutical interventions (NPIs), and the lifting thereof, on the risk of viral escape variant emergence. Looking ahead, the framework has the potential to become a useful tool for probing how natural immunity, as well as choices in vaccine design and distribution and the implementation of NPIs, affect the evolution of common viral pathogens.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 225","pages":"20240675"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the secrets of scenic beauty: a quantitative analysis of object variety and connections in scenic images.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1098/rsif.2025.0045
Junjun Yin, Guangqing Chi, Bin Jiang
{"title":"Unlocking the secrets of scenic beauty: a quantitative analysis of object variety and connections in scenic images.","authors":"Junjun Yin, Guangqing Chi, Bin Jiang","doi":"10.1098/rsif.2025.0045","DOIUrl":"https://doi.org/10.1098/rsif.2025.0045","url":null,"abstract":"<p><p>The perception of beauty, though often subjective, is influenced by identifiable structural and spatial patterns that shape how individuals experience their surroundings. This study explores the roles of object variety and connections in scenic images in shaping perceptions of environmental aesthetics, using advanced computer vision techniques and regression analysis. Drawing on data from the Scenic-Or-Not project and leveraging the Segment Anything Model, we analysed landscape photographs to understand how object diversity and spatial arrangement affect aesthetic judgments. Our findings reveal a positive correlation between object diversity and perceived scenicness, emphasizing the importance of visual richness and complexity in enhancing scenic appeal. However, excessive object diversity can introduce visual clutter and diminish aesthetic value. Our analysis of object connections, measured through graph-based metrics like network density and clustering coefficient, reveals that denser and more interconnected arrangements enhance scenic appeal, while overly efficient local connections reduce visual interest. These results demonstrate the importance of balancing complexity, coherence and interconnectedness in scenic design. By situating these findings within established theoretical frameworks, this study provides insights for disciplines such as environmental science, urban planning and landscape management, offering guidance for creating environments that evoke positive aesthetic experiences while maintaining visual harmony and interest.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 225","pages":"20250045"},"PeriodicalIF":3.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A predictive surrogate model of blood haemodynamics for patient-specific carotid artery stenosis.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsif.2024.0774
Mostafa Barzegar Gerdroodbary, Sajad Salavatidezfouli
{"title":"A predictive surrogate model of blood haemodynamics for patient-specific carotid artery stenosis.","authors":"Mostafa Barzegar Gerdroodbary, Sajad Salavatidezfouli","doi":"10.1098/rsif.2024.0774","DOIUrl":"10.1098/rsif.2024.0774","url":null,"abstract":"<p><p>In this study, the haemodynamic factors inside the patient-specific carotid artery with stenosis are evaluated via a predictive surrogate model. The technique of proper orthogonal decomposition (POD) is used for reducing the order of the main model and consequently, the long short-term memory is employed for the prediction of main blood flow parameters, i.e. blood velocity and pressure along the patient-specific carotid artery with stenosis. The efficiency of the proposed machine learning technique has been evaluated in patient-specific carotid arteries with/without stenosis. Besides, the reconstruction error analysis is performed for different POD mode numbers. Our results demonstrate that the value of blood velocity at different stages of the cardiac cycle has a great impact on the efficiency of the proposed method for the estimation of blood haemodynamics. The presence of stenosis inside the patient-specific carotid artery intensifies the complexity of the blood flow, and consequently, the magnitude of the errors for the prediction is increased when the stenosis exists in the patient-specific carotid artery.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240774"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of trust in the N-player trust game with transformation incentive mechanism.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI: 10.1098/rsif.2024.0726
Yuyuan Liu, Lichen Wang, Ruqiang Guo, Shijia Hua, Linjie Liu, Liang Zhang, The Anh Han
{"title":"Evolution of trust in the <i>N</i>-player trust game with transformation incentive mechanism.","authors":"Yuyuan Liu, Lichen Wang, Ruqiang Guo, Shijia Hua, Linjie Liu, Liang Zhang, The Anh Han","doi":"10.1098/rsif.2024.0726","DOIUrl":"10.1098/rsif.2024.0726","url":null,"abstract":"<p><p>Trust game is commonly used to study the evolution of trust among unrelated individuals. It offers valuable insights into human interactions in a range of disciplines, including economics, sociology and psychology. Previous research has revealed that reward and punishment systems can effectively promote the evolution of trust. However, these investigations overlook the gaming environment, leaving unresolved the optimal conditions for employing distinct incentives to effectively facilitate trust level. To bridge this gap, we introduce a transformation incentive mechanism in an <i>N</i>-player trust game, where trustees are given different forms of incentives depending on the number of trustees in the group. Using the Markov decision process approach, our research shows that as incentives increase, the level of trust rises continuously, eventually reaching a high level of coexistence between investors and trustworthy trustees. Specifically, in the case of smaller incentives, rewarding trustworthy trustees is more effective. Conversely, in the case of larger incentives, punishing untrustworthy trustees is more effective. Additionally, we find that moderate incentives have a positive impact on increasing the average payoff within the group.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240726"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0860
Tom White, Arístides López-Márquez, Carmen Badosa, Ceclila Jimenez-Mallebrera, Josep Samitier, Marina Inés Giannotti, Anna Lagunas
{"title":"Nanomechanics of cell-derived matrices as a functional read-out in collagen VI-related congenital muscular dystrophies.","authors":"Tom White, Arístides López-Márquez, Carmen Badosa, Ceclila Jimenez-Mallebrera, Josep Samitier, Marina Inés Giannotti, Anna Lagunas","doi":"10.1098/rsif.2024.0860","DOIUrl":"10.1098/rsif.2024.0860","url":null,"abstract":"<p><p>Changes in the mechanical properties of the extracellular matrix (ECM) are a hallmark of disease. Due to its relevance, several <i>in vitro</i> models have been developed for the ECM, including cell-derived matrices (CDMs). CDMs are decellularized natural ECMs assembled by cells that closely mimic the <i>in vivo</i> stromal fibre organization and molecular content. Here, we applied atomic force microscopy-force spectroscopy (AFM-FS) to evaluate the nanomechanical properties of CDMs obtained from patients diagnosed with collagen VI-related congenital muscular dystrophies (COL6-RDs). COL6-RDs are a set of neuromuscular conditions caused by pathogenic variants in any of the three major COL6 genes, which result in deficiency or dysfunction of the COL6 incorporated into the ECM of connective tissues. Current diagnosis includes the genetic confirmation of the disease and categorization of the phenotype based on maximum motor ability, as no direct correlation exists between genotype and phenotype of COL6-RDs. We describe differences in the elastic modulus (<i>E</i>) among CDMs from patients with different clinical phenotypes, as well as the restoration of <i>E</i> in CDMs obtained from genetically edited cells. Results anticipate the potential of the nanomechanical analysis of CDMs as a complementary clinical tool, providing phenotypic information about COL6-RDs and their response to gene therapies.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240860"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Flipons enable genomes to learn by intermediating the exchange of energy for information.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-26 DOI: 10.1098/rsif.2025.0049
Alan Herbert
{"title":"Flipons enable genomes to learn by intermediating the exchange of energy for information.","authors":"Alan Herbert","doi":"10.1098/rsif.2025.0049","DOIUrl":"10.1098/rsif.2025.0049","url":null,"abstract":"<p><p>Recent findings have confirmed the long-held belief that alternative DNA conformations encoded by genetic elements called flipons have important biological roles. Many of these alternative structures are formed by sequences originally spread throughout the human genome by endogenous retroelements (ERE) that captured 50% of the territory before being disarmed. Only 2.6% of the remaining DNA codes for proteins. Other organisms have instead streamlined their genomes by eliminating invasive retroelements and other repeat elements. The question arises, why retain any ERE at all? A new synthesis suggests that flipons enable genomes to learn and programme the context-specific readout of information by altering the transcripts produced. The exchange of energy for information is mediated through changes in DNA topology. Here I provide a formulation for how genomes learn and describe the underlying p-bit algorithm through which flipons are tuned. The framework suggests new strategies for the therapeutic reprogramming of cells.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20250049"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tribological metamaterial: how feathers reduce drag and friction through hidden energy dissipation structures.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0751
Qingrui Song, Tianci Chen, Wei Sun, Mingjian Huang, Yuhang Guo, Yunlong Jiao, Kun Liu, Jiaxin Ye
{"title":"Tribological metamaterial: how feathers reduce drag and friction through hidden energy dissipation structures.","authors":"Qingrui Song, Tianci Chen, Wei Sun, Mingjian Huang, Yuhang Guo, Yunlong Jiao, Kun Liu, Jiaxin Ye","doi":"10.1098/rsif.2024.0751","DOIUrl":"10.1098/rsif.2024.0751","url":null,"abstract":"<p><p>The lateral moving resistance of a liquid droplet on a solid surface generally increases with velocity and is dominated by the non-viscous wetting line friction. Many superhydrophobic man-made and biological surfaces have minimal, nevertheless speed-sensitive, water droplet friction, limiting their potential to reduce drag at high speeds in natural situations. Using an <i>in situ</i> surface force apparatus, we demonstrated low and remarkably speed-insensitive (over 300-fold) water bridge sliding friction on a goose feather vane. Detailed analyses suggest a dominant, hidden energy dissipation channel probably related to the deformation and elastic recovery of feather's characteristic metamaterial-like structure, which also results in feather's speed insensitive (from 0.1 to 1 mm s<sup>-1</sup>) ultra-low dry sliding friction coefficient observed in this study (approx. 0.07). The new insights gained have the potential to motivate novel approaches to the design of all-weather and speed-insensitive low-friction surfaces with practical applications in aviation and lubrication technology.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240751"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficiency and control trade-offs and work loop characteristics of flapping-wing systems with synchronous and asynchronous muscles.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-19 DOI: 10.1098/rsif.2024.0660
Suyash Agrawal, Christopher Rahn, Bo Cheng
{"title":"Efficiency and control trade-offs and work loop characteristics of flapping-wing systems with synchronous and asynchronous muscles.","authors":"Suyash Agrawal, Christopher Rahn, Bo Cheng","doi":"10.1098/rsif.2024.0660","DOIUrl":"10.1098/rsif.2024.0660","url":null,"abstract":"<p><p>Natural fliers with flapping wings face the dual challenges of energy efficiency and active control of wing motion for achieving diverse modes of flight. It is hypothesized that flapping-wing systems use resonance to improve muscle mechanical output energy efficiency, a principle often followed in bioinspired flapping-wing robots. However, resonance can limit the degree of active control, a trade-off rooted in the dynamics of wing motor systems and can be potentially reflected in muscle work loops. To systematically investigate how energy efficiency trades off with active control of wingbeat frequency and amplitude, here we developed a parsimonious model of the wing motor system with either synchronous or asynchronous power muscles. We then non-dimensionalized the model and performed simulations to examine model characteristics as functions of Weis-Fogh number and dimensionless flapping frequency. For synchronous power muscles, our model predicts that energy efficiency trades off with frequency control rather than amplitude control at high Weis-Fogh numbers; however, no such trade-off was found for models with asynchronous power muscles. The work loops alone are insufficient to fully capture wing motor characteristics, and therefore fail to directly reflect the trade-offs. Finally, using simulation results, we predict that natural fliers function at Weis-Fogh numbers close to 1.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240660"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143657545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.
IF 3.7 2区 综合性期刊
Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-12 DOI: 10.1098/rsif.2024.0635
Humeyra Betul Yekeler, Ilke Kabaoglu, Ece Guler, Manuel Pedro F Graça, Oguzhan Gunduz, Deepak M Kalaskar, Muhammet Emin Cam
{"title":"A comparison of electrospinning and pressurized gyration: Production of empagliflozin-loaded polylactic acid/polycaprolactone fibrous patches.","authors":"Humeyra Betul Yekeler, Ilke Kabaoglu, Ece Guler, Manuel Pedro F Graça, Oguzhan Gunduz, Deepak M Kalaskar, Muhammet Emin Cam","doi":"10.1098/rsif.2024.0635","DOIUrl":"10.1098/rsif.2024.0635","url":null,"abstract":"<p><p>Novel therapeutic strategies are essential for enhancing efficacy and accelerating the treatment of diabetes mellitus. This investigation focused on incorporating empagliflozin into a composite of polylactic acid and polycaprolactone, resulting in the fabrication of drug-loaded fibrous patches (DFPs) for transdermal application, both by electrospinning (ES) and by pressurized gyration (PG). Scanning electron microscopy results revealed that DFPs generated through the PG method exhibited smaller diameters and a larger surface area than ES. Fourier-transform infrared spectroscopy and X-ray powder diffraction analyses confirmed the successful encapsulation of the drug in both DFPs. DFPs/PG exhibited a controlled release of 98.7 ± 1.3% of the total drug over 14 days, while DFPs/ES released 98.1 ± 2.1% in 12 days, according to <i>in vitro</i> drug release studies. This study underscores that the PG method can generate DFPs with extended controlled release. 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide test results validate the biocompatibility of DFPs, affirming their lack of adverse effects on human dermal fibroblast cell viability. Consequently, DFPs can be manufactured for transdermal administration using PG, exhibiting similar characteristics to ES but with the added advantage of mass production capability.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240635"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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