Journal of The Royal Society Interface最新文献

Uncertainty in COVID-19 transmission could undermine our ability to predict long COVID.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-11 DOI: 10.1098/rsif.2024.0438

Alexander B Beams, David J D Earn, Caroline Colijn

{"title":"Uncertainty in COVID-19 transmission could undermine our ability to predict long COVID.","authors":"Alexander B Beams, David J D Earn, Caroline Colijn","doi":"10.1098/rsif.2024.0438","DOIUrl":"10.1098/rsif.2024.0438","url":null,"abstract":"As SARS-CoV-2 has transitioned from a novel pandemic-causing pathogen into an established seasonal respiratory virus, focus has shifted to post-acute sequelae of COVID-19 (PASC, colloquially 'long COVID'). We use compartmental mathematical models simulating emergence of new variants to help identify key sources of uncertainty in PASC trajectories. Some parameters (such as the duration and equilibrium prevalence of infection, as well as the fraction of infections that develop PASC) matter more than others (such as the duration of immunity and secondary vaccine efficacy against PASC). Even if newer variants carry the same risk of PASC as older types, the dynamics of selection can give rise to greater PASC prevalence. However, identifying plausible PASC prevalence trajectories requires accurate knowledge of the transmission potential of COVID-19 variants in the endemic phase. Precise estimates for secondary vaccine efficacy and duration of immunity will not greatly improve forecasts for PASC prevalence. Researchers involved with Living Evidence Synthesis, or other similar initiatives focused on PASC, are well advised to ascertain primary efficacy against infection, duration of infection and prevalence of active infection in order to facilitate predictions.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240438"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitric oxide modelling and its bioavailability influenced by red blood cells. 一氧化氮模型及其生物利用率受红细胞的影响。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0458

Ananta Kumar Nayak, Marco Canepari, Sovan Lal Das, Chaouqi Misbah

{"title":"Nitric oxide modelling and its bioavailability influenced by red blood cells.","authors":"Ananta Kumar Nayak, Marco Canepari, Sovan Lal Das, Chaouqi Misbah","doi":"10.1098/rsif.2024.0458","DOIUrl":"https://doi.org/10.1098/rsif.2024.0458","url":null,"abstract":"Nitric oxide (NO) is an important vasodilator responsible for maintaining vascular tone in the human body. Its production in endothelial cells (ECs) is regulated by the rise of cytoplasmic Ca2+ concentration and shear stress perceived by blood flow. The increase in cytoplasmic Ca2+ concentration is mainly activated by adenosine triphosphate (ATP) released from red blood cells (RBCs) and ECs. However, RBCs, which act as NO scavengers, can affect the bioavailability of NO in blood vessels. In this study, we developed a model that incorporates ATP and shear stress-dependent NO production, integrating various biochemical pathways. The model results are qualitatively consistent with the experimental findings. Given that ATP concentration and shear stress vary spatially within blood circulation, influenced by factors such as vessel width, flow strength and RBC concentration, these variations can significantly affect NO bioavailability. Here, we study RBC flow, ATP release from RBCs and ECs, and [Formula: see text] and NO dynamics in a two-dimensional channel using the immersed boundary lattice Boltzmann method. The main findings from the study include: (i) an increase in RBC concentration leads to a rise in ATP and cytoplasmic Ca2+ concentrations for all variation in channel widths, while NO concentration exhibits a decrease; (ii) NO bioavailability is significantly influenced by RBC distribution, particularly in strongly confined channels; and (iii) two phases of NO bioavailability are observed in different regions of the blood vessels: one with a significant concentration change at low RBC concentration and another with a minimal concentration change at high RBC concentration, across all confinements. The outcomes of this study may provide valuable insights into the mechanisms of NO-dependent vasodilation and the transport of oxygen by RBCs within microvascular networks for future studies.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240458"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: 'The three-dimensional coarse-graining formulation of interacting elastohydrodynamic filaments and multi-body microhydrodynamics' (2023), by Fuchter and Bloomfield-Gadêlha.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1098/rsif.2024.0800

Paul Fuchter, Hermes Bloomfield-Gadêlha

引用次数: 0

On the consequences of intra-operative release versus over-tensioning of the posterior cruciate ligament in total knee arthroplasty.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0588

Seyyed Hamed Hosseini Nasab, Sabrina Hörmann, Thomas M Grupp, William R Taylor, Allan Maas

{"title":"On the consequences of intra-operative release versus over-tensioning of the posterior cruciate ligament in total knee arthroplasty.","authors":"Seyyed Hamed Hosseini Nasab, Sabrina Hörmann, Thomas M Grupp, William R Taylor, Allan Maas","doi":"10.1098/rsif.2024.0588","DOIUrl":"https://doi.org/10.1098/rsif.2024.0588","url":null,"abstract":"Intra-operative tensioning of the posterior cruciate ligament (PCL) in total knee arthroplasty (TKA) is commonly based on the surgeon's experience, resulting in a possibly loose or overly tight PCL. To date, the consequences of different PCL tensioning scenarios for the post-operative biomechanics of the knee remain unclear. Using a comprehensive musculoskeletal modelling approach that allows predictive joint kinematic and kinetic balance, we assessed variations in the movement and loading patterns of the knee as well as changes in ligament and muscle forces during walking in response to systematic variations in the PCL reference strain. The results indicate only small differences in the tibiofemoral and patellofemoral kinematics and kinetics for scenarios involving up to 10% release of the PCL (relative to the baseline reference scenario with 2% residual strain). These observations remain valid for simulations performed with high- as well as with low-conformity implant designs. However, over-tensioning of the ligament was found to considerably overload the tibiofemoral joint, including altered contact mechanics, and may therefore shorten the implant longevity. Finally, no meaningful impact of the PCL reference strain on the muscle force patterns was observed. This study therefore favours balancing the knee with a slightly loose rather than tense PCL, if appropriate intra-operative PCL tension cannot be objectively achieved.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240588"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waveform geometry dictating optimal cruising in animals.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-11 DOI: 10.1098/rsif.2024.0442

Kazuko Yoshizawa, Ryosuke Motani

{"title":"Waveform geometry dictating optimal cruising in animals.","authors":"Kazuko Yoshizawa, Ryosuke Motani","doi":"10.1098/rsif.2024.0442","DOIUrl":"10.1098/rsif.2024.0442","url":null,"abstract":"For sustained swimming and flights, vertebrates and insects oscillate their propulsors periodically within a narrow range of Strouhal number (St), a dimensionless quantity describing the rate and density of the motion, suggesting a close relationship between the range and cruising optimality. The persistence of this range across size and fluids has puzzled biologists and engineers, resulting in multiple interpretations of its cause. Here, we propose that the optimal St range is largely constrained by power output efficiency of the trailing edge of the caudal fin. A mathematical model of the periodic wake of the trailing edge, which defines the proportion of power lost without contributing to propulsion, predicts that such energy loss is minimal in the observed range of St preferred by fish. The constraints apply across a range of Reynolds number in cruising fish. The same constraints dictate the optimal speed across a wide range of swimmers, in combination with morphological characteristics. Other factors such as drag properties also affect the optimal swimming speed, but probably to a smaller extent. The result that the geometry of periodic waveforms is key to cruising optimality provides an additional angle to study animal locomotion in fluids and related bioinspired robotics.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240442"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soft tissue can absorb surprising amounts of energy during knee exoskeleton use.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1098/rsif.2024.0539

W Sebastian Barrutia, Ada Yumiceva, Mai-Ly Thompson, Daniel P Ferris

{"title":"Soft tissue can absorb surprising amounts of energy during knee exoskeleton use.","authors":"W Sebastian Barrutia, Ada Yumiceva, Mai-Ly Thompson, Daniel P Ferris","doi":"10.1098/rsif.2024.0539","DOIUrl":"10.1098/rsif.2024.0539","url":null,"abstract":"Soft tissue at the human-exoskeleton interface can deform under load to absorb, return and dissipate the mechanical energy generated by the exoskeleton. These soft tissue effects are often not accounted for and may mislead researchers on the actual joint assistance an exoskeleton provides. We assessed the effects of soft tissue by quantifying the performance and energy distribution of a knee exoskeleton under different assistance strategies using a synthetic lower limb phantom. The phantom emulated knee kinematics and soft tissue deformation at the exoskeleton interface. We loaded the exoskeleton on the phantom under six different spring stiffness conditions. Motion capture marker and load cell data from the phantom-exoskeleton assembly allowed us to estimate the moments, stiffness and energy contributions of the exoskeleton and physical interface. We found that soft tissue caused interface power to increase and exoskeleton power to decrease with increasing spring stiffness. Despite similar joint kinematics, our findings show that increasing exoskeleton assistance did not notably change power transfer to the targeted joint, as soft tissue compressed under high forces. Our methodology improves exoskeleton design process by estimating energy distribution and transfer for exoskeletons while accounting for the effects of soft tissue deformation before human testing.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240539"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal contact patterns and the implications for predicting superspreaders and planning of targeted outbreak control.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0358

Rachael Pung, Josh A Firth, Timothy W Russell, Tim Rogers, Vernon J Lee, Adam J Kucharski

{"title":"Temporal contact patterns and the implications for predicting superspreaders and planning of targeted outbreak control.","authors":"Rachael Pung, Josh A Firth, Timothy W Russell, Tim Rogers, Vernon J Lee, Adam J Kucharski","doi":"10.1098/rsif.2024.0358","DOIUrl":"https://doi.org/10.1098/rsif.2024.0358","url":null,"abstract":"Directly transmitted infectious diseases spread through social contacts that change over time, but outbreak models typically make simplifying assumptions about network structure and dynamics. To assess how common assumptions relate to real-world interactions, we analysed 11 networks from five settings and developed metrics, capturing crucial epidemiological features of these networks. We developed a novel metric, the 'retention index', to characterize the distribution of retained contacts over consecutive time steps relative to fully static and dynamic networks. In workplaces and schools, contacts in the same department formed most of the retained contacts. In contrast, no clear contact type dominated the retained contacts in hospitals, thus reducing overall risk of disease introduction would be more effective than control targeted at departments. We estimated the contacts repetition over multiple days and showed that simple resource planning models overestimate the number of unique contacts by 20%-70%. We distinguished the difference between 'superspreader' and infectious individuals driving 'superspreading events' by measuring how often the individual represents the top 80% of contacts in the time steps over the study duration. We showed an inherent difficulty in identifying 'superspreaders' reliably: less than 20% of the individuals in most settings were highly connected for multiple time steps.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240358"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling individual variation in human walking gait across populations and walking conditions via gait recognition.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-11 DOI: 10.1098/rsif.2024.0565

Kayne A Duncanson, Fabian Horst, Ehsan Abbasnejad, Gary Hanly, William S P Robertson, Dominic Thewlis

{"title":"Modelling individual variation in human walking gait across populations and walking conditions via gait recognition.","authors":"Kayne A Duncanson, Fabian Horst, Ehsan Abbasnejad, Gary Hanly, William S P Robertson, Dominic Thewlis","doi":"10.1098/rsif.2024.0565","DOIUrl":"10.1098/rsif.2024.0565","url":null,"abstract":"Human walking gait is a personal story written by the body, a tool for understanding biological identity in healthcare and security. Gait analysis methods traditionally diverged between these domains but are now merging their complementary strengths to unlock new possibilities. Using large ground reaction force (GRF) datasets for gait recognition is a way to uncover subtle variations that define individual gait patterns. Previously, this was done by developing and evaluating machine learning models on the same individuals or the same dataset, potentially biasing findings towards population samples or walking conditions. This study introduces a new method for analysing gait variation across individuals, groups and datasets to explore how demographics and walking conditions shape individual gait patterns. Machine learning models were implemented using numerous configurations of four large walking GRF datasets from different countries (740 individuals, 7400 samples) and analysed using explainable artificial intelligence tools. Recognition accuracy ranged from 52 to 100%, with factors like footwear, walking speed and body mass playing interactive roles in defining gait. Models developed with individuals walking in personal footwear at multiple speeds effectively recognized novel individuals across populations and conditions (89-99% accuracy). Integrating force platform hardware and gait recognition software could be invaluable for reading the complex stories of human walking.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240565"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A global cross-cultural analysis of string figures reveals evidence of deep transmission and innovation.

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1098/rsif.2024.0673

Roope O Kaaronen, Matthew J Walsh, Allison K Henrich, Isobel Wisher, Elena Miu, Mikael A Manninen, Jussi T Eronen, Felix Riede

{"title":"A global cross-cultural analysis of string figures reveals evidence of deep transmission and innovation.","authors":"Roope O Kaaronen, Matthew J Walsh, Allison K Henrich, Isobel Wisher, Elena Miu, Mikael A Manninen, Jussi T Eronen, Felix Riede","doi":"10.1098/rsif.2024.0673","DOIUrl":"10.1098/rsif.2024.0673","url":null,"abstract":"Few cultural practices beyond language are as widespread as string figure games. Their global distribution and potential to yield insights into cultural transmission and cognition have long been noted. Yet, it remains unknown how or when this behaviour originated and to what extent shared motifs are signals of repeated innovations or deep cultural transmission. Here, we combined a global cross-cultural inventory of string figures with a novel methodology based on knot theory, which enables the unequivocal numerical coding of string figures. We performed a computational analysis of a sample of 826 figures from 92 societies around the world. Across these societies, we found 83 recurring string figure designs, some of which are regionally restricted while others display a global distribution. The cognitively opaque nature of string figure designs and their clear geographic distribution reveal processes of cultural transmission, innovation, and convergent evolution. Most strikingly, the global distribution of some figures raises the possibility of shared ancient origins.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240673"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weak-form inference for hybrid dynamical systems in ecology. 生态学中混合动力系统的弱形式推理。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0376

Daniel Messenger, Greg Dwyer, Vanja Dukic

{"title":"Weak-form inference for hybrid dynamical systems in ecology.","authors":"Daniel Messenger, Greg Dwyer, Vanja Dukic","doi":"10.1098/rsif.2024.0376","DOIUrl":"https://doi.org/10.1098/rsif.2024.0376","url":null,"abstract":"Species subject to predation and environmental threats commonly exhibit variable periods of population boom and bust over long timescales. Understanding and predicting such behaviour, especially given the inherent heterogeneity and stochasticity of exogenous driving factors over short timescales, is an ongoing challenge. A modelling paradigm gaining popularity in the ecological sciences for such multi-scale effects is to couple short-term continuous dynamics to long-term discrete updates. We develop a data-driven method utilizing weak-form equation learning to extract such hybrid governing equations for population dynamics and to estimate the requisite parameters using sparse intermittent measurements of the discrete and continuous variables. The method produces a set of short-term continuous dynamical system equations parametrized by long-term variables, and long-term discrete equations parametrized by short-term variables, allowing direct assessment of interdependencies between the two timescales. We demonstrate the utility of the method on a variety of ecological scenarios and provide extensive tests using models previously derived for epizootics experienced by the North American spongy moth (Lymantria dispar dispar).","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240376"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0