Journal of The Royal Society Interface最新文献_第10页

The 1978 English boarding school influenza outbreak: where the classic SEIR model fails. 1978 年英国寄宿学校流感爆发：经典 SEIR 模型的失败之处。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-20 DOI: 10.1098/rsif.2024.0394

Konstantin K Avilov, Qiong Li, Lixin Lin, Haydar Demirhan, Lewi Stone, Daihai He

{"title":"The 1978 English boarding school influenza outbreak: where the classic SEIR model fails.","authors":"Konstantin K Avilov, Qiong Li, Lixin Lin, Haydar Demirhan, Lewi Stone, Daihai He","doi":"10.1098/rsif.2024.0394","DOIUrl":"10.1098/rsif.2024.0394","url":null,"abstract":"Previous work has failed to fit classic SEIR epidemic models satisfactorily to the prevalence data of the famous English boarding school 1978 influenza A/H1N1 outbreak during the children's pandemic. It is still an open question whether a biologically plausible model can fit the prevalence time series and the attack rate correctly. To construct the final model, we first used an intentionally very flexible and overfitted discrete-time epidemiologic model to learn the epidemiological features from the data. The final model was a susceptible (S) - exposed (E) - infectious (I) - confined-to-bed (B) - convalescent (C) - recovered (R) model with time delay (constant residence time) in E and I compartments and multi-stage (Erlang-distributed residence time) in B and C compartments. We simultaneously fitted the reported B and C prevalence curves as well as the attack rate (proportion of children infected during the outbreak). The non-exponential residence times were crucial for good fits. The estimates of the generation time and the basic reproductive number ([Formula: see text]) were biologically reasonable. A simplified discrete-time model was built and fitted using the Bayesian procedure. Our work not only provided an answer to the open question, but also demonstrated an approach to constructive model generation.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240394"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11576841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring agent interaction patterns in the comment sections of fake and real news. 探索假新闻和真新闻评论区中的代理互动模式。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1098/rsif.2024.0483

Kailun Zhu, Songtao Peng, Jiaqi Nie, Zhongyuan Ruan, Shanqing Yu, Qi Xuan

引用次数: 0

Quantifying social media predictors of violence during the 6 January US Capitol insurrection using Granger causality. 利用格兰杰因果关系量化社交媒体对 1 月 6 日美国国会大厦暴动期间暴力事件的预测。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.1098/rsif.2024.0314

Qinghua Li, Brayden G King, Brian Uzzi

{"title":"Quantifying social media predictors of violence during the 6 January US Capitol insurrection using Granger causality.","authors":"Qinghua Li, Brayden G King, Brian Uzzi","doi":"10.1098/rsif.2024.0314","DOIUrl":"10.1098/rsif.2024.0314","url":null,"abstract":"Protests involving brute force are growing in number and are viewed as a likely source of increased collective violence in industrialized nations. Yet, our scientific understanding of how violent protests are related to a leader's social media communications during protests remains nascent. Here, we analyse new data from the 6 January 'march on the US Capitol' to quantify the links between leadership, social media and levels of violence. Using data on thousands of live footage videos, Trump's tweets and rally speech, other rally speeches and #StopTheSteal tweets, we apply Granger regression methods to analyse the links between former President Trump's tweets, #StopTheSteal tweets, rally speeches and the severity and duration of outbreaks of violence and weapons use during the riot. We find that Trump's tweets predict bursts in rioters' levels and duration of violence and weapons use. Trump's tweets also predict changes in the volume and sentiments of #StopTheSteal tweets, which in turn explain additional variance in levels of violence and weapons use over the course of the riot. Our findings reveal new patterns of behaviour that link an authority figure's online behaviour during a protest and the shift from peaceful protesting to violence.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240314"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of climate change and temperature extremes on Aedes albopictus populations: a regional case study for Italy. 气候变化和极端温度对白纹伊蚊种群的影响：意大利地区案例研究。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.1098/rsif.2024.0319

Miguel Garrido Zornoza, Cyril Caminade, Adrian M Tompkins

{"title":"The effect of climate change and temperature extremes on Aedes albopictus populations: a regional case study for Italy.","authors":"Miguel Garrido Zornoza, Cyril Caminade, Adrian M Tompkins","doi":"10.1098/rsif.2024.0319","DOIUrl":"10.1098/rsif.2024.0319","url":null,"abstract":"The Asian tiger mosquito, Aedes albopictus, has spread widely throughout Italy since its introduction, with significant public health implications. We examine how decadal temperature trends and sub-monthly heatwave events affect its climate-driven geographical distribution and temporal dynamics using a new regional-scale dynamical Aedes model. The model is calibrated using [Formula: see text] years of ovitrap data for Emilia-Romagna and reproduces the vector seasonality and, to a lesser extent, its inter-annual variability. Simulated vector density hotspots overlap with densely populated areas in Rome, Milan, Naples, Foggia, Catania, Palermo, Lecce, Cagliari, Genoa, Turin and large urban centres in Emilia-Romagna. Lower risk is simulated over the Central Apennine mountains and the Alps. At decadal time scale, we simulate a lengthening of the active mosquito season by 0.5-3 weeks per decade, with the vector becoming homodynamic in southern Italy. Depending on the climatic setting, heatwaves can increase or reduce vector populations and, in some locations, can temporarily decrease mosquito populations. Such decreases can be followed by a population rebound and overshoot. Given the model's skill in reproducing key spatio-temporal Ae. albopictus features, there is potential to develop an early warning system to inform control efforts at a national scale.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240319"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection. 用雷米地韦对 SARS-CoV-2 感染进行抗病毒治疗的宿主内动态变化。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1098/rsif.2024.0536

Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis

{"title":"Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection.","authors":"Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis","doi":"10.1098/rsif.2024.0536","DOIUrl":"10.1098/rsif.2024.0536","url":null,"abstract":"The effectiveness of antiviral treatment with remdesivir against COVID-19 has been investigated in clinical trials suggesting earlier recovery. However, this effect seems to be rather modest. In this study, we tracked the clinical course of SARS-CoV-2 infections in 369 COVID-19 individuals across a spectrum of illness severities, including both untreated individuals and individuals who received antiviral treatment with remdesivir. Moreover, using a process-based mathematical model, we quantified and analysed the within-host infection dynamics of a total of 88 individuals, of which 69 were untreated and 19 antiviral-treated individuals. For untreated individuals, we found that those hospitalized exhibit lower levels of early immune response and higher cumulative viral loads than those who were not. For treated individuals, we found that those who died were on average hospitalized later after symptom onset than those who survived, underscoring the importance of early medical intervention for severe COVID-19. Finally, our model estimates a rather limited antiviral activity of remdesivir. Our results provide valuable insights into the clinical course of COVID-19 during antiviral treatment with remdesivir and suggest the need for alternative treatment regimens.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240536"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue. 输液方向对各向异性组织对流增强给药的影响

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-02 DOI: 10.1098/rsif.2024.0378

Yi Yang, Tian Yuan, Ferdinando Rodriguez Y Baena, Daniele Dini, Wenbo Zhan

{"title":"Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue.","authors":"Yi Yang, Tian Yuan, Ferdinando Rodriguez Y Baena, Daniele Dini, Wenbo Zhan","doi":"10.1098/rsif.2024.0378","DOIUrl":"10.1098/rsif.2024.0378","url":null,"abstract":"Convection-enhanced delivery (CED) can effectively overcome the blood-brain barrier by infusing drugs directly into diseased sites in the brain using a catheter, but its clinical performance still needs to be improved. This is strongly related to the highly anisotropic characteristics of brain white matter, which results in difficulties in controlling drug transport and distribution in space. In this study, the potential to improve the delivery of six drugs by adjusting the placement of the infusion catheter is examined using a mathematical model and accurate numerical simulations that account simultaneously for the interstitial fluid (ISF) flow and drug transport processes in CED. The results demonstrate the ability of this direct infusion to enhance ISF flow and therefore facilitate drug transport. However, this enhancement is highly anisotropic, subject to the orientation of local axon bundles and is limited within a small region close to the infusion site. Drugs respond in different ways to infusion direction: the results of our simulations show that while some drugs are almost insensitive to infusion direction, this strongly affects other compounds in terms of isotropy of drug distribution from the catheter. These findings can serve as a reference for planning treatments using CED.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240378"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: 'Impact of infectious diseases on wild Bovidae populations in Thailand: insights from population modelling and disease dynamics' (2024), by Horpiencharoen et al. 更正："传染病对泰国野生牛科种群的影响：种群建模和疾病动态的启示"（2024 年），作者 Horpiencharoen 等人。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.1098/rsif.2024.0610

Wantida Horpiencharoen, Jonathan C Marshall, Renata L Muylaert, Reju Sam John, David Hayman

引用次数: 0

A model of task-level human stepping regulation yields semistable walking. 任务级人类步态调节模型可实现半稳定行走。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1098/rsif.2024.0151

Navendu S Patil, Jonathan B Dingwell, Joseph P Cusumano

{"title":"A model of task-level human stepping regulation yields semistable walking.","authors":"Navendu S Patil, Jonathan B Dingwell, Joseph P Cusumano","doi":"10.1098/rsif.2024.0151","DOIUrl":"10.1098/rsif.2024.0151","url":null,"abstract":"A simple lateral dynamic walker, with swing leg dynamics and three adjustable input parameters, is used to study how motor regulation affects frontal-plane stepping. Motivated by experimental observations and phenomenological models, we imposed task-level multi-objective regulation targeting the walker's optimal lateral foot placement at each step. The regulator prioritizes achieving step width and lateral body position goals to varying degrees by choosing a mixture parameter. Our model thus integrates a lateral mechanical template, which captures the fundamental mechanics of frontal-plane walking, with a lateral motor regulation template, an empirically verified model of how humans manipulate lateral foot placements in a goal-directed manner. The model captures experimentally observed stepping fluctuation statistics and demonstrates how linear empirical models of stepping dynamics can emerge from first-principles nonlinear mechanics. We find that task-level regulation gives rise to a goal-equivalent manifold in the system's extended state space of mechanical states and inputs, a subset of which contains a continuum of period-1 gaits forming a semistable set: perturbations off of any of its gaits result in transients that return to the set, though typically to different gaits.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240151"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding burst swimming performance: a scaling perspective on time-to-fatigue. 解码爆发性游泳成绩：从时间到疲劳的比例视角。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-02 DOI: 10.1098/rsif.2024.0276

Muhammad Usama Ashraf, Daniel Nyqvist, Claudio Comoglio, Vladimir Nikora, Andrea Marion, Paolo Domenici, Costantino Manes

{"title":"Decoding burst swimming performance: a scaling perspective on time-to-fatigue.","authors":"Muhammad Usama Ashraf, Daniel Nyqvist, Claudio Comoglio, Vladimir Nikora, Andrea Marion, Paolo Domenici, Costantino Manes","doi":"10.1098/rsif.2024.0276","DOIUrl":"10.1098/rsif.2024.0276","url":null,"abstract":"Fatigue curves quantify fish swimming performance, providing information about the time ([Formula: see text]) fish can swim against a steady flow velocity (Uf) before fatiguing. Such curves represent a key tool for many applications in ecological engineering, especially for fish pass design and management. Despite years of research, though, our current ability to model fatigue curves still lacks theoretical foundations and relies primarily on fitting empirical data, as obtained from time-consuming and costly experiments. In the present article, we address this shortcoming by proposing a theoretical analysis that builds upon concepts of fish hydrodynamics to derive scaling laws linking statistical properties of [Formula: see text] to velocities Uf, pertaining to the so-called burst range. Theoretical arguments, in the present study, suggest that the proposed scaling laws may hold true for all fish species and sizes. A new experimental database obtained from over 800 trials and five small-sized Cypriniformes support theoretical predictions satisfactorily and calls for further experiments on more fish species and sizes to confirm their general validity.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240276"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism. 用瞬态反常扩散形式分析寄生线虫成虫在性别混合群体中的聚集。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1098/rsif.2024.0327

Ruth Leben, Sebastian Rausch, Laura Elomaa, Anja E Hauser, Marie Weinhart, Sabine C Fischer, Holger Stark, Susanne Hartmann, Raluca Niesner

{"title":"Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism.","authors":"Ruth Leben, Sebastian Rausch, Laura Elomaa, Anja E Hauser, Marie Weinhart, Sabine C Fischer, Holger Stark, Susanne Hartmann, Raluca Niesner","doi":"10.1098/rsif.2024.0327","DOIUrl":"10.1098/rsif.2024.0327","url":null,"abstract":"Intestinal parasitic worms are widespread throughout the world, causing chronic infections in humans and animals. However, very little is known about the locomotion of the worms in the host gut. We studied the movement of Heligmosomoides bakeri, naturally infecting mice, and used as an animal model for roundworm infections. We investigated the locomotion of H. bakeri in simplified environments mimicking key physical features of the intestinal lumen, i.e. medium viscosity and intestinal villi topology. We found that the motion sequence of these nematodes is non-periodic, but the migration could be described by transient anomalous diffusion. Aggregation as a result of biased, enhanced-diffusive locomotion of nematodes in sex-mixed groups was detected. This locomotion is probably stimulated by mating and reproduction, while single nematodes move randomly (diffusive). Natural physical obstacles such as high mucus-like viscosity or villi topology slowed down but did not entirely prevent nematode aggregation. Additionally, the mean displacement rate of nematodes in sex-mixed groups of 3.0 × 10-3 mm s-1 in a mucus-like medium is in good agreement with estimates of migration velocities of 10-4 to 10-3 mm s-1 in the gut. Our data indicate H. bakeri motion to be non-periodic and their migration random (diffusive-like), but triggerable by the presence of kin.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240327"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0