Journal of The Royal Society Interface最新文献_第9页

Weak-form inference for hybrid dynamical systems in ecology. 生态学中混合动力系统的弱形式推理。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0376

Daniel Messenger, Greg Dwyer, Vanja Dukic

{"title":"Weak-form inference for hybrid dynamical systems in ecology.","authors":"Daniel Messenger, Greg Dwyer, Vanja Dukic","doi":"10.1098/rsif.2024.0376","DOIUrl":"10.1098/rsif.2024.0376","url":null,"abstract":"Species subject to predation and environmental threats commonly exhibit variable periods of population boom and bust over long timescales. Understanding and predicting such behaviour, especially given the inherent heterogeneity and stochasticity of exogenous driving factors over short timescales, is an ongoing challenge. A modelling paradigm gaining popularity in the ecological sciences for such multi-scale effects is to couple short-term continuous dynamics to long-term discrete updates. We develop a data-driven method utilizing weak-form equation learning to extract such hybrid governing equations for population dynamics and to estimate the requisite parameters using sparse intermittent measurements of the discrete and continuous variables. The method produces a set of short-term continuous dynamical system equations parametrized by long-term variables, and long-term discrete equations parametrized by short-term variables, allowing direct assessment of interdependencies between the two timescales. We demonstrate the utility of the method on a variety of ecological scenarios and provide extensive tests using models previously derived for epizootics experienced by the North American spongy moth (Lymantria dispar dispar).","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240376"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trade-off between the antiviral and vaccinal effects of antibody therapy in the humoral response to HIV. 在HIV体液应答中，抗体治疗的抗病毒和疫苗效应之间的权衡。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1098/rsif.2024.0535

Soumya Mittal, Amar K Garg, Rajat Desikan, Narendra M Dixit

{"title":"Trade-off between the antiviral and vaccinal effects of antibody therapy in the humoral response to HIV.","authors":"Soumya Mittal, Amar K Garg, Rajat Desikan, Narendra M Dixit","doi":"10.1098/rsif.2024.0535","DOIUrl":"10.1098/rsif.2024.0535","url":null,"abstract":"Antibody therapy for HIV-1 infection exerts two broad effects: a drug-like, antiviral effect, which rapidly lowers the viral load, and a vaccinal effect, which may control the viral load long-term by improving the immune response. Here, we elucidate a trade-off between these two effects as they pertain to the humoral response, which may compromise antibody therapy aimed at eliciting long-term HIV-1 remission. We developed a multi-scale computational model that combined within-host viral dynamics and stochastic simulations of the germinal centre (GC) reaction, enabling simultaneous quantification of the antiviral and vaccinal effects of antibody therapy. The model predicted that increasing antibody dosage or antibody-antigen affinity increased immune complex formation and enhanced GC output. Beyond a point, however, a strong antiviral effect reduced antigen levels substantially, extinguishing GCs and limiting the humoral response. We found signatures of this trade-off in clinical studies. Accounting for the trade-off could be important in optimizing antibody therapy for HIV-1 remission.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240535"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamics of positional information in the vertebrate neural tube. 脊椎动物神经管中位置信息的动力学。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-11 DOI: 10.1098/rsif.2024.0414

Anđela Marković, James Briscoe, Karen M Page

{"title":"Dynamics of positional information in the vertebrate neural tube.","authors":"Anđela Marković, James Briscoe, Karen M Page","doi":"10.1098/rsif.2024.0414","DOIUrl":"10.1098/rsif.2024.0414","url":null,"abstract":"In developing embryos, cells acquire distinct identities depending on their position in a tissue. Secreted signalling molecules, known as morphogens, act as long-range cues to provide the spatial information that controls these cell fate decisions. In several tissues, both the level and the duration of morphogen signalling appear to be important for determining cell fates. This is the case in the forming vertebrate nervous system where antiparallel morphogen gradients pattern the dorsal-ventral axis by partitioning the tissue into sharply delineated domains of molecularly distinct neural progenitors. How information in the gradients is decoded to generate precisely positioned boundaries of gene expression remains an open question. Here, we adopt tools from information theory to quantify the positional information in the neural tube and investigate how temporal changes in signalling could influence positional precision. The results reveal that the use of signalling dynamics, as well as the signalling level, substantially increases the precision possible for the estimation of position from morphogen gradients. This analysis links the dynamics of opposing morphogen gradients with precise pattern formation and provides an explanation for why time is used to impart positional information.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240414"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Collective effect of self-learning and social learning on language dynamics: a naming game approach in social networks. 自我学习和社会学习对语言动态的集体效应：社会网络中的命名游戏方法。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-04 DOI: 10.1098/rsif.2024.0406

Tao Wen, Yu-Wang Chen, Renaud Lambiotte

{"title":"Collective effect of self-learning and social learning on language dynamics: a naming game approach in social networks.","authors":"Tao Wen, Yu-Wang Chen, Renaud Lambiotte","doi":"10.1098/rsif.2024.0406","DOIUrl":"10.1098/rsif.2024.0406","url":null,"abstract":"Linguistic rules form the cornerstone of human communication, enabling people to understand and interact with one another effectively. However, there are always irregular exceptions to regular rules, with one of the most notable being the past tense of verbs in English. In this work, a naming game approach is developed to investigate the collective effect of social behaviours on language dynamics, which encompasses social learning, self-learning with preference and forgetting due to memory constraints. Two features that pertain to individuals' influential ability and affinity are introduced to assess an individual's role of social influence and discount the information they communicate in the Bayesian inference-based social learning model. Our findings suggest that network heterogeneity and community structure significantly impact language dynamics, as evidenced in synthetic and real-world networks. Furthermore, self-learning significantly enhances the process of language regularization, while forgetting has a relatively minor impact. The results highlight the substantial influence of network structure and social behaviours on the transition of opinions, from consensus to polarization, demonstrating its importance in language dynamics. This work sheds new light on how individual learners adopt language rules through the lenses of complexity science and decision science, advancing our understanding of language dynamics.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240406"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantification of Trypanosoma brucei social motility indicates different colony growth phases. 布鲁氏锥虫的社会运动量化表明不同的菌落生长阶段。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-12-01 Epub Date: 2024-12-18 DOI: 10.1098/rsif.2024.0469

Andreas Kuhn, Timothy Krüger, Magdalena Schüttler, Markus Engstler, Sabine C Fischer

{"title":"Quantification of Trypanosoma brucei social motility indicates different colony growth phases.","authors":"Andreas Kuhn, Timothy Krüger, Magdalena Schüttler, Markus Engstler, Sabine C Fischer","doi":"10.1098/rsif.2024.0469","DOIUrl":"10.1098/rsif.2024.0469","url":null,"abstract":"In vitro colonies of the flagellated parasite Trypanosoma brucei exhibit characteristic fingering instability patterns. To enable data-driven and data-validated mechanistic modelling of these complex growth processes, it is crucial to first establish appropriate quantitative metrics beyond qualitative image comparisons. We present a quantification approach based on two scale-free metrics designed to characterize the shape of two-dimensional colonies. Originally developed for yeast colonies, we adapted, modified and extended this analysis pipeline for the Trypanosoma system. By combining these quantitative measurements with colony growth simulations based on the Eden model, we identified two distinct growth phases in social motility-exhibiting colonies: an initial phase of mainly circular expansion, followed by a transition to an almost exclusive finger-growing phase. These phases remain robust with increasing cell numbers and upon partial inhibition of finger formation. A newly developed anisotropy index reveals that partial inhibition leads to increased colony anisotropy over time. Our results provide objective measurements that advance the understanding of social motility and serve as a foundation for future mechanistic modelling efforts. Furthermore, our approach offers a blueprint for investigations of other colony-forming microorganisms, such as yeast or bacteria, emphasizing the broader applicability of developing appropriate metrics for complex biological phenomena.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 221","pages":"20240469"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model-informed optimal allocation of limited resources to mitigate infectious disease outbreaks in societies at war. 根据模型优化有限资源的分配，以缓解战争社会中传染病的爆发。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-06 DOI: 10.1098/rsif.2024.0575

Vaibhava Srivastava, Drik Sarkar, Claus Kadelka

{"title":"Model-informed optimal allocation of limited resources to mitigate infectious disease outbreaks in societies at war.","authors":"Vaibhava Srivastava, Drik Sarkar, Claus Kadelka","doi":"10.1098/rsif.2024.0575","DOIUrl":"10.1098/rsif.2024.0575","url":null,"abstract":"Infectious diseases thrive in war-torn societies. The recent sharp increase in human conflict and war thus requires the development of disease mitigation tools that account for the specifics of war, such as the scarcity of important public health resources. We developed a compartmental, differential equation-based disease model that considers key social, war and disease mechanisms, such as gender homophily and the replacement of soldiers. This model enables the identification of optimal allocation strategies that, given limited resources required for treating infected individuals, minimize disease burden, assessed by total mortality and final epidemic size. A comprehensive model analysis reveals that the level of resource scarcity fundamentally affects the optimal allocation. Desynchronization of the epidemic peaks among several population subgroups emerges as a desirable principle since it reduces disease spread between different subgroups. Further, the level of preferential mixing among people of the same gender, gender homophily, proves to strongly affect disease dynamics and optimal treatment allocation strategies, highlighting the importance of accurately accounting for heterogeneous mixing patterns. Altogether, the findings help answer a timely question: how can infectious diseases be best controlled in societies at war? The developed model can be easily extended to specific diseases, countries and interventions.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240575"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11538904/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upper bill bending as an adaptation for nectar feeding in hummingbirds. 上喙弯曲是蜂鸟取食花蜜的一种适应。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1098/rsif.2024.0286

Alejandro Rico-Guevara, Diego Sustaita, Kristiina J Hurme, Jenny E Hanna, Sunghwan Jung, Daniel J Field

{"title":"Upper bill bending as an adaptation for nectar feeding in hummingbirds.","authors":"Alejandro Rico-Guevara, Diego Sustaita, Kristiina J Hurme, Jenny E Hanna, Sunghwan Jung, Daniel J Field","doi":"10.1098/rsif.2024.0286","DOIUrl":"10.1098/rsif.2024.0286","url":null,"abstract":"Observations of maxillary (upper bill) bending in hummingbirds have been considered an optical illusion, yet a recent description of out-of-phase opening and closing between their bill base and tip suggests a genuine capacity for bill bending. We investigate bill kinematics during nectar feeding in six species of hummingbirds. We employed geometric morphometrics to identify bending zones and combined these data with measurements of bill flexural rigidity from micro-computed tomography scans to better understand the flexing mechanism. We found that the mandible remains in place throughout the licking cycle, while the maxilla undergoes significant shape deformation, such that the distal portion of the upper bill bends upwards. We propose that bill bending is a key component of the drinking mechanism in hummingbirds, allowing the coordination of bill function (distal wringing and basal expansion) and tongue function (raking/squeegeeing) during intra-oral transport. We present a fluid analysis that reveals a combination of pressure-driven (Poiseuille) and boundary-driven (Couette) flows, which have previously been thought to represent alternative drinking mechanisms. Bill bending allows for separation of the bill tips while maintaining a tightly closed middle section of the bill, enabling nectar exploitation in long and narrow flowers that can exclude less efficient pollinators.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240286"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11601124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The suppression of ocean waves by biogenic slicks. 生物浮渣对海浪的压制。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-13 DOI: 10.1098/rsif.2024.0385

Nathan J M Laxague, Christopher J Zappa, Shantanu Soumya, Oliver Wurl

{"title":"The suppression of ocean waves by biogenic slicks.","authors":"Nathan J M Laxague, Christopher J Zappa, Shantanu Soumya, Oliver Wurl","doi":"10.1098/rsif.2024.0385","DOIUrl":"10.1098/rsif.2024.0385","url":null,"abstract":"Ocean waves are significantly damped by biogenic surfactants, which accumulate at the sea surface in every ocean basin. The growth, development, and breaking of short wind-driven surface waves are key mediators of the air-sea exchange of momentum, heat and trace gases. The mechanisms through which surfactants suppress waves have been studied in great detail through careful laboratory experimentation in quasi-one-dimensional wave tanks. However, the spatial scales over which this damping occurs in structurally complex surfactant slicks on the real ocean have not been resolved. Here, we present the results of field observations of the spatial response of decimetre- to millimetre-scale waves to biogenic surfactant slicks. We found that wave damping in organic material-rich coastal waters resulted in a net (spatio-temporally averaged) reduction of approximately 50% in wave slope variance relative to the open ocean for low to moderate wind speeds. This reduction of wave slope variance is understood to result in a corresponding reduction in momentum input to the wave field. This significant effect had thus far evaded quantification due in large part to the enormous range of scales required for its description-spanning the sea surface microlayer to the ocean submesoscale.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240385"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evolutionary mechanisms that promote cooperation may not promote social welfare. 促进合作的进化机制未必能促进社会福利。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1098/rsif.2024.0547

The Anh Han, Manh Hong Duong, Matjaz Perc

{"title":"Evolutionary mechanisms that promote cooperation may not promote social welfare.","authors":"The Anh Han, Manh Hong Duong, Matjaz Perc","doi":"10.1098/rsif.2024.0547","DOIUrl":"10.1098/rsif.2024.0547","url":null,"abstract":"Understanding the emergence of prosocial behaviours among self-interested individuals is an important problem in many scientific disciplines. Various mechanisms have been proposed to explain the evolution of such behaviours, primarily seeking the conditions under which a given mechanism can induce highest levels of cooperation. As these mechanisms usually involve costs that alter individual pay-offs, it is, however, possible that aiming for highest levels of cooperation might be detrimental for social welfare-the latter broadly defined as the total population pay-off, taking into account all costs involved for inducing increased prosocial behaviours. Herein, by comparing stochastic evolutionary models of two well-established mechanisms of prosocial behaviour-namely, peer and institutional incentives-we demonstrate that the objectives of maximizing cooperation and of maximizing social welfare are often misaligned. First, while peer punishment is often more effective than peer reward in promoting cooperation-especially with a higher impact-to-cost ratio-the opposite is true for social welfare. In fact, welfare typically decreases (increases) with this ratio for punishment (reward). Second, for institutional incentives, while maintaining similar levels of cooperation, rewards result in positive social welfare across a much broader range of parameters. Furthermore, both types of incentives often achieve optimal social welfare when their impact is moderate rather than maximal, indicating that careful planning is essential for costly institutional mechanisms to optimize social outcomes. These findings are consistent across varying mutation rates, selection intensities and game configurations. Overall, we argue for the need of adopting social welfare as the main optimization objective when designing and implementing evolutionary mechanisms for social and collective goods.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240547"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global and local identifiability analysis of a nonlinear biphasic constitutive model in confined compression. 约束压缩非线性双相构造模型的全局和局部可识别性分析

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-13 DOI: 10.1098/rsif.2024.0415

John M Peloquin, Dawn M Elliott

{"title":"Global and local identifiability analysis of a nonlinear biphasic constitutive model in confined compression.","authors":"John M Peloquin, Dawn M Elliott","doi":"10.1098/rsif.2024.0415","DOIUrl":"10.1098/rsif.2024.0415","url":null,"abstract":"Application of biomechanical models relies on model parameters estimated from experimental data. Parameter non-identifiability, when the same model output can be produced by many sets of parameter values, introduces severe errors yet has received relatively little attention in biomechanics and is subtle enough to remain unnoticed in the absence of deliberate verification. The present work develops a global identifiability analysis method in which cluster analysis and singular value decomposition are applied to vectors of parameter-output variable correlation coefficients. This method provides a visual representation of which specific experimental design elements are beneficial or harmful in terms of parameter identifiability, supporting the correction of deficiencies in the test protocol prior to testing physical specimens. The method was applied to a representative nonlinear biphasic model for cartilaginous tissue, demonstrating that confined compression data does not provide identifiability for the biphasic model parameters. This result was confirmed by two independent analyses: local analysis of the Hessian of a sum-of-squares error cost function and observation of the behaviour of two optimization algorithms. Therefore, confined compression data are insufficient for the calibration of general-purpose biphasic models. Identifiability analysis by these or other methods is strongly recommended when planning future experiments.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240415"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142623197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0