Journal of The Royal Society Interface最新文献_第8页

The sensible senseless person: a theoretical framework for clinical assessment of proprioception. 理性无知觉者：本体感觉临床评估的理论框架。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2026.1345

Yogev Koren, Asaf Cohen, Noy Goldhamer, Lior Shmuelof

{"title":"The sensible senseless person: a theoretical framework for clinical assessment of proprioception.","authors":"Yogev Koren, Asaf Cohen, Noy Goldhamer, Lior Shmuelof","doi":"10.1098/rsif.2026.1345","DOIUrl":"10.1098/rsif.2026.1345","url":null,"abstract":"Position-matching is a common task used to assess the sense of position, a sub-modality of proprioception. The 'sensible senseless person' (SSP), a theoretical construct that lacks sensory perception but is capable of logical inference, was developed to critically evaluate common outcome measures in such tasks. This framework reveals that traditional measures are influenced by task structure, strategic responses and the prior beliefs of the SSP. To address these limitations, we propose the Guess Index (GI), an outcome measure designed to ensure that the SSP receives the same score regardless of task or personal parameters. To demonstrate the GI's utility, we applied a simplified, clinically oriented position-matching task to healthy individuals and persons with stroke. Participants' performance often followed the SSP-predicted pattern. The GI correlated with traditional outcome measures, but was more sensitive to group differences and the only metric that classified persons with stroke above chance level in this dataset. Future studies should extend this framework to other proprioceptive sub-modalities and larger, more diverse populations before the GI can be considered a general index of proprioceptive adequacy with robust clinical cutoffs.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modelling the biomechanics of the human iris with an active strain approach. 用主动应变方法模拟人类虹膜的生物力学。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2025.1363

Kevin R Lucón Rivas, Michele Bucelli, Luca Dedè, Anna Pandolfi

{"title":"Modelling the biomechanics of the human iris with an active strain approach.","authors":"Kevin R Lucón Rivas, Michele Bucelli, Luca Dedè, Anna Pandolfi","doi":"10.1098/rsif.2025.1363","DOIUrl":"10.1098/rsif.2025.1363","url":null,"abstract":"The iris is a deformable circular diaphragm that regulates pupil size in response to changes in illumination through the antagonistic actions of sphincter and dilator muscles. While the phenomenological relationship between pupil size and light intensity is well studied, the mechanical interplay between active muscle contraction and passive iris tissue remains poorly understood. In this study, we develop a finite-element model of the human iris using an active strain formulation to investigate the mechanics underlying pupil regulation under physiological conditions. The iris is represented as a fibre-reinforced soft tissue, with passive matrix behaviour modelled as isotropic, nonlinear elastic and active muscle contraction introduced via contractive strains along fibre directions. Numerical simulations are performed using a dedicated finite-element code. By progressively including active and passive tissue components, we analyse how tissue architecture affects pupil kinematics, stress distribution and interaction with supporting boundaries at the iris root. Results reveal a counterintuitive yet significant role of passive tissues in shaping three-dimensional iris deformation and moderating boundary reactions. This computational framework provides a mechanically consistent basis for understanding iris biomechanics and can support future studies extending to more complex physiological or pathological conditions.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The case for using flexible healthcare capacity constraints to optimize pandemic control strategies. 利用灵活的卫生保健能力限制优化大流行控制战略的理由。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2025.1046

Nathan J Doyle, Fergus Cumming, Thomas J R Finnie, Michael West, Robin N Thompson, Michael J Tildesley

{"title":"The case for using flexible healthcare capacity constraints to optimize pandemic control strategies.","authors":"Nathan J Doyle, Fergus Cumming, Thomas J R Finnie, Michael West, Robin N Thompson, Michael J Tildesley","doi":"10.1098/rsif.2025.1046","DOIUrl":"10.1098/rsif.2025.1046","url":null,"abstract":"During the COVID-19 pandemic, a key challenge was designing control strategies that balance the benefits and costs of public health measures while preventing healthcare systems from becoming overwhelmed. This was often addressed by epidemiological modellers by implementing a binding (hard) constraint based on the maximum number of hospital beds that could be occupied at any given time. However, experience from the pandemic demonstrated that healthcare capacity depends not only on bed availability, but also on staffing and the availability of other resources. We argue that defining healthcare capacity using a single number (bed availability) does not adequately capture long-term pressures in healthcare settings as high occupancy is sustained. We therefore introduce a framework for implementing flexible (soft) constraints on healthcare capacity by allowing the cost of control strategies to depend continuously on intensive care unit occupancy. We illustrate scenarios where a soft constraint captures pressures on the healthcare system that are neglected when a hard constraint is used. Additionally, we highlight that explicitly accounting for uncertainty is essential to choosing a robust strategy. For the most useful evidence to be provided to policy advisors during future pandemics, modellers should consider how healthcare capacity constraints are implemented in epidemiological models.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity of fish stock trajectories to climate forcing and human exploitation at a global scale. 全球范围内鱼类种群轨迹对气候强迫和人类开发的敏感性。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2025.1040

Raphaël Benerradi, Vasilis Dakos, Alejandro V Cano

{"title":"Sensitivity of fish stock trajectories to climate forcing and human exploitation at a global scale.","authors":"Raphaël Benerradi, Vasilis Dakos, Alejandro V Cano","doi":"10.1098/rsif.2025.1040","DOIUrl":"10.1098/rsif.2025.1040","url":null,"abstract":"Global fisheries are under increasing pressure from overfishing and climate change, threatening marine biodiversity and food security. Disentangling the impacts of these two drivers is essential for sustainable management, yet it remains a major challenge due to the complex nature of marine ecosystems. Here, we utilize a data-driven empirical dynamic modelling framework to assess causal relationships between harvest rate, sea surface temperature (SST), and the productivity of 155 fish stocks worldwide. Our analysis identifies fishing pressure as the most prevalent driver of stock productivity, with a causal link detected in 71 stocks (45.8%). SST was also identified as a significant driver of productivity in 39 stocks (25.2%). While the impact of harvest rate was stock-specific, being either positive or negative, the influence of SST was predominantly negative and, in many cases, intensified over time. These results provide empirical evidence that direct exploitation and climate warming are systematically impacting fish stock productivity, with direct exploitation emerging as the predominant driver across stocks. This predominance suggests that improved harvest management could help buffer or mitigate some of the negative impacts of climate warming on fisheries productivity.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An improved inverse method for estimating disease transmission rates in epidemics with low-incidence data. 基于低发病率数据估计传染病传播率的改进逆方法。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2026.0044

Shuanglin Jing, Yuting Huang, Hai-Feng Huo

{"title":"An improved inverse method for estimating disease transmission rates in epidemics with low-incidence data.","authors":"Shuanglin Jing, Yuting Huang, Hai-Feng Huo","doi":"10.1098/rsif.2026.0044","DOIUrl":"10.1098/rsif.2026.0044","url":null,"abstract":"The accurate estimation of time-varying transmission rates is fundamental for understanding infectious disease dynamics and implementing effective public health interventions. To this end, we propose an improved inverse method for estimating time-varying transmission rates in low-incidence settings, where conventional data pre-processing approaches often fail owing to sparse-case observations. To overcome this difficulty, we introduce an exponential B-spline interpolation approach that integrates both continuous and discrete inverse methods. In addition, we incorporate a non-standard finite-difference method, which enables the reconstruction of epidemic processes under non-equidistant time intervals caused by missing case data. This method ensures that transmission rate estimates remain non-negative and smooth, even when the observed data exhibit low cases or irregularly spaced time points. We apply this approach to several infectious disease models using real-world data from the People's Republic of China and Germany, including a scarlet fever model, a multi-strain influenza model and an age-structured influenza model, as well as a COVID-19 model for Germany. The results show that our method provides accurate transmission rate estimates, particularly in low-incidence infectious diseases, multi-group epidemic models and epidemic datasets with incomplete surveillance records, demonstrating its robustness and applicability across various epidemiological contexts. The improved inverse method offers a new perspective for epidemiological modelling and provides reliable technical support for related theoretical exploration and public health decision-making.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sensible senseless person: a theoretical framework for clinical assessment of proprioception. 理性无知觉者：本体感觉临床评估的理论框架。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2025.1345

Yogev Koren, Asaf Cohen, Noy Goldhamer, Lior Shmuelof

{"title":"The sensible senseless person: a theoretical framework for clinical assessment of proprioception.","authors":"Yogev Koren, Asaf Cohen, Noy Goldhamer, Lior Shmuelof","doi":"10.1098/rsif.2025.1345","DOIUrl":"10.1098/rsif.2025.1345","url":null,"abstract":"Position-matching is a common task used to assess the sense of position, a sub-modality of proprioception. The 'sensible senseless person' (SSP), a theoretical construct that lacks sensory perception but is capable of logical inference, was developed to critically evaluate common outcome measures in such tasks. This framework reveals that traditional measures are influenced by task structure, strategic responses and the prior beliefs of the SSP. To address these limitations, we propose the Guess Index (GI), an outcome measure designed to ensure that the SSP receives the same score regardless of task or personal parameters. To demonstrate the GI's utility, we applied a simplified, clinically oriented position-matching task to healthy individuals and persons with stroke. Participants' performance often followed the SSP-predicted pattern. The GI correlated with traditional outcome measures, but was more sensitive to group differences and the only metric that classified persons with stroke above chance level in this dataset. Future studies should extend this framework to other proprioceptive sub-modalities and larger, more diverse populations before the GI can be considered a general index of proprioceptive adequacy with robust clinical cutoffs.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dissent enhances the credibility of groups of Bayesian conformist decision-makers. 不同意见增强了贝叶斯循规蹈矩的决策者群体的可信度。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-05 DOI: 10.1098/rsif.2025.0956

Aurèle Boussard, Richard P Mann, Alfonso Pérez-Escudero

{"title":"Dissent enhances the credibility of groups of Bayesian conformist decision-makers.","authors":"Aurèle Boussard, Richard P Mann, Alfonso Pérez-Escudero","doi":"10.1098/rsif.2025.0956","DOIUrl":"10.1098/rsif.2025.0956","url":null,"abstract":"When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimation provides tools for modelling decisions that optimally balance these two sources of information and can incorporate empirically documented cognitive biases, such as the conformity bias, which promotes consensus at the expense of accuracy. We use this framework to analyse a situation in which an uninformed individual judges the accuracy of a group of informed individuals-a situation relevant in human societies, where citizens routinely follow recommendations provided by groups of experts. In the absence of conformity bias, group accuracy increases monotonically with agreement level, suggesting that unanimity is a reliable indicator of trustworthiness. However, a more realistic model that describes groups with different degrees of conformity shows that unanimity is not an indicator of high reliability. Instead, the most reliable groups are those with relatively high levels of agreement, but not reaching total consensus. This result shows that moderate levels of dissent are not only useful as an error-correcting mechanism but are also a characteristic of trustworthy groups.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory factor transport drives macrophage aggregation in an in silico aneurysm inflammation model. 在硅动脉瘤炎症模型中，炎症因子运输驱动巨噬细胞聚集。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-05 DOI: 10.1098/rsif.2025.0535

Zhitian R Shi, Hadi Wiputra, Jesse W Williams, Victor H Barocas

{"title":"Inflammatory factor transport drives macrophage aggregation in an in silico aneurysm inflammation model.","authors":"Zhitian R Shi, Hadi Wiputra, Jesse W Williams, Victor H Barocas","doi":"10.1098/rsif.2025.0535","DOIUrl":"10.1098/rsif.2025.0535","url":null,"abstract":"Inflammation plays an important role in the pathological remodelling and rupture of intracranial aneurysms. One of the challenges in predicting the prognosis of intracranial aneurysms lies in the variation of the inflammatory state in aneurysm tissues from patient to patient. The connection between aneurysm biophysical environment and inflammation is largely unexplored by predictive computational models. In this study, a computational model based on a positive feedback mechanism driven by paracrine signalling between monocytes, macrophages and soluble inflammatory factors was proposed. Based on this model, three inflammatory factor transport regimes characterized by the dominance of (i) diffusion, (ii) production, or (iii) removal that drove at distinctive inflammatory dynamics were identified. A dimensionless group, production-to-transport ratio, strongly correlated with the simulated macrophage count (R2=0.97). The theoretical model in this work was simplified, but it demonstrated that inflammatory factor transport could have a profound impact on the inflammation process. This study suggests that haemodynamics may indirectly influence the state of inflammation, beyond the well-documented mechanosensory response of the vascular endothelium, by modulating the transport conditions for inflammatory factors.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myofibroblasts slow down defect recombination dynamics in mixed cell monolayers. 肌成纤维细胞减缓混合细胞单层中缺陷重组动力学。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-05 DOI: 10.1098/rsif.2026.0007

Zhaofei Zheng, Yuxin Luo, Juan Chen, Yimin Luo

{"title":"Myofibroblasts slow down defect recombination dynamics in mixed cell monolayers.","authors":"Zhaofei Zheng, Yuxin Luo, Juan Chen, Yimin Luo","doi":"10.1098/rsif.2026.0007","DOIUrl":"10.1098/rsif.2026.0007","url":null,"abstract":"Cellular organization and mechanotransduction pathways are crucial regulators of tissue morphogenesis, whereas their dysregulation contributes to pathologies. Overactive myofibroblasts are key drivers of fibrosis, yet how their presence alters collective cellular ordering remains unclear. Owing to steric interactions, elongated cells exhibit local order. Topological defects, where alignment is disrupted, have been postulated to serve as mechanical centres. In this study, we examine how incorporating slower-moving myofibroblast phenotype impacts defect relaxation in monolayers consisting of co-cultured fibroblasts and myofibroblasts. In this system, myofibroblasts act as the less active component. Increasing their fraction increases disorder strength and slows defect recombination. On microgrooved surfaces, higher myofibroblast concentrations lead to worse alignment, suggesting single-cell mechanosensing and cell-cell interactions act jointly. Furthermore, we found that myofibroblasts preferentially localize at negatively charged -12 defects, whereas fibroblasts localize at +12 defects. Consequently, the slowdown of recombination dynamics can be partially attributed to myofibroblasts' preferential association with the less mobile -12 defects, increasing local friction and impeding defect mobility. This localization may also reduce compressive stress on myofibroblasts, as indicated by immunofluorescence of a downstream mechanotransducer. This work provides insights into possible connections between topological defects and cell motility in mixed phenotype monolayers.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148673935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multi-sensor continuous-flow bioreactor for dynamic and scalable cell culture. 用于动态和可扩展细胞培养的多传感器连续流生物反应器。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-05 DOI: 10.1098/rsif.2025.0590

Matthew James, Dennis Edmondson, Jason Samson, Richard A Revia, David Wood, Candan Tamerler, Miqin Zhang

{"title":"Multi-sensor continuous-flow bioreactor for dynamic and scalable cell culture.","authors":"Matthew James, Dennis Edmondson, Jason Samson, Richard A Revia, David Wood, Candan Tamerler, Miqin Zhang","doi":"10.1098/rsif.2025.0590","DOIUrl":"10.1098/rsif.2025.0590","url":null,"abstract":"Bioreactors are essential tools in tissue engineering and advanced cell culture because they provide dynamic environments that support cellular growth, organization and tissue maturation. However, most existing systems lack integrated real-time monitoring and feedback control, limiting their reproducibility, scalability and translational relevance. Here, we report the development of a modular, continuous-flow rotational (CFR) bioreactor system equipped with multi-sensor feedback to enable real-time monitoring and control of pH, temperature, dissolved oxygen, CO2 and rotation speed. A key design feature is a swivel connector architecture that enables uninterrupted media and gas exchange during chamber rotation while maintaining sterility and preventing tubing entanglement. Constructed from off-the-shelf components with custom firmware and a Python-based interface, the system maintains stable and physiologically relevant culture conditions. Its modular design supports both macro- and microscale formats and enables multiplexed experiments. The system's versatility was demonstrated by culturing U-87 MG glioblastoma cells on chitosan scaffolds and Jurkat T cells in suspension, resulting in improved cell viability and distribution compared with static controls. These results demonstrate that the CFR platform provides a scalable, sensor-integrated culture system for applications in tissue engineering, disease modelling, drug screening and regenerative medicine.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0