Journal of The Royal Society Interface最新文献_第7页

A mathematical model to predict network growth in Physarum polycephalum as a function of extracellular matrix viscosity, measured by a novel viscometer. 用一种新型的黏度计，建立了预测多头绒泡菌细胞外基质黏度的网络生长的数学模型。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1098/rsif.2024.0720

Philipp Rosina, Martin Grube

{"title":"A mathematical model to predict network growth in Physarum polycephalum as a function of extracellular matrix viscosity, measured by a novel viscometer.","authors":"Philipp Rosina, Martin Grube","doi":"10.1098/rsif.2024.0720","DOIUrl":"10.1098/rsif.2024.0720","url":null,"abstract":"Physarum polycephalum is a slime mould that forms complex networks, making it an ideal model organism for studying network formation and adaptation. We introduce a novel viscometer capable of accurately measuring extracellular slime matrix (ECM) viscosity in small biological samples, overcoming the limitations of conventional instruments. Using this device, we measured the relative kinematic viscosity and developed continuous models to predict network size over time as a function of ECM viscosity. Our results show that increased ECM viscosity, driven by higher salt (MgCl2·6H2O) concentrations, significantly slows network expansion but does not affect the final network complexity. Fractal dimension analysis revealed that network complexity converged to a similar value across all viscosity conditions during the equilibrium state. The models demonstrated strong predictive power, with a mean squared error below 0.4%, closely aligning with experimental data. These findings highlight the critical role of ECM viscosity in influencing network expansion while demonstrating that complexity remains stable across varying conditions. This study advances our understanding of the physical parameters shaping P. polycephalum networks and provides a foundation for exploring network dynamics in other adaptive systems. These insights offer new tools for research in biological systems where sample material is limited.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 224","pages":"20240720"},"PeriodicalIF":3.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Parameter selection and optimization of a computational network model of blood flow in single-ventricle patients. 单心室患者血流计算网络模型的参数选择与优化。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-27 DOI: 10.1098/rsif.2024.0663

Alyssa M Taylor-LaPole, L Mihaela Paun, Dan Lior, Justin D Weigand, Charles Puelz, Mette S Olufsen

{"title":"Parameter selection and optimization of a computational network model of blood flow in single-ventricle patients.","authors":"Alyssa M Taylor-LaPole, L Mihaela Paun, Dan Lior, Justin D Weigand, Charles Puelz, Mette S Olufsen","doi":"10.1098/rsif.2024.0663","DOIUrl":"10.1098/rsif.2024.0663","url":null,"abstract":"Hypoplastic left heart syndrome (HLHS) is a congenital heart disease responsible for 23% of infant cardiac deaths each year in the United States. HLHS patients are born with an underdeveloped left heart, requiring several surgeries to reconstruct the aorta and create a single-ventricle circuit known as the Fontan circulation. While survival into early adulthood is becoming more common, Fontan patients often have a reduced cardiac output, putting them at risk for a multitude of complications. These patients are monitored using chest and neck magnetic resonance imaging (MRI), but their scans do not capture energy loss, pressure, wave intensity or haemodynamics beyond the imaged region. This study develops a framework for predicting these missing features by combining imaging data and computational fluid dynamics (CFD) models. Predicted features from models of HLHS patients are compared with those from control patients with a double outlet right ventricle (DORV). We infer patient-specific parameters through the proposed framework. In the calibrated model, we predict pressure, flow, wave intensity (WI) and wall shear stress (WSS). Results reveal that HLHS patients have lower compliance than DORV patients, resulting in lower WSS and higher WI in the ascending aorta and increased WSS and decreased WI in the descending aorta.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240663"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The cultural transmission of Ongagawa style pottery in the prehistoric Japan: quantitative analysis on three-dimensional data of archaeological pottery in the early Yayoi period. 日本史前女川式陶器的文化传播：弥生早期考古陶器三维数据的定量分析。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI: 10.1098/rsif.2024.0889

Koji Noshita, Tomomi Nakagawa, Akihiro Kaneda, Kohei Tamura, Hisashi Nakao

引用次数: 0

Compartmental structure in the secondary lymphoid tissue can slow down in vivo HIV-1 evolution in the presence of strong CTL responses. 二级淋巴组织的区室结构可以在强烈的CTL反应下减缓体内HIV-1的进化。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-26 DOI: 10.1098/rsif.2024.0468

Wen-Jian Chung, Dominik Wodarz

{"title":"Compartmental structure in the secondary lymphoid tissue can slow down in vivo HIV-1 evolution in the presence of strong CTL responses.","authors":"Wen-Jian Chung, Dominik Wodarz","doi":"10.1098/rsif.2024.0468","DOIUrl":"10.1098/rsif.2024.0468","url":null,"abstract":"Human immunodeficiency virus (HIV-1) replicates in the secondary lymphoid tissues, which are characterized by complex compartmental structures. While cytotoxic T lymphocytes (CTL) readily access infected cells in the extrafollicular compartments, they do not home to follicular compartments, which thus represent an immune-privileged site. Using mathematical models, previous work has shown that this compartmental tissue structure can delay the emergence of CTL escape mutants. Here, we show computationally that the compartmental structure can have an impact on the evolution of advantageous mutants that are not related to CTL recognition: (i) compartmental structure can influence the fixation probability of an advantageous mutant, with weakened selection occurring if CTL responses are of intermediate strength; (ii) compartmental structure is predicted to reduce the rate of mutant generation, which becomes more pronounced for stronger CTL responses; and (iii) compartmental structure is predicted to slow down the overall rate of mutant invasion, with the effect becoming more pronounced for stronger CTL responses. Altogether, this work shows that in vivo virus evolution proceeds slower in models with compartmental structure compared with models that assume equivalent virus load in the absence of compartmental structure, especially for strong CTL-mediated virus control. This has implications for understanding the rate of disease progression.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240468"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angular distribution of fractal temporal correlations supports adaptive responses to wobble board instability. 分形时间相关性的角分布支持对摇板失稳的自适应响应。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-05 DOI: 10.1098/rsif.2024.0664

Brian Schlattmann, Ken Kiyono, Damian G Kelty-Stephen, Madhur Mangalam

{"title":"Angular distribution of fractal temporal correlations supports adaptive responses to wobble board instability.","authors":"Brian Schlattmann, Ken Kiyono, Damian G Kelty-Stephen, Madhur Mangalam","doi":"10.1098/rsif.2024.0664","DOIUrl":"10.1098/rsif.2024.0664","url":null,"abstract":"Contemporary dynamical models of human postural control propose an intermittent controller regulating the postural centre of pressure (CoP) about a stable saddle-shaped manifold along anatomical anteroposterior (AP) and mediolateral (ML) axes, releasing CoP in an outwards spiral when inactive. Experimental manipulations can evoke this saddle-type topology in fractal temporal correlations along the AP axis and reducing correlations along the ML axis. However, true effects of task demands may often manifest within angular space between anatomical AP and ML axes-a space not typically modelled explicitly. We tested how instability and attentional load influence postural control across the full angular range of fractal variability along the two-dimensional (2D) support surface. Forty-eight healthy young adults performed a suprapostural Trail Making Test (TMT) while standing on a wobble board, inducing continuous perturbations along the ML axis. Stable, quiet standing exhibited classic saddle-like topology, with stronger fractal temporal correlations in CoP displacements along AP axes. The attentional demand of the TMT did not affect angular variation or strength of fractal temporal correlations across the 2Dsupport surface. However, maintaining upright balance on the wobble board reshaped and reoriented the angular distribution of fractal temporal correlations, accentuating saddle-like angular variation and rotating the strongest fractal temporal correlations predominantly along the ML axis. Stabilizing posture in the face of wobble board instability prompted the saddle-type angular distribution of fractal temporal correlations. These findings challenge the traditional dependence of postural control theories exclusively on external force-plate axes and underscore the significance of multifractality in defining control parameters that govern postural stability across the full angular range of the 2D support surface.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240664"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An integrated airborne transmission risk assessment model for respiratory viruses: short- and long-range contributions. 呼吸道病毒的综合空气传播风险评估模型：短期和长期贡献。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-26 DOI: 10.1098/rsif.2024.0740

Andre Henriques, Wei Jia, Luis Aleixo, Nicolas Mounet, Luca Fontana, Alice Simniceanu, James Devine, Philip Elson, Gabriella Azzopardi, Markus Rognlien, Marco Andreini, Nicola Tarocco, Olivia Keiser, Yuguo Li, Julian W Tang

{"title":"An integrated airborne transmission risk assessment model for respiratory viruses: short- and long-range contributions.","authors":"Andre Henriques, Wei Jia, Luis Aleixo, Nicolas Mounet, Luca Fontana, Alice Simniceanu, James Devine, Philip Elson, Gabriella Azzopardi, Markus Rognlien, Marco Andreini, Nicola Tarocco, Olivia Keiser, Yuguo Li, Julian W Tang","doi":"10.1098/rsif.2024.0740","DOIUrl":"10.1098/rsif.2024.0740","url":null,"abstract":"This study presents an advanced airborne transmission risk assessment model that integrates both short- and long-range routes in the spread of respiratory viruses, building upon the CERN Airborne Model for Indoor Risk Assessment (CAiMIRA) and aligned with the new World Health Organization (WHO) terminology. Thanks to a two-stage exhaled jet approach, the model accurately simulates short-range exposures, thereby improving infection risk predictions across diverse indoor settings. Key findings reveal that in patient wards, the short-range viral dose is 10-fold higher than the long-range component, highlighting the critical role of close proximity interactions. Implementation of FFP2 respirators resulted in a remarkable 13-fold reduction in viral dose, underscoring the effectiveness of personal protective equipment (PPE). Additionally, the model demonstrated that an 8 h exposure in a poorly ventilated office can equate to the risk of a 15 min face-to-face, mask-less interaction, emphasizing the importance of physical distancing and source control. We also found in high-risk or low-occupancy settings, that secondary transmission is driven more by overall epidemic trends than by the presence of individual superspreaders. Monte Carlo simulations across various scenarios, including classrooms and offices, validate the model's robustness in optimizing infection prevention strategies. These findings support targeted interventions for short- and long-range exposure to reduce airborne transmission.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240740"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11858786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143501877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Jointed tails enhance control of three-dimensional body rotation. 关节尾巴增强了对三维身体旋转的控制。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-05 DOI: 10.1098/rsif.2024.0355

Xun Fu, Bohao Zhang, Ceri J Weber, Kimberly L Cooper, Ram Vasudevan, Talia Y Moore

{"title":"Jointed tails enhance control of three-dimensional body rotation.","authors":"Xun Fu, Bohao Zhang, Ceri J Weber, Kimberly L Cooper, Ram Vasudevan, Talia Y Moore","doi":"10.1098/rsif.2024.0355","DOIUrl":"10.1098/rsif.2024.0355","url":null,"abstract":"Tails used as inertial appendages induce body rotations of animals and robots-a phenomenon that is governed largely by the ratio of the body and tail moments of inertia. However, vertebrate tails have more degrees of freedom (e.g. number of joints and rotational axes) than most current theoretical models and robotic tails. To understand how morphology affects inertial appendage function, we developed an optimization-based approach that finds the maximally effective tail trajectory and measures error from a target trajectory. For tails of equal total length and mass, increasing the number of equal-length joints increased the complexity of maximally effective tail motions. When we optimized the relative lengths of tail bones while keeping the total tail length, mass and number of joints the same, this optimization-based approach found that the lengths matched the pattern found in the tail bones of mammals specialized for inertial manoeuvring. In both experiments, adding joints enhanced the performance of the inertial appendage, but with diminishing returns, largely due to the total control effort constraint. This optimization-based simulation can compare the maximum performance of diverse inertial appendages that dynamically vary in a moment of inertia in three-dimensional space, predict inertial capabilities from skeletal data and inform the design of robotic inertial appendages.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240355"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11793978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Habitat fragmentation enhances microbial collective defence. 栖息地破碎化增强了微生物的集体防御。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1098/rsif.2024.0611

Nia Verdon, Ofelia Popescu, Simon Titmuss, Rosalind J Allen

{"title":"Habitat fragmentation enhances microbial collective defence.","authors":"Nia Verdon, Ofelia Popescu, Simon Titmuss, Rosalind J Allen","doi":"10.1098/rsif.2024.0611","DOIUrl":"10.1098/rsif.2024.0611","url":null,"abstract":"Microbes often inhabit complex, spatially partitioned environments such as host tissue or soil, but the effects of habitat fragmentation on microbial ecology and infection dynamics are poorly understood. Here, we investigate how habitat fragmentation impacts a prevalent microbial collective defence mechanism: enzymatic degradation of an environmental toxin. Using a theoretical model, we predict that habitat fragmentation can strongly enhance the collective benefits of enzymatic toxin degradation. For the example of [Formula: see text]-lactamase-producing bacteria that mount a collective defence by degrading a [Formula: see text]-lactam antibiotic, we find that realistic levels of habitat fragmentation can allow a population to survive antibiotic doses that greatly exceed those required to kill a non-fragmented population. This 'habitat-fragmentation rescue' is a stochastic effect that originates from variation in bacterial density among different subpopulations and demographic noise. We also study the contrasting case of collective enzymatic foraging, where enzyme activity releases nutrients from the environment; here we find that increasing habitat fragmentation decreases the lag time for population growth but does not change the ecological outcome. Taken together, this work predicts that stochastic effects arising from habitat fragmentation can greatly enhance the effectiveness of microbial collective defence via enzymatic toxin degradation.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240611"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local postural changes elicit extensive and diverse skin stretch around joints, on the trunk and the face. 局部体位变化引起关节周围、躯干和面部广泛多样的皮肤伸展。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-19 DOI: 10.1098/rsif.2024.0794

Mia Rupani, Luke D Cleland, Hannes P Saal

{"title":"Local postural changes elicit extensive and diverse skin stretch around joints, on the trunk and the face.","authors":"Mia Rupani, Luke D Cleland, Hannes P Saal","doi":"10.1098/rsif.2024.0794","DOIUrl":"10.1098/rsif.2024.0794","url":null,"abstract":"Skin stretch, induced by bodily movements, offers a potential source of information about the conformation of the body that can be transmitted to the brain via stretch-sensitive mechanoreceptive neurons. While previous studies have primarily focused on skin stretch directly at joints, here we investigate the extent and complexity of natural skin stretch across various body regions, including the face and trunk. We used a quad-camera set-up to image large ink-based speckle patterns stamped on participants' skin and calculated the resulting stretch patterns on a millimetre scale during a range of natural poses. We observed that skin stretch associated with joint movement extends far beyond the joint itself, with knee flexion inducing stretch on the upper thigh. Large and uniform stretch patterns were found across the trunk, covering considerable portions of the skin. The face exhibited highly complex and non-uniform stretch patterns, potentially contributing to our capacity to control fine facial movements in the absence of traditional proprioceptors. Importantly, all regions demonstrated skin stretch in excess of mechanoreceptive thresholds, suggesting that behaviourally relevant skin stretch can occur anywhere on the body. These signals might provide the brain with valuable information about body state and conformation, potentially supplementing or even surpassing the capabilities of traditional proprioception.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240794"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications. 模型引导基因电路设计工程遗传稳定的细胞群体在不同的应用。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-02-01 Epub Date: 2025-02-12 DOI: 10.1098/rsif.2024.0602

Kirill Sechkar, Harrison Steel

{"title":"Model-guided gene circuit design for engineering genetically stable cell populations in diverse applications.","authors":"Kirill Sechkar, Harrison Steel","doi":"10.1098/rsif.2024.0602","DOIUrl":"10.1098/rsif.2024.0602","url":null,"abstract":"Maintaining engineered cell populations' genetic stability is a key challenge in synthetic biology. Synthetic genetic constructs compete with a host cell's native genes for expression resources, burdening the cell and impairing its growth. This creates a selective pressure favouring mutations which alleviate this growth defect by removing synthetic gene expression. Non-functional mutants thus spread in cell populations, eventually making them lose engineered functions. Past work has attempted to limit mutation spread by coupling synthetic gene expression to survival. However, these approaches are highly context-dependent and must be tailor-made for each particular synthetic gene circuit to be retained. By contrast, we develop and analyse a biomolecular controller which depresses mutant cell growth independently of the mutated synthetic gene's identity. Modelling shows how our design can be deployed alongside various synthetic circuits without any re-engineering of its genetic components, outperforming extant gene-specific mutation spread mitigation strategies. Our controller's performance is evaluated using a novel simulation approach which leverages resource-aware cell modelling to directly link a circuit's design parameters to its population-level behaviour. Our design's adaptability promises to mitigate mutation spread in an expanded range of applications, while our analyses provide a blueprint for using resource-aware cell models in circuit design.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 223","pages":"20240602"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11813585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0