Journal of The Royal Society Interface最新文献_第6页

Climate and dengue synchronization in southern Brazil: a municipal analysis with cross-state validation. 巴西南部的气候和登革热同步：一项具有跨州验证的市政分析。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-26 DOI: 10.1098/rsif.2026.0438

Enrique C Gabrick, Antonio M Batista, Iberê L Caldas, Jürgen Kurths, Maíra Aguiar

{"title":"Climate and dengue synchronization in southern Brazil: a municipal analysis with cross-state validation.","authors":"Enrique C Gabrick, Antonio M Batista, Iberê L Caldas, Jürgen Kurths, Maíra Aguiar","doi":"10.1098/rsif.2026.0438","DOIUrl":"10.1098/rsif.2026.0438","url":null,"abstract":"Dengue transmission is rapidly expanding beyond its historical tropical range, raising concerns about how climate change may alter the collective dynamics of epidemics. While most studies focus on transmission risk, much less is known about how climate affects the synchronization of outbreaks. In this work, we investigate dengue synchronization using epidemiological and climate data from 74 municipalities in the state of Paraná (southern Brazil) between 2010 and 2024. We quantify outbreak coherence using the event synchronization (ES) method. Our results reveal a transition from a low-transmission regime to a high-transmission regime accompanied by a marked increase in synchronization across cities. We also show that climate anomalies increase the number of permissive days for dengue transmission. Our results suggest that such days are significantly associated with outbreak synchronization. We identify a two-stage climate mechanism: conducive climatic conditions first reduce the probability of asynchronous states and coincide with the emergence of synchronized outbreaks, and subsequently sustain higher synchronization levels. Extending the analysis through comparative analyses in Ceará and Minas Gerais, we uncover that climate consistently amplifies synchronization, although its role in the onset of synchronization depends on regional climatic regimes. These findings highlight climate-driven synchronization as an emerging feature shaping dengue dynamics.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal morphological characterization of the femoro-tibial joint of the black vine weevil (Otiorhynchus sulcatus). 黑藤象（Otiorhynchus sulcatus）股胫关节的多模态形态学特征。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-26 DOI: 10.1098/rsif.2026.0376

Cornelia Friederike Pichler, Rafaela Debastiani, Matthias Mail, Jenny Hein, Elias Hamann, Tilo Baumbach, Hendrik Hölscher, Thomas van de Kamp

引用次数: 0

From bird viremia to bird surveillance: identifiability in a multi-scale vector-borne model of Usutu virus infection. 从鸟类病毒血症到鸟类监测：Usutu病毒感染的多尺度媒介传播模型的可识别性。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-26 DOI: 10.1098/rsif.2026.0174

Necibe Tuncer, Yuganthi Liyanage, Quiyana Murphy, Rachel Pesinger, Nisha Duggal, Stanca M Ciupe

{"title":"From bird viremia to bird surveillance: identifiability in a multi-scale vector-borne model of Usutu virus infection.","authors":"Necibe Tuncer, Yuganthi Liyanage, Quiyana Murphy, Rachel Pesinger, Nisha Duggal, Stanca M Ciupe","doi":"10.1098/rsif.2026.0174","DOIUrl":"10.1098/rsif.2026.0174","url":null,"abstract":"Usutu virus is an emerging mosquito-borne flavivirus, maintained through an enzootic cycle involving wild birds and mosquitoes, with occasional spillover to humans. Understanding how interactions across these biological scales shape transmission dynamics is essential for predicting outbreaks and improving surveillance strategies. In this study, we developed a multi-scale vector-borne model of Usutu virus infection that links within-host viral kinetics in birds, the per-bite probability of mosquito infection and population-level mosquito-bird transmission dynamics. Model parameters were validated using two laboratory datasets collected under an optimally designed experimental framework and one surveillance dataset from wild bird populations. We developed new structural and practical identifiability methods and used them to evaluate parameter robustness under varying levels of measurement noise. We found that simultaneous multi-scale fitting to integrated datasets improved parameter identifiability and robustness. These results highlight the importance of combining micro-scale and macro-scale data to enhance the predictive reliability of vector-borne disease models and demonstrate the broader utility of multi-scale modelling frameworks for understanding the transmission dynamics of emerging viruses.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viral transport in evaporating sessile model respiratory droplets. 病毒在蒸发无根模型呼吸道飞沫中的转运。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-19 DOI: 10.1098/rsif.2025.1153

Javier Martínez Puig, Carlos de la Torre, Carolina Arbesu Nieto, Pepijn I Hoekstra, Fernando Usera Mena, Beatriz Martín-Jouve, Arancha de la Encina, Marta Bartolomé, Marta Sanz, Fernando Almazán, Ana Oña, Alvaro Marin, Javier Rodríguez-Rodríguez

{"title":"Viral transport in evaporating sessile model respiratory droplets.","authors":"Javier Martínez Puig, Carlos de la Torre, Carolina Arbesu Nieto, Pepijn I Hoekstra, Fernando Usera Mena, Beatriz Martín-Jouve, Arancha de la Encina, Marta Bartolomé, Marta Sanz, Fernando Almazán, Ana Oña, Alvaro Marin, Javier Rodríguez-Rodríguez","doi":"10.1098/rsif.2025.1153","DOIUrl":"10.1098/rsif.2025.1153","url":null,"abstract":"Viral particles, or virions, may remain infectious in the dry residue of respiratory droplets for times as long as hours. This is counterintuitive, since salt concentration increases dramatically as the drop's water evaporates, making the drop a harsh environment for virions. It has been hypothesized that the drop components (mainly salt and the glycoprotein mucin) segregate during the evaporation process, with virions being transported away from salt deposits. This would protect them from the salt's damaging effects. Thus, understanding where virions reside in a drop residue is essential to disentangle the physico-chemical mechanisms that drive their inactivation. However, determining the virion location in an environment as heterogeneous and complex as a respiratory drop is challenging. Here, we show experimentally that virions in a drop's dry residue are found mainly forming aggregates in protein-rich regions, outside salt crystals. The mechanism yielding the observed viral spatial distribution can be found in the internal flow phenomena within the droplet, which are described using numerical simulations. We anticipate our results to be relevant to explain the discrepancies in the infectivity decay rates measured in respiratory drops in previously reported studies.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The chemical composition of narwhal tusk and tooth is impacted by geographical locality. 独角鲸的长牙和牙齿的化学成分受地理位置的影响。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-19 DOI: 10.1098/rsif.2026.0027

Peter A S Vibe, Eva Garde, Martin Bondesgaard, Carsten Pedersen, Mads Peter Heide-Jøergensen, Henrik Birkedal

{"title":"The chemical composition of narwhal tusk and tooth is impacted by geographical locality.","authors":"Peter A S Vibe, Eva Garde, Martin Bondesgaard, Carsten Pedersen, Mads Peter Heide-Jøergensen, Henrik Birkedal","doi":"10.1098/rsif.2026.0027","DOIUrl":"10.1098/rsif.2026.0027","url":null,"abstract":"The possible relationship between diet and geographical locality is important for understanding the putative effects of climate change on animal behaviour and survival. Narwhals have two maxillary teeth, one of which may become a tusk. In these teeth, various chemical elements are incorporated and stored at the time of tooth formation. Here, we use inductively coupled plasma optical emission spectroscopy to investigate 12 chemical elements in tooth powder drilled from a total of 197 narwhal teeth from both sexes, tusks, embedded teeth, dentin, cementum and different geographical localities around Greenland. Additionally, the spatial distribution of Sr and Zn was mapped on a slice of tusk using X-ray fluorescence. Quantifications of Ca and P showed a mean degree of mineralization of 0.565 g g-1 and their relationship enabled the determination of the presence of approximately 1 wt% non-biomineral-associated P, which must be associated with biomolecules. While several differences were found across sampling parameters, no significant differences were found between males and females for any elements. Finally, the concentration of Cl, Ba, K and S depended on geographical locality; geographical locality was the only significant factor for Cl. These differences could potentially be linked to the circulation of freshwater from melting ice at and around Greenland.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks. 从化学振荡器到生物同步：研究心肌细胞网络信号协调的可编程反应-扩散模型。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-19 DOI: 10.1098/rsif.2026.0095

Zhaotong Chu, Yidi Zhang, Mengya Liu, Huiying Gong, Zefu Wang, Zhanli Yang, Ming-Zhu Sun, Xin Zhao, Shan Guo, Yaowei Liu

{"title":"From chemical oscillators to biological synchrony: a programmable reaction-diffusion model for studying signal coordination in cardiomyocyte networks.","authors":"Zhaotong Chu, Yidi Zhang, Mengya Liu, Huiying Gong, Zefu Wang, Zhanli Yang, Ming-Zhu Sun, Xin Zhao, Shan Guo, Yaowei Liu","doi":"10.1098/rsif.2026.0095","DOIUrl":"10.1098/rsif.2026.0095","url":null,"abstract":"The self-organization of asynchronous rhythms into synchronized beating in in vitro cardiomyocyte networks is a fundamental problem in systems biology research. Inspired by the dynamics of chemical oscillators, this paper presents a programmable model framework based on a discretized Belousov-Zhabotinsky reaction-diffusion system to study signal propagation and synchronization in cardiomyocyte networks. We propose a hybrid discrete-continuous geometry in which active excitable units (simulating cells) are embedded in a passive diffusive medium, with the dynamics of each unit governed by the Rovinsky-Zhabotinsky equations. Unlike conventional continuous media models, the present framework represents each cell as an independently programmable discrete unit, thereby explicitly capturing the discreteness and cell-to-cell variability inherent in in vitro cardiomyocyte networks. We systematically compare model simulations with in vitro experiments on neonatal rat cardiomyocyte networks using calcium imaging and mechanical stimulation. The framework reproduces multi-scale dynamical features: (i) intracellular excitation-propagation-recovery cycles, (ii) topology-dependent signal transmission in both regular and irregular networks, and (iii) the self-organized transition from cell-to-cell synchronization to global population synchronization. These qualitative agreements demonstrate that a simplified, programmable reaction-diffusion framework can capture the signalling dynamics of cardiomyocyte excitable systems, offering a new perspective for investigating signal coordination in cardiomyocyte networks.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Joint economic and epidemiological modelling of alternative pandemic response strategies. 其他大流行应对战略的联合经济和流行病学建模。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-19 DOI: 10.1098/rsif.2026.0098

Michael John Plank, Megan Sushames, Timothy Fisher-Taylor, Amin Afshari, Robin N Thompson, Amy Hurford, Shaun Hendy

{"title":"Joint economic and epidemiological modelling of alternative pandemic response strategies.","authors":"Michael John Plank, Megan Sushames, Timothy Fisher-Taylor, Amin Afshari, Robin N Thompson, Amy Hurford, Shaun Hendy","doi":"10.1098/rsif.2026.0098","DOIUrl":"10.1098/rsif.2026.0098","url":null,"abstract":"In an emerging pandemic, policymakers need to make decisions with limited information and require trade-offs between the health impact of the pandemic and the economic costs of the response. Most mathematical models have focused on direct health impacts, neglecting the economic costs of control measures. Here, we introduce a framework that captures both health and economic costs and compare the expected aggregate costs of alternative strategies across a range of epidemiological and economic parameters. We find that for diseases with low severity, mitigation tends to be the most cost-effective option. For more severe diseases, suppression tends to be most cost-effective if the basic reproduction number R0 is relatively low, while elimination tends to be more cost-effective if R0 is high. We use the example of New Zealand's response to the COVID-19 pandemic in 2020 to anchor our framework to a real-world case study. We find that parameter estimates for COVID-19 in New Zealand put it close to or above the threshold at which elimination becomes more cost-effective than mitigation. We conclude that our proposed framework holds promise as a decision-support tool for pandemic threats, with further work needed to account for population heterogeneity and other factors relevant to decision-making.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical limits shape the eccentric form of rose prickles. 机械限制形成了玫瑰刺的偏心形状。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2025.1300

Sabrina Gennis, Matteo Pezzulla, Kaare H Jensen

引用次数: 0

Pollutant-induced changes in fish pigmentation and spatial patterns. 污染物引起的鱼类色素沉着和空间格局的变化。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2026.0065

Pranali Roy Chowdhury, Tian Xu Wang, Abbey MacDonald, Keith Tierney, Hao Wang

{"title":"Pollutant-induced changes in fish pigmentation and spatial patterns.","authors":"Pranali Roy Chowdhury, Tian Xu Wang, Abbey MacDonald, Keith Tierney, Hao Wang","doi":"10.1098/rsif.2026.0065","DOIUrl":"10.1098/rsif.2026.0065","url":null,"abstract":"Pigmentation abnormalities, ranging from hypo- to hyperpigmentation, can serve as biomarkers of developmental disruption in fish exposed to environmental contaminants. However, the mechanistic pathways underlying these alterations remain poorly understood. Studies have shown that pattern formation in fish development requires specific pigment cell interactions. Motivated by experimental observations of pigmentation alterations following contaminant exposure, we investigate how pollutants influence pigment cell self-organization using a continuum reaction-diffusion-advection framework. The model incorporates non-local Morse-type kernels to describe short- and long-range interactions among melanophores and xanthophores. Our results show that perturbations to the strengths of adhesion or repulsion can drive transitions between stripes, spots and mixed patterns, reproducing phenotypes characteristic of fish pigmentation mutants. In particular, homotypic interactions are sensitive to contamination, leading to pronounced changes in melanophore density and resulting pigmentation patterns. Time-dependent simulations indicate that pigment changes from early short-term contaminant exposure may be recoverable, whereas prolonged exposure can lead to sustained pigment loss. In a growing fish, contaminant-induced changes in cell-cell interactions directly influence stripe formation rate, stripe number and pigmentation levels. Overall, our study provides insight into the mechanistic link between experimentally observed pigmentation alterations and the changes in spatial patterns of adult fish.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"23 241","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reviewers in 2025. 2025年的评论者。

IF 3.4 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2026-08-12 DOI: 10.1098/rsif.2026.0486

Richard Cogdell

引用次数: 0