Journal of The Royal Society Interface最新文献

{"title":"Modelling the mechanisms of antibody mixtures in viral infections: the cases of sequential homologous and heterologous dengue infections.","authors":"Charlotte Dugourd-Camus, Claudia P Ferreira, Mostafa Adimy","doi":"10.1098/rsif.2024.0182","DOIUrl":"10.1098/rsif.2024.0182","url":null,"abstract":"<p><p>Antibodies play an essential role in the immune response to viral infections, vaccination or antibody therapy. Nevertheless, they can be either protective or harmful during the immune response. Moreover, competition or cooperation between mixed antibodies can enhance or reduce this protective or harmful effect. Using the laws of chemical reactions, we propose a new approach to modelling the antigen-antibody complex activity. The resulting expression covers not only purely competitive or purely independent binding but also synergistic binding which, depending on the antibodies, can promote either neutralization or enhancement of viral activity. We then integrate this expression of viral activity in a within-host model and investigate the existence of steady-states and their asymptotic stability. We complete our study with numerical simulations to illustrate different scenarios: firstly, where both antibodies are neutralizing and secondly, where one antibody is neutralizing and the other enhancing. The results indicate that efficient viral neutralization is associated with purely independent antibody binding, whereas strong viral activity enhancement is expected in the case of purely competitive antibody binding. Finally, data collected during a secondary dengue infection were used to validate the model. The dataset includes sequential measurements of virus and antibody titres during viremia in patients. Data fitting shows that the two antibodies are in strong competition, as the synergistic binding is low. This contributes to the high levels of virus titres and may explain the antibody-dependent enhancement phenomenon. Besides, the mortality of infected cells is almost twice as high as that of susceptible cells, and the heterogeneity of viral kinetics in patients is associated with variability in antibody responses between individuals. Other applications of the model may be considered, such as the efficacy of vaccines and antibody-based therapies.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240182"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term tracing of individual human neural cells using multiphoton microscopy and photoconvertible polymer capsules.","authors":"Ivan V Smirnov, Veronika S Usatova, Mikhail A Berestovoy, Andrei B Fedotov, Aleksandr A Lanin, Vsevolod V Belousov, Gleb B Sukhorukov","doi":"10.1098/rsif.2024.0497","DOIUrl":"10.1098/rsif.2024.0497","url":null,"abstract":"<p><p>The study of human neural cells, their behaviour and migration are important areas of research in the biomedical field, particularly for potential therapeutic applications. The safety of using neural cells in therapy is still a concern due to a lack of information on long-term changes that may occur. While current methods of cell tracing explore gene manipulations, we elaborate approaches to cell marking with no genetic interference. In this study, we present a novel method for labelling and tracking neural cells using cell-impregnatable photoconvertible polyelectrolyte microcapsules. These capsules demonstrated low cytotoxicity with no effect on the differentiation ability of the neural cells, maintained a high level of fluorescent signal and ability for tracing individual neural cells for over 7 days. The capsules modified with rhodamine- and fluorescein-based dyes were demonstrated to undergo photoconversion by both one- and two-photon lasers while being internalized by neural cells. The finding gives the possibility to select individual capsules inside multicellular structures like spheroids and tissues and alternate their fluorescent appearance. Thus, we can track individual cell paths in complex systems. This new method offers a promising alternative for studying neural cells' long-term behaviour and migration in complex systems such as three-dimensional cellular populations.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240497"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geometric constraint of mechanosensing by modification of hydrogel thickness prevents stiffness-induced differentiation in bone marrow stromal cells.","authors":"Maria L Hernandez-Miranda, Dichu Xu, Aya A Ben Issa, David A Johnston, Martin Browne, Richard B Cook, Bram G Sengers, Nicholas Evans","doi":"10.1098/rsif.2024.0485","DOIUrl":"10.1098/rsif.2024.0485","url":null,"abstract":"<p><p>Extracellular matrix (ECM) stiffness is fundamental in cell division, movement and differentiation. The stiffness that cells sense is determined not only by the elastic modulus of the ECM material but also by ECM geometry and cell density. We hypothesized that these factors would influence cell traction-induced matrix deformations and cellular differentiation in bone marrow stromal cells (BMSCs). To achieve this, we cultivated BMSCs on polyacrylamide hydrogels that varied in elastic modulus and geometry and measured cell spreading, cell-imparted matrix deformations and differentiation. At low cell density BMSCs spread to a greater extent on stiff compared with soft hydrogels, or on thin compared with thick hydrogels. Cell-imparted matrix deformations were greater on soft compared with stiff hydrogels or thick compared with thin hydrogels. There were no significant differences in osteogenic differentiation relative to hydrogel elastic modulus and thickness. However, increased cell density and/or prolonged culture significantly reduced matrix deformations on soft hydrogels to levels similar to those on stiff substrates. This suggests that at high cell densities cell traction-induced matrix displacements are reduced by both neighbouring cells and the constraint imposed by an underlying stiff support. This may explain observations of the lack of difference in osteogenic differentiation as a function of stiffness.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240485"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtle frequency matching reveals resonant phenomenon in the flight of Odonata.","authors":"C Aracheloff, R Garrouste, A Nel, R Godoy-Diana, B Thiria","doi":"10.1098/rsif.2024.0401","DOIUrl":"https://doi.org/10.1098/rsif.2024.0401","url":null,"abstract":"<p><p>In this work, we investigate the connection between the flight flapping frequency and the intrinsic wing properties in Odonata (dragonflies and damselflies). For such large flying insect species, it has been noted that the wingbeat frequency is significantly lower than the structural resonance of the wing itself. However, the structural resonance mechanism is often evoked in the literature for flying and swimming animals as a means to increase locomotion performance. Here, we show that the flight of Odonata is based on a nonlinear mechanism that strongly depends on the wingbeat amplitude. For large flapping amplitudes (as observed in natural flight), the resonant frequency of the wings decreases with respect to its value at low amplitudes to eventually match the wingbeat frequency used in flight. By means of this nonlinear resonance, Odonata keep a strong wing stiffness while benefiting from a passive energy-saving mechanism based on the dynamic softening of the wing.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240401"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A computational approach to selective attention in embodied approaches to cognitive archaeology.","authors":"Axel Constant, Laura Desirèe Di Paolo, Avel Guénin-Carlut, Luis M Martinez, Felipe Criado-Boado, Johannes Müeller, Andy Clark","doi":"10.1098/rsif.2024.0508","DOIUrl":"10.1098/rsif.2024.0508","url":null,"abstract":"<p><p>This article proposes a novel computational approach to embodied approaches in cognitive archaeology called computational cognitive archaeology (CCA). We argue that cognitive archaeology, understood as the study of the human mind based on archaeological findings such as artefacts and material remains excavated and interpreted in the present, can benefit from the integration of novel methods in computational neuroscience interested in modelling the way the brain, the body and the environment are coupled and parameterized to allow for adaptive behaviour. We discuss the kind of tasks that CCA may engage in with a narrative example of how one can model the cumulative cultural evolution of the material and cognitive components of technologies, focusing on the case of knapping technology. This article thus provides a novel theoretical framework to formalize research in cognitive archaeology using recent developments in computational neuroscience.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240508"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why the Fermi paradox may not be well explained by Wong and Bartlett's theory of civilization collapse. A Comment on: 'Asymptotic burnout and homeostatic awakening: a possible solution to the Fermi paradox?' (2022) by Wong and Bartlett.","authors":"Chris J Jackson, Christian Criado-Perez","doi":"10.1098/rsif.2024.0140","DOIUrl":"10.1098/rsif.2024.0140","url":null,"abstract":"<p><p>Wong and Bartlett explain the Fermi paradox by arguing that neither human nor extra-terrestrial civilizations can escape the time window singularity which, they claim, results from the way in which social characteristics of civilizations follow super-linear growth curves of cities. We question if data at the city level necessarily can lead to conclusions at the civilization level. More specifically, we suggest ways in which learnings from research, foresight, diversity and effective future government might act outside of their model to regulate super-linear growth curves of civilizations, and thus substantively increase the likelihood of civilizations progressing towards higher levels of the Kardashev scale. Moreover, we believe their claimed history of the collapse of terrestrial societies used to evidence their model is difficult to justify. Overall, we cast reasonable doubt on the ability of their proposed model to satisfactorily explain the Fermi paradox.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240140"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New lessons from biology for economics and business: a systems approach to non-market environments.","authors":"YunHee Lee, Colin Mayer, Dennis Snower, Denis Noble","doi":"10.1098/rsif.2024.0457","DOIUrl":"10.1098/rsif.2024.0457","url":null,"abstract":"<p><p>Drawing on recent advances in biology, this paper describes a systems approach, 'Systems Public Affairs' (SPA), to integrate non-market strategies in corporate purposes and strategies. Just as the environment of organisms affects and is affected by their development and evolution, so individuals and businesses adjust to and can shape their non-market environment, which we define as 'a historically formed national and social sphere, including laws, regulations, and policies, which supports, maintains and restrains the operation and preservation of markets'. The paper uses cases from South Korea to illustrate this approach. Emergent ideas in biology have great relevance for micro-foundations of business. Traditionally, economic activities are outcomes of individualistic decision-makers, each promoting their distinct objectives within economic markets. In the SPA approach, decision makers in the domains of business, policy and civil society collaborate in shaping non-market environments to align business objectives with public interest. This requires agency to rise to higher levels than that of businesses, policymakers and civil society through collaboration and experimentation in the presence of stochasticity and radical uncertainty. Analogous to the advancement of organism evolution through emergence of nervous systems and learning, so alignment of organizations with their non-market environments accelerates economic and social development.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240457"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncertainties in exposure predictions arising from point measurements of carbon dioxide in classroom environments.","authors":"Carolanne V M Vouriot, Maarten van Reeuwijk, Henry C Burridge","doi":"10.1098/rsif.2024.0270","DOIUrl":"https://doi.org/10.1098/rsif.2024.0270","url":null,"abstract":"<p><p>Predictions of airborne infection risk can be made based on the fraction of rebreathed air inferred from point measurements of carbon dioxide (CO_{[Formula: see text]}). We investigate the extent to which environmental factors, particularly spatial variations due to the ventilation provision, affect the uncertainty in these predictions. Spatial variations are expected to be especially problematic in naturally ventilated spaces, which include the majority of classrooms in the UK. An idealized classroom, broadly representative of the physics of (buoyancy-driven) displacement ventilation, is examined using computational fluid dynamics, with different ventilation configurations. Passive tracers are used to model both the CO_{[Formula: see text]} generated by all 32 occupants and the breath of a single infectious individual (located in nine different regions). The distribution of infected breath is shown to depend strongly on the distance from the release location but is also affected by the pattern of the ventilating flow, including the presence of stagnating regions. However, far-field exposure predictions based on single point measurements of CO_{[Formula: see text]} within the breathing zone are shown to rarely differ from the actual exposure to infected breath by more than a factor of two-we argue this uncertainty is small compared with other uncertainties inherent in modelling airborne infection risk.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240270"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: The effect of step size on straight-line orientation.","authors":"Lana Khaldy, Orit Peleg, Claudia Tocco, L Mahadevan, Marcus Byrne, Marie Dacke","doi":"10.1098/rsif.2024.0580","DOIUrl":"10.1098/rsif.2024.0580","url":null,"abstract":"","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240580"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11522986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of synchronized growth oscillations in filamentous fungi.","authors":"Praneet Prakash, Xue Jiang, Luke Richards, Zoe Schofield, Patrick Schäfer, Marco Polin, Orkun S Soyer, Munehiro Asally","doi":"10.1098/rsif.2024.0574","DOIUrl":"10.1098/rsif.2024.0574","url":null,"abstract":"<p><p>Many species of soil fungi grow in the form of branched networks that enable long-range communication and mass flow of nutrient. These networks play important roles in the soil ecosystem as a major decomposer of organic materials. While there have been investigations on the branching of the fungal networks, their long-term growth dynamics in space and time is still not very well understood. In this study, we monitor the spatio-temporal growth dynamics of the plant-promoting filamentous fungus <i>Serendipita indica</i> for several days in a controlled environment within a microfluidic chamber. We find that <i>S. indica</i> cells display synchronized growth oscillations with the onset of sporulation and at a period of 3 h. Quantifying this experimental synchronization of oscillatory dynamics, we show that the synchronization can be recapitulated by the nearest neighbour Kuramoto model with a millimetre-scale cell-cell coupling. The microfluidic set-up presented in this work may aid the future characterization of the molecular mechanisms of the cell-cell communication, which could lead to biophysical approaches for controlling fungi growth and reproductive sporulation in soil and plant health management.</p>","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240574"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}