Journal of The Royal Society Interface最新文献_第4页

Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection. 用雷米地韦对 SARS-CoV-2 感染进行抗病毒治疗的宿主内动态变化。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-11-01 Epub Date: 2024-11-27 DOI: 10.1098/rsif.2024.0536

Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis

{"title":"Within-host dynamics of antiviral treatment with remdesivir for SARS-CoV-2 infection.","authors":"Lea Schuh, Peter V Markov, Ioanna Voulgaridi, Zacharoula Bogogiannidou, Varvara A Mouchtouri, Christos Hadjichristodoulou, Nikolaos I Stilianakis","doi":"10.1098/rsif.2024.0536","DOIUrl":"10.1098/rsif.2024.0536","url":null,"abstract":"The effectiveness of antiviral treatment with remdesivir against COVID-19 has been investigated in clinical trials suggesting earlier recovery. However, this effect seems to be rather modest. In this study, we tracked the clinical course of SARS-CoV-2 infections in 369 COVID-19 individuals across a spectrum of illness severities, including both untreated individuals and individuals who received antiviral treatment with remdesivir. Moreover, using a process-based mathematical model, we quantified and analysed the within-host infection dynamics of a total of 88 individuals, of which 69 were untreated and 19 antiviral-treated individuals. For untreated individuals, we found that those hospitalized exhibit lower levels of early immune response and higher cumulative viral loads than those who were not. For treated individuals, we found that those who died were on average hospitalized later after symptom onset than those who survived, underscoring the importance of early medical intervention for severe COVID-19. Finally, our model estimates a rather limited antiviral activity of remdesivir. Our results provide valuable insights into the clinical course of COVID-19 during antiviral treatment with remdesivir and suggest the need for alternative treatment regimens.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 220","pages":"20240536"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11597410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue. 输液方向对各向异性组织对流增强给药的影响

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-02 DOI: 10.1098/rsif.2024.0378

Yi Yang, Tian Yuan, Ferdinando Rodriguez Y Baena, Daniele Dini, Wenbo Zhan

{"title":"Effect of infusion direction on convection-enhanced drug delivery to anisotropic tissue.","authors":"Yi Yang, Tian Yuan, Ferdinando Rodriguez Y Baena, Daniele Dini, Wenbo Zhan","doi":"10.1098/rsif.2024.0378","DOIUrl":"10.1098/rsif.2024.0378","url":null,"abstract":"Convection-enhanced delivery (CED) can effectively overcome the blood-brain barrier by infusing drugs directly into diseased sites in the brain using a catheter, but its clinical performance still needs to be improved. This is strongly related to the highly anisotropic characteristics of brain white matter, which results in difficulties in controlling drug transport and distribution in space. In this study, the potential to improve the delivery of six drugs by adjusting the placement of the infusion catheter is examined using a mathematical model and accurate numerical simulations that account simultaneously for the interstitial fluid (ISF) flow and drug transport processes in CED. The results demonstrate the ability of this direct infusion to enhance ISF flow and therefore facilitate drug transport. However, this enhancement is highly anisotropic, subject to the orientation of local axon bundles and is limited within a small region close to the infusion site. Drugs respond in different ways to infusion direction: the results of our simulations show that while some drugs are almost insensitive to infusion direction, this strongly affects other compounds in terms of isotropy of drug distribution from the catheter. These findings can serve as a reference for planning treatments using CED.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240378"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: 'Impact of infectious diseases on wild Bovidae populations in Thailand: insights from population modelling and disease dynamics' (2024), by Horpiencharoen et al. 更正："传染病对泰国野生牛科种群的影响：种群建模和疾病动态的启示"（2024 年），作者 Horpiencharoen 等人。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.1098/rsif.2024.0610

Wantida Horpiencharoen, Jonathan C Marshall, Renata L Muylaert, Reju Sam John, David Hayman

引用次数: 0

A model of task-level human stepping regulation yields semistable walking. 任务级人类步态调节模型可实现半稳定行走。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1098/rsif.2024.0151

Navendu S Patil, Jonathan B Dingwell, Joseph P Cusumano

{"title":"A model of task-level human stepping regulation yields semistable walking.","authors":"Navendu S Patil, Jonathan B Dingwell, Joseph P Cusumano","doi":"10.1098/rsif.2024.0151","DOIUrl":"10.1098/rsif.2024.0151","url":null,"abstract":"A simple lateral dynamic walker, with swing leg dynamics and three adjustable input parameters, is used to study how motor regulation affects frontal-plane stepping. Motivated by experimental observations and phenomenological models, we imposed task-level multi-objective regulation targeting the walker's optimal lateral foot placement at each step. The regulator prioritizes achieving step width and lateral body position goals to varying degrees by choosing a mixture parameter. Our model thus integrates a lateral mechanical template, which captures the fundamental mechanics of frontal-plane walking, with a lateral motor regulation template, an empirically verified model of how humans manipulate lateral foot placements in a goal-directed manner. The model captures experimentally observed stepping fluctuation statistics and demonstrates how linear empirical models of stepping dynamics can emerge from first-principles nonlinear mechanics. We find that task-level regulation gives rise to a goal-equivalent manifold in the system's extended state space of mechanical states and inputs, a subset of which contains a continuum of period-1 gaits forming a semistable set: perturbations off of any of its gaits result in transients that return to the set, though typically to different gaits.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240151"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461082/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism. 用瞬态反常扩散形式分析寄生线虫成虫在性别混合群体中的聚集。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1098/rsif.2024.0327

Ruth Leben, Sebastian Rausch, Laura Elomaa, Anja E Hauser, Marie Weinhart, Sabine C Fischer, Holger Stark, Susanne Hartmann, Raluca Niesner

{"title":"Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism.","authors":"Ruth Leben, Sebastian Rausch, Laura Elomaa, Anja E Hauser, Marie Weinhart, Sabine C Fischer, Holger Stark, Susanne Hartmann, Raluca Niesner","doi":"10.1098/rsif.2024.0327","DOIUrl":"10.1098/rsif.2024.0327","url":null,"abstract":"Intestinal parasitic worms are widespread throughout the world, causing chronic infections in humans and animals. However, very little is known about the locomotion of the worms in the host gut. We studied the movement of Heligmosomoides bakeri, naturally infecting mice, and used as an animal model for roundworm infections. We investigated the locomotion of H. bakeri in simplified environments mimicking key physical features of the intestinal lumen, i.e. medium viscosity and intestinal villi topology. We found that the motion sequence of these nematodes is non-periodic, but the migration could be described by transient anomalous diffusion. Aggregation as a result of biased, enhanced-diffusive locomotion of nematodes in sex-mixed groups was detected. This locomotion is probably stimulated by mating and reproduction, while single nematodes move randomly (diffusive). Natural physical obstacles such as high mucus-like viscosity or villi topology slowed down but did not entirely prevent nematode aggregation. Additionally, the mean displacement rate of nematodes in sex-mixed groups of 3.0 × 10-3 mm s-1 in a mucus-like medium is in good agreement with estimates of migration velocities of 10-4 to 10-3 mm s-1 in the gut. Our data indicate H. bakeri motion to be non-periodic and their migration random (diffusive-like), but triggerable by the presence of kin.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240327"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11461085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brain-wide solute transport model of the glymphatic system. 甘液系统的全脑溶质运输模型。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-23 DOI: 10.1098/rsif.2024.0369

Keelin Quirk, Kimberly A S Boster, Jeffrey Tithof, Douglas H Kelley

{"title":"A brain-wide solute transport model of the glymphatic system.","authors":"Keelin Quirk, Kimberly A S Boster, Jeffrey Tithof, Douglas H Kelley","doi":"10.1098/rsif.2024.0369","DOIUrl":"https://doi.org/10.1098/rsif.2024.0369","url":null,"abstract":"Brain waste is largely cleared via diffusion and advection in cerebrospinal fluid (CSF). CSF flows through a pathway referred to as the glymphatic system, which is also being targeted for delivering drugs to the brain. Despite the importance of solute transport, no brain-wide models for predicting clearance and delivery through perivascular pathways and adjacent parenchyma existed. We devised such a model by upgrading an existing model of CSF flow in the mouse brain to additionally solve advection-diffusion equations, thereby estimating solute transport. We simulated steady-state transport of 3 kDa dextran injected proximal to the perivascular space (PVS) of the middle cerebral artery, mimicking in vivo experiments. We performed a sensitivity analysis of 11 biological properties of PVSs and brain parenchyma by repeatedly simulating solute transport with varying parameter values. Parameter combinations that led to a large total pressure gradient, poor CSF perfusion or a steep solute gradient were deemed unrealistic. Solute concentrations in parenchyma were most sensitive to changes in pial PVS size, as this parameter linearly affects volume flow rates. We also found that realistic transport requires both highly permeable penetrating PVSs and high-resistance parenchyma. This study highlights the potential of brain-wide models to provide insights into solute transport processes.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240369"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11496954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inertial coupling of the hummingbird body in the flight mechanics of an escape manoeuvre. 蜂鸟身体在逃逸机动飞行力学中的惯性耦合。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.1098/rsif.2024.0391

Mohammad Nasirul Haque, Bret W Tobalske, Bo Cheng, Haoxiang Luo

引用次数: 0

Frequency-dependent returns in nonlinear public goods games. 非线性公共产品博弈中依赖频率的回报。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-30 DOI: 10.1098/rsif.2024.0334

Christoph Hauert, Alex McAvoy

{"title":"Frequency-dependent returns in nonlinear public goods games.","authors":"Christoph Hauert, Alex McAvoy","doi":"10.1098/rsif.2024.0334","DOIUrl":"10.1098/rsif.2024.0334","url":null,"abstract":"When individuals interact in groups, the evolution of cooperation is traditionally modelled using the framework of public goods games. These models often assume that the return of the public goods depends linearly on the fraction of contributors. In contrast, in real-life public goods interactions, the return can depend on the size of the investor pool as well. Here, we consider a model in which the multiplication factor (marginal per capita return) for the public goods depends linearly on how many contribute, which results in a nonlinear model of public goods. This simple model breaks the curse of dominant defection found in linear public goods interactions and gives rise to richer dynamical outcomes in evolutionary settings. We provide an in-depth analysis of the more varied decisions by the classical rational player in nonlinear public goods interactions as well as a mechanistic, microscopic derivation of the evolutionary outcomes for the stochastic dynamics in finite populations and in the deterministic limit of infinite populations. This kind of nonlinearity provides a natural way to model public goods with diminishing returns as well as economies of scale.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240334"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11521596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding burst swimming performance: a scaling perspective on time-to-fatigue. 解码爆发性游泳成绩：从时间到疲劳的比例视角。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-02 DOI: 10.1098/rsif.2024.0276

Muhammad Usama Ashraf, Daniel Nyqvist, Claudio Comoglio, Vladimir Nikora, Andrea Marion, Paolo Domenici, Costantino Manes

{"title":"Decoding burst swimming performance: a scaling perspective on time-to-fatigue.","authors":"Muhammad Usama Ashraf, Daniel Nyqvist, Claudio Comoglio, Vladimir Nikora, Andrea Marion, Paolo Domenici, Costantino Manes","doi":"10.1098/rsif.2024.0276","DOIUrl":"10.1098/rsif.2024.0276","url":null,"abstract":"Fatigue curves quantify fish swimming performance, providing information about the time ([Formula: see text]) fish can swim against a steady flow velocity (Uf) before fatiguing. Such curves represent a key tool for many applications in ecological engineering, especially for fish pass design and management. Despite years of research, though, our current ability to model fatigue curves still lacks theoretical foundations and relies primarily on fitting empirical data, as obtained from time-consuming and costly experiments. In the present article, we address this shortcoming by proposing a theoretical analysis that builds upon concepts of fish hydrodynamics to derive scaling laws linking statistical properties of [Formula: see text] to velocities Uf, pertaining to the so-called burst range. Theoretical arguments, in the present study, suggest that the proposed scaling laws may hold true for all fish species and sizes. A new experimental database obtained from over 800 trials and five small-sized Cypriniformes support theoretical predictions satisfactorily and calls for further experiments on more fish species and sizes to confirm their general validity.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"21 219","pages":"20240276"},"PeriodicalIF":3.7,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial correlations in laboratory insect swarms. 实验室昆虫群的空间相关性

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2024-10-01 Epub Date: 2024-10-09 DOI: 10.1098/rsif.2024.0450

Andy M Reynolds

引用次数: 0