Journal of The Royal Society Interface最新文献_第2页

Scientific hypothesis generation by large language models: laboratory validation in breast cancer treatment. 大语言模型的科学假设生成：乳腺癌治疗的实验室验证。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.1098/rsif.2024.0674

Abbi Abdel-Rehim, Hector Zenil, Oghenejokpeme Orhobor, Marie Fisher, Ross J Collins, Elizabeth Bourne, Gareth W Fearnley, Emma Tate, Holly X Smith, Larisa N Soldatova, Ross King

{"title":"Scientific hypothesis generation by large language models: laboratory validation in breast cancer treatment.","authors":"Abbi Abdel-Rehim, Hector Zenil, Oghenejokpeme Orhobor, Marie Fisher, Ross J Collins, Elizabeth Bourne, Gareth W Fearnley, Emma Tate, Holly X Smith, Larisa N Soldatova, Ross King","doi":"10.1098/rsif.2024.0674","DOIUrl":"10.1098/rsif.2024.0674","url":null,"abstract":"Large language models (LLMs) have transformed artificial intelligence (AI) and achieved breakthrough performance on a wide range of tasks. In science, the most interesting application of LLMs is for hypothesis formation. A feature of LLMs, which results from their probabilistic structure, is that the output text is not necessarily a valid inference from the training text. These are termed 'hallucinations', and are harmful in many applications. In science, some hallucinations may be useful: novel hypotheses whose validity may be tested by laboratory experiments. Here, we experimentally test the application of LLMs as a source of scientific hypotheses using the domain of breast cancer treatment. We applied the LLM GPT4 to hypothesize novel synergistic pairs of US Food and Drug Administration (FDA)-approved non-cancer drugs that target the MCF7 breast cancer cell line relative to the non-tumorigenic breast cell line MCF10A. In the first round of laboratory experiments, GPT4 succeeded in discovering three drug combinations (out of 12 tested) with synergy scores above the positive controls. GPT4 then generated new combinations based on its initial results, this generated three more combinations with positive synergy scores (out of four tested). We conclude that LLMs are a valuable source of scientific hypotheses.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240674"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12134935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical mechanical patterns in morphogenesis: from mollusc shells to plants, fungi and animals. 形态发生中的等级机械模式：从软体动物壳到植物、真菌和动物。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2024.0918

Derek E Moulton, Alain Goriely, Régis Chirat

{"title":"Hierarchical mechanical patterns in morphogenesis: from mollusc shells to plants, fungi and animals.","authors":"Derek E Moulton, Alain Goriely, Régis Chirat","doi":"10.1098/rsif.2024.0918","DOIUrl":"10.1098/rsif.2024.0918","url":null,"abstract":"Hierarchical patterns, made up of subunits of different sizes intercalated with each other, are present in diverse organisms spanning the plant, fungi and animal kingdoms. Despite these structures appearing in different kingdoms, at different scales, at different levels of biological organization and involving different developmental mechanisms, their sequential development follows a generic principle of recursive subdivision of space, associated with domain growth and an irreversibility condition. To investigate the morphogenesis of such hierarchical patterns, we develop a theoretical framework, based on morphoelasticity, the biomechanics of growth. In our model, the hierarchical pattern is modelled as a sum of Gaussians, each representing a subunit. The size and spacing of these Gaussians are then determined by minimizing the mechanical energy of the growing system. Our framework is simple enough to be analytically tractable, enabling us to identify the mechanisms necessary for hierarchical pattern formation and providing new insight into the developmental process involved. Our work is specifically motivated by and applied to the context of mollusc shells, in which the hierarchical ridge pattern is in some species dilated to form beautifully exuberant shell edges, which may take the form of a row of needle-like or fractal-like spines, nevertheless maintaining the hierarchical form.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240918"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12188252/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scaly-tail organ enhances static stability during Pel's scaly-tailed flying squirrels' arboreal locomotion. 鳞尾器官增强了佩尔的鳞尾飞鼠在树上运动时的静态稳定性。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2024.0937

Andrew K Schulz, Mrudul Chellapurath, Pranav C Khandelwal, SeyedReza Rezaei, Stefan Merker, Ardian Jusufi

{"title":"Scaly-tail organ enhances static stability during Pel's scaly-tailed flying squirrels' arboreal locomotion.","authors":"Andrew K Schulz, Mrudul Chellapurath, Pranav C Khandelwal, SeyedReza Rezaei, Stefan Merker, Ardian Jusufi","doi":"10.1098/rsif.2024.0937","DOIUrl":"10.1098/rsif.2024.0937","url":null,"abstract":"Scaly-tailed squirrels (Anomaluridae) are one of the least studied mammalian families. Their name is due to a peculiar and unique scaly-tail organ extruding from the caudal vertebra that has been predicted to help reduce skidding. This study investigates the function of the scaly-tail organ found in Anomalurus pelii, investigating its potential role in enhancing arboreal locomotion. As these animals glide from tree to tree in a habitat abundant with smooth-bark trees, we hypothesize that the scaly-tail organ assists with friction enhancement in their native smooth-bark habitat. Through a combination of analyses using mathematical and physical models for experimental validation, we explore whether the scaly-tail organ could improve the sliding and pitching stability during perching. Our experimental results showed that the scaly-tail organ can act as a skid-reduction mechanism by enhancing substrate engagement on intermediate roughness substrates by 58%. Mathematical models showed the scaly-tail organ enhances static pitch stability by acting as an additional support point. Our model showed that the scaly-tailed squirrel can reach up to 82.5° inclination without claw force; however, without scales, it reduces to 79.6°. Overall, this research highlights the functional significance of scaly-tail organs in adaptations in scaly-tailed flying squirrels and contributes to our understanding of their locomotion strategies and environmental stresses. Our study also provides insights into innovative locomotion mechanisms for robots operating in arboreal environments.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240937"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The diversity of biological models for bio-inspired aerosol filters. 生物雾化过滤器生物模型的多样性。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2025.0221

Leandra Hamann, Timothy Foat, Alexander Blanke

{"title":"The diversity of biological models for bio-inspired aerosol filters.","authors":"Leandra Hamann, Timothy Foat, Alexander Blanke","doi":"10.1098/rsif.2025.0221","DOIUrl":"10.1098/rsif.2025.0221","url":null,"abstract":"Innovative filtration systems are essential to enhance air quality or improve aerosol sampling for analysis, while addressing challenges such as high energy consumption, clogging and inefficiencies in capturing a wide range of particle diameters. Bio-inspiration provides novel design strategies by translating natural particle separation mechanisms (PSMs) into more efficient, adaptive and sustainable filtration technologies. This review systematically identifies six organismic groups as biological models that use distinct particle capture mechanisms to retain airborne particles for nutrition, reproduction and protection. Filtration-based PSMs in air, such as insect spiracles, hornet silk caps and spider webs, employ dead-end filtration with varying mesh structures to either purify air or capture prey. Non-filtration PSMs, including nasal cavities and wind pollination, rely on passive aerodynamic mechanisms such as impaction, interception and settling for particle retention. Flow regime control is crucial for non-filtration PSMs, where structures like nasal turbinates and pine cone surfaces optimize local airflows. Adhesive mechanisms, found in spider webs and nasal mucus, improve particle attachment. By mapping these principles to aerosol filtration challenges-such as particle adhesion, flow optimization and efficient removal of submicrometre particles-this review identifies promising pathways for bio-inspired aerosol filters in environmental monitoring, industrial hygiene and public health.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250221"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adjoint sensitivity method for parameter estimation: applications to inverted pendulum and human standing balance. 参数估计的伴随灵敏度法：在倒立摆和人站立平衡中的应用。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1098/rsif.2024.0843

Jingtian Chen, Shaoyi Lu, Li Zhang, Tamas Insperger, Gabor Stepan

{"title":"Adjoint sensitivity method for parameter estimation: applications to inverted pendulum and human standing balance.","authors":"Jingtian Chen, Shaoyi Lu, Li Zhang, Tamas Insperger, Gabor Stepan","doi":"10.1098/rsif.2024.0843","DOIUrl":"10.1098/rsif.2024.0843","url":null,"abstract":"The inverted pendulum, a classical mechanical system, often serves as a platform for studying stability and control algorithms. Modelling human standing balance as an inverted pendulum controlled by the time-delayed proportional-derivative (PD) feedback controller can be used effectively to study the related biomechanical mechanisms. In this study, to investigate the human balance control strategy, an adjoint sensitivity analysis method and a corresponding optimizer are implemented to directly determine system parameters, control gains and the time delay in the human balancing model. This study validates the accuracy of the optimizer through numerical simulations and experimental verification based on the physical model of the inverted pendulum on a cart. The experimental results confirm the performance of the identification algorithm for systems involving non-smooth dynamics and inherent time delays. Moreover, the identification based on human balance data indicates that the time-delayed PD feedback controller effectively represents the human balance control strategy. Additionally, the identification reveals a tendency in the control strategy: the control gains are located in the lower-left region of the stability diagram, indicating that the human body tends to adopt an optimal control strategy that minimizes energy consumption.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240843"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of diagenesis in archaeological human second metacarpal bones using the intensity of the small angle X-ray scattering D-period peak. 用小角x射线散射d周期峰强度评价考古人类第二掌骨成岩作用。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2024.0826

Laura Lynne Gardner, William Abramovich, Misha Romanov, Stefan Flohr, Uwe Kierdorf, Horst Kierdorf, Jonathan D Almer, Steven D Jacobsen, Gabriela B Gonzalez, J-S Park, Stuart R Stock

{"title":"Assessment of diagenesis in archaeological human second metacarpal bones using the intensity of the small angle X-ray scattering D-period peak.","authors":"Laura Lynne Gardner, William Abramovich, Misha Romanov, Stefan Flohr, Uwe Kierdorf, Horst Kierdorf, Jonathan D Almer, Steven D Jacobsen, Gabriela B Gonzalez, J-S Park, Stuart R Stock","doi":"10.1098/rsif.2024.0826","DOIUrl":"10.1098/rsif.2024.0826","url":null,"abstract":"Bone consists mainly of carbonated apatite (cAp) nanoplatelets embedded in a matrix of collagen fibrils. Earlier, high-energy small angle X-ray scattering (SAXS) studies of archaeological adult human second metacarpal bones (mc2) found collagen D-period peaks with high-intensity ID in specimens in which microcomputed tomography (microCT) showed little diagenesis and ID ~ 0 for specimens where microCT revealed severe diagenesis (Park et al. 2022 Int. J. Osteoarchaeol. 32, 170-181 (doi:10.1002/oa.3053); Stock et al. 2022 Int. J. Osteoarchaeol. 32, 120-131 (doi:10.1002/oa.3049)). The present paper uses SAXS at beamline 1-ID, Advanced Photon Source, Argonne National Laboratory and other techniques to study a set of 10 mc2 from an early Medieval cemetery at Greding, Germany. We hypothesized that non-invasive measurement of ID would provide an accurate and rapid (approx. 6 min/specimen) assessment of diagenesis in archaeological mc2. Results of Raman spectroscopy, laboratory microCT and backscattered electron, reflected light and polarized transmitted light microscopies confirmed the SAXS determinations, but lattice parameter values from X-ray diffraction were uncorrelated with ID value. Age-at-death estimates placed the 10 mc2 in three age categories (young adult, middle adult, old adult): lattice parameters from X-ray diffraction were uncorrelated with age at death. Cross-sectional bone area fraction from microCT dropped noticeably for the older age cohort.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240826"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emergent dynamical phases and collective motion in termites. 白蚁的涌现动力阶段和集体运动。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-25 DOI: 10.1098/rsif.2025.0097

Leticia Ribeiro Paiva, Sidiney Geraldo Alves, Og DeSouza, Octavio Miramontes

{"title":"Emergent dynamical phases and collective motion in termites.","authors":"Leticia Ribeiro Paiva, Sidiney Geraldo Alves, Og DeSouza, Octavio Miramontes","doi":"10.1098/rsif.2025.0097","DOIUrl":"10.1098/rsif.2025.0097","url":null,"abstract":"Termites which are able to forage in the open can be often seen, in the field or in the laboratory: (i) wandering around, forming no observable pattern, (ii) clustering themselves in a dense and almost immobile pack, or (iii) milling about in a circular movement. Despite being well reported patterns, they are normally regarded as independent phenomena whose specific traits have never been properly quantified. Evidence, however, favours the hypothesis that these are interdependent patterns, arising from self-organized interactions and movement among workers. After all, termites are a form of active matter where blind cooperative individuals are self-propelled and lack the possibility of visual cues to spatially orientate and align. It follows that their non-trivial close-contact patterns could generate motion-collision-induced phase separations. This would then trigger the emergence of these three patterns (disorder, clustering, milling) as parts of the same continuum. By inspecting termite groups confined in arenas, we could quantitatively describe each one of these patterns in detail. We identified disorder, clustering and milling spatial patterns. These phases and their transitions are characterized aiming to offer refinements in the understanding of these aspects of self-propelled particles in active matter where close-range contacts and collisions are important.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20250097"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic causal modelling in probabilistic programming languages. 概率编程语言中的动态因果建模。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-04 DOI: 10.1098/rsif.2024.0880

Nina Baldy, Marmaduke Woodman, Viktor K Jirsa, Meysam Hashemi

{"title":"Dynamic causal modelling in probabilistic programming languages.","authors":"Nina Baldy, Marmaduke Woodman, Viktor K Jirsa, Meysam Hashemi","doi":"10.1098/rsif.2024.0880","DOIUrl":"10.1098/rsif.2024.0880","url":null,"abstract":"Understanding the intricate dynamics of brain activities necessitates models that incorporate causality and nonlinearity. Dynamic causal modelling (DCM) presents a statistical framework that embraces causal relationships among brain regions and their responses to experimental manipulations, such as stimulation. In this study, we perform Bayesian inference on a neurobiologically plausible generative model that simulates event-related potentials observed in magneto/encephalography data. This translates into probabilistic inference of latent and observed states of a system driven by input stimuli, described by a set of nonlinear ordinary differential equations (ODEs) and potentially correlated parameters. We provide a guideline for reliable inference in the presence of multimodality, which arises from parameter degeneracy, ultimately enhancing the predictive accuracy of neural dynamics. Solutions include optimizing the hyperparameters, leveraging initialization with prior information and employing weighted stacking based on predictive accuracy. Moreover, we implement the inference and conduct comprehensive model comparison in several probabilistic programming languages to streamline the process and benchmark their efficiency. Our investigation shows that model inversion in DCM extends beyond variational approximation frameworks, demonstrating the effectiveness of gradient-based Markov chain Monte Carlo methods. We illustrate the accuracy and efficiency of posterior estimation using a self-tuning variant of Hamiltonian Monte Carlo and the automatic Laplace approximation, effectively addressing parameter degeneracy challenges. This technical endeavour holds the potential to advance the inversion of state-space ODE models, and contribute to neuroscience research and applications in neuroimaging through automatic DCM.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240880"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12133347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology. 用AFM微流变学分析分离和活MCF7癌细胞细胞核的粘弹性差异。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1098/rsif.2024.0885

Ellen Juel Pørtner, Anna Mularski, Tobias William Jarrett, Stine Lauritzen Sønder, Jesper Nylandsted, Adam Cohen Simonsen

{"title":"Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology.","authors":"Ellen Juel Pørtner, Anna Mularski, Tobias William Jarrett, Stine Lauritzen Sønder, Jesper Nylandsted, Adam Cohen Simonsen","doi":"10.1098/rsif.2024.0885","DOIUrl":"10.1098/rsif.2024.0885","url":null,"abstract":"Cell nuclei are commonly isolated for mechanobiology studies although isolated nuclei may display viscoelastic properties differing from those of live cells. Nuclear mechanics is generally dependent on the time scale of the applied load and cannot accurately be assessed by a simple elasticity parameter. Active microrheology with an atomic force microscope (AFMMR) is a versatile tool for probing nuclear mechanics and we employ the technique for exploring isolated and live-cell nuclei in MCF7 cells, including the significance of actin depolymerization. We successfully validate the method using polyacrylamide hydrogels with correction for cantilever drag in the fluid. The AFMMR results reveal that isolated and live-cell nuclei are equivalent to within a scaling factor, in their frequency-dependent modulus, with isolated nuclei being softer. The loss tangent reveals a transition from solid- to liquid-like behaviour occurring at higher frequency in isolated than in live-cell nuclei. Viscoelastic modelling using the Jeffreys model describes the frequency-dependent modulus of all measured nuclei. Model parameters display sensitivity to nuclei isolation and to actin depolymerization in live cells. Sections of the Jeffreys circuit can potentially be assigned to internal and external nucleus structures, respectively, thereby establishing a minimal mechanistic framework for interpreting microrheology data on cell nuclei.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240885"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimal switching strategies for navigation in stochastic settings. 随机环境下导航的最优切换策略。

IF 3.7 2区综合性期刊

Journal of The Royal Society Interface Pub Date : 2025-06-01 Epub Date: 2025-06-18 DOI: 10.1098/rsif.2024.0677

Francesco Mori, L Mahadevan

{"title":"Optimal switching strategies for navigation in stochastic settings.","authors":"Francesco Mori, L Mahadevan","doi":"10.1098/rsif.2024.0677","DOIUrl":"10.1098/rsif.2024.0677","url":null,"abstract":"When navigating complex environments, animals often combine multiple strategies to mitigate the effects of external disturbances. These modalities often correspond to different sources of information, leading to speed - accuracy trade-offs. Inspired by the intermittent reorientation strategy seen in the behaviour of the dung beetle, we consider the problem of the navigation strategy of a correlated random walker moving in two dimensions. We assume that the heading of the walker can be reoriented to the preferred direction by paying a fixed cost as it tries to maximize its total displacement in a fixed direction. Using optimal control theory, we derive analytically and confirm numerically the strategy that maximizes the walker's speed, and show that the average time between reorientations scales inversely with the magnitude of the environmental noise. We then extend our framework to describe execution errors and sensory acquisition noise. As a result, we provide a range of testable predictions and suggest new experimental directions. Our approach may be amenable to other navigation problems involving multiple sensory modalities that require switching between egocentric and geocentric strategies.","PeriodicalId":17488,"journal":{"name":"Journal of The Royal Society Interface","volume":"22 227","pages":"20240677"},"PeriodicalIF":3.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12173510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0