Journal of King Saud University - Science最新文献

{"title":"Synthesis and exploration of breast cancer agent from curcumin analogs based on 3-benzyloxybenzaldehyde","authors":"Endang Astuti, Frika Rahmawari, Kasta Gurning, Jihan Alfiyah Kultsum, Zarah Aulia, Sugeng Triono, Tutik Dwi Wahyuningsih, Winarto Haryadi, Harno Dwi Pranowo","doi":"10.25259/jksus_436_2024","DOIUrl":"https://doi.org/10.25259/jksus_436_2024","url":null,"abstract":"This study aims to explore potential anticancer drug candidates by conducting synthesis, cytotoxic activity, and immunocytochemistry against T47D, HER2, MCF-7, and 4T1 breast cancer cell lines, along with bioinformatics analysis, molecular docking, and ADMET (absorption, distribution, metabolism, excretion, toxicity) studies. Synthesis of curcumin analogs was carried out by reacting 3-benzyloxybenzaldehyde and piperidone derivatives through aldol condensation, while structure elucidation was analyzed with Fourier transform infrared (FTIR) and nuclear magnetic resonance ( 1 H-NMR and 13 C-NMR) instruments. In vitro analysis revealed that curcumin analogs C1 and C2 had cytotoxic activity (IC 50 ), of which C1 was the highest at 5.45 μg/mL against 4T1 and C2 at 1.75 μg/mL against HER2. The selectivity index indicates that C1 reveals high selectivity on 4T1 cell lines, while C2 is not selective against all breast cancer cell lines. A critical step in tumor initiation and progression is the evasion of apoptosis, a process tightly regulated by proteins such as p53 and BCL-2, which play pivotal roles in controlling cellular survival and programmed cell death. Immunocytochemistry shows the expression of p53 and BCL-2 proteins from C1. Treatment with C1 at 2.725 μg/mL increased p53 protein expression by 86.36% in the 4T1 cell line. In T47D cells, BCL-2 expression decreased slightly at C1 concentrations of 28.34 and 14.17 μg/mL. The pharmacokinetic profile showed increased absorption, tissue distribution, and lower toxicity than curcumin. The main target protein signaling pathways in breast cancer for compounds C1 and C2 can be identified by integrating biological networks, pharmacological data, and molecular interactions, providing insights into potential therapeutic strategies. The outcomes of this study identified that AKT1 is the primary target protein for the curcumin analog compounds C1 and C2. Inhibition of AKT1 activation by compounds C1 and C2 may represent a promising therapeutic strategy for the treatment of breast cancer. However, due to its lack of selectivity, C2 is best considered a lead compound for optimization, whereas C1 demonstrates both cytotoxicity and selectivity, making it the stronger therapeutic candidate. For further development, it is recommended to conduct direct experimental studies in the laboratory to confirm the role of AKT1 as the main molecular target.","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"37 1","pages":"4362024-4362024"},"PeriodicalIF":0.0,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-ablative laser skin rejuvenation by targeting indigenous chromophores","authors":"Muna B. Mustafa ,&nbsp;Walid K. Hamoudi ,&nbsp;Khawla S. Khashan","doi":"10.1016/j.jksus.2024.103516","DOIUrl":"10.1016/j.jksus.2024.103516","url":null,"abstract":"<div><div>Three pulsed laser systems: 980 nm semiconductor diode laser, 1064 nm Nd: YAG laser and long pulse- fractional 2940 nm pulsed Er: YAG were used to treat some non-ablative skin rejuvenation applications. These three wavelengths can target the three main indigenous chromophores (melanin, hemoglobin and water) of the skin to treat different skin disorders. The efficacy of these lasers was assessed in the treatment of age spots, enlarged veins and wrinkles. The chromophore type and location of a specific disorder was taken into consideration when working out, in advance, the required laser fluence. The absorption of laser photons and the reabsorbed photon scattering were calculated and used to work out the temperature rise in the targeted tissue. The results indicated very good outcome of age spots with 980 nm laser, excellent clearance of the varicose veins with the use of 1064 nm laser and very good smoothing of fine lines wrinkles on forehead. Advances may involve conducting wavelengths or developing customizable protocols for different skin types. Long-term studies on patient outcomes to help establish standardized protocols and improve efficacy in clinical uses.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103516"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142593175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory potential of aloe vera meatballs and their impact on rheumatoid arthritis","authors":"Warda Khan ,&nbsp;Rizwan Shaukat ,&nbsp;Awais Khan ,&nbsp;Amna Khan ,&nbsp;Bushra Ahmad ,&nbsp;Saira Saleem ,&nbsp;Mohammad Abul Farah ,&nbsp;Waqas Amin ,&nbsp;Obaid Ullah Khan","doi":"10.1016/j.jksus.2024.103573","DOIUrl":"10.1016/j.jksus.2024.103573","url":null,"abstract":"<div><div>Rheumatoid Arthritis is an auto-immune condition resulting in the formation of autoantibodies that cause joint and systemic inflammation. Different signs and symptoms include pain, redness, and swelling in joints leading to difficulties performing day-to-day activities and restlessness. The prevalence of Rheumatoid Arthritis worldwide and in Pakistan is 0.5 % and 1 %, respectively, with females experiencing a higher ratio due to improper diet, weight loss, fatigue, and housework. Aloe vera chicken meatballs, rich in protein, calories, phenolic compounds, polysaccharides, and collagen protein, have anti-inflammatory effects on arthritis patients by reducing inflammatory mediator production. By considering this, we conducted an experiment on the production of Aloe Vera based chicken meatballs with different doses including (100 g of chicken, 10 g of Aloe Vera + 90 g of Chicken, 20 g of Aloe Vera + 80 g of Chicken, 30 g of Aloe Vera + 70 g of Chicken) at Meat Science Nutraceutical Laboratory, National Institute of Food Science and Technology, University of Agriculture, Faisalabad. 100 g of chicken was considered as a control treatment. The meatballs were tested on four different groups of rheumatoid patients at Allied Hospital Faisalabad. The results indicated that the combination (20 g of Aloe Vera + 80 g of Chicken) yielded the most significant reduction in the Arthritis Factor Test by 26 %, compared to untreated arthritis patients. Additionally, it showed 20 % higher acceptability than the control group. Therefore, meatballs containing 20 g of Aloe Vera and 80 g of Chicken were deemed the most effective biomedicine for alleviating rheumatoid arthritis in humans.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103573"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant activities of seeds and sprouts of Momordica charantia and their antibacterial efficacies against pathogenic bacteria isolated from hospitalized patients","authors":"Md. Shihab Uddin Sohag,&nbsp;Md. Al-Monsur,&nbsp;Md. Mushfiqur Rahman,&nbsp;Md. Al Amin Sarker,&nbsp;Sanjay Dutta,&nbsp;Fazle Rabbi Shakil Ahmed","doi":"10.1016/j.jksus.2024.103580","DOIUrl":"10.1016/j.jksus.2024.103580","url":null,"abstract":"<div><div>During sprouting, significant chemical transformations frequently transpire, leading to variations in the concentrations of diverse bioactive compounds present in the seeds. Consequently, seeds and sprouts may have altered bioactivity. The current study aimed to evaluate the <em>in vitro</em> antioxidant activities of crude hydroalcoholic (70 % ethanol and 30 % distilled water) extracts of <em>Momordica charantia</em> seeds and sprouts and their antibacterial efficacies against morbific bacteria sourced from hospitalized patients. Utilizing three assays- DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid), and ferric ions reducing power), the antioxidant activities were evaluated. The results revealed that the sprout extract significantly outperformed the seed extract in terms of Fe³⁺ ions reducing power, DPPH radical scavenging activity (IC₅₀ = 163.37 ± 23.91 μg/ml), and ABTS radical scavenging activity (IC₅₀ = 30.56 ± 6.90 µg/ml). The antibacterial efficacies against five morbific bacteria (<em>Enterobacter cloacae, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa,</em> and <em>Klebsiella oxytoca</em>) isolated from hospitalized patients were evaluated by the agar disc diffusion method. The findings indicated that the extracts derived from both sprouts and seeds exerted potent antibacterial efficacy by suppressing the growth of several clinical isolates. Both extracts possessed statistically significant (p &lt; 0.05) antibacterial activity against <em>Enterobacter cloacae</em> and <em>Escherichia coli</em>. Seed extract had greater antibacterial activity than sprout extract against <em>Enterococcus faecalis</em>. <em>Pseudomonas aeruginosa</em> exhibited the lowest and identical susceptibility at three distinct concentrations (200 μg, 400 μg, and 800 μg) of seed extract. No extracts have shown any antibacterial action against <em>Klebsiella oxytoca</em>. The results of the study indicate that <em>Momordica charantia</em> sprouts exhibit a greater capacity to scavenge free radicals as antioxidants, whereas seeds possess more potent and broader antibacterial efficacy compared to sprouts.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103580"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity analysis and application of single-valued neutrosophic transportaion problem","authors":"M. Kanchana,&nbsp;K. Kavitha","doi":"10.1016/j.jksus.2024.103567","DOIUrl":"10.1016/j.jksus.2024.103567","url":null,"abstract":"<div><div>The neutrosophic set serves as a powerful tool for addressing complexity, ambiguity, and managing imperfect and inconsistent information in the digital world. Graph theory plays a crucial role in determining the shortest path for neutrosophic sets through graph algorithms. This article introduces a novel algorithm, the bipartite graph contraction algorithm, to elucidate the graphical aspects within neutrosophic set theory by using score function for ranking. The proposed bipartite neutrosophic graph contraction algorithm is applied to solve a single-valued neutrosophic network, where the transportation unit cost is expressed as a trapezoidal single-valued neutrosophic number and produced the result as <span><math><mrow><mo>〈</mo><mfenced><mrow><mrow><mn>364</mn><mo>,</mo><mn>537</mn><mo>,</mo><mn>694</mn><mo>,</mo><mn>908</mn></mrow></mrow></mfenced><mo>;</mo><mn>0</mn><mo>.</mo><mrow><mn>3</mn><mo>,</mo><mn>0.7</mn><mo>,</mo><mn>0.7</mn></mrow><mo>〉</mo></mrow></math></span>. A comparative analysis with an existing algorithm is conducted, and a novel introduction of sensitivity analysis in the realm of neutrosophic set theory is presented to assess the optimality of the result in neutrosophic transportation problems.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103567"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143153530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An inertial conjugate gradient projection method for large-scale nonlinear equations and its application in the image restoration problems","authors":"Gonglin Yuan ,&nbsp;Chunzhao Liang ,&nbsp;Yong Li","doi":"10.1016/j.jksus.2024.103547","DOIUrl":"10.1016/j.jksus.2024.103547","url":null,"abstract":"<div><div>Based on the acceleration effect of the inertial extrapolation technique on the convergence of iterative sequences, the number of algorithms incorporating this technique has gradually increased in recent years. Currently, there is a relative paucity of studies focusing on the Polak-Ribière-Polyak (PRP) conjugate gradient algorithm that integrate the inertial extrapolation technique. In this article, we introduce an inertial three-term PRP conjugate gradient projection method by incorporating an inertial extrapolation step into the three-term PRP algorithm, where the search direction exhibits sufficient descent and trust region characteristics. The search rule employs a derivative-free technique. Under suitable hypotheses, the proposed algorithm demonstrates global convergence. Numerical results indicate the superiority and competitiveness of this innovative method. Furthermore, its effectiveness in addressing image restoration problems underscores the practicality of this algorithm.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103547"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143152104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic effect of polystyrene nanoplastics in human umbilical vein endothelial cells (HUVECs) and normal rat kidney cells (NRK52E)","authors":"Maqusood Ahamed,&nbsp;Mohd Javed Akhtar","doi":"10.1016/j.jksus.2024.103505","DOIUrl":"10.1016/j.jksus.2024.103505","url":null,"abstract":"<div><div>Plastics play a crucial role in nearly each aspect of societal production and everyday life, therefore making them one of the most widespread pollutants on a global scale. Because synthetic plastics are not entirely biodegradable, they often remain in the environment and fragment into micro- and nanoplastic particles. The detrimental impacts of nanoplastics on the environment and human health have received substantial worldwide interest in recent years. However, the effects of nanoplastics on human health have not yet been fully explored. Our study aimed to investigate the cytotoxic effects of polystyrene nanoplastics on two distinct mammalian cell lines: normal rat kidney cells (NRK52E) and human umbilical vein endothelial cells (HUVECs). Results showed that polystyrene nanoplastics generate cytotoxicity in both NRK52E and HUVECs in a concentration- and time-dependent manner. Additionally, polystyrene nanoplastics induced pro-oxidant levels (e.g., reactive oxygen species and hydrogen peroxide) and reduced antioxidants (glutathione content and glutathione peroxidase enzyme activity) in both types of cells. We also found that polystyrene nanoplastics cause apoptosis in both NRK52E and HUVECs, as shown by the activation of the caspase-3 enzyme and the loss of mitochondrial membrane potential. Interestingly, it was noticed that the vulnerability of HUVECs cells against polystyrene nanoplastics was a little higher than that of NRK52E cells. Also, the cell toxicity caused by polystyrene nanoplastics in NRK52E and HUVECs was effectively alleviated by co-exposure to a reactive oxygen species inhibitor, N-acetyl-cysteine. This suggests that oxidative stress could be one of the possible pathways by which polystyrene nanoplastics cause cell toxicity. The present work warrants future study to explore the toxicity mechanisms of polystyrene nanoplastics in appropriate <em>in vivo</em> models.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103505"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium nanoparticles produced by Acacia arabica leaf extract and their influence on fresh-cut fruit quality features","authors":"Chinnadurai Veeramani,&nbsp;Mohammed A. Alsaif,&nbsp;Muhammad Ibrar Khan,&nbsp;Ahmed S. El Newehy,&nbsp;Ali Alshammari,&nbsp;Khalid S. Al-Numair","doi":"10.1016/j.jksus.2024.103487","DOIUrl":"10.1016/j.jksus.2024.103487","url":null,"abstract":"<div><div>Calcium oxide nanoparticles have possessed unique structural and numerous applications, including the food preservative, antimicrobial, and chemotherapeutic properties. The study’s goal was to identify and create calcium oxide-derived leaf extract nanoparticles from <em>Acacia arabica</em> (AA) and assess their effectiveness on fresh-cut fruit quality attributes. The calcium oxide nanoparticles (AACaN) produced using AA leaf extract by the simple precipitation method and the AACaN obtained were characterised and confirmed using various analytical techniques. Freshly sliced apple fruit as well as unsliced blueberry and blackberry were immersed in AACaN (10 and 20 µg/mL) at two different concentrations for five minutes before being put in packed polypropylene plastic bags and maintained at 5 °C. According to the quality evaluations of pH, DPPH, 2,2-diphenylpicrylhydrazyl (DPPH), hardness, total soluble solid content (TSS), and sensory analysis. AACaN at 20 µg/mL has the ability to preserve freshly cut fruits of apples as well as unsliced blueberries and blackberries, thereby effectively extending fruits 20-day shelf life in comparison to control (untreated) fruits. This study has concluded that the AA is an ideal source to synthesis calcium oxide nanoparticles, and it was proved by materially characterizing. Moreover, the AACaN at 20 µg/mL proved the apples, blueberry, and blackberry fruits shelf life, which also added a large nutritional value while maintaining a storage quality.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103487"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of chemical inhibitors against mammalian target of rapamycin (mTOR) for primary immunosuppression in recipients of kidney transplant: A systematic review and meta-analysis","authors":"Ahmad Alsulimani ,&nbsp;Ayman K. Johargy ,&nbsp;Hani Faidah ,&nbsp;Ahmad O. Babalghith ,&nbsp;Abdullah F. Aldairi ,&nbsp;Farkad Bantun ,&nbsp;Faraz Ahmad ,&nbsp;Darin Mansor Mathkor ,&nbsp;Shafiul Haque","doi":"10.1016/j.jksus.2024.103481","DOIUrl":"10.1016/j.jksus.2024.103481","url":null,"abstract":"<div><div>The current systematic review and <em>meta</em>-analysis was undertaken to assess the efficaciousness of mammalian target of rapamycin (mTOR) inhibitors in transplant subjects with regards to kidney functions and survival, with special reference to co-administration (or absence of) calcineurin inhibitors (CNIs). The analysis was done through searching and retrieving information from online scholarly databases. The collected data represented outcomes after at least twelve months following transplantation of kidney. It was observed that parameters such as glomerular filtration rate (GFR) was improved in subjects administered with mTOR inhibitors, however some studies indicated that acute rejection following biopsy was dominant in subjects administered with mTOR inhibitors. Owing to their complementary mechanisms of action as well as beneficial effects on mitigating nephrotoxicity, concomitantly with favorable outcomes on parameters such as serum creatinine and GFR leading to increased survival, this <em>meta</em>-analysis proposes early utilization of mTOR inhibitors and CNI minimization in subjects with kidney transplantation.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103481"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant expression of miR-143/miR-223/miR4478 and miR145 as prognostic factor for colorectal cancer patients","authors":"Abdullah M Alhadheq ,&nbsp;Rana Alhadheq ,&nbsp;Saad Alkahtani","doi":"10.1016/j.jksus.2024.103494","DOIUrl":"10.1016/j.jksus.2024.103494","url":null,"abstract":"<div><div>Colorectal cancer (CRC) is a type of malignancy that develops in the colon or rectal region. It develops due to abnormal growth and proliferation of cells in the lining of the colon, forming a tumor. This study included tissue samples (56 malignant and 56 matched normal samples). miRNAs were determined and retrieved from miRBase database and moderated by p53 gene. Expression levels of miRNA were varied. Only miR-223 revealed greater expression than normal matched tissue. mMiR-143, miR-4478, and miR-145 exhibited lower expression than matched normal tissue. Only miR-143 and miR-145 showed considerable variations in the expression among groups while miR-4478 did not demonstrate statistically substantial difference. In conclusion, this study highlights that upregulation of P53 and miR-223 and downregulation of miR-145 and miR-143 were associated with cancer advancement and unfavorable prognosis in Saudi CRC patients, indicating P53, miR-223, miR-145 and miR-143 to be novel and valuable signatures for predicting the outcomes for patients with CRC.</div></div>","PeriodicalId":16205,"journal":{"name":"Journal of King Saud University - Science","volume":"36 11","pages":"Article 103494"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142534699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}