Proceedings of the National Academy of Sciences of the United States of America最新文献

{"title":"Correction for Ferraro et al., Outdated reproductive norms, the naturalistic fallacy, and misunderstandings of welfare in recent call for zoo breed-and-feed programs.","authors":"","doi":"10.1073/pnas.2517345122","DOIUrl":"https://doi.org/10.1073/pnas.2517345122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2517345122"},"PeriodicalIF":9.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Yang et al., How surface charges affect interdroplet freezing.","authors":"","doi":"10.1073/pnas.2517575122","DOIUrl":"https://doi.org/10.1073/pnas.2517575122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2517575122"},"PeriodicalIF":9.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brian Larkins, a plant science pioneer, leader, mentor, and friend.","authors":"Rebecca S Boston, M David Marks, Jerry D Cohen","doi":"10.1073/pnas.2515273122","DOIUrl":"https://doi.org/10.1073/pnas.2515273122","url":null,"abstract":"<p><p>Brian Larkins died in January 2025 at the age of 78 leaving a legacy of seminal scientific contributions that were fundamental to the establishment of the field of plant molecular biology. He elucidated the key processes in maize endosperm development and delivered technical breakthroughs in isolation of polysomes and translation of associated messenger RNAs. His models for protein body structure and his work to understand the molecular basis for restoring transparency to mutant maize seeds provided fundamental insights to improving nutritional quality of maize. Brian was an inspirational, beloved, and effective mentor to students, postdocs, and colleagues, leading by example and service. His visionary efforts during challenging financial times strengthened professional societies through exceptional fund-raising to support early career scientists thus providing a pathway for continued success.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2515273122"},"PeriodicalIF":9.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"QnAs with Blake C. Meyers.","authors":"Sandeep Ravindran","doi":"10.1073/pnas.2518195122","DOIUrl":"https://doi.org/10.1073/pnas.2518195122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2518195122"},"PeriodicalIF":9.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144754107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile of Sharon Y. Strauss.","authors":"Jennifer Viegas","doi":"10.1073/pnas.2517479122","DOIUrl":"https://doi.org/10.1073/pnas.2517479122","url":null,"abstract":"<p><p>Evolutionary ecologist Sharon Y. Strauss, an early proponent of unifying the fields of ecology and evolution, helped advance both disciplines. Now a distinguished emeritus professor at the University of California, Davis, Strauss remains active in research. One major focus of her work is using phylogenetic evolutionary history to understand current ecology, an approach applied to research reported in her Inaugural Article. Strauss et al. determined that certain plant species may be less adaptable than expected to climate change. The finding holds widespread implications for conservation and management.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2517479122"},"PeriodicalIF":9.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Clegg and Gross, Cross-feeding creates tipping points in microbiome diversity.","authors":"","doi":"10.1073/pnas.2517344122","DOIUrl":"https://doi.org/10.1073/pnas.2517344122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2517344122"},"PeriodicalIF":9.4,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction for Das et al., Mycobacteriophage-mediated gene transfer enables in vitro drug screening and in vivo tracking of <i>Mycobacterium leprae</i>.","authors":"","doi":"10.1073/pnas.2517475122","DOIUrl":"10.1073/pnas.2517475122","url":null,"abstract":"","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"122 31","pages":"e2517475122"},"PeriodicalIF":9.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trauma-predictive brain network connectivity adaptively responds to mild acute stress","authors":"Felicia A. Hardi, Jean Ye, Irene Zhou, Zihan Bai, D. T. Nguyen, Krystian B. Loetscher, Julia G. Pratt, Bailey B. Harris, Dylan G. Gee, Elizabeth V. Goldfarb","doi":"10.1073/pnas.2505965122","DOIUrl":"https://doi.org/10.1073/pnas.2505965122","url":null,"abstract":"Past traumatic experiences shape neural responses to future stress, but the mechanisms underlying this dynamic interaction remain unclear. Here, we assessed how trauma-related brain networks respond to current acute stress in real time. Using a machine learning approach, we trained and tested brain functional connectivity networks to predict past trauma exposure in a community sample of adults ( <jats:italic toggle=\"yes\">N</jats:italic> = 170). We then evaluated the response of these trauma-predictive brain networks to an acute emotional and physiological stressor in a subsample of participants ( <jats:italic toggle=\"yes\">N</jats:italic> = 92) and to a pharmacological manipulation (hydrocortisone) in an independent crossover study ( <jats:italic toggle=\"yes\">N</jats:italic> = 27). We found that connectome-based predictive modeling successfully predicted past trauma exposure. The network associated with greater trauma exposure showed high involvement of salience network connections, with model prediction driven by connectivity in the medial frontal cortex, salience network, motor regions, default mode network, and cerebellum. Notably, connectivity in this trauma-predictive network was significantly attenuated following an acute stressor relative to control. A similar pattern was observed in the pharmacology sample, with decreased connectivity under hydrocortisone compared to placebo within this trauma-predictive network. Finally, attenuated trauma-predictive network connectivity after acute stress was associated with lower depressive symptoms in the stress-exposed group, but not control group. These findings suggest that stress may induce blunted connectivity of brain networks related to past traumatic experiences and that the reduced engagement of these trauma-predictive brain networks may facilitate adaptive regulatory response to later stress.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"111 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybridization of molecules via a common photonic mode","authors":"Jahangir Nobakht, André Pscherer, Jan Renger, Stephan Götzinger, Vahid Sandoghdar","doi":"10.1073/pnas.2505161122","DOIUrl":"https://doi.org/10.1073/pnas.2505161122","url":null,"abstract":"Atoms and molecules usually hybridize and form bonds when they come in very close proximity of each other. In this work, we show that molecules can hybridize even through far-field electromagnetic interactions mediated by the shared mode of an optical microcavity. We discuss a collective enhancement of the vacuum Rabi splitting and study super- and subradiant states that arise from the cavity-mediated coupling both in the resonant and dispersive regimes. Moreover, we demonstrate a two-photon transition that emerges between the ground and excited states of the new optical compound. Our experimental data are in excellent agreement with the predictions of the Tavis–Cummings Hamiltonian and open the door to the realization of hybrid light–matter materials.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"52 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DICER-LIKE 5 loss causes thermosensitive male sterility in durum wheat and reveals an AU-rich motif guiding 24-nt phasiRNA biogenesis","authors":"Sébastien Bélanger, Azahara C. Martín, D. Blaine Marchant, Junpeng Zhan, Madison McGregor, Mark Smedley, Sadiye Hayta, Graham Moore, Blake C. Meyers","doi":"10.1073/pnas.2504349122","DOIUrl":"https://doi.org/10.1073/pnas.2504349122","url":null,"abstract":"Reproductive, male-enriched small RNAs are present in flowering plants and animals, yet their role in plants remains underexplored. We generated <jats:italic toggle=\"yes\">dicer-like 5</jats:italic> ( <jats:italic toggle=\"yes\">dcl5</jats:italic> ) mutants in durum wheat ( <jats:italic toggle=\"yes\">Triticum turgidum</jats:italic> ssp. <jats:italic toggle=\"yes\">durum</jats:italic> 2n = 4× = 28; AABB), revealing temperature-sensitive genic male sterility. Loss of <jats:italic toggle=\"yes\">DCL5</jats:italic> depleted premeiotic and meiotic 24-nt phasiRNA production, correlating with sterility under standard growth conditions and partial fertility recovery at higher temperatures. A single functional <jats:italic toggle=\"yes\">DCL5</jats:italic> allele restored complete fertility, presenting a promising alternative to current methods for hybrid production. We demonstrate that premeiotic 24-nt phasiRNA biogenesis is independent of miRNA-mediated cleavage and driven by a conserved motif initiating DCL5 activity. In the <jats:italic toggle=\"yes\">dcl5</jats:italic> mutant developing under sterility-inducing conditions, developmental defects are observed during pollen maturation, rather than at peak 24-nt phasiRNA accumulation in premeiotic and meiotic anthers. Although no visible morphological abnormalities were apparent during early development, single-cell RNA sequencing revealed that <jats:italic toggle=\"yes\">dcl5</jats:italic> mutant cells exhibit transcriptional profiles distinct from those of wild-type cells, when premeiotic 24-nt phasiRNAs are accumulating at the early developmental stage. Finally, the coexpression of <jats:italic toggle=\"yes\">Argonaute</jats:italic> ( <jats:italic toggle=\"yes\">AGO1b</jats:italic> , <jats:italic toggle=\"yes\">AGO4a,</jats:italic> and <jats:italic toggle=\"yes\">AGO6</jats:italic> ) homeologs in 24-nt phasiRNA-producing cells identifies candidate effectors and suggests a role for 24-nt phasiRNAs in transcriptional gene silencing.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"20 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}