Proceedings of the National Academy of Sciences of the United States of America最新文献

{"title":"Layer-specific genetic variation unlocks secondary metabolite diversity in long-lived clonal peppermint.","authors":"Nestor Kippes, Meric C Lieberman, Darrin Culp, Isabelle J DeMarco, Helen T Tsai, Kanae Masuda, Niccolò Terzaroli, Jordan Lopez, Robert G Wilson, Luca Comai, Isabelle M Henry","doi":"10.1073/pnas.2532794123","DOIUrl":"https://doi.org/10.1073/pnas.2532794123","url":null,"abstract":"<p><p>Mutations that arise in the shoot apical meristems can become fixed, but typically only in one of the meristem layers. Therefore, in long-lived, clonally propagated species, polymorphic genomes coexist in the form of periclinal chimeras. Given their evolutionary and economic impact, it is critical to understand the dynamics and phenotypic implications of layer-specific variation. Here, we γ-irradiated axillary buds from an elite peppermint clone and obtained 261 independent mutants carrying large indels. We produced a haplotype-aware, high-continuity assembly of this sterile allohexaploid and, using short-read sequencing, detected, on average, six large indels per mutant. Importantly, most of these mutants were periclinal chimeras: comparison of mutation frequency in root (derived solely from the L2/3 layer) and leaves (which contain cells from all three layers) demonstrated that the indels are confined to either the outer, L1-derived layer, or the inner L2/3 layers. We observed that the L1 layer was more often mutated, confirming that mutation rate in the shoot apical meristem is potentially optimized to each meristematic layer. To assess whether deletion of a single haplotype in a single meristematic layer could affect plant function, we characterized mutants under field conditions, detecting variation in secondary metabolite production. Two mutants produced an oil with very low (-)-menthol levels, associated with the loss of a single haplotype of the menthone-menthol reductase gene in the epidermal layer. These results highlight the evolutionary relevance of layer-specific genetic variation and present opportunities for improvement of clonally propagated crops that suffer from genetic diversity bottlenecks.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 21","pages":"e2532794123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147856674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracing the origins and recurrence of the South Atlantic Anomaly: A 2000-year absolute paleointensity record from central South America.","authors":"Miriam Gómez-Paccard, F Javier Pavón-Carrasco, Annick Chauvin, Alicia Palencia-Ortas, Mercedes Rivero-Montero, Marina Puente-Borque, Saioa A Campuzano, Aída Adsuar, Raquel Bonilla-Alba, Judit Del Río, Regina Velázquez-Martín, María Luisa Osete, María Gabriela Ortíz, María Amalia Zaburlín, María Marta Sampietro-Vattuone, Diego Martín Basso, José Luis Peña-Monné, Clarisa Otero, Agustina Scaro","doi":"10.1073/pnas.2536503123","DOIUrl":"https://doi.org/10.1073/pnas.2536503123","url":null,"abstract":"<p><p>A robust characterization of geomagnetic field strength in the Southern Hemisphere over the past millennia is critical for understanding the (multi)centennial evolution of the South Atlantic Anomaly (SAA), one of the most prominent geomagnetic features at Earth's surface. Yet, robust absolute paleointensity records remain scarce in this region, introducing significant uncertainty into geomagnetic field reconstructions. Here, we present 41 absolute archeointensity determinations obtained using the Thellier-Thellier method from central South America spanning the last two millennia. Combined with a selection of high-quality records from the same region, these new data yield virtual axial dipole moment values broadly consistent with the other few available Southern Hemisphere datasets but generally lower than those from Europe, indicating a persistent north-south asymmetry in geomagnetic field strength. A new global geomagnetic field model incorporating these new data suggests that the observed asymmetry reflects a persistently northward-shifted eccentric dipole. In addition, the model tentatively suggests a westward migration of a nondipolar low-intensity anomaly between 1 and 850 CE, from the Indian Ocean to northern South America, following a trajectory broadly similar to that of the modern SAA, which appears in the Indian Ocean after 1100 CE and progresses across Africa before reaching South America. These findings support the hypothesis of a recurrent large-scale geomagnetic pattern and highlight multiscale geodynamic control on geomagnetic field morphology, in which mantle and core processes interact to shape secular variation patterns on centennial to millennial timescales.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2536503123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparate social structures are underpinned by distinct social rules across a primate radiation.","authors":"Jacob A Feder, Susan C Alberts, Elizabeth A Archie, Małgorzata E Arlet, Alice Baniel, Jacinta C Beehner, Thore J Bergman, Alecia J Carter, Marie J E Charpentier, Kenneth L Chiou, Catherine Crockford, Guy Cowlishaw, Federica Dal Pesco, David Fernández, Julia Fischer, James P Higham, Elise Huchard, Auriane Le Floch, Julia Lehmann, Amy Lu, Gráinne M McCabe, Alexander Mielke, Liza R Moscovice, Benjamin Mubemba, Megan Petersdorf, Caroline Ross, India A Schneider-Crease, Robert M Seyfarth, Noah Snyder-Mackler, Larissa Swedell, Franziska Trede, Jenny Tung, Anna H Weyher, Roman M Wittig, Jason M Kamilar, Joan B Silk","doi":"10.1073/pnas.2520774123","DOIUrl":"https://doi.org/10.1073/pnas.2520774123","url":null,"abstract":"<p><p>Over six decades of research on wild baboons and their close relatives (collectively, the African papionins) have uncovered substantial variation in their behavior and social systems. While most papionins form discrete social groups (single-level societies), a few others form small social units that are nested within larger supergroups (multi-level societies). These two systems are generally thought to be qualitatively distinct, but data from wild populations increasingly suggest that there may be areas of overlap. To quantify this potential gradient in social structure, a more systematic, comparative analysis is needed. Here, we constructed a database of behavioral and demographic records spanning 135 group-years, 28 social groups, 13 long-term field studies, and 11 species to quantify variation in grooming network structure and identify the individual and dyadic properties (e.g., kinship and social status effects) that underlie this variation. Consistent with accumulating field observations, the single-level species could be divided into two categories: <i>cohesive</i> and <i>cliquish</i>. Cohesive single-level networks were dense, kin-biased, and moderately rank-structured, while cliquish single-level networks were more differentiated, slightly more kin-biased, and strongly rank-structured. As expected, multi-level networks were very modular and shaped by females' ties to specific dominant males but varied in their kin biases. Taken together, these data suggest that in the African papionins i) kin and rank biases are widespread but vary in their strength; ii) male-centered subgroups are exclusive to multi-level systems; and iii) increases in network modularity can emerge in response to heightened nepotism and male-centered clustering.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2520774123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147819993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soil temperature fluctuations modulated millet agriculture evolution in Neolithic East Asia.","authors":"Yongxiu Lu, Jiaoyang Ruan, Ruiliang Liu, Jade d'Alpoim Guedes, Jixiao Wang, Yuanxin Li, Xin Wang, Yongxiang Xu, Liangcheng Tan, Jiahan Shang, Shugang Kang, Guanghui Dong","doi":"10.1073/pnas.2529151123","DOIUrl":"https://doi.org/10.1073/pnas.2529151123","url":null,"abstract":"<p><p>Millet agriculture was foundational to the emergence of complex societies in Neolithic East Asia, yet the environmental mechanisms shaping its spatiotemporal development remain unresolved. Here, we present a high-resolution reconstruction of Holocene growing-season soil temperature from biomarker proxies in a precisely dated loess sequence from the central Chinese Loess Plateau. Our data reveal a pronounced ~3 °C soil cooling between ~7.5 to 6.0 thousand years B.P. (kyr B.P.), followed by rapid warming and millennia-long relatively stable conditions. By integrating archaeological datasets with transient climate simulations, we show that this mid-Holocene soil cooling which reflects coupled climatic forcing and vegetation-related land surface changes likely compressed the thermally suitable niche for frost-sensitive millets, contributing to a southward displacement of cultivation and delaying large-scale agricultural expansion until the subsequent soil temperature recovery after ~6.0 kyr B.P. These findings suggest that large-amplitude soil temperature fluctuations acted as a modulating climatic constraint on the geographic distribution and development trajectory of millet agriculture in East Asia, providing refined insights into climate-society interactions during the Neolithic.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2529151123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choice of cardioplegia influences metabolomics of human cardiac tissue.","authors":"Sho Tanosaki, Yuan Zhang, Kenneth Bedi, Kenneth Margulies, James E Cox, Zoltan Arany, E Dale Abel","doi":"10.1073/pnas.2602039123","DOIUrl":"https://doi.org/10.1073/pnas.2602039123","url":null,"abstract":"<p><p>Cardioplegia is often used prior to acquisition of human cardiac tissue to minimize warm ischemia time, which can severely confound studies of cardiac metabolism. However, there are several choices of cardioplegia solutions, and whether these solutions differentially impact tissue metabolism or metabolomic studies is not known. Here, we perform untargeted metabolomics, using both liquid chromatography-mass spectrometry and gas chromatography-mass spectrometry, on a large cohort of hearts transplanted for cardiomyopathy or from gift-of-life donors, and who have received different cardioplegia solutions. We show that different cardioplegia solutions distinctly impact cardiac metabolism and tissue metabolomic studies. Notably, these differences are mild relative to those seen comparing failing to nonfailing hearts, and identification of cardioplegia components in mass spectra should enable rigorous interpretation of changes between conditions. These data demonstrate how cardioplegia solutions may influence cardiac metabolism in human heart samples and underscore the need to report specific details of cardioplegia solution use in studies of human cardiac metabolism.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2602039123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early evidence for a stable and flexible foraging niche in the evolution of <i>Homo</i>.","authors":"Frances Forrest, Eimy Gonzalez-Alvarez, Dan Palcu Rolier, Sharon Kuo, Matthew Skinner, Jonathan Reeves, Erin DiMaggio, Sarah Hlubik, Sahleselasie Melaku, Mathilde Ribordy, Alemu Gebresilassie Wolde, Emmanuel Ndiema, David R Braun","doi":"10.1073/pnas.2537631123","DOIUrl":"https://doi.org/10.1073/pnas.2537631123","url":null,"abstract":"<p><p>Major evolutionary transitions in <i>Homo</i> (e.g., increased brain size, complex social behavior) are linked to reliance on high-quality foods. Increased meat consumption likely contributed to this shift, but whether hominins practiced carcass acquisition and processing strategies consistently across time and environments remains unclear. The Koobi Fora Formation spans much of the Plio-Pleistocene and is central to reconstructing the ecology of early <i>Homo</i>. However, zooarchaeological research has focused almost entirely on the Okote Member (~1.56 to 1.38 Ma), while the KBS Member (~1.87 to 1.56 Ma) has yielded important hominin fossils but relatively few faunal assemblages comparably well preserved for similar analysis. We present an analysis of FwJj 80 (~1.6 Ma), an assemblage from the KBS Member that preserves butchered fauna associated with early <i>Homo</i> fossils. Results show that behaviors documented in the Okote Member, including early access to carcasses, selective transport of limbs, and systematic marrow extraction within riparian settings, were also practiced at FwJj 80. This provides the most comprehensive and systematically analyzed evidence of such behaviors within the KBS Member, demonstrating continuity in carcass-exploitation patterns between the KBS and Okote Members. Comparisons with FLK Zinj (~1.84 Ma, Tanzania) and Kanjera South (~2.0 Ma, Kenya) demonstrate a consistent foraging niche sustained across varied environmental contexts, underscoring behavioral flexibility as central to early <i>Homo'</i>s evolutionary success.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2537631123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic engineering of <i>Escherichia coli</i> for the biosynthesis of nylon 6 and nylon 6,6 monomers.","authors":"Da-Hee Ahn, Tong Un Chae, Sang Yup Lee","doi":"10.1073/pnas.2535786123","DOIUrl":"https://doi.org/10.1073/pnas.2535786123","url":null,"abstract":"<p><p>Hexamethylenediamine (HMD), adipic acid, and ε-caprolactam (ε-CL) are essential C6 monomers used in the production of nylon 6,6 and nylon 6. Developing sustainable, bio-based routes to these compounds remains challenging due to pathway complexity. Here, we report a modular <i>Escherichia coli</i> platform for the de novo biosynthesis of all three monomers directly from glycerol. We divided the overall pathway into upstream and downstream modules, with the upstream module converting glycerol to adipic acid. To construct downstream module, two distinct strains were engineered to individually convert adipic acid into HMD or ε-CL. Both strains employed carboxylic acid reductases Macar from <i>Mycobacteroides abscessus</i> and Mmocar from <i>Mycolicibacterium moriokaense</i>, with the latter identified and validated in this work. Specifically, HMD biosynthesis incorporated aminotransferases PatA from <i><i>E. coli</i></i>, GabT from <i><i>Streptomyces</i> avermitilis</i>, and the introduced Bcta from <i>Burkholderia cenocepacia</i>. ε-CL biosynthesis utilized a similar upstream pathway but relied critically on a lactamization step catalyzed by an HLadh-Smnox fusion enzyme containing a flexible linker for efficient NAD⁺ regeneration. The common precursor, adipic acid, was produced by an upstream strain optimized through reverse β-oxidation pathway reconstruction, PaaJ engineering, and metabolic flux balancing, achieving a titer of 6.1 g/L. In fed-batch fermentation, cocultivation of the engineered strains with delayed inoculation enabled temporally coordinated conversion of glycerol to HMD (230.9 mg/L) and ε-CL (808.0 µg/L), representing low yet the highest titers reported to date. This work opens up the possibility of a unified, modular microbial platform for the sustainable production of nylon monomers from a renewable carbon source.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 20","pages":"e2535786123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intramolecular bonding as a design strategy for robust intermolecular binding of oligomers.","authors":"Mohammed Suliman Alshammasi, R Kenton Weigel, Christopher A Alabi, Fernando A Escobedo","doi":"10.1073/pnas.2534579123","DOIUrl":"https://doi.org/10.1073/pnas.2534579123","url":null,"abstract":"<p><p>In this study, a combined multiscale-modeling and experimental framework is presented to elucidate design rules to optimize the binding thermodynamics and kinetics of sequence-defined oligomers. It is shown that, contrary to conventional notions, entropy can be designed to favor not only binding affinity but also the rapid hybridization of stable complementary complexes. This entropic gain of binding arises from a strategic interplay between intermolecular contacts and intramolecular interactions that maintain restricted oligomer conformations when unbound. Furthermore, our analysis underscores the important role that solvent quality plays in modulating this interplay through structural changes upon binding in both the oligomers and their solvation shells. While these insights are in principle chemistry-agnostic and can be deployed for a wide range of materials platforms and applications, oligocarbamates are used as testbeds for experimental validation. Oligocarbamates are economical DNA-mimics that, unlike DNA-based constructs, form stable Watson-Crick bonds in common nonaqueous solvents, are not susceptible to enzymatic degradation and can be economically produced at scale.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 19","pages":"e2534579123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAGA1 and SAGA2 localize the starch sheath to the pyrenoid in <i>Chlamydomonas reinhardtii</i>.","authors":"Victoria L Crans, Micah I Burton, Aastha Garde, Lianyong Wang, Martin C Jonikas","doi":"10.1073/pnas.2533609123","DOIUrl":"https://doi.org/10.1073/pnas.2533609123","url":null,"abstract":"<p><p>Most algae enhance their CO₂ assimilation by concentrating CO₂ within the pyrenoid, a biomolecular condensate of the CO₂-fixing enzyme Rubisco. Many pyrenoids are surrounded by a starch sheath thought to slow the escape of CO₂ from the pyrenoid, but how the starch sheath is localized to the pyrenoid remains poorly understood. Here, in the model alga <i>Chlamydomonas reinhardtii</i>, we find that the protein SAGA2 is necessary for early pyrenoid starch sheath biogenesis and works redundantly with its homolog, SAGA1, to localize the starch sheath to the pyrenoid. SAGA2 and SAGA1 were enriched in different regions of the pyrenoid-starch sheath interface: SAGA1 at pyrenoid tubule-associated puncta and SAGA2 along the rest of the interface, suggesting that SAGA2 and SAGA1 play complementary roles. Both <i>saga2</i> and <i>saga1</i> mutants showed decreased starch sheath coverage early during pyrenoid formation that was remedied at a later timepoint. Strikingly, a <i>saga1;saga2</i> double mutant did not have a starch sheath around the pyrenoid at any timepoint. SAGA1 and SAGA2 starch-binding domains bound to starch, the starch mimic β-cyclodextrin, and the starch precursor maltoheptaose, suggesting a role for SAGA1 and SAGA2 in starch granule initiation. We propose a model where SAGA1 and SAGA2 each locally prime starch sheath initiation in a distinct region of the pyrenoid surface by enriching starch precursor molecules around the pyrenoid. These findings advance the understanding of algal starch sheath biogenesis and provide insights into the associations between biomolecular condensates and other cellular structures.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 19","pages":"e2533609123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attention control ability is associated with frontoparietal control network interactions.","authors":"Dolly T Seeburger, Jason S Tsukahara, Nan Xu, Vishwadeep Ahluwalia, Shella D Keilholz, Randall W Engle","doi":"10.1073/pnas.2526828123","DOIUrl":"https://doi.org/10.1073/pnas.2526828123","url":null,"abstract":"<p><p>Attention control predicts academic achievement, professional success, and health outcomes. However, the neural basis of stable, individual differences in attention control remains unclear. Prior research has emphasized momentary fluctuations in attentional engagement, often overlooking enduring individual differences. Here, we applied the quasi-periodic pattern analysis of infraslow functional magnetic resonance imaging (fMRI) dynamics in a large sample (<i>N</i> = 196) to test whether trait attention control is reflected in network-level brain activity as well as the locus coeruleus (LC). Using latent-variable measures of attention control, working memory capacity, and fluid intelligence, we isolated the unique contribution of attention control across rest, 1-back, and 3-back conditions. As cognitive demand increased, individuals with higher attention control exhibited more coordinated activity of the frontoparietal control network (FPCN): they showed enhanced coupling with the dorsal attention network (DAN), and greater engagement with the LC and stronger decoupling from the default mode network (DMN). Even at rest, high attention individuals demonstrated stronger FPCN-DAN coupling and little to no correlation between FPCN-DMN, indicating that attentional capacity is reflected in both task-evoked reconfiguration and baseline network architecture. These findings reveal how attention control, as an ability, is instantiated in the brain's dynamic architecture.</p>","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"123 19","pages":"e2526828123"},"PeriodicalIF":9.1,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147841961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}