Proceedings of the National Academy of Sciences of the United States of America最新文献_第10页

Spatiotemporal decoupling of floristic endemism in response to Qinghai-Tibet Plateau uplift. 青藏高原隆升对植物区系特有的时空解耦响应。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-21 DOI: 10.1073/pnas.2513876122

Bao Yang,Xuelian Wang

引用次数: 0

Correction to Supporting Information for Seigneur et al., Cbln2 and Cbln4 are expressed in distinct medial habenula-interpeduncular projections and contribute to different behavioral outputs. 对Seigneur等人的支持信息的更正，Cbln2和Cbln4在不同的内侧束间突起中表达，并导致不同的行为输出。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-21 DOI: 10.1073/pnas.2516923122

引用次数: 0

Optimistic people are all alike: Shared neural representations supporting episodic future thinking among optimistic individuals 乐观的人都是相似的：乐观的人有共同的神经表征，支持情景未来思维

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-21 DOI: 10.1073/pnas.2511101122

Kuniaki Yanagisawa, Ryusuke Nakai, Kohei Asano, Emiko S. Kashima, Hitomi Sugiura, Nobuhito Abe

{"title":"Optimistic people are all alike: Shared neural representations supporting episodic future thinking among optimistic individuals","authors":"Kuniaki Yanagisawa, Ryusuke Nakai, Kohei Asano, Emiko S. Kashima, Hitomi Sugiura, Nobuhito Abe","doi":"10.1073/pnas.2511101122","DOIUrl":"https://doi.org/10.1073/pnas.2511101122","url":null,"abstract":"Optimism is a critical personality trait that influences future-oriented cognition by emphasizing positive future outcomes and deemphasizing negative outcomes. How does the brain represent idiosyncratic differences in episodic future thinking that are modulated by optimism? In two functional MRI (fMRI) studies, participants were scanned during an episodic future thinking task in which they were presented with a series of episodic scenarios with different emotional valence and prompted to imagine themself (or their partner) in the situation. Intersubject representational similarity analysis revealed that more optimistic individuals had similar neural representations in the medial prefrontal cortex (MPFC), while less optimistic individuals exhibited more idiosyncratic neural representations in the MPFC. Additionally, individual difference multidimensional scaling of MPFC activity revealed that the referential target and emotional valence of imagined events were clearly mapped onto different dimensions. Notably, the weights along the emotional dimension were closely linked to the optimism scores of participants, suggesting that optimistic individuals imagine positive events as more distinct from negative events. These results suggest that shared neural processing of the MPFC among optimistic individuals supports episodic future thinking that facilitates psychological differentiation between positive and negative future events.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"97 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition Angelman综合征的临床前猪模型反映了人类病情的早期发育轨迹

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-21 DOI: 10.1073/pnas.2505152122

Luke S. Myers, Sarah G. Christian, Sean Simpson, Renan Sper, Clint Taylor, Laura Montes, Thomas B. C. Jepp, Daniela Ramos, Livia Schuller, Kranti Konganti, Wade Friedeck, Ozair Habib, McKaela Hodge, Alasdair J. Taylor, Ashley Coffell, Annalise Schlafer, Morgan Matt, Bradley Revell, Carol Knight, Cristina C. Barreña, William J. Murphy, Edwin J. Weeber, David J. Segal, Anne Anderson, Kevin R. Nash, Jill L. Silverman, Jorge A. Piedrahita, Scott V. Dindot

{"title":"A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition","authors":"Luke S. Myers, Sarah G. Christian, Sean Simpson, Renan Sper, Clint Taylor, Laura Montes, Thomas B. C. Jepp, Daniela Ramos, Livia Schuller, Kranti Konganti, Wade Friedeck, Ozair Habib, McKaela Hodge, Alasdair J. Taylor, Ashley Coffell, Annalise Schlafer, Morgan Matt, Bradley Revell, Carol Knight, Cristina C. Barreña, William J. Murphy, Edwin J. Weeber, David J. Segal, Anne Anderson, Kevin R. Nash, Jill L. Silverman, Jorge A. Piedrahita, Scott V. Dindot","doi":"10.1073/pnas.2505152122","DOIUrl":"https://doi.org/10.1073/pnas.2505152122","url":null,"abstract":"Angelman syndrome is a neurodevelopmental disorder characterized by severe motor and cognitive deficits. It is caused by the loss of the maternally inherited allele of the imprinted ubiquitin-protein ligase E3A ( UBE3A ) gene. Rodent models of Angelman syndrome do not fully recapitulate all the symptoms associated with the condition and are limited as a preclinical model for therapeutic development. Here, we show that pigs ( Sus scrofa ) with a maternally inherited deletion of UBE3A ( UBE3A -/+ ) have altered postnatal behaviors, impaired vocalizations, reduced brain growth, motor incoordination, and ataxia. Neonatal UBE3A -/+ pigs exhibited several symptoms observed in infants with Angelman syndrome, including hypotonia, suckling deficits, and failure to thrive. Collectively, these findings are consistent with the pathophysiology and developmental trajectory observed in individuals with Angelman syndrome. We anticipate that this pig model will advance our understanding of the pathophysiology of Angelman syndrome and be used as a preclinical large animal model for therapeutic development.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"45 1","pages":""},"PeriodicalIF":11.1,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ancient immune pathway enables animal metamorphosis. 一种古老的免疫途径使动物得以变形。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-21 DOI: 10.1073/pnas.2512734122

Elizabeth Heath-Heckman

引用次数: 0

Optimizing the application order under precedent-based decision-making. 基于先例决策的应用顺序优化。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-18 DOI: 10.1073/pnas.2509985122

Rossella Argenziano,Itzhak Gilboa

引用次数: 0

Block copolymer molecular design to address practical limitations to recycling polyolefin blends. 嵌段共聚物分子设计，以解决回收聚烯烃共混物的实际限制。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-18 DOI: 10.1073/pnas.2508921122

Shuquan Cui,Daun Jeong,Yukai Shi,Nusrat Jahan,Timothy P Lodge,Frank S Bates,Christopher J Ellison

{"title":"Block copolymer molecular design to address practical limitations to recycling polyolefin blends.","authors":"Shuquan Cui,Daun Jeong,Yukai Shi,Nusrat Jahan,Timothy P Lodge,Frank S Bates,Christopher J Ellison","doi":"10.1073/pnas.2508921122","DOIUrl":"https://doi.org/10.1073/pnas.2508921122","url":null,"abstract":"Plastics offer innumerable societal benefits but simultaneously contribute to persistent environmental pollution, dominated by polyethylene (PE) and isotactic polypropylene (iPP). Melt blending and reformulating postconsumer PE and iPP into useful materials presents a promising recycling approach. However, such repurposed plastics are generally mechanically inferior due to an inability to efficiently separate polyolefins in mixed waste streams; phase separation of PE and iPP results in brittleness as a consequence of poor interfacial strength. Recently, we demonstrated that a small amount (1 wt%) of a poly(ethylene)-block-poly(ethyl ethylene-ran-ethylene)-block-poly(ethylene) (EXE) triblock copolymer, synthesized by low-cost anionic polymerization of 1,3-butadiene followed by solution hydrogenation, restores tensile toughness to levels equivalent to virgin polyolefins. Unfortunately, low-temperature solvent insolubility of EXE, driven by crystallization of the E blocks containing 1.5 ethyl branches per 100 backbone repeat units (EB), presents a challenge for industrial hydrogenation. Comparable toughness (ca. > 400% strain at break) was achieved in the present work with 1.5 ≤ EB ≤ 6.5, accompanied by reduced EXE crystallinity and dissolution in cyclohexane down to room temperature at the highest EB content. This remarkable toughening behavior is attributed to a synergy between chain entanglements between the E end blocks and semicrystalline PE homopolymer and formation of E block \"crystal nodules\" that prevent chain pullout, along with topological constraints between the X loops and semicrystalline iPP. Our findings overcome barriers to commercial production of EXE with existing industrial facilities, providing a cost-effective strategy for recycling PE and iPP.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"20 1","pages":"e2508921122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction for Spirandelli et al., Exotic self-assembly of hard spheres in a morphometric solvent. 对Spirandelli等人的修正，硬球在形态计量溶剂中的外来自组装。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-18 DOI: 10.1073/pnas.2516290122

引用次数: 0

Correction for Beal et al., Nutrient-dense foods and diverse diets are important for ensuring adequate nutrition across the life course. 营养丰富的食物和多样化的饮食对于确保整个生命过程中充足的营养是很重要的。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-18 DOI: 10.1073/pnas.2516301122

引用次数: 0

Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags. 硫醚编辑通常会增加罗丹明染料在自标记标签上的光稳定性。

IF 11.1 1区综合性期刊

Proceedings of the National Academy of Sciences of the United States of America Pub Date : 2025-07-18 DOI: 10.1073/pnas.2426354122

Jing Ling,Yuan Zhang,Yongzhen Hei,Julian Kompa,Chen Yang,Bo Wang,Junwei Zhang,Jiasheng Du,Tatjana Rudi,Kecheng Zhang,Jingfu Sun,Wenjuan Wang,Sebastian Fabritz,Yulong Li,Wulan Deng,Peng Zou,Chunlai Chen,Zhixing Chen

{"title":"Thioether editing generally increases the photostability of rhodamine dyes on self-labeling tags.","authors":"Jing Ling,Yuan Zhang,Yongzhen Hei,Julian Kompa,Chen Yang,Bo Wang,Junwei Zhang,Jiasheng Du,Tatjana Rudi,Kecheng Zhang,Jingfu Sun,Wenjuan Wang,Sebastian Fabritz,Yulong Li,Wulan Deng,Peng Zou,Chunlai Chen,Zhixing Chen","doi":"10.1073/pnas.2426354122","DOIUrl":"https://doi.org/10.1073/pnas.2426354122","url":null,"abstract":"Self-labeling protein tags are widely used in advanced bioimaging where dyes with high-photon budgets outperform their fluorescent protein counterparts. Further increasing the emitted photon numbers of dye-tag systems is actively pursued by both new fluorophore chemistry and protein engineering. By scrutinizing the protein microenvironment of fluorophores, here we propose that proximal thioether groups negatively affect the photostability of the dye-tag system. We attribute the disparity in photostability of rhodamine dyes on HaloTag, SNAP-tag, and TMP-tag3 to the influence of the inherent thioether linkage within the SNAP-tag and TMP-tag3. This photochemical pathway leads us to further devise tags with higher photostability. We first show that rhodamine dyes on TMP-tag3.1, which employs a proximity-induced SuFEx reaction instead of a thiol-acrylamide addition to replace the thioether adduct, achieve photon budgets comparable to those ligands on HaloTag. We further showcase that by mutating the methionine near the fluorophore pocket, HaloTag: M175L generally gives up to four times enhancement on photostability when labeled with red and far-red rhodamines. The enhancement of HaloTag modification is demonstrated with single-molecule fluorescence imaging, live-cell fluorescence imaging, and voltage imaging. During time-lapse imaging, gradual photooxidation of Met leads to a reduced photobleaching rate, mechanistically supporting the thioether pathway hypothesis. Our findings suggest that thioether editing on self-labeling tags is a general strategy to enhance the photostability of fluorophores for advanced time-lapse imaging techniques.","PeriodicalId":20548,"journal":{"name":"Proceedings of the National Academy of Sciences of the United States of America","volume":"13 1","pages":"e2426354122"},"PeriodicalIF":11.1,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0