IF 11 1区综合性期刊

Research Pub Date : 2025-07-24 eCollection Date: 2025-01-01 DOI: 10.34133/research.0779

Zimo Cai, Kangjie Ye, Huayu Luo, Jian Tang, Geng Yang, Haibo Xie, Huayong Yang, Kaichen Xu

{"title":"Textile Hybrid Electronics for Multifunctional Wearable Integrated Systems.","authors":"Zimo Cai, Kangjie Ye, Huayu Luo, Jian Tang, Geng Yang, Haibo Xie, Huayong Yang, Kaichen Xu","doi":"10.34133/research.0779","DOIUrl":"https://doi.org/10.34133/research.0779","url":null,"abstract":"Textiles with intrinsic breathability and mechanical adaptability are revolutionizing wearable electronics by delivering outstanding comfort and integration potentials. However, the expanding functionalities and body coverage of textile electronics necessitate large-scale and distributed driving circuits, which typically compromise the flexibility and permeability of textiles. To overcome the limitations of traditional circuit boards, textile hybrid electronics (THE) have emerged as promising electronic platforms, where both flexible and rigid components are seamlessly integrated into textiles. This route offers a synergy of system-level performance and wearing comfort. The progress report presents a comprehensive overview of the fabrication strategies for fully integrated THE, mainly encompassing the cross-scale production of flexible components and the reliable integration of rigid components. First, typical materials classified in textile electronic components are summarized. Then, various methods for constructing flexible coatings and fibrous structures are elucidated with distinct mechanisms and advantages for textile substrates. Followed by that, the focus shifts to the heterogeneous integration of rigid components, including the layer-by-layer and in-fiber strategies. Both approaches show promise in realizing monolithic and untethered THE systems. Furthermore, representative paradigms of THE are presented for their applications in pervasive health management and human-machine interaction. Finally, future trends of THE toward distributed and intelligent systems are specially emphasized, with key challenges and potential solutions outlined. The combination of various forms of THE is expected to embed advanced electronic functionalities into everyday textiles, bridging the gap between wearable electronics and human life.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0779"},"PeriodicalIF":11.0,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12287603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multifunctional Au-Ag-Cr Nanocomposites: From Multiplex Sensing and Advanced Logic Computing to Scalable Information Protection. 多功能Au-Ag-Cr纳米复合材料：从多路传感和高级逻辑计算到可扩展的信息保护。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.34133/research.0763

Jie Zhou, Jiao Yang Lu, Zhi Xin Xie, Dong Hua Wang, Bin Sheng He, Wei Tao Huang

{"title":"Multifunctional Au-Ag-Cr Nanocomposites: From Multiplex Sensing and Advanced Logic Computing to Scalable Information Protection.","authors":"Jie Zhou, Jiao Yang Lu, Zhi Xin Xie, Dong Hua Wang, Bin Sheng He, Wei Tao Huang","doi":"10.34133/research.0763","DOIUrl":"10.34133/research.0763","url":null,"abstract":"Polymetallic nanomaterials have important development potential by integrating the properties and advantages of their components. However, their preparation paradigm urgently needs to be updated to make full use of their characteristics to realize their multifaceted applications. In this study, multifunctional trimetallic gold-silver-chromium nanocomposites (Au-Ag-Cr NCs) were successfully synthesized, and their polymetallic plasmonic absorption properties were used in a variety of applications, from multimode and multianalyte sensing, advanced arithmetic, and reversible logic to long-text information protection. Au-Ag-Cr NCs with Au or Ag nanoparticles anchored on Cr nanobelts were synthesized using Au-Cr nanoseeds, Ag+, ascorbic acid as the reductant, and sodium dodecylbenzenesulfonate as the stabilizer. The resulting Au-Ag-Cr NCs exhibited multichannel sensing ability for 2 analytes (Hg2+ and hypochlorite), with remarkably improved selectivity and sensitivity when analyzing combined channels. Multiresponsiveness of Au-Ag-Cr NCs to diverse substance combinations underpins input-output mapping relationships, enabling advanced molecular logic computations (such as arithmetic and reversible logic). By digitizing its intrinsic sensing and response mechanisms, advanced molecular information protection (including encoding, encryption, and information concealment) for extended text were successfully implemented. This work not only offers novel insights into the design and multifunctionality of multicomponent nanocomposites but also paves the way for a new paradigm in molecular information technology that integrates sensing, logic processing, and information security.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0763"},"PeriodicalIF":11.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Situ Pixel-Scale Magnetic Programming 3-Dimensional Printing for Multimode Soft Miniature Robots with Multifunctions. 多模多功能软微型机器人的原位像素级磁编程三维打印。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.34133/research.0734

Song Zhao, Liwen Zhang, Kuntao Tan, Shengbin Zhang, Botao Ma, Xueshan Jing, Xinzhao Zhou, Yan Wang, Huawei Chen

{"title":"In Situ Pixel-Scale Magnetic Programming 3-Dimensional Printing for Multimode Soft Miniature Robots with Multifunctions.","authors":"Song Zhao, Liwen Zhang, Kuntao Tan, Shengbin Zhang, Botao Ma, Xueshan Jing, Xinzhao Zhou, Yan Wang, Huawei Chen","doi":"10.34133/research.0734","DOIUrl":"10.34133/research.0734","url":null,"abstract":"Magnetic microrobots with noncontact and real-time control capabilities have garnered marked attention for targeted drug delivery in narrow, enclosed pathways within the human body. The manufacturing method of these magnetic robots plays a crucial role in determining their functionality. In this study, a photocuring 3-dimensional (3D) printing technique with in situ pixel-scale magnetic programming was developed, enabled by a 3D large-scale uniform magnetic field generator with a high strength of approximately 50 mT. Magnetic particles were rotated and aligned on demand to print intelligent structures with a spatial resolution of 50 μm. A novel key-node splicing magnetization method was introduced to control multicurved deformations in 1D strips and 2D membrane magnetic robots, enabling various modes of locomotion, such as rolling, creeping, swimming, and patch-based drug release. To support additional functions, 3D spatial magnetization was implemented for customized spiral capsule robots, allowing precise multidirectional swimming and multitarget droplet-based drug delivery. These multimode and multifunctional magnetic actuators were validated through in vivo operations in confined environments such as the gastrointestinal tract and bladder.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0734"},"PeriodicalIF":11.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12282394/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic Multi-Image Weighting for Automated Detection and Diagnosis of Abnormal Urinary Tract on Voiding Cystourethrography with a Deep Learning System: A Retrospective, Large-Scale, Multicenter Study. 基于深度学习系统的动态多图像加权用于排尿膀胱尿道造影异常尿路自动检测和诊断：一项回顾性、大规模、多中心的研究。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.34133/research.0771

Min Wu, Zhanchi Li, YiDong Liu, Zelong Tan, Wenjuan Tang, Xiaoqi Xuan, Hui Feng, Weihua Lao, Ning Ding, BoJun Wang, Zheyuan Wang, Likai Zhuang

{"title":"Dynamic Multi-Image Weighting for Automated Detection and Diagnosis of Abnormal Urinary Tract on Voiding Cystourethrography with a Deep Learning System: A Retrospective, Large-Scale, Multicenter Study.","authors":"Min Wu, Zhanchi Li, YiDong Liu, Zelong Tan, Wenjuan Tang, Xiaoqi Xuan, Hui Feng, Weihua Lao, Ning Ding, BoJun Wang, Zheyuan Wang, Likai Zhuang","doi":"10.34133/research.0771","DOIUrl":"10.34133/research.0771","url":null,"abstract":"We aimed to develop a voiding cystourethrography (VCUG) diagnostic artificial intelligence model (VCUG-DAM), which relies on a novel architecture to automatically segment and diagnose the bladder, urethra, and ureters using a single VCUG image, while dynamically assessing the relative importance of each image. A total of 7,899 VCUG images from 1,660 patients across 15 Chinese hospitals were collected between 2021 and 2023. In stage 1, we assessed the performances of the VCUG-DAM model. The patient-level area under the curve (AUC) of VCUG-DAM was 0.8772, 0.7752, 0.9443, and 0.9342 for bladder, urethral, left, and right vesicoureteral reflux (VUR), respectively. In stage 2, we explored whether the VCUG-DAM model could improve the diagnostic ability of clinicians. VCUG-DAM improved the clinician's diagnostic performance, with mean AUCs increasing from 0.8185 to 0.9456 for the bladder, 0.6507 to 0.7943 for the urethra, 0.6288 to 0.9641 for the left VUR, and 0.7305 to 0.9506 for the right VUR (all P < 0.0001). In stage 3, the consistency of the VCUG-DAM for VUR grading was validated. VCUG-DAM improved inter-clinician agreement for VUR grading. The fully automated VCUG-DAM demonstrated high accuracy, reliability, and robustness in multitask diagnoses of urinary tract abnormalities across multiple VCUG images, while improving the diagnostic ability of clinicians as an auxiliary tool.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0771"},"PeriodicalIF":11.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis. visomittin通过STAT3/LDHB轴重编程破骨细胞代谢减轻病理性骨丢失。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-22 eCollection Date: 2025-01-01 DOI: 10.34133/research.0784

Putao Yuan, Zhenhua Feng, Haotian Yang, Hong Xue, Hongwei Xie, Zihan Dai, Haoming Wang, Ying Liu, Bin Pan, Hongpu Song, Huali Ye, Ziang Xie, Peihua Shi, Xuewu Sun

{"title":"Visomitin Attenuates Pathological Bone Loss by Reprogramming Osteoclast Metabolism via the STAT3/LDHB Axis.","authors":"Putao Yuan, Zhenhua Feng, Haotian Yang, Hong Xue, Hongwei Xie, Zihan Dai, Haoming Wang, Ying Liu, Bin Pan, Hongpu Song, Huali Ye, Ziang Xie, Peihua Shi, Xuewu Sun","doi":"10.34133/research.0784","DOIUrl":"10.34133/research.0784","url":null,"abstract":"A persistently substantial energy demand and metabolic reprogramming endure throughout the entire course of osteoclastogenesis, accompanied by an intensified oxidative stress. Hence, balancing cellular energy metabolism and maintaining redox homeostasis offer potential for coordinating osteoclastogenesis and bone loss in pathological conditions. In the present study, we have discovered Visomitin, a novel antioxidant that specifically targets mitochondria, which efficiently decreases intracellular reactive oxygen species (ROS) levels, inhibits osteoclastogenesis, and impairs the function of bone resorption. Mechanistically, Visomitin directly targets signal transducer and activator of transcription 3 (STAT3), leading to the inhibition of its transcriptional activity and modulation of lactate dehydrogenase B (LDHB) expression levels, consequently triggering metabolic reprogramming and exerting antagonistic effects on osteoclasts. Furthermore, administration of Visomitin demonstrates marked protective effects against pathological bone loss in vivo. Given its established clinical safety profile in ophthalmologic applications, Visomitin emerges as a promising anti-resorptive agent for clinical translation. This study also unveils the STAT3/LDHB axis as a critical nexus linking mitochondrial redox regulation to osteoclast metabolism, providing a novel therapeutic strategy for osteoclast-driven bone diseases.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0784"},"PeriodicalIF":11.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12280330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144691342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 11 1区综合性期刊

Research Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI: 10.34133/research.0783

Elena Corbetta, Thomas Bocklitz

{"title":"Multi-marker Similarity Enables Reduced-Reference and Interpretable Image Quality Assessment in Optical Microscopy.","authors":"Elena Corbetta, Thomas Bocklitz","doi":"10.34133/research.0783","DOIUrl":"10.34133/research.0783","url":null,"abstract":"Optical microscopy contributes to the ever-increasing progress in biological and biomedical studies, as it allows the implementation of minimally invasive experimental pipelines to translate the data of measured samples into valuable knowledge. Within these pipelines, reliable quality assessment must be ensured to validate the generated results. Image quality assessment is often applied with full-reference methods to estimate the similarity between the ground truth and the output images. However, current methods often show poor agreement with visual perception and lead to the generation of various full-reference metrics tailored to specific applications. Additionally, they rely on pixel-wise comparisons, emphasizing local intensity similarity while often overlooking comprehensive and interpretable image quality assessment. To address these issues, we have developed a multi-marker similarity method that compares standard quality markers, such as resolution, signal-to-noise ratio, contrast, and high-frequency components. The method computes a similarity score between the image and the ground truth for each marker and then combines these scores into an overall similarity estimate. This provides a full-reference estimate of image quality while extracting global quality features and detecting experimental artifacts. Multi-marker similarity provides a reliable and interpretable method for image quality assessment and the generation of quality rankings. By focusing on the comparison of quality markers rather than direct image distances, the method enables reduced-reference implementations, where a single field of view is used as a benchmark for multiple measurements. This opens a way for reliable automatic evaluation of big datasets, typical of large biomedical studies, when manually assessing single images and defining the ground truth for each field of view is not feasible.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0783"},"PeriodicalIF":11.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic Alopecia. 强大的二甲双胍纳米系统促进雄激素性脱发的头发生长。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-18 eCollection Date: 2025-01-01 DOI: 10.34133/research.0780

Qiuying Mai, Weisen Lin, Xiaoyu Qin, Guowang Cheng, Chen Wang, Guangtao Yu, Tongkai Chen

{"title":"Robust Metformin Nanosystem Promotes Hair Growth in Androgenetic Alopecia.","authors":"Qiuying Mai, Weisen Lin, Xiaoyu Qin, Guowang Cheng, Chen Wang, Guangtao Yu, Tongkai Chen","doi":"10.34133/research.0780","DOIUrl":"10.34133/research.0780","url":null,"abstract":"Androgenetic alopecia (AGA)-a condition characterized by hair loss due to aging, autoimmune responses, stress, and other factors-results in hair follicle (HF) shrinkage and dermal papilla cell apoptosis. So far, only minoxidil (MXD) and finasteride have been approved for AGA treatment. However, both drugs have serious side effects, including hypersensitivity and sexual dysfunction. Hence, novel treatment agents are required for AGA. Although metformin (Met) is primarily a diabetes drug, it is also known to promote hair growth. However, it shows low transdermal permeability, and the mechanisms underlying its therapeutic effects on AGA remain unclear. Two-dimensional black phosphorus nanosheets (BP NSs) have attracted attention as drug carriers due to their low cytotoxicity, good biocompatibility, and strong antioxidant capacity. However, they are unstable, prone to degradation, and unsuitable for transdermal drug delivery. Fortunately, this limitation can be addressed through modification strategies, such as polyethylene glycol (PEG) addition (PEGylation). Here, we PEGylated BP NSs to improve their stability and loaded them with Met to generate a transdermal system (BP-PEG-Met) for AGA treatment. Compared with topical MXD, BP-PEG-Met markedly promoted hair regeneration while inducing fewer side effects. BP-PEG-Met scavenged excessive reactive oxygen species in skin cells, reducing the oxidative stress around HFs. Moreover, it up-regulated the expression of vascular endothelial growth factor (VEGF) and platelet-endothelial cell adhesion molecule-1 (CD31) in dermal papillae, inducing angiogenesis around HFs and accelerating the hair cycle toward anagen. Overall, this BP-PEG-Met transdermal delivery system showed marked clinical potential as a multifunctional tool for treating alopecia and possibly managing other skin conditions.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0780"},"PeriodicalIF":11.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144675571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Broad-Spectrum Virus Elimination by Nasal Mucosa-Colonized Wild-Type Bacillus subtilis. 鼻黏膜定殖野生型枯草芽孢杆菌的广谱病毒清除。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-17 eCollection Date: 2025-01-01 DOI: 10.34133/research.0781

Yuchen Li, Chengjie Yang, Rongfeng Tang, Chengcheng Wang, Yunfeng Li, Wenwen Chao, Ahui Cui, Chun Liang, Ying Duan, Hui Zeng, Qian Yang

{"title":"Broad-Spectrum Virus Elimination by Nasal Mucosa-Colonized Wild-Type Bacillus subtilis.","authors":"Yuchen Li, Chengjie Yang, Rongfeng Tang, Chengcheng Wang, Yunfeng Li, Wenwen Chao, Ahui Cui, Chun Liang, Ying Duan, Hui Zeng, Qian Yang","doi":"10.34133/research.0781","DOIUrl":"10.34133/research.0781","url":null,"abstract":"Outbreaks and the widespread prevalence of porcine respiratory infectious diseases have led to substantial economic losses worldwide. In this study, epidemiological surveillance revealed lower viral detection in association with an increased abundance of Bacillaceae in pigs with outdoor access; thus, Bacillus subtilis NS12, a strain with enhanced mucosal colonization and superior broad-spectrum antiviral activity, was isolated from the nasal mucosa of these pigs for further investigation. This mechanistic study revealed that the antiviral efficacy of B. subtilis NS12 is primarily attributed to bioactive metabolites, including a novel surfactin with high safety and antiviral activity and piceatannol, a potent antioxidant molecule. These metabolites modify the structure and fluidity of phospholipids within the viral envelope, thereby inhibiting viral entry by impeding membrane fusion. Therefore, with its broad-spectrum antiviral activity, B. subtilis NS12 offers a probiotic-based, environmentally sustainable, and noninvasive antiviral strategy for preventing and controlling respiratory viral infections.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0781"},"PeriodicalIF":11.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12270477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes. 通过应力松弛水凝胶微球减轻软骨细胞内质网应力的细胞冲击吸收。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-17 eCollection Date: 2025-01-01 DOI: 10.34133/research.0777

Ding Zhao, Yihan Li, Lei Xiang, Qimanguli Saiding, Zhiqi Lin, Zhengwei Cai, Juan Wang, Wenguo Cui

{"title":"Cell Shock Absorption via Stress Relaxation Hydrogel Microspheres for Alleviating Endoplasmic Reticulum Stress in Chondrocytes.","authors":"Ding Zhao, Yihan Li, Lei Xiang, Qimanguli Saiding, Zhiqi Lin, Zhengwei Cai, Juan Wang, Wenguo Cui","doi":"10.34133/research.0777","DOIUrl":"10.34133/research.0777","url":null,"abstract":"Chronic mechanical vibrations and endoplasmic reticulum (ER) stress are major contributors to osteoarthritis (OA) progression. This study proposes a novel \"cellular shock absorption\" approach by developing viscoelastic hydrogel microspheres with tunable stress relaxation properties. By modulating the chemical bonds in the hydrogel network through oxidation and hydrazine coupling reaction, hydrogel microspheres capable of absorbing shock and reducing mechanical stimulus-induced ER stress in chondrocytes are created. Cationic liposomes, modified with the cartilage-targeting peptide Wyrgrl and loaded with tauroursodeoxycholic acid (TUDCA), are encapsulated within these hydrogel microspheres. The microspheres not only dissipate intra-articular impact forces, reducing vibration and pressure transmission, but also provide sustained release of TUDCA, alleviating ER stress and slowing OA progression. In vitro studies showed that the stress relaxation time constant (τ) of the microspheres was tuned to 23.81 s, closely resembling the mechanical properties of the cartilage matrix. This property, combined with targeted TUDCA delivery, reduced Grp78 and CHOP expression, alleviating ER stress and inhibiting chondrocyte apoptosis. In vivo, the microspheres preserved joint cartilage structure, suppressed ER stress responses, and substantially delayed OA progression. This strategy presents a promising approach to mitigating cartilage damage and delaying OA by reducing mechanical stress and alleviating ER stress.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0777"},"PeriodicalIF":11.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144660064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables. 太赫兹单极刺激包络对细胞膜通信相关变量影响的研究。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-15 eCollection Date: 2025-01-01 DOI: 10.34133/research.0755

Wenfei Bo, Rong Che, Feng Jia, Kai Sun, Qiang Liu, Lemeng Guo, Xiaobo Zhang, Yubin Gong

{"title":"Study on the Effect of the Envelope of Terahertz Unipolar Stimulation on Cell Membrane Communication-Related Variables.","authors":"Wenfei Bo, Rong Che, Feng Jia, Kai Sun, Qiang Liu, Lemeng Guo, Xiaobo Zhang, Yubin Gong","doi":"10.34133/research.0755","DOIUrl":"10.34133/research.0755","url":null,"abstract":"The development of terahertz science and technology has shown new application prospects in artificial intelligence. Terahertz stimulation can lead to information communication of cells. Terahertz unipolar picosecond pulse train stimulation can activate cell membrane hydrophilic pores and protein ion channels. However, the effect of the envelope of the terahertz unipolar stimulation remains unknown. This paper studies the effect of the envelope on membrane communication-related variables and the accompanying energy consumption by a cell model with considerations of hydrophilic pores and Na+, K+-ATPase. According to the results, terahertz unipolar picosecond pulse train stimulation can deliver the signal contained in its envelope into the variation rates of membrane potentials no matter whether the hydrophilic pores are activated or not and also into the variation rates of the ion flow via the pores after activation of the pores. In contrast, the ion flow via Na+, K+-ATPase seems irrelevant to the signal in the envelope. Moreover, the ion flows show a modulation effect on the variation rates of membrane potentials. The accompanying power dissipations in the cases of different envelopes are similar, as low as around the level of 10-11 W. The results lay the foundations for application in artificial intelligence, like brain-machine communications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0755"},"PeriodicalIF":11.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144643294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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