Research最新文献_第2页

High-Performance Room-Temperature Terahertz Photodetection Using 2-Dimensional Electron Gas Channel Transport. 利用二维电子气通道输运的高性能室温太赫兹光探测。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.34133/research.0656

Mengjuan Liu, Yongzhen Li, Ziyang Ren, Yao Wang, Haiming Zhu, Qinxi Qiu, Nasir Ali, He Zhu, Jiaqi Zhu, Weien Lai, Zhiming Huang, Huizhen Wu

{"title":"High-Performance Room-Temperature Terahertz Photodetection Using 2-Dimensional Electron Gas Channel Transport.","authors":"Mengjuan Liu, Yongzhen Li, Ziyang Ren, Yao Wang, Haiming Zhu, Qinxi Qiu, Nasir Ali, He Zhu, Jiaqi Zhu, Weien Lai, Zhiming Huang, Huizhen Wu","doi":"10.34133/research.0656","DOIUrl":"10.34133/research.0656","url":null,"abstract":"Room-temperature (RT) terahertz (THz) detection finds widespread applications in security inspection, communication, biomedical imaging, and scientific research. However, the state-of-the-art detection strategies are still limited by issues such as low sensitivity, narrow response range, slow response speed, complex fabrication techniques, and difficulties in scaling up to large arrays. Here, we present a high-sensitivity, broadband-response, and high-speed RT THz detection strategy by utilizing a deep subwavelength metal-semiconductor-metal (MSM) structure. The spontaneously formed 2-dimensional electron gas (2DEG) at the CdTe/PbTe interface provides a superior transport channel characterized by high carrier concentration, low scattering, and high mobility. The synergy of the electromagnetic induced well effect formed in the MSM structure, and the efficient and rapid transport capabilities of the 2DEG channel give rise to an impressive performance improvement. The proposed 2DEG photodetector exhibits a broad frequency range from 22 to 519 GHz, an ultralow noise equivalent power of 3.0 × 10-14 W Hz-1/2 at 166 GHz, and a short response time of 6.7 μs. This work provides an effective route for the development of high-performance RT THz detection strategies, paving the way for enhanced THz technology applications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0656"},"PeriodicalIF":11.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143721185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision Microbiome: A New Era of Targeted Therapy with Core Probiotics. 精密微生物组：核心益生菌靶向治疗的新时代。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-26 eCollection Date: 2025-01-01 DOI: 10.34133/research.0658

Xiuyu Fang, Yuhao Wang, Hong Wei, Yuan Huang

引用次数: 0

Dynamic Tumor Immunology-on-a-Chip for Peripheral Blood-Derived Tumor-Reactive T Cell Expansion. 动态肿瘤免疫芯片用于外周血源性肿瘤反应性T细胞扩增。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.34133/research.0639

Xin Shou, Yunru Yu, Dan Wu, Peihua Lu, Miaoqing Zhao, Yuanjin Zhao

{"title":"Dynamic Tumor Immunology-on-a-Chip for Peripheral Blood-Derived Tumor-Reactive T Cell Expansion.","authors":"Xin Shou, Yunru Yu, Dan Wu, Peihua Lu, Miaoqing Zhao, Yuanjin Zhao","doi":"10.34133/research.0639","DOIUrl":"10.34133/research.0639","url":null,"abstract":"Adoptive T cell therapy has shown great promise in the treatment of solid tumors, which, however, poses a great challenge to obtain autologous tumor-reactive T cells in a cost-effective manner. Here, we present a dynamic tumor immunology-on-a-chip, mimicking immune responses, for achieving the enrichment and expansion of tumor-reactive T cells. Tumor spheroids with uniform size can be generated by seeding tumor cells in hydrogel-embedded micropillar arrays, and could be trapped upon removal of hydrogel. Then, T cells were infused and fully contacted with these tumor spheroids under biomimetic flow conditions provided by herringbone-patterned microgrooves arrays. We found that the tamed tumor-reactive T cells could be fully activated and a rapid clonal proliferation was realized during the cultivation. In addition, these tumor-reactive T cells exhibited a specific and powerful tumor-killing capability in vitro. Thus, the suggested dynamic microfluidic chips with staged structure-transformable properties realize both the producible formation of tumor spheroids and the recapitulation of tumor-immune crosstalk to expand tumor-reactive T cells. These features indicate that the dynamic and reproducible tumor immunology-on-a-chip has potential in the preparation of therapeutic T cell products for clinical cancer immunotherapy.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0639"},"PeriodicalIF":11.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Upcycling of Degraded Prussian Blue into Layered Materials for Sodium-Ion Battery. 降解普鲁士蓝升级回收制备钠离子电池层状材料。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-21 eCollection Date: 2025-01-01 DOI: 10.34133/research.0643

Weng-Lam Wong, Jiahui Xu, Yun Zhao, Yadong Wang, Hao Du, Junhao Zhang, Yuqiong Kang, Yuqing Chen, Feiyu Kang, Baohua Li

{"title":"Upcycling of Degraded Prussian Blue into Layered Materials for Sodium-Ion Battery.","authors":"Weng-Lam Wong, Jiahui Xu, Yun Zhao, Yadong Wang, Hao Du, Junhao Zhang, Yuqiong Kang, Yuqing Chen, Feiyu Kang, Baohua Li","doi":"10.34133/research.0643","DOIUrl":"10.34133/research.0643","url":null,"abstract":"Prussian blue and Prussian blue analogs are widely used in sodium-ion batteries (SIBs). In this study, we upcycle the degraded Prussian blue directly into layered materials for SIBs through thermal treatment. Prussian blue thermally decomposes to form metal oxides, which then recrystallize into layered metal oxides with metal-nitrogen bond on their surface under suitable temperature conditions. This transformation method is similar to solid-state synthesis, allowing for the pre-addition of necessary components before material conversion to optimize the composition and integrity of the target materials. Based on in situ x-ray diffraction observations of the crystal structure changes of Prussian blue at different temperatures, we demonstrate 1,000 °C as the optimal temperature for converting to layered materials. These materials exhibit an initial discharge capacity of 122.3 mAh g-1 and good rate and cycling stability. We hope that this research will promote the sustainable development of the SIB industry.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0643"},"PeriodicalIF":11.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Gut Microbiota Contributes to Acute-Respiratory-Distress-Syndrome-Related Depression through Microglial Neuroinflammation. 肠道菌群改变通过小胶质神经炎症导致急性呼吸窘迫综合征相关抑郁

IF 11 1区综合性期刊

Research Pub Date : 2025-03-19 eCollection Date: 2025-01-01 DOI: 10.34133/research.0636

Bowen Zhu, Zheng Gu, Hongbin Hu, Jie Huang, Zhenhua Zeng, Haoxuan Liang, Ziyi Yuan, Shiwei Huang, Yuetan Qiu, Xiang-Dong Sun, Youtan Liu

{"title":"Altered Gut Microbiota Contributes to Acute-Respiratory-Distress-Syndrome-Related Depression through Microglial Neuroinflammation.","authors":"Bowen Zhu, Zheng Gu, Hongbin Hu, Jie Huang, Zhenhua Zeng, Haoxuan Liang, Ziyi Yuan, Shiwei Huang, Yuetan Qiu, Xiang-Dong Sun, Youtan Liu","doi":"10.34133/research.0636","DOIUrl":"10.34133/research.0636","url":null,"abstract":"Acute respiratory distress syndrome (ARDS) survivors often suffer from long-term psychiatric disorders such as depression, but the underlying mechanisms remain unclear. Here, we found marked alterations in the composition of gut microbiota in both ARDS patients and mouse models. We investigated the role of one of the dramatically changed bacteria-Akkermansia muciniphila (AKK), whose abundance was negatively correlated with depression phenotypes in both ARDS patients and ARDS mouse models. Specifically, while fecal transplantation from ARDS patients into naive mice led to depressive-like behaviors, microglial activation, and intestinal barrier destruction, colonization of AKK or oral administration of its metabolite-propionic acid-alleviated these deficits in ARDS mice. Mechanistically, AKK and propionic acid decreased microglial activation and neuronal inflammation through inhibiting the Toll-like receptor 4/nuclear factor κB signaling pathway. Together, these results reveal a microbiota-dependent mechanism for ARDS-related depression and provide insight for developing a novel preventative strategy for ARDS-related psychiatric symptoms.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0636"},"PeriodicalIF":11.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143664394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Notch2 Signaling Drives Cardiac Hypertrophy by Suppressing Purine Nucleotide Metabolism. Notch2信号通过抑制嘌呤核苷酸代谢驱动心肌肥厚。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.34133/research.0635

Yuhong Wang, Yizhe Li, Shihong Chen, Tingting Yu, Weiyan Sun, Jiao Liu, Huiwen Ren, Yao Zhou, Lu Wang, Xixi Tao, Ronglu Du, Wenlong Shang, Yinxiu Li, Danyang Tian, Bei Wang, Yujun Shen, Qian Liu, Ying Yu

{"title":"Notch2 Signaling Drives Cardiac Hypertrophy by Suppressing Purine Nucleotide Metabolism.","authors":"Yuhong Wang, Yizhe Li, Shihong Chen, Tingting Yu, Weiyan Sun, Jiao Liu, Huiwen Ren, Yao Zhou, Lu Wang, Xixi Tao, Ronglu Du, Wenlong Shang, Yinxiu Li, Danyang Tian, Bei Wang, Yujun Shen, Qian Liu, Ying Yu","doi":"10.34133/research.0635","DOIUrl":"10.34133/research.0635","url":null,"abstract":"Gain-of-function mutations of Notch2 cause the rare autosomal dominant disorder known as Hajdu-Cheney syndrome (HCS). Most patients with HCS develop congenital heart disease; however, the precise mechanisms remain elusive. Here, a murine model expressing the human Notch2 intracellular domain (hN2ICD) in cardiomyocytes (hN2ICD-TgCM) was generated and the mice spontaneously developed ventricular diastolic dysfunction with preserved ejection fraction and cardiac hypertrophy. Ectopic hN2ICD expression promoted cardiomyocyte hypertrophy by suppressing adenylosuccinate lyase (ADSL)-mediated adenosine 5'-monophosphate (AMP) generation, which further enhanced the activation of the mammalian target of rapamycin complex 1 pathway by reducing AMP-activated kinase activity. Hairy and enhancer of split 1 silencing abrogated hN2ICD-induced cardiomyocyte hypertrophy by increasing Adsl transcription. Importantly, pharmacological activation of AMP-activated kinase ameliorated cardiac hypertrophy and dysfunction in hN2ICD-TgCM mice. The frameshift mutation in Notch2 exon 34 (c.6426dupT), which causes early-onset HCS, induces AC16 human cardiomyocyte hypertrophy through suppressing ADSL-mediated AMP generation. Thus, targeting Notch2-mediated purine nucleotide metabolism may be an attractive therapeutic approach to heart failure treatment.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0635"},"PeriodicalIF":11.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11913782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Palmitoyl-carnitine Regulates Lung Development by Promoting Pulmonary Mesenchyme Proliferation. 棕榈酰肉碱通过促进肺间质增殖调节肺发育。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-18 eCollection Date: 2025-01-01 DOI: 10.34133/research.0620

Xing Liu, Sin Man Lam, Yu Zheng, Lesong Mo, Muhan Li, Tianyi Sun, Xiaohui Long, Shulin Peng, Xinwei Zhang, Mei Mei, Guanghou Shui, Shilai Bao

{"title":"Palmitoyl-carnitine Regulates Lung Development by Promoting Pulmonary Mesenchyme Proliferation.","authors":"Xing Liu, Sin Man Lam, Yu Zheng, Lesong Mo, Muhan Li, Tianyi Sun, Xiaohui Long, Shulin Peng, Xinwei Zhang, Mei Mei, Guanghou Shui, Shilai Bao","doi":"10.34133/research.0620","DOIUrl":"10.34133/research.0620","url":null,"abstract":"Disruption of acylcarnitine homeostasis results in life-threatening outcomes in humans. Carnitine-acylcarnitine translocase deficiency (CACTD) is a scarce autosomal recessive genetic disease and may result in patients' death due to heart arrest or respiratory insufficiency. However, the reasons and mechanism of CACTD inducing respiratory insufficiency have never been elucidated. Herein, we employed lipidomic techniques to create comprehensive lipidomic maps of entire lungs throughout both prenatal and postnatal developmental stages in mice. We found that the acylcarnitines manifested notable variations and coordinated the expression levels of carnitine-acylcarnitine translocase (Cact) across these lung developmental stages. Cact-null mice were all dead with a symptom of respiratory distress and exhibited failed lung development. Loss of Cact resulted in an accumulation of palmitoyl-carnitine (C16-acylcarnitine) in the lungs and promoted the proliferation of mesenchymal progenitor cells. Mesenchymal cells with elevated C16-acylcarnitine levels displayed minimal changes in energy metabolism but, upon investigation, revealed an interaction with sterile alpha motif domain and histidine-aspartate domain-containing protein 1 (Samhd1), leading to decreased protein abundance and enhanced cell proliferation. Thus, our findings present a mechanism addressing respiratory distress in CACTD, offering a valuable reference point for both the elucidation of pathogenesis and the exploration of treatment strategies for neonatal respiratory distress.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0620"},"PeriodicalIF":11.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioinspired Spatially Ordered Multicellular Lobules for Liver Regeneration. 肝脏再生的生物启发空间有序多细胞小叶。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-17 eCollection Date: 2025-01-01 DOI: 10.34133/research.0634

Jinglin Wang, Danqing Huang, Haozhen Ren, Yuanjin Zhao

{"title":"Bioinspired Spatially Ordered Multicellular Lobules for Liver Regeneration.","authors":"Jinglin Wang, Danqing Huang, Haozhen Ren, Yuanjin Zhao","doi":"10.34133/research.0634","DOIUrl":"10.34133/research.0634","url":null,"abstract":"Cell therapy is a promising strategy for acute liver failure (ALF), while its therapeutic efficacy is often limited by cell loss and poor arrangement. Here, inspired by liver microunits, we propose a novel spatially ordered multicellular lobules for the ALF treatment by using a microfluidic continuous spinning technology. The microfluidics with multiple microchannels was constructed by assembling parallel capillaries. Sodium alginate (Alg) solution encapsulating human umbilical vein endothelial cells (HUVECs), hepatocytes, and mesenchymal stem cells (MSCs) are introduced into the middle channel and the 6 parallel outer channels of the microfluidics, respectively. Simultaneously, Ca2+-loaded solutions are pumped through the innermost and outermost channels, forming a hollow microfiber with hepatocytes and MSCs alternately surrounding the HUVECs. These microfibers could highly resemble the cord-like structure of liver lobules, bringing about outstanding liver-like functions. We have demonstrated that in ALF rats, our biomimetic lobules can effectively suppress excessive inflammatory responses, decrease cell necrosis, and promote regenerative pathways, leading to satisfied therapeutic efficacy. These findings underscore the potential of spatially ordered multicellular microfibers in treating related diseases and improving traditional clinical methods.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0634"},"PeriodicalIF":11.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ViE-Take: A Vision-Driven Multi-Modal Dataset for Exploring the Emotional Landscape in Takeover Safety of Autonomous Driving. ViE-Take：一个视觉驱动的多模态数据集，用于探索自动驾驶接管安全中的情感景观。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0603

Yantong Wang, Yu Gu, Tong Quan, Jiaoyun Yang, Mianxiong Dong, Ning An, Fuji Ren

{"title":"ViE-Take: A Vision-Driven Multi-Modal Dataset for Exploring the Emotional Landscape in Takeover Safety of Autonomous Driving.","authors":"Yantong Wang, Yu Gu, Tong Quan, Jiaoyun Yang, Mianxiong Dong, Ning An, Fuji Ren","doi":"10.34133/research.0603","DOIUrl":"https://doi.org/10.34133/research.0603","url":null,"abstract":"Takeover safety draws increasing attention in the intelligent transportation as the new energy vehicles with cutting-edge autopilot capabilities vigorously blossom on the road. Despite recent studies highlighting the importance of drivers' emotions in takeover safety, the lack of emotion-aware takeover datasets hinders further investigation, thereby constraining potential applications in this field. To this end, we introduce ViE-Take, the first Vision-driven (Vision is used since it constitutes the most cost-effective and user-friendly solution for commercial driver monitor systems) dataset for exploring the Emotional landscape in Takeovers of autonomous driving. ViE-Take enables a comprehensive exploration of the impact of emotions on drivers' takeover performance through 3 key attributes: multi-source emotion elicitation, multi-modal driver data collection, and multi-dimensional emotion annotations. To aid the use of ViE-Take, we provide 4 deep models (corresponding to 4 prevalent learning strategies) for predicting 3 different aspects of drivers' takeover performance (readiness, reaction time, and quality). These models offer benefits for various downstream tasks, such as driver emotion recognition and regulation for automobile manufacturers. Initial analysis and experiments conducted on ViE-Take indicate that (a) emotions have diverse impacts on takeover performance, some of which are counterintuitive; (b) highly expressive social media clips, despite their brevity, prove effective in eliciting emotions (a foundation for emotion regulation); and (c) predicting takeover performance solely through deep learning on vision data not only is feasible but also holds great potential.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0603"},"PeriodicalIF":11.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Carbene-Catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucide that Specifically Targets Viral Nia Protein to Inhibit Proliferation. 碳催化酞醚功能化发现手性植物杀菌剂特异性靶向病毒Nia蛋白抑制增殖。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-14 eCollection Date: 2025-01-01 DOI: 10.34133/research.0637

Xiaoyi Wang, Weijia Yang, Shang Wu, Fangru Jin, Zhongjie Shen, Xiangyang Li, Yonggui Robin Chi, Baoan Song, Runjiang Song

{"title":"Carbene-Catalyzed Phthalide Ether Functionalization for Discovering Chiral Phytovirucide that Specifically Targets Viral Nia Protein to Inhibit Proliferation.","authors":"Xiaoyi Wang, Weijia Yang, Shang Wu, Fangru Jin, Zhongjie Shen, Xiangyang Li, Yonggui Robin Chi, Baoan Song, Runjiang Song","doi":"10.34133/research.0637","DOIUrl":"https://doi.org/10.34133/research.0637","url":null,"abstract":"Plant diseases caused by vegetable viruses are an important threat to global food security, presenting a major challenge for the development of antiviral agrochemicals. Functional proteins of plant viruses play a crucial role in the viral life cycle, and targeted inhibition of these proteins has emerged as a promising strategy. However, the current discovery of antiviral small molecules is hampered by the limitations of synthetic approaches and the narrow range of targets. Herein, we report a practical application of organocatalysis for serving pesticide discovery that bears a unique molecular basis. An N-heterocyclic carbene-modulated reaction is first designed to asymmetrically functionalize diverse natural phenols with phthalides. Our designed method is capable of producing a series of new phthalidyl ethers under mild conditions with good yields, enantioselectivity, and functional group tolerance. Among these, compound (R)-3w exhibits excellent and enantioselectivity-preferred curative activity against potato virus Y (PVY). Mechanistically, it is proposed that (R)-3w interacts with the nuclear inclusion body A (Nia) protein of PVY at the His150 residue. This binding impairs Nia's function to cleavage polyprotein, thereby inhibiting formation of viral replication complex. The study provides insights into advancing synthetic protocol to facilitate agrochemical discovery, and our identified (R)-3w may serve as a potential lead for future research and development PVY-Nia inhibitors.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0637"},"PeriodicalIF":11.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11908822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143650060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0