Research最新文献_第3页

Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1. Daurisoline通过靶向LRP1调节tbk1依赖性I型干扰素途径增强抗肿瘤免疫

IF 11 1区综合性期刊

Research Pub Date : 2025-07-04 eCollection Date: 2025-01-01 DOI: 10.34133/research.0764

Borui Tang, Yuting Wang, Liping Li, Cuicui Sun, Jingwen Dong, Ruoqi Li, Jianfeng Wang, Yu Long, Mingxiao Yin, Fei Xie, Dian Xiao, Xinbo Zhou, Na Zhang, Xiuli Zhao, Yanchun Feng, Hongbin Deng

{"title":"Daurisoline Modulates the TBK1-Dependent Type I Interferon Pathway to Boost Anti-tumor Immunity via Targeting of LRP1.","authors":"Borui Tang, Yuting Wang, Liping Li, Cuicui Sun, Jingwen Dong, Ruoqi Li, Jianfeng Wang, Yu Long, Mingxiao Yin, Fei Xie, Dian Xiao, Xinbo Zhou, Na Zhang, Xiuli Zhao, Yanchun Feng, Hongbin Deng","doi":"10.34133/research.0764","DOIUrl":"10.34133/research.0764","url":null,"abstract":"A promising therapeutic approach in oncology involves immune checkpoint blockade (ICB), which stimulates anti-tumor immune responses. Nevertheless, the effectiveness of this treatment in clinical settings remains limited, underscoring the need for complementary strategies. Recent studies highlight the potential of type I interferon (IFN-I) inducers to reprogram the tumor microenvironment and enhance ICB outcomes. Herein, through high-content screening of a natural compound library, we identified daurisoline (DS), a bioactive alkaloid extracted from the Chinese herbal medicine Rhizoma Menispermi, as a potent inducer of IFN-I signaling. Our findings indicated that DS up-regulates interferon responses and pro-inflammatory cytokine expression in a TANK-binding kinase 1 (TBK1)-dependent manner. In vivo, DS exhibited marked tumor growth inhibition by activating dendritic cells, macrophages, and CD8+ T cells, thereby enhancing anti-tumor immunity. Utilizing the LiP-SMap approach, we identified low-density lipoprotein receptor-related protein 1 (LRP1) as the direct target of DS. Mechanistically, the binding of DS to LRP1 substantially disrupted lysosomal function, which subsequently triggered 5'-azacytidine-induced protein 2-mediated TBK1 activation and IFN-I production. Furthermore, DS demonstrated synergistic effects with anti-programmed death 1 therapy and a stimulator of interferon genes agonist by remodeling the immunosuppressive microenvironment. Collectively, our findings establish LRP1 as a novel therapeutic target for cancer immunotherapy and highlight DS-driven immune reprogramming as a translatable strategy to potentiate ICB efficacy.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0764"},"PeriodicalIF":11.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microbubble-Templated Immunoactive Metal-Phenolic Capsules for Drug Delivery and Enhanced Cancer Immunotherapy. 微泡模板免疫活性金属酚胶囊用于药物传递和增强癌症免疫治疗。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-04 eCollection Date: 2025-01-01 DOI: 10.34133/research.0752

Xin Tan, Xiaojing Wu, Renwang Sheng, Yinghua Tao, Weikun Li, Yanling Liang, Bo Gui, Huiqin Lu, Diyi Feng, Nuoya Chen, Fangzhou Liu, Ling Liu, Liqin Ge

{"title":"Microbubble-Templated Immunoactive Metal-Phenolic Capsules for Drug Delivery and Enhanced Cancer Immunotherapy.","authors":"Xin Tan, Xiaojing Wu, Renwang Sheng, Yinghua Tao, Weikun Li, Yanling Liang, Bo Gui, Huiqin Lu, Diyi Feng, Nuoya Chen, Fangzhou Liu, Ling Liu, Liqin Ge","doi":"10.34133/research.0752","DOIUrl":"10.34133/research.0752","url":null,"abstract":"Advanced drug delivery systems integrating immunomodulatory functions can improve cancer therapy. Herein, we develop a novel metal-phenolic capsule for synergistic drug delivery and immunomodulation. Specifically, a stable metal-phenolic network (MPN), formed by Fe (III), tannic acid, and catechol-modified hyaluronic acid, was assembled onto doxorubicin (DOX)-loaded mannose-glycated bovine serum albumin microbubbles to construct microcapsules with both drug loading and immunomodulatory functions simultaneously. The capsules release DOX in a pH-responsive manner and induce reactive oxygen species accumulation in tumor cells, thereby enhancing immunogenic cell death (ICD). This ICD effect, combined with the direct stimulation of dendritic cells (DCs) by the capsules and the paracrine signaling from capsule-activated M1 macrophages, synergistically promotes DC maturation. In vivo bilateral tumor models demonstrate that DmTFH substantially inhibits primary and distant tumor development and markedly delays metastasis to the lungs. Flow cytometry analysis confirms robust local and systemic immune responses, characterized by enhanced DC maturation within lymph nodes and increased infiltration of activated CD8+ and CD4+ T cells in tumors and spleens. Overall, the immunoactive MPN microcapsules constructed in this study enhance the immunotherapeutic efficacy of DOX through the synergistic action of carrier-inherent immunomodulation and chemotherapy, providing a promising approach for combinatorial cancer therapy.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0752"},"PeriodicalIF":11.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temperature-Responsive Microrobot for High-Temperature Sensing in Constrained Environments. 约束环境中高温传感的温度响应微型机器人。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-04 eCollection Date: 2025-01-01 DOI: 10.34133/research.0760

Shaobo Ding, Junmin Liu, Jiaxu Dong, Rencheng Zhuang, Enbo Shi, Shutong Wang, Yuhang Xiao, Dekai Zhou, Longqiu Li, Xiaocong Chang

{"title":"Temperature-Responsive Microrobot for High-Temperature Sensing in Constrained Environments.","authors":"Shaobo Ding, Junmin Liu, Jiaxu Dong, Rencheng Zhuang, Enbo Shi, Shutong Wang, Yuhang Xiao, Dekai Zhou, Longqiu Li, Xiaocong Chang","doi":"10.34133/research.0760","DOIUrl":"10.34133/research.0760","url":null,"abstract":"Temperature measurement in confined environments has long been a substantial challenge. Due to poor accessibility to constrained space, and low visibility, conventional thermometry and existing nanoscale thermometers struggle to achieve efficient and accurate temperature detection. As an emerging technology, microrobots offer great potential for temperature sensing in such challenging conditions. Here, we propose a temperature-responsive microrobot (TRM) that integrates artificial neural networks into microscale thermal sensing, enabling quantitative temperature measurement in complex and constrained environments. The TRM undergoes irreversible color changes in a high-temperature range of 160 to 240 °C. It features a Janus structure composed of a Cu(NH3)4SO4-based thermochromic material and a nickel-coated magnetic actuation layer, allowing reliable operation in nontransparent and geometrically confined environments such as porous geological structures and constrained microspaces. The thermochromic mechanism and motion dynamics of the TRM under elevated temperatures were systematically investigated. The microrobot exhibits distinct chromatic responses at different temperatures. Based on the correlation between chromaticity and temperature, a multilayer perceptron neural network was developed. By inputting the observed color features into the trained model, the surrounding temperature can be quantitatively determined. Experimental results in a simulated porous microchannel model confirmed the feasibility and effectiveness of the TRM for localized high-temperature detection. This work provides a new solution for temperature sensing in restricted environments and lays a solid foundation for the application of microrobots in industrial high-temperature monitoring, highlighting their potential for real-world deployment in complex conditions.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0760"},"PeriodicalIF":11.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memristor-Based Artificial Neural Networks for Hardware Neuromorphic Computing. 基于忆阻器的人工神经网络硬件神经形态计算。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-04 eCollection Date: 2025-01-01 DOI: 10.34133/research.0758

Boyan Jin, Zhenlong Wang, Tianyu Wang, Jialin Meng

{"title":"Memristor-Based Artificial Neural Networks for Hardware Neuromorphic Computing.","authors":"Boyan Jin, Zhenlong Wang, Tianyu Wang, Jialin Meng","doi":"10.34133/research.0758","DOIUrl":"10.34133/research.0758","url":null,"abstract":"Artificial neural networks have long been studied to emulate the cognitive capabilities of the human brain for artificial intelligence (AI) computing. However, as computational demands intensify, conventional hardware based on transistor and complementary metal oxide semiconductor (CMOS) technology faces substantial limitations due to the separation of memory and processing, a challenge commonly known as the von Neumann bottleneck. In this review, we examine how memristors, which are novel nonvolatile memory devices that exhibit memory-dependent resistance, can be harnessed to build more efficient and scalable neural networks. We provide a comprehensive background on the evolution of neural network models and memristors, as well as introduce the principles of memristive devices, which mimic the dynamic behavior of biological synapses. Various neural network architectures, including convolutional, recurrent, and spiking models, are discussed, highlighting the advantages of integrating memristors for in-memory computing and parallel processing. Our review further examines key mechanisms such as synaptic plasticity, encompassing both long-term potentiation and depression, as well as emerging learning algorithms that leverage memristive behavior. Finally, we identify current challenges, such as achieving ultra-low power consumption, high device uniformity, and seamless system integration, and propose future directions in materials science, device engineering, system integration, and industrialization. These advances suggest that memristor-based neural networks may pave the way for next-generation AI systems that combine low power consumption with high computational performance, ultimately bridging the gap between biological and electronic information processing.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0758"},"PeriodicalIF":11.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12231232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Self-Powered Microsystem for Ultra-Fast Crash Detection via Prestressed Triboelectric Sensing. 基于预应力摩擦电传感的超快速碰撞检测自供电微系统。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.34133/research.0753

Yiqun Wang, Yuhan Wang, Xinzhi Liu, Xiaofeng Wang, Keren Dai, Zheng You

{"title":"Self-Powered Microsystem for Ultra-Fast Crash Detection via Prestressed Triboelectric Sensing.","authors":"Yiqun Wang, Yuhan Wang, Xinzhi Liu, Xiaofeng Wang, Keren Dai, Zheng You","doi":"10.34133/research.0753","DOIUrl":"10.34133/research.0753","url":null,"abstract":"Reliable detection of high-g shocks in extreme impact scenarios, such as automobile collisions, is essential for ensuring occupant safety. Conventional shock sensors based on piezoresistive or capacitive mechanisms often underperform in high-g environments due to their structural complexity, resulting in delayed or missed detection. Here, we present a self-powered high-g shock sensor that combines a triboelectric transducer with a prestressed structure to deliver large signal amplitude and minimal oscillation. The prestress mechanism enhances initial contact strength, achieving a 400% increase in signal amplitude and reduced oscillation. We further developed a self-powered, compact (<4.5 cm3) microsystem that integrates the shock sensor, a signal processing module, airbag triggering circuitry, and a high-g-resistant supercapacitor as a backup power source. The microsystem achieves ultra-fast shock detection and airbag activation with a delay of less than 0.2 ms. Furthermore, its power demand is 80% lower than that of commercial high-g sensors, while the pre-charged supercapacitor ensures operational stability. To further extend the functionality of the device, we designed a lightweight collision target classification algorithm using ensemble learning and feature importance analysis, which could accurately distinguish between automotive collisions with hard, brittle, and soft materials. This study advances triboelectric nanogenerators for high-g shock sensing, offering improved reliability, performance, and real-world adaptability.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0753"},"PeriodicalIF":11.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12218221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools. 利用先进的基因组编辑工具以最小的旁观者编辑精确校正Pde6b-L659P突变导致视网膜变性

IF 11 1区综合性期刊

Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.34133/research.0770

Zhiquan Liu, Siyu Chen, Yang Sun

{"title":"Precise Correction of the Pde6b-L659P Mutation Causing Retinal Degeneration with Minimum Bystander Editing by Advanced Genome Editing Tools.","authors":"Zhiquan Liu, Siyu Chen, Yang Sun","doi":"10.34133/research.0770","DOIUrl":"10.34133/research.0770","url":null,"abstract":"Recently developed base editing (BE), prime editing (PE), and click editing (CE) technologies enable precise and efficient genome editing with minimal risk of double-strand breaks and associated toxicity. However, their effectiveness in correcting real disease-causing mutations has not been systematically compared. Here, we aim to evaluate the potential of BE, PE, and CE technologies in rescuing the retinal degeneration-causing Pde6b (c.1976T>C, p.L659P) mutation. This site is prone to bystander effects, making it an ideal model for comparing the editing outcomes of these 3 novel technologies, particularly their editing precision. We optimized BE, PE, and CE systems in vitro using Pde6b-L659P cell models and compared their editing via deep sequencing. BE and PE had similar efficiency, but PE was the most precise, minimizing bystander edits. CE had lower efficiency and higher indel rates, needing further optimization. Using the optimal PE system for in vivo electroporation in Pde6b-L659P mice, we achieved 12.4% targeted repair with high precision, partially rescuing retinal degeneration. This study demonstrates proof of concept for the precise correction of the Pde6b-L659P mutation causing retinal degeneration using BE, PE, and CE tools. The findings offer valuable insights into the future optimization of precision gene editing techniques and their potential translational applications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0770"},"PeriodicalIF":11.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury. 新生儿启发的小胶质泛程序性细胞死亡重编程促进成人脊髓损伤的再生。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.34133/research.0759

Beibei Yu, Yongfeng Zhang, Yujie Yang, Shijie Yang, Haining Wu, Xue Gao, Yiming Hao, Shengyou Li, Bing Xia, Jintao Liu, Lingli Guo, Borui Xue, Mingze Qin, Huangtao Chen, Jianzhong Li, Shouping Gong, Teng Ma, Jinghui Huang

{"title":"Neonatal-Inspired Reprogramming of Microglial Pan-Programmed Cell Death Enhances Regeneration in Adult Spinal Cord Injury.","authors":"Beibei Yu, Yongfeng Zhang, Yujie Yang, Shijie Yang, Haining Wu, Xue Gao, Yiming Hao, Shengyou Li, Bing Xia, Jintao Liu, Lingli Guo, Borui Xue, Mingze Qin, Huangtao Chen, Jianzhong Li, Shouping Gong, Teng Ma, Jinghui Huang","doi":"10.34133/research.0759","DOIUrl":"10.34133/research.0759","url":null,"abstract":"In adult mammals, programmed cell death (PCD) facilitates tissue remodeling and regeneration in spinal cord injury (SCI), but excessive activation impedes SCI repair. However, no comprehensive pan-PCD atlas exists that encompasses diverse cell death patterns to fully elucidate PCD in adult SCI and develop strategies for modulating the excessive PCD response. Here, we identified neonatal mice with balanced PCD post-SCI as an ideal model for adult SCI. Accordingly, we developed \"Thanatoset\", an SCI-specific gene panel to map tissue and cellular pan-PCD dynamics across neonatal and adult mice. Microglia were identified as pivotal mediators of pan-PCD, showing greater vulnerability in adults than in neonates. According to computational drug screening, withaferin A can revert microglial pan-PCD in adults to a neonatal-like regenerative state. Histological, functional, and molecular analyses corroborated that withaferin A enhances SCI recovery in adults by modulating microglial pan-PCD. These findings highlight the therapeutic potential of the pan-PCD framework for developing strategies to restore regeneration and improve SCI outcomes.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0759"},"PeriodicalIF":11.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12220820/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Powered Insights into Polyclonality and Tumor Evolution. 人工智能驱动的多克隆性和肿瘤进化研究。

IF 11 1区综合性期刊

Research Pub Date : 2025-07-02 eCollection Date: 2025-01-01 DOI: 10.34133/research.0765

Hong Zhao, Trey Ideker, Stephen T C Wong

{"title":"Artificial Intelligence-Powered Insights into Polyclonality and Tumor Evolution.","authors":"Hong Zhao, Trey Ideker, Stephen T C Wong","doi":"10.34133/research.0765","DOIUrl":"10.34133/research.0765","url":null,"abstract":"Recent studies have revealed that polyclonality-where multiple distinct subclones cooperate during early tumor development-is a critical feature of tumor evolution, as demonstrated by Sadien et al. and Lu et al. in Nature (October 2024). These findings show that early polyclonal interactions can overcome fitness barriers, ultimately transitioning to monoclonality as dominant clones emerge. Understanding and targeting these interclonal dynamics offers new therapeutic opportunities. In this perspective, we outline how computational modeling and artificial intelligence (AI) tools can provide deeper insights into tumor polyclonality and identify actionable therapeutic strategies. By applying ligand-receptor interaction analysis, clonal trajectory reconstruction, network and pathway modeling, and spatial analysis, researchers can prioritize communication hubs, evolutionary bottlenecks, and microenvironmental niches that sustain tumor progression. These approaches, when integrated with experimental validation, offer a translational pathway from foundational discoveries to personalized cancer treatments aimed at disrupting cooperative subclonal ecosystems and preventing malignant progression. We commend the recent Nature publications, \"Polyclonality overcomes fitness barriers in Apc-driven tumorigenesis\" by Sadien et al. [1] and \"Polyclonal-to-monoclonal transition in colorectal precancerous evolution\" by Lu et al. [2], both featured on 2024 October 30. These groundbreaking studies employed distinct lineage tracing methods to investigate the origins and evolutionary dynamics of colorectal and intestinal tumorigenesis. Despite their different approaches, both studies reached convergent conclusions: Polyclonality plays a pivotal role in the early stages of tumor development, providing critical insights into how diverse cellular populations collaborate to overcome fitness barriers and drive tumor progression.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0765"},"PeriodicalIF":11.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12217929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144554336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study. 预测2021年至2050年全球外周动脉疾病负担：一项基于人群的研究

IF 11 1区综合性期刊

Research Pub Date : 2025-07-01 eCollection Date: 2025-01-01 DOI: 10.34133/research.0702

Liling Deng, Chenzhen Du, Lu Liu, Yanzhong Wang, Haotian Gu, David G Armstrong, Joseph L Mills, Dirk Hochlenert, Huacong Deng, Junlin Ran, Yan Chen, Xiaoyan Jiang, Yu Ma, Qiu Chen, Wuquan Deng

{"title":"Forecasting the Global Burden of Peripheral Artery Disease from 2021 to 2050: A Population-Based Study.","authors":"Liling Deng, Chenzhen Du, Lu Liu, Yanzhong Wang, Haotian Gu, David G Armstrong, Joseph L Mills, Dirk Hochlenert, Huacong Deng, Junlin Ran, Yan Chen, Xiaoyan Jiang, Yu Ma, Qiu Chen, Wuquan Deng","doi":"10.34133/research.0702","DOIUrl":"10.34133/research.0702","url":null,"abstract":"Vascular disease is the leading cause of death worldwide. Predicting the burden of vascular disease and identifying modifiable key risk factors are critical for developing effective prevention strategies. This study aimed to project the global and regional burden of peripheral artery disease (PAD) from 2021 to 2050, with a specific focus on the impact of modifiable key risk factors and the potential benefits of their management. Compared to the 2021 Global Burden of Disease Study (GBD 2021), the number of PAD cases worldwide is projected to increase by 220% by 2050, reaching a staggering 360 million (95% uncertainty interval, 270 to 450). Age-standardized mortality is expected to double, while disability-adjusted life years (DALYs) are forecasted to rise from 19.7 to 33.1 per 100,000. Among individuals aged ≥65 years, PAD prevalence is projected to surge to 21.7% in women and 14.8% in men. Moreover, over 50% of PAD cases are expected to occur in low- and middle-income countries (LMICs). Metabolic diseases are anticipated to be the primary drivers of the rising PAD burden, with diabetes playing a key role in increasing PAD prevalence and severity. By effectively managing metabolic risk factors, age-standardized prevalence could be reduced by 36%, mortality by 17%, and DALYs by 10%. As metabolic risks, particularly diabetes, continue to rise alongside population aging, the global PAD burden is expected to increase substantially, especially in LMICs. Importantly, proactive metabolic risk management strategies have the potential to markedly alleviate the burden of vascular disease and reduce the growing geographic health disparities.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0702"},"PeriodicalIF":11.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144542034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Constructing Cell-Specific Causal Networks of Individual Cells for Depicting Dynamical Biological Processes. 构建描述动态生物过程的单个细胞的细胞特异性因果网络。

IF 11 1区综合性期刊

Research Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI: 10.34133/research.0743

Xinzhe Huang, Luonan Chen, Xiaoping Liu

{"title":"Constructing Cell-Specific Causal Networks of Individual Cells for Depicting Dynamical Biological Processes.","authors":"Xinzhe Huang, Luonan Chen, Xiaoping Liu","doi":"10.34133/research.0743","DOIUrl":"10.34133/research.0743","url":null,"abstract":"Causal inference is crucial in biological research, as it enables the understanding of complex relationships and dynamic processes that drive cellular behavior, development, and disease. Within this context, gene regulatory network (GRN) inference serves as a key approach for understanding the molecular mechanisms underlying cellular function. Despite substantial advancements, challenges persist in GRN inference, particularly in dynamic rewiring, inferring causality, and context specificity. To tackle these issues, we present single cell-specific causal network (SiCNet), a novel causal network construction method that utilizes single-cell gene expression profiles and a causal inference strategy to construct molecular regulatory networks at a single-cell level. Additionally, SiCNet utilizes cell-specific network information to construct network outdegree matrix (ODM), enhancing the performance of cell clustering. It also enables the construction of context-specific GRNs to identify key regulators of fate transitions for diverse processes such as cellular reprogramming and development. Furthermore, SiCNet can delineate the intricate dynamic regulatory processes involved in development, providing deep insights into the mechanisms governing cellular transitions and the gene regulation across developmental stages.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0743"},"PeriodicalIF":11.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144529451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0