Research最新文献_第3页

Application of Spatial Omics in the Cardiovascular System.

IF 11 1区综合性期刊

Research Pub Date : 2025-03-08 eCollection Date: 2025-01-01 DOI: 10.34133/research.0628

Yuhong Hu, Hao Jia, Hao Cui, Jiangping Song

引用次数: 0

Fat-1 Ameliorates Metabolic Dysfunction-Associated Fatty Liver Disease and Atherosclerosis through Promoting the Nuclear Localization of PPARα in Hamsters.

IF 11 1区综合性期刊

Research Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.34133/research.0577

Wenxi Zhang, Jiabao Guo, Guolin Miao, Jingxuan Chen, Yitong Xu, Pingping Lai, Lianxin Zhang, Yufei Han, Sin Man Lam, Guanghou Shui, Yuhui Wang, Wei Huang, Xunde Xian

{"title":"Fat-1 Ameliorates Metabolic Dysfunction-Associated Fatty Liver Disease and Atherosclerosis through Promoting the Nuclear Localization of PPARα in Hamsters.","authors":"Wenxi Zhang, Jiabao Guo, Guolin Miao, Jingxuan Chen, Yitong Xu, Pingping Lai, Lianxin Zhang, Yufei Han, Sin Man Lam, Guanghou Shui, Yuhui Wang, Wei Huang, Xunde Xian","doi":"10.34133/research.0577","DOIUrl":"10.34133/research.0577","url":null,"abstract":"Fat-1, an enzyme encoded by the fat-1 gene, is responsible for the conversion of endogenous omega-6 polyunsaturated fatty acids into omega-3 polyunsaturated fatty acids in Caenorhabditis elegans. To better investigate whether the expression of Fat-1 will exert a beneficial function in dyslipidemia and metabolic dysfunction-associated fatty liver disease (MAFLD), we established an adeno-associated virus 9 expressing Fat-1. We found that adeno-associated-virus-mediated expression of Fat-1 markedly reduced the levels of plasma triglycerides and total cholesterol but increased high-density lipoprotein levels in male wild-type hamsters on both chow diet and high-fat diet as well as in chow-diet-fed male LDLR-/- hamsters. Fat-1 ameliorated diet-induced MAFLD in wild-type hamsters by enhancing fatty acid oxidation through the hepatic peroxisome proliferator-activated receptor α (PPARα)-dependent pathway. Mechanistically, Fat-1 increased the levels of multiple lipid derivatives as ligands for PPARα and simultaneously facilitated the nuclear localization of PPARα. Our results provide new insights into the multiple therapeutic potentials of Fat-1 to treat dyslipidemia, MAFLD, and atherosclerosis.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0577"},"PeriodicalIF":11.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884683/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis. 视网膜血管形态反映并预测大脑小血管疾病：眼脑成像分析的证据。

IF 11 1区综合性期刊

Research Pub Date : 2025-03-06 eCollection Date: 2025-01-01 DOI: 10.34133/research.0633

Ning Wu, Mingze Xu, Shuohua Chen, Shouling Wu, Jing Li, Ying Hui, Xiaoshuai Li, Zhenchang Wang, Han Lv

{"title":"Retinal Vascular Morphology Reflects and Predicts Cerebral Small Vessel Disease: Evidences from Eye-Brain Imaging Analysis.","authors":"Ning Wu, Mingze Xu, Shuohua Chen, Shouling Wu, Jing Li, Ying Hui, Xiaoshuai Li, Zhenchang Wang, Han Lv","doi":"10.34133/research.0633","DOIUrl":"10.34133/research.0633","url":null,"abstract":"Cerebral small vessel disease (SVD) involves ischemic white matter damage and choroid plexus (CP) dysfunction for cerebrospinal fluid (CSF) production. Given the vascular and CSF links between the eye and brain, this study explored whether retinal vascular morphology can indicate cerebrovascular injury and CP dysfunction in SVD. We assessed SVD burden using imaging phenotypes like white matter hyperintensities (WMH), perivascular spaces, lacunes, and microbleeds. Cerebrovascular injury was quantified by WMH volume and peak width of skeletonized mean diffusivity (PSMD), while CP volume measured its dysfunction. Retinal vascular markers were derived from fundus images, with associations analyzed using generalized linear models and Pearson correlations. Path analysis quantified contributions of cerebrovascular injury and CP volume to retinal changes. Support vector machine models were developed to predict SVD severity using retinal and demographic data. Among 815 participants, 578 underwent ocular imaging. Increased SVD burden markedly correlated with both cerebral and retinal biomarkers, with retinal alterations equally influenced by cerebrovascular damage and CP enlargement. Machine learning models showed robust predictive power for severe SVD burden (AUC was 0.82), PSMD (0.81), WMH volume (0.77), and CP volume (0.80). These findings suggest that retinal imaging could serve as a cost-effective, noninvasive tool for SVD screening based on vascular and CSF connections.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0633"},"PeriodicalIF":11.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11883085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies.

IF 11 1区综合性期刊

Research Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.34133/research.0612

Jie Wang, Fanglin Shao, Qing Xin Yu, Luxia Ye, Dilinaer Wusiman, Ruicheng Wu, Zhouting Tuo, Zhipeng Wang, Dengxiong Li, William C Cho, Wuran Wei, Dechao Feng

{"title":"The Common Hallmarks and Interconnected Pathways of Aging, Circadian Rhythms, and Cancer: Implications for Therapeutic Strategies.","authors":"Jie Wang, Fanglin Shao, Qing Xin Yu, Luxia Ye, Dilinaer Wusiman, Ruicheng Wu, Zhouting Tuo, Zhipeng Wang, Dengxiong Li, William C Cho, Wuran Wei, Dechao Feng","doi":"10.34133/research.0612","DOIUrl":"10.34133/research.0612","url":null,"abstract":"The intricate relationship between cancer, circadian rhythms, and aging is increasingly recognized as a critical factor in understanding the mechanisms underlying tumorigenesis and cancer progression. Aging is a well-established primary risk factor for cancer, while disruptions in circadian rhythms are intricately associated with the tumorigenesis and progression of various tumors. Moreover, aging itself disrupts circadian rhythms, leading to physiological changes that may accelerate cancer development. Despite these connections, the specific interplay between these processes and their collective impact on cancer remains inadequately explored in the literature. In this review, we systematically explore the physiological mechanisms of circadian rhythms and their influence on cancer development. We discuss how core circadian genes impact tumor risk and prognosis, highlighting the shared hallmarks of cancer and aging such as genomic instability, cellular senescence, and chronic inflammation. Furthermore, we examine the interplay between circadian rhythms and aging, focusing on how this crosstalk contributes to tumorigenesis, tumor proliferation, and apoptosis, as well as the impact on cellular metabolism and genomic stability. By elucidating the common pathways linking aging, circadian rhythms, and cancer, this review provides new insights into the pathophysiology of cancer and identifies potential therapeutic strategies. We propose that targeting the circadian regulation of cancer hallmarks could pave the way for novel treatments, including chronotherapy and antiaging interventions, which may offer important benefits in the clinical management of cancer.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0612"},"PeriodicalIF":11.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamically Controlled Flight Altitudes in Robo-Pigeons via Locus Coeruleus Neurostimulation.

IF 11 1区综合性期刊

Research Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.34133/research.0632

Ke Fang, Zhouyi Wang, Yezhong Tang, Xiaofei Guo, Xing Li, Wenbo Wang, Bing Liu, Zhendong Dai

{"title":"Dynamically Controlled Flight Altitudes in Robo-Pigeons via Locus Coeruleus Neurostimulation.","authors":"Ke Fang, Zhouyi Wang, Yezhong Tang, Xiaofei Guo, Xing Li, Wenbo Wang, Bing Liu, Zhendong Dai","doi":"10.34133/research.0632","DOIUrl":"10.34133/research.0632","url":null,"abstract":"Robo-pigeons, a novel class of hybrid robotic systems developed using brain-computer interface technology, hold marked promise for search and rescue missions due to their superior load-bearing capacity and sustained flight performance. However, current research remains largely confined to laboratory environments, and precise control of their flight behavior, especially flight altitude regulation, in a large-scale spatial range outdoors continues to pose a challenge. Herein, we focus on overcoming this limitation by using electrical stimulation of the locus coeruleus (LoC) nucleus to regulate outdoor flight altitude. We investigated the effects of varying stimulation parameters, including stimulation frequency (SF), interstimulus interval (ISI), and stimulation cycles (SC), on the flight altitude of robo-pigeons. The findings indicate that SF functions as a pivotal switch controlling the ascending and descending flight modes of the robo-pigeons. Specifically, 60 Hz stimulation effectively induced an average ascending flight of 12.241 m with an 87.72% success rate, while 80 Hz resulted in an average descending flight of 15.655 m with a 90.52% success rate. SF below 40 Hz did not affect flight altitude change, whereas over 100 Hz caused unstable flights. The number of SC was directly correlated with the magnitude of altitude change, enabling quantitative control of flight behavior. Importantly, electrical stimulation of the LoC nucleus had no significant effects on flight direction. This study is the first to establish that targeted variation of electrical stimulation parameters within the LoC nucleus can achieve precise altitude control in robo-pigeons, providing new insights for advancing the control of flight animal-robot systems in real-world applications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0632"},"PeriodicalIF":11.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Printability in Multi-material Projection-Based 3-Dimensional Bioprinting.

IF 11 1区综合性期刊

Research Pub Date : 2025-03-04 eCollection Date: 2025-01-01 DOI: 10.34133/research.0613

Chao-Fan He, Tian-Hong Qiao, Xu-Chao Ren, Mingjun Xie, Qing Gao, Chao-Qi Xie, Peng Wang, Yuan Sun, Huayong Yang, Yong He

{"title":"Printability in Multi-material Projection-Based 3-Dimensional Bioprinting.","authors":"Chao-Fan He, Tian-Hong Qiao, Xu-Chao Ren, Mingjun Xie, Qing Gao, Chao-Qi Xie, Peng Wang, Yuan Sun, Huayong Yang, Yong He","doi":"10.34133/research.0613","DOIUrl":"10.34133/research.0613","url":null,"abstract":"Accurately reconstructing the intricate structure of natural organisms is the long-standing goal of 3-dimensional (3D) bioprinting. Projection-based 3D printing boasts the highest resolution-to-manufacturing time ratio among all 3D-printing technologies, rendering it a highly promising technique in this field. However, achieving standardized, high-fidelity, and high-resolution printing of composite structures using bioinks with diverse mechanical properties remains a marked challenge. The root of this challenge lies in the long-standing neglect of multi-material printability research. Multi-material printing is far from a simple physical assembly of different materials; rather, effective control of material interfaces is a crucial factor that governs print quality. The current research gap in this area substantively hinders the widespread application and rapid development of multi-material projection-based 3D bioprinting. To bridge this critical gap, we developed a multi-material projection-based 3D bioprinter capable of simultaneous printing with 6 materials. Building upon this, we established a fundamental framework for multi-material printability research, encompassing its core logic and essential process specifications. Furthermore, we clarified several critical issues, including the cross-linking behavior of multicomponent bioinks, mechanical mismatch and interface strength in soft-hard composite structures, the penetration behavior of viscous bioinks within hydrogel polymer networks, liquid entrapment and adsorption phenomena in porous heterogeneous structures, and error source analysis along with resolution evaluation in multi-material printing. This study offers a solid theoretical foundation and guidance for the quantitative assessment of multi-material projection-based 3D bioprinting, holding promise to advance the field toward higher precision and the reconstruction of more intricate biological structures.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0613"},"PeriodicalIF":11.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Elastic Micro-Nano Materials for Diagnosis and Treatment of Thrombosis.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-28 eCollection Date: 2025-01-01 DOI: 10.34133/research.0614

Chenxin Lu, Chunjian Li, Ning Gu, Fang Yang

{"title":"Emerging Elastic Micro-Nano Materials for Diagnosis and Treatment of Thrombosis.","authors":"Chenxin Lu, Chunjian Li, Ning Gu, Fang Yang","doi":"10.34133/research.0614","DOIUrl":"https://doi.org/10.34133/research.0614","url":null,"abstract":"Thrombus is a blood clot that forms in a blood vessel at the point of flaking. Thrombosis is closely associated with cardiovascular diseases caused by different sources and factors. However, the current clinical methods of thrombus diagnosis and treatment still have problems with targeting, permeability, stability, and biosafety. Therefore, in recent years, based on the development of micro/nano technology, researchers have tried to develop some new strategies for the diagnosis and treatment of thrombosis. Due to the unique structural characteristics, the micro-nano materials in physiological environments show excellent transport and delivery properties such as better in vivo circulation, longer life span, better targeting ability, and controllable cellular internalization. Especially, elasticity and stiffness are inherent mechanical properties of some well-designed micro-nano materials, which can make them better adapted to the needs of thrombosis diagnosis and treatment. Herein, this review first introduces the thrombotic microenvironment to characterize the thrombus development process. Then, to fine-tune the pathological occurrence and development of thrombosis, the role of elastic micro-nano materials for thrombus diagnosis and treatment is summarized. The properties, preparation methods, and biological fate of these materials have been discussed in detail. Following, the applications of elastic micro-nano materials in biomedical imaging, drug delivery, and therapy of thrombosis are highlighted. Last, the shortcomings and future design strategies of elastic micro-nano materials in diagnosis and treatment of clinical thrombosis are discussed. This review will provide new ideas for the use of nanotechnology in clinical diagnosis and treatment of thrombus in the future.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0614"},"PeriodicalIF":11.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143543257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Millennium-Scale Atlantic Multidecadal Oscillation and Soil Moisture Influence on Western Mediterranean Cloudiness.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.34133/research.0606

Nazzareno Diodato, Kristina Seftigen, Gianni Bellocchi

{"title":"Millennium-Scale Atlantic Multidecadal Oscillation and Soil Moisture Influence on Western Mediterranean Cloudiness.","authors":"Nazzareno Diodato, Kristina Seftigen, Gianni Bellocchi","doi":"10.34133/research.0606","DOIUrl":"10.34133/research.0606","url":null,"abstract":"Understanding long-term historical changes in cloudiness is essential for elucidating Earth's climate dynamics and variability and its extremes. In this study, we present the first millennial-length reconstruction of the annual total cloud cover (TCC) in the western Mediterranean, covering the period from 969 to 2022 CE. Based on a comprehensive set of hydrological and atmospheric variables, our reconstruction reveals a nuanced pattern of cloudiness evolution over the past millennium. We observe an initial increase in cloudiness until 1600 CE, followed by a substantial decrease in TCC. This shift was driven by a confluence of factors, including the eruption of Mount Tambora in Indonesia in 1815, increased solar forcing, and a positive phase of the Atlantic Multidecadal Oscillation. These complex dynamics have brought modern warming cloud patterns closer to those observed during the medieval period before c. 1250, exceeding the background variability of the Little Ice Age (c. 1250 to 1849). In particular, recent decades have witnessed an unprecedented coupling of intense solar activity, high temperatures, and the lowest cloud cover on record. Our results highlight the importance of inter-oceanic-scale relationships between Atlantic forcing mechanisms and the TCC in shaping future trends in western Mediterranean cloudiness. This study provides valuable insights into the long-term dynamics of cloudiness and its implications for regional climate trends in the western Mediterranean and beyond.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0606"},"PeriodicalIF":11.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gecko-Inspired Intelligent Adhesive Structures for Rough Surfaces.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.34133/research.0630

Yawen Shao, Miao Li, Hongmiao Tian, Fabo Zhao, Jian Xu, Hongrong Hou, Zhijun Zhang, Duorui Wang, Xiaoliang Chen, Wenjun Li, Hongjian Yan, Jinyou Shao

{"title":"Gecko-Inspired Intelligent Adhesive Structures for Rough Surfaces.","authors":"Yawen Shao, Miao Li, Hongmiao Tian, Fabo Zhao, Jian Xu, Hongrong Hou, Zhijun Zhang, Duorui Wang, Xiaoliang Chen, Wenjun Li, Hongjian Yan, Jinyou Shao","doi":"10.34133/research.0630","DOIUrl":"10.34133/research.0630","url":null,"abstract":"Biomimetic dry adhesive structures, inspired by geckos' climbing abilities, have attracted research attention in recent years. However, achieving superior adhesion on a rough surface remains an important challenge, which limits practical applications. Conventional bionic adhesion methods perform well on smooth surfaces, but adhesion strength drastically decreases on rough surfaces due to the reduced contact area. Generally, various adhesive structures have been proposed to increase the contact area without assessing adhesion states, against obtaining good performance on rough surfaces. If an intelligent adhesive approach could be introduced on rough surfaces, it would be beneficial for promoting the development of gecko-inspired adhesives. However, existing adhesive structures with the sensing function usually utilize the adhesive function to support the sensing function, i.e., a sensor with an adhesive function; for other few structures, the sensing function supports adhesion, but they do not focus on improving adhesion performance on rough surfaces. Inspired by the synergistic effect of a kinematic system during the crawling process of geckos, this study proposes an intelligent adhesive structure for rough surfaces. The proposed structure combines a hierarchical bionic dry adhesive structure based on gecko paw microhairs with a flexible capacitive sensor unit. Experimental observations and analytical modeling demonstrate that incorporating mushroom-shaped bionic dry adhesive structures with inclined support micropillars can reduce interface contact stiffness, notably enhancing adhesion on rough surfaces while allowing real-time monitoring of contact states. Moreover, this innovative smart adhesive structure facilitates morphology sensing of contact interfaces, presenting potential advancements in bionic adhesion for morphology sensing applications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0630"},"PeriodicalIF":11.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ-0001283 Aggravates Cardiac Hypertrophy by Targeting Myosin Light Chain 3 Protein.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.34133/research.0626

Wenjing Wang, Lili Chen, Yiheng Zhao, Shuchen Zhang, Xiang Zhou

引用次数: 0