Research最新文献_第4页

Elevated Dickkopf 3 Promotes Abdominal Aortic Aneurysm Formation via Modulated Phenotype Switch of Vascular Smooth Muscle Cells. dickkopf3升高通过调节血管平滑肌细胞表型开关促进腹主动脉瘤形成。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.34133/research.0873

Xuejie Cao, Jinmeng Jia, Qiuyue Gao, Jiaping Tao, Ming Wei, Yanting Song, Hong Wu, Shiyu Jiao, Xinxin Zhu, Xuegong Zhang, Yi Fu, Yuan Wang, Jie Du, Qingbo Xu, Aijuan Qu, Baoqi Yu

{"title":"Elevated Dickkopf 3 Promotes Abdominal Aortic Aneurysm Formation via Modulated Phenotype Switch of Vascular Smooth Muscle Cells.","authors":"Xuejie Cao, Jinmeng Jia, Qiuyue Gao, Jiaping Tao, Ming Wei, Yanting Song, Hong Wu, Shiyu Jiao, Xinxin Zhu, Xuegong Zhang, Yi Fu, Yuan Wang, Jie Du, Qingbo Xu, Aijuan Qu, Baoqi Yu","doi":"10.34133/research.0873","DOIUrl":"10.34133/research.0873","url":null,"abstract":"Abdominal aortic aneurysm (AAA) is a potentially fatal vascular disease with no effective therapeutic intervention. Vascular smooth muscle cell (VSMC) phenotypic switching and elevated matrix metalloproteinase (MMP) levels are key pathogeneses of AAA, although the underlying regulatory mechanisms remain to be fully elucidated. In our study, single-cell RNA-sequencing data analysis demonstrated a substantial elevation in modulated VSMCs in patients with aortic aneurysm, accompanied by Dickkopf 3 (DKK3) up-regulation. Both systemic DKK3 knockout and VSMC-specific DKK3 knockdown led to a marked decrease in both the incidence and mortality of AAA in mice. Reintroduction of DKK3 in Dkk3 -/- Apoe -/- mice via adeno-associated virus (AAV) exacerbated AAA development. DKK3 deficiency maintained the contractile phenotype of VSMC and inhibited MMP production. Given the critical role of TGF-β signaling in VSMC phenotypic switching and the progression of AAA, its regulatory mechanisms exhibit spatiotemporal heterogeneity, and the precise underlying mechanisms require further investigation. Next, we aim to investigate the regulators of this pathway. Mechanistically, DKK3 deficiency activates the TGFβ3-Smad2/3 signaling pathway by down-regulating ATF6, thereby inhibiting VSMC phenotype switching. In summary, these findings indicate that DKK3 drives the phenotypic transition of VSMCs to a synthetic phenotype through the ATF6-TGFβ3-Smad2/3 signaling pathway during the development of AAA, which represents a potential target for therapeutic intervention to maintain VSMC homeostasis in AAA.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0873"},"PeriodicalIF":10.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Therapeutic Platform Combining Transcranial Low-Intensity Ultrasound Stimulation and Curcumin Load Liposome Ameliorates Cerebral Ischemia by Modulating Microglia Polarization-Mediated Neuroinflammatory Microenvironment. 经颅低强度超声刺激和姜黄素负载脂质体联合治疗平台通过调节小胶质细胞极化介导的神经炎症微环境改善脑缺血。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI: 10.34133/research.0861

Haocheng Qin, Di Chen, Bao Zhou, Pengkun Yang, Ya Zheng, Lu Sun, Zhengran Ding, Zhong He, Shuai Zhang, Zijian Hua, Gang Chen, Zhiwen Luo, Yulian Zhu, Yi Wu

{"title":"Synergistic Therapeutic Platform Combining Transcranial Low-Intensity Ultrasound Stimulation and Curcumin Load Liposome Ameliorates Cerebral Ischemia by Modulating Microglia Polarization-Mediated Neuroinflammatory Microenvironment.","authors":"Haocheng Qin, Di Chen, Bao Zhou, Pengkun Yang, Ya Zheng, Lu Sun, Zhengran Ding, Zhong He, Shuai Zhang, Zijian Hua, Gang Chen, Zhiwen Luo, Yulian Zhu, Yi Wu","doi":"10.34133/research.0861","DOIUrl":"10.34133/research.0861","url":null,"abstract":"Successful restoration of blood supply still follows with serious secondary brain injury in cerebral ischemia reperfusion injury (CIRI). However, conventional management after CIRI exhibits numerous limitations.Transcranial low-intensity ultrasound stimulation (TLUS) has been extensively utilized in the field of neuromodulation owing to its characteristics of zero potential side effects, noninvasiveness, deep tissue penetration, and precise spatial targeting capability. Here, we develop a smart multifunctional ultrasound-responsive delivery system to regulate CIRI. Briefly, curcumin, a well-documented safe neuroprotective monomer derived from traditional Chinese medicine, is encapsulated into self-assembled liposomal nanocarriers (RRP@Lipo-Cur). These nanocarriers are modified with reactive oxygen species- and ultrasound-responsive functional elements, as well as neuron-targeting peptides, enabling targeted accumulation in ischemic penumbra and stimuli-responsive drug release. In the mouse model of middle cerebral artery occlusion/reperfusion (MCAO/r), the synergistic treatment of RRP@Lipo-Cur and TLUS significantly facilitated the polarization of microglia from the M1 to the M2 phenotype via the intracellular mitogen-activated protein kinase (MAPK) and nuclear factor κB signaling (NF-κB) pathways, which effectively promoted the establishment of an anti-inflammatory microenvironment in the ischemic penumbra, thereby providing neuroprotection for the damaged neurons. Furthermore, in comparison to single nanomaterial or TLUS interventions, synergistic treatment can optimally modulate neuroinflammation, safeguard injured neurons, and enhance the recovery of neurological function.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0861"},"PeriodicalIF":10.7,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145065017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BatGPT-Chem: A Foundation Large Model for Chemical Engineering. BatGPT-Chem：化学工程的基础大型模型。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-10 eCollection Date: 2025-01-01 DOI: 10.34133/research.0827

Yifei Yang, Runhan Shi, Zuchao Li, Shu Jiang, Bao-Liang Lu, Qibin Zhao, Yang Yang, Hai Zhao

{"title":"BatGPT-Chem: A Foundation Large Model for Chemical Engineering.","authors":"Yifei Yang, Runhan Shi, Zuchao Li, Shu Jiang, Bao-Liang Lu, Qibin Zhao, Yang Yang, Hai Zhao","doi":"10.34133/research.0827","DOIUrl":"10.34133/research.0827","url":null,"abstract":"Large language models (LLMs) have showcased remarkable capabilities in the realm of AI for Science, and chemistry has greatly benefited from the advancement of AI tools. With a strong capacity for learning sequential data like natural language, LLMs offer immense potential. Despite this promise, the application of LLMs in chemistry remains limited, with few models specifically designed for chemical data and tasks. Hence, we propose leveraging LLMs to comprehensively model both chemical sequences and natural language sequences, aiming to tackle diverse chemical tasks. We introduce BatGPT-Chem, a general foundation large-scale model with 15 billion parameters tailored for chemical engineering. Built on a corpus of over 100 million chemical instances, BatGPT-Chem specializes in 5 core tasks: retrosynthesis prediction, molecule design, molecule description, product inference, and yield prediction. BatGPT-Chem comprehensively models the information flow between chemical language and natural language, enabling full-spectrum prediction across chemical tasks. It is one of the largest bilingual chemistry-specific LLMs, supporting both English and Chinese for input and output. BatGPT-Chem is also the first automated retrosynthesis tool capable of explicitly predicting reaction conditions, a critical but often overlooked aspect in previous models. Through rigorous zero-shot evaluations, BatGPT-Chem demonstrates state-of-the-art performance, surpassing both existing chemical LLMs and general-purpose models in accuracy and validity across a diverse range of tasks. Notably, it demonstrates superior ability in predicting both reactants and reaction conditions, as well as strong generalization in low-data settings. These results suggest that BatGPT-Chem is among the most advanced and practical chemical LLMs, with strong potential to support real-world applications in synthesis planning, drug discovery, and materials design.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0827"},"PeriodicalIF":10.7,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12421729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triaptosis and Cancer: Next Hope? Triaptosis和癌症：下一个希望？

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.34133/research.0880

Zi-Zhan Li, Kan Zhou, Jinmei Wu, Lei-Ming Cao, Guang-Rui Wang, Han-Yue Luo, Bing Liu, Lin-Lin Bu

{"title":"Triaptosis and Cancer: Next Hope?","authors":"Zi-Zhan Li, Kan Zhou, Jinmei Wu, Lei-Ming Cao, Guang-Rui Wang, Han-Yue Luo, Bing Liu, Lin-Lin Bu","doi":"10.34133/research.0880","DOIUrl":"10.34133/research.0880","url":null,"abstract":"Cancer persists as one of the most formidable global public health crises and socioeconomic burdens of our era, compelling the scientific community to develop innovative and diversified therapeutic modalities to revolutionize clinical management and enhance patient outcomes. The recent seminal discovery by Swamynathan et al. has unveiled menadione, a vitamin K precursor, as a potent inducer of triaptosis-a novel regulated cell death pathway mediated through the oxidative modulation of phosphatidylinositol 3-kinase PIK3C3/VPS34. This mechanistically distinct cell death paradigm, characterized by its intimate association with endosomal dysfunction and oxidative stress-induced cellular catastrophe, has demonstrated remarkable therapeutic efficacy in preclinical prostate cancer models, outperforming conventional therapeutic regimens and emerging as a potential paradigm-shifting strategy in oncology. This comprehensive review provides a critical synthesis of the triaptosis discovery landscape, elucidating its molecular intricacies and pathophysiological implications. We systematically examine the multifaceted roles of endosomal biology in oncogenesis and tumor progression, while offering a nuanced perspective on redox homeostasis in malignant cells and the therapeutic potential of oxidative stress modulation. Furthermore, we address the inherent dichotomy of oxidative stress induction in cancer therapy, balancing its therapeutic promise against potential adverse effects. Looking toward the horizon of cancer research, we explore transformative therapeutic strategies leveraging triaptosis induction and its potential applications beyond oncology, aiming to catalyze a new era of precision medicine that ultimately enhances patient survival and quality of life.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0880"},"PeriodicalIF":10.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond Vision Restoration: Broadband Retinal Nanoprosthetics with Tellurium Nanowire Networks. 超越视力恢复：宽带视网膜纳米修复与碲纳米线网络。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.34133/research.0857

Siqi Zhang, Zheng Rong, Liang Chu

引用次数: 0

Fiber Memristor-Based Physical Reservoir Computing for Multimodal Sleep Monitoring. 基于光纤忆阻器的多模态睡眠监测物理库计算。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.34133/research.0870

Jinhao Zhang, Zhenqian Zhu, Jialin Meng, Tianyu Wang

{"title":"Fiber Memristor-Based Physical Reservoir Computing for Multimodal Sleep Monitoring.","authors":"Jinhao Zhang, Zhenqian Zhu, Jialin Meng, Tianyu Wang","doi":"10.34133/research.0870","DOIUrl":"10.34133/research.0870","url":null,"abstract":"Real-time wearable sleep monitors process diverse biological signals while operating under tight energy and computation budgets. The existing algorithms are facing problems of high energy consumption due to separate hardware storage and computation units. In this work, textile-integrated in-memory neuromorphic computing electronics based on MoS2 quantum dot fiber memristors was proposed for physical reservoir computing for the first time. Textile electronics convert raw electroencephalogram (EEG)and snoring audio directly into rich, high-dimensional state vectors based on intrinsic nonlinear dynamics. Leveraging 16 pulse-programmable conductance levels, the reservoir realizes an accuracy of 94.8%, 95.4%, and 93.5% in snoring events, sleep stages, and multimodal fusion, respectively. To enhance the robustness of feature extraction and improve classification performance under noisy conditions, the linear readout layer was replaced with a lightweight convolutional neural network. The hybrid neural network is 6 times faster than traditional deep-learning methods in 24-h segment EEG analysis. The memristors switch at ±1 V and sub-nanoampere currents, providing picowatt energy consumption suited to continuous on-body use. The results establish fiber memristor reservoir computing as an energy-efficient path to in-fabric, multimodal intelligence for next-generation home sleep analysis and wearable health care.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0870"},"PeriodicalIF":10.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417633/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zn₂SnO₄-Based Optoelectronic Synaptic Device for Visual Perception and Applications. 基于zn2sno4的视觉感知光电突触器件及其应用。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.34133/research.0884

Shan Xu, Zhiyuan Guan, Wenqi Yang, Zhenyu Zhou, Zixuan Zhang, Lulu Wang, Xiaoxu Li, Yuchen Li, Xiaobing Yan

{"title":"Zn2SnO4-Based Optoelectronic Synaptic Device for Visual Perception and Applications.","authors":"Shan Xu, Zhiyuan Guan, Wenqi Yang, Zhenyu Zhou, Zixuan Zhang, Lulu Wang, Xiaoxu Li, Yuchen Li, Xiaobing Yan","doi":"10.34133/research.0884","DOIUrl":"10.34133/research.0884","url":null,"abstract":"Visual bionic systems are of crucial importance in the development of artificial intelligence for environmental perception. However, the traditional artificial vision system has problems such as complex system and high energy consumption due to the physical separation of image perception, storage, and processing unit. In this work, we designed an ITO/ZTO/ZnO/ITO/Mica structure optoelectronic synaptic device, which is capable of integrating optical sensing, information storage, and logic computation. Utilizing its excellent light response characteristics, the PPF, learning-experience behavior, and Pavlov experiment were successfully simulated. In a 3 × 5 array, the \"F\" hidden in \"E\" was identified by using 2 different lighting conditions, successfully simulating color recognition. Furthermore, a further design of an automatic meeting vehicle system based on the embedded platform was carried out, and the meeting vehicle behavior was successfully achieved by utilizing the light response of the ZTO device. This discovery demonstrates the potential of ZTO devices in simulating the behavior of biological synapses, providing new avenue for neuroscience research and the development of bioelectronic devices.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0884"},"PeriodicalIF":10.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Positron Beam Loading and Acceleration in the Blowout Regime of a Plasma Wakefield Accelerator. 等离子体韦克菲尔德加速器井喷状态下的正电子束流加载和加速。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-09 eCollection Date: 2025-01-01 DOI: 10.34133/research.0878

Shiyu Zhou, Siqin Ding, Weiming An, Qianqian Su, Jianfei Hua, Fei Li, Warren B Mori, Chan Joshi, Wei Lu

{"title":"Positron Beam Loading and Acceleration in the Blowout Regime of a Plasma Wakefield Accelerator.","authors":"Shiyu Zhou, Siqin Ding, Weiming An, Qianqian Su, Jianfei Hua, Fei Li, Warren B Mori, Chan Joshi, Wei Lu","doi":"10.34133/research.0878","DOIUrl":"10.34133/research.0878","url":null,"abstract":"Plasma wakefield acceleration in the nonlinear blowout regime has achieved marked milestones in electron beam acceleration, demonstrating high acceleration gradients and energy efficiency while preserving excellent beam quality. However, this regime is deemed unsuitable for achieving positron acceleration of comparable results, which is vital for future compact electron-positron colliders. In this article, we find that an intense positron beam loaded at the back of beam-driven blowout cavity can self-consistently induce the focusing field and flatten the longitudinal wakefield, leading to stable, high-efficiency, and high-quality positron acceleration. This is achieved through the formation of an on-axis electron filament induced by positron beam load, which shapes the plasma wakefield in a distinct way compared to electron beam load in the blowout regime. Via a nonlinear analytic model and numerical simulations, we explain the novel beam loading effects of the interaction between the on-axis filament and the blowout cavity. High-fidelity simulations show that a high-charge positron beam can be accelerated with >20% energy transfer efficiency, ~1% energy spread, and ~1 mm·mrad normalized emittance, while considerably depleting the energy of the drive beam. The concept can also be extended to simultaneous acceleration of electron and positron beams and high transformer ratio positron acceleration as well. This development offers a new route for the application of plasma wakefield acceleration into particle physics.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0878"},"PeriodicalIF":10.7,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Metal-Organic Frameworks for Electromagnetic Wave Absorption. 金属-有机电磁波吸收框架研究进展。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.34133/research.0876

Xue Zhang, Gongming Xin, Na Wu, Fei Pan, Jiurong Liu, Zhihui Zeng

{"title":"Recent Advances in Metal-Organic Frameworks for Electromagnetic Wave Absorption.","authors":"Xue Zhang, Gongming Xin, Na Wu, Fei Pan, Jiurong Liu, Zhihui Zeng","doi":"10.34133/research.0876","DOIUrl":"10.34133/research.0876","url":null,"abstract":"With the rapid advancement of communication technologies, issues of electromagnetic pollution and electromagnetic compatibility have become increasingly severe, heightening the demand for high-performance electromagnetic wave absorption materials. Metal-organic frameworks (MOFs) have flourished in this field owing to their chemical tunability, high porosity, tailored topological structures, and functionality. MOF-derived composites exhibit diverse loss mechanisms and heterogeneous structures, achieving lightweight, broadband, and highly efficient absorption. Notably, recent developments in conductive MOFs (cMOFs) have positioned pristine MOFs as promising intrinsic absorbers. Accordingly, this review comprehensively classifies and summarizes recent progresses in MOF derivatives and cMOF-based absorbers, with a focus on 3 critical aspects: design strategies (compositional and structural engineering), absorption performance (reflection loss and bandwidth), and loss mechanisms (dielectric and magnetic loss). Finally, perspectives on future development directions for MOF-based absorption materials are proposed. This review provides methodological guidelines for constructing high-performance MOF-based absorption materials in the future, while highlighting persisting challenges in their development. Ultimately, it charts a course toward designing and fabricating lightweight, broadband, and high-efficiency MOF absorption materials with structural-functional integration.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0876"},"PeriodicalIF":10.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and Prospects. 衰老和年龄相关疾病的免疫疗法：进展、缺陷和前景。

IF 10.7 1区综合性期刊

Research Pub Date : 2025-09-08 eCollection Date: 2025-01-01 DOI: 10.34133/research.0866

Muyang Yang, Shipeng Wu, Jiasi Zhang, Lisen Lu, Deqiang Deng, Qianfeng Xia, Jonathan F Lovell, Xiujuan Shi, Honglin Jin

{"title":"Immunotherapies for Aging and Age-Related Diseases: Advances, Pitfalls, and Prospects.","authors":"Muyang Yang, Shipeng Wu, Jiasi Zhang, Lisen Lu, Deqiang Deng, Qianfeng Xia, Jonathan F Lovell, Xiujuan Shi, Honglin Jin","doi":"10.34133/research.0866","DOIUrl":"10.34133/research.0866","url":null,"abstract":"Aging is characterized by a gradual decline in the functionality of all the organs and tissues, leading to various diseases. As the global population ages, the urgency to develop effective anti-aging strategies becomes increasingly critical due to the growing severity of associated health problems. Immunotherapy offers novel and promising approaches to combat aging by utilizing approaches including vaccines, antibodies, and cytokines to target specific aging-related molecules and pathways. In this review, we summarize the recent advancements of immunotherapies to eliminate senescence cells and senescence-associated secretory phenotypes (SASPs). Next, we describe immunotherapies against age-related diseases containing neurodegenerative diseases, vascular pathologies, type 2 diabetes (T2D), arthritis, osteoporosis, chronic obstructive pulmonary disease (COPD), fibrosis, skin aging, and cancer, detailing the targets, corresponding manipulations, and clinical trials. Related problems including immunosenescence, serious adverse effects, the duality of function of senescent cells and SASPs, and inherent problems of immunotherapy are also discussed, suggesting directions for improvement. In addition to recent development and challenges in the field, we describe a blueprint of personalized aging immunotherapy by multi-omics, Big Data, artificial intelligence (AI), and nanobots in the future, aiming to inspire the development of novel strategies for healthy aging.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0866"},"PeriodicalIF":10.7,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12415338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145030536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0