Research最新文献_第4页

Millennium-Scale Atlantic Multidecadal Oscillation and Soil Moisture Influence on Western Mediterranean Cloudiness.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-26 eCollection Date: 2025-01-01 DOI: 10.34133/research.0606

Nazzareno Diodato, Kristina Seftigen, Gianni Bellocchi

{"title":"Millennium-Scale Atlantic Multidecadal Oscillation and Soil Moisture Influence on Western Mediterranean Cloudiness.","authors":"Nazzareno Diodato, Kristina Seftigen, Gianni Bellocchi","doi":"10.34133/research.0606","DOIUrl":"10.34133/research.0606","url":null,"abstract":"Understanding long-term historical changes in cloudiness is essential for elucidating Earth's climate dynamics and variability and its extremes. In this study, we present the first millennial-length reconstruction of the annual total cloud cover (TCC) in the western Mediterranean, covering the period from 969 to 2022 CE. Based on a comprehensive set of hydrological and atmospheric variables, our reconstruction reveals a nuanced pattern of cloudiness evolution over the past millennium. We observe an initial increase in cloudiness until 1600 CE, followed by a substantial decrease in TCC. This shift was driven by a confluence of factors, including the eruption of Mount Tambora in Indonesia in 1815, increased solar forcing, and a positive phase of the Atlantic Multidecadal Oscillation. These complex dynamics have brought modern warming cloud patterns closer to those observed during the medieval period before c. 1250, exceeding the background variability of the Little Ice Age (c. 1250 to 1849). In particular, recent decades have witnessed an unprecedented coupling of intense solar activity, high temperatures, and the lowest cloud cover on record. Our results highlight the importance of inter-oceanic-scale relationships between Atlantic forcing mechanisms and the TCC in shaping future trends in western Mediterranean cloudiness. This study provides valuable insights into the long-term dynamics of cloudiness and its implications for regional climate trends in the western Mediterranean and beyond.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0606"},"PeriodicalIF":11.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11862910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143516565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gecko-Inspired Intelligent Adhesive Structures for Rough Surfaces.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.34133/research.0630

Yawen Shao, Miao Li, Hongmiao Tian, Fabo Zhao, Jian Xu, Hongrong Hou, Zhijun Zhang, Duorui Wang, Xiaoliang Chen, Wenjun Li, Hongjian Yan, Jinyou Shao

{"title":"Gecko-Inspired Intelligent Adhesive Structures for Rough Surfaces.","authors":"Yawen Shao, Miao Li, Hongmiao Tian, Fabo Zhao, Jian Xu, Hongrong Hou, Zhijun Zhang, Duorui Wang, Xiaoliang Chen, Wenjun Li, Hongjian Yan, Jinyou Shao","doi":"10.34133/research.0630","DOIUrl":"10.34133/research.0630","url":null,"abstract":"Biomimetic dry adhesive structures, inspired by geckos' climbing abilities, have attracted research attention in recent years. However, achieving superior adhesion on a rough surface remains an important challenge, which limits practical applications. Conventional bionic adhesion methods perform well on smooth surfaces, but adhesion strength drastically decreases on rough surfaces due to the reduced contact area. Generally, various adhesive structures have been proposed to increase the contact area without assessing adhesion states, against obtaining good performance on rough surfaces. If an intelligent adhesive approach could be introduced on rough surfaces, it would be beneficial for promoting the development of gecko-inspired adhesives. However, existing adhesive structures with the sensing function usually utilize the adhesive function to support the sensing function, i.e., a sensor with an adhesive function; for other few structures, the sensing function supports adhesion, but they do not focus on improving adhesion performance on rough surfaces. Inspired by the synergistic effect of a kinematic system during the crawling process of geckos, this study proposes an intelligent adhesive structure for rough surfaces. The proposed structure combines a hierarchical bionic dry adhesive structure based on gecko paw microhairs with a flexible capacitive sensor unit. Experimental observations and analytical modeling demonstrate that incorporating mushroom-shaped bionic dry adhesive structures with inclined support micropillars can reduce interface contact stiffness, notably enhancing adhesion on rough surfaces while allowing real-time monitoring of contact states. Moreover, this innovative smart adhesive structure facilitates morphology sensing of contact interfaces, presenting potential advancements in bionic adhesion for morphology sensing applications.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0630"},"PeriodicalIF":11.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143503644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Circ-0001283 Aggravates Cardiac Hypertrophy by Targeting Myosin Light Chain 3 Protein.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-25 eCollection Date: 2025-01-01 DOI: 10.34133/research.0626

Wenjing Wang, Lili Chen, Yiheng Zhao, Shuchen Zhang, Xiang Zhou

引用次数: 0

Molecular Mechanism of Oil-Infused Silicone Preventing Mussel Biofouling.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.34133/research.0627

Jian He, Jiawei Li, Yihan Sun, Yuanyuan Shen, Qi Wei, Dun Zhang, Danqing Feng, Peng Wang

{"title":"Molecular Mechanism of Oil-Infused Silicone Preventing Mussel Biofouling.","authors":"Jian He, Jiawei Li, Yihan Sun, Yuanyuan Shen, Qi Wei, Dun Zhang, Danqing Feng, Peng Wang","doi":"10.34133/research.0627","DOIUrl":"10.34133/research.0627","url":null,"abstract":"Marine biofouling causes severe economical and environmental challenges to marine industries and maritime activities. Biofouling prevention has emerged as one of the most pressing issues in water-related industries. Recently, the slippery liquid-infused porous surfaces (SLIPSs) have shown great potential for biofouling prevention across a broad spectrum of fouling organisms. However, our understanding of the mechanisms by which SLIPSs prevent biofouling remains limited. In this study, we discovered that oil-infused polydimethylsiloxane elastomer (i-PDMS), a silicone-based SLIPS variant, significantly inhibited the sensory responses of the fouling mussel Mytilopsis sallei, particularly at its sensory organ, the foot. Using bioinformatics and molecular biology analyses, we demonstrated that i-PDMS disrupts larval settlement of M. sallei by interfering with the mechanosensitive transient receptor potential melastatin-subfamily member 7 (TRPM7) channel, which is highly expressed in the foot during the settlement process. Furthermore, adhesion assays and molecular dynamics simulations revealed that the secreted foot proteins of the mussel are unable to effectively interact with the i-PDMS surface due to nanoscale fluctuations at the material interface. These findings enhance our understanding of how fouling organisms sense and adhere to surfaces and provide deeper insights into the antifouling mechanisms of SLIPS.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0627"},"PeriodicalIF":11.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nano-/Microrobots for Environmental Remediation in the Eyes of Nanoarchitectonics: Toward Engineering on a Single-Atomic Scale.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.34133/research.0624

Anna Jancik-Prochazkova, Katsuhiko Ariga

{"title":"Nano-/Microrobots for Environmental Remediation in the Eyes of Nanoarchitectonics: Toward Engineering on a Single-Atomic Scale.","authors":"Anna Jancik-Prochazkova, Katsuhiko Ariga","doi":"10.34133/research.0624","DOIUrl":"10.34133/research.0624","url":null,"abstract":"Nano-/microrobots have been demonstrated as an efficient solution for environmental remediation. Their strength lies in their propulsion abilities that allow active \"on-the-fly\" operation, such as pollutant detection, capture, transport, degradation, and disruption. Another advantage is their versatility, which allows the engineering of highly functional solutions for a specific application. However, the latter advantage can bring complexity to applications; versatility in dimensionality, morphology, materials, surface decorations, and other modifications has a crucial effect on the resulting propulsion abilities, compatibility with the environment, and overall functionality. Synergy between morphology, materials, and surface decorations and its projection to the overall functionality is the object of nanoarchitectonics. Here, we scrutinize the engineering of nano-/microrobots with the eyes of nanoarchitectonics: we list general concepts that help to assess the synergy and limitations of individual procedures in the fabrication processes and their projection to the operation at the macroscale. The nanoarchitectonics of nano-/microrobots is approached from microscopic level, focusing on the dimensionality and morphology, through the nanoscopic level, evaluating the influence of the decoration with nanoparticles and quantum dots, and moving to the decorations on molecular and single-atomic level to allow very fine tuning of the resulting functionality. The presented review aims to lay general concepts and provide an overview of the engineering of functional advanced nano-/microrobot for environmental remediation procedures and beyond.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0624"},"PeriodicalIF":11.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Learning for Predicting Biomolecular Binding Sites of Proteins.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-24 eCollection Date: 2025-01-01 DOI: 10.34133/research.0615

Minjie Mou, Zhichao Zhang, Ziqi Pan, Feng Zhu

{"title":"Deep Learning for Predicting Biomolecular Binding Sites of Proteins.","authors":"Minjie Mou, Zhichao Zhang, Ziqi Pan, Feng Zhu","doi":"10.34133/research.0615","DOIUrl":"10.34133/research.0615","url":null,"abstract":"The rapid evolution of deep learning has markedly enhanced protein-biomolecule binding site prediction, offering insights essential for drug discovery, mutation analysis, and molecular biology. Advancements in both sequence-based and structure-based methods demonstrate their distinct strengths and limitations. Sequence-based approaches offer efficiency and adaptability, while structure-based techniques provide spatial precision but require high-quality structural data. Emerging trends in hybrid models that combine multimodal data, such as integrating sequence and structural information, along with innovations in geometric deep learning, present promising directions for improving prediction accuracy. This perspective summarizes challenges such as computational demands and dynamic modeling and proposes strategies for future research. The ultimate goal is the development of computationally efficient and flexible models capable of capturing the complexity of real-world biomolecular interactions, thereby broadening the scope and applicability of binding site predictions across a wide range of biomedical contexts.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0615"},"PeriodicalIF":11.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11848751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advanced Nanoprobe Strategies for Imaging Macrophage Polarization in Cancer Immunology.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.34133/research.0622

Junjie Zhang, Kaiyuan Tang, Yongbin Yang, Dongliang Yang, Wenpei Fan

{"title":"Advanced Nanoprobe Strategies for Imaging Macrophage Polarization in Cancer Immunology.","authors":"Junjie Zhang, Kaiyuan Tang, Yongbin Yang, Dongliang Yang, Wenpei Fan","doi":"10.34133/research.0622","DOIUrl":"10.34133/research.0622","url":null,"abstract":"Macrophages are ubiquitous within the human body and serve pivotal roles in immune surveillance, inflammation, and tissue homeostasis. Phenotypic plasticity is a hallmark of macrophages, allowing their polarization into distinct phenotypes M1 (pro-inflammatory, anti-tumor) and M2 (anti-inflammatory, pro-tumor) in response to local microenvironmental cues. In tumor tissues, the polarization of tumor-associated macrophages profoundly shapes the tumor microenvironment, influencing tumor progression, immune evasion, and metastasis. Therefore, the ability to image and monitor macrophage polarization is essential for comprehending tumor biology and optimizing therapeutic strategies. With the rapid advancement of nanomedicine, a diverse array of nanoprobes has been engineered to specifically target tumor-associated macrophages, offering new avenues for noninvasive in vivo imaging and real-time monitoring of macrophage dynamics within the tumor microenvironment. This perspective highlights recent advancements in macrophage-targeting nanoprobes for imaging macrophage polarization both in vitro and in vivo. It also addresses the current challenges in the field, such as enhancing probe sensitivity, specificity, and biocompatibility, while outlining the future directions for the development of next-generation nanoprobes aimed at precision oncology.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0622"},"PeriodicalIF":11.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Study on Digital Light Processing 3D Printing of 0-3 Ceramic Composites for Piezoelectric Metastructures.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI: 10.34133/research.0595

Huiru Wang, Qingbo Lai, Dingcong Zhang, Xin Li, Jiayi Hu, Hongyan Yuan

{"title":"A Systematic Study on Digital Light Processing 3D Printing of 0-3 Ceramic Composites for Piezoelectric Metastructures.","authors":"Huiru Wang, Qingbo Lai, Dingcong Zhang, Xin Li, Jiayi Hu, Hongyan Yuan","doi":"10.34133/research.0595","DOIUrl":"10.34133/research.0595","url":null,"abstract":"Digital light processing (DLP) is a high-speed, high-precision 3-dimensional (3D) printing technique gaining traction in the fabrication of ceramic composites. However, when printing 0-3 composites containing lead zirconate titanate (PZT) particles, a widely used piezoelectric ceramic, severe density and refractive index mismatches between the 2 phases pose challenges for ink synthesis and the printing process. Here, we systematically and quantitatively optimized DLP printing of PZT composites, streamlining process development and providing a solid theoretical and experimental foundation for broader applications of DLP technology. PZT particles were pretreated with air plasma to improve slurry uniformity and enhance stress transfer at the composite interface, leading to improved chemical modification, mechanical strength, and piezoelectric properties. We investigated the effects of key process parameters on printability and accuracy by analyzing the curing behavior of PZT-polymer composites. A quantitative model of the DLP curing process was introduced. Unlike stereolithography (SLA), DLP curing depth was found to depend on energy dose and light intensity, with higher intensities proving more favorable for printing 0-3 PZT composites. From depth/width-energy curves, optimal process parameters were determined. We designed and fabricated a soft piezoelectric metamaterial-based touch sensor using these parameters, achieving a customized output profile. This work offers critical insights into optimizing DLP for functional materials and expands the potential of 3D-printed piezoelectric composites.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0595"},"PeriodicalIF":11.0,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842675/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143483799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research.

IF 11 1区综合性期刊

Research Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI: 10.34133/research.0617

Huiting Jiang, Yukun Liao, Mengliang Zhu, Luksika Jiramonai, Hongyun Wu, Yixin Zhong, Zulong Xie, Xing-Jie Liang

{"title":"Innovative Atherosclerosis Models: Advancing Pathophysiology and Translational Research.","authors":"Huiting Jiang, Yukun Liao, Mengliang Zhu, Luksika Jiramonai, Hongyun Wu, Yixin Zhong, Zulong Xie, Xing-Jie Liang","doi":"10.34133/research.0617","DOIUrl":"10.34133/research.0617","url":null,"abstract":"Atherosclerosis (AS) is a chronic inflammatory condition influenced by glucose and lipid disorders, oxidative stress, and thrombosis, reflecting the complexity of its pathological process. The development of accurate experimental models that simulate human AS is essential for understanding its initiation and progression. This review summarizes the current AS research models and analyzes their specific application scenarios. We discuss tissue-engineered blood vessels (TEBVs) and vessels-on-a-chip (VoCs), which leverage tissue engineering and precise microenvironmental control to construct in vitro models that closely resemble the structure and function of human AS. Isolated vessel segments from live animals provide a valuable tool for investigating human AS due to their physiological similarity, controllability, and reproducibility. The review further outlines the construction of AS animal models through high-fat diets and gene-editing techniques, highlighting how immune-inflammatory responses, mechanical arterial injury, and hemodynamic changes accelerate model development. This comprehensive analysis highlights the potential of AS models to revolutionize theranostic applications in clinical translational research, paving the way for more personalized and effective treatments for AS in the near future.","PeriodicalId":21120,"journal":{"name":"Research","volume":"8 ","pages":"0617"},"PeriodicalIF":11.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart Failure and Gut Microbiota: What Is Cause and Effect?

IF 11 1区综合性期刊

Research Pub Date : 2025-02-20 eCollection Date: 2025-01-01 DOI: 10.34133/research.0610

Shichun Shen, Beiduo Tian, Haizhu Zhang, Yu-Chen Wang, Tao Li, Yang Cao

引用次数: 0