肠-脑-微生物轴在肿瘤免疫逃逸和免疫治疗中的调控作用。

IF 10.7 1区综合性期刊 Q1 Multidisciplinary

Research Pub Date : 2025-09-11 eCollection Date: 2025-01-01 DOI:10.34133/research.0885

Wangting Xu, Qifan Xu, Peng Luo, Xudong Qu, Dandan Guo, Zhao Xie, Na Hang, Minjie Kuang, Enguo Chen, Ling Wang, Zhiping Yan, Songhua Cai, Wenjun Mao, Bufu Tang

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引用次数: 0

摘要

越来越多的证据表明，肠和脑之间存在相互作用，而肠道微生物群是这种相互作用的关键中介。肠道菌群及其衍生代谢物和生物活性化合物通过肠-脑轴调节脑肿瘤的免疫微环境，从而影响肿瘤的发生、进展、侵袭和转移。本文系统地总结了脑肿瘤肠-脑轴调节的病理生理机制，并探讨了新兴的治疗方法，包括免疫治疗和靶向治疗的进展，这些方法有望为未来的脑肿瘤治疗策略带来希望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gut-Brain-Microbiome Axis in the Regulation of Cancer Immune Escape and Immunotherapy in Tumors.

Accumulating evidence demonstrates crosstalk involving the intestine and the brain, with the gut microbiota serving as a critical mediator of this interaction. The gut microbiota, along with its derived metabolites and bioactive compounds, modulates the immune microenvironment of brain tumors via the gut-brain axis, thereby influencing tumor initiation, progression, invasion, and metastasis. This review systematically summarizes the pathophysiological mechanisms underlying gut-brain axis modulation of brain tumors and examines emerging therapeutic approaches, including advances in immunotherapy and targeted therapy, that hold promise for future brain tumor treatment strategies.

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来源期刊

Research Multidisciplinary-Multidisciplinary

CiteScore

13.40

自引率

3.60%

发文量

审稿时长

14 weeks

期刊介绍： Research serves as a global platform for academic exchange, collaboration, and technological advancements. This journal welcomes high-quality research contributions from any domain, with open arms to authors from around the globe. Comprising fundamental research in the life and physical sciences, Research also highlights significant findings and issues in engineering and applied science. The journal proudly features original research articles, reviews, perspectives, and editorials, fostering a diverse and dynamic scholarly environment.