Cell Reports Physical Science最新文献

DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid. 羟甲基-γ尾部钳肽核酸的DNA识别和诱导基因组修饰。

IF 7.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-10-18 DOI: 10.1016/j.xcrp.2023.101635

Stanley N Oyaghire, Elias Quijano, J Dinithi R Perera, Hanna K Mandl, W Mark Saltzman, Raman Bahal, Peter M Glazer

{"title":"DNA recognition and induced genome modification by a hydroxymethyl-γ tail-clamp peptide nucleic acid.","authors":"Stanley N Oyaghire, Elias Quijano, J Dinithi R Perera, Hanna K Mandl, W Mark Saltzman, Raman Bahal, Peter M Glazer","doi":"10.1016/j.xcrp.2023.101635","DOIUrl":"10.1016/j.xcrp.2023.101635","url":null,"abstract":"Peptide nucleic acids (PNAs) can target and stimulate recombination reactions in genomic DNA. We have reported that γPNA oligomers possessing the diethylene glycol γ-substituent show improved efficacy over unmodified PNAs in stimulating recombination-induced gene modification. However, this structural modification poses a challenge because of the inherent racemization risk in O-alkylation of the precursory serine side chain. To circumvent this risk and improve γPNA accessibility, we explore the utility of γPNA oligomers possessing the hydroxymethyl-γ moiety for gene-editing applications. We demonstrate that a γPNA oligomer possessing the hydroxymethyl modification, despite weaker preorganization, retains the ability to form a hybrid with the double-stranded DNA target of comparable stability and with higher affinity than that of the diethylene glycol-γPNA. When formulated into poly(lactic-co-glycolic acid) nanoparticles, the hydroxymethyl-γPNA stimulates higher frequencies (≥ 1.5-fold) of gene modification than the diethylene glycol γPNA in mouse bone marrow cells.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"4 10","pages":""},"PeriodicalIF":7.9,"publicationDate":"2023-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10621889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71421048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coupling of alkynes and aryl halides with nickel-catalyzed Sonogashira reactions 炔和芳卤化合物与镍催化Sonogashira反应的偶联

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-09-01 DOI: 10.1016/j.xcrp.2023.101573

Hui Chen, Licheng Yao, Lin Guo, Yahu A. Liu, Boxue Tian, Xuebin Liao

引用次数: 0

Passive radiative cooling to sub-ambient temperatures inside naturally ventilated buildings 在自然通风的建筑物内，被动辐射冷却至低于环境温度

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-09-01 DOI: 10.1016/j.xcrp.2023.101570

Remy Fortin, Jyotirmoy Mandal, A. Raman, S. Craig

引用次数: 1

Non-layered dysprosium oxysulfide as an electron-withdrawing chainmail for promoting electrocatalytic oxygen evolution 非层状氧硫化镝作为促进电催化析氧的吸电子链

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-09-01 DOI: 10.1016/j.xcrp.2023.101571

Xue‐Feng Zhang, Hong-Hong Zou, Li-Weng Ding, Xiao-Xiao Deng, Jia-Jun Zheng, Han-Feng Liu, Zi-Ming Ye, Shengliang Zhong, Ziyan Du, Jia Zhang, Chun-Ting He

引用次数: 0

Lead-sulfur interaction induced damp and water stability in pure formamidinium lead triiodide. 铅硫相互作用诱导纯甲脒型三碘化铅的湿稳定性和水稳定性。

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-16 DOI: 10.1016/j.xcrp.2023.101516

Muhammed P U Haris, Eliseo Ruiz, Samrana Kazim, Shahzada Ahmad

{"title":"Lead-sulfur interaction induced damp and water stability in pure formamidinium lead triiodide.","authors":"Muhammed P U Haris, Eliseo Ruiz, Samrana Kazim, Shahzada Ahmad","doi":"10.1016/j.xcrp.2023.101516","DOIUrl":"https://doi.org/10.1016/j.xcrp.2023.101516","url":null,"abstract":"Research efforts in various multitudes have been demonstrated to stabilize methylammonium (MA)- and bromide (Br)-free formamidinium lead triiodide (FAPI) perovskite thin films. Despite these commendable efforts, pure FAPI perovskite thin film is prone to critical phase-transition issues due to its thermodynamically stable non-perovskite phase (2H). Here, in this work, we propose a rational additivization strategy to overcome this challenge. Our multifunctional ammonium salt containing a sulfur heteroatom shifts the thermodynamic stability from the 2H phase to an intermediate phase closer to the cubic phase. Along with the high crystallinity, micron-sized grains with preferred (00h) facet orientation stem the Pb…S interaction to offer exceptional stability against high relative humidity, direct water incursion, and shelf-life aging. Our findings through experimental and theoretical studies substantiate the role of Pb…S interaction in stabilizing the perovskite cubic phase and the stoichiometric distribution of elemental components.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"4 8","pages":"101516"},"PeriodicalIF":8.9,"publicationDate":"2023-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10450572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10109281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Origin of rate limitations in solid-state polymer batteries from constrained segmental dynamics within the cathode 固态聚合物电池速率限制的来源:阴极内受限的节段动力学

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-01 DOI: 10.1016/j.xcrp.2023.101538

X. C. Chen, Charles Soulen, Mary K. Burdette-Trofimov, Xiaomin Tang, Changhao Liu, L. Heroux, M. Doucet, M. Tyagi, G. Veith

引用次数: 0

Ligand “lock and fix” strategy provides stability to metal-organic frameworks for photodegradation processes 配体“锁定和固定”策略为光降解过程的金属有机框架提供稳定性

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-01 DOI: 10.1016/j.xcrp.2023.101545

Fangdi Dong, Xu Wang, Zhiqiang Zhao, Shuai Gao, Guo Wang, Kai Li, Yuqing Lin

引用次数: 0

Photoelectrochemical Si–H and Ge–H activation by iron catalysis 铁催化的光电化学Si–H和Ge–H活化

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-01 DOI: 10.1016/j.xcrp.2023.101550

W. Wei, Simon L Homölle, Tristan von Münchow, Yanjun Li, Isaac Maksso, L. Ackermann

引用次数: 0

Impact of dipolar molecules on the reliability of organic photovoltaic cells 偶极分子对有机光伏电池可靠性的影响

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-01 DOI: 10.1016/j.xcrp.2023.101551

Xinjing Huang, Yongxi Li, S. Forrest

引用次数: 0

Rational positioning of 3D-printed voxels to realize high-fidelity multifunctional soft-hard interfaces 三维打印体素的合理定位实现高保真多功能软硬界面

IF 8.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2023-08-01 DOI: 10.1016/j.xcrp.2023.101552

M. C. Saldívar, Shima Salehi, Robin Petrus Elias Veeger, E. Tay, M. Fenu, A. Cantamessa, M. Klimopoulou, G. Talò, M. Moretti, S. Lopa, D. Ruffoni, G. V. van Osch, L. Fratila-Apachitei, Zjenja Doubrovski, M. Mirzaali, A. A. Zadpoor

引用次数: 0