Cell Reports Physical Science最新文献

Photosystem I structural fusion with IsiA enhances light-harvesting capabilities of filamentous cyanobacterium during iron deficiency. 光系统I与IsiA的结构融合增强了丝状蓝藻在缺铁条件下的捕光能力。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-09-16 Epub Date: 2026-09-02 DOI: 10.1016/j.xcrp.2026.103524

Sandeep Biswas, Dariusz M Niedzwiedzki, Kuo-En Chen, Ranel Maqdisi, Yuval Mazor, Himadri B Pakrasi

{"title":"Photosystem I structural fusion with IsiA enhances light-harvesting capabilities of filamentous cyanobacterium during iron deficiency.","authors":"Sandeep Biswas, Dariusz M Niedzwiedzki, Kuo-En Chen, Ranel Maqdisi, Yuval Mazor, Himadri B Pakrasi","doi":"10.1016/j.xcrp.2026.103524","DOIUrl":"https://doi.org/10.1016/j.xcrp.2026.103524","url":null,"abstract":"During iron stress, cyanobacteria produce iron-stress-inducible protein A (IsiA), which associates with photosystem I (PSI) to support cell growth. In most cyanobacteria, the stress induces formation of large IsiA18-PSI3 complexes. However, some species, including Anabaena sp. PCC 7120, studied in this work, form an unusual, smaller PSI-monomer-based IsiA-PSI supercomplex containing a unique fusion of IsiA with the PSI subunit PsaL, IsiA-PsaL. In this study, genetically tagged IsiA-PsaL was used to isolate several IsiA-PsaL-containing supercomplexes composed of multiple IsiA homologs. A combination of static and time-resolved optical spectroscopies was used to evaluate the energetic properties of gel-embedded supercomplexes, including the excitation energy transfer efficiency from IsiA-PsaL to PSI. These analyses demonstrated that excitation energy transfer in the IsiA-PsaL complex is highly efficient. Enhanced efficiency may be a key factor underlying the downsizing of the IsiA-PSI assembly, which could compensate for the smaller size of the complex.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 9","pages":"103524"},"PeriodicalIF":6.9,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13637498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Matrix degradation promotes fibronectin deposition and spatial remodeling in 3D. 基质降解促进纤维连接蛋白沉积和三维空间重塑。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-08-19 Epub Date: 2026-08-07 DOI: 10.1016/j.xcrp.2026.103489

Rabeya Sharmin Lima, Caleb Morrill, Haley A Royce, Claire Komar, Yang Hu, Linqing Li

{"title":"Matrix degradation promotes fibronectin deposition and spatial remodeling in 3D.","authors":"Rabeya Sharmin Lima, Caleb Morrill, Haley A Royce, Claire Komar, Yang Hu, Linqing Li","doi":"10.1016/j.xcrp.2026.103489","DOIUrl":"10.1016/j.xcrp.2026.103489","url":null,"abstract":"The extracellular matrix (ECM) coordinates the interplay between biochemical and biophysical cues to regulate cell behavior, yet isolating their individual contributions remains difficult as they are interdependent in native tissues. Here, we present a modular hydrogel platform that independently controls growth factor delivery and user-defined enzymatic matrix degradation. We show that matrix degradation alone, in the absence of exogenous growth factors, is sufficient to drive cell spreading, migration, and fibronectin deposition and assembly. Growth factor stimulation enhanced spheroid expansion but did not induce organized fibronectin remodeling unless combined with matrix degradation. Mechanistic inhibitor studies revealed that degradation-enabled fibronectin remodeling is primarily contractility dependent and MMP independent. These results support a feedback model wherein matrix degradation creates a permissive microenvironment for cell migration and fibronectin deposition, reinforcing focal adhesion formation, cell contractility, and further ECM assembly. This work identifies matrix degradation as an instructive regulator of fibronectin deposition, assembly, and remodeling, offering a framework for designing dynamic hydrogels that emulate tissue remodeling during development and healing.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 8","pages":"103489"},"PeriodicalIF":6.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13576474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immobilization method dictates the photoelectrochemical glycerol oxidation performance of semiconductor catalyst assemblies. 固定化方法决定了半导体催化剂组件的光电氧化甘油性能。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-08-19 DOI: 10.1016/j.xcrp.2026.103475

Ádám Balog, Gergely Ferenc Samu, Dávid Fekete, Cintia Hajdu, Norbert Varga, Edit Csapó, Csaba Janáky

{"title":"Immobilization method dictates the photoelectrochemical glycerol oxidation performance of semiconductor catalyst assemblies.","authors":"Ádám Balog, Gergely Ferenc Samu, Dávid Fekete, Cintia Hajdu, Norbert Varga, Edit Csapó, Csaba Janáky","doi":"10.1016/j.xcrp.2026.103475","DOIUrl":"https://doi.org/10.1016/j.xcrp.2026.103475","url":null,"abstract":"Photoelectrochemistry provides a direct route to convert sunlight into valuable chemicals. However, high-performance photoelectrode architectures often require complicated synthesis steps and expensive instrumentation. Although physical immobilization (e.g., spray coating) of catalyst particles on semiconductors seems to be a simple and universal approach, it is rarely implemented to prepare photoelectrodes. Here, we highlight challenges associated with such deposition strategies and demonstrate the importance of rational photoelectrode design. Specifically, we introduce metal interlayers (Pd, Au, or Ni) between n-type Si and a spray-coated PdAu catalyst. We show that these interlayers are essential for generating photopotential at the interface, while the PdAu catalyst governs C3 selectivity during glycerol oxidation. We also demonstrate that the interlayer determines key performance metrics (e.g., photopotential, photocurrent density, and stability). With this approach, the best-performing PdAu/Au/Si and PdAu/Ni/Si photoelectrodes can deliver high reaction rates (>100 mA cm-2) with sufficient stability even at higher illumination intensities (50 suns).","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 8","pages":"103475"},"PeriodicalIF":6.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum: Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics. 用于临床前肿瘤靶向纳米治疗的生物启发和仿生癌细胞来源的膜纳米囊泡。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-08-19 DOI: 10.1016/j.xcrp.2026.103459

Rajendra Prasad, Bárbara B Mendes, Mahadeo Gorain, Gopal Chandra Kundu, Narendra Gupta, Berney Peng, Eaint Honey Aung Win, He Qing, João Conde

引用次数: 0

Explainable AI reveals the allosteric blind spot in protein-ligand binding predictions. 可解释的AI揭示了蛋白质-配体结合预测中的变构盲点。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-08-19 Epub Date: 2026-07-22 DOI: 10.1016/j.xcrp.2026.103448

Vedant Parikh, Brandon Foley, Will Gatlin, Max Ludwick, Lucas Turano, Gennady M Verkhivker

{"title":"Explainable AI reveals the allosteric blind spot in protein-ligand binding predictions.","authors":"Vedant Parikh, Brandon Foley, Will Gatlin, Max Ludwick, Lucas Turano, Gennady M Verkhivker","doi":"10.1016/j.xcrp.2026.103448","DOIUrl":"10.1016/j.xcrp.2026.103448","url":null,"abstract":"Artificial intelligence (AI) has transformed prediction of protein structure and interactions, yet modeling of allosteric binding remains a persistent challenge. We develop an explainable AI framework that interrogates AI models AlphaFold3, Protenix, Boltz-2, Chai-1, and DynamicBind on rigorously stratified datasets of orthosteric and allosteric ligand-protein complexes. While AI models excel in accurate modeling of orthosteric ligand binding, a consistent and substantial performance gap observed across diverse architectures emerges in prediction of allosteric complexes. The biophysical logic for this dichotomy is unveiled through physics-based lens of the energy landscape theory. Orthosteric binding creates dominant energetic funnels via ligand-induced minimal frustration quenching, while allosteric sites preserve neutral frustration landscapes in both apo and holo protein states. By linking prediction outcomes to frustration landscapes, this study recasts AI shortcomings in prediction of allosteric ligand binding as diagnostic indicators of allostery, establishing a physics-informed framework that turns the allosteric blind spot into mechanistic insight.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 8","pages":"103448"},"PeriodicalIF":6.9,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13560746/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic insights into how water-network disorder determines the vitrification concentration in cryopreservation solutions. 水网络紊乱如何决定低温保存溶液中玻璃化浓度的机制见解。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-05-20 DOI: 10.1016/j.xcrp.2026.103282

Euihyun Lee, Nora Gaby-Biegel, Rebecca D Sandlin, Carlos R Baiz

{"title":"Mechanistic insights into how water-network disorder determines the vitrification concentration in cryopreservation solutions.","authors":"Euihyun Lee, Nora Gaby-Biegel, Rebecca D Sandlin, Carlos R Baiz","doi":"10.1016/j.xcrp.2026.103282","DOIUrl":"10.1016/j.xcrp.2026.103282","url":null,"abstract":"Cryopreservation enables long-term storage of biological materials using cryoprotective agents (CPAs) to suppress ice crystal formation and prevent cell damage. However, despite considerable efforts, a molecular-level understanding of how CPAs prevent ice-crystal formation has not yet been established, particularly one that generalizes across different CPAs. In this study, we correlate molecular factors derived from low-temperature molecular dynamics simulations with measured Cv (minimum concentration required for vitrification) across several CPAs. Specifically, tetrahedral order parameter analyses show that CPAs disrupt the natural tetrahedral structure of water to different degrees, and this disruption correlates strongly with Cv. Additionally, we show that clustering predicts Cv, relating CPA-induced changes in the H-bond network to vitrification ability. We establish a molecular connection between CPA-driven disruption of the water H-bond network and vitrification capability. We use this to predict the CPA efficiency of new compounds. The approach provides a route toward the first-principles design of effective CPA compositions.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 5","pages":""},"PeriodicalIF":6.9,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148327249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Color-tunable luminescent Tb_xEu_y(BDC) complexes assembled within liposome-based nanoreactors. 脂质体纳米反应器中可调色发光TbxEuy（BDC）配合物的组装。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-05-20 DOI: 10.1016/j.xcrp.2026.103312

Aaron Torres-Huerta, Miriam de J Velásquez-Hernández, Sven Lempereur, Ludovic Troian-Gautier, Giulia Veronesi, Hennie Valkenier

{"title":"Color-tunable luminescent TbxEuy(BDC) complexes assembled within liposome-based nanoreactors.","authors":"Aaron Torres-Huerta, Miriam de J Velásquez-Hernández, Sven Lempereur, Ludovic Troian-Gautier, Giulia Veronesi, Hennie Valkenier","doi":"10.1016/j.xcrp.2026.103312","DOIUrl":"10.1016/j.xcrp.2026.103312","url":null,"abstract":"Precise stoichiometric control in multimetallic lanthanide nanosystems is essential for optical devices, sensing, and bioimaging applications owing to their composition-dependent emission properties. However, controlling metal composition, spatial distribution, intermetallic energy transfer, and colloidal stability remains challenging. Here, we report a liposome-based nanoreactor platform that enables the in situ formation of multivariate TbxEuy-dicarboxylate complexes, enabling finely tuned lanthanide stoichiometry within attoliter-scale confined volumes. Liposomes pre-loaded with specific Tb3+:Eu3+ ratios are combined with a synthetic anion transporter that mediates dicarboxylate transport through lipid membranes, enabling controlled coordination reactions in aqueous solution. This method, coupled with the use of a blue-emissive ligand, supports continuous color tuning across the entire RGB spectrum. Real-time emission spectroscopy reveals faster photoluminescence appearance for Eu3+ than Tb3+, providing experimental insight into lanthanide reactivity under nanoscale confinement. These findings position liposome-based nanoreactors as a versatile platform for investigating coordination reactions and engineering multimetallic luminescent colloidal materials in aqueous media.","PeriodicalId":9703,"journal":{"name":"Cell Reports Physical Science","volume":"7 5","pages":"103312"},"PeriodicalIF":6.9,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190561/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148013627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active regulation of intrinsic curvature by eukaryotic phospholipid metabolism. 真核磷脂代谢对内在曲率的主动调节。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-05-20 DOI: 10.1016/j.xcrp.2026.103277

Daniel Milshteyn, Jacob R Winnikoff, Elida Kocharian, Aaron M Armando, Edward A Dennis, Peter R Girguis, Itay Budin

引用次数: 0

Exploiting anti-mitotic therapy as a cell cycle-responsive strategy to enhance nano-agent retention in tumor cells 利用抗有丝分裂治疗作为细胞周期响应策略来增强纳米药物在肿瘤细胞中的保留

2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-05-01 DOI: 10.1016/j.xcrp.2026.103307

Feifan Zhao, Jinglin Wu, Xinyuan Li, Bowen Zhang, Wei Zhang, Jin Li, Yan Liu

引用次数: 0

Tough adhesive bilayer hydrogels. 坚韧的粘接双层水凝胶。

IF 6.9 2区综合性期刊

Cell Reports Physical Science Pub Date : 2026-04-15 DOI: 10.1016/j.xcrp.2026.103232

Elise Ansart, Nicolas Hesse, Junsoo Kim, David J Mooney, Benjamin R Freedman

引用次数: 0