Chemiosmotic ATP synthesis by minimal protocells.

IF 7.9 2区 综合性期刊 Q1 CHEMISTRY, MULTIDISCIPLINARY
Fanchen Yu, Jinbo Fei, Yi Jia, Tonghui Wang, William F Martin, Junbai Li
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引用次数: 0

Abstract

Energy conservation is crucial to life's origin and evolution. The common ancestor of all cells used ATP synthase to convert proton gradients into ATP. However, pumps generating proton gradients and lipids maintaining proton gradients are not universally conserved across all lineages. A solution to this paradox is that ancestral ATP synthase could harness naturally formed geochemical ion gradients with simpler environmentally provided precursors preceding both proton pumps and biogenic membranes. This runs counter to traditional views that phospholipid bilayers are required to maintain proton gradients. Here, we show that fatty acid membranes can maintain sufficient proton gradients to synthesize ATP by ATP synthase under the steep pH and temperature gradients observed in hydrothermal vent systems. These findings shed substantial light on early membrane bioenergetics, uncovering a functional intermediate in the evolution of chemiosmotic ATP synthesis during protocellular stages postdating the ATP synthase's origin but preceding the advent of enzymatically synthesized cell membranes.

最小原始细胞的化学渗透ATP合成。
节约能源对生命的起源和进化至关重要。所有细胞的共同祖先使用ATP合酶将质子梯度转化为ATP。然而,产生质子梯度的泵和维持质子梯度的脂质并不是在所有谱系中普遍保守的。这个悖论的一个解决方案是,祖先的ATP合酶可以利用自然形成的地球化学离子梯度,在质子泵和生物膜之前,有更简单的环境提供的前体。这与磷脂双分子层是维持质子梯度所必需的传统观点背道而驰。在热液喷口系统中,脂肪酸膜可以在陡峭的pH和温度梯度下维持足够的质子梯度,通过ATP合酶合成ATP。这些发现揭示了早期膜生物能量学,揭示了在原细胞阶段化学渗透ATP合成进化中的一种功能中间体,这种中间体在ATP合酶起源之后,但在酶合成细胞膜出现之前。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cell Reports Physical Science
Cell Reports Physical Science Energy-Energy (all)
CiteScore
11.40
自引率
2.20%
发文量
388
审稿时长
62 days
期刊介绍: Cell Reports Physical Science, a premium open-access journal from Cell Press, features high-quality, cutting-edge research spanning the physical sciences. It serves as an open forum fostering collaboration among physical scientists while championing open science principles. Published works must signify significant advancements in fundamental insight or technological applications within fields such as chemistry, physics, materials science, energy science, engineering, and related interdisciplinary studies. In addition to longer articles, the journal considers impactful short-form reports and short reviews covering recent literature in emerging fields. Continually adapting to the evolving open science landscape, the journal reviews its policies to align with community consensus and best practices.
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