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Tropical forest’s last old growth is being toppled — illegally
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00506-4
{"title":"Tropical forest’s last old growth is being toppled — illegally","authors":"","doi":"10.1038/d41586-025-00506-4","DOIUrl":"https://doi.org/10.1038/d41586-025-00506-4","url":null,"abstract":"Satellite imagery helps to identify two hotspots of deforestation in the Atlantic Forest along Brazil’s eastern coast.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"20 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How AI is revealing the language of the birds
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00539-9
{"title":"How AI is revealing the language of the birds","authors":"","doi":"10.1038/d41586-025-00539-9","DOIUrl":"https://doi.org/10.1038/d41586-025-00539-9","url":null,"abstract":"Crows make a huge number of different sounds; Articifical Inelligence could help us understand what they mean.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"85 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asteroid 2024 YR4 now unlikely to hit Earth — but scientists are ready for future threats
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00552-y
{"title":"Asteroid 2024 YR4 now unlikely to hit Earth — but scientists are ready for future threats","authors":"","doi":"10.1038/d41586-025-00552-y","DOIUrl":"https://doi.org/10.1038/d41586-025-00552-y","url":null,"abstract":"Objects that could strike will be spotted more regularly as new asteroid-hunting telescopes come online.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"209 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer evolution could inform targets for personalized anticancer vaccines
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00467-8
{"title":"Cancer evolution could inform targets for personalized anticancer vaccines","authors":"","doi":"10.1038/d41586-025-00467-8","DOIUrl":"https://doi.org/10.1038/d41586-025-00467-8","url":null,"abstract":"Treatment-resistance mechanisms identified through longitudinal analysis of cancer clones.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"28 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What sparked the COVID pandemic? Mounting evidence points to raccoon dogs
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00426-3
{"title":"What sparked the COVID pandemic? Mounting evidence points to raccoon dogs","authors":"","doi":"10.1038/d41586-025-00426-3","DOIUrl":"https://doi.org/10.1038/d41586-025-00426-3","url":null,"abstract":"More than five years on, studies suggest the animal is the most likely culprit, but other candidates haven't been ruled out.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"23 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Putting early cancer detection to the test
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00530-4
{"title":"Putting early cancer detection to the test","authors":"","doi":"10.1038/d41586-025-00530-4","DOIUrl":"https://doi.org/10.1038/d41586-025-00530-4","url":null,"abstract":"Identifying tumours using blood samples is possible, but researchers are still working out how to validate and deploy multi-cancer tests.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"20 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How to bring health and happiness to your lab
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00538-w
{"title":"How to bring health and happiness to your lab","authors":"","doi":"10.1038/d41586-025-00538-w","DOIUrl":"https://doi.org/10.1038/d41586-025-00538-w","url":null,"abstract":"Can mindfulness, meditation and other tools designed to boost well-being make a difference? Adam Levy investigates.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"66 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stories of people, past, present and future: Books in brief 关于过去、现在和未来的人物故事：书籍简介
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-21 DOI: 10.1038/d41586-025-00555-9
{"title":"Stories of people, past, present and future: Books in brief","authors":"","doi":"10.1038/d41586-025-00555-9","DOIUrl":"https://doi.org/10.1038/d41586-025-00555-9","url":null,"abstract":"Andrew Robinson reviews five of the best science picks.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trump’s siege of science: how the first 30 days unfolded and what’s next
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-20 DOI: 10.1038/d41586-025-00525-1
{"title":"Trump’s siege of science: how the first 30 days unfolded and what’s next","authors":"","doi":"10.1038/d41586-025-00525-1","DOIUrl":"https://doi.org/10.1038/d41586-025-00525-1","url":null,"abstract":"The breakneck pace and devastating impact of the administration’s policy changes has researchers shocked.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"181 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143452262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural dynamics of human fatty acid synthase in the condensing cycle
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-02-20 DOI: 10.1038/s41586-025-08782-w
Wooyoung Choi, Chengmin Li, Yifei Chen, Yongqiang Wang, Yifan Cheng
{"title":"Structural dynamics of human fatty acid synthase in the condensing cycle","authors":"Wooyoung Choi, Chengmin Li, Yifei Chen, Yongqiang Wang, Yifan Cheng","doi":"10.1038/s41586-025-08782-w","DOIUrl":"https://doi.org/10.1038/s41586-025-08782-w","url":null,"abstract":"<p>Long chain fatty acids are the building blocks of fat in human bodies. In mammals, fatty acid synthase (FASN) contains multiple enzymatic domains to catalyze all chemical reactions needed for <i>de novo</i> fatty acid synthesis<sup>1</sup>. While the chemical reactions carried out by these enzymatic domains are well defined, how the dimeric FASN with an open architecture continuously catalyzes such reactions to synthesize a complete fatty acid remains elusive. Here, using a strategy of tagging and purifying endogenous FASN in HEK293 for single particle cryogenic electron microscopy studies, we characterized the structural dynamics of endogenous human FASN. We captured the conformational snapshots of various functional substates in the condensing cycle and developed a procedure to analyze particle distribution landscape of FASN with different orientations between its condensing and modifying wings. Together, we reveal that FASN function does not require large rotational motion between its two major functional domains during the condensing cycle, and that the catalytic reactions in condensing cycle carried out by two monomers are unsynchronized. Our data thus provide a new composite view of FASN dynamics during the fatty acid synthesis condensing cycle.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"127 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143462138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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