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Is academic research becoming too competitive? Nature examines the data. 学术研究的竞争是否变得过于激烈？《自然》杂志分析了这些数据。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-17 DOI: 10.1038/d41586-025-03119-z
Miryam Naddaf
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引用次数: 0
Time-resolved fluorescent proteins expand the microscopy palette. 时间分辨荧光蛋白扩展了显微镜的调色板。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-17 DOI: 10.1038/d41586-025-03318-8
Stephanie Melchor
{"title":"Time-resolved fluorescent proteins expand the microscopy palette.","authors":"Stephanie Melchor","doi":"10.1038/d41586-025-03318-8","DOIUrl":"https://doi.org/10.1038/d41586-025-03318-8","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"19 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Warning signs.
IF 48.5 1区 综合性期刊
Nature Pub Date : 2025-10-17 DOI: 10.1038/d41586-025-03255-6
Alan Dove
{"title":"Warning signs.","authors":"Alan Dove","doi":"10.1038/d41586-025-03255-6","DOIUrl":"https://doi.org/10.1038/d41586-025-03255-6","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":48.5,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145313289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Would ChatGPT hire you? Your age and gender matter. ChatGPT会雇佣你吗？你的年龄和性别很重要。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-17 DOI: 10.1038/d41586-025-03413-w
Shamini Bundell
{"title":"Would ChatGPT hire you? Your age and gender matter.","authors":"Shamini Bundell","doi":"10.1038/d41586-025-03413-w","DOIUrl":"https://doi.org/10.1038/d41586-025-03413-w","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"44 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Author Correction: A room temperature rechargeable all-solid-state hydride ion battery. 作者更正：室温可充电全固态氢化物离子电池。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-17 DOI: 10.1038/s41586-025-09701-9
Jirong Cui,Ren Zou,Weijin Zhang,Hong Wen,Jingyao Liu,Shangshang Wang,Shukun Liu,Hetong Chen,Wei Liu,Xiaohua Ju,Weiwei Wang,Tao Gan,Jiong Li,Jianping Guo,Teng He,Hujun Cao,Ping Chen
{"title":"Author Correction: A room temperature rechargeable all-solid-state hydride ion battery.","authors":"Jirong Cui,Ren Zou,Weijin Zhang,Hong Wen,Jingyao Liu,Shangshang Wang,Shukun Liu,Hetong Chen,Wei Liu,Xiaohua Ju,Weiwei Wang,Tao Gan,Jiong Li,Jianping Guo,Teng He,Hujun Cao,Ping Chen","doi":"10.1038/s41586-025-09701-9","DOIUrl":"https://doi.org/10.1038/s41586-025-09701-9","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"138 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The problem with career planning in science. 科学领域职业规划的问题。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-16 DOI: 10.1038/d41586-025-02900-4
Julie Gould
{"title":"The problem with career planning in science.","authors":"Julie Gould","doi":"10.1038/d41586-025-02900-4","DOIUrl":"https://doi.org/10.1038/d41586-025-02900-4","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"12 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parenting, illnesses and medical commitments: the private details grant reviewers shouldn't need to know. 育儿、疾病和医疗承诺：拨款审查员不需要知道的私人细节。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-16 DOI: 10.1038/d41586-025-02913-z
Nathalie Bock
{"title":"Parenting, illnesses and medical commitments: the private details grant reviewers shouldn't need to know.","authors":"Nathalie Bock","doi":"10.1038/d41586-025-02913-z","DOIUrl":"https://doi.org/10.1038/d41586-025-02913-z","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"27 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145305540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
This gene causes obesity - and shields against heart disease. 这种基因会导致肥胖，并预防心脏病。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-16 DOI: 10.1038/d41586-025-03387-9
Heidi Ledford
{"title":"This gene causes obesity - and shields against heart disease.","authors":"Heidi Ledford","doi":"10.1038/d41586-025-03387-9","DOIUrl":"https://doi.org/10.1038/d41586-025-03387-9","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"55 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global health is in crisis - who will step in to fix it? 全球卫生处于危机之中——谁将介入解决它？
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-16 DOI: 10.1038/d41586-025-03384-y
Fred Schwaller
{"title":"Global health is in crisis - who will step in to fix it?","authors":"Fred Schwaller","doi":"10.1038/d41586-025-03384-y","DOIUrl":"https://doi.org/10.1038/d41586-025-03384-y","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"99 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145311475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization. 保守的h3k14ub驱动H3K9me3染色质区隔化。
IF 64.8 1区 综合性期刊
Nature Pub Date : 2025-10-15 DOI: 10.1038/s41586-025-09624-5
Yuanyong Huang,Yimei Sun,Hongyun Qi,Quanlong Jiang,Jialun Li,Mingzhi Chang,Xinyan Li,Lei Shu,Xiaoya Duan,Yiqin Wang,Kailun Fang,Hailei Mao,Mengmeng Han,Yuan Weng,Qiao Zhang,Zhaosu Chen,Wei Wei,Gaojie Song,Qiansen Zhang,Jiwen Li,Jing-Dong J Han,Charlie Degui Chen,Jiemin Wong
{"title":"A conserved H3K14ub-driven H3K9me3 for chromatin compartmentalization.","authors":"Yuanyong Huang,Yimei Sun,Hongyun Qi,Quanlong Jiang,Jialun Li,Mingzhi Chang,Xinyan Li,Lei Shu,Xiaoya Duan,Yiqin Wang,Kailun Fang,Hailei Mao,Mengmeng Han,Yuan Weng,Qiao Zhang,Zhaosu Chen,Wei Wei,Gaojie Song,Qiansen Zhang,Jiwen Li,Jing-Dong J Han,Charlie Degui Chen,Jiemin Wong","doi":"10.1038/s41586-025-09624-5","DOIUrl":"https://doi.org/10.1038/s41586-025-09624-5","url":null,"abstract":"Compartmentalization of eukaryotic genome into euchromatin and heterochromatin is of critical biological significance1-3. Previous studies have suggested a self-templating pathway involving the reading and writing of histone H3 lysine 9 methylation by SUV39H as the core mechanism for heterochromatin reassembly during cell division1,3. In fission yeast, the mammalian SUV39H homologue Clr4 forms a complex containing ubiquitin ligase Cul4, which catalyses H3K14 mono-ubiquitination (H3K14ub) to promote heterochromatin formation. However, whether heterochromatin reassembly in dividing mammalian cells involves a similar pathway is unknown. Here we identified G2E3 as an H3K14ub-specific, pericentromeric heterochromatin-localized E3 ligase. G2E3-catalysed H3K14ub potentiates histone H3 lysine 9 trimethylation (H3K9me3) by SUV39H and is specifically required for SUV39H compartmentalization and H3K9me3 in pericentromeric heterochromatin. Mechanistically, we found that G2E3 is highly expressed in G2/M phase and associates with mitotic chromosomes in an RNA-dependent manner to catalyse H3K14ub, which is essential for the subsequent sequential recruitment of SUV39H and HP1. The SUV39H chromodomain is a reader of dual H3K9me3 and H3K14ub modifications and SUV39H associates with pericentromeric heterochromatin primarily through its H3K14ub-binding activity. Notably, loss of G2E3 severely impairs pericentromeric heterochromatin organization and results in the aberrant accumulation of SUV39H and H3K9me3 in numerous euchromatin regions and widespread transcriptional repression. Thus, our findings revealed the H3K14ub-dependent SUV39H compartmentalization as a unified mechanism of pericentromeric heterochromatin formation, which is essential for proper euchromatin compartmentalization and transcriptional regulation.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"1 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145296185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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