Nature最新文献 - Book学术

My AI chatbot thinks my idea is fundable 我的人工智能聊天机器人认为我的想法是可行的

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-31 DOI: 10.1038/d41586-025-02190-w

引用次数: 0

How allergens make us cough and wheeze — by poking holes in airway cells 过敏原是如何通过在气道细胞上戳洞而使我们咳嗽和喘息的

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-31 DOI: 10.1038/d41586-025-02432-x

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Observation of elusive interaction between neutrinos and atomic nuclei 观测中微子和原子核之间难以捉摸的相互作用

IF 48.5 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/d41586-025-02134-4

Henry T. Wong

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Mouse lemur cell atlas informs primate genes, physiology and disease 鼠狐猴细胞图谱揭示了灵长类动物的基因、生理和疾病

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/s41586-025-09114-8

Camille Ezran, Shixuan Liu, Stephen Chang, Jingsi Ming, Lisbeth A. Guethlein, Michael F. Z. Wang, Roozbeh Dehghannasiri, Julia Olivieri, Hannah K. Frank, Alexander Tarashansky, Winston Koh, Qiuyu Jing, Olga Botvinnik, Jane Antony, Angela Oliveira Pisco, Jim Karkanias, Can Yang, James E. Ferrell, Scott D. Boyd, Peter Parham, Jonathan Z. Long, Bo Wang, Julia Salzman, Iwijn De Vlaminck, Angela Ruohao Wu, Stephen R. Quake, Mark A. Krasnow

{"title":"Mouse lemur cell atlas informs primate genes, physiology and disease","authors":"Camille Ezran, Shixuan Liu, Stephen Chang, Jingsi Ming, Lisbeth A. Guethlein, Michael F. Z. Wang, Roozbeh Dehghannasiri, Julia Olivieri, Hannah K. Frank, Alexander Tarashansky, Winston Koh, Qiuyu Jing, Olga Botvinnik, Jane Antony, Angela Oliveira Pisco, Jim Karkanias, Can Yang, James E. Ferrell, Scott D. Boyd, Peter Parham, Jonathan Z. Long, Bo Wang, Julia Salzman, Iwijn De Vlaminck, Angela Ruohao Wu, Stephen R. Quake, Mark A. Krasnow","doi":"10.1038/s41586-025-09114-8","DOIUrl":"https://doi.org/10.1038/s41586-025-09114-8","url":null,"abstract":"Mouse lemurs (Microcebus spp.) are an emerging primate model organism, but their genetics, cellular and molecular biology remain largely unexplored. In an accompanying paper1, we performed large-scale single-cell RNA sequencing of 27 organs from mouse lemurs. We identified more than 750 molecular cell types, characterized their transcriptomic profiles and provided insight into primate evolution of cell types. Here we use the generated atlas to characterize mouse lemur genes, physiology, disease and mutations. We uncover thousands of previously unidentified lemur genes and hundreds of thousands of new splice junctions including over 85,000 primate splice junctions missing in mice. We systematically explore the lemur immune system by comparing global expression profiles of key immune genes in health and disease, and by mapping immune cell development, trafficking and activation. We characterize primate-specific and lemur-specific physiology and disease, including molecular features of the immune program, lemur adipocytes and metastatic endometrial cancer that resembles the human malignancy. We present expression patterns of more than 400 primate genes missing in mice, many with similar expression patterns to humans and some implicated in human disease. Finally, we provide an experimental framework for reverse genetic analysis by identifying naturally occurring nonsense mutations in three primate immune genes missing in mice and by analysing their transcriptional phenotypes. This work establishes a foundation for molecular and genetic analyses of mouse lemurs and prioritizes primate genes, isoforms, physiology and disease for future study.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"26 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Retraction Note: Parkin and PINK1 mitigate STING-induced inflammation 注：Parkin和PINK1可减轻蜇伤引起的炎症

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/s41586-025-09346-8

Danielle A. Sliter, Jennifer Martinez, Ling Hao, Xi Chen, Nuo Sun, Tara D. Fischer, Jonathon L. Burman, Yan Li, Zhe Zhang, Derek P. Narendra, Huaibin Cai, Max Borsche, Christine Klein, Richard J. Youle

引用次数: 0

Things I miss about civilization 我对文明的怀念

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/d41586-025-02248-9

引用次数: 0

Programmable protein ligation on cell surfaces 细胞表面的可编程蛋白连接

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/s41586-025-09287-2

Christian Kofoed, Girum Erkalo, Nicholas E. S. Tay, Xuanjia Ye, Yutong Lin, Tom W. Muir

{"title":"Programmable protein ligation on cell surfaces","authors":"Christian Kofoed, Girum Erkalo, Nicholas E. S. Tay, Xuanjia Ye, Yutong Lin, Tom W. Muir","doi":"10.1038/s41586-025-09287-2","DOIUrl":"https://doi.org/10.1038/s41586-025-09287-2","url":null,"abstract":"The surface landscapes of cells differ as a function of cell type and are frequently altered in disease contexts1,2,3. Exploiting such differences is key to many therapeutic strategies and is the basis for developing diagnostic and basic-science tools. State-of-the-art strategies typically target single surface antigens, but each individual receptor rarely defines the specific cell type4,5. The development of programmable molecular systems that integrate multiple cell-surface features to convert on-target inputs to user-defined outputs is therefore highly desirable. Here we describe an autonomous decision-making device driven by proximity-gated protein trans-splicing that allows local generation of an active protein from two otherwise inactive polypeptide fragments. We show that this protein-actuator platform can perform convergent protein ligation on designated cell surfaces, allowing highly selective generation of active proteins, which can either remain physically associated with the cell surface on which they were manufactured or be released into the surrounding milieu. Because of its intrinsic modularity and tunability, we demonstrate that the technology is compatible with different types of input, targeting modality and functional output, allowing for the localized interrogation or manipulation of cellular systems.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"125 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flourishing chemosynthetic life at the greatest depths of hadal trenches 在海沟的最深处，繁盛的化学合成生命

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/s41586-025-09317-z

Xiaotong Peng, Mengran Du, Andrey Gebruk, Shuangquan Liu, Zhaoming Gao, Ronnie N. Glud, Peng Zhou, Ruoheng Wang, Ashley A. Rowden, Gennady M. Kamenev, Anastassya S. Maiorova, Dominic Papineau, Shun Chen, Jinwei Gao, Helu Liu, Yuan He, Inna L. Alalykina, Igor Yu. Dolmatov, Hanyu Zhang, Xuegong Li, Marina V. Malyutina, Shamik Dasgupta, Anastasiia A. Saulenko, Vladimir A. Shilov, Shuting Liu, Tongtong Xie, Yuangao Qu, Xikun Song, Haibin Zhang, Hao Liu, Weijia Zhang, Xiaoxia Huang, Hongzhou Xu, Wenjing Xu, Vladimir V. Mordukhovich, Andrey V. Adrianov

{"title":"Flourishing chemosynthetic life at the greatest depths of hadal trenches","authors":"Xiaotong Peng, Mengran Du, Andrey Gebruk, Shuangquan Liu, Zhaoming Gao, Ronnie N. Glud, Peng Zhou, Ruoheng Wang, Ashley A. Rowden, Gennady M. Kamenev, Anastassya S. Maiorova, Dominic Papineau, Shun Chen, Jinwei Gao, Helu Liu, Yuan He, Inna L. Alalykina, Igor Yu. Dolmatov, Hanyu Zhang, Xuegong Li, Marina V. Malyutina, Shamik Dasgupta, Anastasiia A. Saulenko, Vladimir A. Shilov, Shuting Liu, Tongtong Xie, Yuangao Qu, Xikun Song, Haibin Zhang, Hao Liu, Weijia Zhang, Xiaoxia Huang, Hongzhou Xu, Wenjing Xu, Vladimir V. Mordukhovich, Andrey V. Adrianov","doi":"10.1038/s41586-025-09317-z","DOIUrl":"https://doi.org/10.1038/s41586-025-09317-z","url":null,"abstract":"Hadal trenches, some of the Earth’s least explored and understood environments, have long been proposed to harbour chemosynthesis-based communities1,2. Despite increasing attention, actual documentation of such communities has been exceptionally rare3,4. Here we report the discovery of the deepest and the most extensive chemosynthesis-based communities known to exist on Earth during an expedition to the Kuril–Kamchatka Trench and the western Aleutian Trench using the manned submersible Fendouzhe. The communities dominated by siboglinid Polychaeta and Bivalvia span a distance of 2,500 km at depths from 5,800 m to 9,533 m. These communities are sustained by hydrogen sulfide-rich and methane-rich fluids that are transported along faults traversing deep sediment layers in trenches, where methane is produced microbially from deposited organic matter, as indicated by isotopic analysis. Given geological similarities with other hadal trenches, such chemosynthesis-based communities might be more widespread than previously anticipated. These findings challenge current models of life at extreme limits and carbon cycling in the deep ocean.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"37 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards more effective nature-based climate solutions in global forests 在全球森林中寻求更有效的基于自然的气候解决方案

IF 48.5 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/s41586-025-09116-6

William R. L. Anderegg, Libby Blanchard, Christa Anderson, Grayson Badgley, Danny Cullenward, Peng Gao, Michael L. Goulden, Barbara Haya, Jennifer A. Holm, Matthew D. Hurteau, Marysa Lague, Meng Liu, Kimberly A. Novick, James Randerson, Anna T. Trugman, Jonathan A. Wang, Christopher A. Williams, Chao Wu, Linqing Yang

{"title":"Towards more effective nature-based climate solutions in global forests","authors":"William R. L. Anderegg, Libby Blanchard, Christa Anderson, Grayson Badgley, Danny Cullenward, Peng Gao, Michael L. Goulden, Barbara Haya, Jennifer A. Holm, Matthew D. Hurteau, Marysa Lague, Meng Liu, Kimberly A. Novick, James Randerson, Anna T. Trugman, Jonathan A. Wang, Christopher A. Williams, Chao Wu, Linqing Yang","doi":"10.1038/s41586-025-09116-6","DOIUrl":"10.1038/s41586-025-09116-6","url":null,"abstract":"Terrestrial ecosystems could contribute to climate mitigation through nature-based climate solutions (NbCS), which aim to reduce ecosystem greenhouse gas emissions and/or increase ecosystem carbon storage. Forests have the largest potential for NbCS, aligned with broader sustainability benefits, but—unfortunately—a broad body of literature has revealed widespread problems in forest NbCS projects and protocols that undermine the climate mitigation of forest carbon credits and hamper efforts to reach global net zero. Therefore, there is a need to bring better science and policy to improve NbCS climate mitigation outcomes going forward. Here we synthesize challenges to crediting forest NbCS and offer guidance and key next steps to make improvements in the implementation of these strategies immediately and in the near-term. We structure our Perspective around four key components of rigorous forest NbCS, illuminating key science and policy considerations and providing solutions to improve rigour. Finally, we outline a ‘contribution approach’ to support rigorous forest NbCS that is an alternative funding mechanism that disallows compensation or offsetting claims. A strategy to improve the implementation of nature-based climate solutions in global forests for climate mitigation is described, comprising four key components to highlight notable science and policy considerations and providing solutions to improve rigour.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"643 8074","pages":"1214-1222"},"PeriodicalIF":48.5,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144737110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily briefing: What does quantum mechanics mean anyway? 每日简报：量子力学到底是什么意思？

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-07-30 DOI: 10.1038/d41586-025-02444-7

引用次数: 0