IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01396-2

引用次数: 0

Daily briefing: A supersingular elliptic curve brought to life — the month’s best science images 每日简报：一个超奇异椭圆曲线被赋予生命——本月最佳科学图片

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01400-9

引用次数: 0

Powerful protein editors offer new ways of probing living cells 强大的蛋白质编辑器提供了探测活细胞的新方法

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01358-8

引用次数: 0

Whale earwax, fungal fertilizer and chocolate emissions: exhibition explores biodiversity research 鲸鱼耳垢、真菌肥料和巧克力排放：展览探索生物多样性研究

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01351-1

引用次数: 0

Revealed: the unusual mathematics that gives rose petals their shape 揭秘：玫瑰花瓣形状的不寻常数学

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01394-4

引用次数: 0

Storm of seizures in a baby’s brain calms after trial therapy 经过试验治疗后，婴儿大脑的癫痫发作平静下来

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-05-01 DOI: 10.1038/d41586-025-01322-6

引用次数: 0

A DNA-gated molecular guard controls bacterial Hailong anti-phage defence dna门控分子守卫控制细菌海龙抗噬菌体防御

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-04-30 DOI: 10.1038/s41586-025-09058-z

Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina Del Marmol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch

{"title":"A DNA-gated molecular guard controls bacterial Hailong anti-phage defence","authors":"Joel M. J. Tan, Sarah Melamed, Joshua C. Cofsky, Deepsing Syangtan, Samuel J. Hobbs, Josefina Del Marmol, Marco Jost, Andrew C. Kruse, Rotem Sorek, Philip J. Kranzusch","doi":"10.1038/s41586-025-09058-z","DOIUrl":"https://doi.org/10.1038/s41586-025-09058-z","url":null,"abstract":"Animal and bacterial cells use nucleotidyltransferase (NTase) enzymes to respond to viral infection and control major forms of immune signaling including cGAS-STING innate immunity and CBASS anti-phage defence1-4. Here we discover a family of bacterial defence systems, which we name Hailong, that use NTase enzymes to constitutively synthesize DNA signals and guard against phage infection. Hailong protein B (HalB) is an NTase that converts deoxy-ATP into single-stranded DNA oligomers. A series of X-ray crystal structures define a stepwise mechanism of HalB DNA synthesis initiated by a C-terminal tyrosine residue that enables de novo enzymatic priming. We show that HalB DNA signals bind to and repress activation of a partnering Hailong protein A (HalA) effector complex. A 2.0 Å cryo-EM structure of the HalA–DNA complex reveals a membrane protein with a conserved ion channel domain and a unique crown domain that binds the DNA signal and gates activation. Analyzing Hailong defence in vivo, we demonstrate that viral DNA exonucleases required for phage replication trigger release of the primed HalA complex and induce protective host cell growth arrest. Our results explain how inhibitory nucleotide immune signals can serve as molecular guards against phage infection and expand the mechanisms NTase enzymes use to control antiviral immunity.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"11 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TIR domains produce histidine-ADPR as an immune signal in bacteria TIR结构域在细菌中产生组氨酸- adpr作为免疫信号

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-04-30 DOI: 10.1038/s41586-025-08930-2

Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arunas Silanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda, Audrone Ruksenaite, Mindaugas Zaremba, Ilya Osterman, Gil Amitai, Philip J. Kranzusch, Rotem Sorek, Giedre Tamulaitiene

{"title":"TIR domains produce histidine-ADPR as an immune signal in bacteria","authors":"Dziugas Sabonis, Carmel Avraham, Renee B. Chang, Allen Lu, Ehud Herbst, Arunas Silanskas, Deividas Vilutis, Azita Leavitt, Erez Yirmiya, Hunter C. Toyoda, Audrone Ruksenaite, Mindaugas Zaremba, Ilya Osterman, Gil Amitai, Philip J. Kranzusch, Rotem Sorek, Giedre Tamulaitiene","doi":"10.1038/s41586-025-08930-2","DOIUrl":"https://doi.org/10.1038/s41586-025-08930-2","url":null,"abstract":"Toll/interleukin-1 receptor (TIR) domains are central components of pattern recognition immune proteins across all domains of life1,2. In bacteria and plants, TIR-domain proteins recognize pathogen invasion and then produce immune signalling molecules exclusively comprising nucleotide moieties2,3,4,5. Here we show that the TIR-domain protein of the type II Thoeris defence system in bacteria produces a unique signalling molecule comprising the amino acid histidine conjugated to ADP-ribose (His-ADPR). His-ADPR is generated in response to phage infection and activates the cognate Thoeris effector by binding a Macro domain located at the C terminus of the effector protein. By determining the crystal structure of a ligand-bound Macro domain, we describe the structural basis for His-ADPR and its recognition and show its role by biochemical and mutational analyses. Our analyses furthermore reveal a family of phage proteins that bind and sequester His-ADPR signalling molecules, enabling phages to evade TIR-mediated immunity. These data demonstrate diversity in bacterial TIR signalling and reveal a new class of TIR-derived immune signalling molecules that combine nucleotide and amino acid moieties.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"104 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143893377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammatory bowel disease has stages of epidemiology that can be tracked across global regions 炎症性肠病有不同的流行病学阶段，可以在全球各地追踪

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-04-30 DOI: 10.1038/d41586-025-01301-x

引用次数: 0

The end of AIDS is in sight: don’t abandon PEPFAR now 艾滋病的终结在望：现在不要放弃总统防治艾滋病紧急救援计划

IF 50.5 1区综合性期刊

Nature Pub Date : 2025-04-30 DOI: 10.1038/d41586-025-01308-4

引用次数: 0

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