NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00437-0
{"title":"What are the best AI tools for research? Nature’s guide","authors":"","doi":"10.1038/d41586-025-00437-0","DOIUrl":"https://doi.org/10.1038/d41586-025-00437-0","url":null,"abstract":"There are many large language models to choose from; some excel at coding, whereas others are better for synthesizing information.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"56 6 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00461-0
Rachel Brazil
{"title":"Here’s how to bag a hefty research prize to turbocharge innovation","authors":"Rachel Brazil","doi":"10.1038/d41586-025-00461-0","DOIUrl":"10.1038/d41586-025-00461-0","url":null,"abstract":"‘Challenge’ prizes are growing in popularity, but stimulating creativity takes more than financial incentives. ‘Challenge’ prizes are growing in popularity, but stimulating creativity takes more than financial incentives.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"638 8051","pages":"845-847"},"PeriodicalIF":50.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/d41586-025-00461-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00459-8
Linsey C. Marr
{"title":"Researchers overlooked airborne diseases for centuries — then COVID-19 changed everything","authors":"Linsey C. Marr","doi":"10.1038/d41586-025-00459-8","DOIUrl":"10.1038/d41586-025-00459-8","url":null,"abstract":"A fascinating exploration of microbes that can travel through the air reveals how the pandemic marked a turning point for a crucial research field. A fascinating exploration of microbes that can travel through the air reveals how the pandemic marked a turning point for a crucial research field.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"638 8051","pages":"607-608"},"PeriodicalIF":50.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/d41586-025-00459-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00516-2
{"title":"Daily briefing: The ‘dark side’ of the Asilomar conference","authors":"","doi":"10.1038/d41586-025-00516-2","DOIUrl":"https://doi.org/10.1038/d41586-025-00516-2","url":null,"abstract":"A new theory on how intelligent life evolved on Earth. Plus, the ‘dark side’ of the Asilomar conference on recombinant DNA.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"30 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ambient-pressure superconductivity onset above 40 K in (La,Pr)3Ni2O7 films","authors":"Guangdi Zhou, Wei Lv, Heng Wang, Zihao Nie, Yaqi Chen, Yueying Li, Haoliang Huang, Weiqiang Chen, Yujie Sun, Qi-Kun Xue, Zhuoyu Chen","doi":"10.1038/s41586-025-08755-z","DOIUrl":"https://doi.org/10.1038/s41586-025-08755-z","url":null,"abstract":"<p>The discovery of bilayer nickelate superconductors under high pressure has opened a new chapter in high-transition temperature (high-<i>T</i><sub>C</sub>) superconductivity<sup>1-8</sup>. However, the high-pressure condition and presence of impurity phases have hindered comprehensive investigations into their superconducting properties and potential applications. Here, we report ambient-pressure superconductivity onset above the McMillan limit (40 K) in bilayer nickelate epitaxial thin films. Three-unit-cell (3UC) thick La<sub>2.85</sub>Pr<sub>0.15</sub>Ni<sub>2</sub>O<sub>7</sub> pure-phase single-crystal films are grown using the gigantic-oxidative atomic-layer-by-layer epitaxy (GOALL-Epitaxy) on SrLaAlO<sub>4</sub> substrates<sup>9</sup>. Resistivity measurements and magnetic-field responses indicate onset <i>T</i><sub>C</sub> = 45 K. The transition to zero resistance exhibits characteristics consistent with a Berezinskii–Kosterlitz–Thouless (BKT)-like behavior, with <i>T</i><sub>BKT</sub> = 9 K. Meissner diamagnetic effect is observed at <i>T</i><sub>M</sub> = 8 K via a mutual inductance setup, in agreement with the BKT-like transition. In-plane and out-of-plane critical magnetic fields exhibit anisotropy. Scanning transmission electron microscopy (STEM) images and X-ray reciprocal space mappings (RSMs) reveal that the bilayer nickelate films adopt a tetragonal phase under ~2% coherent epitaxial compressive strain in the NiO<sub>2</sub> planes relative to the bulk. Our findings pave the way for comprehensive investigations of nickelate superconductors under ambient pressure conditions and for exploring superconductivity at higher transition temperature through strain engineering in heterostructures.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"10 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/s41586-025-08763-z
Pablo Alcón, Artur P. Kaczmarczyk, Korak Kumar Ray, Themistoklis Liolios, Guillaume Guilbaud, Tamara Sijacki, Yichao Shen, Stephen H. McLaughlin, Julian E. Sale, Puck Knipscheer, David S. Rueda, Lori A. Passmore
{"title":"Author Correction: FANCD2–FANCI surveys DNA and recognizes double- to single-stranded junctions","authors":"Pablo Alcón, Artur P. Kaczmarczyk, Korak Kumar Ray, Themistoklis Liolios, Guillaume Guilbaud, Tamara Sijacki, Yichao Shen, Stephen H. McLaughlin, Julian E. Sale, Puck Knipscheer, David S. Rueda, Lori A. Passmore","doi":"10.1038/s41586-025-08763-z","DOIUrl":"https://doi.org/10.1038/s41586-025-08763-z","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-024-07770-w Published online 31 July 2024</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"6 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00463-y
Esme Hedley
{"title":"‘Talking won’t save the planet’: uniting efforts to save Panama’s parks","authors":"Esme Hedley","doi":"10.1038/d41586-025-00463-y","DOIUrl":"10.1038/d41586-025-00463-y","url":null,"abstract":"Juan Carlos Navarro shares his hopes and frustrations as he works to protect his country’s biodiversity and fight climate change. Juan Carlos Navarro shares his hopes and frustrations as he works to protect his country’s biodiversity and fight climate change.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"638 8051","pages":"852-852"},"PeriodicalIF":50.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/d41586-025-00463-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/s41586-025-08735-3
Vera Thiel, Simon Renders, Jasper Panten, Nicolas Dross, Katharina Bauer, Daniel Azorin, Vanessa Henriques, Vanessa Vogel, Corinna Klein, Aino-Maija Leppä, Isabel Barriuso Ortega, Jonas Schwickert, Iordanis Ourailidis, Julian Mochayedi, Jan-Philipp Mallm, Carsten Müller-Tidow, Hannah Monyer, John Neoptolemos, Thilo Hackert, Oliver Stegle, Duncan T. Odom, Rienk Offringa, Albrecht Stenzinger, Frank Winkler, Martin Sprick, Andreas Trumpp
{"title":"Characterization of single neurons reprogrammed by pancreatic cancer","authors":"Vera Thiel, Simon Renders, Jasper Panten, Nicolas Dross, Katharina Bauer, Daniel Azorin, Vanessa Henriques, Vanessa Vogel, Corinna Klein, Aino-Maija Leppä, Isabel Barriuso Ortega, Jonas Schwickert, Iordanis Ourailidis, Julian Mochayedi, Jan-Philipp Mallm, Carsten Müller-Tidow, Hannah Monyer, John Neoptolemos, Thilo Hackert, Oliver Stegle, Duncan T. Odom, Rienk Offringa, Albrecht Stenzinger, Frank Winkler, Martin Sprick, Andreas Trumpp","doi":"10.1038/s41586-025-08735-3","DOIUrl":"https://doi.org/10.1038/s41586-025-08735-3","url":null,"abstract":"<p>The peripheral nervous system (PNS) orchestrates organ function in health and disease. Most cancers including pancreatic ductal adenocarcinoma (PDAC) are infiltrated by PNS neurons, contributing to the complex tumor microenvironment (TME)<sup>1,2</sup>. However, neuronal cell bodies reside in various PNS ganglia, far from the tumor mass. Thus, cancer or healthy organ-innervating neurons elude current tissue sequencing datasets. To molecularly characterize pancreas- and PDAC-innervating neurons at single cell resolution, we developed “Trace-n-seq”. This method employs retrograde tracing of axons from tissues to their respective ganglia followed by single-cell isolation and transcriptomic analysis. By characterizing >5.000 individual sympathetic and sensory neurons with about 4.000 innervating PDAC or healthy pancreas we reveal novel neuronal cell types and unique molecular networks distinct to pancreas, pancreatitis, PDAC, or melanoma metastasis. We integrate single-cell datasets of innervating neurons and the TME to establish a neuro-cancer-microenvironment interactome, delineate cancer-driven neuronal reprogramming and generate a pancreatic cancer-nerve signature. Pharmacological denervation induces a proinflammatory TME and increases immune-checkpoint inhibitor effectiveness. Nab-Paclitaxel causes intra-tumor neuropathy which attenuated PDAC growth and in combination with sympathetic denervation results in synergistic tumor regression. Our multi-dimensional data reveal new insights into the networks and functions of PDAC-innervating neurons, supporting inclusion of denervation in future therapies.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"15 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00457-w
Matthew Cobb
{"title":"Money and murder: the dark side of the Asilomar meeting on recombinant DNA","authors":"Matthew Cobb","doi":"10.1038/d41586-025-00457-w","DOIUrl":"10.1038/d41586-025-00457-w","url":null,"abstract":"The famed 1975 conference about a controversial genetic technology is feted as an example of how scientific self-regulation works. But more significant is what wasn’t discussed. The famed 1975 conference about a controversial genetic technology is feted as an example of how scientific self-regulation works. But more significant is what wasn’t discussed.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"638 8051","pages":"603-606"},"PeriodicalIF":50.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/d41586-025-00457-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143427093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2025-02-17DOI: 10.1038/d41586-025-00507-3
{"title":"Woman in cancer remission for record 19 years after CAR-T immune treatment","authors":"","doi":"10.1038/d41586-025-00507-3","DOIUrl":"https://doi.org/10.1038/d41586-025-00507-3","url":null,"abstract":"CAR-T-cell therapy treated a girl with a rare childhood cancer, raising hopes for future recipients of the approach.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"80 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143435277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
