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The other climate crisis

IF 50.5 1区综合性期刊

Nature Pub Date : 2025-03-26 DOI: 10.1038/s41586-025-08680-1

Tiffany A. Shaw, Bjorn Stevens

{"title":"The other climate crisis","authors":"Tiffany A. Shaw, Bjorn Stevens","doi":"10.1038/s41586-025-08680-1","DOIUrl":"10.1038/s41586-025-08680-1","url":null,"abstract":"As Earth warms, regional climate signals are accumulating. Some signals, for example, land warming more than the ocean and the Arctic warming the most, were expected and successfully predicted. Underlying this success was the application of physical laws under the assumption that large and small spatial scales are well separated. This established what we call the standard approach, climate science’s dominant paradigm. With additional warming, however, discrepancies between real-world signals and expectations based on this standard approach are piling up, especially at regional scales. At the same time, disruptive computational approaches are advancing new paradigms. Philosophers of science characterize situations where accumulating discrepancies (anomalies) and disruptions lead to a loss of confidence in the dominant paradigm as a ‘crisis’. Here we articulate what we consider to be the dominant paradigm, or standard approach, and the discrepancies and disruptions that have emerged in recent years. The policy implications of a purported crisis are discussed, as well as paths forward, crisis or no crisis. These paths include using signals to test assumptions and processes driving a warming Earth for the first time, developing testable hypotheses, and revitalizing conceptual thinking by filling gaps across climate-system components and spatial scales. The standard approach of climate science is showing signs of a crisis owing to the emergence of discrepancies and disruptions in recent years; this Perspective discusses the policy implications and the paths forward.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"639 8056","pages":"877-887"},"PeriodicalIF":50.5,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Daily briefing: Why RNA hasn’t yet had its ‘AlphaFold’ moment

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-03-26 DOI: 10.1038/d41586-025-00974-8

引用次数: 0

MFSD6 is an entry receptor for enterovirus D68

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-03-25 DOI: 10.1038/s41586-025-08908-0

Lauren Varanese, Lily Xu, Christine E. Peters, Grigore Pintilie, David S. Roberts, Suyash Raj, Mengying Liu, Yaw Shin Ooi, Jonathan Diep, Wenjie Qiao, Christopher M. Richards, Jeremy Callaway, Carolyn R. Bertozzi, Sabrina Jabs, Erik de Vries, Frank J. M. van Kuppeveld, Claude M. Nagamine, Wah Chiu, Jan E. Carette

{"title":"MFSD6 is an entry receptor for enterovirus D68","authors":"Lauren Varanese, Lily Xu, Christine E. Peters, Grigore Pintilie, David S. Roberts, Suyash Raj, Mengying Liu, Yaw Shin Ooi, Jonathan Diep, Wenjie Qiao, Christopher M. Richards, Jeremy Callaway, Carolyn R. Bertozzi, Sabrina Jabs, Erik de Vries, Frank J. M. van Kuppeveld, Claude M. Nagamine, Wah Chiu, Jan E. Carette","doi":"10.1038/s41586-025-08908-0","DOIUrl":"https://doi.org/10.1038/s41586-025-08908-0","url":null,"abstract":"With the near eradication of poliovirus due to global vaccination campaigns, attention has shifted to other enteroviruses that can cause polio-like paralysis syndrome (now termed acute flaccid myelitis (AFM))1–3. In particular, enterovirus D68 (EV-D68) is believed to be the main driver of epidemic outbreaks of AFM in recent years4, yet not much is known about EV-D68 host interactions. EV-D68 is a respiratory virus5 but, in rare cases, can spread to the central nervous system to cause severe neuropathogenesis. Here, we used genome-scale CRISPR screens to identify the poorly characterized multipass membrane transporter MFSD6 as a host entry factor for EV-D68. Knockout of MFSD6 expression abrogated EV-D68 infection in cell lines and primary cells corresponding to respiratory and neural cells. MFSD6 localized to the plasma membrane and was required for viral entry into host cells. MFSD6 bound directly to EV-D68 particles via its third extracellular loop (L3). We determined the cryo-EM structure of EV-D68 in complex with L3 at 2.1 Å resolution, revealing the interaction interface. A decoy receptor, engineered by fusing MFSD6(L3) to Fc, blocked EV-D68 infection of human primary lung epithelial cells, and provided near complete protection in a lethal mouse model of EV-D68 infection. Collectively, our results reveal MFSD6 as an entry receptor for EV-D68, and support targeting MFSD6 as a potential mechanism to combat infections by this emerging pathogen with pandemic potential.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"57 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143703153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ancient shackles testify to brutality of Egypt’s gold mines

IF 64.8 1区综合性期刊

Nature Pub Date : 2025-03-25 DOI: 10.1038/d41586-025-00878-7

引用次数: 0

Lessons from Portugal on effects of cutting research funding

IF 50.5 1区综合性期刊

Nature Pub Date : 2025-03-25 DOI: 10.1038/d41586-025-00928-0

Marc Veldhoen, João T. Barata, Luisa M. Figueiredo, Claus M. Azzalin