Nature最新文献

{"title":"Episodic and associative memory from spatial scaffolds in the hippocampus","authors":"Sarthak Chandra, Sugandha Sharma, Rishidev Chaudhuri, Ila Fiete","doi":"10.1038/s41586-024-08392-y","DOIUrl":"https://doi.org/10.1038/s41586-024-08392-y","url":null,"abstract":"<p>Hippocampal circuits in the brain enable two distinct cognitive functions: the construction of spatial maps for navigation, and the storage of sequential episodic memories^1,2,3,4,5. Although there have been advances in modelling spatial representations in the hippocampus^6,7,8,9,10, we lack good models of its role in episodic memory. Here we present a neocortical–entorhinal–hippocampal network model that implements a high-capacity general associative memory, spatial memory and episodic memory. By factoring content storage from the dynamics of generating error-correcting stable states, the circuit (which we call vector hippocampal scaffolded heteroassociative memory (Vector-HaSH)) avoids the memory cliff of prior memory models^11,12, and instead exhibits a graceful trade-off between number of stored items and recall detail. A pre-structured internal scaffold based on grid cell states is essential for constructing even non-spatial episodic memory: it enables high-capacity sequence memorization by abstracting the chaining problem into one of learning low-dimensional transitions. Vector-HaSH reproduces several hippocampal experiments on spatial mapping and context-based representations, and provides a circuit model of the ‘memory palaces’ used by memory athletes¹³. Thus, this work provides a unified understanding of the spatial mapping and associative and episodic memory roles of the hippocampus.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"37 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer","authors":"Masataka Amisaki, Abderezak Zebboudj, Hiroshi Yano, Siqi Linsey Zhang, George Payne, Adrienne Kaya Chandra, Rebecca Yu, Pablo Guasp, Zachary M. Sethna, Akihiro Ohmoto, Luis A. Rojas, Charlotte Cheng, Theresa Waters, Alexander Solovyov, Stephen Martis, Ashley S. Doane, Charlotte Reiche, Emmanuel M. Bruno, Martina Milighetti, Kevin Soares, Zagaa Odgerel, John Alec Moral, Julia N. Zhao, Mithat Gönen, Rui Gardner, Alexei V. Tumanov, Abdul G. Khan, Olivia Vergnolle, Elisabeth K. Nyakatura, Ivo C. Lorenz, Manuel Baca, Erin Patterson, Benjamin Greenbaum, David Artis, Taha Merghoub, Vinod P. Balachandran","doi":"10.1038/s41586-024-08426-5","DOIUrl":"https://doi.org/10.1038/s41586-024-08426-5","url":null,"abstract":"<p>Tertiary lymphoid structures (TLSs) are de novo ectopic lymphoid aggregates that regulate immunity in chronically inflamed tissues, including tumours. Although TLSs form due to inflammation-triggered activation of the lymphotoxin (LT)–LTβ receptor (LTβR) pathway¹, the inflammatory signals and cells that induce TLSs remain incompletely identified. Here we show that interleukin-33 (IL-33), the alarmin released by inflamed tissues², induces TLSs. In mice, <i>Il33</i> deficiency severely attenuates inflammation- and LTβR-activation-induced TLSs in models of colitis and pancreatic ductal adenocarcinoma (PDAC). In PDAC, the alarmin domain of IL-33 activates group 2 innate lymphoid cells (ILC2s) expressing LT that engage putative LTβR⁺ myeloid organizer cells to initiate tertiary lymphoneogenesis. Notably, lymphoneogenic ILC2s migrate to PDACs from the gut, can be mobilized to PDACs in different tissues and are modulated by gut microbiota. Furthermore, we detect putative lymphoneogenic ILC2s and IL-33-expressing cells within TLSs in human PDAC that correlate with improved prognosis. To harness this lymphoneogenic pathway for immunotherapy, we engineer a recombinant human IL-33 protein that expands intratumoural lymphoneogenic ILC2s and TLSs and demonstrates enhanced anti-tumour activity in PDAC mice. In summary, we identify the molecules and cells of a druggable pathway that induces inflammation-triggered TLSs. More broadly, we reveal a lymphoneogenic function for alarmins and ILC2s.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"75 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continental influx and pervasive matrilocality in Iron Age Britain","authors":"Lara M. Cassidy, Miles Russell, Martin Smith, Gabrielle Delbarre, Paul Cheetham, Harry Manley, Valeria Mattiangeli, Emily M. Breslin, Iseult Jackson, Maeve McCann, Harry Little, Ciarán G. O’Connor, Beth Heaslip, Daniel Lawson, Phillip Endicott, Daniel G. Bradley","doi":"10.1038/s41586-024-08409-6","DOIUrl":"https://doi.org/10.1038/s41586-024-08409-6","url":null,"abstract":"<p>Roman writers found the relative empowerment of Celtic women remarkable¹. In southern Britain, the Late Iron Age Durotriges tribe often buried women with substantial grave goods². Here we analyse 57 ancient genomes from Durotrigian burial sites and find an extended kin group centred around a single maternal lineage, with unrelated (presumably inward migrating) burials being predominantly male. Such a matrilocal pattern is undescribed in European prehistory, but when we compare mitochondrial haplotype variation among European archaeological sites spanning six millennia, British Iron Age cemeteries stand out as having marked reductions in diversity driven by the presence of dominant matrilines. Patterns of haplotype sharing reveal that British Iron Age populations form fine-grained geographical clusters with southern links extending across the channel to the continent. Indeed, whereas most of Britain shows majority genomic continuity from the Early Bronze Age to the Iron Age, this is markedly reduced in a southern coastal core region with persistent cross-channel cultural exchange³. This southern core has evidence of population influx in the Middle Bronze Age but also during the Iron Age. This is asynchronous with the rest of the island and points towards a staged, geographically granular absorption of continental influence, possibly including the acquisition of Celtic languages.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"14 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Daily briefing: New obesity definition sidelines BMI to focus on health","authors":"","doi":"10.1038/d41586-025-00147-7","DOIUrl":"https://doi.org/10.1038/d41586-025-00147-7","url":null,"abstract":"Researchers offer a more nuanced definition of obesity. Plus, two private Moon missions launch at the same time.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"7 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massively parallel characterization of transcriptional regulatory elements","authors":"Vikram Agarwal, Fumitaka Inoue, Max Schubach, Dmitry Penzar, Beth K. Martin, Pyaree Mohan Dash, Pia Keukeleire, Zicong Zhang, Ajuni Sohota, Jingjing Zhao, Ilias Georgakopoulos-Soares, William S. Noble, Galip Gürkan Yardımcı, Ivan V. Kulakovskiy, Martin Kircher, Jay Shendure, Nadav Ahituv","doi":"10.1038/s41586-024-08430-9","DOIUrl":"https://doi.org/10.1038/s41586-024-08430-9","url":null,"abstract":"<p>The human genome contains millions of candidate <i>cis</i>-regulatory elements (cCREs) with cell-type-specific activities that shape both health and many disease states¹. However, we lack a functional understanding of the sequence features that control the activity and cell-type-specific features of these cCREs. Here we used lentivirus-based massively parallel reporter assays (lentiMPRAs) to test the regulatory activity of more than 680,000 sequences, representing an extensive set of annotated cCREs among three cell types (HepG2, K562 and WTC11), and found that 41.7% of these sequences were active. By testing sequences in both orientations, we find promoters to have strand-orientation biases and their 200-nucleotide cores to function as non-cell-type-specific ‘on switches’ that provide similar expression levels to their associated gene. By contrast, enhancers have weaker orientation biases, but increased tissue-specific characteristics. Utilizing our lentiMPRA data, we develop sequence-based models to predict cCRE function and variant effects with high accuracy, delineate regulatory motifs and model their combinatorial effects. Testing a lentiMPRA library encompassing 60,000 cCREs in all three cell types further identified factors that determine cell-type specificity. Collectively, our work provides an extensive catalogue of functional CREs in three widely used cell lines and showcases how large-scale functional measurements can be used to dissect regulatory grammar.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"17 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methane emissions from the Nord Stream subsea pipeline leaks","authors":"Stephen J. Harris, Stefan Schwietzke, James L. France, Nataly Velandia Salinas, Tania Meixus Fernandez, Cynthia Randles, Luis Guanter, Itziar Irakulis-Loitxate, Andreea Calcan, Ilse Aben, Katarina Abrahamsson, Paul Balcombe, Antoine Berchet, Louise C. Biddle, Henry C. Bittig, Christian Böttcher, Timo Bouvard, Göran Broström, Valentin Bruch, Massimo Cassiani, Martyn P. Chipperfield, Philippe Ciais, Ellen Damm, Enrico Dammers, Hugo Denier van der Gon, Matthieu Dogniaux, Emily Dowd, François Dupouy, Sabine Eckhardt, Nikolaos Evangeliou, Wuhu Feng, Mengwei Jia, Fei Jiang, Andrea K. Kaiser-Weiss, Ines Kamoun, Brian J. Kerridge, Astrid Lampert, José Lana, Fei Li, Joannes D. Maasakkers, Jean-Philippe W. Maclean, Buhalqem Mamtimin, Julia Marshall, Gédéon Mauger, Anouar Mekkas, Christian Mielke, Martin Mohrmann, David P. Moore, Riccardo Nanni, Falk Pätzold, Isabelle Pison, Ignacio Pisso, Stephen M. Platt, Raphaël Préa, Bastien Y. Queste, Michel Ramonet, Gregor Rehder, John J. Remedios, Friedemann Reum, Anke Roiger, Norbert Schmidbauer, Richard Siddans, Anusha Sunkisala, Rona L. Thompson, Daniel J. Varon, Lucy J. Ventress, Chris Wilson, Yuzhong Zhang","doi":"10.1038/s41586-024-08396-8","DOIUrl":"https://doi.org/10.1038/s41586-024-08396-8","url":null,"abstract":"<p>The amount of methane released to the atmosphere from the Nord Stream subsea pipeline leaks remains uncertain, as reflected in a wide range of estimates^{1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18}. A lack of information regarding the temporal variation in atmospheric emissions has made it challenging to reconcile pipeline volumetric (bottom-up) estimates^{1,2,3,4,5,6,7,8} with measurement-based (top-down) estimates^{8,9,10,11,12,13,14,15,16,17,18}. Here we simulate pipeline rupture emission rates and integrate these with methane dissolution and sea-surface outgassing estimates^9,10 to model the evolution of atmospheric emissions from the leaks. We verify our modelled atmospheric emissions by comparing them with top-down point-in-time emission-rate estimates and cumulative emission estimates derived from airborne¹¹, satellite^8,12,13,14 and tall tower data. We obtain consistency between our modelled atmospheric emissions and top-down estimates and find that 465 ± 20 thousand metric tons of methane were emitted to the atmosphere. Although, to our knowledge, this represents the largest recorded amount of methane released from a single transient event, it is equivalent to 0.1% of anthropogenic methane emissions for 2022. The impact of the leaks on the global atmospheric methane budget brings into focus the numerous other anthropogenic methane sources that require mitigation globally. Our analysis demonstrates that diverse, complementary measurement approaches are needed to quantify methane emissions in support of the Global Methane Pledge¹⁹.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"29 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elemental cryo-imaging reveals SOS1-dependent vacuolar sodium accumulation","authors":"Priya Ramakrishna, Francisco M. Gámez-Arjona, Etienne Bellani, Cristina Martin-Olmos, Stéphane Escrig, Damien De Bellis, Anna De Luca, José M. Pardo, Francisco J. Quintero, Christel Genoud, Clara Sánchez-Rodriguez, Niko Geldner, Anders Meibom","doi":"10.1038/s41586-024-08403-y","DOIUrl":"https://doi.org/10.1038/s41586-024-08403-y","url":null,"abstract":"<p>Increasing soil salinity causes significant crop losses globally; therefore, understanding plant responses to salt (sodium) stress is of high importance. Plants avoid sodium toxicity through subcellular compartmentation by intricate processes involving a high level of elemental interdependence. Current technologies to visualize sodium, in particular, together with other elements, are either indirect or lack in resolution. Here we used the newly developed cryo nanoscale secondary ion mass spectrometry ion microprobe¹, which allows high-resolution elemental imaging of cryo-preserved samples and reveals the subcellular distributions of key macronutrients and micronutrients in root meristem cells of <i>Arabidopsis</i> and rice. We found an unexpected, concentration-dependent change in sodium distribution, switching from sodium accumulation in the cell walls at low external sodium concentrations to vacuolar accumulation at stressful concentrations. We conclude that, in root meristems, a key function of the NHX family sodium/proton antiporter SALT OVERLY SENSITIVE 1 (also known as Na⁺/H⁺ exchanger 7; SOS1/NHX7) is to sequester sodium into vacuoles, rather than extrusion of sodium into the extracellular space. This is corroborated by the use of new genomic, complementing fluorescently tagged SOS1 variants. We show that, in addition to the plasma membrane, SOS1 strongly accumulates at late endosome/prevacuoles as well as vacuoles, supporting a role of SOS1 in vacuolar sodium sequestration.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"42 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Illuminating the multidimensional contributions of small-scale fisheries","authors":"Xavier Basurto,&nbsp;Nicolas L. Gutierrez,&nbsp;Nicole Franz,&nbsp;Maria del Mar Mancha-Cisneros,&nbsp;Giulia Gorelli,&nbsp;Alba Aguión,&nbsp;Simon Funge-Smith,&nbsp;Sarah Harper,&nbsp;Dave J. Mills,&nbsp;Gianluigi Nico,&nbsp;Alex Tilley,&nbsp;Stefania Vannuccini,&nbsp;John Virdin,&nbsp;Lena Westlund,&nbsp;Edward H. Allison,&nbsp;Christopher M. Anderson,&nbsp;Andrew Baio,&nbsp;Joshua Cinner,&nbsp;Michael Fabinyi,&nbsp;Christina C. Hicks,&nbsp;Jeppe Kolding,&nbsp;Michael C. Melnychuk,&nbsp;Daniel Ovando,&nbsp;Ana M. Parma,&nbsp;James P. W. Robinson,&nbsp;Shakuntala H. Thilsted","doi":"10.1038/s41586-024-08448-z","DOIUrl":"10.1038/s41586-024-08448-z","url":null,"abstract":"Sustainable development aspires to “leave no one behind”1. Even so, limited attention has been paid to small-scale fisheries (SSF) and their importance in eradicating poverty, hunger and malnutrition. Through a collaborative and multidimensional data-driven approach, we have estimated that SSF provide at least 40% (37.3 million tonnes) of global fisheries catches and 2.3 billion people with, on average, 20% of their dietary intake across six key micronutrients essential for human health. Globally, the livelihood of 1 in every 12 people, nearly half of them women, depends at least partly on small-scale fishing, in total generating 44% (US$77.2 billion) of the economic value of all fisheries landed. Regionally, Asian SSF provide fish, support livelihoods and supply nutrition to the largest number of people. Relative to the total capture of the fisheries sector (comprising large-scale and small-scale fisheries), across all regions, African SSF supply the most catch and nutrition, and SSF in Oceania improve the most livelihoods. Maintaining and increasing these multidimensional SSF contributions to sustainable development requires targeted and effective actions, especially increasing the engagement of fisherfolk in shared management and governance. Without management and governance focused on the multidimensional contributions of SSF, the marginalization of millions of fishers and fishworkers will worsen. A study aimed at revealing the role of small-scale fisheries in sustainable development shows they provide at least 40% of the global fishing catch and affect the livelihoods of 1 in 12 people in the world, among other important contributions.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"637 8047","pages":"875-884"},"PeriodicalIF":50.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41586-024-08448-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-lived entanglement of molecules in magic-wavelength optical tweezers","authors":"Daniel K. Ruttley,&nbsp;Tom R. Hepworth,&nbsp;Alexander Guttridge,&nbsp;Simon L. Cornish","doi":"10.1038/s41586-024-08365-1","DOIUrl":"10.1038/s41586-024-08365-1","url":null,"abstract":"Realizing quantum control and entanglement of particles is crucial for advancing both quantum technologies and fundamental science. Substantial developments in this domain have been achieved in a variety of systems1–5. In this context, ultracold polar molecules offer new and unique opportunities because of their more complex internal structure associated with vibration and rotation, coupled with the existence of long-range interactions6,7. However, the same properties make molecules highly sensitive to their environment8–10, affecting their coherence and utility in some applications. Here we show that by engineering an exceptionally controlled environment using rotationally magic11,12 optical tweezers, we can achieve long-lived entanglement between pairs of molecules using detectable hertz-scale interactions. We prepare two-molecule Bell states with fidelity $$0.92{4}_{-0.016}^{+0.013}$$ , limited by detectable leakage errors. When correcting for these errors, the fidelity is $$0.97{6}_{-0.016}^{+0.014}$$ . We show that the second-scale entanglement lifetimes are limited solely by these errors, providing opportunities for research in quantum-enhanced metrology7,13, ultracold chemistry14 and the use of rotational states in quantum simulation, quantum computation and as quantum memories. The extension of precise quantum control to complex molecular systems will enable their additional degrees of freedom to be exploited across many domains of quantum science15–17. By engineering an exceptionally controlled environment using rotationally magic optical tweezers, long-lived entanglement between pairs of molecules using detectable hertz-scale interactions can be achieved.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"637 8047","pages":"827-832"},"PeriodicalIF":50.5,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41586-024-08365-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Correction: Evolution of immune genes is associated with the Black Death","authors":"Jennifer Klunk, Tauras P. Vilgalys, Christian E. Demeure, Xiaoheng Cheng, Mari Shiratori, Julien Madej, Rémi Beau, Derek Elli, Maria I. Patino, Rebecca Redfern, Sharon N. DeWitte, Julia A. Gamble, Jesper L. Boldsen, Ann Carmichael, Nükhet Varlik, Katherine Eaton, Jean-Christophe Grenier, G. Brian Golding, Alison Devault, Jean-Marie Rouillard, Vania Yotova, Renata Sindeaux, Chun Jimmie Ye, Matin Bikaran, Anne Dumaine, Jessica F. Brinkworth, Dominique Missiakas, Guy A. Rouleau, Matthias Steinrücken, Javier Pizarro-Cerdá, Hendrik N. Poinar, Luis B. Barreiro","doi":"10.1038/s41586-024-08522-6","DOIUrl":"https://doi.org/10.1038/s41586-024-08522-6","url":null,"abstract":"<p>Correction to: <i>Nature</i> https://doi.org/10.1038/s41586-022-05349-x Published online 19 October 2022</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":"5 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142986630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}