IF 64.8 1区综合性期刊

Nature Pub Date : 2024-11-19 DOI: 10.1038/d41586-024-03798-0

引用次数: 0

Killer questions at science job interviews and how to ace them 科学工作面试中的杀手级问题以及如何应对这些问题

IF 64.8 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03761-z

引用次数: 0

Why we need a body to oversee how science is used by governments 为什么我们需要一个机构来监督政府如何利用科学？

IF 64.8 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03758-8

引用次数: 0

First rocks returned from Moon's far side reveal ancient volcanic activity. 从月球远侧发回的首批岩石显示了远古时期的火山活动。

IF 50.5 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03778-4

Davide Castelvecchi

引用次数: 0

Is it really a sin if it’s hardwired in? The neurological basis for ‘bad’ behaviour 如果这是硬性规定，真的是罪过吗？不良 "行为的神经学基础

IF 64.8 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03759-7

引用次数: 0

What a forest’s glow can reveal about the impact of environmental change 森林的光辉可以揭示环境变化的影响

IF 64.8 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03763-x

引用次数: 0

Adipose tissue retains an epigenetic memory of obesity after weight loss. 减肥后，脂肪组织会保留肥胖的表观遗传记忆。

IF 50.5 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/s41586-024-08165-7

Laura C Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn

{"title":"Adipose tissue retains an epigenetic memory of obesity after weight loss.","authors":"Laura C Hinte, Daniel Castellano-Castillo, Adhideb Ghosh, Kate Melrose, Emanuel Gasser, Falko Noé, Lucas Massier, Hua Dong, Wenfei Sun, Anne Hoffmann, Christian Wolfrum, Mikael Rydén, Niklas Mejhert, Matthias Blüher, Ferdinand von Meyenn","doi":"10.1038/s41586-024-08165-7","DOIUrl":"10.1038/s41586-024-08165-7","url":null,"abstract":"Reducing body weight to improve metabolic health and related comorbidities is a primary goal in treating obesity1,2. However, maintaining weight loss is a considerable challenge, especially as the body seems to retain an obesogenic memory that defends against body weight changes3,4. Overcoming this barrier for long-term treatment success is difficult because the molecular mechanisms underpinning this phenomenon remain largely unknown. Here, by using single-nucleus RNA sequencing, we show that both human and mouse adipose tissues retain cellular transcriptional changes after appreciable weight loss. Furthermore, we find persistent obesity-induced alterations in the epigenome of mouse adipocytes that negatively affect their function and response to metabolic stimuli. Mice carrying this obesogenic memory show accelerated rebound weight gain, and the epigenetic memory can explain future transcriptional deregulation in adipocytes in response to further high-fat diet feeding. In summary, our findings indicate the existence of an obesogenic memory, largely on the basis of stable epigenetic changes, in mouse adipocytes and probably other cell types. These changes seem to prime cells for pathological responses in an obesogenic environment, contributing to the problematic 'yo-yo' effect often seen with dieting. Targeting these changes in the future could improve long-term weight management and health outcomes.","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":50.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geological Net Zero and the need for disaggregated accounting for carbon sinks. 零地质净值和碳汇分类核算的必要性。

IF 50.5 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/s41586-024-08326-8

Myles R Allen, David J Frame, Pierre Friedlingstein, Nathan P Gillett, Giacomo Grassi, Jonathan M Gregory, William Hare, Jo House, Chris Huntingford, Stuart Jenkins, Chris D Jones, Reto Knutti, Jason A Lowe, H Damon Matthews, Malte Meinshausen, Nicolai Meinshausen, Glen P Peters, Gian-Kasper Plattner, Sarah Raper, Joeri Rogelj, Peter A Stott, Susan Solomon, Thomas F Stocker, Andrew J Weaver, Kirsten Zickfeld

{"title":"Geological Net Zero and the need for disaggregated accounting for carbon sinks.","authors":"Myles R Allen, David J Frame, Pierre Friedlingstein, Nathan P Gillett, Giacomo Grassi, Jonathan M Gregory, William Hare, Jo House, Chris Huntingford, Stuart Jenkins, Chris D Jones, Reto Knutti, Jason A Lowe, H Damon Matthews, Malte Meinshausen, Nicolai Meinshausen, Glen P Peters, Gian-Kasper Plattner, Sarah Raper, Joeri Rogelj, Peter A Stott, Susan Solomon, Thomas F Stocker, Andrew J Weaver, Kirsten Zickfeld","doi":"10.1038/s41586-024-08326-8","DOIUrl":"10.1038/s41586-024-08326-8","url":null,"abstract":"Achieving net zero global emissions of carbon dioxide (CO2), with declining emissions of other greenhouse gases, is widely expected to halt global warming. CO2 emissions will continue to drive warming until fully balanced by active anthropogenic CO2 removals. For practical reasons, however, many greenhouse gas accounting systems allow some \"passive\" CO2 uptake, such as enhanced vegetation growth due to CO2 fertilisation, to be included as removals in the definition of net anthropogenic emissions. By including passive CO2 uptake, nominal net zero emissions would not halt global warming, undermining the Paris Agreement. Here we discuss measures addressing this problem, to ensure residual fossil fuel use does not cause further global warming: land management categories should be disaggregated in emissions reporting and targets to better separate the role of passive CO2 uptake; where possible, claimed removals should be additional to passive uptake; and targets should acknowledge the need for Geological Net Zero, meaning one tonne of CO2 permanently restored to the solid Earth for every tonne still generated from fossil sources. We also argue that scientific understanding of net zero provides a basis for allocating responsibility for the protection of passive carbon sinks during and after the transition to Geological Net Zero.","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":50.5,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fat cells have a 'memory' of obesity - hinting at why it's hard to keep weight off. 脂肪细胞对肥胖有 "记忆"--这暗示了为什么很难保持体重。

IF 50.5 1区综合性期刊

Nature Pub Date : 2024-11-18 DOI: 10.1038/d41586-024-03614-9

Traci Watson

引用次数: 0

Publisher Correction: Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. 出版商更正：组织间隙是布氏锥虫抗原多样性的贮藏库。

IF 50.5 1区综合性期刊

Nature Pub Date : 2024-11-16 DOI: 10.1038/s41586-024-08389-7

Alexander K Beaver, Zhibek Keneskhanova, Raúl O Cosentino, Brian L Weiss, Erick O Awuoche, Gretchen M Smallenberger, Gracyn Y Buenconsejo, Nathan P Crilly, Jaclyn E Smith, Jill M C Hakim, Bailin Zhang, Bryce Bobb, Filipa Rijo-Ferreira, Luisa M Figueiredo, Serap Aksoy, T Nicolai Siegel, Monica R Mugnier

引用次数: 0

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