NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03251-4
Philip Ball
{"title":"Economics Nobel awarded for work on stabilizing economies in crisis.","authors":"Philip Ball","doi":"10.1038/d41586-026-03251-4","DOIUrl":"https://doi.org/10.1038/d41586-026-03251-4","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03224-7
David Adam
{"title":"Does the decline of book reading mark the end of rational thinking?","authors":"David Adam","doi":"10.1038/d41586-026-03224-7","DOIUrl":"10.1038/d41586-026-03224-7","url":null,"abstract":"Smartphones and artificial intelligence are undermining our ability to follow a complex argument, with grave consequences.","PeriodicalId":18787,"journal":{"name":"Nature","volume":"658 8136","pages":"601-603"},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149177746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03255-0
Flora Graham
{"title":"Daily briefing: Visit a huge climate experiment in the Amazon rainforest.","authors":"Flora Graham","doi":"10.1038/d41586-026-03255-0","DOIUrl":"https://doi.org/10.1038/d41586-026-03255-0","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/s41586-026-11250-8
Stephen Tang, Josephine L Ramirez, Qixiang He, Mario Rodríguez Mestre, Tanner Wiegand, Dennis J Zhang, Megan Wang, George D Lampe, Jing Wang, Yanzhe Ma, Marko Jovanovic, Rafael Pinilla-Redondo, Israel S Fernández, Samuel H Sternberg
{"title":"Antiviral immunity via telomerase-like reverse transcription in bacteria.","authors":"Stephen Tang, Josephine L Ramirez, Qixiang He, Mario Rodríguez Mestre, Tanner Wiegand, Dennis J Zhang, Megan Wang, George D Lampe, Jing Wang, Yanzhe Ma, Marko Jovanovic, Rafael Pinilla-Redondo, Israel S Fernández, Samuel H Sternberg","doi":"10.1038/s41586-026-11250-8","DOIUrl":"https://doi.org/10.1038/s41586-026-11250-8","url":null,"abstract":"<p><p>Defense-associated reverse transcriptases (DRTs) employ diverse and distinctive mechanisms of cDNA synthesis to protect bacteria against viral infection<sup>1</sup>. However, the functions and mechanisms of many DRTs remain unknown<sup>2</sup>. Here we identify a new antiviral defense system, DRT10, that associates with a noncoding RNA (ncRNA) to catalyze processive, protein-primed synthesis of tandem-repeat DNA. Reverse transcription is templated by a defined ncRNA region with a characteristic sequence pattern and template boundary elements, both of which are conserved and essential for DNA repeat addition. Cryo-EM reconstructions reveal an unanticipated 2:1 architecture, wherein two RT monomers bind opposite sides of a pseudo-symmetric ncRNA. Biochemical experiments further demonstrate that each RT monomer reverse transcribes the template encoded on its respective side of the ncRNA, but only one generates the long repetitive product, whose template is defined by the distance between two flanking stem-loop anchors. This mode of iterative, boundary-delimited cDNA synthesis exhibits direct parallels to the mechanism of telomeric repeat addition by eukaryotic telomerase, and phylogenetic analyses of RTs across domains of life place telomerase in a monophyletic clade with the DRT family, suggesting a common origin for their DNA polymerization activities. Together with earlier studies of DRT2, DRT3, and DRT9<sup>3-5</sup>, our findings identify a conserved mechanistic logic underlying RNA-templated DNA repeat addition across diverse DRTs, despite vastly different architectural solutions, and expand the repertoire of reverse transcription-based strategies for antiviral immunity in bacteria.</p>","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/s41586-026-11253-5
Aleksandra E Kamizela, Daniel Leongamornlert, Nicholas Williams, Xin Wang, Kudzai Nyamondo, Kevin Dawson, Michael Spencer Chapman, Jing Guo, Joe Lee, Karim Mane, Kate Milne, Anthony R Green, Timothy Chevassut, Peter J Campbell, Patrick T Ellinor, Brian J P Huntly, E Joanna Baxter, Jyoti Nangalia
{"title":"Author Correction: Timing and trajectory of BCR::ABL1-driven chronic myeloid leukaemia.","authors":"Aleksandra E Kamizela, Daniel Leongamornlert, Nicholas Williams, Xin Wang, Kudzai Nyamondo, Kevin Dawson, Michael Spencer Chapman, Jing Guo, Joe Lee, Karim Mane, Kate Milne, Anthony R Green, Timothy Chevassut, Peter J Campbell, Patrick T Ellinor, Brian J P Huntly, E Joanna Baxter, Jyoti Nangalia","doi":"10.1038/s41586-026-11253-5","DOIUrl":"https://doi.org/10.1038/s41586-026-11253-5","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03207-8
Rachel K Rowe
{"title":"Hidden signals in sleep can predict future health.","authors":"Rachel K Rowe","doi":"10.1038/d41586-026-03207-8","DOIUrl":"https://doi.org/10.1038/d41586-026-03207-8","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03181-1
Chris Simms
{"title":"What does a PhD pay? Data reveal huge gaps across Europe.","authors":"Chris Simms","doi":"10.1038/d41586-026-03181-1","DOIUrl":"https://doi.org/10.1038/d41586-026-03181-1","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149167541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-12DOI: 10.1038/d41586-026-03240-7
Rachel Fieldhouse
{"title":"Award-winning microscopy image disqualified over AI use.","authors":"Rachel Fieldhouse","doi":"10.1038/d41586-026-03240-7","DOIUrl":"https://doi.org/10.1038/d41586-026-03240-7","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-09DOI: 10.1038/d41586-026-03217-6
Andrew Robinson
{"title":"The life of Darwin and the science of clouds: Books in brief","authors":"Andrew Robinson","doi":"10.1038/d41586-026-03217-6","DOIUrl":"https://doi.org/10.1038/d41586-026-03217-6","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":"11 1","pages":""},"PeriodicalIF":64.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NaturePub Date : 2026-10-09DOI: 10.1038/d41586-026-03243-4
Flora Graham
{"title":"Daily briefing: Rogue 'jumping genes' age bigs dogs faster than little ones.","authors":"Flora Graham","doi":"10.1038/d41586-026-03243-4","DOIUrl":"https://doi.org/10.1038/d41586-026-03243-4","url":null,"abstract":"","PeriodicalId":18787,"journal":{"name":"Nature","volume":" ","pages":""},"PeriodicalIF":56.1,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149183274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}