Science Progress最新文献

{"title":"Virome capture sequencing for comprehensive HPV genotyping in cervical samples.","authors":"Thanayod Sasivimolrattana, Sasiprapa Liewchalermwong, Wasun Chantratita, Insee Sensorn, Arkom Chaiwongkot, Parvapan Bhattarakosol","doi":"10.1177/00368504251334515","DOIUrl":"https://doi.org/10.1177/00368504251334515","url":null,"abstract":"<p><p>ObjectiveThis study aims to explore HPV genotyping in the cervical specimen using VirCapSeq by comparing the results with the reverse blot hybridization assay (REBA).MethodsA secondary cross-sectional data of HPV genotypes in 35 cervical specimens was obtained from VirCapSeq and REBA methods. The .FASTQ files were downloaded from the NCBI Sequence Read Archive (SRA) (accession number PRJNA766412) and HPV genotyping was bioinformatically analyzed by mapping the sequences to the PaVE database. HPV genotypes detected by REBA and NGS were compared. All specimens were stratified by histology into cervical intraepithelial neoplasia grades 1 (CIN1) and 2/3 (CIN2/3).ResultsNGS via VirCapSeq detected HPV DNA in 100% of the samples, whereas the REBA (hybridization-based) assay diagnosed HPV DNA in 85.71%. While the limitation of the conventional methods for HPV genotyping is the use of primers or probes, NGS detected a broader range. The results showed that mixed infections were detected in all samples by NGS, with HPV16 and HPV52 being the most abundant genotypes.ConclusionsHPV genome abundance, coverage, and diversity were associated with detection discrepancies between the methods, highlighting the enhanced sensitivity and diagnostic capabilities of NGS. These findings underscore the potential of NGS technologies for comprehensive HPV genotyping, advancing cervical cancer screening, and epidemiological studies. Future research should address cost barriers and expand cohort sizes to validate these findings.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251334515"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new fault diagnosis method for reciprocating piston pump based on feature fusion of CNN and transformer encoder.","authors":"Yuehua Lai, Ran Li, Zhuang Ye, Yonghua He","doi":"10.1177/00368504251330003","DOIUrl":"https://doi.org/10.1177/00368504251330003","url":null,"abstract":"<p><p>Reciprocating piston pump is an important power equipment in coal mine production, so the research on condition monitoring and fault diagnosis of reciprocating piston pump is of great significance. It is challenging to extract fault information from monitoring data due to the complex underground environment and serious noise. The existing methods have the problems of insensitive feature extraction and low diagnostic accuracy. Based on this, a new fault diagnosis method for reciprocating piston pumps based on feature fusion of convolutional neural network (CNN) and transformer encoder is proposed. In this method, a multi-scale CNN encoder and transformer encoder are used to extract local and global features of signals in parallel, and a multi-scale convolution module is used to improve the diversity of local features. At the same time, before using the transformer encoder to extract global features, patch segmentation of monitoring signals is carried out in combination with the phase of the reciprocating piston pump crankshaft to reduce the influence of data randomness on global features and improve the interpretability of global features. In addition, a feature fusion module is constructed to realize the interaction and fusion of local and global features and improve the comprehensive characterization ability of the device state. The proposed method is applied to the fault diagnosis task of reciprocating piston pump. The experimental results show that the proposed method achieves a diagnostic accuracy of 99.145% ± 0.1576%, demonstrating its excellent performance. This accuracy rate is significantly higher than that of other existing methods, indicating that the proposed method can more accurately diagnose the faults of reciprocating piston pumps.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251330003"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of chirp stimuli in Kalman-weighted auditory brainstem response testing.","authors":"Jiayan Yang, Suju Wang, Zhiyuan Zhang, Xinheng Ru, Daofeng Ni, Zhiqiang Gao, Hong Jiang, Wen Sun, Yingying Shang","doi":"10.1177/00368504251337226","DOIUrl":"https://doi.org/10.1177/00368504251337226","url":null,"abstract":"<p><p>ObjectiveThe Vivosonic Integrity auditory brainstem response (ABR) system, featuring the Kalman-weighted averaging algorithm, was designed for awake testing in infants and young children. Despite reducing noise and state dependency, previous research has indicated that testing conditions still significantly affect ABR thresholds. Compared with the click stimulus most commonly used in clinical ABR testing, chirp stimuli compensate for the temporal dispersion occurring in the cochlea and overcome the traveling wave delay caused by the special anatomical structure of the cochlea. They enable more nerve fibers to discharge synchronously, thereby generating a stronger evoked waveform, which in turn enhances the anti-interference capability of ABR testing. The present study aimed to explore the application of chirp stimuli in Kalman-weighted averaging ABR and to optimize solutions for obtaining objective hearing results in nonsedated states.MethodsTwenty-four adults (48 ears) with normal hearing aged 18-34 were enrolled for ABR testing using the Vivosonic Integrity system in three states: lying, sitting, and writing, which simulate the states of young children most commonly encountered during nonsedated ABR testing. Chirp/narrowband-chirp (NB-chirp) ABR thresholds and acquisition durations were recorded and compared with previous results of click ABR (cABR)/tone-burst ABR (tbABR) with Kalman-weighted averaging.Results(1) The thresholds and acquisition time of the chirp/NB-chirp ABR increased significantly generally in the order: lying < sitting < writing. (2) Chirp/NB-chirp ABR showed less variance across states, closer responses to the hearing threshold, and shorter testing durations than cABR/tbABR.ConclusionsChirp/NB-chirp ABR with the Kalman-weighted averaging algorithm demonstrated better noise resistance and shorter testing time than cABR/tbABR. These stimuli together with Kalman-weighted averaging provide advantages for threshold measurement in awake subjects, but it still requires respective normal and correction values for each testing state.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251337226"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12035182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144053725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial inoculants - fostering sustainability in groundnut production.","authors":"Kaviya Sree Krishnan, Anandham Rangasamy, Yuvasri Errakutty Arunan, Balachandar Dananjeyan, Thiyageshwari Subramanium, Vincent Saminathan","doi":"10.1177/00368504251338943","DOIUrl":"https://doi.org/10.1177/00368504251338943","url":null,"abstract":"<p><p>Groundnut (<i>Arachis hypogaea</i> L.) is a vital leguminous oilseed crop, widely cultivated in tropical and subtropical regions due to its high nutritional and economic significance in food, feed, and oil purposes. It is a rich source of protein, oil, vitamins, minerals, and bioactive compounds with anti-inflammatory, anticancer, and anti-aging properties. Globally, groundnut production is approximately 54.2 million tonnes, with India contributing 10.1 million tonnes through rainfed cultivation. However, its productivity is constrained by drought, salinity, soil nutrient deficits, and disease infestations. Conventional farming depends on chemical inputs to enhance yield and productivity but negatively impacts soil health and fertility, reduces microbial diversity, and pollutes agroecosystems, creating an urgent need for sustainable alternatives. Microbe-based bioinoculants comprising nitrogen-fixers, phosphorus solubilizers, potassium solubilizers, sulphur oxidizers, other plant growth-promoting rhizobacteria (PGPR), mycorrhizal fungi, and cyanobacteria offer an alternative approach to enhance the growth and yield of groundnut through various direct and indirect mechanisms, including augmenting nutrient absorption, improving quality parameters, suppressing plant pathogens, stimulating plant defence, and increasing resilience to abiotic stresses. This narrative review examines the diversity, benefits, and growth-promoting mechanisms of rhizospheric, phyllospheric, and endophytic microorganisms associated with groundnut. Additionally, molecular docking of groundnut root exudate metabolites, produced upon microbial inoculation, with stress-responsive proteins highlights the significance of microbial inoculants in mitigating drought and salinity stresses. This review synthesizes recent advances in microbial inoculant applications, highlighting their potential to revolutionize sustainable groundnut cultivation. Therefore, microbial inoculants provide a promising solution ensuring sustainability and assurance of food security amid global difficulties.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251338943"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12059452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of a \"speed-technical\" model for elite female race walkers based on random forest.","authors":"Yibing Wang, Yiqun Pang, Siji Wang, Xiubing Zhang, Yunxiang Pang, Houlin Li, Xiaobing Wang","doi":"10.1177/00368504251337973","DOIUrl":"https://doi.org/10.1177/00368504251337973","url":null,"abstract":"<p><p><b>Objective:</b> The rapid development of race-walking techniques and the growing global competition have heightened the importance of optimizing the relationship between technique and speed. This study aims to investigate the interaction between race-walking speed and technique and to establish the optimal combination of technical factors that contribute to peak performance. <b>Methods:</b> A \"Speed-Technical\" model was developed using random forest algorithms, with the SHAPley (Shap) method applied to evaluate the influence of various technical indicators on race-walking speed. <b>Results:</b> The analysis revealed the following hierarchy of factors impacting speed: Step frequency > Step length > Thigh angle > Flight distance > Upper-forearm angle > Head undulation distance > Landing angle > Rear pedal angle > Backpedal distance > Back swing distance > Arm swing angle > Front support distance > Front swing distance > Flight time. The optimal technical ranges for maximizing race-walking speed were found to be: Step frequency (>230 steps/min), Step length (>1.12 m), Thigh angle (50°-65°), Flight distance (0.26 m), Upper-forearm angle (77°), Head undulation distance (0.6-0.8 m), Landing angle (25°-30°), Rear pedal angle (32°-39°), Backpedal distance (0.37-0.43 m), Back swing distance (0.43-0.47 m), Arm swing angle (57°-62°), Front support distance (0.19-0.25 m), Front swing distance (0.25-0.30 m), and Flight time (<0.042 s). <b>Conclusion:</b> The study identifies the key technical factors that most significantly impact race-walking speed, offering novel insights that complement previous findings while highlighting differences in optimal ranges compared to traditional models. These results enhance our understanding of the intricate relationship between technique and speed, providing valuable implications for training and performance optimization.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251337973"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved YOLOv5 s and transfer learning for floater detection.","authors":"Lei Guo, Yiqing Zhang, Qingqing Tian, Yunlong Ran","doi":"10.1177/00368504251342075","DOIUrl":"https://doi.org/10.1177/00368504251342075","url":null,"abstract":"<p><p>This study aims to address the detection and classification of floating objects on water surfaces, including items such as bottles, plastic bags, aquatic plants, and dead fish, which pose significant threats to water quality and ecosystems. Traditional detection methods rely on manual observation and cleanup, which are inefficient, costly, and risky. To tackle this challenge, this paper proposes a solution based on an improved YOLOv5 s model by collecting floating object image data and constructing and processing the dataset using manual photography and SAGAN data augmentation techniques. We optimized the YOLOv5 s model by integrating the EfficientNetv2 lightweight network, the content-aware reassembly of features lightweight upsampling module, the bidirectional feature pyramid network structure, and by introducing attention modules such as squeeze-and-excitation and efficient multi-scale attention, along with the scylla intersection over union (SIoU) loss function. Additionally, transfer learning techniques were employed to enhance the model's performance in detecting floating objects on water surfaces, and ablation experiments were conducted to validate the effectiveness of each improvement. The results show that the improved YOLOv5 s model exhibits better performance and generalization ability on the test set, with a 5.27 percentage point increase in model accuracy. The model's parameter count, computational load, and weight size are 53.9%, 21.3%, and 54% of the original YOLOv5 s model, respectively, providing an efficient, accurate, and real-time solution for detecting floating objects on water surfaces. The methodology presented in this paper holds significant importance for the monitoring of aquatic ecological environments and the management of floating debris, offering valuable insights for achieving precise and efficient detection and classification of floating objects on water surfaces.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251342075"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12078954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel nonsense mutation in the TCOF1 gene associated with treacher collins syndrome: A case report.","authors":"Santiago Cadena-Ullauri, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Patricia Guevara-Ramírez, Viviana A Ruiz-Pozo, Fernando Agama Cuenca, Ana Karina Zambrano","doi":"10.1177/00368504251338915","DOIUrl":"10.1177/00368504251338915","url":null,"abstract":"<p><p>Treacher Collins Syndrome (TCS) is a congenital disorder characterized by craniofacial malformations. In this case, a novel likely pathogenic nonsense variant, in the <i>TCOF1</i> gene, associated with TCS, was reported. Genetic analysis was performed on an Ecuadorian participant (Subject A) and his mother (Subject B), both of whom exhibited characteristic features of TCS. Next-generation sequencing (NGS) identified a single nucleotide variant (c.4423A > T) in exon 25 of the <i>TCOF1</i> gene, resulting in a premature stop codon (p.(Lys1475Ter)) and a truncated treacle protein. The likely pathogenic variant presented in Subjects A and B could alter critical functions of the protein, contributing to the craniofacial malformations of the subjects. The variant informed in this case report contributes to the knowledge of <i>TCOF1</i> gene variants associated with TCS and highlights the importance of genomic screening for accurate diagnosis and improved clinical management in patients and families.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251338915"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144103268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WIPF1 regulates stemness in small cell lung cancer.","authors":"Hongyong Fu, Mingji Quan, Qianqian Qiu, Fanjie Jin","doi":"10.1177/00368504251345012","DOIUrl":"https://doi.org/10.1177/00368504251345012","url":null,"abstract":"<p><p>ObjectiveSmall cell lung cancer (SCLC) is a highly malignant subtype of lung cancer. Cancer stem cell (CSC)-like cells have been implicated in chemoresistance and recurrence. Although previous studies have demonstrated the significance of WASP-interacting protein (WIPF1) in malignant tumors, its underlying molecular mechanism in SCLC is not well known. Here, we demonstrate that WIPF1 can regulate tumorigenesis and its underlying molecular mechanism in SCLC.MethodsSphere-formation culture effectively enriches CSC-like cells, such as tumor stem cell-like cells. RNA-seq was used to identify differentially expressed genes between enriched CSCs (3D cultures) and differentiated cells. Next, we adopted RNA interference techniques to investigate the effects of WIPF1 on colony and sphere-formation capacity, as well as cisplatin sensitivity in SCLC cells. Furthermore, we performed western blot analysis to analyze protein expression and employed the STRING database to identify potential signaling pathways.ResultsWIPF1 was significantly upregulated in sphere-formed SCLC cells, relative to differentiated ones under adherent growth conditions (2D cultures). The gene was involved in the regulation of colony formation, sphere-formation capacity, and cisplatin sensitivity in SCLC cell line model. Knocking down of WIPF1 significantly suppressed the proliferation of cancer cells via the YAP/TAZ protein.ConclusionsSphere-formation and chemoresistance represent indispensable characteristics of CSC-like cells. Notably, sphere-formation culture is a more effective approach for enriching of CSCs-like cells than traditional adherent culture. Upregulation of WIPF1 in sphere-formed cells, relative to differentiated ones, indicated that it plays an important role in the tumorigenesis of SCLC. Moreover, this process is mediated by the YAP/TAZ pathway, suggesting that it may be a potential therapeutic target for SCLC.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251345012"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicomponent exercise improved cognitive flexibility and muscular fitness in community-dwelling older adults.","authors":"Yi-Ling Chen, Ching-Hsiang Chen, Ruey-Rong Huang, Chien-Hsing Tseng, Hsueh-Chin Chao","doi":"10.1177/00368504251346018","DOIUrl":"https://doi.org/10.1177/00368504251346018","url":null,"abstract":"<p><p>ObjectiveCognitive flexibility is the ability to transition between various tasks flexibly, which declines in aging. The purpose of this quasi-experimental study was to investigate the effect of a 12-week multicomponent exercise intervention on cognitive flexibility and attention, measured by color trail test (CTT)-1, CTT-2, and CTT 2-1 difference, in community-dwelling older adults. The relationship between cognitive flexibility and muscular fitness was also examined.MethodsThe participants were assigned to either the exercise group (<i>n</i> = 41, aged 70.6 ± 5.9 years) or the control group (<i>n</i> = 18, aged 67.9 ± 4.9 years). The exercise group participated in a 90-minute multicomponent exercise session, including endurance, resistance, and stretching training, twice a week for 12 weeks. Participants in the control group maintained their sedentary lifestyle. CTT and muscular fitness, including 30-second arm curl, 30-second chair stand, and 2-minute step tests, were measured before and after the intervention.ResultsA significant group×time interaction effect was found in CTT-2, CTT 2-1 difference, chair stand, and step test. After the intervention, the exercise group showed a significantly better cognitive flexibility, indicated by faster completion time in CTT-2 (before: 140.3 ± 60.1 seconds, after: 127.0 ± 60.6 seconds) and improved CTT 2-1 difference (before: 82.8 ± 49.5 seconds, after: 72.2 ± 49.0 seconds). The exercise group also improved the number of repetitions in chair stand (before: 18.5 ± 5.0, after: 22.8 ± 5.5) and step test (before: 108.9 ± 16.2, after: 126.2 ± 19.0). The cognitive and muscular performance remained unchanged in the control group. Moreover, better performance in the 30-second chair stand test was associated with faster completion time in CTT-1 at baseline (<i>r</i> = -0.296).ConclusionsThe amelioration in cognitive flexibility coincided with improvements in muscular fitness after a 12-week multicomponent exercise intervention in older adults. Better muscular strength was associated with higher cognitive flexibility at the baseline.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251346018"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between intracranial artery stenosis and aneurysm rupture risk: Proximal stenosis as a potential protective factor.","authors":"Yudi Tang, Jian Lv, Peike Chen, Junqiang Feng, Xiaoyan Wang, Dachao Wei, Siming Gui, Jia Jiang, Zhengkun Xu, Yan Zhao, Yuhua Jiang, Youxiang Li, Peng Liu","doi":"10.1177/00368504251346013","DOIUrl":"https://doi.org/10.1177/00368504251346013","url":null,"abstract":"<p><p>ObjectiveParent artery and hemodynamics are related to intracranial aneurysms (IAs) rupture. Although proximal parent artery stenosis (PPAS) can both change parent artery configuration and hemodynamics, correlation between PPAS and IAs rupture has not been clearly clarified in large sample size. This study aims to explore the correlation between PPAS and IAs rupture in a large Chinese cohort.MethodsA retrospective cross-sectional study was conducted. Imaging and clinical data were collected from consecutive patients with IAs diagnosed by CTA between January 2013 and December 2022. Two neuroradiologists independently assessed the characteristics of the IAs. To minimize the effect of confounding variables, propensity score matching (PSM) was applied.ResultsAfter PSM, no significant differences were found between groups for interference factors. However, IAs in the PPAS group had a significantly lower proportion of ruptures compared to the non-PPAS group (p = 0.031). Additionally, unruptured aneurysms had a significantly higher prevalence of PPAS compared to ruptured aneurysms (p = 0.011). There was no significant difference in rupture rates between non-PPAS IAs with other intracranial artery stenosis (IAS) and those without IAS (p = 0.596). And ruptured non-PPAS IAs showed a significantly higher incidence of IAS compared to unruptured non-PPAS IAs (p = 0.010).ConclusionNon-PPAS may be associated with a higher risk of aneurysm rupture. In contrast, PPAS may be associated with unruptured aneurysm.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 2","pages":"368504251346013"},"PeriodicalIF":2.6,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144163876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}