Science Progress最新文献

{"title":"Associations of nutritional intake and body mass index with branch retinal vein occlusion: A cross-sectional study using data from a Korean national survey.","authors":"Bokyung Kim, Eunseob Kim, Yun Tae Kim, Mingui Kong","doi":"10.1177/00368504261441718","DOIUrl":"10.1177/00368504261441718","url":null,"abstract":"<p><p>ObjectiveThis study aimed to evaluate the associations between body mass index (BMI), dietary nutrient intake, and the risk of branch retinal vein occlusion (BRVO) in a nationally representative Korean population, with a focus on sex- and BMI-specific differences.MethodsThis population-based cross-sectional study analyzed data from adults aged ≥40 years who participated in the 7th and 8th Korea National Health and Nutrition Examination Surveys (KNHANES) conducted between 2017 and 2021. BRVO was diagnosed using standardized fundus photography and optical coherence tomography interpreted by certified retinal specialists. BMI was categorized according to Asia-Pacific criteria, and dietary intake of macronutrients and micronutrients was assessed using structured nutrition surveys. Comparisons were performed between participants with and without BRVO, stratified by sex and BMI category. Survey-weighted logistic regression models were applied to account for the complex sampling design and to adjust for age, smoking status, alcohol consumption, hypertension, diabetes mellitus, and BMI.ResultsA total of 15,790 participants (6,629 men and 9,161 women) were included, of whom 96 (43 men and 53 women) were diagnosed with BRVO. Participants with BRVO were significantly older and had a higher prevalence of hypertension (all P < 0.001). Overall, individuals with BRVO showed significantly lower intakes of protein, crude fiber, iron, sodium, and potassium (all P < 0.05). Although overall BRVO prevalence did not differ significantly across BMI categories, sex-stratified analyses revealed an increasing prevalence with higher BMI in women. Associations between dietary nutrient intake and BRVO varied across BMI strata.ConclusionsLower nutrient intake and metabolic risk factors, including hypertension and BMI, may be associated with BRVO risk. The observed sex- and BMI-specific differences highlight the importance of tailored nutritional and metabolic risk assessment. Longitudinal studies are warranted to clarify causal relationships.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261441718"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biomarkers and clinical factors associated with sepsis-induced coagulopathy: A systematic review and meta-analysis.","authors":"Wei You, Xiaoyu Fan, Ping Xu, Cheng Lei, Yanli Zeng","doi":"10.1177/00368504261435291","DOIUrl":"10.1177/00368504261435291","url":null,"abstract":"<p><p>ObjectiveSepsis-induced coagulopathy (SIC) is a life-threatening complication that significantly impacts patient prognosis. This systematic review and meta-analysis aimed to evaluate clinical and biological indicators associated with the development of SIC to facilitate early risk identification.MethodsWe searched nine databases for studies reporting predictive factors for SIC. Data were pooled using random-effects or fixed-effects models as appropriate. Methodological quality was assessed using the Newcastle-Ottawa Scale.ResultsA total of 34 studies involving 37,459 patients were included. Meta-analysis revealed that several markers showed a significant association with SIC. Glycocalyx degradation emerged as a strong predictor (<i>OR</i> = 11.85, 95% CI: 8.59-16.34). Other associated markers included reduced Fibrinogen (<i>OR</i> = 4.35, 95% CI: 2.47-7.69), Albumin (<i>OR</i> = 2.5, 95% CI: 1.82-3.45), Neutrophil Extracellular Traps (<i>OR</i> = 2.4, 95% CI: 1.81-3.19), increased circulating Microparticles (<i>OR</i> = 1.61, 95% CI: 1.33-1.95), elevated Lactate(<i>OR</i> = 1.18, 95% CI: 1.13-1.23) and Thrombomodulin (<i>OR</i> = 1.10, 95% CI: 0.97-1.26), Procalcitonin, APACHE II score and C-reactive protein were also demonstrated predictive value for SIC occurrence.ConclusionOur findings identify multiple biological and clinical predictors associated with SIC. However, these results should be interpreted as statistical associations rather than direct causal links. These markers may assist clinicians in early recognition of high-risk patients, though further prospective trials are needed to confirm their clinical utility.RegistrationThis study was registered on the PROSPERO (CRD420250653820).</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261435291"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ACL injury in female soccer players: Risk, resilience, and prevention in the modern game.","authors":"Riccardo D'Ambrosi, Philipp Baumert, Christian Fink","doi":"10.1177/00368504261428994","DOIUrl":"10.1177/00368504261428994","url":null,"abstract":"<p><p>Anterior cruciate ligament (ACL) injury is one of the most impactful conditions in female soccer, with major consequences for knee function, osteoarthritis risk, and professional longevity. As participation and competitive demands in women's football continue to rise, the disproportionate ACL burden has become a critical clinical and public health concern.This narrative review provides a contemporary synthesis of current evidence on ACL injury in female soccer players, integrating data on epidemiology, injury mechanisms, intrinsic and extrinsic risk factors, surgical outcomes, return to sport (RTS), and prevention strategies. Across multiple cohorts, female players sustain ACL injuries at rates two to nine times higher than males, predominantly through noncontact mechanisms. Video analyses indicate that approximately 90% of injuries occur during cutting, pressing, deceleration, or landing tasks.Key intrinsic risk factors include a reduced hamstring-to-quadriceps strength ratio, quadriceps dominance, generalized joint laxity, hip abductor weakness, and longer playing experience. Biomechanical deficits such as dynamic knee valgus, trunk instability, and suboptimal change of direction mechanics further increase susceptibility. Psychological factors, particularly fear of reinjury, also influence movement patterns and RTS.Although ACL reconstruction generally yields favorable outcomes, reinjury remains a major concern in athletes returning to pivoting sports, with reported RTS rates ranging from 70% to 78%. Neuromuscular-based prevention programs, including FIFA 11+-derived protocols, can reduce ACL incidence by 40-45% when consistently implemented; however, adherence and limited sex-specific tailoring remain significant barriers.ACL injury in female soccer players is a multifactorial and largely preventable condition, requiring integrated, sex-specific prevention and rehabilitation strategies to effectively reduce risk and support long-term athletic health.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261428994"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of airway obstruction severity in relation to air pollutant in asbestos-exposed chronic obstructive pulmonary disease individuals: A cross-sectional study.","authors":"Min Yu, Xinan Lu, Chiyun Chen","doi":"10.1177/00368504261449072","DOIUrl":"https://doi.org/10.1177/00368504261449072","url":null,"abstract":"<p><p>ObjectiveDespite of the tentative role of asbestos in chronic obstructive pulmonary disease (COPD), their lung function variation in relation to air pollution remains unexplored. This cross-sectional study aimed to explore the effects of air pollution on severe airway obstruction (SAO) in asbestos-related COPD.MethodsCOPD subjects were retrospectively recruited, and their asbestos exposure and SAO were verified using the existence of pleural plaque in chest X-ray and the predicted value of forced expiratory volume in 1 second in percentage less than 50%, respectively, followed by examining the association between PM_2.5, PM₁₀, SO₂, NO₂, O₃, and CO and SAO stratified by asbestos exposure using regression model.ResultsSAO percentage was 67.2% (41/61) and 65.2% (15/23) in COPD subjects without and with asbestos exposure, respectively. An increased 3-day average concentration of CO and O₃ correlated with SAO (odds ratio, 95% confidence interval: 0.06, 0.01-0.41 and 0.09, 0.01-0.64, respectively). Moreover, an increased 5-day average CO concentration also correlated with SAO (0.13, 0.02-0.71) prior to hospital admission of COPD subjects irrespective of asbestos exposure, and SAO failed to be associated with asbestos exposure.ConclusionsCertain gaseous pollution at low concentration might generally exhibit a negative association with SAO in COPD subjects, indicating the negligibly negative impact of air pollution on lung function deterioration in asbestos-related COPD.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261449072"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infective endocarditis and precision medicine: A narrative review.","authors":"Julián Orlando Casallas-Barrera, Laura Marcela Castilla Gómez, Paola Andrea Castro Ochoa, Ricardo Buitrago-Bernal","doi":"10.1177/00368504261433083","DOIUrl":"https://doi.org/10.1177/00368504261433083","url":null,"abstract":"<p><p>Infective endocarditis (IE) remains a life-threatening condition with high global morbidity and mortality, demanding more effective strategies for early detection and management. Precision medicine offers a transformative approach, starting with comprehensive risk profiling that combines genetic predisposition, preexisting comorbidities, and lifestyle factors such as intravenous drug use and oral hygiene. This paradigm extends to point-of-care diagnostics and culminates in targeted, patient-specific treatment strategies. To explore its potential in IE, we systematically searched PubMed, Scopus, and Embase, identifying and synthesizing key literature into a narrative review. Our findings highlight precision medicine as a promising framework to enhance timely diagnosis and support individualized therapeutic decision-making in IE.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261433083"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111819/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the naples prognostic score with revascularization strategies in patients with prior CABG and NSTE-ACS: A retrospective single-center observational study.","authors":"Rauf Avcı, Ayşegül Ülgen Kunak, Muhammed Rıdvan Ersoysal","doi":"10.1177/00368504261449039","DOIUrl":"https://doi.org/10.1177/00368504261449039","url":null,"abstract":"<p><p>ObjectivePatients with a prior history of coronary artery bypass grafting (CABG) presenting with non-ST-elevation acute coronary syndrome (NSTE-ACS) represent a high-risk population in whom revascularization decisions are frequently individualized in real-world practice. Objective biomarkers capable of supporting treatment selection in this setting remain limited. The Naples Prognostic Score (NPS), a composite index integrating inflammatory and nutritional parameters, may reflect overall clinical vulnerability.MethodsIn this retrospective, single-center observational cohort study, the association between NPS and treatment strategy selection was evaluated in 367 patients with prior CABG presenting with NSTE-ACS between January 2019 and October 2025. NPS was calculated at admission prior to coronary angiography using total cholesterol, neutrophil-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, and serum albumin levels. Patients were categorized into low (0-2) and high (3-4) NPS groups. Treatment strategies were determined through routine multidisciplinary clinical assessment and were not influenced by study investigators. Multivariable logistic regression and prespecified stratified sensitivity analyses were performed.ResultsRevascularization was selected in 169 patients (46.0%), including 164 percutaneous coronary interventions and 5 redo CABG procedures. Patients undergoing revascularization had significantly lower NPS values. High NPS was independently associated with a lower likelihood of being selected for revascularization (OR 0.28, 95% CI 0.17-0.48; p < 0.001). Procedural success rates following PCI were similar between NPS groups (89.0% overall; p = 0.161). Results remained consistent across stratified sensitivity analyses according to clinical presentation, chronic kidney disease status, and age categories.ConclusionsHigher NPS values were associated with a lower likelihood of revascularization without affecting procedural success. NPS appears to reflect disease burden and clinical vulnerability rather than treatment benefit. It may also capture acute inflammatory status and should be considered a complementary, not decisive, clinical marker.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261449039"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of seed packaging, storage conditions, and durations on seed quality of open-pollinated maize (<i>Zea mays</i> L.) varieties in Ethiopia.","authors":"Kedir Oshone Hussen, Karta Kaske Kalsa","doi":"10.1177/00368504261441381","DOIUrl":"https://doi.org/10.1177/00368504261441381","url":null,"abstract":"<p><p>ObjectiveThis study investigates the combined effects of storage environments and packaging materials on the seed quality of open-pollinated maize (<i>Zea mays</i> <b>L</b>.) (OPM) varieties intended for planting purposes after long-term storage.MethodsMelkassa-2, Melkassa-4, and Melkassa-6Q seeds were stored under cold and ambient storage conditions. Subsequently, the seeds were packed into Polypropylene woven bags and multilayer polyethylene lined hermetic (Super GrainPro (SGPr) and Purdue Improved Crop Storage (PICS)) bags and stored for 24 months. The combined analysis was done using a completely randomized design (CRD) with factorial arrangement replicated three times. The temperature of the refrigerator for cold storage was maintained at 5 ±3 °C with a relative humidity of 42 ±3%. In 2021, the annual mean temperature of ambient conditions ranged from 14.27 to 28.57 °C with relative humidity (RH) between 47% and 75%. In 2022, the annual mean temperature ranged from 13.97 to 29.51 °C with RH between 40.10% and 70.13%. The evaluation was conducted at Melkassa Agricultural Research Center. Seed quality traits were measured every 6 months for 24 months.ResultsThe study found significant interaction (P≤0.05) effects between storage environment, maize variety, and seed packaging material on seed germination after 18 and 24 months of storage. Hermetic bags under cold storage maintained seed quality for up to 24 months, while non-hermetic bag under ambient storage preserved seeds for up to 12 months. Non-hermetic storage bags led to a decline in seed quality after 12 months.ConclusionsHermetic bags (PICS) combined with cold storage can prolong the shelf life of EGS for open-pollinated maize varieties for up to 24 months. However, SGPr and PPW bags stored under the same conditions showed significant deterioration after 12 months. This approach can help improve seed quality and longevity, leading to accessibility for breeding programs, EGS producers, and smallholder farmers.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261441381"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147610742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of circRNAs in N⁶-methyladenosine(m⁶A), cell death and clinical applications in human breast cancer.","authors":"Shuting Chen, Jiahui Mao, Xiufen Zhuang, Yifan Jiang, Yichen Zou, Min Xiang, Yang Shu","doi":"10.1177/00368504261436956","DOIUrl":"https://doi.org/10.1177/00368504261436956","url":null,"abstract":"<p><p>Breast cancer (BC) is widely recognized as the most frequently diagnosed neoplasm among women worldwide. Despite significant advances, improved diagnosis and treatment of breast cancer have failed to translate into earlier detection or markedly better outcomes for patients, due to challenges including late-stage presentation, metastasis, recurrence, metabolic reprogramming, and drug resistance. Identifying reliable predictive indicators for early intervention and diagnostic markers remains a priority in breast cancer research, as this is crucial for improving patient prognosis. Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs) abundant in various tissues and human cells, are established biomarkers for diagnosing and monitoring diseases such as those affecting the nervous, cardiovascular, and immune systems. CircRNAs contribute to tumorigenesis through the regulation of proliferation, metastasis, angiogenesis, and the tumor microenvironment. A growing body of evidence has established circRNAs as key regulators in breast cancer, elucidating their specific roles in driving tumor development and progression. Nevertheless, a more comprehensive understanding of the functional roles and molecular mechanisms of circRNAs in BC is essential and requires further research. This narrative review synthesizes the current knowledge on circRNAs encompassing their biogenesis, characteristics, methylation, tumor cell death, and selectively analyzes the translational potential of circRNAs in BC patients.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261436956"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of precipitated calcium citrate in 24-hour urine samples is clinically useful for ruling out calcium oxalate urolithiasis.","authors":"Chaiyadol Tantasith, Praween Tubsaeng, Kamonchat Boonkam, Natcha Madared, Chanchai Boonla","doi":"10.1177/00368504251363660","DOIUrl":"10.1177/00368504251363660","url":null,"abstract":"<p><p><b>Objective:</b> Combining calcium with citrate clinically prevents the formation of calcium oxalate (CaOx) stones. In this study, we developed a new method for measuring calcium citrate (CalCit) precipitated out of urine samples. <b>Method:</b> CalCit in urine was formed by challenging with excessive calcium and precipitated out by ethanol. The precipitated CalCit (pCalCit) was redissolved and measured by an indicator displacement assay (IDA) using murexide as an indicator. This method is called the murexide-based IDA for measurement of precipitated CalCit (miDA-pCalCit). <b>Results:</b> Urea, creatinine, ammonia, sulfate, carbonate, uric acid, oxalate, albumin, and bilirubin did not interfere with the pCalCit measurement. The limit of detection and limit of quantitation were 80 and 400 μM, respectively. The miDA-pCalCit test was clinically validated in 24-hour urine samples obtained from CaOx stone patients and nonstone forming (NSF) subjects. The urinary pCalCit levels of CaOx stone patients were significantly lower than NSF subjects. Receiver operating characteristic analysis revealed an area under curve of 0.823 (95% confidence interval [CI]: 0.752-0.893) for separating CaOx stone patients from NSF subjects. At the cutoff of 632 µM, the test provided sensitivity, specificity, positive predictive value, negative predictive value, positive likelihood ratio, negative likelihood ratio (LH-), and accuracy of 84.4%, 70.1%, 51.4%, 92.5%, 2.9, 0.2, and 74.3%, respectively. <b>Conclusions:</b> We successfully established the miDA-pCalCit test for measuring pCalCit in 24-hour urine samples. The urinary pCalCit levels in CaOx stone patients decreased significantly compared with NSF individuals. With an LH- of 0.2, the negative test result could be clinically helpful for ruling out CaOx urolithiasis.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504251363660"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular clips for primary closure in classic carotid endarterectomy: A 5-year exploratory retrospective cohort study.","authors":"Kang She, Xiansheng Zhang, Zhengheng Yu, Jie Yin, Gong Cheng","doi":"10.1177/00368504261442730","DOIUrl":"10.1177/00368504261442730","url":null,"abstract":"<p><p>ObjectiveTo evaluate the intraoperative efficiency and long-term outcomes of clip-assisted primary closure versus conventional suturing in classic carotid endarterectomy (CEA).MethodsThis single-center retrospective cohort study included 46 classic CEA procedures in 45 patients treated between 2013 and 2019. Procedures were divided into a clip group (n = 15) and a suture group (n = 31). The primary endpoints were carotid clamping time and intraoperative blood loss. Secondary endpoints included operative time, postoperative drainage volume, perioperative stroke, long-term stroke incidence, and all-cause mortality.ResultsThe clip group had a significantly shorter carotid clamping time than the suture group (12.67 ± 5.74 min vs. 18.26 ± 7.84 min, P = 0.048) and significantly lower intraoperative blood loss (38.00 ± 18.97 mL vs. 56.77 ± 23.01 mL, P = 0.010). No statistically significant between-group differences were observed in total operative time, postoperative drainage volume, perioperative stroke, long-term stroke incidence, or all-cause mortality.ConclusionsIn this exploratory retrospective cohort study, clip-assisted primary closure during classic CEA was associated with shorter carotid clamping time and lower intraoperative blood loss than conventional suturing. No signal of increased perioperative or long-term adverse outcomes was detected; however, the study was not powered to establish equivalence or non-inferiority for rare safety endpoints. These findings support the technical feasibility of clip-assisted primary closure in selected patients, but larger prospective studies are needed to further evaluate its safety and long-term effectiveness.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"109 2","pages":"368504261442730"},"PeriodicalIF":2.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13065293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}