Science Progress最新文献

{"title":"Time-Course physiopathology of <i>Porthidium lansbergii lansbergii</i> Envenomation in Swiss Webster Mice: Insights into Systemic Manifestations.","authors":"Leonel Montealegre-Sánchez, Mikael A Lima, Alejandro Montoya-Gómez, Luis Solano-Redondo, Dayara O Silva, Karuza M Alves Pereira, Mario R Lima Mota, Edilberto Rocha Silveira, Nilce Viana Gramosa Pompeu de Sousa Brasil, Elenilson G Alves Filho, Alexandre Havt, Eliécer Jiménez-Charris","doi":"10.1177/00368504241304205","DOIUrl":"https://doi.org/10.1177/00368504241304205","url":null,"abstract":"<p><strong>Objective: </strong>The expansion of human activities in northern Colombia has increased human-snake encounters, particularly with venomous <i>Porthidium lansbergii lansbergii</i>. Given the limited knowledge of systemic envenomation effects and previous studies focusing only on early murine symptoms, this investigation aimed to describe the time-course physiopathology of <i>P. lansbergii lansbergii</i> envenomation following intramuscular injection <i>in vivo</i>.</p><p><strong>Methods: </strong>Venom was inoculated in the gastrocnemius muscles of Swiss Webster mice, and blood, urine, and tissue samples were taken at different times to evaluate lethality and biochemical markers of renal function and oxidative stress.</p><p><strong>Results: </strong>This study reports the first intramuscular LD₅₀ for <i>P. lansbergii lansbergii</i> venom at 24.83 mg/Kg. Administering 80% of this LD₅₀ induced early signs of renal injury, evidenced by urinary biomarkers over 24 h. The antioxidant activity was found at low levels in kidney tissue throughout the evaluated time post-envenomation. Malondialdehyde activity increased at the earliest point, while proinflammatory activity increased later. Urine metabolomics revealed elevated taurine and allantoin in the envenomed groups.</p><p><strong>Discussion: </strong>Compensatory mechanisms in response to oxidative stress and tissue damage induced by the venom were evident in the envenomed mice over the evaluated time. However, histological analysis revealed evidence of pro-inflammatory processes occurring only at early times. Metabolomic analyses of urine samples identified taurine as a potential early biomarker of elevated oxidative stress and protein and creatinine levels.</p><p><strong>Conclusions: </strong><i>P. lansbergii lansbergii</i> venom induces alterations in murine renal tissue, affecting urinary biomarkers of kidney function within hours post-envenomation. Delayed proinflammatory effects may suggest an antioxidant imbalance in the envenomed mice, with unknown long-term effects. Further research on the role of oxidative stress and inflammation in renal structure and function following envenomation is necessary, emphasizing the need for prompt clinical management.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241304205"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11705321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of moisture in fire hoods and gloves on residual heat accumulation during repeated rest-work cycles at a fire scene.","authors":"Tae-Sun Kim, Ji-Hyun Yang, Tae-Hee Park, Jin-Suk Kwon","doi":"10.1177/00368504251315803","DOIUrl":"10.1177/00368504251315803","url":null,"abstract":"<p><p>Firefighters are exposed to the risk of burns at fire scenes. In 2020, the National Fire Agency of the Republic of Korea surveyed 50,527 firefighters and identified 242 burn-related incidents. The body parts affected by these burns were the hands (28.51%), ears (10.74%), and neck (10.33%), with hands and facial areas accounting for ∼50% of all burns. This trend implies that gloves and hoods do not provide sufficient protection against burns. Firefighters alternate between activity and rest during firefighting operations to enhance mission efficiency. However, the accumulated heat in their hood and gloves from these repeated cycles has not been considered thus far. This study investigated thermal accumulation patterns based on the moisture content of hoods and gloves, reflecting repeated cycles of work and rest for firefighters. Consequently, heat accumulation occurred in a dry state in both the hood and gloves, and the degree of heat storage was higher in the hood. The glove stored heat even when wet because of its multilayer structural characteristics. These results suggest that repeated activities (work-rest) with gloves and hoods under dry/wet conditions can generate residual heat and heat accumulation, causing burns on the hand and face. This study clearly demonstrated the impact of the moisture conditions of gloves and hoods in repetitive situations where they are exposed to relatively low levels of heat radiation and are then subject to rest periods. The results of this study are expected to be valuable in designing new protective gear to prevent burn injuries and developing efficient firefighting tactics.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315803"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11752760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMARCB1/INI-1-Deficient sinonasal carcinoma demonstrates a poor prognosis but favorable clinical outcomes after PD-1/PD-L1 inhibitor therapy: A case series.","authors":"Shuhan Zhao, Hao Du, Zhanjie Zhang, Jinsong Yang, You Zhou, Guixiang Xiao, Hui Ma, Caini Lan, Jinzi Liang, Kunyu Yang, Lu Wen","doi":"10.1177/00368504251315075","DOIUrl":"10.1177/00368504251315075","url":null,"abstract":"<p><p>Despite advances in multimodal cancer therapy, such as combining radical surgery with high-intensity chemoradiotherapy, for SMARCB1/INI-1-deficient sinonasal carcinoma (SDSC), the prognosis of patients remains poor. Immunotherapy is gaining increasing popularity as a novel treatment strategy for patients with SMARCB1/INI-1-deficient tumors. Herein, we report on the management of three patients with SDSC who received PD-1/PD-L1 inhibitor therapy as a part of multimodal therapy based on surgery and chemoradiotherapy. All three patients survived and demonstrated good clinical remission and disease control. To our knowledge, this is the first case series reporting the use of immunotherapy to improve clinical outcomes in neoadjuvant, adjuvant, and late first-line stages of treatment in patients with SDSC. Furthermore, we reviewed the relevant literature and further explored the correlation between SMARCB1/INI-1 deletion and immunotherapy.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251315075"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Virtual screening combined with molecular docking for the !identification of new anti-adipogenic compounds.","authors":"Gilberto Mandujano-Lázaro, María F Torres-Rojas, Esther Ramírez-Moreno, Laurence A Marchat","doi":"10.1177/00368504251320313","DOIUrl":"10.1177/00368504251320313","url":null,"abstract":"<p><p>Obesity is an important risk factor for diabetes, cardiovascular diseases, and cancer, reducing the quality of life and expectancy of millions of people. Consequently, obesity has turned into one of the most health public problems worldwide, which highlights the urgent need for new and safe treatments. Obesity is mainly related to excessive fat accumulation; therefore, proteins participating in white adipose tissue increase and dysfunction are considered pertinent and attractive targets for developing new methods that can help with body weight control. In this context, virtual screening of libraries containing a large number of molecules represents a valuable strategy for the identification of potential anti-adipogenic compounds with reduced costs and time production. Here, we review the scientific literature about the prediction of new ligands of specific proteins through molecular docking and virtual screening of chemical libraries, with the aim of proposing new potential anti-adipogenic molecules. First, we present the targets related to adipogenesis and adipocyte functions that were selected for the following studies: PPARγ, Crif1, SIRT1, ERβ, PC1, FTO, Mss51, and FABP4. Then, we describe the obtention of new ligands according to the characteristics of the virtual screening approach, i.e. a structure-based drug design (SBDD) or a ligand-based drug design (LBDD). Finally, the critical analysis of these computational strategies and the corresponding results points out the necessity of combining computational and <i>in vitro</i> or <i>in vivo</i> assays for the identification of effective new anti-adipogenic molecules for obesity control. It also evidences that translating molecular docking and virtual screening results into successful drug candidates for adipogenesis and obesity control remains a huge challenge.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320313"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11815789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum magnesium levels and the risk of acute kidney injury in ICU patients with acute pancreatitis: A MIMIC-IV cohort study.","authors":"Xuehong Zhou, Shoubing Jin, Dong Wu, Wantong Su","doi":"10.1177/00368504251319648","DOIUrl":"10.1177/00368504251319648","url":null,"abstract":"<p><strong>Objective: </strong>This cohort study investigated the relationship between serum magnesium levels and the incidence of acute kidney injury (AKI) in patients with acute pancreatitis (AP).</p><p><strong>Methods: </strong>We analyzed data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, focusing on adult AP patients (≥18 years old) with ICU stays longer than 24 h. Univariable logistic regression was used to identify key covariates. Both univariate and multivariable logistic regression models were used to evaluate the link between serum magnesium levels and AKI occurrence. A restricted cubic spline (RCS) was used to visualize the associations, and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.</p><p><strong>Results: </strong>During hospitalization, 455 (69.1%) participants experienced AKI. After adjusting for relevant factors, higher serum magnesium concentrations were significantly associated with AKI (OR: 2.247, 95% CI: 1.234-4.091; p = 0.008). Magnesium levels between 1.6-2.6 mg/dL (OR: 1.872, 95% CI: 1.105-1.174, p = 0.020) and ≥2.6 mg/dL (OR: 3.851, 95% CI: 1.08-13.736, p = 0.038) were linked to increased AKI occurrence. The RCS curve indicated a nonlinear relationship, suggesting a potential threshold effect between serum magnesium and AKI risk.</p><p><strong>Conclusions: </strong>Higher serum magnesium levels were found to be associated with AKI in ICU patients with acute pancreatitis. Further studies are needed to explore this relationship.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251319648"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11800255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatigue analysis of railway catenary dropper based on its stress incorporating displacement loading and fluctuating wind load.","authors":"Like Pan, Caizhi Yang, Xinxin Shen, Fan He, Xiaohan Zhu, Yingxin Zhao, Yuan Yuan, Qingyuan Zhao, Qingzhou Meng, Bo Dong, Xiaoli Guo","doi":"10.1177/00368504241311432","DOIUrl":"10.1177/00368504241311432","url":null,"abstract":"<p><p>In this paper, a simple chain suspension catenary model is constructed. The acting force of pantograph is reduced to a displacement loading. The stress and fatigue life of railway catenary dropper incorporating displacement loading and fluctuating wind load are studied. Through writing a MATLAB code, the vibration equation of the dropper is used to calculate its stress under different conditions using a finite difference method, combining with the initial boundary value conditions obtained by the response equations of the contact wire. Based on the dropper stress, its fatigue life can be obtained. The results show that under the 250 km/h train speed, the stress change process of the dropper experiences three stages: immediate rebound, attenuation vibration, and bending compression. Dropper Ⅳ is most likely to break in a span. Compared with dropper Ⅳ, the fatigue life of dropper Ⅰ is 11 times, and those of droppers Ⅱ, Ⅲ, and Ⅴ are about 2.5 times. Compared with no wind, the fatigue lives of droppers Ⅰ-Ⅳ are reduced by approximately three times at a wind speed of 25 m/s. This work provides a powerful means for the study of dropper stress under actual working condition.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241311432"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11840857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting nasal diseases based on microbiota relationship network.","authors":"Yibo Liang, Jie Mao, Tianlei Qiu, Binghua Li, Chenting Zhang, Kai Zhang, Zhe Sun, Guimin Zhang","doi":"10.1177/00368504251320832","DOIUrl":"10.1177/00368504251320832","url":null,"abstract":"<p><strong>Objectives: </strong>Increasing evidence indicates that the local microbiome can be used to predict host disease states. However, constructing models that obtain better results with fewer features is still challenging.</p><p><strong>Methods: </strong>In this study, we established a nasal microbiome database consisting of 132 chronic rhinosinusitis patients, 27 nasal inverted papilloma patients, and 45 control patients. 16S rRNA gene sequencing was used to identify the species and abundance of bacteria in each sample, and a nasal microbiome database was generated after low-abundance bacteria were eliminated. The correlation data network of different groups of bacteria was constructed by calculating the correlation coefficient among bacterial genera, and the correlation parameters of the network were calculated based on graph theory. Through the development and application of a machine learning framework to optimize the screening process, combined with microbiome relationship network parameters based on graph theory, basic bacteria with high contributions to classification prediction were selected for the prediction of nasal diseases.</p><p><strong>Results: </strong>We found that patients with nasal disease have a specific nasal microbiome signature and identified Moraxella, Prevotella, and Rothia as keystone genera that are markers of nasal disease; these markers can be interpreted as key control routes through graph theory analysis of the microbiota. With this strategy, we were able to characterize microbial community changes in nasal disease patients, which could reveal the potential role of the nasal microbiome in nasal disease.</p><p><strong>Conclusion: </strong>This study can provide a reference for the formulation of disease prevention and control policies. Our framework can be applied to other diseases to identify keystone genera that influence disease states and can be used to predict disease states.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251320832"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11833901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deterioration and improvement: The U-shaped impact of industrialization on agricultural carbon productivity in China.","authors":"Gui Zeng, Hana Wang","doi":"10.1177/00368504241302960","DOIUrl":"https://doi.org/10.1177/00368504241302960","url":null,"abstract":"<p><p>Industry and agriculture are two major industries for a country's economic development and also important areas for promoting sustainable development. At present, most countries in the world have started the process of industrialization, and green agriculture is also valued by all countries. So what will be the impact of industrialization on the development of low-carbon agriculture? Studying this problem has a good theoretical and practical significance. To this end, we take the example of China's 2000-2021 provincial samples to study the impact of industrialization on agricultural carbon productivity. The study found that industrialization has a nonlinear effect on agricultural carbon productivity, with a significant U-shaped feature, i.e. first deteriorating and then improving. And there is obvious heterogeneity in this feature. The balance area of grain production and marketing and the main grain selling area are better than the main grain-producing areas, and the eastern and central regions are better than the western region. At the same time, in this process of influence, the level of economic development and urbanization has played a good role mechanism, while the transport infrastructure has played a positive regulatory effect.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241302960"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roles of the CDCA gene family in breast carcinoma.","authors":"Wei Ding, Wei Han, Chun-Tao Shi, Li-Qian Yao, Zhi-Wei Liang, Ming-Hui Zhou, Hao-Nan Wang","doi":"10.1177/00368504241312305","DOIUrl":"10.1177/00368504241312305","url":null,"abstract":"<p><p>Cell division cycle-associated (CDCA) genes are dysregulated in carcinomas. Our study aims to identify similarities and differences of the clinical roles of CDCAs in breast cancer (BRCA) and to explore their potential mechanisms. In GEPIA, compared to normal tissues, expressions of CDCAs were higher in BRCA and sub-types. In addition, CDCAs were significantly positively related to stages and predicted worse survival in BRCA. In CancerSEA, expression levels of most CDCAs were strongly positively related to cell cycle, DNA damage, DNA repair, and proliferation. In TIMER, CDCAs were linked with immune infiltration levels of BRCA, including Dendritic cell, B cell and so on, and were positively related to most of the common markers of immune cells, especially CD38 of B cell and IL12RB2 of Th1. In GeneMANIA, there were complex interactions and co-expression relationships between CDCAs and cell division-associated genes. In addition, CDCA1, CDCA3, CDCA5, CDCA6 and CDCA8 had a high proportion of amplification in BRCA, and CDCA1, CDCA2, CDCA5, CDCA7 and CDCA8 had high levels of body DNA methylation. Among 11 transcription factors possibly combining promoters of all CDCAs, FOXP3 and YY1 were significantly higher in BRCA in comparison to normal tissues, and both had a positive relationship with all CDCAs in GEPIA and IHC. In addition, silencing FOXP3 or YY1 decreased levels of CDCAs in MDA-MB-231. In summary, CDCAs have various similarities in clinical functions, functional states, immune infiltration, and mechanisms, and they may become novel potential biomarkers for BRCA.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504241312305"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automating container damage detection with the YOLO-NAS deep learning model.","authors":"Thanh Nguyen Thi Phuong, Gyu Sung Cho, Indranath Chatterjee","doi":"10.1177/00368504251314084","DOIUrl":"10.1177/00368504251314084","url":null,"abstract":"<p><p>Ensuring the integrity of shipping containers is crucial for maintaining product quality, logistics efficiency, and safety in the global supply chain. Damaged containers can lead to significant economic losses, delays, and safety hazards. Traditionally, container inspections have been manual, which are labor-intensive, time-consuming, and error-prone, especially in busy port environments. This study introduces an automated solution using the YOLO-NAS model, a cutting-edge deep learning architecture known for its adaptability, computational efficiency, and high accuracy in object detection tasks. Our research is among the first to apply YOLO-NAS to container damage detection, addressing the complex conditions of seaports and optimizing for high-speed, high-accuracy performance essential for port logistics. Our method showcases YOLO-NAS's superior efficacy in detecting container damage, achieving a mean average precision (mAP) of 91.2%, a precision rate of 92.4%, and a recall of 84.1%. Comparative analyses indicate that YOLO-NAS consistently outperforms other leading models like YOLOv8 and Roboflow 3.0, which showed lower mAP, precision, and recall values under similar conditions. Additionally, while models such as Fmask-RCNN and MobileNetV2 exhibit high training accuracy, they lack the real-time assessment capabilities critical for port applications, making YOLO-NAS a more suitable choice. The successful integration of YOLO-NAS for automated container damage detection has significant implications for the logistics industry, enhancing port operations with reliable, real-time inspection solutions that can seamlessly integrate into predictive maintenance and monitoring systems. This approach reduces operational costs, improves safety, and lessens the reliance on manual inspections, contributing to the development of \"smart ports\" with higher efficiency and sustainability in container management.</p>","PeriodicalId":56061,"journal":{"name":"Science Progress","volume":"108 1","pages":"368504251314084"},"PeriodicalIF":2.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786269/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}